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<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3BIC4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="Proteomes" id="UP000054399">
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    </dbReference>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="38200" checksum="9CE5E1AD19447702" modified="2025-10-08" version="1">MREPPYISLTTLAPIHEVHHLIFRETDPLHLLTLSKSIFNYLLPKLYHTLPVDSTNVKQILYGVTSPGGYKAQALSYVKRLEIGIDGRGDLLRTALHDLFELSSLPRPLFSRLEHIHFGHSLWEPYDGPSGMFEALLPSYIPPCHISFDLCLFPTEQIWSNRDYNLSRQRRLTNFLLVFFHETSASHITFRVFHPSDCTKSSRPYREVDWDVQGESKISADLHMLREWVVPRLLGRSEEELREELERFFENGMEDRFKFLHDDTIAWDWKKRYVFRTGLNAGTTFGRGASEEIESGKHLNTLSPIYRAQYTVYCGIDFQSALISLYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIJ8</accession>
    <name>A0ABR3BIJ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610904.1">
        <property type="nucleotide sequence ID" value="XM_066761079.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993512"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34175" checksum="A9CB2BC3CB84D7B1" modified="2025-10-08" version="1">MTLTPPLPCSALQPPAATFARLFPVCHIIFDQLVLEDPRQYCTLSKSTYKVAIRLLSRKLTITNNNYQKVLPGLASKSGRERLALIHFEHLTLATTNLELLKALQLETDYPVFTRVSQLEFVEKFPWSRLGHIHHELGRENIEDILARHIPAKVFIINIRNPITQGYGYGPALDRISMLLAAFVRARGSCCSQGLPVVFELCIRCKHNVAGWSERRAKAEIQTPRTDQMDDIVLRKRVRYRLRLLKCMFRYPLHCDVHFLSPPPCRSDPTSIASAASRYMVVGKLVLKCVSDFLSRLVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIT1</accession>
    <name>A0ABR3BIT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611105.1">
        <property type="nucleotide sequence ID" value="XM_066760833.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993259"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14942" checksum="66AE966780D0EE02" modified="2025-10-08" version="1">MSSPTPPPPQQASRPVPSYKAYTGPDPSTIAVQRSKAEAERYWARMSRKADESVLPVRVNKALGFGGWIAGTIACAYMVLFADFGPREHVFSPVRREYQKLKQSFFTLSPEEQRIVGLQQEPSVEDESQRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ63</accession>
    <name>A0ABR3BJ63_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Acidic laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_106016</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611226.1">
        <property type="nucleotide sequence ID" value="XM_066760465.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992871"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045167946" description="Acidic laccase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="29"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="161"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="395"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0241844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="71255" checksum="869E22036920EB20" modified="2025-10-08" version="1">MYSTISLLASTLLLSATAHAAIREHWWNITYTDANPDGLQPRRVIGVNGTWPPPVLTAMQGDVIVVHATNGLGDDAIGTSLHSHGMYFNHSNWYDGATGVNQCPIPNGHTLDYAIDTSTQTGTYWIHGHLDGQNTDGLRSPVVIYPQNGTGRTDNVTWDEEFIVAAADWYHEEYPVLEKRDFLHWTNPTGAEPVPKSAVIYAAYKNGTYFSTNEEICAGEGVSDNLSIPFEAGKSYRIRMINMGTLAMFWAAMEGHEMYIIEMDGVEVDPYPIDALTISVAQRYSVWVRALNQTDKNYAFMFMQDTDMYDAVPDDLVLNNTVQITYNSSAPPAAPWIVDDITTFNDTELTPIVHEDLLGDPDVEIVLHAYFDTYDDGTNRASFNNITYQMPTSTPSMLTELTMGNDAFNPAVYGAMTNAFTYPHMAIVQLTVFNWDAGFHPFHLHGHEFQLVSKSFDVTSNDTTINPPLDETQRNPARRDTVVIPPTGMVVLRWRADNPGAWMFHCHIDWHLSSGLAAVMIEAPEQFQSDSASSVPSQITDQCKWWGKGTEGNVVGKFSTTDFKGQPWGPFPLKMGWTPKAIGALAGCILTAIVGVATIVWYASGELDEEELEEEVKREVERKKAKVPVWKKVLKTNVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ86</accession>
    <name>A0ABR3BJ86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106033</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="8"/>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611243.1">
        <property type="nucleotide sequence ID" value="XM_066760482.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992888"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="10">
        <location>
            <begin position="778"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="906"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="911"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0241861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="982" mass="109425" checksum="BE38C60BC9474EDE" modified="2025-10-08" version="1">MGSSPPPPSFLVPTPRNEQQLSFRGSLDLNDKVSSEGGEGGVSMYVRLFEEMIRTVLDGESYLFTQREIWLLNYILDLPYEPRYLLTRLLLRRPSRVHTYTSLIASYSSEIGEEGIKMGMKTLARRLAVPKDIAGSDPDPLPATPIASSSRPGPLPLSAKAQGKRPANALWANKPWADSPSGLTESQERADPELTAALKESHWASKVGRVNVDSDDEDDGSPVGSKRSESVSTPVSTPTVSRQSSGIPTTPAIEFSLTPESPIPVSFLAEDEKSLSLDDLMTCMSLDQLRKVAKTRKLPVSSLSTRESTLNALRDMAKQQTVLGFVPMKGKGGATTAVQEKGKQTTLPFAPKPKQTSESLLTTQLLSSFGGSAIRLSSSLHSLISRVNLIFSRTPPIAPGAPSLMLPSILVTSNKIRYPDYGPPMRSMIWKDQDELLVWERAVGWEAIVTEALGETWDQARKNPNAVLTPGLTSGTGWVNRKEGAKIVRKIWEATWDVWKEMVDGDKGKEVDVSKEQGGLVGDRFQAGHILTRVVYKGAEALGILHEYDNECMVLRALLAQRRWRRGKRGAWYDRLALVLMNHYNSSPTEKEEKLREATQVCIDGLLDEATHLIYRPALSRRLTRLENKLNLPSDERHISYASLLTCETRELNAVRLPENRGVVRARSWSGSVAREDDSEGTGGKDKLVGKSLWMGKEGEVGVEQWVLEWWEKKGYKGYHSESSILTTLFTLLIWPVLFHPLPGAFETSYQTAPLDLGEDTFASSRRELLEGRLAEMSKTKRALELLREVDNQERPRGTWAVGVNWEYEKEDLEEILECLGGKALSGVCRMLAEEYRHRASGVPDLIVWNPETKDARFVEVKGPGDSLSETQKIWIDVLLSAGVQVEVCRVKAVSPTAAQLQSLEKKRKTSSALNTSPNSTDVKRLKRRSTTSTVSAYVKTDEGEYVKFDEVVELDEEDDGWERRDEMRFESGVERREGRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJI6</accession>
    <name>A0ABR3BJI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611146.1">
        <property type="nucleotide sequence ID" value="XM_066760874.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993300"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="57646" checksum="31F270F905DDC485" modified="2025-10-08" version="1">MGLEENEKTIIGVNLTDVELKNEIRPEHARADLDVAGRFLGEIALRENATELLAPCTDEEAKQVRRKADCIILPLLMLALMMGAVDKNALSTAAVLGLRTDLKLSGTEYSWAGSIIFFGQLASVFPALFMMQRLPAGYVVSGNVLIWGIITLCIVACKDATGLLICRFILGFFESISFPGYSLILTSWYTRREQTVRTAVIFNTMSTIFNGLIAFGCSYASDHIAISAWKLQFLINGALTTTLGVVMCFLIPNSPTSAWWLSERQRVIAVLRLRDERTGMENKVFKKSQLLEAVRDYKTWIVLLFNICLNVPTGGINSFNSIIVKSLGFNVQDTMLLSIPNGALNWMAALFLSFVVLKTKQRVLGAALWTIIPLVATVVLHLVPRSNKAGSLVGLLLMYVFWAPYVVMIGVVNANTAGYTKKTIVYGTAYCGYLIGNLIGPQLFFAREAPNYPSGVTGMLTCYCLAIALLGVYYVNIRRLIRKKKEVLENDSDHAVAHDILEDWHDQTDFENVRFKYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKK6</accession>
    <name>A0ABR3BKK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611109.1">
        <property type="nucleotide sequence ID" value="XM_066760837.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993263"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="2">
        <location>
            <begin position="9"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="231" mass="25399" checksum="C89C65C1AAF59677" modified="2025-10-08" version="1">MAQPGLSYKEIADAIASFLEISLHTILCIRQIYPPTTFTRCRAHGVPVYQSRHPTVRSYISQVIASVGKEINEGRLKRMTVVIKSVLTGLPVERMIFDIGYLSGLDGRKDIGLIGAPNADELGLMLRGFLIKLSSLDGQLLDNNEECTFAIIIETNDDLVPSSNTTEDTGPWVPALAKDTLRPSQKEDAECPEKHEPLLSVKAIETGVIDMRLLVQECVAKTGVEQLRPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL66</accession>
    <name>A0ABR3BL66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611903.1">
        <property type="nucleotide sequence ID" value="XM_066759957.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992357"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075:SF0">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075">
        <property type="entry name" value="PUTATIVE ATP-ASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="652"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="727"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1044"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1125"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="666"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="760"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1154"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1174"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1208"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1267"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0243536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1353" mass="147084" checksum="BEC50CD4CEB19DE4" modified="2025-10-08" version="1">MSSKSQQPPTGLSKSAAKKRSKKAAKQSQNPQPQSSPQTSSQIPASVPPLPPASVPDPLDPAFFNFPGPGSYPIDVQYDDTAYYGQVDVPLSQGNFPGSYSIDYNLSLQNGSQIAGLSAPFNITHDDLISAANELYKRMADPEFGSDDAYWSSLPPHIRQFIRDAVPFTGSISQSTPGTTSSQRTMYQMAQQIVQAASQGMGLGHGMSANLMPGINANARPFPSPQQTIGEEFGFHRHPDTREEEYDDEEEIEEDHGHPAANGDAPKKKNKKKKKKGANAAAAVPTSVEPPAPLPPLPPPSTLSKIPRAPAPVPQPQPPGHQPQPLSQQPPSLNPPPPPTPAPAPTPTPPSSRAAGKQPMGTNPPVNPPARSARAAGKAPASAAPPHNAHAGHSHNHPPAAKPPPKGKSPATAPPAKIWTQSSAEDRENIRVFWLGLSEAERRDLLRIEKDAVLKKMKEQHRHSCGCAVCGRKKVNIEMELDQLYEQYYDELRSYAAEQRIAANGLRPPPNGAGPFPGSVEVDANGTVTQYDHRAPELHDHDPDDLDGEESEEYDDDDDYADDDELDDDDIGTDEADVGDEIDEPPPPPVTHRQQPRRPPVKTSSRSEGGDDFLSFGSNLATIKGGILTIADDMLKNDGTKFLEMMEQLAIRRSVREEQNLRDMQEETDEEEEEEDDDESRDEPMTEKERAEEGKRMFQIFAARMFEQRVLQAYRERVAKQREEQLLRELEEEEDSKRAKEEKKAKEAQKKKDKKKAQKQKAEEERLAREAALEEEKRQAKLRKEEAERERIRRQEEERVRREAVKRAAQEEAQRQVLERKRRQQEEKEREEEAARKKREREEKAKKEREAREKELKEKEKEKEKKERETKAAKEKAEKERIARETFEKVERDRMAKEAKEKAEKNRQEKLEAARMEKLRKEEATKKEREAVEQAKIIAAQQAQRERAAKAEKNTVDKAAAERVSAARVAPVTATAPALATLGLKSPSKGSTPQSVPPVPQLSPAKGAARPIASATPVRPMQKTPTAYYPQPVPPAGVASFPRMPLAQNFGPPGLRPTYSTGSPAFSPPHANGSSISPNPPSRGFTDPSPPGFDHSLRTAPIGVGFPPVKPSGRIPSVADDAFSPTVPVSRSLSSAGEIGSLISGSATPDDYRPTPPAPIAPPNLGPIGRPSFSDGQTSGLNALRSSSPPSDRVLGSAALGADDEIVQPQQRRPTTSWDMPTAAPGSGRWSASPSIWGSGDPTPASGWGAPGGMPTVGERPGPPPGLSLSPGAGASVLGQRQPSFGGIGSPFASVGAVGSVIGGGMGVTVGSGLVQGHVGGGGYSQGLFSPQQQQQQQLQLQLQLQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLE5</accession>
    <name>A0ABR3BLE5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611608.1">
        <property type="nucleotide sequence ID" value="XM_066760304.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992710"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0242226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="294" mass="32974" checksum="B83F4E5B4A3BB5F3" modified="2025-10-08" version="1">MSTPTITLNDGVKIPKIGFGLGTTHYAKDCVDHLVSALKTGYNYIDCAQMYSNSKSVKDALQKWGGKREDLFILQKCGSSGDGESEKNPKVILKGLLQEMGVDYVDLYLLHSPLLFAPKYTINEAWAIMEEIKSEGLAKSIGVSNFREEDLLELQKTWKVVPSVNQIEFHPYNFHANNMIRLQDFCHSNKITIQCYGPLTPLTKAPGGPVDSVVKRIAQAKGYEDSQILLNWAAQKSEGVVVTTSANEHRQKLQLEAITQKGELTQDEVNEISEAGKKKFFRAFMQQVWDKARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLV9</accession>
    <name>A0ABR3BLV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612146.1">
        <property type="nucleotide sequence ID" value="XM_066759499.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991896"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="305" mass="33065" checksum="FE507E257A8A0001" modified="2025-10-08" version="1">MSKINVTFDDFDPLLVYSDYTQWSTPNPQNNPTWYNASESETGVPWHEATIHYTTIQGASFAFNFTASSAWIYGAVGPSSSATSYTITLDGTSSSHTAENTTSSDNTLGQGRTLLWSAQGLDEGKLHEVELRNEGSGVGVDLVVLEVDVGENTNNSTLDNTSPEISYSGTWDMNNGSFHGGSSSYTQGAGNEFSFNFTGSALYIYGDQVNDHGLYSIFFNTSTIPYATYNGRSGCAVGGVEKSCEKLGTLKVFKLISILIISNTLLHQLIPLSLLIQRAPTVFAPHPLQAITLLEPLYECCVVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLY0</accession>
    <name>A0ABR3BLY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612169.1">
        <property type="nucleotide sequence ID" value="XM_066759522.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991919"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37521" checksum="F9C0811068DF5218" modified="2025-10-08" version="1">MSSAEEDQFNNLPKFDASKFQPPAWAKTTNFQWDDKNGESSKATAPSAGREEGQNILDLGDDESDDSGDDVFEDAHSTVDPEEAMFTTSELKELLSRATKHKATGNSHYTSKPPRYDDAIVSYKLAIDHLPTFPSDLTDPEQDSKNDDECKAKVKEPVPSGLQEVSEEEAVAIEEAEKAKEGKSPEELEREEVEDEIKECTKACWGNLAACYIATKDDENAVKACTEALKIDPHYTKGLHRRATANERLGTLAALTSAQQDYTLLKTLLPPSSPLLPSIRRSLITLPPKIKSEEKKQYDEMMSKLKDLGNSLLGNFGLSTDNFKFEQQPGGGYSMNFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM17</accession>
    <name>A0ABR3BM17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612207.1">
        <property type="nucleotide sequence ID" value="XM_066759560.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991958"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="279"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="575"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0243840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="661" mass="73440" checksum="E594E5B589F8E0C4" modified="2025-10-08" version="1">MAPSKVKARAAMFEKGVPGTIPCQSTPKSPPADPAPTVPTPPSAADRTERFSDVPLTDPAPSAPEIPETLEASGDPVATPPGKEHGSLFAAISPTPPNTDTSTALHAPAPTASPNASPSGGWKSTMSHLLTRSASSTPEDSRAPSPLARASASTPPPPQSTLSPAHSTALLLHRVDSVPTRDRRLSKDLSVFERGREGFEKVRSEMDSAAMEMRRERESRRTETDIRPVDAPAIDTPDTITETPEDEEVDWTFWGSVVQGYEQVALTHPKELSKAIQQGIPPVIRGAVWQLMSSSKSVDLEEAYKALLKLSSPHEKAIMKDLNRTFPNHKYFKEGGGVGQEGLFMVVKAYSLYDQEVGYTQGLAFIVAALLLNMPDEEAFCVLVRLMDSYNLRSHYTAEMQGLQLRLFQFDRLVEEILPLLHTHFVRKGVKSSMYASQWFMTLFSYRFPLSLVYRVLDIVFAEGIEAVFRFSLALLKKSEEKLVQLDFEQILHFLQADLFEVYRAPPPPPPVENSAGEAAAGDGKEDGQDVDEEWMANEFVRDAFKIRITPLMLDAYASEWEERCRDQNRHAIELDQLRNVNRNLSSQVKQLEASLAAINQEHVELVRQLVMSKIEKEEMENELVRYKMLYAELAHAQQDALSVHSRLSSSSTTDTSKLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM46</accession>
    <name>A0ABR3BM46_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612061.1">
        <property type="nucleotide sequence ID" value="XM_066760115.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992519"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="304" mass="33726" checksum="61D867BA076468B7" modified="2025-10-08" version="1">MRFRTGISNVGLLHKIIRSLAALARSCVIKLSEEQIYFIVPGSESATGVQVWSQVKVSTLFEDYRIESNSKNEIWVEVNLDSLVKVLRSADNSVGGISENMRSSAALSQAEVTLKLNKKQNQPIWAFDIKGYTASRKSMVITHEINVKILSSRRQQDLKEPLCPRPDIHVVLPNLQELRNIVSRLAPVADDVEVSANHEGTMELAVRSSKVNLTTTWKELPIPVTNLEEESEEAEEPPPPGQMMSTTVTIKALLKFLTSYVISSEAIMCICEGYCVIAYVYIGPIDNAEGVLTFYVPGKATDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BME6</accession>
    <name>A0ABR3BME6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612334.1">
        <property type="nucleotide sequence ID" value="XM_066759687.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992086"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="179"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="330" mass="37855" checksum="0C3BB9D589FDBC9D" modified="2025-10-08" version="1">MATDTKGIHNNADENGNFNRQVSSFRNAIQPGGQFPPEKGRYHLYVALGCPWAHRSLIVRQLKGLEDFIGVSVVHPHLHEGGWHFTTPEAAANPAPVSQHSDDSFPGATQDHLFGYSHLSKIYYKANSDYNARFTVPVVWDKVEGTIVNNESSEVIRFFNSAFNELLPEGKAKNLDLYPEELRKEIDELNEWVYHDINNGVYKTGFATTQEAYEKAVIPLGKALDRVNERLSDGREFLVGGRLTEADIRLYTTVVRYDPVYHSHFKCNIGSIRHDYPHVNRWLKNLYWNYPAFKDTTNFDHIKELYWYSQVNLNPTRIVPLGPKHNVEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMF7</accession>
    <name>A0ABR3BMF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">KN homeodomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105398</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TALE/M-ATYP homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611799.1">
        <property type="nucleotide sequence ID" value="XM_066759853.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992253"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KN homeodomain" evidence="6">
        <location>
            <begin position="163"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="406" mass="45175" checksum="9DC85241FAE7891F" modified="2025-10-08" version="1">MLSTCDTSSQSIRKSLQDDLVDFQETFTKVLGKREIDGHERVARKGSNLLTAVKWSSSRHLLDENTVSLAYAVAHNVKVIGSSALQLEQGREDAVGEAMLRIESLLLDQGRRRKCRQRDYEPQPKRCCRGSSSESYNTWPESNLHISAKPSESAPDHTIVRLWFLNNLAYPYPTAQQKDSLAKYAGMQRGKVDSDLTNYRRRAGWTDIMNMWCGGDRNAMKKLMEKVERGKEQRTEILDAVQECKDYLTMKENNRVGDWVKEITQNSDSKYRFGGIILPNVSVASPYSTNRFSTARSFSGSSALSSMSSCSEVSEASAIIPIPSKKRYTRVESISPFKRTRKQTAEVSGSCEPRSIADLQPMPPSPGAAEENTANDSIVPATCLVNASPLSLSSPGETRTKPRPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN60</accession>
    <name>A0ABR3BN60_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_105176</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612280.1">
        <property type="nucleotide sequence ID" value="XM_066759633.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992032"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0243913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="564" mass="63205" checksum="0D85E37328CC81A7" modified="2025-10-08" version="1">MRVRQMFWDERQHLPLSPHPSHLHFLPATISPGADCPFPSPVFKYIGSRRSYSYLAKPLLPIYEKLWYTLPFLVTFLHVFISPYTKVEETPALHAVHDILAHGISSNALQHYDHIVYPGPVARSMIPNLLLAAFTYPLSLVTGVRQGLPLQVLIRLVQTVFFSAGLAHLSSSISLYYRSKLTSRLFLILSTTQFHIPYYAGRTLPNFMALPFALFGISLIIRPSKHSSKPRLGLTIISLTGTIARMEIAPIALALALTLIWQRRLSVFQALSGGVYGGIIGIAMTSVIDVKFLSPNSYACDWWPELSSALFNIMHGKSKDWGVMPWWYYLSALSKLCLASIPLALLGCCISLRRNELDREMLKVLIGPVTGLVVTLSMVAHKEWRFVVYAVPLINILAARGACFLWSRQSTLLSVPVKLQLCFTKAIVLSLCFGNIGATILFASMTTGRPLSMHRSWLSASALHSGVTLFTLPEDEDLVELGLKIFRPESAYERCTYPFGNSPKELWDEGYMWVVNDEWEEFESAGEEGAWGWKVVKLVAGYGTIGKDGLKMVTRLAIMERKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNC4</accession>
    <name>A0ABR3BNC4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTF2H2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612649.1">
        <property type="nucleotide sequence ID" value="XM_066759162.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991553"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0245565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="461" mass="50040" checksum="7B543CE68598AF9C" modified="2025-10-08" version="1">MPLDLNYAPGSEDEEEDNIDDEEFPGPSSRRHGRGAAGKRKGKNKDAGRQAWEGEYQKSWDIVQEDESGSLESAVETLLARGRRKRALMSDTPVRRSIIRHLFIIIDLSESMLDKDYRPTRFEVILGYLRTYVVEWFDQNPLGQIGVIVMRDRLSEVVIPMGGNPEDIVRALSDKRKLEPSGEPSLQNGLVMAKGGMAHLPSTSSLETLVIFSAISTADPDGPITIHNVLDTLVTGRIRTSILSLSGEIKICKQIAERTGGKFGVALDQDHLKDLLWETIPPPATTITPVTANVRSALAAGGRGPNQTGGRAPAGDLMVMGFPIRLPLGGETMCACHGLLRKGGYLCPRCGSKLCDVPTDCEVCGLMVVSSPHLARSFWFLFPVANYGPLAIEDVVGSSETCFGCDCEFSDTSAINAGVAQVEDGVSPAGRYRCAKCKHDFCADCDLYIHDTLHTCPGCSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNG1</accession>
    <name>A0ABR3BNG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612174.1">
        <property type="nucleotide sequence ID" value="XM_066759527.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991925"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23563">
        <property type="entry name" value="TRIP13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="242"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0243807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="575" mass="64181" checksum="6DD2927E2D9DBC6E" modified="2025-10-08" version="1">MSNIIEFGPPPPRSSSSKARNFGSPSSGFSKTLSSEKSFENINDNHEVESHIYEDENVMEEDMMGEESMLVDTDHEEESDEDEEREVIHVEVRQKPFSHLREQPIMQIVTQFIEEDLARIELGCELSGWNEVKILKDHVERIWVEEGVAGVASVQVSEVDIQVHVYKTSLDNEVEEFSADLDDDDSEEKVSAASVRSLPSAELDGIWDTLVYSDDIKARLLNYIYSTILFSESDIDFNVIAWNRVILLHGPPGTGKTSLCRALAQKMSIRLSQKYRHGKIIEINSHSLFSKWFSESGKLVQKLFQTVTEMVEDESGFVVVMIDEVESLTAARAGAMKGNEPSDSLRVVNALLTQLDKLRTRKNVLVMTTSNLVDAIDEAFISRVDLLESVPLPPPRAIYSILSGCLKECITKKLIKRCRILDWKAAEEAQRERKFAGKVATAEKEKDAREVRERGVAASLADLAIRCHAIELSGRTLRKLPVIAHARYLSSSSSSTSSMGEYRSCKVERWVEAMSKVVDVEQEKKHGLASGGNNTRGGEAANAPRHGICCPSVSNGHAHMEKNEIGMMVGTKVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNI7</accession>
    <name>A0ABR3BNI7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104759</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612709.1">
        <property type="nucleotide sequence ID" value="XM_066759222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991615"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0245625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="147" mass="16948" checksum="3EF0507FBABF5131" modified="2025-10-08" version="1">MRKQWRKDHPFGFYARPTKAADGTLNIMSWEVGIPGKAGTDWEGGIYVVKMNFPDEFPTKPPKCKFDPPLFHPNVYPSGTICLSILDEEKSWKPSITVKQICLGIQDLLEHANVNDPAQVEAYHMFKNDRTSYDKRVRQQAIERRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNL4</accession>
    <name>A0ABR3BNL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612741.1">
        <property type="nucleotide sequence ID" value="XM_066759254.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991647"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0245657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34140" checksum="11DBFA80073B40DD" modified="2025-10-08" version="1">MSATVPTLAAAEEPVIDPALMDGDEAVVDQAVTLSAENESDNSSNGQGPSTLQAAITTSGSVSQENTPILDSPAAEALVDVAGPSLVAEASDNAVAGPSTLVHAASANAVPPSSVSVQASSSTQPDAETILIAPSPPHGPWLSREEAEEAIRTYALANNFDVTITHSDVYRHVITMACVKGGKYRCTRGPTHDEVRQRGKRTGKTGCNWRVTIRDENYKPHRYNEEKEKWDYVPMSDLVNIHNHPPILPKDNPKVRHKTITPQVKELIYKEVNKGTPTRKVLEKIQKEFPDCLANMVDVKNLIGRRKKELPTMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNS7</accession>
    <name>A0ABR3BNS7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612807.1">
        <property type="nucleotide sequence ID" value="XM_066759320.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991714"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0245723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33231" checksum="907193F0E31E957C" modified="2025-10-08" version="1">MPYLTKDQKKLWKEDGYLVLPSFFTDEETKDMLDEAKRLCDEFDIEGHPMTTFKTAADDAHVGDEYFLNSGDKIRYFLEPSSVSPATATTPAKLLVPPAQSINKIGHALAVLNPVFRKYTLETPKVADLAKELGEQESPRVLQSMIICKQPRIGGVVPCHNDSTFLYTDPPSAIGAWIALEECTSQNGCLSFLPGSHRLSRTSTRFVRAPNGGTTFVDVPGVEPNTENWDEMEGWKGAPCPPGTLVLIHGSVMHKSPPNPSDKSRLIYTFHMIEGGNGVEYDERNWLQPTKEMPFPALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNX3</accession>
    <name>A0ABR3BNX3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611673.1">
        <property type="nucleotide sequence ID" value="XM_066760369.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992775"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0242291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="108" mass="12456" checksum="A3B5D9C60AB95D3F" modified="2025-10-08" version="1">MGILIRRPDLELRSELKDGLLAPLHRALRPQLTPILQWELVFVLSERVIDGVLVERDNINVNDSAVLGRKKNNAPVFHINMILDSNHDVWRINLKNNSHKYFQAMPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPC6</accession>
    <name>A0ABR3BPC6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612628.1">
        <property type="nucleotide sequence ID" value="XM_066759141.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991532"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="478" mass="52192" checksum="44AE1AF4EBE5818C" modified="2025-10-08" version="1">MADHAAAPVPLHLPAILQNPTNRAARQVEAHNAQQREKAAARRERDSRSNWAPEYNGKGKRVIRRLDNAAFASNPHIVRPTKADYTPPVPLQARPLRPSFPAGTIPRSTPVPPALIPDRDPFSPDSRQGSFSTSLKGTRAMLRKRGKRAEGLVTKADTEIRNWLGGEWGDLNAQKDGQWRVIDQRLVDYASDISGAGSISSTGRRLPTHRGLDALPDLLIENGQIPAILEISRSPAHLSWYLAESFDRLVVHLVSRYYELASWSQDLPTASGQILRVTHVVVPSIAQPNRHPIPGHSLATPETSEVSGQSSSESSYHSLSEGESSGLSEFARSESDIDNDSDTATEMGDAEVGGYSIEEGDTTVMPIPEMSDLSLSENENELTRTFSATSSRYASSEGGSDFGALGDSLTIPRISGHESEDSMAGGWVDMDDESDFGDIPGFSRVKMDAMYNRINPGVRVSARGWESKPTFFEYLYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPD2</accession>
    <name>A0ABR3BPD2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611838.1">
        <property type="nucleotide sequence ID" value="XM_066759892.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992292"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="733"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="792" mass="82659" checksum="C4517438F78CC818" modified="2025-10-08" version="1">MHESPLAHILRRSRLKALASAAGHPLHLDSRANAATEVTSESDAVMDKRFYASLNEYSPQQLSSIQAAESSSAAAAASKSAAAQAASTTARQAAQAAKSSTTESRATSTVAKATSSAHTTSSTSLRATSSTTSSAKSSAASSIIKSVTASSSESSSAVKSSSTSTASRSTVHSTSTHSSSTSTTHITSTVHTSSAVRELTSTIEPSTTSHSSSAIISSSSISSTAAALSNSTNSSSSLSTGAVIGIVFAVVIGIVAVGSFGGWLYRKYITRSYKTNTNTPWSKIDDDITPFDSEKPHDDIYFGPPASVIASSRDLARARSTMSPREYTMFGGASNHAGVGAGRTMGFAAEYPTGLSPPPEAATYGIDLHGRPYTPQAGRTPMLHTYESNYGHQAESYSPYSYQPYSASPTDNMRQFVGPSAYHSPEQQYHTDYVEMPMPSPMPLGGLAHASDEDLKDLDEFADDPQMAGLAYTYEDSPTAGTGSIQGGEEPLTAVVSSTPSKYDPPAQVTRTDDHMAPNFAATDFSAPTQSPLSPLDPTANGSSSSSNGLLPLPLPHFEPLSPFSSSFDSNRRTTEVQPLAMYEDEHRNASESENMQKRLYGEVARTAGIDEPKTPFVEMLPPSNSASPEPMPQSSTNLLNESTNSTSSSFSAPGPALPRLPDLSLQPPRPYQHGQPLSPLTEVPTPMTSSNGGEGAVPNPFDNPSLTVPTSAASRAPAPPYSPYEHYGSYDSMGSPAPSSAGVIRRTSGDGHVAGGLVSPAFPPPSPGGNVPGSVTDSPRMWSRDDAYGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPG2</accession>
    <name>A0ABR3BPG2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613039.1">
        <property type="nucleotide sequence ID" value="XM_066758591.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990969"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="362" mass="40329" checksum="5B60DBB092414C43" modified="2025-10-08" version="1">MSSVWTSESQIHDLGRRASSISTFTIRQAVRRDTIKTRAIEFSFPKKEVEMPKEDQRQSKLTARSVSNFKDETSYIRLPTKFGLRRSTKLKNSADQLAEVLHIDTSVPISSQPSHPSPTPSTTTTLVQSSLYQNNSLPSTPTLRNPPLGKNRRQLHRQCAILDGEPLCPSKPSDFHSSGDISPNATSSCQSIQFARMNPFQDESSIPEDHGDSLGLSPTTTYQDSSPVPLSSILKLFWDLSNGRQLESEEVEDALMRFVASERRSIEDKGDNWDEGARCRVEWLIEQVAVLLNDPIYSPAMSNVLASLSFPEVSPHLQVPSIPFILAKRAMAPRSFSHSHISSGLHHPALHGSHNSQSWPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPK7</accession>
    <name>A0ABR3BPK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome assembly chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612718.1">
        <property type="nucleotide sequence ID" value="XM_066759231.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991624"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20725" checksum="11F389FDC4FC7A68" modified="2025-10-08" version="1">MSSLLEESYSAPPVSITGSQSPPPPIQSYQLRQSVCEVETELLIQTFDDRILVIVTQNGKVGCLTQAFLPQQIPLPPPTIALQSNGHPSNLHILSILPPPPPQASLTPLLGSPPQQTLHELYVSQIATLVWWALQTSGHARRHVVVGLALKQNGNGARNEDSSEEEALVESERERYAGIMDMVSQWPGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPS5</accession>
    <name>A0ABR3BPS5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613159.1">
        <property type="nucleotide sequence ID" value="XM_066758711.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991089"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="17876" checksum="1A1763DEC0FAF2CE" modified="2025-10-08" version="1">MSADKETIAATAETTSVEASGPAATVVKEAEVGEKRKAEEEAPEGDAEKKVKTDEAADKKGKGKSTEEPEPEGEGEAAAEADLEEDDLDNLIVTGKRNRKKVDYSNAEAWKAADLDPDAAEDEEDEEDEDVDAPESPDDDEEFNEEDAAAAAPEEDDEDEDEDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPU0</accession>
    <name>A0ABR3BPU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613154.1">
        <property type="nucleotide sequence ID" value="XM_066758706.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991084"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="29373" checksum="123E04C8BC05EDF0" modified="2025-10-08" version="1">MTETFLSGFHSLPLDIQQTVYDLVCQTPTLGLIQACRTLYNTHVHHLYQNAVLDRKNVAKFFYPILATSEDDMMPVDWDDPPERWPRMERQQVFQLDRSDPPPVCMASFRPTARKLLLFNDISSITFMDEETVYQTERAALLYYKMSAYVSLNAIASCGGYVQEVLFLRADHIVFGPDVAKYMVYRPSNWEEKVRNLSYAFRGPTRVRLEIPEDIMEQVEEAEMIMNKTLIYLGCVELEQRAKSTVGESGREQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ73</accession>
    <name>A0ABR3BQ73_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_104014</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0246982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612943.1">
        <property type="nucleotide sequence ID" value="XM_066758495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990870"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="347"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0246982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="661" mass="73161" checksum="B77529C8B0B6CCA3" modified="2025-10-08" version="1">MSTTRTHGSTTDSSSTTNSASSVSESSATNTTSAVSSSSSNSTTSSTHGSSRPSNSTTSSNSTSSNSNHGSSSSSGGSNRESAVRSNDPYPQVKWMWTAICGVVLLLALWYLLSLYRQRKRQNSKPGTKEAGNRRKPSKWDAVRIGARNSFIARGFPKWLYAPETVADALWTAVYFMVTIIITLYDGPWSMGQVNMSNAFGTIAYAQTPLIFFFAMKNNPISLLTGIPYQNLNYLHRASSRAMLVWSWLHTGLAIAQVKQRKQWSDAYIIWGWVAVGVFTIMWFSSFAIIRRKLHQLFFAIHIVMAVLYLVACYLHWATLGFWLYSCFVIWGFDRTVRLGRTIYYNRIWSQGRGVCKIEILDDSCLRITAVRPGFKWAAGQHAFLISPRLSKWGIAEAHPFTMANVPNDAEEVIILARVYQGYTKQLTDSLSANKDKLIRCYLDGPYGSPHSLGSYDTITLVAGGTGIAPWTAHLAGLLASQKTTRTSYIHIVWLIREATSVCWIAPFIEQTTEKLRNRSDITVKFSFHVTRGQIPAQTEKHTLTSDESASQASTPAIEEISALTHDAESFPDVTLTKTIKPAVVLSHAASQIVEWHQGRAIFAQIFKEDAQTCPEAMAVGVCGPFPLMESVRKSVRQASTIGSVLKGQVPIDYIEETLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ93</accession>
    <name>A0ABR3BQ93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613304.1">
        <property type="nucleotide sequence ID" value="XM_066758856.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991235"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF9">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046577462" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="46"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="144"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="255"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="797" mass="84763" checksum="FEBABAED85B54C19" modified="2025-10-08" version="1">MFSQLLVLGLAVMASVDAHPRLGRPSKYPRRSVIEKRATPATTVSGWSYIGCYKDNGDDRTLSGSKEITSTMTPSACVAYCSGLGYSYAGLEYYDECYCGNSIDSTKLDVDTRCQFACKGDSSQACGGVTRLGVYYKGGSTSTSATYVGCYKDNGDNRTLSGSKKISNTMTPSVCTSYCSGLGYAYAGLEYYDECYCGNSLDSSKATDNSQCQYACTGDSSQKCGGVTRLGVYSLGSPTTTTTTSPASSTTPTSAVTYVGCYKDNGDNRTLNGSKKISSSMTASVCNSYCSGLGYIYAGTEYYNECYCGNTLDSSKAADNSQCQYACAGDNSQKCGGVTRLGVYQLGTSVTATLTTSKASSTPASTSVSANAAVTSAVGVAAVPKASSIKALYAHHMVGNTYSYTQSIWGNDISLASAAGIDGFALNYGRDTWQPARIADAYAAAKAQGSFKLFLSLDVSSLSCSSASDAATHVASIATYANHSAQAMYNSKVLVSTFSGESCTFGQGSVSAGWTYFHSLLTAKGISIYFVPSIFSDTSTYSSDSWMDGEFNWNGGWPTGNAALDTSSDTSYMSALGSKGYMAAVSPCFFTYYSPSSYNKDWIYRSDDWLLARRMEQIISMRNSFDMAEIISWNDYGESHYIGPIRADQPNSQGWTAGMPHTAWLNLVAYYAPAFKTGSYPSASDQMILWTRPHPKAATPTAPTCARPSNWNNTDDNLYVWVALKAAATVTITSGSNSGSWYLQAGVNKVGIASAAGTITGKIVRDSTTVKSYDSNGSFSYTLTPTDYNYNYFVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ95</accession>
    <name>A0ABR3BQ95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613326.1">
        <property type="nucleotide sequence ID" value="XM_066758878.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991257"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="334" mass="36595" checksum="056E8F47FC0BF874" modified="2025-10-08" version="1">MPSDPPPPYQPADASSKSNLQTTAPQGATQSASAGGNAMQRSPTNMSGISDTSTEGTDIDLNDELRDMDDEQRDLPPGWVRCFDPKQQHHFYVDEATKRSTWVHPYDDPEYLRTLPKDHPAHPDSKEARAVRKYSEDEELSKRKRKEIKSVKGDSKAKGTVGTSTEKEGNDDERNWFQRKKDKLIGTKEEREKAKAEKKRLKEEQKKRIQEQEEAYRKRRKELIDKQLNDPMIRSRYAANPYMYSAPAGPFMRNGLYSSPYGFGYGGGYGRRGYYGGLGGMGMGMPLMMGGGAGLLGGMLLADSLDGGYGGGYGGGDMGGGDMGGGDMGGGGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQD3</accession>
    <name>A0ABR3BQD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613355.1">
        <property type="nucleotide sequence ID" value="XM_066758907.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991286"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046741068" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="376"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="483"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="593"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="700"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="807"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="908"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="1007"/>
            <end position="1099"/>
        </location>
    </feature>
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        <location>
            <begin position="1114"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="1216"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="1320"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="1590"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1503"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1503"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1516"/>
            <end position="1536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1731" mass="181092" checksum="578DB095D2517CC3" modified="2025-10-08" version="1">MLKCLLYVVVVFVSSLLSRAQDDAWHLDDTYTLVNEELDPIISPNQQSSHMHKIIGGSKMAAYYNFDDYSAAKCSSLRIQADKSNYWMPQLYFIDNSTNQFVPIYAKIRFYYFLARSSNAEPVISFPKGLRMIAGNPFNKAPTNIASFTCQINEGFTDSLEADNFNFNRDCPYGMKTELFFPPCWDGYNLYKADGSHMAYPSQNVRDGRCPWTHPIRLPAIQLEYTWRTSYYNPGTVLNGRLAWANGDTTGYGIHGDFVNGWDLSVLDAALKDPSCVGINMSIPMDDCPTLYAHFDDAAASTCVPERGVLTETFGNTDLVPIDRLPGCNPLWSEGDKPTCDPPIPGLDASGFTGTDGPYVAAVEDQKNFVWPTEPGWTNIACLHDVSSLSGGTSYADQLITVESCTSSCLKSGYNFAATGQVGTYWTCVCGTSISSDAYVEPGMCTTACPGNSNEACGGSYRFNIWYAPNGTTGNLGTSRNDGSEYLGCYNDPTTVSDGLLGKATYNFQSSSMTTEVCIEACAQAGTKWAATLSARNCYCGNEFYYGTGTFMPDSYCTVACTGNSSEICGDYYKSSVYNITGVQVANASDSHLAGYQGCYQDTSGHLALTNNSWTSTSLTPLTCINGCSELGYSYAGVEGGNTCYCGSHVSSTVTVLPASQCQTACTGNSSDSCGGTQAMDLYTMAAATDTPATIKASHSAGYLGCFKDAGSNMAFNNYYTYHITSMTVETCKAACVELGYLYAGVTDGFQCRCGDNYPQTTQMVSNLYCTQACYGNASETCGAGGYLEGYDLSDMTVAPVMSGTSMGSYVGCYDNSNRGLTNYSYVDGAMTVEACRTTCSEFGYSLAGVYSASYCGCGDDWTGATQKYPSSACQYYACKGNSSEWCGGASQLAMYNASDVAVTYDKPSGWLSCWTDSSTSRSLTGYFYSANPMSAHACRTACNQQGYTYAATEAGSQCLCGNTLGGEKAPTSSCKTACSGNANETCGGPNYMDLYNATGAVADNGIAGYVGCFTDDSSLSTASYVSDYLDVDICNRWCFARGAAYAGVRVSSGSNMQCKCGPSSPSLVTTLSACATPCTANSGQPCGSTTAVGVYQLSQTSVTSGEFPISSNSSGYVGCYHEGSARMLPSYSFSMSTMSNPLCISNCKALGYALAGTEYAQQCWCANTLDATSGGYKVQESDCSTTCSGGVGICGAGSTLSVWSTVNASSDSVAIEGYKGCYSVGTFLSSSPLTYSGDYMTTELCRRTCRSAGYAVAGLTNANTCACGDSANYGAQAAPATCNAPCKGNTTETCGATYSKALTIFDTVGAGAQVPSGFAANYVGCISDGSPRKLSAYSFKNGGMTNDMAYKICSAAGYPAYGTENGNEGYCGSSRLSVALLPDSYCSTACAGIATTQCGGGGRLSYFYVDTTLASRNSTSSTTTASSTSAVANSTSSSPVNTTVQATSSAFINSTTTLSAHETSNTATATASSSSASADINSTDSLTSTASISNFTSAMASQTDANNTSPETMVSASSTSAGSSGGSSITSSTTSSLSSSFTVTATATSTPTSSEASSSSFYSANSSTASASTSVITSTSTSAAAVQTSSVNLGCYSGSSSSFSNAKMTSHGDLTASMCQIWCNANYYSYAGLTNGTTCGCSNELADLTSTSDDLCGSVCSGDASQACGGDGSVYSVYTAVAASQQRKRFEVDQPAAHGQTDNGKKMVFHGRRFLCPFPFPIFMTAQEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQD5</accession>
    <name>A0ABR3BQD5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613018.1">
        <property type="nucleotide sequence ID" value="XM_066758570.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990947"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="397" mass="42547" checksum="B1E4E91823DBC138" modified="2025-10-08" version="1">MDEDFEDLLRDEDKPEYEASWSTNNRPTKTPPSENEIRLCRRVLELEKERNSLAAELSALKARFPTHSNPTVPVADPSSSSSASQPDLPIEIPAPLLPLLGVLRTHIAELTRDNYALRYTFMGQALSRQASITQTATPVFSPTLSLPPQENNIDVEMAATTGDSRPSTGGHAPPSGSSAGQTGVGAGGLDLERVVERVKQLVRENEELGEMLLQLGQRGDEEEWKKSLDDSKAIIESLDSDLSHHLSVVESTRSELKAYKSRFGPLPHNAPDRTTASASSTTRAPPAFAGRGSLQDRISRGPGGDRGGFNGKELRAGPISAGGSDNSVSGQTTVQNQGPMRGGLHQGFPRIAGTRRPLNGIGNANGGNGPFQGHVRGGSIGQGQGAKPDERDFKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQJ0</accession>
    <name>A0ABR3BQJ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613418.1">
        <property type="nucleotide sequence ID" value="XM_066758970.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991352"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="59"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="494" mass="53111" checksum="21A7276A0DD84A24" modified="2025-10-08" version="1">MNMYSFSTWQNFVDFKMSTLSEDDKIGYLPEQDIDSTLHTAPLAELETPKKRKWIQTLSVLIAGVALFSDGYNIQITGYTNTVMAKLYSTALDSTMKTRLSNSILIGDIFGMVLFGLCADRLGRRWGIVGCTFFLVLGVTLATAAHGKSEIGMLWMIVIGRGVAGLGAGGEYAVCTTSAVEAADETHALRKKRGLLVASSTNTAIIAGFVASAIIFLIVLAAYGGEPHVGVWRICFGIGIISPKFPYWLAFKRYWKPLLGCSLVWFLYDAVVYPFNLLAPTIAAGFSSNQSLLASNGWGALVNAFALPGAFFGGFIIDRVGPRQTYALGLVMVAMFGFVIGGAMEPLRNNGTGAFAAFVVLFGLFQCFLSVGPGNCNFIISSESFPTPVRGHALGLAAAIGKAGAAVGTQVFPLIEARFATTLKGQQAIFLVGSGICVVGAIIVMTLVPNRRAQLEDEDVEFRKYLEENGWDTSDMGTLGRIVPEEVVEHDEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQL0</accession>
    <name>A0ABR3BQL0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612525.1">
        <property type="nucleotide sequence ID" value="XM_066759038.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991423"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0245441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31754" checksum="191CBD9BDA935E69" modified="2025-10-08" version="1">MPTSLELFIEMGRLALAGQTVMVTGGSGGIGGAISRLFKKAGCNVIVLGSSQEKLDSFVKSLPAQGGEAWGYSCDLRDRKQIDAVVSKITEERSPIDILINNAGFAIAANAPFWEQDLDNVASVMDVNLSGLMTITHTVLKYSMMQRKPHPTGTILNISSITGHQAPVREFFEASYHTSKAGVEGFTNVLRHELVGTNIRVLLNRPGTTKTEFHARRHGYDKDKTDATYFGSCPLAADDIAVSCLYQCLQPERISVVLLETLGTAQRSLYSVDQEYESRNGQSECREWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQR8</accession>
    <name>A0ABR3BQR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104284</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613210.1">
        <property type="nucleotide sequence ID" value="XM_066758762.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991140"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="64"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="8">
        <location>
            <begin position="170"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="218" mass="24066" checksum="4F7DF3D3502F7FD7" modified="2025-10-08" version="1">MYGDLALQLVNSSHRTTLSSTPQLPLPKYALPLILSICLETRQLGASIASIAESHGQLSLTQDRGLVCNLTVQHLAARRNKRCLLAYLATRVGGIKERWWDAGGGLAYLLSPAASASVNPEADAPDLRSALSPQELDFLRGYNNLMLDYKSDFLDVLDLTAGIEKPPGELMVDVRVVKDAGEVFLDSGERVDFRKGQRFRLERAQVERLIIQGYLEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR39</accession>
    <name>A0ABR3BR39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613288.1">
        <property type="nucleotide sequence ID" value="XM_066758840.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991219"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046734668" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="346"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="408" mass="42322" checksum="01BD7F7B5F5E8449" modified="2025-10-08" version="1">MLLSSIVPSLLLAVSLLSKGTSARAVSNFTLGPNQRRATASTSGSTLKCTTVSGIWLGFNYNFGCLCENDVESFCNDHGISSSWQAVISSQVNSKGSSYFYPNHAQPICDGSGGYTCGSLSRSSNGQCSSTTCDLQKISSNGGCCPRGQTYKDGKCCGAVGCKSSSSQCTPALSCPTYTSNGICCPSGTSGWTGYTTVCCPKGQIENGSTGKCITNCQSGYEYNSSKGKCEPICDTSNGYVYQQASTGKDICCKSGMKACQTVCCPVNQPEVGGTGVCCPSGSQVTNGKCTTPTGKSTNHRRVARQFQEALTASSFYGLAANAKGALCPFGLAACPIGDFASSGQYECLDPLADLQSCGGCESMGTGKDCTVIPGARWMGCNQGVCEVYSCNNGWKRNLNGTGCERLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR60</accession>
    <name>A0ABR3BR60_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613640.1">
        <property type="nucleotide sequence ID" value="XM_066758238.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990613"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045048023" evidence="1">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="195" mass="20447" checksum="40BAD39995E7033C" modified="2025-10-08" version="1">MRFTSMFVAALPFIGSVFAAPLVEKALTPTTSDLTKKDVDVLSVITELQTRVSAAGSIGPHSVEADVTACLNVVIDAFNWCGNELGIDLSVGVHAGVSLFGRDVAIARDADKQQVAQALSNVIQTVNVNIVQPIPAYIARKPSCSKLLDQIDVSLTLILKGVDSLVVGVLILVNSLLKDVGIILTSLLGGLLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRA8</accession>
    <name>A0ABR3BRA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphatidylinositol glycan, class S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103805</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613688.1">
        <property type="nucleotide sequence ID" value="XM_066758286.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990661"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="637"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="641"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0247727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="74039" checksum="E66C729CB9E7AAF8" modified="2025-10-08" version="1">MSTDTPHPAPGPITKTPAEITASINPSPRRRLAIILSFPLLILLAVPFWWCTTSIERLPLPETRISALEGANYTAPRAHILFTADSSAFPTPPPGRRQFDTKDILRSLGKEVTKGVDGIFAKQKASERDVRQWDLVYEGDKEAIGTTLRVHIRTWEYANSSFPLEPYVQLPETGLMTTGIPAGTLVIPVHPDQVGDRNLKLHYKIALINSILSVFPPRPPEIPLRALKYTPNITLSFVLLNEDATQGDYVHSWDIEGTIKDHFLPHLEALRPIFNFTIESQILYHAPLSFEPSYSEIPGGERDKALDATVGVINSMPDHSQQVSMEAAVKVMEDERGNKAWMIDREQMTIFVNSEKWSLDSGSTNNPVLRFLLYVPSTRHRPMRLAVPDSAQAFLLPQFGGVVILNPPFASFQSHSYHLSRIALAPAFHIFTQHLYSLLALPSLPYTPNKLHVPPPPSPFHRPSSLMQPLSPWQVHQVLLARLEENFQEGKKTLKGIVRLVRKIGEMKVGEGVRDTVLGAVIRLEKVQQSANLTALQAFILARDAVELANKAFFDPSMMGLLYFPDEHKFAVYTPLFAPIAVPLIIGLLRELLSRRKRGKAVEYTEKSQNDHAMLDEIQEGAVHGTATSQVDINEKEKTMESSGGSLSDNSPLQTIRSRVIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRN8</accession>
    <name>A0ABR3BRN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613817.1">
        <property type="nucleotide sequence ID" value="XM_066758415.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990790"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="70"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="388" mass="44161" checksum="F185B0577359EBB0" modified="2025-10-08" version="1">MRPLRPEEEQWVFSKHALENTPSRSHGVSLKEELERRKSTIMQMRSLLARVIYVRDHPDPKLKPTSTPYRNVILLAATFVHRFYMRRSLEDFKESLMAATLLWMASKLEENQLKVRHLVNVCLDKYEQSKPLHWRIQWRPMENGQDPSDGYRFWEKRIVVGEQLALEALCFDLFVEQPWVIIRRAIDGLDAQITKLEEAEEKERANTDGVNGAQGKRRGPKITEELIMSLAWPISSEASLSPLSILYPSPIIAFAFLAIIISLIEQTPLSRGISAASEIADKFELDILFTVDGPEGEDLKTVKGCLESFTEYVKMGLIDRNLVRYLTPEPRSVEEIKPFKRSFVLASNESSNASAKVVENSETHSSAEAGESQAKTENSSQLTPSESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS95</accession>
    <name>A0ABR3BS95_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614016.1">
        <property type="nucleotide sequence ID" value="XM_066757632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989987"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0249829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="162" mass="18167" checksum="DFC31D4BEC242930" modified="2025-10-08" version="1">MSLPVRTVGKRLSQSSIIPIPITRSGNNKPKSLQKTKRTFKPNLTHVDWPVTVLGGPVTIDRTKEQSLPKLEGILMQVKKIRDVEKAGGIEGLLLSRRSKDLTPYGAALRAQLFESLHEIRREMEGREELSRLETEEERLRLEAGSPLASTEASQESVSEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSP5</accession>
    <name>A0ABR3BSP5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614165.1">
        <property type="nucleotide sequence ID" value="XM_066757781.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990137"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0249978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="271" mass="30680" checksum="874BAFA22F81E496" modified="2025-10-08" version="1">MEDLSTGSESDYADSWISWFLSSKGNEYFCEVDEDYILDRFNLTGLNAEVVQEYSRALSLITDNLNEDDLDEDTRESIETSARFLYGLIHARFIVTTRGLAKMLEKYRKADFGRCPRVYCYSQPLLPVGLSDIPYQKAVKLYCPRCEDIYSPKSNRHGSIDGSYFGTTFPHMLFMVYPQMIPGKGQPVGSSVADVNRSLLSAGQSREGGVGVSTSAMALKAEMFEPKIFGFKVNESAKLARWRTARRDAQISRLESQEQEQEQEKEKKSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSR7</accession>
    <name>A0ABR3BSR7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613038.1">
        <property type="nucleotide sequence ID" value="XM_066758590.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990968"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF62">
        <property type="entry name" value="AT07585P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="491" mass="53896" checksum="65C35675B6D822D3" modified="2025-10-08" version="1">MTTLSDRIAQSSISLYESLPKHGKPTVRDNGVPEWTILSVISLVVRQSSTFDSDHSDVVVPVSLGTGVKVLPHQKLPPLGDAVHDCHGEVVARRGFIRWLILQAVLLDQKENGQIGQGAHALYVERGENGKLKLKDGVDVWLYVSALPCGDASTLYTAMHQPPEEASQWTELPVPQDNAGSSSTSLFTSYHPLRGRNTYSTVSTLRTKPGRSDSPPTTSMSCSDKIATWACVGLQGGLLADLYEKVKLEGLVIGGAEQPPGWIDDKNVWEDKMKAEADRALYGRVESIKSILPKEYPLHKPQFHFTSTSFPHSKPSISSTYPTAPEPQPSPLSLSFLPWLFVSSNKPGKAPKPSEREIISNGTLLGFPWKAPGTTPVRPRGRSRLCKIETLLAYEALPDTRRSEDPKTYWDYKHRPMSAYQTAKGLLRGIPKKVPGTGVWQQLGDVWSTCAPEEMTQDQQAPPFKGWLISGKDYESFTSAGGLLRGADDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSX5</accession>
    <name>A0ABR3BSX5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_103360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614242.1">
        <property type="nucleotide sequence ID" value="XM_066757858.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990216"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF390">
        <property type="entry name" value="PROTEIN KINASE C, BRAIN ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="125"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="725"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="906"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="997"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1037"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="915"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1041"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1092" mass="121129" checksum="DC926E1C6647D083" modified="2025-10-08" version="1">MTTAVYHTTGPTLFASTFQSAAEHSSSHNNADPYPLSSLQQSVTVPKMTLVNHAFVDAQSEATAHLPEEACPIEEASNDIKNPSSIHRAEETYRTQNPPLTPKHQASTLEASMKSNRYMTKLQDFELIRVLGKGCAGRVLLVKHSQHDTIHAMKAISKRSVFTHDELKHTMTEVSILRRIAVQEPHNRFVSKLHCSFTDQENFYFVMEFYPGGDLATQMEIYGILGDHRTRFYASDITQGLEDLHRHGIIVRDLKPENILLNAKGHAVLADFGLSKKFAYRGDPKPVRVVTYPGQEELPVWAGKGAGSYRSQSGGGGKLVVDKAHSFVGTSEYLSPEVVKRGDYSYAVDWWALGCIVFEGVVGRVPFRKGDEDPPVVLWNKILYGSWDDCFRDPKLARYTPDQTTYEFIDALLQKDPMRRITEPYVKQHEYFSMIDWSTVQRGEYQDPHGLHIHPTAEYNTRYFPKLCLQEHPSVDMSTHDLRDYEVSNGRRTPMNDNALYKLELARYRKELDAFNWSRDWETVSVDQRESEMGSEVGSLFIEEPVVEQRAEARGEVDRLIEGAADYEEDTFNRNLIPATSEGLSVPVDCPDPSESRSLHVPPTISPENTPVAPTLSLPSTTTEFDAATFSSAATFGLPAPATEGLVNSILSPQPKANHEDRGNEVKTPFMELALKELESLGIGIKIATTNNTPMVKDAEVKSEEVTDAQVKQLDDLSTDMEFANGIQDGSNGMDNTDKSLSPSRALSSHAPSNEELIPLIPAPVLTSFIPPIPAQPGSILNPLPSQAVANPHPLPTTVHDNLDLPTDLPLSGLSVSDVISVPSLRAGHASPRLVRCHLCRNSEISIPLARLSVELHGTITRLEDEEWEELATNKEGIPTAPNGSPGTPYFFRSFTGLRHKPSTLVSSSLRRHYGPGSDISSHGSSASPTKSNRRDLKEWKLFEGRKSIENTKRALKGLKAFPPLKSLTREWGKDRAGVARPVLSLRSLPSSVPRCSNVRVGNEGSSFDAPGRQAQITRPDNARRQTELGWIDRHLKRSKPSSAPASQLRGISSSYKSHSDEQRVAVSVTEEQGISTPRLELEEPEPIVWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTB3</accession>
    <name>A0ABR3BTB3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614377.1">
        <property type="nucleotide sequence ID" value="XM_066757993.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990354"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF30">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="373" mass="40797" checksum="9E55964D3B041882" modified="2025-10-08" version="1">MAKYDAVILGSGVLGLSIANELIWKGLKVAVVGKDLPEDLDSTGFASPWAGANWRSVAVNEAERRRDQYTFEQFARLAKEVPHLCERRAYYYFWTGEDAWKEPWYKDLVFGYRVLKPEEVHAPFKYGVTYEAYTLNTPLYLLHLASTLRSARVPIIRARLSSLDEAYSLPQLGPVDLVINATGLGARSLLGVEDPTVFPAKGQTVLVRAPVKECYGRVDPLPQPSQKAYIIPRPGPDGHVILGGCYLPNDWSTNVNPQVAEEILKQCHTLCPRLDGKGGKGTWKDIEVIAHNTGLRPVREAGLRCELEERVIGGKMKAGLATKGGKAGSGRKVSVVHAYGIGPAGYQASLGIAKEVGELVEACVKKSSNKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTI8</accession>
    <name>A0ABR3BTI8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614456.1">
        <property type="nucleotide sequence ID" value="XM_066756987.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989299"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="181"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="274" mass="30443" checksum="A29780F46275B2E1" modified="2025-10-08" version="1">MSFNDLERGQAEPLLRGGAPDQDATFTALKDSVSIQIFKIQSNVQGIQRLVDKLGGNADGDNLRTSLHNLTEATRDMVKHSTLDVKKLAAYPAGGELAIRKPIQTKLSKEFANAITAFQRVQKLSAEKQRLYVENQKRKVDRLVEESEEAHDEPRGSVELEQVQTQQQVQHVSAQELEFQETLIAEREAEIREIESGIHELNDIFRDLGTMVVEQGGLIDNIESNVISVARDSSSAAEELTTAHEYQRKAGKRMVCLFIILAIVAAVILLAILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTL0</accession>
    <name>A0ABR3BTL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614472.1">
        <property type="nucleotide sequence ID" value="XM_066757003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989315"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="138" mass="15116" checksum="C6C39DBAE029DF9A" modified="2025-10-08" version="1">MSVIRLRSLQALRAQRITPAVRIMSRGAASKHDNDPNVLSREKARNLSGTQDTSAPHKEHAPGWNEHLATDAEANVKADQATPDGPPGKDLQSKTIGHVERHHNTSDEPEHHHPRPGPNPTPSEEDVKADRGEASLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTN4</accession>
    <name>A0ABR3BTN4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614501.1">
        <property type="nucleotide sequence ID" value="XM_066757032.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989344"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="863" mass="93214" checksum="01779F033968AC05" modified="2025-10-08" version="1">MACEATAVSTLYFTSTTYISTIIITSTPVVTKPSPSTSLWTTLSCTTSTSRQRDSGLQNLPVSASATGRSTIQSSQLASEGDLVYTTSRTTKPDVTSKMVKKAGTEVEDILIESGQAENSSSGVWGVLASSTRQEPGQLSFLYSEEAKVSDLQVGTKASTTLTSTSLSTKQTTRTPFSLSTSATSDTITIRECNHGRNIRERSPSTYRLALISSLPNVRRQWWSHSSDEDDNGNDDDDDGNDTSDDESCNIITSSITLFYDPITSWSTLYLTSSIASEVVMPTQTIWADCQPGSTDGSTATSRNLSQPTAQAGQEVSQQVTWTGTSEYKGSSMTTEGDSTWVASFSGSLSSWPITTARAEHMSSSIETFSSFSLSITVNTSQKSSKTVTRTSITPTPISMTATSTIVPSYITLSPNTQAAAAADNATSSSAISSTPSSASSHHSKAVSVGATIGGVFGLFALLALFLFVVRWWKKRQRIQRTNELRSSWFYGGDVREPEMGIRSEKDQSEYSFSNSGPQSRFSAPSLLSRQSLAVPTFFGRPISHMRQGSGRFPPILSFKHVPNIFSRREGPNKQQDNRTWAEKYKNPPQSSLGGESLKRKISRPRALMMDTSTDPTGGQVGWGDGGPYPRVGPSLPVAVQQAPSRIGLHEATPLTWGSSYAATPLLHPPSQSGSLGWQSEKSQPELGVVAPSQRQHMKTTRSEGESMHTGEGAVDAAASSFPMPPLTLPASHGLLHDPYASSHLPEIPSISFSPNFSHRNLHDSALMTRSTAQSSGIWEYATYTDPSDTSPVPVFPNSLDDTRVTRDWYEKPLWDGRSMTNPTGVYGAAIISGEVTGDERDRKSMKNVRWKDEGSDNVPRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTP8</accession>
    <name>A0ABR3BTP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614215.1">
        <property type="nucleotide sequence ID" value="XM_066757831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990187"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06621">
        <property type="entry name" value="PKc_Pek1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="332"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="622" mass="66347" checksum="87B0F0C78681A110" modified="2025-10-08" version="1">MDNTLAPSIGKKPGGARPNPGSRPESGGPARPSGAGDVPRLIIPPGNVPGIHVDQAGEGGWHQPASLPSLALRPMRPSPTPSSSSRPKLSLTPLTPNIPASSSSAPSSASLAPPNRPALLNTHSARGYGEKSTPSLKLSIPGASSVGPGYSTENYYPLEQPDDIDALSSELKTPTPGRPPGGGLNLSLSSLSLASSEDANPTLQARGRDYDDGESSYGYGCVGNGLIGPGGDVISAMTEDIRQALSRNRFETGSDRGGARSRAGSLMSESSQATAGRDRSDSASLYSSASRRESPSASLSGGSARQSLELPRGAAEELNEQKESPVFDPEELMMIKRLGEGTGGSVDLVQDRATGRIMAKKVITRTSNPMVHKQLLRELEILNSCASPFIVEHYGSFLADHDSSIGILMEYCEAGSLDSLLGKMKKKNMRCSEHVLGRVASSVLKGLDYLHQRRIIHRDIKPSNILITRQGAVKLCDFGVSGELVESLAGTFTGTSFYMAPERIQNKPYSIKADVWSLGMTLHEIAHLRFPFPPEGENQSVAPIELLSYIVTAPVPVMIDDPSVGRVWSEPIKDFMGQCLIRSGTDRPYPWQLLQHPFIVASEAKKVNMAKWVAALCDWPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTR9</accession>
    <name>A0ABR3BTR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TFIIB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613695.1">
        <property type="nucleotide sequence ID" value="XM_066758293.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990668"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="74" mass="8041" checksum="409034F6D86BB620" modified="2025-10-08" version="1">MVAVAGPRAPGPKFGQSVVPNLNIKQICPNCRTDPPNIVEEYAKGDLVCSDCGTILGDRIVDTRSEWRVSICRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTS0</accession>
    <name>A0ABR3BTS0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614401.1">
        <property type="nucleotide sequence ID" value="XM_066758017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990379"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="326"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1202" mass="132694" checksum="797F83DA41B35814" modified="2025-10-08" version="1">MIVDGKAFIITGGLGSIGRAAAEILVEKGAYIVAFDILSPEEGEAKIKTFAKPNQYFYEQTDIADRTKMKAACDSALKKIPNGSLFGAIHCAAIAPGRPWTKSMTEKLDDFVKVMNVNAVGTFTVNALVADAINSQYPELDIFHERVSEERGVIINLSSVVGHGIPARSLTYGVSKRAVLGITEAAADFLAPSGIRVNSVAPALVISPIMLAGGRDKYFQAQLDQYSMFPRRFTEPSEIGSAIVFLIENSMMNAFHLKVDAGWKQLSSWALGDPRKISPLLDQCSLRMSSPSPSATGIRRRRGASASVSHEPQEPPRKRKQRPIFNCGECRRLKAKCDRKVPCSNCVRRKCPEKCIEEGEQVNSSRPAGNRTSPAEDTSLSPNLLRQRVLQLEKIIADSGLPVPGSAQENLNLSGNSLGDPSHPPPPVDGITQWDPSTQVSPAVQPSHSSGRSPNNSTQYNQYPISSVTSTYLQPLSRSNLPTANSSNLTHAVQTVQPNANEDRVTLHSSDLENLNHDVRSVSFPTGLWSRPAIHNANMVSPAANVSMTSPASSRNAIGADTSNGGDVDGLGHGTLMINRAGHSRWLGRTSGSEWINTQEMMEGSPSPPRTRLPSPTRFTDLADPTSPAAHPRSAGLFIAFPFAEVSRTITTAALLGKMPPKSEGVYLFQIYYRHFSWLFNIIPMAQLEAMLDRAYDLAESPHAVTSRMFPPEKLALIFIIFAMGSYYSLELPADDSSVEEYLSLSRCCMGKADFLNNNSIAAIQTLHIAAHLLLTMDSGKNGESAWPLWGLAARLAQGMGLHRDGERWNLPKDVVEERRRVFWEVYSADTMTSNCFSRPGSINPAYVDTQFPTIQRDSVEYFHVIRYQFTDISRSILDHAMFVEVPPYSHVLELHERVSAFERSIEFPFRCRPVLCGLPSVYPDSQEAVNESPSIDKRNYHRTLQQYALALNIAESLLFLHRPYFARALHDSHEEPSLSSYGISYMTTLERCNAIVVVASHLYSLYPQTAARHWFLWYHAFNAATCMGALILTNPRNVLVPFALALVEMTSDIYTSVVQLRNSPRMMKNLKWLEHLKSKIRVRLAQTPEENYSIGGGGGRNESDDTEVLGWRTRLIQRAGQGFPSVHTSLDTKIQNETNQAIRSDQSEPALEGITTDAGGVSFSESNFLNAFANISSTIESERCDRDSASFNWWLNGSPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU07</accession>
    <name>A0ABR3BU07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="12" type="ORF">I308_102477</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614491.1">
        <property type="nucleotide sequence ID" value="XM_066757022.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989334"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0250304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="230" mass="25799" checksum="B68498193BEFA6EC" modified="2025-10-08" version="1">MSLGLYIGRSILAFICLIVAILLRLIFLQHLKTTRAPYRSKDAKCSLGVFLGSGGHSSEMKALLSTLDYERYQPRTYIYCHGDDLSLRSVSDIESNKGALTSSKAYYLLSLPRARYVGQPLLSTMLSVLKTLYIATLRLFLIPLLKDPRRPFVDLLIVNGPGTCVVLVVVSYIRRILGLEYTRIIYVESFARVKSLSLSGKMIRPLVDRFLVQWPNASDGDNVIHKGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU12</accession>
    <name>A0ABR3BU12_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613473.1">
        <property type="nucleotide sequence ID" value="XM_066758071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990434"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF74">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-LIKE PROTEIN OCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21307" checksum="469D5A028BCEE490" modified="2025-10-08" version="1">MPTRVSPGITFADDNPSVVVPPINFSLVAPGIYRSGHPNRKNFPFLKRLNLKGIIYVEGSDPYRQDSLDFVQSQNLKLYRFDFSNESDLYTSEGQERLEALLKVLLDTRNYPLLVHDDTGKGSCTLVCALIRRFQSWSLTGLFAEGDMFAGPAGGAEGIGLGETGMEFIASFQPKLVNYDRTWRPDWADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU22</accession>
    <name>A0ABR3BU22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Origin recognition complex subunit 3 winged helix C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614627.1">
        <property type="nucleotide sequence ID" value="XM_066757158.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989470"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="2">
        <location>
            <begin position="348"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="524" mass="58279" checksum="C0E3E2EF26F54CF3" modified="2025-10-08" version="1">MESRLHSLSKGVFVIPFESTALDEEDRTNVHSSTRDTLDQLYETTFHIYERARTEYEQEKMNEQLSDIADWLERYEATTFLQLPQKTNMLPVAILQNASPSLPDGITSLDATCYTLLGRDSPDVAAALRSIAIGFTGDALGSGRKSSRASIDEVENWWQMNGKGLPLMLYIQDAQTIPASVLSEITYVLALHAGLPVRLLLSVPSAAVFLSSWENIEPSCIDMSILRSGRSRRGGGGIDAIIRSSSEAPFKISEDLAEELRSTETLLGGEVAATMKTLKWLLLYHSLSSPLALLVEKTKNSDQEQVVQSLLNAVKSNPANPQIPRRDLFELNPHPDMFSVLNPAPRTSILHSLSNPQNILPSFPGSAHENESSNRHNLTKRKAVSASMDSEKRKKARELENMKIGEDGQVLELKRLQTLFELWKSAGKTVNLYDWLDRFQGEDERGTEDNKEGSGTQTGCEQTDKDGNVERESRSEGPKRAAQEADRLHATFIRFVEEARMLGLIRARGKGRRADEVIKSVGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU64</accession>
    <name>A0ABR3BU64_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614672.1">
        <property type="nucleotide sequence ID" value="XM_066757203.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989519"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="384" mass="42782" checksum="F831EF429FD0F38D" modified="2025-10-08" version="1">MAHYQISPGKAVGIFQLGDTLWHVLDLLRTRKNEYPKFNLSWDPQRPHESAVVIHLPALTLYFPHPSQTLTLISFPSLASSNVTLTFETQLLYAPEQPLTRARIGRILGPTFADEGRGLIFPGIKFEMSAEGKGGREDVVRRLDVSGKEGECLSLPGQLISCKVQPNRGVVLSIVEEEPLEIVLGQTTAQDLLLDLGHPLRKFWKEDDRLEKMWGGISEPGYCFWNYFQYGLDFLISPQFKVHKILCYSNIPGTPLFQRYARCPWTVSTSAGALNLTSSVTTFHSSLSLRPSQYEEEIDEQKSSNSDETRKASKNGTGRTKKKRSVEPPVMVLDRVVEGGLDGVMNVGESRLIGYDGLVIEEDKSSGGICSVLVWRNEGAQPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUD2</accession>
    <name>A0ABR3BUD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614742.1">
        <property type="nucleotide sequence ID" value="XM_066757273.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989589"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46092" checksum="17F89C829A37C825" modified="2025-10-08" version="1">MSAAADNPHPHIDPSLVALAAQVQAHASAQAQRHVSLSSPHHHIPSAATDNHLGLGLPSEALGPALQIDPSLFEIEQVVNDVRRGKIRLGEDRRDEQESERSVQQPNDTAHQSHHQRQDDHPGEHGGIEGHGGLGDASEGLQMDDELDPTLREIVNSLTNAQQSSHLSGPGLSHAQAAAAIGAHLTDVEERERLQQSLQASLEDLTHASFGSLFPPNYTNSPGQGFLTLNDHHNIHDTEVDLSNPSLDVNAEVGSSSTSLDASSMAGPETSNSVKRGRGRPKGSKNKPKPGPPPPKPPKPPKPPARPKGRPPKQRTPAEQAEYELRKYEKELGIKRQKGRPRKFPGYLVREMRLKKNREEFNELMREYEEKKREEELTNLEMAGVDTQMDLGEGPSLVGHDHHVHDPHLHGEAYDTYVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUD5</accession>
    <name>A0ABR3BUD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102489</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614503.1">
        <property type="nucleotide sequence ID" value="XM_066757034.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989346"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="52"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="436" mass="48943" checksum="E1FC9D75366E6DAD" modified="2025-10-08" version="1">MGSPSSSARLTLLPSNYLSSQNPSSEITLQSLIDVSDRMANEAKEALPYNFDECSYNKGYLRQSVWSCLDCGEKGVCYGCSISCHSEHRLIELWTKRSFRCDCPTVSMQAEQSSGSKRRKCVLNRPEIQPSFPNEKNRYSKNFQGKFCRCGRDYDPETEEEAMLCCLGCEDWFHETCLNLRQPADTRSNLPQPLATDAQFPTPATASGGTSSVLATEEGEEEEEEDEQVLIPSDSYDSLICGECVSSNPFLTSQAGKEGFMIIEPRGSSWVVIGRSIRLDGEVEVGLGEKRGPEENEEASKRIKLDDGSDVREGDVSSNNKKRKGKGDVFLAHGVRNRLKFQLDIDTISSLPFPLEDEEIYEPPQDEEQEETIDEATSRVVSSLPRIQAIEALHGYQRLKEQLNDMLRSHVQSGKAVSKEDIEELFEKLKATRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUG0</accession>
    <name>A0ABR3BUG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614762.1">
        <property type="nucleotide sequence ID" value="XM_066757293.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989613"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF27">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="179"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="515" mass="58038" checksum="D657FE1EF783FD7A" modified="2025-10-08" version="1">MLAPIVAKIPPTIDLPRDHHGPPAKPLPSSQGPATPKYFRNPWPSYRTASVWDAYQAYQRGASIAPHPSLFQGSRFFSVDEPYSDQDEDDYESEPIWTESDSIKKRKIYIRPEFSDVRPGDEKDDWRDPPVELVEPDWGGNSKAGERVTWLGHAGVLVQIPWRIMDQHQSSRGGATCGIIFDPIFSYRCSPTQYIGPARYMDPPCSVSMLPEIHICCISHDHYDHLDYNTIMDLWKYHQATIHFFVPIGLKQWFTASGIPSHRVTELDWWREAIVSFEASPDVDYDPHYPSDDNKNKEKVAEDLTEIDTSALTLKIAFTPAQHRSGRSVLDHMTTLWGSWCVGVVEAADAGKVLERGMNDWKGFKIYFGGDTGYRYASAPEGDLNAICPAFQQIADLYSPFSLALLPLSTGSSLPFLRTVLSLSLDQYILTSSLHCSPADSIDIHLIIKSERTLGIHWGTFCDADEARGTRVDFGRCRRLYGVSREWDTIEAEKGRFVISDIGQTLVFPTTIDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUM3</accession>
    <name>A0ABR3BUM3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614819.1">
        <property type="nucleotide sequence ID" value="XM_066757350.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989671"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="58"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="303" mass="33205" checksum="D27D5166ADE22EBC" modified="2025-10-08" version="1">MENNEKIFVGCIGGSGLYHLDNLTFVKTLHIETPWGKPSSPITISSLPSGALIAFISRHGNHHTITPSEVPARANIAALKHIGCEAIVAFSAVGSLREEIAPGHFIIPDQIIDRTKGIREDTFFRGEGLVVHSMFGEPFSQKLNAFVAPRVEKILKETGDVVLHTGKTVVCMEGPAFSTRAESLMYRQWGGDIINMSVIPEAKLAREAELDYTLICTSTDFDAWRTGYEPVTVEEVIKVLHTNAGNSRAVAAGILQDVHDVVAEGKILTDIKGSMKFACVTRKDIQPETARKKLSYILPYFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUM6</accession>
    <name>A0ABR3BUM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_103455</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614334.1">
        <property type="nucleotide sequence ID" value="XM_066757950.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990311"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0250147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="321" mass="35662" checksum="6C1D7BE84FFE2722" modified="2025-10-08" version="1">MPHVAAPSRQALEKERLHRHAQQPGSSLSASSAVTSPSLSPLKLYLLAYNILSALLWGHLLFLTLSFLVTSHNSSSLLGRLTKSFSSVSHSCSAWHDFVNHLKGSYDYHNLGWWTKWTQTLAVLEVVHAALGWVRSPVGTVASQVASRLWTVWGVVEAAPEITHGHPLFTTMLFAWSLTEVIRYSFYALSLLSISAPVLNYLRYTTFIPLYPLGASSEAFLSFATLPALAPVVSKAVTHVVAKAPREIMNSRVGRELLWWCAKHGGRTGGAQKQWGWIEVVRAGLFLLWWPALYVLYTYMLKQRRKVLGKGKTVGGVNKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVD2</accession>
    <name>A0ABR3BVD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101724</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615055.1">
        <property type="nucleotide sequence ID" value="XM_066756278.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988582"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="27"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="397" mass="44469" checksum="6F00380549A156BF" modified="2025-10-08" version="1">MANASNHFKYKPIPIPHSADPAMFKDFGRQVEGFEPDNVTSEQMEEIMGMLYRHSILIFKNLKLSPKQQFEMTHSFDPEANVYGHGNNKTGNTKSSILHPDLKTIPHQPQVQLIGNGKVPMVYEGLDHPQLKHPHHKTFHKSVVSEEDDANGITRFYRWHIDAALYGLSPPKVTTLYAVKVPKGSYQTCRYDDGTGDELNVPLGGTAFVSGKNMFDVLPDELKSLAVRTKVEYAPHPYVWMSKAHALPTGLGLESEGLELPLEELPEWEESKVKIFPMCWKNPVTGALHVQVHPCGAYKLHISPSEGAALYPEGGVIDDLKTVREILYKIQRPGIAPGLVYSQDWEEGDLVIFHNRGLLHSVMGAFKPDQLRMFHQCNLAASSDPIGPDEKDVRTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVF4</accession>
    <name>A0ABR3BVF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase-associated protein LEO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615098.1">
        <property type="nucleotide sequence ID" value="XM_066756321.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988626"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="52520" checksum="5D8C960A22377CEC" modified="2025-10-08" version="1">MSDSESTADLFGDEEGSTRNSPIPQKSPSPQLSHVSNDEEQGVGDLFGDDTEEDEPQRRRRSTDTAASGSRSPHPLEYVEEDEEAVPQRQNVVTLPIPQWPHMTATDGKVWQMKFPAYINLDPKPFDSDLYRATQEEEPIDGAADPIAAKSMMIGVKNTIRWRWVTGPDGEPVRQSNARMLRWSDGSVTLQLGDDFYDVGPSQGATLARPSDPQPVPKRDDRPAVNSSTTFLCVGAAAERVLVTERPIAGQLSLLPTSMTSKTYLELVKHVGQQHTKHSKMKMLEETQDEEALQALLLKSAPNREAIKGVKSTVRRTSSKTGLGKGRKTRKIGYSDSESDAGFSADERRPRRRPERESVEYDDDDGFIVADSDEDDYASKKKKGKGKNKKRKGFTDDEESLDEMEEAERRIEERERERKRARKEKGGPSKKSREYVDTEDEEDEEAGDDDAEGEEEMDMDMDVESEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVK0</accession>
    <name>A0ABR3BVK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_101810</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615139.1">
        <property type="nucleotide sequence ID" value="XM_066756362.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988668"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="13">
        <location>
            <begin position="394"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="151"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="237"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0252419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="669" mass="74720" checksum="BE8D20C2FD285ACF" modified="2025-10-08" version="1">MVYDPIRDCDVPSPTPAVRRSSSLRGLLNDPPLPAVPIHEDAESHRPTLSNILNDAPRQRSMLPPQQPIRSPSMSLSPRSQNHSLPYPGSRPGSATGSTHPFGHDPRQGTLSPVLSARHMSEDHPRPTSSSSASGRRYTEPVVQTPVAAAHLGSSAYRPRQTSTPGNPSSSYAPRFTPQPTTTPSSPATSQHTPYTPHHSVPHRTIPYIPHRQSAPSSILRPIYPDEIAHLRQLAHANNPLRRKPARVPEPTPVPRRSLPSENDHSYFPPQASHHQLQRDDRRPSAPPSDISHRGPTPSSTPGAPHSSYSQYPPNWEVQTPGSNGNGNGNGDGDKSGRLGKRRARDEEEDGDDERNKKVVSGPVAGQMYSKKVAAVAEHYNARPEVGVERREFSPIIGLKKFNNWIKSVLIGKFAHRPRGKVLDVGCGKGGDLNKWKQARIGLYVGLDVADQSVQQAADRYRRMPRPGFDAFFYAHDCFSNPLSDVLSPELQIKDLYDNVTMQFCMHYAFENAAKARMMIENVSRYLRRGGIFIGTIPNAELLLERLNELPEHDEELRFGNSCYSIQFRERQHKGVYGHDYRFYLTDAVEDVPEYLVDWENFVSLASESGLRLVYKKAFHEILQEEKDSRDFGPLLGKMGVLNEYGESAMDADQWEAANLYMGFAFEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVK9</accession>
    <name>A0ABR3BVK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Csf1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615148.1">
        <property type="nucleotide sequence ID" value="XM_066756371.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988677"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029636">
        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21678">
        <property type="entry name" value="Csf1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="3">
        <location>
            <begin position="507"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2969"/>
            <end position="2988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="3074" mass="341391" checksum="510F12A7198F3B25" modified="2025-10-08" version="1">MAVPVNLLLLIELAAVVVASTAFLFYWNRLLASFIAFLIRLYAWRVHHAYISIGSLQISPLAGRLSFRDAEYHSSNISIRALTGHITWRYWKIRIRQEADSQSNNSRRNKLPCRIVMYAKGVEAFVYNRTPAYDAIVERMKKHENEAGAVKEGSHGHEDFEGEQGLRARLKNLARISTKDSSAKGTPSDNGHSSSGKSRKPRMRLTVSGCPPVTHELPAQVKPVKPPPSDSINWFREALPLELRVVTGSIVLGNDATPTLLIGDFKRAEGILETSQSRSFLDLYKMAVELKFHGANVLTRTNVDYSGPLLAHGKKVYDELLKQQADLANKPPSTISIFSGFHLLSRQFPFLYDPKFSTAPVPGLPTDKLWKGLARYRQPEDDATQSPRKEGGDEREYAKATNLLETPELTLTYYADIPGNVDLPPEYGIDIIIRKGTVKYGPWADRQREALQKAFAPALFFDSEPKARLRPGDTRVHTTLVLRVSLEDETVLRIPTRESSKLSMAMPTPLEWNAKRDWGMDVVFDAPSISLLRDHITLISDLAKDWSSGTTGGDYHHFVPNHYNFRVSLINYAFHLYINDYNIVDAPGSRDSNAFMDVYGPRLDAIVAVASTQYRPETSVVPFSISLSNARVELCIPIWDTHRTFGPEVVEVGQVGQLTASGSYRYYAVPGPDHQETLTLHLEGKHVKFKMLGWVLRRLFCVKDNYFGSFTQFTTMDEFLERFDHDPASVGDPVEEKYRPGRSDPYAVHITMNVEESLILMCDEIYNFSKGIALPVPQLQMAIKSVDQFMELSLNATPTYIAAAPQLMAVYERGSAPAVSGGEAVFIEGIELKASRLFGPKPRATTYLCLWEANIPKLSAFLTPGLLTTLQAVGRSVEYTFSDPDNAPDQNYQLKTPPDVTFFKFSINHALAMLTADSNAISLEALSGLTLDTSTWGTRSYSSNIGLLLPSVALNIIHHSPRRTWHVVSSATVGATLDVYNAPDRWQERVSAQQEFLKEQDSETGRVWYMYRGGQKPTGRHLNGLYLPMPMEENTVGVMDEEDIKSSLSFPETHDYNSNDSQASSSTESEPEESNPFMPRGKRNPGKPFVTIQETDNSSVSSAGDESDSASSTSSGSSSEISSPAECAFDMADVLASKLRHFQFAHNRYPSEIRLSTSDPSFGDGEEEIKGKGKMRDEMASGKVVRLVTHAAQVDLHPESLQSLSEILSVISAGSVSYEKRLDSLLVNQVQDVADSKIPEQQMFLDIHVPSAMMRVSGGEPSIALIGHIRHVKCNIHRFALINQRPVLDLTSSVVSISVSAMSSSDTPLSLRDIVGPMAGSPECLPLAHFVASAVIAGFHSGHGIRVHSKISHAHFHAVTPAITFGCAFTERWQTAMQKANFSRPKAGSDAAMLYHILYSAINSQRGTYLPSFAYVTPHGLHEQDSQLGNRRQTGWWLLTRFRDWLRGGLLDEAGAVGSISEMANYVASNLIQIDDSLVGAENLVRDQPFFKLAFNTGSSCVPETESNTPIDVFVYIDDASVRHYGRLLGSNATAMSYINIGKLSLGCAIVTASVEERHISQMRMIVALQTARLEVHDSILALARLIVHIPCKPEFETGKGESPLGSVSAINLVGNRPSAIAINIQLETLDATIIGGGLRLRSGSRQLQLTALTRHRLHSNPTSSYSTKESLSLTCGLIEIILLQPVENPTVITHSTDRVVISLKAQGWRAISERIAYADKPSTEVRAMTGLKLLEFESRPQLRALYSFIQQWKVKELPLYASAVDDMKGAIKTWTNGPPSKCNPVLLADLDITLEALHFQVRAAKALWLRWDVGRIYVVKSEKEKDIRFAVKIAPQIVGAYSSRRSKSNESSSLNLPSVTIIGNHRHLQDKPHIFANLQLGLFSGVLRPAILDRLLSLHQNLQDDISHLVTDWRKDVRKMKQKLHEQKSGRSPSPGVQKVNLNKIFYDVHVGIDGVRFGLRADDVPATILFEALAAKGRATNRYHHGQGLHWRAKVDHFSLSLGHLGEGYVSKYAEPFRRQRTASMTLDVEVEEIPASPLSTSQLIIHLSHVRTVMHVEALSELADLLKSWSSDLYILRDHRAREMAEVKQQTTKVLKKFESAEHVNRSEVSWLANRLLTVEIGGIGVAIPLVEGSLIEDGRKSDVPALLYSIRVISFHNRHNETARFRMQNMALQFIDKFDQSLPEHFRSDFHGSKNCMVVPSIESEAEMSSTHDAWHLSAHCSASDFKLTLSPDISDGVIRLIELFERGKEKIAKMEAQYKAEVARHAKETIASKYESPASPSARRQSQRIMVRTSFTFNSGTVELHRDLSDTEKTTLRSETRRSKGWHDTVVLPAVSLWMEYTGPKNEPLLVRQNEEDGSLLFNLAIHESRNLLRPTILPFFVQTANRLRRKTKRAQSTALDISPKTPIEASPAILQELPHRPTTRAMATRVQVRVTLRIDKSELRLSCASDSNAHVDLKWKSGGFFASTIIGDGSKATVAGTVSGVRAYLRHEFAEGKSCIEAGAKDMAFSIDYGFESLTDRKYLSIVLDSSLSAQFRLEQFSAWLAFAAVWLDNAPSLELPSRPPLVEASSSSPSAYTASTPRVTVNALVRFRTVDFDTNIGVTNAKLEMTPVVLRTSSNGVKAELELDLGVTQITAKGDISGEIRSENLVFRTNHQSSRGGAPNDRTVLNLSINAGTLSSNLSLQEVSVIRFTLDPATVTLADDWQAFAQDPTSQVLLSFAVKAGVFRSVVRLLSIPALVSKFYSLSNTIESQERMACHRSSAYKSKRLRKSTEPSPMAAAILHTARKAGQTFTSTSTVKTAQNMRFDLGGVDIGLFNSPPTDDHRGDFYRFMIGKVEADLERQLTAGNLPKRDLNLLMSYVKWISSDGVKAAREVKKHRNLEESIQAASAHGRKEIASLPLMTLTMDSIEESKPPVLVYDFDLVWGDGDLDIAIMPYFFEQVYKTFDKLIKGLDQEQITKAKRRGDGGAAKARSHATAHENDQACKGTALTFRRRLEGQRPLPVPRFRLLGEATGEAMAWVPKINAANAQLPIMVHRFVTSPLEDGMDLLLKLYEKQLPDRVPQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVV2</accession>
    <name>A0ABR3BVV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614994.1">
        <property type="nucleotide sequence ID" value="XM_066756217.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988521"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="5">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="165" mass="17561" checksum="15E2B4A530A12D43" modified="2025-10-08" version="1">MPPKFDPSEVKIIYLRATGGEVGASSALAPKIGPLGLSPKKVGEDIAKATGDWKGLRVTVQLTIQNRQAAVSVVPSASSLVIKALKEPPRDRKKEKNIKHSGNVPLDQIYDIARKMAHKSFAKDLSGGVREILGTAHSVGCTVDGKNPHDVIVAIQEGEIVVPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW68</accession>
    <name>A0ABR3BW68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_102015</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615343.1">
        <property type="nucleotide sequence ID" value="XM_066756566.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988873"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="208"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="301"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="393"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="485"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="577"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="669"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="762"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="836"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="1236"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="1290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0252623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1383" mass="148997" checksum="99F9DF542898840C" modified="2025-10-08" version="1">MSPPDAYPPVIATEGSTAFQSHILSLLSVISQHPSPDYPFPSSGDSTVQDAASIVANKNATLSIFPGKKTPAEDAIERAIIALGDRVWTSERTQAQLVKDLKREVPVQPGSDLLTPDWTPPAPNLSDSSPDPICPTCTRPVSSTETSSFTPQQIASFYHPFTAALSTPPPPLPEQMFFPQSVLAAYVSATSDSESAGDSGMSAEKELELLKAQVQDIARVCKAVATGDLTQKIIVPVKGQTMTELKNIINAMVDRLQTFAVEVERVSLEVGTEGKLGGQAVVPNVEGTWKVLTAVVNKLAANLTNQVRSIAKVTKAVAKGDLSETIDVEASGEIAELKTTVNGMVMSLRTLADEVSRVSLEVGSQGKLGGQANVPDVEGVWKDLTVNVNRMCESLTTQVRSIGSVTTAVARGDLSKMIEIEAEGEMAVLKNTVNSMIRQLTVFAKEVTRVALEVGTHGQLGGQAVVPGVEGVWDDLTTNVNKMARNLTDQVREIAMVTKAVARGDLSKTVNADVQGEILDLKCTVNEMVAQLTVFAAEVTRVSLEVGTEGKLGGQAVVPNVEGTWMVLTDNVNLMALNLTTQVRSVAEVTTAVAAGDLSKKINVAAFGEILELKNTVNNMVDSLRSFSSEVTRVAREVGTDGRLGGQAKVPGVAGTWKDLTDCVNIMAANLTEQVRTIAHATTAVARGDLTQKVVGVKVSGEILDLVNTINNMIDQLAIFAAEVTRVAREVGTEGKLGVQAEVENIEGTWQEITSNVNTMASNLTSQVRAFAQISAAATDGDFTRFITVEASGEMDSLKTKINQMVYNLRESIEKNTKARQEAEMANRSKSEFLANMSHEIRTPMNGIIGMTVLTLESELTRQQRENLMIVSSLAGSLLTIIDDILDISKIEAGRMTMEQIPFSLRVAVFSVLKTLCVKAAQNKLDLIFDVDPTMPDQLIGDPLRLRQVITNLIGNAVKFTTKGQVALSCRVKRYVTVADAVELEFCVADTGIGIKQDKLDVIFDTFAQADGSTTRKYGGTGLGLTISKRLVNLMSGDLWVESEYGQGSRFYFTTVAEMTSVPRDQIIERLAPWSGRSVLFIDTLGDQTGIVEMLQELGLKPIVIHSVNDVYLLQDQGLTVFDTMIVDSLKAAGELRGIEYLRYIPIVLLAPSNKPSGPSNPSFISLPESRRRLLALPSASEQLLSPIPVKDCLEMGINTYYTTPLSLQELSNAIVPALESHQIQPGDTVKDTILSVLLAEDNLVNQKLAVKLMEVAGHKIEVADNGEIALEKYKRRQLARTPFDVILMDVSMPVMGGMEATGLIREFEANEGVPRTPIIALTAHAMIGDKERCLAAGMDEYVTKPLRRGDLLASIAKVLAPKQSASGLEMPTLPIPANIYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWF4</accession>
    <name>A0ABR3BWF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615430.1">
        <property type="nucleotide sequence ID" value="XM_066756653.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988960"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="71765" checksum="5E25CD51CA2AAE3E" modified="2025-10-08" version="1">MLDLSVTPKHGNAGGRYFPHTGHLGVSPVVVQGRVATKLPPVCDPLLVKSISLRIKCTEYRTGGAFEGDLQNTLWEQSQLLLAPPNGEKYINVGDWDQQFKMAIPIEAATQGRSTMCIREYKVVWRMEVAIEHKPIHYVGTSITKAFALNLQNHQAPPLRPLSPIPSLYIGSDAYVSEVRLCVPHGVFGPGDSFHVALQIKPENPTTMIKKVTVVLERLITLVDTKSASRRDSFNDQLPPKRRHMHSSRSYSPTQSSKLSSILRRSLSPRPPFHRLRPDLHPLIDHSVQREGQVIRDKITESASTEMSSEGAGFWCSLPMSLPRRTGKWALGETHQTGLVSISYQLRASITFKGDRRTSPSETFVLPAVPVIVISTSTAERLDAVAAAQPKRKKLGSLGKGLYLHGENSSILDSESPLLSQEPPALSPVSGVATDIKPILLPPDKSQHPPPQSISFSFPSPPQRSPTVSSLPIHSLLNPETSKSPPNHQLLSPPPTRQGPSSLAEVADPESGSLLQLFHVQGSGRRISTTTSEEEEVQPSRSRQKLRAELPTTIAGFEWPSLPSLDALGMGLPHVPEDHRPRSRPRTAPIHSAFAISKNDIPPPLSGRFGRTMSGGELQQRPVTSAGASRSWRKDKDAATFAFALPEDKEHTDMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWK0</accession>
    <name>A0ABR3BWK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615246.1">
        <property type="nucleotide sequence ID" value="XM_066756469.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988776"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="316" mass="37317" checksum="6BAFF240BBA2356B" modified="2025-10-08" version="1">MPRLQILQHKSYHPYLEKNKERVRQDEARAREEELAKEQQRLDNEAEHRLTLLRRRANSPTIHDQQEEDLPSTSSRYADDSASTLLEKHRQKKLKEEKRERKKRERLDFDFPSQSDRKREKSDIVDHADLQEGGHFNFFAQFEKELNHKPELTLAEVAKKKKEQEKDPFTVYLSRPERETNPWYTDPDMRRYEEKEVGEEAEVRRDRERRKDARAKNRNDPLTNIDALFASHSSASRNGTSISKSVSLNSSFARNSTKGNANQSERQRALAMLAKSKPRVENWMDTPSTAYSGSRNWADDWERAKDQAGRRFFDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX53</accession>
    <name>A0ABR3BX53_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615682.1">
        <property type="nucleotide sequence ID" value="XM_066756905.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989213"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="83"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="642" mass="69755" checksum="90A208D4712F1362" modified="2025-10-08" version="1">MSVTSDITQVDGRIHSKLAAEDKPLSSYTLKKYPWRPYVTPFEEIIGKKYPGSGTNEDPYIVDWLPNDREDPQSWSGTYKWFTIFIVSAMTLAVALSSSAYSGGIESLMEELGASRELLIAGISLFVVGFAFGPLFWAPLSEVFGRRYIYIASYALLTLWSGAAAGAPNVGALLVFRFFAGFFGSSPLANAGGTISDVLDANQRGLGMAFFSAAPFLGPSLGPIAGGFLGMTSGWRWVEGFLTIFCGVLFIVGIIFCGETYAPVILRARAKRLSQVTGNVYRFRADAKKPLNVATMFKVSLIRPWKFLFLEPIVTILSLYTALIYGILYLFFAAYPIIFQSGRGWNTGIGGLAFLGVLVGTVISVLLSIFVSNPQYVKIAKKKGGRADPEDRLPPAMWGGALIVIGLAGTAATDGPDVHWIAPIIFGVPFGCGIIVVFLSVLGYLVDSYTIYAASVLAANSVLRSLFGAAFPLFTVQMFDKMGVHWGVALPGFLSLACIPATWVFYKYGAGIRAKCKYSADAERQMAMIMAARMAQSKQEDEEARAEGKEVIYPAGSRPEGEVQDVQPAEQEGGLGKVESRAGEYTGPQSAGGASLARVPTHLHHEWTIYEALADRDENDLADDERIKLQDLHSKFDNKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYD0</accession>
    <name>A0ABR3BYD0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101923</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615251.1">
        <property type="nucleotide sequence ID" value="XM_066756474.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988781"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="204"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="544" mass="60808" checksum="2F2557C728EBC753" modified="2025-10-08" version="1">MDQHEILHQCERMQEDELIVLESIYPGQIKIHPNPDNRPGRMLTLTLPVKLFSPTRISIASASNNGESSTSSLTLSHLPALSFCIVLPKTYPLLAPPAPISLHAPLCKGYDDKVGSWLLQKDLKEMEDRLRGMWDDDKEAVDQGQGVLWKWWDWVVNGDFLRETQRYTDNVLTLSVPSPLSPTTFLAALKSYDSCQIQNEFEQTAFPCSICWENRKGGRCVEMPGCGCVFCTECLGDCWTLAISEGTLEAVACPSVSCVKQRATNGKASLLDQGITAQLVEKVVGKELREKWEVFKDRRIAEIDPSFCVCPRPGCQAAVPPPAPSETCGNSSAPKAIRLADITKPSSYSPRLTTDGSAESGQSVSSTEDRWAAYRLCPKCNFSFCLYCSSTWHGPHTICSLPQASQLVLEYLKYPEGSKGRLAMERQRGKANLERMVSKWREDEMNKQWLHSRTKACPSCSVRVEKSVGCNHMQCGRCSAHFCYRCGQSIKPADPYKHFNTPGQPCYAKLFEAMDFEDVVDPVLNLEQFTEDDLLDWDFGAARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYD1</accession>
    <name>A0ABR3BYD1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Major facilitator protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_101683</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615014.1">
        <property type="nucleotide sequence ID" value="XM_066756237.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988541"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045438687" description="Major facilitator protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="36"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="314"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="593"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="644"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0252294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="75552" checksum="57D995096072ACC1" modified="2025-10-08" version="1">MLGLPSALLSTLLLSSSAILRSHAFRVPISDTDSLREVCSGMYGGKDAYIEVAFDQTSSGQVALVIYEWKDVQYLGAQNADEARTYICTTSAVRSGLCSDSQLGSFLTSFPDDVSLESSSIFTTPLKFSNDYTPTPTTDEDDDETLPTENEDQGETPTNVAGEPVQETGSIDDDMDEDAADQEEAQQIEELAETLGDGWRKRQVGDIVDDIAMAVTASDDEPSEDSGDWTETESSTMTESDSSTSTDQVSVPVYSAPITYAVPKTGYYCVGIVPVTLVNSRDNVQERRATHAEYSGMVLFRNNFAGELPAVEYPKIHFYLALSIVYFVLGCGWAYLCTKHHRELLPMQYYISGTIVFLIIEMLAQFAYYRYINKHGGGTASLAFLFVIAVLNAARNSLSFFLLLIVCMGLSVVTHSLGSVMHRVRLLTALHFIFGVMYSVGTVKVELDDASLLIVLLLIFPLSLTLTAFLMWIIVSLNGTIMHLQARKQRHKLQMFQRLWRILVISVIAVAAFFVVSSMSLSNRMNEDYTPNSWKYRWILLDGSLATIYLCAFTAIAYLWRPTRDNVRFSMSQELAQDEAEADAEDYEIDALENGRGRGFGGQQLLSRHDEDYDEDERKGLVRNGVGEENVVFAMGDDSDEEEDHVREHGQRGTEYRDSGEVGGSSELGRARSKDRGKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYV5</accession>
    <name>A0ABR3BYV5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100923</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615771.1">
        <property type="nucleotide sequence ID" value="XM_066755485.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987781"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="382" mass="43069" checksum="145B780802A51432" modified="2025-10-08" version="1">MSHAARKKVLLMGRSGSGKTSMRSVIFSNFSAKDTRRLGATIDVEQSAVRFLGGLVLNLWDCGGQSAFVDNYLSSQKDTIFSNVAVLIYVFDNTTSDWDSDITYFEEILLALRENSPDAGVWCLINKMDLVDKEDPKRKRYNERKEVLMGLNEKVEKEVEERGRHITCFPTSIWDESLYKAWSSIIHTLIPNISLITSHLTYLRDLCLCVEAVMFEAETFLVIAKSGSPLDCDPSDLDAVEAKAGAKDLDRQRFEKISEIMKDFRKVCQRNHERYQGFQAKFDACTVVLEPLSRNTIILLVSNDPRIETGAMLYNIYRAQTHIADFGAGKIPLERKCGICKRDAKARYVCKDDDDPSVPAWDSVDKEDAPLMQPSTGARCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYX6</accession>
    <name>A0ABR3BYX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-binding cassette, sub-family E, member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615821.1">
        <property type="nucleotide sequence ID" value="XM_066755535.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987832"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="70"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="343"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0253600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="68057" checksum="2ED437331286692E" modified="2025-10-08" version="1">MSDKLTRVAIISDDKCKPKRCRQECKRSCPVVKMGKLCIEVNPSDKKAFISEELCIGCGICVKKCPFEAIQILNLPTNLESHVTHRYAANAFKLHRLPTPRPGQVLGLVGTNGIGKSTALKILSGKLKPNLGRYDDPPEWQEILKHFRGSELQNFFTKVLEDDIKAVTKPQYVDQIPRSIKVPNMTVGKMFDRQTELPNRAELEEDLELKHLQSREVSQLSGGELQRFAIGIASVRKADVYMFDEPSSYLDIRQRLAAARVIRGLVNPTNYVIVVEHDLSTLDYLSDFICVLYGVPGTYGVVTMPYSVREGINIFLDGMIPTENLRFRDESLTFKISETVDEVQAPKTRRYQYPNMTKTLGNFKLHVDEGEYSDSEILVMLGENGMGKTTLVQLLGGKMEPDEGKDKISLRVSMKPQTISPKFPGSVRMLLLKRIKGAFMHPQFNSDVMKPMNIEPIMDQDVQTLSGGELQRVAICLVLGVPADVLLIDEPSAYLDSEQRIVASKVIKKFVMSSKRTAFIVEHDFIMATYLADRVIVFDGQPGKESWARKPEGLLTGMNKFLKSLDITFRRDPTNFRPRINKMDSLKDKEQKAEGAYFFVDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ07</accession>
    <name>A0ABR3BZ07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial protein with role in iron accumulation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615849.1">
        <property type="nucleotide sequence ID" value="XM_066755563.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987861"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="144"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="302"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="8">
        <location>
            <begin position="404"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0253628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="54945" checksum="F1E3FCFC88CE9AFA" modified="2025-10-08" version="1">MSLSSALRLGPVSGHRHSGIRQNRLLAMSQSLLVHTTTRRISTKVTCRKGLCMLTGRTSAVQRYAPLHSGLRNHTTKPSPSSTSKSLGHQHDHKHEHGHEHEHDHDHKHGLFHTHVHDHSEGAEQLMEALSSGKIDRGTRITLLGLGSNVALTLSKGLAGLWMNSASLLAEAGHSLSDLLGDFVTLATWRISRKPPTDAFPWGYSKFETFGTLTVSVILVGGAIGIGLHSYHLLLQTLLPYLATFPPGTLFNVIGTHLPASIPSPLLELFHSHGPSALPHEHGSATDHLHSHADAGAILNPHAAWFALASVVIKEWLYRLTARVASEEHSPVLKANALHHRADALTSFVALTSILGSSFGGWHFLDPLGGIAVSFFILQQGLSLSKVAMLELLDAGIDKKTQATIEKIVTDLVDGDELLAVRNVRGVKCGGHTNLDLTIDVPPSMTVRDSHALEQRVRDAVMSARREVREVKFHVHSEEVLPDGTRAKRKTVEKEGPTSDFGRDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZD3</accession>
    <name>A0ABR3BZD3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615908.1">
        <property type="nucleotide sequence ID" value="XM_066755622.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987921"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="153" mass="17574" checksum="8828FF19834A18FD" modified="2025-10-08" version="1">MAEQTEKAFQKQHLFQNAKSKGGKKIATKTKRWYKDVGLGFKTPNEAINGTYIDKKCPFTGDISIRGRILNGIVHSTKMTNTIIIRREYLHYIPKYRRYEKRHKNLAAHCSPAFRVEIGDQVTVGQCRPLSKTVRFNVLRVSKNKAAKGFAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZI6</accession>
    <name>A0ABR3BZI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616020.1">
        <property type="nucleotide sequence ID" value="XM_066755734.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988034"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0253799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="237" mass="26623" checksum="FD5A9EDF96D9786D" modified="2025-10-08" version="1">MAATFALKATLRKTMLRTLKGMSDSEIDKQSRDVFRILLDQNFFKKANSVGCYLSMAHGELRTNLIVDHLLKRGTSLYTPYIPAPPARTNNPSAPSPSSPSPEHDMRMLRLYTTQDLKNCPLDRWGIIDPGVERKDVEKSLREDAMSPKAPAMDLILIPGVAFDGECNRLGRGKAYYDRFLQSYTSTHPRPLLMAIALEPQMLSPGERVPTLDWDFQLDGVISPSGIVWRKKSEVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C053</accession>
    <name>A0ABR3C053_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nonselective cation channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616234.1">
        <property type="nucleotide sequence ID" value="XM_066755948.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988250"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF6">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="274"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0254013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="757" mass="83370" checksum="53E400E7365209A0" modified="2025-10-08" version="1">MSSSDSAPATALPQPLPDTVFPLIHEIHAIVTRTIDTALDWDQLNSPPINYSLVRPIVQRLAPKLEHRRPNGTDLTEPAALDGGELGVGKTAPPVHHGPSLGEVLYALMANRIQFITLSAGDLSSAPLQTSRAAFCELLAIKVLRSQPCAQGEAALVGQLVHAYCAFEGASDETWASLGEDKKDVEEMNSSALELAIVSSSKNFLSLPLIQHLVNLIYSGQLIYCPMSSRSIISDSYISEQLREVYVYNPYQAGWLDHSRLKVPKWRKCMEFMSFVILLALFVSTLAWRDLHHPTVVEIIYIFFSFGFILDEFAASKEHGWAVYAANAWNAFDLGYIAIFLLYFGLRVIALASHSTRTSDLAFDILACAACITFPRLVFFMIRENVVILALRGMVASFVSFMTVTILAFTGICFCLWTLGRATWTVKQIVWLMAQIWFGSSYLGFSASESFHPIFGPIVLISYAALCNVLLITMLIAILSNKFAAINQNAQREHLFQRVVKTVEGVKTDALFSYLPPINILAFAILVPLSWTVSPRTLHRINVFAIRLTSFPILIAISAYERYSYQAKQRAIRLGASTMDGVMDVQRASLLNSWLGGGSEFLIASAFEVGPPVIFSRPNQGGSTSESETPPKATTGPLVEDEDDGREAAGTTTTTFGATPTPKAVKKGKDKKKNKSNDSPLAKLFGRPTFSASPEETITILKDRDVNKGKQVKMVEQTVNEKEGGDVEQLKKEIELMRKSQLRMEEMLAGFLGGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C088</accession>
    <name>A0ABR3C088_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101421</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616263.1">
        <property type="nucleotide sequence ID" value="XM_066755977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988279"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="29"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="351"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="563"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="693"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="898"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="711"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0254042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="959" mass="106103" checksum="46A98C6EC7B8399E" modified="2025-10-08" version="1">MSSTKATNSSYTSFSDGRSSSPAYRYKPVGIVNEFNTCFLNSTFQALSATASLTSLLYASPVSPLKPLANSILPAPVVPRSQIPSLHQEALEPKLYEKLPITIAFISALHEGYRRKDRYIGDEGCMRLTNMLHTVSAKHPQYNDYDQQDAHEFLRHLLDLMELEEKDAIKILQPKGLPDKGDRRKKRANIQPSQADIETQGLQPQDHISPIVSPLPSPAHSLPVTPSLSARIDPMSRVKLEDVDLSVVTGKVLTEEPSCNPDEAEVKVLNEENGNHSVEKSVETLVENTVNEKLTPFVDVLFGGLLASVVVCEKCKALSHTYEGFLDISLQMPNEAERPRKRDKVIAFAQRLMPGRSSTSRNSPEIPPTAHIQPPPSALSDNELSDPETNPNTTHFGRRKSVSISEGEGASLGRTGSRKFSIFNRKKRAHIRPGSASSSVNVTPTLEAEKTPTAPPSPVLLRERLHHHRGHHKHQVAPTPAQAAYIARILAPPQVAEQHDPIARLRAAQSGSGPVDNEPTKVETGLERCLREFTSVEVLEGPNAFACHKCWRIKHGRYDHHEATLKEEDENNVPGDSTPSLSTSSGSPLRHPARTTKNSSQSEGTGNSVAQHLSLSSPRLPSSPISIQSGSVSDSTVPRNGHSDRVGRNPSHGSLSSEAYVRTNVRTHSPLRRQVEDDDTMVDLMTSTHVDQSFTYQDSNSGSIILPSEADTGEDADPGDGSESESDGLSDSESESEDESGKPKKKRKSKHFVMGRAYKRYLIAKSPEVLVFHFKRFKQLSMAFNTFASLKKMDDFVSFPERLDIAPYLAPNRKDYKVSQTPNGPHAPYMDWPNPMQGPEKVESVMYRLYAVVVHVGEMTSGHYVAYVLVDPEMVFGKDQHKEGGDSSEASMNDMTLQDAPAKRSNTPTNEEQKSTRTGRTPKKDRRVWAFCSDEYIREVDVEEVLSAKAYLCFYEKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0I8</accession>
    <name>A0ABR3C0I8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616160.1">
        <property type="nucleotide sequence ID" value="XM_066755874.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988175"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="181"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="367" mass="40653" checksum="EF4DB93812740A1A" modified="2025-10-08" version="1">MEPPPQHSLAGRGRVATLGMFIIDHFQVHDEDGNPVPTDEEAIGGGGIFDKGDDFPERFVHDLKSLGNEMVWFRHREGRTTRALNIYSGRRIGEGHQSFKYLSPQLQITPKDLVMPPSPFATPVPPEWIHVVCGVPRMFDIVDELELLKKQRHSSTGLSPIKSRLVWEPLPFSCIPEELNSMMSLSSRIAVFSPNLLELQSILSIPHSSPPIHSHVEIAARQFQTLLLNKSSGSQLPAIIVRAGELGAYTLSSSWTGWVPAFWTKADQSRIVDVTGGGNSFLGGLAAGLLISDGDIRTASIYASTAASFAIQQRGPPRLQQLNGEERWNGEVVWDRLNEMARRVTQHEGANCRLYRTCQALDLKNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0K2</accession>
    <name>A0ABR3C0K2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616175.1">
        <property type="nucleotide sequence ID" value="XM_066755889.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988191"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="49"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="252" mass="29643" checksum="98248E548ABAA1FE" modified="2025-10-08" version="1">MSHEWDELMTLNSYAVRSPSPSDSPFQDAISTKSPPMSPPVFSKVKPTNILGVFGLSVRTSERDLQDEFSRHGEVEKIVIVYDQRTGRSRGFGFITMRSIKDATQCIEKLNEFTIHGRNVRVDYSATVRPHDPTPGQYLGPKRPTISDERPLSRDGRYDDFLEIDESLHGASHRHHFNRSKGRYDIRDDQPLYRLRRLEEEDSYYRGRHDRRGTHEYRYRRISLSPRRNTYETSPNRRGRDTAYESRCRRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0R2</accession>
    <name>A0ABR3C0R2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616235.1">
        <property type="nucleotide sequence ID" value="XM_066755949.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988251"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="38"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0254014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="584" mass="62942" checksum="ACB5D01D05432472" modified="2025-10-08" version="1">MSSASDPVAGTATEQTPLLPATTHHNIAGLTPSKFRLVCASLWCATFLVAFDSTLVSTLLSDIGSAFKASTQVSWLGTAYLLSVCCFTPVYGRLSDLIGRRNAHLTGLTLFTLGTFGCAIAPSMPFLIVARFLAGAGGGGVASVSAILMTDLVDLRHRGLYQGWANITFGVGAGLGGPVGGWISDNFGWRLAFHIQVPLLVLNAILIHTFVIIPQQEPSPASPSNSSSRSGILDALPTSKPANGLQTWKTKLARIDYLGSFTLALTVSSLLLAMSIKTSATKFDGSDYAFSDPIIWGLFVCSGLFAITFLLVESYYSPEPILPLKLLTRRTPVAIALSSFTMVTVQFSVLYNIPLFFTIVQQRSSSSSGAHLLPNSILIGAGSLFVGWIMRRTGKYWWLGVDCAVLIVVSSIGMCFWKKDSPEWLTWIAQAPGGFGYAGVLTTSLVALMTHVQRAGKGETAVATSMTYLFRTVGQVLGVAISSAIVQSVVQRDLVRTITGPEAQDIIYVIRHSTSAIQTLEPQYKIPAIQAYDHALRVVWIFNLVLSIFTVLTLMIVKEEEMPDREAERKRIGQTDGSAFEGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C131</accession>
    <name>A0ABR3C131_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endothelin-converting enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_101483</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616325.1">
        <property type="nucleotide sequence ID" value="XM_066756039.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988341"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="135"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="271"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="706"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0254104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="916" mass="101658" checksum="278D2B982CF0927F" modified="2025-10-08" version="1">MAEPRASTDEESAPLLDTQTNATTPSVFSRPNTSREKALAAISVLFLLLASLFIGLFAGAESSYKKEKGKHGGGGGGDWATVTETKTDTQTETVTTTTTHVSQPTGTPAPSICLTPECVQLSASILSALNTSVDPCDDFYQFATGGWQASNSIPEDRGLYGAFNEVSDNNKKLILKVLGSVSDEKPGKDATVDERNLAKLKAVYISCMDIDTLNDIGEKPLIDLVEHVLDIFGEFDVSPYVDDALPNAEPYEGAYDETYRLPDELIAAAAKVEEIKELKKAALTPDAKREKAELELSGSEVDEARRHKLTQTLAWLHSRGVQGLVNFAIEGDAGGEDSQIQSLWLYQAQGGLPSKEYYDEAPILDLYHSVIHDILTELAQHTSAGKEKRGWVEDLVAVAMEEELIGDESWPWPWPGKGGDGGDDDRRHPPREPIDKRMGKLASQVLKFEKDLVKAGADPEYLYNPHYAYNPYSISAVSHALPFLDIPTYLSTFAPRTFPENITVTYPPYLNAVTKLVEQTPDEVLSGYFVTRLALAYADALGPKTEVKKSFRRLQEVLKGIKPGTEENRQDVCLAWVDDIVGFIAGREFVREAFSPEAKSEGERIIRSIVSAFHAKLPHISWMDEESAAAAQKKAEAIIPKVGYPLLPDTTKPESLESWYARVDIDKEDFFGNVLRSSLVEESRIWLSLGRRRSRDSWEMYPQTVNAYYSPPDGEIVFPAGILQPPFYSLSWPAHLRYGAFGAVAAHELTHAFDNSGSQYDEKGRLRDWWTKKTVEDFEKRAQCVAKQYSKYWVYDAEGKKVFVNGNLTNGEDIADSGLAQAYTAWKSSVPDGSSSERLPGLDYSDEQLFFLAFARVWAQLIRPATAVSRIRTDPHSPPYWRTVGTLRNLEAFHKAWGCKAGTGMNPPKEEQCELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1G2</accession>
    <name>A0ABR3C1G2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_101374</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616216.1">
        <property type="nucleotide sequence ID" value="XM_066755930.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988232"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="282"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="113"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0253995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="565" mass="63220" checksum="ACFBDEC8CA32BA32" modified="2025-10-08" version="1">MSPSTPSTPHGRGSGSEPGTPAPTVAVGGSYTIDDVVPGVKIYVIKPLSNGQAEQRRAEILSTRPKPKPSAFAPPPHPDAPPPDPRDDTEYYVHYVEFNKRLDEWVGGSRLVLSKEMEWPKAKDDPKKKDRPGKAQPSKATPSRATGSPIPSDSLLKKAANKAAMAAGKAAPGKAMPSSKLGRASKIGKAGKIPQKRKAKTETDAEAEEESNEDNDALDEEEDLDEDGDVTLVASDGAIDPSREVVAAPSNPRAAPQVFSKKQEIEKLRTSGSMTQSHSEISRVKNLNKLQIGKHEVETWYFSPYPIEYAHLPVLYICEFCLLYYPSATQLRRHRSKCTLLHPPGNEIYRHEGISFFEIDGRKQRTWCRNLCLISKCFLDHKTLYYDVDPFLYYCMTIKDDYGCHLIGYFSKEKESAEGYNVACILTLPQHQRKGYGRLLIEFSYELSKVEGKLGSPEKPLSDLGLLGYRAYWQEKIVELLLDSDYEISLDEIAQKTSITHGDIMHTCQALQMIKYYKNSHIIHLTDAVIEQHKKTKAKPRRAINPAYLKWKPPVFSRAQLAFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1G4</accession>
    <name>A0ABR3C1G4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha 1,6-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615832.1">
        <property type="nucleotide sequence ID" value="XM_066755546.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987843"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="63725" checksum="5E4C842775C6A0A7" modified="2025-10-08" version="1">MDPEKGLLPTSTSSSTAPTRLSSPILQHVSFAHNLSPLRQHQHPSTLPHIGLRKRRLLSQIIIALGILSIIGWIVLGENGMRDVITVVGSKGQGQQRPHDAPVPGIILGTKGKPMPLPDIEPMEPPADVQESSQSSSAPQKGGEDDGEELSFAEKMAKLSHISPRKWGLDLSSAKLLNGLAPWPSNPPINESAEALSVLGHFADNVYNYGPDTIKEYRKHLRTFIDVGWPKELKDVLTNGLDRFTMSDAGPVEGEEGYWDWDREKYVWQTDKDLRHVESEEVASWKDWRMDQEGWKWDLLTDDDANKWVKNNLAGTKIEEVWDNLPSGILRADTLRYLLLLLRGGIYSDTDTVLLKSPSHWGQGARLWNDGEGWLTEDQKKRLEEGTQIEDVLGKPSVIVGLEADVGDREDWHDWWPRPIQMVQWTMASTPSHPIALSAVLRILHSTATAVSWAHENARVINILKDQGRYKDAQNLASVSVLNEPKHGGPVGVMAWTGPGVWTDAVLSYLRVKYGVKWVDFKGTQEPLRIGDVVILPVTGFSPGVGNFGSQHRTHREAMVEHRFAGSWKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3P5</accession>
    <name>A0ABR3C3P5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616509.1">
        <property type="nucleotide sequence ID" value="XM_066754608.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986886"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="955"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="398"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="520"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="692"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="309"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1034" mass="110785" checksum="1E3055A323C22E22" modified="2025-10-08" version="1">MTVNLNREDISLQNLGDERSENGIVKEDERDRALEEEDGGQMGHGDASELGEDDAQGAREEVENKKGNGAEEGHVNDEEVAEKPAETAMEEVGPEENRDAAIDAVHQVKDGGDEEPIEEAEEEDFEGKKEATSGGVKKVLKSGVFGAGTPKPTPAPKTAAGASASARLSRPSLAPVRPGAAAVKTTASSTSKPASASSTAARTTMASRAPVSTRPGTNGVVTRPTASTATSSTRPRTTTVASDRTTGTARPTTTSTTSTAAARARAGMTKPPVPTAASVRTATRPTSSTTTRPTPSTTSALARKPEAKPASSNATAARTARPSAASTTSTATRAPLASQRTGASTAGTTTTRTGVTRPLAGRASMAPTTSTLRAATGVLPKTRAGSGPSAAASGGKEVTELKTKVEALEKSMADEKTKYEEKIAALAQEKVDLEESHGKALEELGAQLANATDKAGSDAEGKIAELTALHETQLKEAEEERNRLMMEMVSKLQKMGAEYTSIQTQLESARSQITSSETKLLSVKSSLQNAQDELVQLRTTASDRDTAFAELESSKASLQTRLNELETIKSSLEKKLVEGGEEAEKSLANVTGLGDKVKELEDQIAELENKLGSEKDAWRAEEAKWEETKAALEKEIEDLKSAGEGHAEELSRASSVAETSKEELSALRIAHEQLATTYAGLVEASSRHPEDVENLQRQLKEATDKHEALLLEASSTTNNQNAELEAQIVELKKEKEEREKEVEVLKSTLEEVEAKVELLKNARREGEEREMQLNQIIARLEAQVEESKMEFENRYAAAFDDAKRAAGEEHDREVASIRSEHAAQLESLRASHATTLAALKSDHSNQLSVLELSLQAANAQVEGDQVKLEGVVEERDVLVEKVKRLENELESAGGKSNEAETEVEAELKKVKAELQHVSDELAGALEMSEMNKTHFEQTLLAVHERQADEIRAAVESREQQYAEESAQGPDKLRVPSTPPRGEMPSSPSMARLHEAHNAKVTELESEIARLKAELGRPVAASEAVDEYDDETLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C415</accession>
    <name>A0ABR3C415_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616655.1">
        <property type="nucleotide sequence ID" value="XM_066754754.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987040"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="125"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="316" mass="35797" checksum="518F3E1D6DE8F074" modified="2025-10-08" version="1">MLPARVILHSARVLPRLIPFASPSVGCLFARNRTAFCPQILPTRPYSSKKKNKEIELSEWEDDLFGEETSTRPGQKEVVLEEEVQLNEAAFYKKDPPFPTKETPIRPRLPGSIKKLNRILSRQRKVEIPEDELEERFVRGRGPGGQAINKTNSSVSLTHIPTGIRVQAQPTRSREENRKVARRILAERLEVLRATGHLPGMSGLEGIEGVSVDMGGEEGEEGGEKLSKKERRKLEETRLSETYTKAEIRAEKERRRKANRAKKAKKKYGTNDKGEKTLAKEIEDDGSEVDQLEMDAEVTEQGVEMDEEFKRARKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4G1</accession>
    <name>A0ABR3C4G1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616518.1">
        <property type="nucleotide sequence ID" value="XM_066754617.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986895"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="174" mass="19290" checksum="B0A49D0FBABFCAAE" modified="2025-10-08" version="1">MTALLLTIALALLIVDLYWSSVYVLVNNWESTLLDARKEQDLLKRGLLRDNGILRNLHFLEQAETDDNLKSAAERRSASAKDPPRYVERLRELVASPGKVEAQVDSCAPSAAQIPADNFNGFPPPGGNANFEDWPIDLFHPIAEYTKGMIDWDAAQKMDASYTPSYADVPSDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4L4</accession>
    <name>A0ABR3C4L4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100373</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616845.1">
        <property type="nucleotide sequence ID" value="XM_066754944.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987231"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="70"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="260" mass="30472" checksum="B90C3F6E7E476072" modified="2025-10-08" version="1">MSDPNDVWKDTSATNGAPVDAYARESSPRRETRGDDARSPRRDRSRSPARAPERADRGRGDDPNTANQGNNLHVSGLSRAVTERTLEDLFSQIGKVAKVQIMVDPHSQESRGFGFVMMESREEAQAAIDQLSGQNIEGKSITVAHARRGRARTPTPGRYHGVKADSRPHHSSYDRPYQPRSYDSRYYDRPPPRAYDERDRYDRRDRYDDRRYDDRYARDRYDDYYRSSGGAPDPYYYRSERDSRYERRDERPRYDERPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4Q7</accession>
    <name>A0ABR3C4Q7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sulfite reductase (NADPH) hemoprotein, beta-component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_100145</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616623.1">
        <property type="nucleotide sequence ID" value="XM_066754722.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987003"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein,Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01540">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011786">
        <property type="entry name" value="CysI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02041">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="13">
        <location>
            <begin position="631"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0255346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1375" mass="149056" checksum="F969BA5FB8B96823" modified="2025-10-08" version="1">MSVLAAISSLPATSYYHPIAQIPAGASKLNPYLPLPQSSTPAVLFTNANLLHSLPTASLNRTVVHVFDAEEIVTPKGAKAVSLISRSAQNAYDHALLALRLAQDQDAVVYHFIPSGLEGEVQTLENAQAWLSGPLDAPNVSIGDGAEPSAEAKLVAAYDSISLSLLKLTRRPQRPFIHNKAESSRLVVNFLPSPVLAENTIDIVLAIPAPKEKLSSSLSGVQEVVVVEAGSGKYGPAWASVVDALEGADVTIRSILVGASASPEEITAAITGDAPITRIGKPLSYNIPSNAITVPSPESAYTELLASSPSPLEILNDPSHLAANESTSPLYAFGKAVAIRKERARLVELAKKVLKAPNTKPEVHEAISAWLLIRDEKKGAAEAGKKVEAAIGAGKGDEKEIVELGQKGHWEKRALWIVISNSWAVDLASSGLHHALASGLDINLLVYETAASPFSPNAPAQPSKERKKDLALYALNMGDVYVASVAVYADYAGVLNAMREAENYSGPGLVLAYLPWGEKEDGQAVSDSENAGPLERLRETKRAVSGGWWPMFRWNPSLPDNKRFSLDSSHIKAALSEFLDRQSHLSQLTLATPAIDPSVTSSAGTELLAARKEKARKAYDALLNSLDGPGLLVLYASDGGNAEKLAKRLVGRAKMRGVGASLRVLDEVAGSIVGTLGQEQNVLIVTSTAGQGESPLNGREFTKALSKLSPSDELKETKIAVFGMGDSHYWPRPEDAGYYNKPARDLFPKLLSLGCQELLPLGLGDDSDPDGVQTAYKPFEASLWRALGVDSVEVTEEKEEVVANEHIKIASDYLRGTILEGLADKSTGAISASDAQLTKFHGTYMQDDRDIRESLKAQGLEPAYSFMIRVRMPGGICSAKQWLDMDRIADEHGNGTFKLTTRQTFQFHGVIKSHLKKAMQAINKSLLDTIAACGDVNRNVQCTVNPSLSKTHATVYEFSKAISEHLLPATNAYHEIWLDKKKISGDAVQPFDSDSEPLYGPYYLPRKFKIAIAVPPDNAVDVFTNDVGFIAIVENDEVVGYNVSVGGGMGVTHGNKKTYPRLGDVIGFIAAEDGTKVAESIMLVQRDHGNRQDRKNARLKYTVDRLGLPKFKAFVEERWGKKFAPARAYHFDSNLDHYGWTQGYDGKWHFTMFIENGRVEDNSRHQFKAGLREIASAHKGTFRLTANQHLILSDVAPEDLDEMKRLLAKWGLDNLDHSGVRLSSSACVAFPTCGLAMAESERYLPVLIDKVEKICEEAGVKSDDLVMRMTGCPNGCARPWAAEVAFVGKAPGSYMMMLGGSHLGTRLNKPFLESASEPEILAVLKPMIKRWALERHEGERFGDWTIRAGYIKPTTHGTNFWEDAFPAQAGTTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4Y9</accession>
    <name>A0ABR3C4Y9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA repair and recombination protein RAD54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_100474</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616944.1">
        <property type="nucleotide sequence ID" value="XM_066755043.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987332"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="250"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="580"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0255667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="818" mass="91992" checksum="A37A175857DF6316" modified="2025-10-08" version="1">MLRRTIQRPSEPPLTSATSGGFGIVSTPFKIPKSSAPKRESTLPPRKRKSVSYKEEGPCDDGGDEEYDNEGRPSKKGKFAMGNKEYGSDGVLGDMAKWCNRKFPVFQPKDKSGVFTKSFSIPIMYCPKTSEPIIHSLSHASLGARRHPALVPRPLHDPMDDHAIVLFDPTIDDKPNPEDINTIEPLEEMKKKEELNKGPHRSLKVILGIADEKKNKQVVKVPVVIDPRLSKVLRPHQIEGVKFLYRCTTGLIADGAWGCIMADEMGLGKTLQCIALLWTLLRQSPIAGKPTCEKVVIACPTSLVGNWANELVKWLGSGAVNPMVVDGKGGKAELIPAVRRWVQAHGRNVTLPVMIVSYETLRTLQEELASCEIGLLLADEGHRLKNAETLTFQALTSLKVQRRVILTGTPIQNDLSEYFALLNFANPEYLGSKLDFKKNFESKILRGRDADATEKEKLESDAKLKELGGLVSKFIIRRTNDLLSKYLPVKYEHVVFCRPSPLQASLYNLFVTSKDVQRLLRGKDSQPLKAIGLLRKLVNHPDLLNLPEDLPGSETLLPDGYNGKGRDRTVNCQYSGKFVVLERMLDHIRHHTNDKIVLISNATQTLDLMEKLCRSKRYGYLRLDGSMSVPKRSKIVAQFNHPESKEFVFLLSSKAGGCGINLIGANRLVLFDPDWNPASDQQALARVWRDGQKKECFVYRFQTTGTIEEKIFQRQCQKQNLSACVVDEAEDTARHFTQGDLRQLFKFNPETLCDTHDTYKCKRCREGKQFVKAQALLYGDASTWNHYPNEELGKMHDDLLRAELGLPEVSYVFQYISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C512</accession>
    <name>A0ABR3C512_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616994.1">
        <property type="nucleotide sequence ID" value="XM_066755093.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987382"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="138" mass="15903" checksum="9ED2E2D6C1CE4EDF" modified="2025-10-08" version="1">MRHNRRSLQQNDGHVTTPVILSALSKLYADKPGYYLRGKKARIFITANTCCMFCNRLNEKLHDARRTLYACYGERRRSNLGINEARSHAWIKRRRRATRPRRLNKDLLRMLLLLADIAEGCVLVVVDVPPPPPVPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C522</accession>
    <name>A0ABR3C522_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription elongation factor Eaf N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100394</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616866.1">
        <property type="nucleotide sequence ID" value="XM_066754965.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987252"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027093">
        <property type="entry name" value="EAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970:SF2">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="360" mass="39382" checksum="56B825B0A7024C6D" modified="2025-10-08" version="1">MSVKTAPGVPHGTYNLDLSSLNHPEDELIAMRYAFKPASITHTTSGTYYPSQGSSSSQPVQVVFDINGSQIFDVREETMKGRECVMIFNEENNAFELYPLSTTLHLTLNRNASHTYAASTSSTSSSSSVPLAVKLHTAQEEPPEISNPAADERDEEGVPRPTKRVKKAIVEKRERNKGTSPSQEDVSRLKGNRGVGKGGKSLPRNKPLESAPIPVIGSARTRSATTNVKNKGGKGKSTGEKGKTKGKKAETTIHRKVKSAEYIEDSDEEIGASEEVQLPPSSARKPRPRGKEIREQEEEEEEEEEDAMDEFANLLGQSLAEGYDDEDDEESESEDEDDDLGGARLVVRQSGVMDDGSEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5C6</accession>
    <name>A0ABR3C5C6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_100629</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617097.1">
        <property type="nucleotide sequence ID" value="XM_066755196.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987487"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="151"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0255820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="203" mass="23012" checksum="AFB0111BBBA93CF9" modified="2025-10-08" version="1">MTLYYSICFGLLMAELSLFCTIVCPMPFAIRKKMFHFLSENPVVAKIQYGLKITFIFVAVLFVDALQRMIRIAQEGATAKMKQDMADARTETNYAARRFYAQRNLYLTGATLFLSLLLARVFYIILDFIQVQESYTALQAKTAKASGAAGENEELRNRIAELEAKERDFETLKKQASQQNTEYGRLADEHNKATGAVSDKKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5H7</accession>
    <name>A0ABR3C5H7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase II subunit RPB7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617150.1">
        <property type="nucleotide sequence ID" value="XM_066755249.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987541"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="78"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19431" checksum="7382B51E77E2D119" modified="2025-10-08" version="1">MFFLRELTHTILLHPSYFGAQLEDYLRQKLYEDVEGTCSGKHGYIISVITITDIGEGKIIPSTGQAKFKTRYTAIVMKPFKGEVVDAKVVNVNKMGFFAMVGPLQVFVSCHLTHSDMKFDPSVSPPCYRSNDEIIQKDTKVRIQIVGCRVEANDMFAIGTIKKDYLGQIRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5K8</accession>
    <name>A0ABR3C5K8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617185.1">
        <property type="nucleotide sequence ID" value="XM_066755284.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987577"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF13">
        <property type="entry name" value="OS03G0201400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="560"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="595"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="668"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="745"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="88083" checksum="A37B842A698A3914" modified="2025-10-08" version="1">MASGFGVRAVRSLGQAGRISSGRKLCPACLVFRDIHARQYNHGPSSRQARSSEFAPAPLKPTKAAPKAKVADSLLRAQFQTIFHNPTTTIDARQALHAAYPLVFRRNIRALLDAHTKTIPLIVAPILQQADATDEERRQALVLLGHCYGKIAVDLLFVGPEVQHVAEVFAWGLMLEASRHRQHVNVNVNEDEREKWRMLRDMLESVLKRLANNGATPVLPAPIVAAWVVLRSKTGGPSTGPVVPENCVYVWPTQASIEAYLSKVIPAGETVDSYKKEIETLLGKSEAIADRIPRSKDALDTELMSMRNRGDWLGIMNLWGRVQAGMRDGEGEGAGAGQPHGGGSGQVGILDPSPDVRFPVLASFLLAFKRPFARSTSSSASSSPPASATIVHPPPKSFNTYAAQVLAKCPRPLPRTIAYTLIFLRVRPDDNAGLRAGHEVMSLDMDERRDAGENALENLKATWKETGERDLKMYLMYIEGLGRLGDLHGLKQAWNELVRDDECRRMYLQEERLSSKAPFPPIHALNQMISACLLIPTEGPPLALDLFSQASRPDSAIPCNLITINTVLRHYAREANIEAMSALFSKAGELGLEPDVVTYTTLVQGLLRARRLDLAKGAMDAMQNQGIVPNERMCSMLIADLAKPGTRVGLEHAEEMLKLMHQKNMQTNEVTWTALASGYFRGGWEADGWEALARMNRLGIKMHRVGYNMLLKQAAGSIDSHGGDADVETVMKLWRRMLHDGVVPNSDSYLIVLTKLVQMDRKKEIEEIMREMRQRGFRPEKGALVRIMESINRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5M4</accession>
    <name>A0ABR3C5M4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617194.1">
        <property type="nucleotide sequence ID" value="XM_066755293.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987586"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="486" mass="52593" checksum="57EFAB17AA319679" modified="2025-10-08" version="1">MSSTFSFSYPEEASTSVATILFQSSSSLPPSPFSPPRPAPQPLKQDCKKLGRHIAMKEPSQCGLFTVCEIPETERELQKQEAMEAESLANEGSIYSCTSAIRSSEAFCLTPGRDKLELEVYNESMTTDADLTILQTPSAESTRRLHRLSWSSSDSDERPVVTLLMGMENEDPFLCWSHVPFDDGENDDDFEMSEADVSRTISQPLFSTPPSMSGSKLFSRRAPPALALKSRFSLAQSSMTSPAVSPTLIAHPVSAARPTADSDILAPRSTTSATSNYLMPPLPIMSSNDWATELRKAEDIEINVVAPTTPTLVRGRKSLKTSSQSPISKNIDLASALEDLLSSCGEATAADSLFCASDGGDFETKALDFPRPSNGSDLSPGGSLHTPEKKSKRSAAPYAPRKPSRAHPHSQIPPKMEGGRVSPKSLEGDHSFLTYLSRNESPVSRKWSVKSDSGASSLGGCSTGNDGCRKLPERMGLPMEWFGQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5W1</accession>
    <name>A0ABR3C5W1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616832.1">
        <property type="nucleotide sequence ID" value="XM_066754931.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987218"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="701"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1107"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1119"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1184"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1303" mass="145823" checksum="5B1C0CEC1B7D6019" modified="2025-10-08" version="1">MSTMTIDIHETTIVSESRLPIRLDRQQTTPSSQTALSFQPLMNIGREMECKQNNRSRKIPRVESKSDQKAAGPIAETNNAYQLGIKDGVPANRSEPTTEREALDEMRNQGTCPHLEDIQPARCNAEKSLLEFSSLKSARAIPPSRHQLHPSLVMTPQNENTSKAVFPLATNRMLNSGKNIHLNPLKHLGPRSRIKNGENIDPTSATKPGSACIIDHASSPQPCIGSQEPSYPISSIQTITGVSAPLAWTGEKNETRAKQISGRDKHEAPVMESPSASVSLLNASVTDESMSVAFENFKAPGTGGVNQIKSRESSRRDWWRRDPHPMFSPKYAAQRLLIEFPSSINVNHAKPILESHFCKYGKIHSVYHYDQNGDRCSKGFVVFIDPMSIQKVLTDPHNNICANSLDPEAPRDMAITIRPSSASDLERTVFICVTGYQSAEEAREPHHEYQLTLEQEIKAKHILSQDQNSFSMTHDMRGMIKSDELLPFHKTLLPEKVILDQVPMKGKTPGKYYSTVCVRNLNTPWFDFVRQVRERCGRDPVQIGEIALRGPNVCERNFVPQLCDHLAEICSIRPPNEKYCGWLVSVSGSRDGRRMMHELQKIPGFFVRWADEGDGLFDDAEPALEKSPLNCTCSFEEHPFPTETDDAGSLSTSQTNNHVFSTWLRPSPTHPHLRRTLLHTYRGRPLIEDNSTGETKFLDESAIFVGRLNKRMETYATLYKRFEKYGKICYMEFNPKAVPSHVNNATARIMYQDQESAAKAIARENGSTSFGSAIRVELRKVIHSDVHTRRVYVDATGRIIRPSTVAKLVPESGVRRVTGSQSAIEARMQQPPFPPGLNMPSETYFPVSSLQPGFSQSDVGINMPMATFPPHFSVSPPALSARDGLQHLAILGVQGHLSPTYDHILPLSSGMTTTDQPFYPAPKAFQSPQSLTGQSSSIAYSPARDAHFQRPHDEQFFAGQPHPNPAPIHYPLFTLDEPSFPRPEVSNYPEVSTIAPIDDEGNVSNTRLKPIAYKEENGTVKAIYDDNELKAYCLQNNLPYPPEPEKKTKKASDGGFIATQDWRKSLLPVQTGGHDPSIPSPLRKGSVAFAEAQKPSLLSRLRLRRSQSDYSLSTNGKPQDYRQDFDERSSVISASTTSRYEENSYSSSPRLARWHLLNYDSPPGHHNQPIQAQVNNTDDHLKQPSRNLPSRQPLSPPNVSLHFDPEFLEEHMFHLDIHGQVSLPLYLPPPLVQGSQSWYPTSFGASGQQLHNQQQMTGYIQSDGNSWMVNESPIVPGPKYERVRFRGRGRGPGWRRKTFSAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5Y3</accession>
    <name>A0ABR3C5Y3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617319.1">
        <property type="nucleotide sequence ID" value="XM_066755418.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987713"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <begin position="169"/>
            <end position="191"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="211"/>
            <end position="229"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="171"/>
            <end position="621"/>
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        </source>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="PROSITE" id="PS50850"/>
        </source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="645" mass="70957" checksum="0A3F66183C0E9852" modified="2025-10-08" version="1">MPSALLAEKRPPSTSPPVPDFTACPPPSTICQDQIQKQSAAADPIIPATSSAVPQTSPDFVLQWEYECNEKVDLTDEGKGLHNDHYASSTKTIGEKTPPELQNSTLPPGCTWGPELTPELLSALKLDPSHYPPTTCSVEASETVPRIIWVSFPPNSPHNPFFFSRGRKLGITAVATCFTLLTSVNVSAYSIGEISMCRDLGISTETAAVGLGIYCFGFAITPMILAPLSEEFGRRWTYVAAVFIFLVFHIMMAAAKNLATMLIARILQGCAGSVGSTLVGGTIADIYIPVQRGLPSAVFALAGVSGSGIGPVIYAWVESTPRLEWRWIWWIQSITIGALFPFILLIMCETRESVILRRRAAKLRKEHQSGGTNGEGDHDLLQTPNEIRGRFTAWSEMNRIGFWEAMRTSALRPFTFLVVEPVVAFIALWVSIAWGVLYIQIGGLPYVFRNIYAFSTNQVGLVYLSLVIGALIGFLANFAQDAIYRRRVHLDGVEARLYAPMVAGITFAVGCFLFGFTSLPNIYWLVPCIGIVIAIASCLTIYISAFVYLSECYGSYASSAVAAQSFLRNAFGGAFSMFTVKMYIAITPRWTIFTWGVVALILAWVPFIAFYKGTIIRAHSKYSKILMREERERIEREKEILDGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C677</accession>
    <name>A0ABR3C677_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="116"/>
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    </feature>
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        </source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="446" mass="50076" checksum="7B34A78680583983" modified="2025-10-08" version="1">MSSPLFTRTSNSFTSGSSDCLLEPLLTPIPLLHTQTAATGPSRPKLDRLNTATPLLPRIKGSLYGDFWRGHWHLPWRGHRSAKDSTHRCGHARLRSCVWLVWKITLAVVIGIFLYWCGWQDARDQRLTLFDQLEELPISINTTISTKGVTKIWANSHNDEMQGKHALILALKQGFGYIEIDTHLDASSSADSSLSLLAGHEVSDLNSNRTVKDLYLDPLLAILDAHNRDWTAGNEKNWTGVYEDDPREEVTLFFDIKSDGDATWPYLEAALEPFLSKGYLTTYNTTSNELIPGPLTIVGTGNTPLHRVYYSPSRYIFYDAPLLELYHPHTLPASQYGPETTIHWNPTISPIASAKFPLQSYLALGPGSRGGGFNPFSCNLKLTSAIAREMGIQARWWGILHKPGWVRRMLWETVWESGAGVMNADDLEDMGNWLRGREGKERSLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6I5</accession>
    <name>A0ABR3C6I5_9TREE</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_066755322.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987615"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN CBG12783"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="12"/>
            <end position="30"/>
        </location>
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        <location>
            <begin position="2340"/>
            <end position="2361"/>
        </location>
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            <end position="51"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <end position="620"/>
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    </feature>
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            <begin position="642"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1985"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2057"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2081"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2132"/>
            <end position="2145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2148"/>
            <end position="2161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2174"/>
            <end position="2215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="2631" mass="294421" checksum="7BF0947A9056B529" modified="2025-10-08" version="1">MTDPDTAAREAITIVSVLALFLIASIFIFVTGGRRKKSQSDVPDNGSSQIPLDSPGDNGINEEQRRRRKKPGKKKRDGKRKKKDNERWRDRNEGGTKSDGGSSDAGDDGSDDGSDHGRRRGSSTTPPGFSDLSSADTIGGGGLDNPPHGPPDIRAGTMENVFRIADDLTLTVQSNLDDRYRIRTIYQGDSDDSALEGGSWPRRSDGPEGGAGAIRIPQSSEILPPFTLGVPATPLTPGSLPALNLLPITPGPLTQSQHSPSIPATPVSAYPPVTATLEHANPILFSDVFEDGLDPWAYTSAAPTKTTFTAEDLGWYNQRKETTKPMALSDVFDVPVLDEALGSPELDTINKHAPRMLGHLDRNHTHTRNAGDGAAGSPRIETSGAWGELSPIDLNPIYVRDPKDRDNDSTPILLSSLKTPNAIDKVRQKAVHQEQKVEANDKKRTEVITPHSAIKMPMTSKLRFGEVSSGPITSAGIEEVDRARLKKKNDSDMKVKIKNVKKKETASEPQQEVEKKKKCGTPKKALAIFEDDDIVKDEKPKGKLKEKEEIKKTAEKKEENPKKGKKLKEMEILVEDPETNEIVKKKSLKETEESEDEKMKTETSSKKDRAKNDNRTEHKVPKANTRKEKKKIENREQLNGSETEEEEEVEGEQGKKGDNDRKDKKQKNKLKKKKTTKDENEEAAEGGKKKREKKRKEKVGTDEDDEIDEEEGEEEQEGGKKVKKAIKLKKKANAASVEEDEKDMTSRKKGAKKKSMKRRDDAEDQVQNESSDQAVYEKYTDSDGEKRLRRVPIVAERRIKRKPKKNKQRMADASQYNRYNDDEEEMDEVQETAPAKLRKAPKQQQQSQIMRQGRTLQDEHFLEDRAPINFTMPDRINQLQSPRHQHRYKELQSRIGNIENDYDDPNLTTKERHDIANRRLRMLFNQRATEKETEELQRLMAEGSQRNVEDSAGVARERKSLRETIKGKFAETVEAKREDLQTDGPNIRLSTGHEEIALEDNVGTTAEVRQPTKPQRKRTLQSQDATVLEPTSTNADNHKTYVSPSTVATEGLWAGDSQEKPKEREIDPRLNLMAFRRPGQMADPRQLVQTPRALAPSARSMKEMEANRLYLRQKRHPTEEETGAEYDAKKDQGPFVSSVFALSHSVTGISMKTDATDGAELSLTLTGEVGPHVASSPNHENPAEAAGLAAMRDNDRLQEIRPLAFGPEQESDESQSMTDSRCISDTTKFEAAESRSDQLLALNNMHRRPSEDVRQEKDALKDDDHLAQLTTAGRFTELQSPSANSDNQIITNSHAIARLPTPLMVASNELQNISDNRPPVDHYEPMDQEMEIHQQTDYLPVDMVKGTDEGMFTKSGTTIEGWRKPMAIVDSASSCEKESGQAIGTELIPSNSASRERCRERRKQALDSDPIIPIIRSGTTTAASEAIISLTARQQAPPIGNREAQMDFQPSSDNARQIPNVDRNRPVLDLTNLSEEQIAEYELTGNLPPTLQADYDLEEHSDDESATKTVQSGVKSGRRGQTALNYMLQDDEEKKTESQIATHNRAPSQSIPERPELGSVPFHNPQTMEERSFQLVSSKGALPERGREPQKPASSLGQYEPDREEEAGVDGNALVRSNDILGGRGRPQLDFNPSEDLERIQEAGTDLITAKGERRRPEGFDNPCSFDSVSYKDHQAQAHVDLSLLSETDKYDEVDVEPPINEGRQRLLRETAYYSDESRHEESGKRATEATKVNVKPLQCRQDVIESDREVADTDILREAIPRSREKLTDSISPDEGNVTVPRRRTVPTRIVTSAPTDSDGESIPLLSGSTAINSSDEEELASQTAHQRANIKNMEADQTVAIKNAVADNPELAREYQEAKLRQPKGIDTGINQRNGHARRRQNKGVNGSDTDAEDFDRVRPQNRPPMREWALGYESDSTNDTASIHIDSDEDTNAPASQQISRCPPSQLSPRRRPSQAQEPSSPDSLKPRIETFPSENEDEGSMESRNRTPAEIVRDHWRNQSDRERQQRANEGEAHKPPSQDAGNYQQSDDERAPANSQSQEKTADSAGRPPTRRQSEGDISPKKEDDPVSPLSPDSKNIVDQRRAKQQEREIISDDDSSDVSHEHGVEGQQRVATPLEKPYRPEDDLPSSKTQPEGSQQMDQNRNKHRRFGHENRRGRKENSDEEIIPKMSKKELRKQRLEENVKSREAAEGKENGIGEIKDGEIKDKGEKSKVKKRKQGDDLRSQDAGGVYGKVTGNDEKNGISKSLYYSRVALGPVDLVKASWHILKTAPVWSFFTAAALAIYIEASRQLFEMLSVAARTTVLTKRATSNSIPVDLSITQSWFSDLVKNLSFDPIAFFAFISMWSIICIPIMGILIHNTLSVAAEPKRTSYWKQMWRNFKEYGQGSLQVLIMGRHFSAPRVFWRRSTRWTYLRILIFSIQLAGIVLIIRQAMSLIYMVGTGSSTSFSNLPDVASSQKAIKEAAESLDAEGVFVILNFLFFLFLLTIAGSWHALLHPRTGSLSRKSPSKTADKKSDNGRQGQFYLPGVRTALKWLFILVIIVAFTASLLYFRNIASYIAQQSGDKANSDVVILGVNFIFMILMAAMGYVVHELDKIWIGRLKGKYWGKSGKGFRLLDCRRGKDESMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHK7</accession>
    <name>A0ABR3BHK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610699.1">
        <property type="nucleotide sequence ID" value="XM_066761159.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993592"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31309" checksum="8D0541DA29B5AF28" modified="2025-10-08" version="1">MPTFHTRARHILTNCRPLLLSFGFTAVLPLRSLALFSTTAGKAAEAKCTRYLYRKPGPMAMRESPWPVIFLRAKGLGVEEEGEWADWSGMFAERGYTSIEIDITAPSPQSLPSGESPFRQMTTALSSQVRLSAVPFPPIIFARGISTLLAQAFIEDFPASGLVLVDPLPDEDPRAVGQGREKENGGGLADWVVGGNKGGWEWPKFKYEPHFPILLITSQTRMTALSTSNRLVRDHVRENPNRHGWLGGRSGKGLELVVTDGLENGGLSEGSRLEVERWMDRSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI00</accession>
    <name>A0ABR3BI00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610834.1">
        <property type="nucleotide sequence ID" value="XM_066761009.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993440"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047290222" description="Glycoside hydrolase family 5 domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="93"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="373" mass="42008" checksum="32EEC7F22FA864AD" modified="2025-10-08" version="1">MVKLSPCAFLISQFLISTITLPVRTLVLGNHDSIFNKRTTLAPGFTWGTDPMRGVNIGGWLVLEPWITPSIFEGKPDWVIDEWTYGVYMNNRTDTIELENIAAVGLNTIRIQIAFWSVIPLENGEPYLVGAYDYLKLAVTWASSLNLKVMVDVHGCPGGQNGFDNSGIRGVREWSTNDTNIPRTLSTIQALTAEFSQWFYNDTVIAIELINEPFPYSTAELDILKSYYEAGYGTHIYTMFDTGLITMGYSESLDWYCGQKDYLVTSNNVHWTIVGEFAPANTDCAYWLNGRGMGARYDNTLNTSASLRYPGDCGGKTGADPRKFSAEYVEYLAKSFETQTWVYEQASGWVMWTWKTEQAADWSMQTGITYGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI33</accession>
    <name>A0ABR3BI33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610867.1">
        <property type="nucleotide sequence ID" value="XM_066761042.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993474"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="139" mass="15534" checksum="4E45A3C2751106AF" modified="2025-10-08" version="1">MSRTVDIPQDVLDALKQFRFKNSKGTSAISVKIIKNSLTMAVDEEFEGQSIEEIAEELPENAPRYVLLSHQLKHKDGRISYPLLLINWAPSTSSIELMTLHASSLSYFQQVSETAKVLEVRDGAEGLTTESVNEKLLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI68</accession>
    <name>A0ABR3BI68_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610895.1">
        <property type="nucleotide sequence ID" value="XM_066761070.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993502"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="125" mass="13406" checksum="51D76116BA8D24FC" modified="2025-10-08" version="1">MSVPLNISHNIHTQTPITKETAPSGTNVKLNSVSCITLEQPQKDLDGNKSDYAQAKTESKNVEGGQCLGDDALSTGSRHDSGVHHDSVKQTRAQDAHAALKPDISLAKTNVFPKVLPSHNRQGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI87</accession>
    <name>A0ABR3BI87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">60S ribosomal protein L41</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_106660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610907.1">
        <property type="nucleotide sequence ID" value="XM_066761082.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993515"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0240408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="164" mass="18927" checksum="F09BBD23CDD10187" modified="2025-10-08" version="1">MGNFFFGKRRNRHYKATFSEFRSALSNEGVWWPRPTETSLLNSSTTFFIPQEYCSAVKMVNIPKTRRTYCKGKACKKHTPHKVTQYKKGKDSLSAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECTVCKTKHQLALKRCKHFELGGDKKQRGAAISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI90</accession>
    <name>A0ABR3BI90_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610912.1">
        <property type="nucleotide sequence ID" value="XM_066761087.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993520"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="321" mass="35748" checksum="CC8D2514475CBCC3" modified="2025-10-08" version="1">MAPVIPIHEAPLPPPPIKKFYLSTPDSIQPTSPHSFPHSIPETSLLLSLSHPDLSTSPATAFFLSCLPDPILFLHYAAAFIHPRLTLGNGGGWRHQLVELVLEDKDGLAATSGGRIGVSLNWVGNIMDDVRKGQKRVEMAVKEFKGVLLHEMVHTIQHDGQGTTPGWLIESIADVCRLYAGLDPPHWRKPGQGKKEKGWKDGYDAGARFLAWLIENDRGIGDGNGVNNGRQEHFIIPPQSSTSTFAPPAHATKYPSSSETYQQTFHPVPPTKARLGPFPDLLRLIDSRLIYEKWNDSWWEEMTGHKLDKLWAAYLSYYGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIA6</accession>
    <name>A0ABR3BIA6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="6" type="ORF">I308_106675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610922.1">
        <property type="nucleotide sequence ID" value="XM_066761097.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993530"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="440" mass="47826" checksum="32D49D41C8205ED1" modified="2025-10-08" version="1">MPELQSLGSLPAHAEPAWTVTFNPARSLLASCSTDRTIRLYSYILPSSSDGSPSKDDPQPVFSLAKVIETEHKRTVRSIAWSPDGRTLASGSFDSTVGVWEEVIPLSDDEDEGDEGAQGVYKPAGMNSGGDVDEGKEKEWECVSTLEGHESECKSVGFSSDGALLASCSRDKSVWVWEVQPDADFECIAVMMEHSQDVKSVAWHPHEEILASASYDSYIHLAYDDPDSDWCIFQKLHPSLPSTPLTIPSTSPSHLIDALVPTEEEKKAEAELQVPPLEEHETVWCLAWSPDGRWLASGGDNGGIRLWRRTGTQPDSAFKEILHTAAHSRSVFSLSWSAPYPSAESTSSTDSTDLGMLASAGEDGKIIIWQLTVPPSSSPSSKETDNEQISIKPIAAQKHAHGVNDVNSVAWCMRGDKKGWGMLSSAGDDGSVKVWRVVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIH2</accession>
    <name>A0ABR3BIH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610992.1">
        <property type="nucleotide sequence ID" value="XM_066760720.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993142"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="232" mass="25025" checksum="5517DC844ECEE2B1" modified="2025-10-08" version="1">MPYVPPGSDKPQPIPLTQVKERQAAATITTEQHTQPEPFLSITATPTDDIPTPKASASLSPEQPNPAMASPMSVPQPITSPEDMLASQLAATSLDSSTSSPPSLSHSVGHPSPSPSSVLSLSEQSSEDLSDEHVKVAGEMVGKIDDQDVTVHVQEAPKVMTPDVRMQELEKDPVSLYSEAIYAYTHKLYVRAQRSVTRAEKKKDLVYPQFGSKPTGMEKMAKKKAIARQLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIZ7</accession>
    <name>A0ABR3BIZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_106464</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611164.1">
        <property type="nucleotide sequence ID" value="XM_066760892.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993319"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="192"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0240665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="545" mass="58982" checksum="CA41ACA3852A001D" modified="2025-10-08" version="1">MSLPFLSRDALVSMSGSASDKMADTRPPIQHSVATSYSSSNSHHSPRISSSLGTTSCLNSHFHNPTHPPEPEGQWSPTPLLATQSPLALRRGRGMTFEEARREGIISPHERSVTPVLSQPCALARALSRGDLEEELASPKATRRDSYWRVNGERGANGDRDGNGNPGEGTPLLGDAKAERREKLARLALNINTIVNVLLVGGKATAVLYSSSISLVASLVDSALDLLSTFIILGTSLAIGMKTDAHKYPAGKRRFEPLGVLIFSVAMIASFVQVFIESFKRTIGPPEDRPIDLGPLGVGIMLATIGIKGTLWVWCSRIPSSGVQALAQDAENDVFFNTMSLAFPWIGSLLSWRLLDPIGGMILSAYIIVEWIKTLLENFANLSGKTASADQISRVLYLVSRFNPVLEIADIECYHIGDDLIVEVDVILPKTSSLHYAHDVGETIQCVIESLDGVIRAYVHCDYSSFNPLQHTARTPQPYPITRFQSTGGSSSDSGSGTLTPRPIHYLTSNTLDLNGINDRTATTSSRSFSEERIRDKGDGDAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ16</accession>
    <name>A0ABR3BJ16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTPase activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611156.1">
        <property type="nucleotide sequence ID" value="XM_066760884.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993311"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1017" mass="110137" checksum="8969DC2F002446E3" modified="2025-10-08" version="1">MSPVPLPPAGTLVPSDDWTDDPSFDFNISGSNFTLPSSPSPSSTSSHRSSLSHSLTSSPLRQIHTPASKDGGLKLKPEKGIESFDDDFHLPTGDLPPLPSPRDKPQRARSSAASSPSPGCHITRTVVGTGPKGAGTIVKLGGSRESRSVPSSGVLAEAVDARARALERSWEADIGVDDFEKAFGEEEDKSATLKLKGGLPDLEGKRLFLSEKEFAGADVLIDFMDLDDEDQATLKAGATIKALLPPPRTRKYEPATLEDGLEADFALPLNLTNLTLATQPASRYRRTGPRDSIASAVNSESWGSPSTSRFSETSATSISDGLAENNAKEKDELYAEENLEDGLEFEPTFFAASRAKELNSILDRKRRPEYAPAPSPRRDTQRTAGDSFEDGLILDDPVVELSRHRLRVQKRARDRHPPTLHKGQPQKNVVKERGKAWEKQREQGWGRNTPVPPPHGSIRERTQSGIGGFGGLGLLGLALRSHSVSTVVRDSSRPSGVGVSGREKEAMRSRSGHLLDIAPPPIPMSSTPSQPPTPSASRLRHQKSHFHLAVPSRSPSLTRKQSLASLQDAMAQRIESGSGIGSQFEQLGLPPGSSSNHSSIGAKDRDRYHNSPSRLTMPTSSSRAKVRPPVSSIFPKADLTTSTTFTATSTQNPFPPHSTMSMGSRLTPASNFATSSSPAYAMMMKMNSSRRKLYGDGTELDGIDDLRIDEDLSNWAIGKGQESGSIGSLAELGLGKPSMREHEHRLHSHGQNQGHSQTQAAGQKDKPQEEKRKKSGGTQLATRKIRRKGGGLIKHLGGADKKKVVGEMTWNPNTLRWEGNESILRDFDTISSTRPALITHYTGSSVGAGVYSSIGSTSAAVAPRIVGDMQFDPIHMKWISVLPADEDEPDPFEGMADDEDEEAGGGTIRAGAGRRFVPIGPGSGSVASSSTWSQRLASESSMSVAASSASWEDRTRPSIGVEISPELWAECKEAEERHRKEMRGWIMPPPNGSSEMRDRERREERRLWEIRSLAMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ73</accession>
    <name>A0ABR3BJ73_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uracil transporter FurD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611216.1">
        <property type="nucleotide sequence ID" value="XM_066760455.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992861"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0241834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="61598" checksum="481382097142B01E" modified="2025-10-08" version="1">MTVTQTIRNRLTRPSAWVLPKEESCIAPEEVWSNKDMDPAPLEHRRWTSWTFFAYWISDLITPGGWATSSSFVEMGLTWWESCLAMYVGGFLVAIVITANGIIGAKLHTPFAITSRSVYGYWGSKFVVFSRMACACFWLSINSWSGGVFISLMIKAIWPQYANLKNTIPASQGATSADFLSFFLFWLLQFPFIFIHPSKLKWVFNAKAFLVVIVAVGTMIWALVKAGSHAGEALGSPANRAAGGIPRFKAFMYAVTASQSTWATLSVNIGDFSRYCKKPSASYIQLLVFPILYAGLSFFASITASCASYVYGSENSYYQPYDIVALWNTSAGGRCAMFLASFVWALCNVTTNITANSISAANDMTSLAPKYINIQRGQLIAVTIGVWGFVPWKVLATASNFLTFMASYSIVLAPIAVIMVTDFFLVKKQKVDIYELYKPHGIYRFSKGWNWRAYIALAVAVAPNLPGMVNAINSSIDIGNIKYVYMVSNIIGNTIALTVYLVLNYVFPATESHVSVPIHDLINPEEDYGPAYGIYQSTLKNSEKDAETDAEVKSALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ96</accession>
    <name>A0ABR3BJ96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_106037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611247.1">
        <property type="nucleotide sequence ID" value="XM_066760486.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992892"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PINIT" evidence="11">
        <location>
            <begin position="177"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="10">
        <location>
            <begin position="398"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="515"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="760"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="795"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="815"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0241865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="826" mass="88498" checksum="39842487CFA7D7FC" modified="2025-10-08" version="1">MDMMLRHTGTFRAPARKTDWSGFEEFLRSWIPSHTVPQLRSFASALVTYGRREPFVRSGDRKADVIQKIQEAFMALKAGMDLDAYVEARYHCEVAVGGGWDPFPRTSTTTLVPPVPPVRTHPPVQPPPPPTFGGVPRWSSGAASVNSSGPGLNGYRSTSGSASSSVAYGNTSAHASSSTSTHGPQHVLQDWKINPMWKPLRAITSMETLPDISANESHSTYRAKRTQFVLPNDVIEKLKVSRESPKTPPHYSLRLFCTSSDHYRPTSVYARHLPPSTNIPIEYPGNPEVSIDGTVLPFKEKGLRGKAGSAPPFDLDKPIDSGVTVGGRVALVPGRLMSVNIGHRGPTTGKNKNQSKRFFFQIVVAEMTTKEELLAKLDKLEPTKAEDAIEQLRRKQEEDDDIVAGTASMSLKDPLSYMRMTRPIRSSKCGHIQCFDATWWIESNAVHPQWLCPHCSKELRFDDLIVDGYVMDILKAVPDTVDDVILEPTGEWHTEDNKYGTASWLASHVKSSSATAASTPVAPSAPASCSSEIETKPSVNDMNGTSGGDGANRGVAGLKRKVVQVIDSDDERDGTPAKSSVPPAGRVAALGSSSSVNGSRTGASTPIIDLTLSDSDDETDEESGPATSSRVPPAPIQVPRTSTAAGAIVSPKRPVSAAGTHFHSLRETTSDRLRSPSASSWHGRSTTGIGDVGGRSSPLNHINGQASTSASGSAITSHLQPPSDQYPSISPSHFTDPPPQTTLESPRIAALPPSSHIFPSFPPSPASTAPAAPPPHVLPTRPFSRPGWVNPLAPSSSSEISSSTYASTTSPSDNRGSERESSGSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJB1</accession>
    <name>A0ABR3BJB1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611269.1">
        <property type="nucleotide sequence ID" value="XM_066760508.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992916"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0241887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="421" mass="46780" checksum="EB610614B38B981F" modified="2025-10-08" version="1">MSAFDRLGSIASRGHDIARKSSHFRFYCLHTSGGWLASVMLPLTDFTGIWEFVFASVLFVVAWTILRMEQVEISLLHGFIFDLTIPLQYHVHQTLSKAHAQHLEHYWPLFIFGTMIEFVTFFLVHPDLFTLVVCLKTTILLGIWLGRDDRGGFLTIKLRGKGILPEDIGMQPVIGINSKEKKEISNGYGTVREAKPAQENSNEGKKKKRKGNESKNGKQEKPKTMSNYKKDKLDKETFKPNSRSEKGKKYDKEGKEKRTEKEKNPSSKSSESFSTTPSSASSILSPSSPTDNSGTNSQISSTPFSETTNDASEAPSTLSSASSTASTPGLQESETAAPSLRPDSPELSTVSSRRDGTPKLEERNAVNEIKTKGREGGDMKSGRNRYDSKGFKGNLMPIRKEIYTGPRGDWQGSESQKNKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJM5</accession>
    <name>A0ABR3BJM5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein transporter SEC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_106167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611375.1">
        <property type="nucleotide sequence ID" value="XM_066760614.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993022"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="5">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="6">
        <location>
            <begin position="393"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="8">
        <location>
            <begin position="637"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="7">
        <location>
            <begin position="732"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0241993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111356" checksum="7924A8B9B636B3FA" modified="2025-10-08" version="1">MAPRTRYAIDPSLTGHPAAPPSQQQQWQQPEYIQAAQPGYQPETYRQQAHSDPNSMPQLHNVPERELRPSGAYAPVQSNHRATHPSQQLQQKQQQHEMQSPRATPPPNHIPQPPHSSGPIMSGMRVRIDPSQVPNPIEAQELDQNLYEDEDFLSCQTRGLIPLVGTDYRGVDQGNSLPRHLRATLPCVPSNGQLLDTTALPFGVLVQPFAPLRYDEAPIPCISSWVSGQSAFDPPAFKGETWGAEGEGDEQGPPRCEKCRGYINPWIRFVDGGRRWTCNLCGSPNEVSSQYFCHLAPNGQRLDHAERPELQFGTVDFPVPPSYWALQPASGSLLDSIDSDALASTAHDLLGGLQASLGQNQPHIPTGKEQREKEKEKEKERKKFRKPVALSRVFILDVSAHAGESGVARQVCEGIRKAIYGSKGSEDEEEELLGEGQRVGFVSVGESVSFWNLSSHLQAPSQAVVSDLDDMFIPFTAGFLVDPHESRAQIEHLLELLPNLAEQGREGGRVAAGSAVVGALAGLNRIGGQINLFLTSLTTHGLGTLKTRENPDYYNTDKERTLFTPSEWYLTTADQLAEAGVGVNLFLFPSAYTDIASLGALAAGTGGETFFHPRFDVDRDREKVHSELRQVLTRETAYNATVRVRCSNGLRVSDHLGNFYQRSLTDLEYATIDSAKSFTAVLKHEHRLDDRQPAFIQVAVLYTSKEGERRVRCLNMSFVVTSMIGNVFKFADQEACVSVLFKAGLSQVTQRSLRDIRKSLTDRANRVLLMYRKHCAPAVQHGQLILPEGFKLLPLYTLCMTKSKPIKGGSVSSDVRMHYTRHIKSLSPTRVLILLYPRLLAIHDLAPTAGFADSNTGRLILPRFMRNSHSWMVAEGAYLMINGEIAMLWLGQAVNPQIINDLYGVDNLEDLDIRITRLPNLPTLLSTQIRNILTHLSSPHLIDQELPVVIVRQNMDGAEVEFANQLVEDSNNDALSYTDFLMTAHREITNDLSGGKGDSWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJW7</accession>
    <name>A0ABR3BJW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Rad50/SbcC-type AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_106397</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611098.1">
        <property type="nucleotide sequence ID" value="XM_066760826.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993252"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004584">
        <property type="entry name" value="Rad50_eukaryotes"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00606">
        <property type="entry name" value="rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="15">
        <location>
            <begin position="30"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="230"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="341"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="627"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="796"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="926"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0240599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1353" mass="155130" checksum="512F2A13A78CC19D" modified="2025-10-08" version="1">MDSTFLTVYPSEAWLPRLGRKTVAMASLNKLAIRGIRSFDDKHVQVIEFYSPLTVIVGHNGSGKTTIIECLKYATTGDMPPNTKGGAFVHDPKMAGEKEVKAQVRLRFWNAKRERMTATRNLQVTTKKTGQLTMKTLEGILAKTDVGDGNGKRNTISTKCSEMDEEVPYLLGVSRAILENVIFCHQEESNWPLSEPAALKKKFDDIFEATKYTKALDNIKALRKERMAELKVDKERLKFLKADKDKAERLRKDLEESISQENRKQAELDNLKERYETIKIRNAEFYEEATLFRQIYEQSKSLKEKKKMYEDNRKHSKLNMQEMNESTEELLHMQQNFDAHLETLKMQLEEKEDAKEMKESLLEELRADERNLINTQGGLVAHRQAYERNLREREAAIRQIAKTHDLVGYDYSPLEDSKVAEFVNKIYEMVRKAENDLKKLQAENNRKERELQDELDRLSTMKASAQATRKSKEDQIIKLTEKIRTSEATFHSISNPSFELEINQNKLTELEADLAKFQSEIADAKYDEKINQRGLLIRQKELERDSISAELAVLNRKADSRAKLDLQRNELEGKNSQITTLLKTHEAKFRELVEADIHDLKPVDLEDKVIGAISHKDRDLMQEENSASALNRDHSQVQASLNRAREELTIKKREVQSMQREIEAAIYNVNQPAEGEEVPAEEAKNLAEAFDICRSEIETVQRAIMDKQGSRVVWEGLLTTVKAGGVCEACNRGIKHEEKNAVTRHMEAKIRQLMEAEQAGVDAEIEVEKSWTEILDTLIRVEPHEAKIQDLQRRVIPRLETQIKEGEEKLRSLVKEVDDSKASIQKLKSASRDLQNLKSTASYINHLYLEISDLKANVKRLQTELESSGSSKTVEEVQKDVDRVTQVIKTLSREQQDFSSEKELKVNALRAIQDEIGRKSLHIGRLKAQQDKRKMEEEALNDMQNTLGALRNELRDLDQTVQTAEAPWKEKNEALGRFRTERANTEKEASTQVRMYQSSLGEIEGKHKACQVYVAEGNDRKIQENEIAMSDIKRQISHSNDARAALEAEIFALSSELSRSESLKANIRSNLKYREDGKKIEMVQAELNELDLDSAAESRAKFNKEYKGMLDEETEAQGLMAITQGGLLEMRANRQKMEKTLKMDYKNIDKEHKEQLIKTTISEYANNDLEKYAKALDNAILKYHSIKMDEINDTIGHLWNKTYQGTDIDGIRIVSDHDEASTSTRKSYNYRVVMVKNEVELDMRGRCSAGQKVLASIIIRLALAESFGQGCGVLALDEPTTNLDQENINALAESLAEIIRERRQQANFQLIVITHDEGFLQRLAEQDVVEYYWRVSRDASQKSVLERQRVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKB6</accession>
    <name>A0ABR3BKB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,3-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611431.1">
        <property type="nucleotide sequence ID" value="XM_066760670.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993092"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF5">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE CMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="72281" checksum="2E92C223A84E1D5B" modified="2025-10-08" version="1">MAPDIPKRNGPLPQYISSHRAPHIRTPLSSASFFNTNFKAAGRNMSNSRLRVSLSKPIVRVLLVGSVLIGLVLLSRLGGGKDDGAWDASSWSDRHTGGRLVSPGSRRGWPLWGDPSKLHTDQALPRPILTRQNDTLPRPTHPGKSRRIKPDSDPDNPEYIEGPLPTLDEAWEFLHPLLQEIKSRTPSVPREHELTEPIFPPFLRDDLKERYRHLRDVFDDNTGQWVRGPERRWYLVTVCRQVAGMLADWFAAWTVLADFLGPESLVFSLLEGDSADGSGEILAHAMRAHLLNIGVPPSNIHIRTQLPPLDWDNHHRIELLAQMRNFGMQPFYDTAATGLSPDGHPWTGIVFYNDVYLSATHFLELMHQHFEQDADMTCGWDHAGRWFYDGWVARDMSGDLFTPFPVKEEDKDLPQKLFPSSPETLRRFKRILPFQAFAAWNGIAVMTPEPFLPPYNVRFRRGTPRTEDFWECQASESSFISWDFWKYGFGRIAVVPGVHATYGKEDAMVRGWVEWPSEEDQHDENIRWNPNPPHKIRCHDWPDGLGKGYWAWDTVRWVKPPKLEIPSASETIFAQSWNFGKCIYVLLLLLRLFSLVDKDAKNIDRNVLSESDIVNAASSSKLPQEKESEPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKH1</accession>
    <name>A0ABR3BKH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611663.1">
        <property type="nucleotide sequence ID" value="XM_066760359.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992765"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10212" checksum="2F3AAB0A253F0420" modified="2025-10-08" version="1">MSAPLQQSNAQNTVPPSAPQPSFLQKKGLLGAAGRGGVKPGSIVSPSDVLSPISAKLNSSKQRHFQKGKPIHLASQLSQLASQASPASKENKPKIDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKK4</accession>
    <name>A0ABR3BKK4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_106115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611323.1">
        <property type="nucleotide sequence ID" value="XM_066760562.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992970"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF139">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="721"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="823"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="847"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="116"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="357"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="565"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="895"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1086"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1206"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1297"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="895"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="911"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1267"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1297"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1366"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0241941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1386" mass="156233" checksum="839A22F2BF612DD4" modified="2025-10-08" version="1">MADLSQHANYTAAYSGLLDNFYLTVAIAGACFLGHEIEVHIPRQRGRDGPRQRLAVRAYNALARQWNRRKDPGASLQSRRRKGSWRLSSEGLVGGDKPVDPERERLGSRESWEFGYIFQPKAWAVNASRPLPKWPLAWIGTALKFRERDMPAKCGLDLTLHARFLRGCFFYTLLQTLIVMPILMPLHIFYSPTDIASTSMLRASVSSLVQSSGSRWLWVHALLIWWVSITWTCTVLWITWGGLAYRRREIKALAIKVQKERASKRVASGGEEGMDGMALPEDYEGIKRFRTVMVLNIPPDMRDENILQDYFDYYIEKHHQRKQDPSKRKPLTKRFKHAIPIGQNPSYPVDVEPAEKSSVEDVVLVRKLGVLINLRSRREEVLKRLEIAHTELAKRVLADVAKYYKRPKALYAIKDPAKAARMSILVEKLGRFTEPKSPHGDQTVWDALHSVPREYLDPYQALTHSKPLSILRHHNPPLIDYLTAKLSYLTHLLTESLSKPLESYSTASTAFVTFRDAKTARLVLKILDSHPKRSLACKTVAAPDWTDLLWPRLGKSVYRSEFVRGWVVYLGVWVFTLAWIFPVSLLCALASLTNIAGFIKPLQAFLSNNPKAASALTSLAPVILVALLTLAICPILLVIANKAETIMTRLGVHNSVLERFWKFLMVNGVVFFAIGQSAIEAYLTAFQSKNFDPLPIVASAFPTAAPYFASYILLQVAIQPCFEVFRFGLATIVYVFGTRRSVIPRQRRSRTEYPTFSHFSQLPQQLLAGAIMHLFMLLNPLVIAFTLVFYGACYVVWKRQFIYVYGRLYEVNGRRSCIRIQRYSMDALALAQFVLFAFFILNEAKGHAIATGVLFVLTLITKIIITRALKKRFNKLDYEEADILCPPVSATATAVKQGEGDNTTIHYSSDSSDEEDEDLDDEESTRQGGNCKTIRRNFGSWTRSRGRHHRPISFRKFIPFDRTIFSSLDSRIQFDPTPTTETPLDDYLDPSTTLPPSPNLDELSIVVPHPPLPPWEDIPPYQRSRGYNDQPAYTDGFEQFLLLQRDPRSTIDLDDCVEMRLALTSSHGGTGVMGDWSLGIEKDNEGFDAEEDKGEGRPPTFRSKTEPVLPTILDSKTDLPSIRSEIWNEGGANLHRRHTEKTNSNLANVFQAPPSRAAERDGAISMQTFSVSSAGALPLDSPEILTAGHEGSLSTLSPRSIPSIFRRRSFHGSNDETDTTVSPRPRPDSHISFGSLGKSPSARRPIILRPPSMHSTRTRLSPHLERSTSTYSYTGDSSVSGMSAHQQALLNDVIKEEDKANKDAQREEKEDLAKEKAEVMKEQEKRKKESQGETVVSGLVTKRRTRKGTGLSLNSRNSDRGESETGPFTRSNSNNRQSSEAPHEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKY0</accession>
    <name>A0ABR3BKY0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611470.1">
        <property type="nucleotide sequence ID" value="XM_066760166.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992571"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="123" mass="13306" checksum="F5CAA6E976E5A4EB" modified="2025-10-08" version="1">MGEGGVGGHDASAAFAADLNRWAEQRHSETLGMIPSPFVPNPNPFPSSFPNQAAFATKPREKSAPAPKPLVQQRDSRPAYPPCCDFGYRLLRSRPSPAPPSSTTYRRSTTQDHLPPSTGSNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKY1</accession>
    <name>A0ABR3BKY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610905.1">
        <property type="nucleotide sequence ID" value="XM_066761080.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993513"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="48192" checksum="5209D9636998AA92" modified="2025-10-08" version="1">MSEATAEIAAAFAFPTSSLNPHLDRGMKYVYPKYVSLLFLGTHLLAFSAVNIFHPHLYKEEIPHFNQVLHYARGDFEYHDESMHTSTLWHYAISIPFYLLGITPTLSTLRLTCLFQALLLPTILTIALTPTPSPNPFFPRRFINVFCKPKDYALTIGLNSMVVLMASRFTPGISCLLGLLVLWRSVLKRRYWIGAGVATVIGVMRAGVMVWTAFVLGWVAWGIAMTDRERKHRACTYYPYLFTLVIWWFVWRKQNIPFDWSGIGDFYAFTQLTQPMLPVWAPYSIYLLRHFRWMLLWAFATLCSYTVSDNSRNRVANTVDQCLPLIILRLYLLFLGDKPKESAPAIEGRDGPRTTVAGGELETREQVKGGTSPEEIRQPQTARAAEDGNERGERSQPPNRQRIEAGWYTLISLVAGSLILIIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLB2</accession>
    <name>A0ABR3BLB2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610743.1">
        <property type="nucleotide sequence ID" value="XM_066761203.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993637"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="69" mass="7989" checksum="395FDC6CEEBD2112" modified="2025-10-08" version="1">MIIPVRCFSCGKVIGNLWDSYLELLAAGVDEGEAMDKLQLKRYCCRRMVLTHVDLIEKLLMYNPLARDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLG7</accession>
    <name>A0ABR3BLG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611836.1">
        <property type="nucleotide sequence ID" value="XM_066759890.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992290"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="49056" checksum="433801B6272D63FF" modified="2025-10-08" version="1">MFRPAALLFRRRIANLPQRQFSTSLPRPRAPIPIPDTPTAPPLPLPDANPLELPRSLSPTRALLLLSTPSPPTDWPSHLEMHSPLLAATSGKLKARGVGVNVVYDPAATYGSLGFPGKEVEGEEKFMARLFWPDGRKVEWDVFNLETLNSDQLEEAINYTPSLSHSSGLPQLLPASETSQKEILVCTHGSRDCRCSDRGVPLVSALRKEVNRRGLESQIRIGQVAHVGGHKYAANAILLPTMDMLSNLSTEHAPCIIDHLFALAPSIPSASVIPVAERGTKIDKSTHVKGEGMWKHWRGRYGLTLEQQALLWDSVDPSHHPHIASTSHETAAKNVQETVTLRFKTFEGEEKVVHARVGENLLEVGKENDLPSLEGVCDGNLECATCHLYLSSSPAPPVSEPSEAEDDMLGYAIGYKEGESRLGCQIEVTRDLAKWCDEGGIIRLPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLJ5</accession>
    <name>A0ABR3BLJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transitional endoplasmic reticulum ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612026.1">
        <property type="nucleotide sequence ID" value="XM_066760080.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992482"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="8">
        <location>
            <begin position="27"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="7">
        <location>
            <begin position="127"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="239"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="565"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0243659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="65943" checksum="B1E80558D8D68C3B" modified="2025-10-08" version="1">MADDPSRPVQDDSTATAILRQKRSPNRLVVDESPSDDNSVAILHPNTMEALGLFRGDTIIVRGKRRRDTVLICLSQDDIEEGKVAMNKVARGNCAIKLGDLVHVAAANDIKYGKRIHVLPFADSIEGLSGNLFDVYLRPYFLEAYRPVRKGDVFQVRGGMRTVDFKVVEVDPSPYCIVASETVIHTEGDPLDREAEEATLNDVGYDDLGGCRKQLAQIRELVELPLRHPQLFKAIGIKPPRGILMYGPPGTGKTLMARAVANETAAMQQIREKMDLIDLDEDTIDAEVLDSLGVTMENFRFALGVNNPSALRETVVEIPTTTWNDIGGLDKVKRELQETVQFPVEHPEKFLKYGMSPSKGVLFYGPPGTGKTLLAKASAGDGGGSSDRVLNQILTEMDGMNAKKNVFIIGATNRPDQIDSALLRPGRLDQLIYIPLPDEESRLSILKATLRKSPIDPRVDLDFLAKNTAGFSGADLTEICQRAAKLAIRASIDSDIRKERERNEKAEAAGQDVELIDEENEEDEVPAITVEHFEEAMRYARRSVSDADIRRYEMFSTTLQQSRSFGSNFKFPESGQTDNAAAGATFQNEADDDDLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLR5</accession>
    <name>A0ABR3BLR5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611205.1">
        <property type="nucleotide sequence ID" value="XM_066760933.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993361"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="251" mass="26690" checksum="3FC855CBF78CFF0A" modified="2025-10-08" version="1">MHRDLQGRICAVTGAAGRIGRAIVESLARAGGTVVALDVAEGLHFDTGGPGKVECVTCDLSDPTSIQEFEAHVRRQYGQLDCVINNGAIGGGMVPLHAKDLKEYSSIMDINVRGSFLLMQAALRLHINRRKASEDQQQLVIVNVASTAASHPELLGSIYSMSKAALVSLTKSVAKEYGDQQVRCVAVSPGMMDVPNVQGFSPSNLAKLIKSIPLQRSGAPHEIANLITWLVSDEASYVTGTEIIIDGGRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMF4</accession>
    <name>A0ABR3BMF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_106432</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611133.1">
        <property type="nucleotide sequence ID" value="XM_066760861.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993287"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01874">
        <property type="entry name" value="DNAREPAIRADA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1124"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1157"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1200"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1238"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1267"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1390"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="94"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="783"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0240634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1420" mass="158158" checksum="D82FDA1DD936571A" modified="2025-10-08" version="1">MTHRNDDPEATAVQSAASSSPSLLTGDETNLARISKKDHAEGVPASHGKIFDQPGSIPLPNAGYHSLGVVWEDVTVYGAGGGKKYVESFEVSIFKLWDVYSFAKKLFRITTGPTRPLIRSFSGVAEEGEVLLVLGRPGAGCSTLMRALANVPEPFVKIEGDVSYSSIPAHEAKKYYDGEIIFNSEDDEHQPLLTVEETIKSALLLKEPHKKEDKRKRSEYVESLFARILDTFGMPHTRNTMVGNQFVRGVSGGERKRVSLAEVLTTNAAVICWDNPIRGLDSAVALHFYRVLRELSKSLGMVNIISTYQTAQDAWDCVDRVVVIYEGRQIFSGRASRAQTYFENMGWYKKPRQTTPDFLTAVTSSNERKVRDGFKGQVPQTPEEFEQYFLESQEYKDLQQDIQRYKERQAQSSNAEEFRTAVKNSKHPGAGKSTPYRVNFAQQVAILCKRQLQLTRTDMTSFVYRIGSNVLQAVLVGAVCYKPPNNSAGSFAIAGALFFCILYYTIFALGEVPATVNSRPLLKKHRALGFYHPAAHTLAQIVCDIPVYVFQTLLFSAVFYFMVGLTVGAKYFFTFWFVIFTMYEAISVMYRMIGSWTPNMSVAIRYGCLALSVVLSSSGFALPPPRQLRWISWLQRATPCSWAFEALMANEFRARTLSCSPTDLIPSGPGYDNIQYQVCSINGAQPGFVNVAGMDYVNFVYGSQVSHIWRNVGILWAYFVVYVIMIVIGSSLLIRESPDSSQKVYKRGGKAIIMETEEKAEEGKAAMEKVQRPKGSGDEVPVYTFEDVHYTVQVAGKDKPLLNGINGYVKGGSLTALMGASGAGKTTLLDTISLRKTTGKVEGKMTIDGKPLDASFSRQTGFAMQADIHEPMSTVRECLQFSALLRQSNDRTREERLEFAENIIKLLELEDIADALIGAPGEDGLGVEERKRVTIGVELAADPEFLLFLDEPTSGLDSQASYEIVRFLKRIAASGLAVLCTIHQPSGDLFEMFDSVVLLAPGGHTVYVGETGENAATVVKYFGDRGAYCPPEANPAEFILGTVAPVGGTDTDWPTLWKQSDEAAEVRRRINEYTLRNNSGNIESEKAVTKVQQKSGNDAYASSFMTMTRELVIRNFRAQWRDGSFWTTQIVILIYFGLYIGFFFYKLDHTPNNMTPASLSLLVAVQALPGIAMDIGMNYLAKMDMFLARERLGIYSWQALVTSLLVVSMPVLFVGWNLLFFCFYWTVGLVGTRADGVLVWLCFMSSSVLNAGFGVLLGAVSPNRLSLPYILSLVWNLLNVLSWALVFYSGLPSPFHYFFSWLSPLRYLYSALMTGSLGNLKLECIEEDLVTFFPPSGQTCYEYAANYLATTSGYLVDGNSTTSCQYCASSTGYDYVQQMGYSHGTKWRDWAITIIWCLSNVFFCFLFTWAIKIRPLYKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMK0</accession>
    <name>A0ABR3BMK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612371.1">
        <property type="nucleotide sequence ID" value="XM_066759724.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992123"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="3">
        <location>
            <begin position="6"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0244004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="224" mass="25060" checksum="1B559267408CA10B" modified="2025-10-08" version="1">MRSSTSVLPAPYFYFFWLLEPILTVAGGVSAIYDPISFGGNTLPRNIERATLKMGNTVRGQIVVSELGSCFMLLAMISFSLFYLFKRHLEDKPVLQEKLVKGLLIPLAVADVLHIAVTLLPLPMSHLENPSQWTYILHSTVWITSSLFIVRLAWLFGIGRATAKSMLESRRSPTRQARLPLPKGNSEAMVEQVVQTEKPREHTAVESPATIKKRGRAKKIVDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BML0</accession>
    <name>A0ABR3BML0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612392.1">
        <property type="nucleotide sequence ID" value="XM_066759745.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992144"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="191"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0244025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="381" mass="42933" checksum="7C1D7294A0E68E69" modified="2025-10-08" version="1">MPIATKTYPITPFDRPAPTTEDLHWADLTELPLDLFYHAKGRSRLVEGVKHALKVDDLGFWSVTNAGFSDEEIDHQFAISQAFFNLPIEEKKSNAIDAKNDGYLGYRAPYERTIADTDVLDNMELVNIPKYTDDYKVYPRHDIFKAHEAVIAEFHRKCWHQIAKPLFVLFALAMELPENYSVERHEYGKPSQDHLRYMQYHPRTPDDDVKCNNLWSWAHTDYGSLTLLFSQTVSGLQVKFSDGSYRDIKYKKGSVVVNIADTLSFMTKGYLRSTIHRVTVPPGIQSSIHRIGVLYGCRPNDNVPVITAPSPLLEHLGLISDADRNAKEEDAVTAGEYVAARVKAVHGSNTYGTAPGTKFKHKNLEVLENFADSSSGKKGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN30</accession>
    <name>A0ABR3BN30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ESCRT-II complex subunit VPS25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612039.1">
        <property type="nucleotide sequence ID" value="XM_066760093.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992495"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23819" checksum="805951DE035093B0" modified="2025-10-08" version="1">MSSQSVTLPSKAPREMAPTPLRSHKSAGGFEYPAIWSFPPFFTLQPNPQTLAHQLQLWRTLVLDWSRHERVFEVNTDSTGKDVLEVFENRTINRRLLPPSQKTLMDEMVKNGEAAAYPPKQDSQYLIYWRKPEEWGDIIYHWVMDNGLNSSIMTFYEITNGDLSHTSEFYELPISVLRKALETLVKRGRAQIIEGKDEIGEGVRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN45</accession>
    <name>A0ABR3BN45_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611700.1">
        <property type="nucleotide sequence ID" value="XM_066760396.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992802"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="3">
        <location>
            <begin position="77"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0242318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="456" mass="49824" checksum="80D4F59A56F0AF05" modified="2025-10-08" version="1">MGVSDYFTAFSAKFWGRLRFPSKFTRDVVWGIILGITLSLSSTSAALILQEWRRKRATQRIPPRPIELRSDEIVPGVTGLIGNTPLIRINSLSDALGVEILGKAEFLNPGGSVKDRVALQIIEDAEAQGLLYPNTGSVLFEGTVGSTGISLATVGKAKGYESCIIMPDDVAIEKVQILEKLGARVERVRPASIVDQKQNLARKRALEFGKSEITNIPGHGEEIAVSTDAEPSEINHHHLFPSAFEYKPRGFFADQFENDSNFMAHYKGTGPEILRQTSGNLDGFVSGAGTGGTIAGTGCFLKKALPDLKIVLSDPEGSGLFNKVRFNVMFDPKESEGKKRRHQVDTVVEGIGINRITYNFSLGLPIIDDAYRVSDEEAVAMSRYLVQHDGLFLGSSSACNLIACVRLAKTMSRGSRIVTILCDSGSRHQSKFWSDDYLRANDIAIDPSIVDRLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN82</accession>
    <name>A0ABR3BN82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="5">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104647</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612599.1">
        <property type="nucleotide sequence ID" value="XM_066759112.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991503"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="7">
        <location>
            <begin position="136"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="8">
        <location>
            <begin position="371"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0245515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="494" mass="54594" checksum="89F33A76A38F12F2" modified="2025-10-08" version="1">MVHDPRVSDGQLAHINAAAAVRELPYCLRRQRFPSYNEIVQLTLPDGTTRGGQVLELTGQVFEGTSGVDTKATRISFSGSSMKLAVSEDMLGRVFNGSGNPIDNGPKVFAEDYLDINGSPINPYSRIYPEEMIQTGISTIDTMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKRPGATKGVHDGHEDNFSIVFAAMGVNMETARFFKQDFEESGSISNSTLFVNLASDPTIERIITPRLALTTAEYFAYQLERHVLVVMTDMSSYADALREVSAAREEVPGRRGYPGYLYTDLATLYERAGRVEGRNGSITQVPILTMPNDDITHPIPDLTGYITEGQIFVDRQLHNRQIYPPINVLPSLSRLMKSAIGEKLTRKDHGDVSNQLYAKYAVGKDAASMKAVVGEEALSADDKLALEFLDRFEKEFVGQGAYEARTIFESLDIAWELLRIFPKESLNRISPKILAEFYARKPKGTTGSEQPEENKEENLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNC1</accession>
    <name>A0ABR3BNC1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612644.1">
        <property type="nucleotide sequence ID" value="XM_066759157.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991548"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="418" mass="46745" checksum="0F1A0627507C0E72" modified="2025-10-08" version="1">MKVDGEEKRISYRQQPNDESGNVKTLQKKKSFFGSANLKKKVKGLASQIMKGKPASPTAAATPLTEPPLSAPQRKSQRMARPPLHKASHTLQDSLPGGNRPKANQVFPPKKPRKTASWPPPKNSQISSNRLPFTKQSNNVHYRPSSVYINDLRKAIKMDTGHMLNVPFFRAAPITRPNSYCILQRQLARLQLCDEALTKRVDRHSQETICADKDETNKATDTKKPSLLKQYSCVSFDQETGQSLSAISSLSSDGNPSGLSTPSLTNGSSQTSFFELKRVSSLLTTIRSEKSSHNEVLVGVSDQTFNRSSNPSISDFRKHSRESKHRTKRQSEKRKDITPETFACQFDRSSQSERPRTHHPDAIYARKVSKEKLNVGPAYPNQRRRPAEVGRAKNLRGPLATSDQIPDVDSMLSIYAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNE4</accession>
    <name>A0ABR3BNE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tetrapyrrole biosynthesis uroporphyrinogen III synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612355.1">
        <property type="nucleotide sequence ID" value="XM_066759708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992107"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="288" mass="31853" checksum="533E47F356E3C8F4" modified="2025-10-08" version="1">MSENSQLQSLETTPVILFKTPNPSPSTDPYHYAFSKSASSSPNTAGEYKLYFIPVLQESYDLPEIVKIIEQGPEPWEGVIVTSRRGMEGWVKGVQIYLGGIGKGKEREGAWDVLPLFSVGHASTEHLAAADIPPSFKPRPVPEMESDPPKSAIPLSELILRTSSRRNTGAGGVNYRPYLFLCGDKSLDEMPTTLRSEGRTVKEVMVYATSARDDFQGGFGRLEIPIKSKGWLAFFSPSSAAIVMPQIKQDQGRWDGWRVFAIGETTKRYLEEEAKIEIGTLHPSDISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNK8</accession>
    <name>A0ABR3BNK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612740.1">
        <property type="nucleotide sequence ID" value="XM_066759253.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991646"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="10">
        <location>
            <begin position="36"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0245656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="305" mass="33609" checksum="40D6C972C11A736F" modified="2025-10-08" version="1">MSVSIDPVNLVPVPPLRDSYVFHSPLPVAEQNSEEGWIMGIDEAGRGRPMVYAAAYCPLSFKPTLESIGFDDSKALSAETRQTLWETFEAHSPLCYSSSTLSPQDISSGMLRKVPINLNRQAEDSTVGLIQAALNRGINVTECYVDALGPAPQWQARLTAIFPAIKFTVCPKADSLFKIVGAASIVAKVTRDRYVHGWVDPEDVVHRATDVKSEDEEEVIRGSGYPSDPKTQAYLKKSIDPVFGYKGIVRFSWATIKVLLDKQGVESKWIDDTTQRSAANRFSTGTDNERPKVWRDLGVSSVGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNY4</accession>
    <name>A0ABR3BNY4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612867.1">
        <property type="nucleotide sequence ID" value="XM_066759380.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991775"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="446" mass="49007" checksum="59CA5C7786D7BA33" modified="2025-10-08" version="1">MAKKKSVNAPISIQPASGKRITFGEDDGGSLECGTEGEPSGSGTKNVKQDSEDETEEDSDDEAPEAIAMNAAHEAERAIAQRKAAEREAKSKAARARSQAIANAKQEKREAKAQPQVENKGKGKIVSAKADKKGKRQAESEDENEDEDEDEETRRLRKRMEAAMAQVSDEESNLDDDDEGQDDIFSGSEEDFDDQQSFHTDSDIAHFSGEEGLEDDDDDGDESDDSEKLENLPMDSKSKAMWAQMQAMMEAAEKRAGIASDLGDSEKTRENGKTQERKTKVRKRKAEEESEHEVEAESDDEEEDEGDDDAQWDLAPGVKPLSKSVIQAAVKAEEEKKVREAEKKASQKVEQGVKQSRRKKRKVAKLETSRKVSDKTTLHLLPQTFSSTDSTSFPPVINARSRPGGTAPAGKAAVNKFYKRAMKNSGVVPGRGPLDGRRRAVGHVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP40</accession>
    <name>A0ABR3BP40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612923.1">
        <property type="nucleotide sequence ID" value="XM_066759436.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991832"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF8">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="307" mass="34770" checksum="589929F2C9CA8034" modified="2025-10-08" version="1">MLANQLAKSMEIGMQMPRIMYGTAWKKERTAELVSQAVKAGFRGIDTACQPKHYREDLVGQAIKSLISEGVVKREELYIQTKFTSIDGQDPSLTLPYDPLSPVEEQVKQSFETSLKNLGVEYIDAVVLHSPLKSREDTLKAYLTLSRFLSTKQVRHLGISNCYDPLLLKWLIDSVAEYSSKHQEEPEVKVEIVQNRWYEGNGWDWDIYNICRGHDIRYQSFWTLTGSPTLLKQPFLINLAAKYGLTPEQTIYKLCQLWGITPLCGTTSLAHAKEAVSVENATGLMSSTEEVVKLWNAMGGRYTEGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP81</accession>
    <name>A0ABR3BP81_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hyaluronan-mediated motility receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612968.1">
        <property type="nucleotide sequence ID" value="XM_066758520.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990896"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031794">
        <property type="entry name" value="HMMR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15908">
        <property type="entry name" value="HMMR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan-mediated motility receptor C-terminal" evidence="5">
        <location>
            <begin position="491"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="43"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="188"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="462"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="649" mass="74846" checksum="ACB0FF609C8915CE" modified="2025-10-08" version="1">MTEGHKVRRPLGERMLPNEDVYRDLKEHGIHKGAAQGDNKDYVKLLERHLFEAKCQLERAKAKIGRRDETIKRLSQTRQLPTDFKAGDLETKLEDLTNQHSVLKAKYQNQVGDLELQNMKLQEELDLLRSSHRSSQDELDSLRKRQTQTLIDFDALRIVLADQKDKAITQKGEDRMLERGRIKWEGERSRMKMRIEELKESKERSDKKREELKLEVGKLKQQAKLSSKEIRALKEEVKQVNAANDSLEETIEACTVSYCALHRNTIRIEEYRVLEQSYLETKSELWRWKLKNEIDTLDLERKRMEAGNLRERLKTVEDERMILKAVIKDIKDDQQALRNEITEFALTIGNRNLWDFVADLSEVTPTPQDFLSVTLNHINLSSSYYTQQIETLNSANESFTSKLSTTTSNLSTCQSALADLQREHSDLRTRHSALEKAHEPCDGVREELLATEKECMFRGQKIEGLEEDLQRMEIKSRDDAEKVKRANELVTRAKSAEQALDEEIQHLRKAYIEASQYQELYNDLQEQHEMILARETAAIEEAERLAMHNAELVGHSNDVQKVSYVEGVRREMALVKQELATTRHLLNNANDKVQTLENEIAAYKSVDAGLDGLNLGTSTRTRVVRRQPEGGQLAVSKIGRSISGPNGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPE4</accession>
    <name>A0ABR3BPE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105452</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Vacuole membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611853.1">
        <property type="nucleotide sequence ID" value="XM_066759907.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992307"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="9">
        <location>
            <begin position="121"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="10">
        <location>
            <begin position="918"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="854"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="535"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="655"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="744"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="881"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1046"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1118"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1156"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1192"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1274"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1296"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1306"/>
            <end position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0243486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1370" mass="151434" checksum="22AE94B1EC04D1F6" modified="2025-10-08" version="1">MEIYQASDGGLYRLDAYLDSYDDIDAVYQDVSAATGIADHNVLLFLENGRELKSDVLFDLRNQAGPSYNTGPPIKVYMYNRETFWTDAETWAVQMQEDVQLPPPLDLSSFNGIQHPFLVAHDHLSHLKSLSDTQSKALQIAYANLSQHLQPLVDEFQSFASRVEASFKTEEELIKSAKLDMALLPKLVINPALLKKKDDEGKVRTMGDYVNAKKMEQVRESCRILHVENVDRFNSLAASLDDLVSQSEAEMAAFNDRSAEIENEFADGLARLEVALGQLSQLSGSGAADVHQDFTELDQAMRNDLVALTAVKNEFTFDIHLHLRQVAHFQSQIHELIEPLRKFDADLLASKDRSAFPHLYRLHQIPFAYAAAVSEVVRRRDFGQMLTEWTKRLRGTLNTFTQVEAKRREQVNKESLSQLPFSVPILSESQAPKVEVTLVTGVEALGNKAFGYEEVEKLASWLEQMRNDPEVIADMEDGDAERLHAMQTSIEGLIMRFDTTADELDRMVEQGVFHPKSQTRSASNSRTLLHLSSQLHTVNKDKTEYEKRLQELEESHRNHLQSLTEQHEKREQALQMRQGELQEELARLRTDLSEEMLARQALTAELEEKTREQEDWRRDHEDQMEMVAGLQAELTQEKDRATDLGMRLQEALLDVDGLKSAEQTLITQLQELQEERKKALESENEAQAIVKNLESQLAGIKAELEAVTGQLTKAQEDRETALRSQSAEAEKLMRDRITEADGDRAVLEHQHLILTKELDNLKLETEKKLAAAQNTAIRQVDGLKAELSLTKAQMRELQRKELTLTDELAVARDTMRVLTQEKGHGAEHAREAVSLVTKYYEACQRLLHAISTSTTISGSAAQPRSRTPPPLNQPPSKHHINQSPAASTSLSASGKDEMHESMSLVAAQDFDLAEFTEAVTKTIGLVKKWSKSCRQYRDQARNKISFTNFAKGDLALFLPTRNTASRSWAAFNISAPHNFLKVDDILQEQLKTREWIIARIVKTDEAVASGGESLESNPFGLADGLRYCVHTVEEYSVGTSRPYRRNVSSSFTGSQILPSSHRPISSGGGHAIRRAGMTSIGAGPGQAEPQNEYSPTKEAGDDVSMSGITEQKMESEGDGQNKSQYPSSTGSFQPSSESSPVKTVPPLPWPSLLPSNIDQEASVPISSDHSSKAMSLPPSTITPHIQPLNHVSSRSSKGSSSTLGHPTSPPSRGEYLSNLNPANFTARPPSVASSNSSYPRGIGLGPGPGGKATLAPAMTVTTSHDKGGEDLYDNAQSPFRVTSPVSEASSSPEKGKKTHSSRASKSHFSALGTSPGDTAGGTSALRTGMATMGKRRESKSSIQSDGKVSAIDILRKIDKSSGTNLKDGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPL5</accession>
    <name>A0ABR3BPL5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inositol monophosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613100.1">
        <property type="nucleotide sequence ID" value="XM_066758652.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991030"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01637">
        <property type="entry name" value="IMPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28858" checksum="493019206032F932" modified="2025-10-08" version="1">MEYSEIFDFAYDLAEKASKLILEASAKRWVSTSDLNEKKNSVDLVTETDELVEQMIKSAVAEKYPHHKFIGEESFAAGDRSPLTDEFTWIGTMNPFVACSIGVAHMTRPVVGVIALPFLNQIFSAQLGGGAYMNRNIPLPLTGGIPQPLSDLSRCMIGAECVDGGVMAHALRTTGSTACNAVAVAAGQLDIYWMLSLGRLPIILNETGGFFAGGKDSLDAPVGQVMMGRRYIFVRAVPATEIQHRLARELYDVVDEWTNEDMMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPL8</accession>
    <name>A0ABR3BPL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THO complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613079.1">
        <property type="nucleotide sequence ID" value="XM_066758631.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991009"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="763" mass="86027" checksum="6D7F3E93A814C2D3" modified="2025-10-08" version="1">MEIHQSLLGPLNSILSAYPPERSKPAPIPASELQSKLSQAWETYSNDPSLMNGTAKNPDLVRAVLELVGREFVVLSIVNGELSEPDETANEKEKIAFQAALKDRLDIILTLYETVHRAFQEIPLLEPGTLFIPLLEELVELLSVSTWRSLWSYVESRSKRFTKDMPASRGKALPLLRTINAFLRFLPRTPEDLVFRGRIHQFASSVFSVADKSAINMRGDYSEVKTIWEEEPKVEESKVDGGKKEEKTEEKAEEEGKKDGDIEMEDAEKKDEPTERPVDQPADQSMEQPTEDEPPLTPATLQDPDFYSTLWSLQQYFSHPPSLDGPAVGSPPKTPFQTFRDKSDFVLPQLFEQTKKEKAMTGTENGMGKKRKREAMEGHNTGGFFHPRFLTGKRLFEYELADSSFRRQILVQYFILFQFLLNLTPAHAGKQAFTGGMPRTFTLEQADEQWVKSKIGGIKEELKRIIGGTSFEDTVFSIIRQEAHYVQWKNEGCPEGSFEIPALDPDSASEPAQAWAKRLNPPAPYNFKVGSRPLSMLWNNGFTNINQLKGREKATTVEALDEEIKRIEEDEEDDKAMGQATSEKLAANKERKTTSTWRALRLASQTSLKFFPSLKEKRDVHLLLSTIKKAQEPRGLAPKEDGEGEKEEGEGENENTGEGEGEELEDEDEDVQELKTEKEGEETEEKEKEVVENAEKKGSAEIEKAEEEVKEELAVDEVKIEEAGEGKEDKSDEKGSADVEMVENEEQNVESKAHDDEVETSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPZ2</accession>
    <name>A0ABR3BPZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="12" type="ORF">I308_105650</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612048.1">
        <property type="nucleotide sequence ID" value="XM_066760102.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992505"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0243681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="187" mass="21422" checksum="605840BF4BCCD60B" modified="2025-10-08" version="1">MKAYIYDDKPGDQRLPHDTGIDIPEPTLAKLGVIYRRIPIDSEGVWESKIDEFAKERGYKNRDRITVTREGLGEAYEEKIKSFFDEHLHEDEEIRYILAGSGYFDIRGAEGVHEEQWIRIALEAGDLIVLPAGIYHRFTVDSANTITAMRLFQDEPKWTPYSRQADGTDKLGSRDKYLETVRVGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ86</accession>
    <name>A0ABR3BQ86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exostosin GT47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613310.1">
        <property type="nucleotide sequence ID" value="XM_066758862.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991241"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08946">
        <property type="entry name" value="SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF73">
        <property type="entry name" value="EXOSTOSIN-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="92"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="4">
        <location>
            <begin position="915"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1148" mass="127325" checksum="9FA1E1071C7F68E5" modified="2025-10-08" version="1">MAPSQPSVRLLLLPLIKSRFLALLILPLVVLILYKNQLSKQPSLKVKVKEAPQGGSWEALADMDDDWGIHEDSWGGGVKDWFGWRDKGGTSIIITGGAGQLAQALIPELISNYTVHVHDIVPRPPSLPSSVIYHRSSISPAEAYKSIFTSNIFDGVIHLAGISLDAWCAAKEDECHKVNAGGTKALMDEVIAVNKQSKRGKMWKDVRVPWVILGSTMEVFGPEGTNEDSPKNPTSAIGRTKLTAEQVFEEALLDGASEGIRGLVLRFPEVYGYSSASSIPEAFIPSLLTNSLTSLPIQYSSDQIPYDLLHAEDAINGFVKAISYIEATPGGGVSSINLVSGQRTPARDIVELVRKETTSMSPVRDIGNNRNPSAHEYSRAKAAEILGWQAEITPLVGLGKAITQLTEDIGTYSRSYLHEHCPPSADFPASDDDLAVSFIEDERNKPLWKLAGCTVNLGFNHEGWFHHLKCQDGKHCKVDDVKVTALNWNQSTFIIEKVGKKQRKRVVRVMLREQTGMGYLGMTKTEGEVGLELYSDSKEGQTVFDLEVRRDSSSLRLLVPDSEMQLHAISNDTDGSTWFTVEPITRWVDPHFDMRVNVLCCPFEGDWPLLLDDYESADVRFGSTGQIPFYSTRRSHLCTRAEQAVRYNFKHLSTARQAVNKVTSTAGHAFFSETGPKTDPHPHAWALKDLPACWNDCGSPPVCVQTGNCKCVQADHCKPQRENPLLKIYPSNSLHPDENKLTLGSLAGYSPVLVEAVEAIDWKDVLLPTAQAALGAHPDFVKVHVADGYKGQEEIEAASCHKLREIDCFSADSIMYRALRHMSVPADEAELVVVPVYQQCEGTQFLLHDAMHHASETIQGVKNGEKKVALVLTHDWGICVDFAWQVIYVGCFCPCLQRSRYRDIWSARGEHALHPDEILKNALVWSVMGDYDSPCYRPHQDVVIPARTCRSNTLRETYPNVGTIKPMRERSNLLMWSGTYSGTGKSERIRLTCNRGGAGDRELIKGGGKQSNFASSDYMKDLNNARFCPQPRGIAGWSPQTSDAIYAGCIPVFISEGTQYPFADFLDWSKLSVRVAPTELDKIEKVLAAIPLSKVEELQANLVSVREAFLYSNDETPEDELERRGPMFFALHEAGMRIRTRYPIKGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQQ1</accession>
    <name>A0ABR3BQQ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613478.1">
        <property type="nucleotide sequence ID" value="XM_066758076.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990441"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42871" checksum="8603E6478E6C9C1B" modified="2025-10-08" version="1">MSAQPSRPPSSTSNKSALEENKPEGADVPDEQKAGWASFIKSLARMTGDLSSMTAPPFILSPTSLTEFPAYWCEHPAAFASISEGKDQFDRSERTRNEKMGSEKKPLNPVLGELFYGVWPDENGRGETKLVVEQVSHHPPITAYYIENVKAGVKLQGHSGQKTSFTGTSINVKQSGHAILTVKPKNGDPEERYLITLPKLRIDGIIWGSPYIELTETNAIQSSTGYTSQIDYKGKGYFSGKAHSFKATITKSGKTLQSYEGQWTGNSYIGKKNGHLFLDMNEAKEEVTVKPIEEQGEWESRKLWEKVAKGIRSQNYDEAGREKSRIENEQRQRRKDEAAAGITWQHVHFTHVDSDEEYQSLAELLHDKLTPTHEDAYVFKGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQX0</accession>
    <name>A0ABR3BQX0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613551.1">
        <property type="nucleotide sequence ID" value="XM_066758149.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990520"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06152">
        <property type="entry name" value="YjgF_YER057c_UK114_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="141" mass="16247" checksum="6EF294FF1E8BDC26" modified="2025-10-08" version="1">MSDLQYFNYKGYGTEKAEKQFRYSQAVRVGDTIQCSGQGGWDPETGDFPKTKEINAQIDQAFRNVDLALKAAGSKGWEQVYRVNSYHLPLNDESQEAMVRNFRKWMPDHNPLWTCVGVTRLGFDDMRVEIEVQAYAPKDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR59</accession>
    <name>A0ABR3BR59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">malate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104178</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613104.1">
        <property type="nucleotide sequence ID" value="XM_066758656.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991034"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="148"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0247143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="335" mass="34520" checksum="F24D40C631696AD0" modified="2025-10-08" version="1">MVKAVVCGAAGGIGQPLSLLLKLNPLITELSLYDVVNAPGVATDLSHIATPAQVAGFLPPDNGAEKALKGADIVVIPAGVPRKPGMTRDDLFINAGICATLAQSIANACPEAFILVISNPVNSTVPVFAETLKKAGVFNPKKLFGVSHLDVVRASTFVASVVGKPKDAAKYSVPVVGGHSGATILPLLSQAKPSIDAILSDKEKRDALVHRIQFGGDEVVKAKDGAGSATLSMAQAGAEFADFVLQAAYGSQKGKVVQSYVFLGADAGGKEIKKEIGADLDYFSVNVELGPNGIEKILPIGKIDEAEKTLLAAAVKELGPSIEKGASFQPPPPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR96</accession>
    <name>A0ABR3BR96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613649.1">
        <property type="nucleotide sequence ID" value="XM_066758247.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990622"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="251" mass="27485" checksum="3CAF4A060A1FF94C" modified="2025-10-08" version="1">MPGQKHLLDIDPEDLVSFHTATSSTGCGQGEVVRAHKRSRQCTPSPHQHTPSPQLAANVSQSSRSPPALLSESNIRTTHGASSSLDLTDCPKQTRKDWCARLFASSPSSSHWSNNSASPVAISHSTPTRQRDQSSSFMPSLDSEPTIYQHPDASIRSELQENEEVILGITSYPSPRYKHDGCSPKPAASNGFHHILSGLNHLRIRDQYTTRSPESLSRSTSSRRAMTLQAPPSGSSRRCFAIYGDNNEQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRB2</accession>
    <name>A0ABR3BRB2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_103781</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613664.1">
        <property type="nucleotide sequence ID" value="XM_066758262.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990637"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="416"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="269"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="514"/>
            <end position="521"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0247703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="772" mass="83642" checksum="0E5EB6CC231F9335" modified="2025-10-08" version="1">MEQENNPPLLSRLPRLASPTKPSSIPVPSAASSIPHMPPLTSDNNANTGVSKRKMPSSPMRPPVAKRSVSGEAPPLPASTLSKSTMGAAASAGLRTSQRKPTSGGFVPKPKAPASRPATSLGVSTRRTTGSSGSASSASSSGATVRPTGSRSRSGLAPPARPPTALGTSRLGAMTRAGSALGRSTGPTTRIGARVPAPSGAAKDHDGRLENVEMMLGNFHHLFEAEQAKISTLQSSQESLQALLQSTQMTERAARLDLTSASEEIAALRSSHAREVDELERTIARKDREKKNLEDELRDGRDELSRERDIVRALKVQLSEQSTKHLTLEAQLSASQTQLTNLQSEVERATLAVSAMKAELQVGQDRARDVELKAEKKVREAEEERDRRIAEIEEELRTAETIRRKLHNQVQELKGNIRVFARVRPVLPHELSNPEGVADIAYGDERTAQETGQSQIVVTSKSESATGKEREQINQFTFDKIFAPKAGQKEVFEEISMLAQSVLDGYNVCIFAYGQTGSGKSWTMEGAQDEENAGLIPRAIDMIFKVSGQLKDRGWKYQMEGQFLEVYNEVINDLLGNGQFDTKKHEIKLDKDGKISVTEAVSVPLSNPRQVHTLLERAQSRRAVAATLMNERSSRSHSVFTLKVRGINPLTDEKCEAMLNLVDLAGSERIEKSGAGENKDRLKEAININKSLSALADVIGALGQGQQGGHVPYRNSTLTRLLQTSLSGSSKTLMLCNLSPLATHLGETLCSLRFATKVNTTQVGQAKKAISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRJ2</accession>
    <name>A0ABR3BRJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613776.1">
        <property type="nucleotide sequence ID" value="XM_066758374.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990749"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="338"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="338"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="547"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="558"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="618" mass="65882" checksum="0B0179FD01CDD72C" modified="2025-10-08" version="1">MFAMPNTPTHDRGSPWSRYITPDLTPSFPTSSFIERTLSTQSLNHQPFSSPSPTSSHSLALASPVQTPFDPPSIQRQSTPVILEEGFHSNPMHAAYPNSPSPQPFGIIGGLLVSEPASMLQHPSSDCGTVLHSDIFLSQPVSKTSRPALRSSLSNNTVLDTPSPSIWPRRSMAISALSTSAVPTPGSNQRVPADGTPSGSAVAGQNNNEAMTVQHEANTPSLSHSATSTTSTSVTASQQAILSSSSSSTHPYGYPQYAALFNDASSSSEYPYNPSPYGTPAYASTPYPQPNWQMTSISHAIAHKQQQPQYHWGDVHAATMPGKQDEPILAAGELPAPRPPMSYAALIGETLLLASPPHQLYVSEISDSIKKRYPYYRQNPTKIYNGVRHQTSMCKAFVKLPRPFGDQTGGARKWGIRAGCEGWFAGGGYHPPSNAVTTNKPNKSRKAKSTARSKLLAVGMSGGKKLPPGFPSPTSSDGPSSGPAYDGSSGAVAPYQQPYSAAAFSSPATNSHLPPGYHYIPVNSSQNYTQPQPIYVPVWGPYAAPNPPPQYQGHFDHGSQSPETWRRQVSGTQSSDGASLGSSFDEVKVLPTMGSPTGSIHSFRESLHSPHGNSPETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRU9</accession>
    <name>A0ABR3BRU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NAD+ kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612723.1">
        <property type="nucleotide sequence ID" value="XM_066759236.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991629"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0245639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="60734" checksum="E5FC37E87C94144D" modified="2025-10-08" version="1">MSPASSYQTSSPSRPMREQASSVAPTSSSPSPDEVSRCLVHSLFKKRCLAALRSDESQSGKTPDNQTPYYEDEDEENESLTKQLAETAQSVREMNKELGRRIVRSRIQHVLIVTKVNDNRLVSLTRELALYLMQKSPSIPKGTNNRYGTASLTRGMVVYVDSEFESSQAFDVPGLQRDHPELFEPMISNRSFSSLSSVNTPNDSYTDEGPINSGSVTPVGEGQLRYWTNELCSSSPHLFDLVITLGGDGTVLYASWLFQRIVPPVLPFALGSLGFLTKFNFKDYKEIIEKVILDGIRVSLRMRFCCTVYRACTPSDIGCAQANKRRVIKGGCASALKKRVHKSGWESLEDEEVDTHLSDGGSDEEAILHHSTRPEEQFEVLNELVVDRGPNSAMSSLELFGDEYHLTTVQADGLTVSTPTGSTAYSLSAGGSLTSPQTSNILITPICPHTLSFRPVVLEDSIDIRVCVPFDSRTTAWTSFDGRSRLELKQGDHIKVTASKYPFPIILYADKSFPDWASSLSRKLRWNERERQKPYVLVEEARHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS21</accession>
    <name>A0ABR3BS21_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613943.1">
        <property type="nucleotide sequence ID" value="XM_066757559.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989913"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="35902" checksum="974D195F4CE65DCC" modified="2025-10-08" version="1">MPLTVNEPHPQRIKRHYTVRKSPYLVSLVLLLAATSLTLLNIYVPRLIHVKGRTPGPTTFETRYGLYKRCTRSLAVPNSTLAFLESSHPLPIGVELPLVDIFGIEGPTGDPSEGAGNQWVCQNFPTRSECQQFGEKFCVLWSTSGYAAQLSLVPCLASLISLLFIFLHRGERTARAKARRQQWKLVSGTMLIHCLLQVLSIALILHVFRTDARFESKGSHLDHSFNFGVASAVVSLIQALLLTFTGLAARAGKPWAAGQSALKSSNHRRTHSGRVVVVPKGTPVPPHEAVTVGEVRDVQEAGEANERTGLLDGYEGNVAGGGSQRATNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSC2</accession>
    <name>A0ABR3BSC2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614044.1">
        <property type="nucleotide sequence ID" value="XM_066757660.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990016"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0249857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="102" mass="11386" checksum="27B5957DF2D99F26" modified="2025-10-08" version="1">MPWYPGKNGLRAGVLEYMKVLERLKNQSDCTPSSFPFYGPFLRAWVYSPSAKLIRRKVCPGARSFASISCEDSRNEGVLRPHCGGMTQMLSESACGKYTLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSG9</accession>
    <name>A0ABR3BSG9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VPS10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614091.1">
        <property type="nucleotide sequence ID" value="XM_066757707.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990063"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1390"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1433"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="6">
        <location>
            <begin position="69"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="6">
        <location>
            <begin position="749"/>
            <end position="1383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0249904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1495" mass="166892" checksum="01C9558094E1116D" modified="2025-10-08" version="1">MAISPRQCSSLSLLHRPTLKTTWTMLLLFIITVISSVAPLSVLAGDPEVSVSRIENLPNRLFYFDDTPVVMYHDPVRLTVHRSADEGKTWEQVSGPQEGDAARLIEHPHNNEMAFIIGRYSVHWVTYNRGASWQSFETPRDASLTGKTLSFHAENDEWILFQGVACENTGFGKWGGKTCWDETYYTTDAFRSEPQLLLSQTSQCLFARSSKAFKSAPESLIFCVAFDQSQKPGSGGMHSYKESRLFSSEDWFATKKFVNLGIGKRARGVVGLGVVSKFMVVALRAEGTTTKRASGGDPMSLYVTTDGLEWRQTQFPHSALPDLKENAYTVVESTTHSIAVDILTSPSANIGTLFVSSSEGTYFVEALADTNRNEFGIVDFEQLVGLEGVGIANIVSNREQVVGWGEAKKIKSKITYDDGSSWRYLKAPDKKMNGDDWACDISDLESCSLHVHSVTVPHNIGRVFSSTAPGFVMAVGSVGNSLLPYEDCDTFLSTDAGLTWRMVQEGAHKYEFGDQGSILVVVDDEQATDHVHYSYDGGNSWIQLDLGVTIRGIVLTTIPDSTSQKFLLLGTLPRKDSNGGRHAMVFLDFAPLQTRRCKDSDFERWYARSADSKECLMGHRQWYQRRKLDAQCYVGHKFEDPVGHEENCACTDDDYECDYNYVKQDGECVAVGPETVPAGTCSKEGDKYLGSPGYRKIPGNTCENRSGQAKDSPILKDCSLARPESGKPSHVIHEFTSDITSHSYFPLSQTILLQLADSTVWQSSNEGFSWKQLFQDETFLGVVIHEHSPERAYLLTTSRTIYYTTDTGRSWNTISAPADPNNLGIAILDFHPTKADWLIFTGAVDCKDPLSSTCRAVAYYSTNHGRGWKKIDEYVRTCTWARDKRLKIDEREIICESYKNKKGSQVSGEYNPMELIAGANYYSKKIKLFDAVVGFASFSEYLLVAQLHEATGTLSLQVSLDGYNFAEGQFPPNMKIDNHAYTILESSTGSVFLHMTMNSAANNEWGSIFKSNSNGTYYGLSVEYVNRNAAGYVDFEKMIGLDGIAVINIVANPSEADISGRKRLQTRITHNDGGSWKPLNPPAKDSLGQEYDCQWTSCSLQIHGYTERRDPKATYSSPSAVGLMLAVGNVGEELAAYTDSDIFLTRDGGYTWEEVHKDAHMWEFGDSGSIIVLVNDEEPTDHVLYSTDEGLTWSEYPFGQTLRVRTIQTVPDDTSRRFFLIGTNPSSSDKTVLVHLDFSAITQTKCVLSIEDPNHDDFELWSPSESREDKCLFGRQTMYHRRIREKNCYIGERVEQPRTIVRNCTCTPSDFECEFNYRRDSSGKCVLVDGATPLSSDTEEEQCDGYTEFWYERTEYRKIPYSSCEGGERPDLGKRHQCPGLIIGGVRRGALFWGSIAILPFAFAGLAGYWWLKKGDRAGSIRLGDHRAFGGDSTSGVLAVIASVPMFLIAIGQEGWAWVTRRVPFMEDLFTRRSSSYRSVPVDEDAEILGNYDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSL9</accession>
    <name>A0ABR3BSL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613290.1">
        <property type="nucleotide sequence ID" value="XM_066758842.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991221"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="10"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="257" mass="29741" checksum="A2C25B5DAE0C8399" modified="2025-10-08" version="1">MADYRAILDEEFEVLDSIFPEETEKISDTSLSICIEPEEPNSTHPLTLNLIFEYPETYPDVLPELTIEAVDEESGDLTEEEREKVLGELNTIAEESLGMAMSFTIASAAREALGVVISERLRKEKEEDDRRAREYEEAEAAKTRGTPLTPDAFNVWRKAFTAELAAKREKAEEDRIRALPPKEREDYKKRRERPTGKQLFEHSKILATSDEALYEEGAEEVDFSKYTREEREKERRREEEEEEKRRRGLVEGDSDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSP2</accession>
    <name>A0ABR3BSP2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613981.1">
        <property type="nucleotide sequence ID" value="XM_066757597.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989952"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="969"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1341" mass="143158" checksum="DEF94618C47F1EF5" modified="2025-10-08" version="1">MASPPHENDGERPQSIAALRTKFESLAVAGGHAAPSEALQATDEHAAVSSIRNGLLSPRPETGVDGRKAKPAPPPKPASRPVSPAPRQAPSRPTTPKPSFQTHPSTASVTSVVSAGSDSRLKPSDTVSSSPTAISPALAPAAAPLPRSAPSVPSKPPSVAVTPSGSDGDEDEPVATSVKALREKFSGQAQTGEVASRKPVDVPTTAPVPVVKAAPLHDSPVSSLGPSPAPIPPPVIQRTLDGKTSPVMLSPTSEGEMPLHTNDYSSHPSAPPPPPISRKPSPAPASAPTPAPAPTLAPAPVVSGPPPINRAHKPPPRTTASPAPIFRPGSNVPTPNTTPPIPGNKPIIPPRSSSAPEPTAPPPPPERPQPPQLPVRRPTISSPETLEPSTASVVSPPALASTPLLHTIHDNTAPVPAPAPATAAATSPATAPPPLPLRSRANTVSRSESESSATTAGPPPPPLPARHASAAPAAAGSTSSSANGSGSTTMNPPPPPPPAHPASPSKTRSNSGGPPPPLLRSATLNRGSSAGSGNGSVGVGVGGGSPPRRSNTITRTGSITQEKYSASAASLSLGEKEVYSDEDDEPEEPGTVTNLSAQAKRMLDEYPDMTEANRRPPAFVPDIRIKECHHVSAFAVHGRYVCTGAHHVRVYDTQLSDHAISVVDLKETELESRGKDPKVTAMCFRPGATEKEEGRYLWCGTKDGHLWELDISTGEVTSTKPFVHTSSISYIWRHRKNIISLDEGGKLLVFDVGDVEGRPPTMARSLRIGDKFGFAKFLCGKLWTSSGPLTRSTTSSATSKGPTVRIYDPCSPGQMPPPKTIFASEWAGAVTSATHMPLHRDTIFLGHEGGFISVWDGKELVCKQVLKISSTDVLALEGVGEYLWTGNRKGQIHVFDVKEQPWLATNIWIGHPDNPVQSLVVDPYSIQAAGRYTCWSFARDAVRAWDGLLSVDWIDKQLTARQSSFCTFRSVNVLICTWNIDSAKPTDLNGSVANAHFLEDVLKSVDSPDIIVFGFQEVIPLTDKKYTAKTLLFGNKSKDGGASADKISHAYRHWLEKLQSAVKMAFPSDCPYVKIHSESLVGLFTCIFVKQSQKDFLRDLDITTVKRGIGGIYGNKGAIVSRFVIDDTSICFINVHLAAGQSQKASRNADLAGILEDKAIFPPADELPFVHGGCGTGILDHEMVFLNGDLNYRIDQRRENVISSIANGELAYLLEHDQLRKEMRTNHAFRLRNFAEAPITFAPTYKYDPGTHDYDSSEKRRIPAWCDRILYKKSPRINALNYQRYEPTVSDHRPVSAGYTVTLKAIDSLKMMDVRREVAGEWAEREKELLEKMQEVFDGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSP9</accession>
    <name>A0ABR3BSP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613843.1">
        <property type="nucleotide sequence ID" value="XM_066758441.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990816"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="197" mass="22752" checksum="23F51E07DBF9E21E" modified="2025-10-08" version="1">MERSTTQKRPSTIAEESSHDGRHRVEVGQLEQQLEQQREGWSKGWIKGWTKGLTKMLHKSLTSMSMVLQLLTGFLYSIGHTFKDFFTRGFKWLWHWVEVLVEDFSDLYLSLVNAITVIAYGRARQQGQADNNPANQRNRPRYLMFVWLMNIVLTITSAVYQILIDNSQGHEVKMQVCAHSASIAVTHWIASNFIPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT17</accession>
    <name>A0ABR3BT17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614285.1">
        <property type="nucleotide sequence ID" value="XM_066757901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990260"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="64865" checksum="D6B32DF5FD180570" modified="2025-10-08" version="1">MSSTNTHPEAGISYTTPTKKAVFTSSAEAGPSRPRPSGASPAYSSRRHSLYGIEDRVVLDLGSRIWKVGFSGEPEPRAVFLSQDPHDKHSASEAWDLDMESVHGIHGSRSEGGRLIGVRILQKLRETFIKHLLADSKQRKVIIAENTFLPTYIKEHIAHALFDNLRVPSVAFTPSSLLALAACGRITGLVVDVGWLETTITPVYNSRPLFPLSRSTPLAGRRLHTRLRSLLFHHAIYIAPPKSLGDLSREKRRGVPLDLLTDTLIERVITEGLLVGGVLNKPGGDADVEMEVEFNDYTQDNIPRGKRKLEDSRLIDSLRLRFASTSASKDMTFPVHTVKGSIQMGHDTIIVPGWIRERAAEVLFHDDEEDEGESIVNALLNTILKLPVDLRPSLISSVLITGGSASLPGFIPRLRVSLLRSLLAPPQPFDDTPVPPSPLNTPASRKEQASLWKRRTQEPYRELYGLVDKVGILNDPAPLDGEVDGGNGGNAPRWVPGLMTWVGGSLAGVLRTGGPELTRETYDTLLATSLARGDAYRQELEEAYHDVAASIGINVEELKAGEAVRDGRGLGRRRGWKDGRGVVGDWSRAVKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT97</accession>
    <name>A0ABR3BT97_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614372.1">
        <property type="nucleotide sequence ID" value="XM_066757988.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990349"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="99"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="564" mass="63132" checksum="B347CCDFBBB7DC34" modified="2025-10-08" version="1">MSTNPAVPKEVPPDVDRSSTSTVRGEAFNPVANHEKLKNDPAGMDKNIRKQETQITHVEGQTRPRQRRGDTGDGQHILQEEEAPEVLGFAWSTRKKWTTLTVIFIVQCSMNYNAAVYANGTAFLQEKFDISAQAARVGQMIFLVSYAFGCEAWAPWSEELGRRWILQSSLFLVNIWQILAALAPNFGSVIVARFLGGISSAGGSVTLGMVADLYDPNEQQWAVAFIVFSSVGGSVIGPIVGPFIAANLDWGWICWTQLIFGGFVQILHLLIVPESRATILLDREAKRRREAGEHNIYGPNELKSFKERFSLHEMIKTFCRPFVMFVTEPIVLCLSLLSGFSDALIFTFMEAFTPVYEQWGFDTEHMALAFVPIAIGYFLAYLIYIPPLMKQRKVLRKDPDAAPELRLKPLLYLAPLETIGLFGFAWTSLGPPHVHWIAPMIFSCLVGIANYAIYMSTIDYMVAAYGPYSASATGGNGMARDFLAGIAALYATPFYTNIGGSSYRLHLEWPSTILAIIAFFVAIPIYVFYYYGAWFRERSKFAMSLAGERIERRVSRLEEQKMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTF2</accession>
    <name>A0ABR3BTF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_102403</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614417.1">
        <property type="nucleotide sequence ID" value="XM_066756948.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989260"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="11">
        <location>
            <begin position="954"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="302"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="573"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="892"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1104"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="650"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="699"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="734"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="788"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="818"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="894"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="920"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0250230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1872" mass="197789" checksum="EF301AE921BDB622" modified="2025-10-08" version="1">MFGSTSSWGQNNQNQQQQQGGGLFGGGGGGGFGQQNTGGFGQTGTTGGFGQPAQNTGSVFGGGAATNTGFGGFGANSQQQQAQQSNAFGAARPAFGAAGSTFGQNTTGGGLFGSSNTANTGFGSNTSNTTGGGLFGAKPATATFGSGATSNLFGAKPSTGFGASTGTQEVLKGPSELQTYRTDIPPPPPPSTGTANPIYYPTWQADPSTNTALGKEGPPHLFHSITAMLPYRGCSWEELRALDYQQGRKEASPQQQNAFGASSTGGFGQPASTGFGQQPATTGFGAKPAGTGLFGSSSPVTGFGTTPNTSTGFGASNTNTGGGLFGQSQPQQGSSLFGQTNTNTGGGLFGQTQPPQNTGGGLFGSNTTTTTPFGGAQTTQQPPATSTFGGFGQSKPAFGSTGTTGFGTGSTGTSTFGQTGTGTTGFGGFGQTQPQQQQQQQQPATGGGLFGGGGFGATNTQQQAPSTGLFGQTAQQQQPATTGFGAKPGGLFGSTTAPASTSTGFGGFGQTSSSQPAGAGLFGSTGTNTNTTGGGLFGQTQPQQTAQQPATGGGLFGNVGTAPATGGGLFGAKPATTTAPSTGLFGQTQPIQQPAQTGGGLFGTTTSTTGGGLFGGTANTSLGQLGQQNQPSGGGLFGAKPATGGGLFGGASTTGTGTGLFGQQPQQQQQQQQQQQQQQQQQQQQQPQTGTTGGLFGNLGQSQPASTGLFGSTATQPPQQSTFGGGGLFGGLGQSTVQQPQQQQQQLQPSLTASIDQNPYGNNPLFAYSGQKLEVGSQSKRPALPPLTASSYRLTPSTNKSKINKLRGFASPLNVSQSPGRSGSPLSVSSPGRSSLFNSPAAPDRYKGLSDTALTPNAFVPRPNIKKLSVTPNIGSSIGNSDQLESVLGKSALKASTSSVKGASSPKTPGTPLVFHPPVNGTSSRPEIADSSVTRSTSAIASPRVAGSERAPKEGDYWCRPKLEKLEQMSKEDLSQLSGFTAGRRGFGEVSFLEPVDLTLAPLEDILGSIIVVDQSELSVYPDDYPQKPEMGQGLNVPARIMLENVFTTDKATKDWVRDPEDPRFQKFVRRVKAIPDTEFISYTDDGTWTFRVEHFTTYGIADSDEDESVENEDLKRRRNGAASDFSRSPSRTSAEDDDDEMFPPTKSIRDVEAEHDSAFEEDQLSEESYMEDGLTEANESVEMDFPQASWDLPIKTQLGAEGMKNLRGMQDSFFGSSASMARPGKELALSKKREAEKGYGSFFREAEEENVKLDEQVIKRTSFGETQISLPKLRQPRKYARVIEEQSVAKGAEGLKMDAGLALGRSFRCSWGPNGELVHFGKICSPTASIRADTDATVHIEKVEVLSEETKVETAKSQRLLSLHLETSLIEQVEGVPIATINPGIRFHDFASRFDTGDRSHEANVFRLGVALFDEIDVQLPEGSSEELIERISSIRRKLALSKWLEDVVAPLVDFDVITRSEDRPGKIFSLLSGHQVERAVESALEAGDMRLATLLSQAGGEESFKDELLKQLEGWQVYKVNPLIAVGYRKLYALLAGITDVSAGDPSRGSDGCPDVLIAEGLDWKRVFGLHLWYGIPFENTIRDVVDSYTFSLSSSHPPAKPLPPYLEKSSDDARSWNLPTEPTDVLYNLLQLYSDDAISLDQVLRSRDTSPSPFDVRLAWHLYVLLSRVLRRRDFEDRDESNGYSANADRLTAGYAAQLEQIGEWKWAAFVLLHLETVDGRSKALHALLYRHPDATKEDQAFLTETLRIPEEWIYESRAASLCSIDDAWGEYHALLQAKLYDRAHKILVEKLAPEAVLRDDKVLLRRLCSKLESKGVSGWEYGGKLFLEWADASEDTVSLPPSIVFSGAIADSRKAVLRQFDQMISEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTL8</accession>
    <name>A0ABR3BTL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pheromone-processing carboxypeptidase KEX1</fullName>
            <ecNumber evidence="14">3.4.16.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Carboxypeptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Pheromone-processing carboxypeptidase kex1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">I308_103462</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IND107</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.6" evidence="14"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614341.1">
        <property type="nucleotide sequence ID" value="XM_066757957.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990318"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 20" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="590"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAL0250154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="667" mass="74096" checksum="D9821E4A9734B373" modified="2025-10-08" version="1">MSGNDARARVRSLSSTSSPLETRDSDEQEPSSSQSQHGSRRRGPQRRATELPSAADLYVPSLPGLPDMATHPTHPLNIYAGMLPSYPGEGKGGGEGETGKDAKLYFLMAKARRNAGKERVIFWFNGGPGCSSFDGSLMEVGPFRTVPASETTTGMVEARLVEGGWEEFATVVFVDQPPGTGYSYAATNGYLHDFDELAAHFIEFLRNFYTVFPELKGVDTYLAGESFAGQYIPFFADALINSTELPNFPLKGIAIGNGWIDPKEQYPGYVEFAYEKGLIDSGTPEAEEMEAALKRCQEEMDKYTDPFTTPVNIDHCGEVMDSVTRPFTQELNGKKVCMNVYDVRLVDDFPACGMNWPPDLPDVYTFLRQDEVISALHASSKETAWVECNNKVSYELNLKHSHMSAALLPSILEAGVPILMFAGAEDLICNYKGIERIVNGLEWDGEKGFTNATSQEWYLNGTQVGTWETSRGLSYAKIFDSSHMVGFDVPHVTNDMIMRFMDVDVSLLPGMISQWSSRIGDDERTMIHVGDAGEAGGVPLIKGGNTDWEAWYNAVFAFLVLGILVSIVGLYFYFHRKPVSYRSRIALKQRGRHRRSHDRDEGDTAERMPLGSERLELDDIERAEGYEFDDRDGEGYSGKGKGKGKELADDREEVMFALGDDDEDDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTS5</accession>
    <name>A0ABR3BTS5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614543.1">
        <property type="nucleotide sequence ID" value="XM_066757074.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989386"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="335"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="629" mass="71047" checksum="D7C73B1378F55E81" modified="2025-10-08" version="1">MPRYLRIYVAVAAFALLAAVHYLLPPSPGTEPYFASSSPGVFDGEDGQRADSAGVVVDKKGLMSYSPGHAGHPVEMLIERAKKLADDMERRIASVKSVKDSAKDYVLSFGMRPPRGFDAWYAYTQSAPAPHPPPLPSLIPLAHKPMLPFLSHPAALLRTRVGELRDNDGSIFTLTFVTDGQGDRGTACAANGKWHTKDWHVRDKGMVLVRGAAAWSWRCNNTLSLLLPLLPLMPEEMFSQNPPLELAFSIDDGPRGMVHNTFRERSETLARSGRLWPEAQLHQAEQAMRWTYGWSWSCPENTPLKGHGSDLVINDLTDIVSADAESQHVAGDKTFIADFDKSIDYCMNPDLMSLHHILLSEQYRAAVDLVPALATCRTKWNSDLVGVPLDGVHETVEFIPWEKKEINKAFWRGTATGLFHDKVNAWRQSQRERLHWFGNNMTGTMPLLLPDGSIKHWDRADLVDKWSDVGLSGGPTQCNVEDGTCDAMAKEIDFKDRVSKEDGIKYKYVIDVDGNGWSSRFRRLLQGNNVVFKSTLYPEWFHDMLIPWYHYIPTKLDYSDIFDILAFFQGSPDGSIPGRDDLAKEIAAHAHEFVQERWREEDMRSFMYLLILEYWRLMSDDRKAASYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTW1</accession>
    <name>A0ABR3BTW1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614564.1">
        <property type="nucleotide sequence ID" value="XM_066757095.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989407"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="760"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="882"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="954"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1306"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="351"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1170"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1393" mass="154164" checksum="41B3155318459364" modified="2025-10-08" version="1">MGVPNYKHYETYETPHSSTDFDISSRTHTLATSRPPPIGNTDPTSNTDPTSNTDPTSNTDPTSNTDPTSNTDPTSNTDPTSNTDPTSNTDSTSEFMYQMPAMQGFGKSMSERGNFTCYGPLDLNALNERLQGLGLKLDERFESLENSNIANQSRSPKANGQSQPYSPNGYERSLNQANQLPQAPLTKQAPTTNPPIIHTGYPSTPLLDPNEPDSNQPYRWAYPSVTELAPDDSVSMYRPARAPSTVRSSRSGGTNVDPGENANIPGEMYDEIHEQQDGETFWSHDNITQGTPKTSRRFEEEMTVGATSVWTWGDIGRDMYDMRDRLLDAETRRDKKAMTTLRRQISDAQEFAATTARLDAAERQLRELQAKLIAEQIARTQIEQEAGLREDEVKNYQNEWASSVRALRRAREEGKKTDEEKRRIQRCFEEARDKLWRYHEALRVREARAQGKEEGRAEAWQEVERWMGGSPPIPGVDPIPAVPGAVLHQTPTTGPLYLQSPQLQSPTANLFQQQQQQQQQQQQQQQQQQQQQQQQQQQQPLPPQQPISPAQQLPMQSIAQLLGWLANNPETFPQALGNQGQLHDHQNIHPQQVQVQGMGVLPQQQFTVQHDGAAARYVGKAAMSPQIQQMPSQAHHHHHQQQPAMVTMMMPMTQFQPVGQSSQAQQQLPQQIYHIPGTQQHSLPRQPTSTRSQGERLPGNIPNAQTDRSSHGNALMTDPVLNPPTADSYLERVDHDPELKMMMAATRSKTVHTSQVPTAVTTELENGRQPPAATKSQFEDNRSNVHKPLPPLKLDIPGVTRSHTVRAAPTDSVSNNRQFKRMSLSEGLHNYDYHQRPMNQIPEGDRYPIFPLPGQNRQNGFGTVGPTSINHVAPLEVSNCQSPNSEYRGGRASEWSTPARCNRGPATSSARSKVASALRKDMNIEPELENIEEIHERETFTDRHAGQVPAPMEQHGETGMPPHMHFQGGRGPSGPPRPAPSMPNMRHRIQPVMPKPLVHSWDRSESHPGVGRPQSHSITALYNACQMEDPIIPSHLATAAVSSGVENVQGRQSALGLSGVGGDDKGSDGIEGMDMGRMRAPTITVQPPSSRSPSNNPNIAANPSQVSAHSQISPTTFQPPDPFAAPNGNRDGTHSRRVPIGLNTAPIQKGHSNSVDILPSPSVLSSGAKNHSHRIPSFHHRSNSRHPEPREIQPPSSGSDAQAAHTRARNSHSHTPSQPHLPPIVVPAKNHAYQSHQADEAPLPTSRSVAPTVHRRMPHNTLTSIDTLKNELRKIEFAKEIQLPSRMETIYDTRTTVVTEEDIDQPAFPQPTFSRQPRRRPIASNLGKVNGGNGSSGRGNRVDPRSYVRPLSRPTMKKASTYAASVPPIEEATEPESGRDTARRSRISGTIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU67</accession>
    <name>A0ABR3BU67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613533.1">
        <property type="nucleotide sequence ID" value="XM_066758131.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990500"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="222"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="532" mass="60729" checksum="E66BE4B60A495733" modified="2025-10-08" version="1">MSDLENELLGLAEDDPTRHRKRHGSNDRSKRKSKAFIEESDDDGEEEDMEMESEDDEPAPQRSRGPLRNPYPLEGKYVDEADREALENLPEIERENILASRLEEMQKFKDSQALDAMFKTAHGGDDEDEDDSRARKRRKHTSVSEKASRALNVLKNKRKAKDERMQRRAARRRHSRSASASSEEEGQITRRSPSYSPERSLSPQPKDTQPKLSKEEEMDAIAPNRAELESARVSRYELVDMMHKDGFEDIITGAYVRIISPDRDEHGRPKYRLYKIADVDDSGQFGSYSIEYQGRQIRESRALLVKYGSASRLFRMADVSNGVIEESEFQRFSMTNQADGVKTPKRSFLKKKHDEIKALRERPMTSAEIDRRVDSRKSQESSFNRASLLKIHQLMNTRDLALRRNDHTMVEKLNSDIIALGGDPNTGKLIGEKEGEEKDDYDMKIQRINENNKRKTKEAMMRAHAAAVARKKAEEAVIKAKLAASQNPSQTNTPATDVPKPDVPPPSGQRKGETPQQYVARTVQLDLDLGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU71</accession>
    <name>A0ABR3BU71_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614675.1">
        <property type="nucleotide sequence ID" value="XM_066757206.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989522"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="52"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="516" mass="56477" checksum="74CE6DE086A6BF2A" modified="2025-10-08" version="1">MSPLARIQLLPRMSRPVATSRLAVLNRHLSSSSQMAAPREELVLFESQQDTRIYKLNRSAKLNSLNHEMIDSLSNKIKAWRELDSCKVIIGTGDSRAFCAGGDVKQLVLDLKEGKQTAVPFFKSEFQLNWSLARLGKPYVAVIDGVTMGGGGGISLPAHIRIATPRTIFAMPETKIGYSPDVGSNYYFAQLDGFIGAWLAVTGQEVYGRAAYELGIATHYVTQNNISDIIYQIAQHPSPTPANISSLISSYTAPASTTSAVSSKSSPDGPTPIKGEIRKFLDKTFNKKSIQEIYAALDKSQSDDKLSSEVKEWAAQQKLQMEARSPTGMAVALQNYRKARETRRLDRTLLNDISMATAYTGANRATDDFITGVSAVLIDRSKGPVAWAPKGINEESLSPQNINSRFFSASSPHVADKPEIEFIPSSASKLDSGRDSTWGQFRKYGLPSEEAVRAAVDGYAPGSGAFALLEEELIEQFIDAQSDVQGTRRDEVVKRVKEVVSTCCKKGKDGYLEWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU72</accession>
    <name>A0ABR3BU72_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_102396</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614410.1">
        <property type="nucleotide sequence ID" value="XM_066756941.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989253"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0250223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="332" mass="37449" checksum="10B4100040BFFFA3" modified="2025-10-08" version="1">MAAASNSAPLDPKLGRAADFVRPDFHQVNLDLENYLKTERNFKLDADQQICPLSITPLGCPLPPSQCPYRHTTPSQLNFKPPPPLPAHPREREKKLTVCKHYLRNLCKMGDNCEYTHDFNLRTMPECIWFVKQGKCELGGECLYFHPRDRRVECPDYNRGFCVLGPNCPRKHIRRRLCEAYAAGFCPDGRDCKLAHPFPNRPPPESYINPIPPDPEAFNGPPPQLPAGYGRWREYKYDPNAVVVPAAAWVEGGSLSGWRAGGFLSANARRDNQRNRDNDDEGGRGGGGERKGGWQKDLSTVLCFRCNQYGHFANNCPNQYVPGDRGGGRRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU94</accession>
    <name>A0ABR3BU94_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614692.1">
        <property type="nucleotide sequence ID" value="XM_066757223.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989539"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="335" mass="37367" checksum="DA85BFBD826E8651" modified="2025-10-08" version="1">MKINFPPPRNELSNVDVEIACLNRTLFSPIFSPPITLTQKYTPHMTPIRTSRFSKLTPVLSISREDPYKRENAKLGGKWGWGRYNRLDKNEETPLIRRESGVSGRSSDSDRTLVGATANCGENICLVQDEWVHDPAGELLVLLAPVISTIQRMGIKISSHVHALLPAEYDVLRDHYLEACNAMLSALNKLQSPQSYVKARRSSFVDTEDDLEMRTLILEALIKKIKAEQARFRFLPTTLTSSHNPFVVHAAASLQNPDQRPSGRRASTVQFNPIKIVPAQVTLPNGEISSRSFIRSPQQSSWAMNIVRLGSFQASALFTPSPIAVRKPVEDAGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUI9</accession>
    <name>A0ABR3BUI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1776-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614794.1">
        <property type="nucleotide sequence ID" value="XM_066757325.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989646"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="58397" checksum="80AF89D43E64F113" modified="2025-10-08" version="1">MPEDLSFLDQLEDWLEAQIPNNLHDLPSKMFDTVEKLTNDIFETLNVHGPPSISIPFPPFGGKEVPHAPPPPPPLPNSTISCCQDMVHRSGRFVKTHPIAVGAAISVGLGFTGLVAYHAGGFFAKGRKERRQFGVNGVVRDGMLKEAIVILAPSPMPPILVPLAATLLRSGYIVLIAVTNNRDAQSLEKRLNGLEERSALRVLVYDPDDPSTFPPFHRSLLATLTLRFPVNGRYTAGDPYNPQPSQLAHIHAFLSLYPLHPSPPSQPGALPALPTLLAPNPDGSKPMLVNFYPSGSVPTTPITFASQILSSNHVLLGRNLAASSGARIVSIYVGDVDLPTLPAILSHGRTLSRRQIAKERLAQVASPQQKVSIIRDYIYGSFNAVFSAVIGTLGLGTAVRDYKTFEKGVLRAIKSSHGRLFFIGQRSFLPFFVAHLPIPSPFLPPLLAYLPAMPSCTGPVASEPVKSAGYKNKTSMAKQGDTSRQDPNGEKERLSASEGSEHEAGEDLVSSVHTGTSTSSRGVCSESSEGASGLGGSWVGLEDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUM1</accession>
    <name>A0ABR3BUM1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614825.1">
        <property type="nucleotide sequence ID" value="XM_066757356.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989677"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="100" mass="10423" checksum="D0F06A0414C0AE26" modified="2025-10-08" version="1">MTRNSLPPIQTRLDAISAPPNVPQRTHKKGASSDSSHRGSPSVDASDGRNDQPAGSAFGLETPQVTTPEMTSPDTSMIAVHGSALGSPFSPGMAKRSRHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV24</accession>
    <name>A0ABR3BV24_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614710.1">
        <property type="nucleotide sequence ID" value="XM_066757241.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989557"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="39639" checksum="8488305609008FCF" modified="2025-10-08" version="1">MTHPGCVLCGLVRSCGSNPSSPALPPQGSTTPLPSSSRAPSLAASFADSGAHLPYHHPFERTQSPAPEGWRTGSRVGGREVVYHDKDITVYKAEGNERLCQDGRHIIVVVNEHLQSVYEFGASDIPLLSHVLDTAAQILNSAAATAGNDVERGTGKEKLQVGFVGSIIKDPQSPHAHLHAHAYLPPIDTKLSGASLWRRNVIFGSLNWWSIEDLRAEIRQATSNNRVKTGYEYRQAPIDKVPDAGAAIASANALDPTYSDTPSSQSNQHALQQQQQRQQQEAGPSSNRSQRGPSSVSTDRRSPQPTYPLSQINSRGSVVPVNHVTSQTSDPDKMSRESKGKGKEKDINDREDAQLGSKGAERSPDGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVA0</accession>
    <name>A0ABR3BVA0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615022.1">
        <property type="nucleotide sequence ID" value="XM_066756245.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988549"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15461" checksum="3133D12DF7D034E9" modified="2025-10-08" version="1">MSSSLSQSPDPESPIAIPAQSRIQPAQKIKGRKGKAGGTGKKGKVFVEDKKDLLSLMSSITSNKDSVRAEKVAKAKAHIEKGDGRMEKKNDGSLRKRQEKQKALEAAKAKLVEKQREKKRRRQGKEVIEEKPAKKRVGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVA9</accession>
    <name>A0ABR3BVA9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613938.1">
        <property type="nucleotide sequence ID" value="XM_066757554.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989908"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF2">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045438685" evidence="1">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="237" mass="26598" checksum="DDB86F1BE4373580" modified="2025-10-08" version="1">MVFGLLTAIAACPAIIGTTEAIQQGQKANAREQHRGRKTNLTIKLPGAHSYKPKFEGCMVVLHDKKLYVDHANCESLAYSHPFQGYYLPHPQNQSRWKGAGWKGEGMVTTINEDNMLNWVYVDANTYELKHGVRAEAQDHLTGPWDCTQIDRRVTFEGWEGFVLVQEDEEKDLWALYFDKDDDGLAGEGKIGDVEANGGKRRRMLEVQLREDTSVTGEDEGAAGMILKRPCTYTYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVR8</accession>
    <name>A0ABR3BVR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM5</name>
        <name evidence="11" type="ORF">I308_102994</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614965.1">
        <property type="nucleotide sequence ID" value="XM_066757496.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989850"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="84" mass="9122" checksum="B4C8AEA7C69F60B4" modified="2025-10-08" version="1">MASTILPLELVDRCIGSPIWVLMKNEREFTGTLMGFDDYVNMVLKDVKEYEVTASGTTETDLGDTLLNGNNIAMLIPGGKGPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVU1</accession>
    <name>A0ABR3BVU1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell differentiation protein rcd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615223.1">
        <property type="nucleotide sequence ID" value="XM_066756446.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988753"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="443" mass="48382" checksum="89BE51D831A8851D" modified="2025-10-08" version="1">MFSHAPPHLSHQHQHHPLQHQSLHRPPTAPSTPDTEHSTHTWAPTPSFPQHMNQQLQPGSNIPPYLFDRRQFPYSAPSADATRQNAAHTPQLAATQSTTPGASASGPLLPQNLAQHLNNPPPPTGSQQSINPAMQTQAGPGAGTIAGASAGGKVLLMPNGAPPPAGSDEEKIYILITELLEPETREAALLELSKKRELYEDLALVLWGGFGIMSSLLLEIVAVYPALSPPSLTAHASNRVCNALALLQCVASHSDTRALFLNAHIPLFLYPFLNTTSKTRPFEYLRLTSLGVIGALVKQNDNSDVINFLLSTEIIPLCLRIMETGSELSKTVAIFIVQKILADDLGLQYICQTYERFYAVGTVLANMVDALVESQAVRLLKHVVRCYLRMSDNPRAREALRACLPKALQDNTFNPLLKGDMVTKRCLQTLLMNLNERPASDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVY2</accession>
    <name>A0ABR3BVY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydantoinase B/oxoprolinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615272.1">
        <property type="nucleotide sequence ID" value="XM_066756495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988802"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="581" mass="62722" checksum="185718E06A30933E" modified="2025-10-08" version="1">MQTTAKSYDPITLSLFSNRFMCIAEAMGRSLKQTAISTNIKERLDFSCAVFSPTGDLVANAPFVPVHLGSMSWSVKYQLKLHGKSLKDGDVLLTNSPLAGGSHLPDLTVITPCFDENDPSKIIFFTASRGHHSDIGGILPGSMPPTSTNINEEGANIQSLKIVSDGQYDHEGLYRVMVEEPSKYPGCSGCRNFRDVESDVKAQIAANNKGSSLLRALVEEYDLKTVHEYMEHIRNNAEQAVRNMLRKAAANAKTNILYGIDYLDDGSPIALKITIDVDSGSAIFDFEGTGPELRGNLNAPICVVHAAVIYCLRSMIGEDIPLNAGCLVPIEIRIPEGSLLSPSPESAVCGGNVMTSQRITDVVLRAFKACAASQGCCNNLTFGAGGKDFETGEMIDGWGYYETIAGGSGAGDGWHGTSGVHCHMTNTRITDPEILERRYPVILREFGLRSNSGGFGQYNGGEGCVRSLQFLQPLQVSILSERRARGPYGMNGGDCGAPGLNLWIKQAHAESAKGKPRVINIGGKGTMQFETGDMIVLHTPGGGGWGKREDTDSKLKQEDEPLQAKKWEARGSWADMAKVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWL4</accession>
    <name>A0ABR3BWL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614990.1">
        <property type="nucleotide sequence ID" value="XM_066756213.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988517"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="264"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="571"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0252270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="705" mass="77563" checksum="5F18A894A1A8ACC8" modified="2025-10-08" version="1">MGGCLHFATRHLFFLPSRQTRQLSQIMGRTTRRSTKSQSGTSTPPNISCPPSRPLFPSISLRSSSPTPPSHENLSARSSLLNVLTRPGHTVAATPDSPEEELSDLSTVSSYASSVISGTRPKDMTEEEIAKVYENYLETPFVQTKTTIKHSEFGHCNNPNWRWTSQWNPNEVIHADDARPSYTVLLSTYLSYILLIIIGHIRDFFGKKFTPASYAHLMPQNKRLDDCFARPTTGVPGRTIVCYDRSSTDQNNTFQLTGTTTRALNVSSYNYLGFASSTGGCADAVEMAIKRYGVASAGARHEASTTDLHLQCEKLVAKFLGVEAAMVVSMGYATNSTTIPALVGKGCLVISDEFNHASIRAGVRMSGASMRWYKHNDMDVLENLLREVISQGQPRTHRPWKKILVIVEGLFSMEGSLVDLPRLIELKKRYKFYLYVDEAHSIGAMGPNGRGVCDYFGIDPREVDVLMGTVTKSFGAAGGYIAGTKQLVDRLRIRSHATAYAESVSPAILTQIIASMGSIMGIAPPLAAPPTEDDKSDTWSIASRPAVYGPAPSSLLPPWLTLPPHLLNGTEGRERLRRIAFNSRYLASGLRKLGFIVYGNRDSPIIPLLIFQPGKMGYFSRMMLERIGPDKTPIVVVVVAYPATPLITSRVRFCLSASHTKNDMDMVLRACDEVGDVLNLKYNKQEMSVEEVIANAEELVAASHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWQ6</accession>
    <name>A0ABR3BWQ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614463.1">
        <property type="nucleotide sequence ID" value="XM_066756994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989306"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="330" mass="35753" checksum="9179D926D7AA54EC" modified="2025-10-08" version="1">MPVTKKKGAVFAIYTDSPDRNSQPLSKQPTRTSPRRSTNTSRKALTSLQPKSLLPPSSKALSLKQSEVLKHKPHSDAPVKSKSKSTIQIYTDPEPSKPKSSGVIGATAIKRRAPTPTLVACQPLPVPPSIKRTRDLLSPLPIFLDSQENEGASCRPTTRSVTGRSPAKRGRTVLSAVESSPAILSSANRRKKEVTMNKENSPPPTLLFDDFEGSPATRTRSKVRNMPFEFSLTLSPLNFRDTQQQRRRTEVERLLGDSPVQGVNATRRDAVEEMINHESPTAEKTGGGKPLAGKTRGKGIAVRSDAILADVSEAYGAKGDAPEGFDSQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWR8</accession>
    <name>A0ABR3BWR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-type H+-transporting ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615542.1">
        <property type="nucleotide sequence ID" value="XM_066756765.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989072"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10573" checksum="749583864C45CCAF" modified="2025-10-08" version="1">MLPTAARRSLAGLIPPKIATPGAVSSGTTSARTAQVIDFYSKLPKGPKPASQKVGGIKGRFFEGKNASGAPILATLGTLFLIGYTIDYNMHLKHHKHGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX14</accession>
    <name>A0ABR3BX14_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615648.1">
        <property type="nucleotide sequence ID" value="XM_066756871.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989179"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="260" mass="29375" checksum="CAEEB2C9BB9B68AD" modified="2025-10-08" version="1">MMSSLQKAPTSDSDSERTLYDCPDRTCPADRADPRHDSRSEIFFPYAPPFFSIVPALTSSTQQPQVTSLQPKEETKWQRPLFLPTLNAHRRLVSLIVALAFLSGGLITGWIVFVIHQNHILPGEESPDNEEKDDDQELNPLILLIDAVFIILREEGEDRSGSGMPGAMAHDEDIERQMRAREQGLMSYEMSEQLQAITQLQRQIQSQPQSFVLEVTVENEPVTVNMEDIKVRRTIETEEGGGNGDEEKEKDDKIEVRLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX16</accession>
    <name>A0ABR3BX16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066756868.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989176"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
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    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
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            <begin position="23"/>
            <end position="55"/>
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            <begin position="57"/>
            <end position="78"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="581"/>
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            <begin position="583"/>
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            <begin position="613"/>
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            <begin position="642"/>
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            <begin position="693"/>
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        <location>
            <begin position="741"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX75</accession>
    <name>A0ABR3BX75_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252985.1"/>
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        <property type="nucleotide sequence ID" value="XM_066756928.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="191"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="295" mass="34413" checksum="A3F7558A664B8D9D" modified="2025-10-08" version="1">MRPTKQVGGLRVTLLDPTRRGYLARYRAFVVPSPPQPGYGLLSRSHRSFQIDPQPLWLPPLLSPPSTLSPETLINPRKTKIPKKERERTHERLLEHKWLLDQEHERRFRRGMAAIMADVLEFQMASATSAKSGTEYTWKGVKLNCVMALQEFFRAIRKDSTAIYAYLGPLEFSLVANRDEVYRMVKEEERKRRKREKKKANKELEKEAEARLNEERERLETERKAEASLNLMEGLGRTIDAIQITLDSEAFISPFPLLAKTCTQEQHDKVARHIAHLPYLREEETVLLRELKIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXI6</accession>
    <name>A0ABR3BXI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614748.1">
        <property type="nucleotide sequence ID" value="XM_066757279.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989596"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46563:SF3">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46563">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="228"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1054" mass="114038" checksum="813E1BCFAB952936" modified="2025-10-08" version="1">MNSQNQQSQLNPSDQSLQARLALLAAQQQNPSDRPPVSQDHIAAMAAAVGSMQGQNRDAIMKQLQALQSSHANRAKLAAQQAINQQPQAGPSAPSPANQQGVSAPSPITVPSPSNSLHQDGFQYPGMPRSGSGDSLINQQQQQQQQQLQQQQLQQQQLQLQPQQQQQEQQIQPLMTQQQRELFLAQRAHQQQSMAGPSDGSVRPPLPTQSNLPGQPQGQSPRQPLSHVQQRQNFLKTFMGYFQNTGQQPAPAIFDNGEREGAFKVGDGWMDVIDLLMAVMKAGGILNAMQQPADSPTWRNLLAAKNIPTTLPHPIPAPKPPNSDPNAPPTMTTDPVQYLSAAYFAYIHGFETHMQKTRQASYARQQAMAIAQGRPPPPPPVMPSLAGVRLPGQAPSPADSWSPASAQAQTPAQTTAPPLPPPAPSIPTSAHPAPSPSDSATSATKPSSSSGPPRARKTSSKKEKKDLAVSTNVPSPVDGEAETPTGSSGGKKRKRKNANASQPETASTPVPPATVSTPASEPPAEPIKRARYRVEYRPINFPVQAFAGWEPSMVSSTFPKHSLGQGTRPIHDLTVVDMEAILMGLRSRMPKELGYAVTVLNMLSMSHPEENINGLPLHHLREIFVELLDLTEEAAFGEEGQNGWLKKWHDLNDVKEESAAAAAPAAADDDDDKNNSYMGNLNKMSFFELERLGRDFDFSICQDEEEYQWRKEETGGNTEIVLACINVLRNFSMLPDNQELMASYPQMINLLASISDARLCRLPGESCNQTNRPFSIIELARIRRDCVSILVNIGEYVELPRVPSSSSLAIFRLLSTFITSGWESNALNEPIYGPTLSSSFRDLGPPTIVPSINRALAAFSLLAQPDANREALGSSVPPSELVDMYESLLKLLPVTKRQFEAMHSIEETLGYNETLALCLYSLVFLSPLPVRASMRNVPGSIPLLTRIIFDTALQKSDYRTNPFGILCRRLCETLGVLNGTVSPAGTVEGPSGMGFGAGGIDGSGWKFASGKVENGWLAGKEEGVLGAILGVKGMSWAALGELDGMVWGGDSISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXQ0</accession>
    <name>A0ABR3BXQ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Solute carrier family 25 (Mitochondrial phosphate transporter), member 23/24/25/41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615041.1">
        <property type="nucleotide sequence ID" value="XM_066756264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988568"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="68"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="170"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="284"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="40972" checksum="C4CEEC22E634A691" modified="2025-10-08" version="1">MSSSTTSNSPQTPEHPTKLHRHSVQDEASEFAVATSSSTYAIAEEEIESESQETTFRGRLRDIMADNQIVINTFIAGGLAGAASRTVVSPLERLKIILQVQATGSKSGAGQAYSGVWESLVRMWKDEGWRGFMKGNGINVVRILPYSALQFTSYGAFKSVLSTWSDQETLSTPLRLTAGAGAGVVAVVATYPLDLVRARLSIATANMAVRQPGAAFTNEDSRLGMVGMTKKVYKAEGGLRGLYRGCWATALGVAPYVSLNFFFYESVKTYVLPGPSSPPISETDLALRKLFCGAVSGASSLIFTHPFDVLRRKLQVAGLSTLTPHYDGAIDAMRQIIRNEGFWKGMYRGLAPNLIKVTPSIAVSFYVFELVRDSLEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ03</accession>
    <name>A0ABR3BZ03_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615843.1">
        <property type="nucleotide sequence ID" value="XM_066755557.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987855"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0253622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="95" mass="10716" checksum="F9417245807AF304" modified="2025-10-08" version="1">MSCRAFPIFTSPSIRLPPSPLIIHSPLLSFSPGPSHILYRNQTELRLGNEFWADAYSRLLKPAVVQLPEEKFEDLEIVQERIQTDEQLLGNGSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C046</accession>
    <name>A0ABR3C046_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616226.1">
        <property type="nucleotide sequence ID" value="XM_066755940.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988242"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0254005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="684" mass="74522" checksum="73057B46543AC30F" modified="2025-10-08" version="1">MLPRPPPKDQFLSANTGYINQDLAEAVRDSVRIKSPDWSNRSYNSYSSAQQFDDPYTHTGTRRTPSPNPPRPINVFQPNKPSYNDLSPEVDNFDDMASDPASAQPALPSARMQQLKNPFEEDEIEPAGTGAIKPPDIRNFALEGNGAVQPRRNKFSRAQTGTTTSSSSTSYLLGSSPSSAQINKARTRRSLSTNSYGLSGDAPSMTALMEGQRKGVDEKKGSRHADVIDTWDPTGLGSAMWHHAGPYDAAAPSRNTNLPTTKAPMKAFQKPESPVAPPRGPSTISLSPPVPPAKDTPRDVLEPDRRRPSRGISTGRRSAGDGLTGQYSTSMPSDGGYFPNIGEEDPQDEATLARIERQRERESKRKALKAAWGIDTPEPFEDYGGTPNDGPIDITDDIYTPESISSPLPSGRTMRSPGFRLGIDPRTPPIKEDSTSPTLESPPPLRAVVTATNVPPGGIKRTKSLMQKIKTMRENPNIPFRGQPRDTRPYSSSRESSPMSSEAPSDDMISPSAGSATAARYPHLFDKGSGRPPSDKRSSFSASQTEPPSSAPIASREEGLIAVAEDDKSRSMAGALEREEIPSMASNGYTIVESPSSKARAIRALQREAEHHTRSASYGATPSPRRATAAPPVAPVLPDFDDYWYRREKVRFNSDTLDSGDLKEVKELKRKTSMVKKLRDRIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C048</accession>
    <name>A0ABR3C048_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615614.1">
        <property type="nucleotide sequence ID" value="XM_066756837.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989144"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="70" mass="7689" checksum="321CA2F2191B2380" modified="2025-10-08" version="1">MTANPPTQCPSAALRIAGDCPHCQRVFCSTHRTPESHNCTGMQACRDAAFQANKEKLEREKTVNSKIAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C169</accession>
    <name>A0ABR3C169_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615742.1">
        <property type="nucleotide sequence ID" value="XM_066755456.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987751"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05238">
        <property type="entry name" value="Gne_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="347" mass="37463" checksum="6A4C19FBD21E7408" modified="2025-10-08" version="1">MTAVNGFASGESNVVLITGAAGWLGGILAGELLSDPKTPNVHLILADIVEPKAPKGAKHVITRKADLTNKEEIEALFNTEFGVPDTVYCFHGIMSRGSEDNFDLGLKVNIDSIRMMLETARKSRPVSGEPIKFIFTSSLAVYGGPLPHVVDIHTIATPEGAYGMGKLSSELLVNEYTRRGLVDGRILRLPTIVVRPGVPSAATSAFISGIIREPLHGVEAICPVGDSLESKELELAAWVASPETTIKNFVIAKHIPAEKFLPHTRVAYLPGFTVTVREELEALEKVAGPEALKLIKFKDDPINRRIVGSWPARFDNSYPCSLGFVADEGGMVPVVQRFKEMVEAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C340</accession>
    <name>A0ABR3C340_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616165.1">
        <property type="nucleotide sequence ID" value="XM_066755879.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988180"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0253944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="42417" checksum="DCF32B53C3F5828E" modified="2025-10-08" version="1">MHILYLDTSSLRAIVTPLRMLLHSPRHQLPKTAFTTLRSKPLHKPILLSAMSQKAGYSSLTEQVTSAASAASQAVSDLVNKYTVHDIAKKGFAEGTNDFYDAARPSYPADALRVISSSLPSHPLKIIEPGSGTGIFSRLLLAPPSPAYPSFSIDILVAVEPSEGMRNSWWKALEKAGLGKREDNEGGKGEKKIGTVGGGFDSLGAAREYGVTAVQNGQGGVDGVIIAQAWHWCPDYDKALREIAAYLPPNAPLILIWNLEANDPQWQAELREAYQGYDLGSPQYYKGLWRKMFETPAYKELFDSSEQHTIPWSVGITEDGILDRLLSKSYLTEQHLNGERREGFIKKIRGIVRQATHEWIDKEKGIFKYNYNTDVVICRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3P9</accession>
    <name>A0ABR3C3P9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616544.1">
        <property type="nucleotide sequence ID" value="XM_066754643.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986922"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="284" mass="32127" checksum="4AEA5B9E35796280" modified="2025-10-08" version="1">MSRPAPVKSLDARLKMHDGNAIPQFGLGVYEMNDKETYDCVKWALEAGYRHVDTAEWYENEAPCGKAIADFLKATGTPREEIFLTSKLKNNAGYEEALTDLKNSLKRSGVEYFDLYLMHSAIGGPVVRKNVWKALCDAQSQGLVKSIGVSNFGKKHIQEFIDQKVPLPTVNQVDLHPFMRHPEIVEICEQNEILLEAWGPLARAMKFDHPLLVKIAKEKGKDAAQIMLRWGIQHGFVVIPKSVSQKRIVSNSKIFDFELSSDEMKELDGLDEYLVTDWDVVDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3V7</accession>
    <name>A0ABR3C3V7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616590.1">
        <property type="nucleotide sequence ID" value="XM_066754689.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986968"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="124" mass="14284" checksum="87F477B1EF590A0A" modified="2025-10-08" version="1">MITAQVESQRRWEKLISLQFFGLGLFQLYSKNPTSRPTIIRQSDPHPRTHPRPSQPAPPNKLKKQFPGWLRLQQSIAEGEAKPQMMVGSKVSAKHTRDAQRRHKAWYLRVDDVLSITPFRAGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C412</accession>
    <name>A0ABR3C412_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100173</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616647.1">
        <property type="nucleotide sequence ID" value="XM_066754746.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987031"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="170"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="346" mass="37100" checksum="F67F21E0CFDAE17F" modified="2025-10-08" version="1">MASKQHAHLLSLARGMIPPLHPKLHKGQAGRIGVLGGSGDYSGAPYFSSMGAMRFGADLAHVICEPSAGAVIKTYSPDLIVHTILDPQKSREDIRSALKGVMSRLHVLIIGPGLGRDDHMQSCAKIAFELAKDMEQMGVVVDADGLWLVQNEPKVVMDWPGVPRIILTPNVMEFKRLCDTMKIDPSGPHTSLCPQLATALGNATIIQKGPSDIISNGLKLPSSFLSDESEGEQNYLEVKVEGGLKRVGGQGDILSGSTGVLLAWGSEWVRGSYEHVGHPPPQEKAIAENIPVLAAYGASTFNRTVSKRGFQKKGRSMVTGDLVDMVGDVYEEVFGNPGEMEGRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4L0</accession>
    <name>A0ABR3C4L0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616842.1">
        <property type="nucleotide sequence ID" value="XM_066754941.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987228"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="327" mass="37512" checksum="635C53B674261D3C" modified="2025-10-08" version="1">MADWKERERGRRSGLAEKNLVSTAVRKCAEDDQFAKLKSKPTNDELRGRVIDYLNSVVREKKKRAEMKVKSIKSRTARFRVWLVNNWESTSLDACGVAIEPGRWSPIIRLTVWMGYESWLQAQEKSKRRSTPVFHLPHMYRETTSMGFRLPCGHTSLEDRPVGLFHPTAEYTKGMIDWDAAQKVDASHIPSYEVPSDPARSQSRQCRRPLLEILQNNHSSVYTSLQKRLILLPQITSYILRSLWESRCGEGVAQYESRLQRTITGVRYRSFSEYLDAASTSALDSSLEMEGARFDFAQEVDASGNFDDFVGKGEGEEEDLNNEELVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4R2</accession>
    <name>A0ABR3C4R2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_100413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616885.1">
        <property type="nucleotide sequence ID" value="XM_066754984.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987271"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="787"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0255608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="849" mass="96001" checksum="EAC38FDB54EC509A" modified="2025-10-08" version="1">MATNYPSLFRSEEMSLVQLYIPSEVAHDTISELAEMSNFQFKDLNPSLTSFQRSFTPRLRRLAEMARRLRLFRSQITSLSPPLGIPPLASVPPFTTVGPRAQNAYDELEEKLKEHERRLNEMNKSWEELGRRKSELEENKCVLKETAGFFDEAGHRHTEIRTSMEDSSDAAPLLEHAAEYGTLPGETGLSGFDLEFVAGTIDRTRMPTFERILWRVLRGNLYMNYSEIEEPFVDTVSGKETFKDVFIIFAHGQELLAKIRKVAESMGGTLYNIDSSTDKRADALRQVSARLEDVDNVLYNMGQTRRVELSKIAESLEAWTDAVKREEEIYKTLNLLSYDQGRKTLVAEGWCPSRDITAIQLGLRRAMDTAGTSVPAILSELRTHQTPPTFHRTNKFTEGFQTLIDSYGIATYQEVNPGLYAVITFPFLFAVMFGDIGHGILMFLTAAAMIFWEKQIAKNGVNENVETFFFGRYLIVLMGIFSVFTGFMYNDIFSKTLHLWQSGWEWPSNSTGLVEAESTGHIYPFGMDPMWHGSDNALIFNNSYKMKMSIILGVIHMTFAICLQVPNHIHFKKPLNIYAEFIPQMLFFHSIFGYLVICIIYKWSVDWSQSATSPPGLLNMLIYMFLSPGTIEPGTQLYAGQGFIQVILLLIALVCVPWMLALKPYMLWKEHQRIVAQGYQGLQGQDNGGMNGRNSIGAESRAEEEEEVGMAVAESSDEEHPFEMADIIVHQVIHTIEFCLGCISNTASYLRLWALSLAHAQLSEVLWSMTLQLAFDFNGGLVSRAVFLFIMFAVWFGGTIGILCVMEGLSAFLHALRLHWVEANGKHYMAGGYPFTPLSFATIGQEEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4W3</accession>
    <name>A0ABR3C4W3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616936.1">
        <property type="nucleotide sequence ID" value="XM_066755035.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987323"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="339"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="600" mass="69029" checksum="4EB122C7DBA58539" modified="2025-10-08" version="1">MAPSRAYTPPVSPKPKNTNLSHSILPHGAPQVPRPIRRPKKIIYLAVIFFLLYWFGIRHGLGRERLPIPPLGYAVNGGRRGRKSSLAWDSKGMATLLHPQPGIKQEHPIYELMERAETRWTTMLASQSTTLPQAVAQYRKRYGIEPPLGFDVWFDFCKRHGIKIIDEYDQMMRDILPHHALPPAMFMARSKALEGAAYTYTLDISQEHVSVTGERSTYSRPQHLQKLIAGFKGDLPPEFRLRVTGSDHDTGSVVLGRDQRTRAMELVQQGKHFDEDELKSLENPNRTPAWGWFKACPLDSPANIRPWSENATDEFQLLSKFPFDSSFQTTPMEGYMNITEEDVPFLAKWEDKIDNRLFWRGSTTGGYTAQRDWRESHRLRLHLMINGPKGGDAWWDQQLRDVMVPDGEGGFKIVRRWERVLSKAYADVKLSGQPVQCPSEEICKEVANTIEFGKKVWPDEAAVYKYNLDVDGNGWSSRFHRLLSSGSPVIKFTMFPEWHQEWLTPWYHYIPLKPDYSDLYDIMAFFVGPLDDAGHIDYSKGHDYLAQKIGNAGQKFALEHWSWVDMQAYMFRMVLELQRLHSLDRSSMSYKGPAGKGKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5E8</accession>
    <name>A0ABR3C5E8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617124.1">
        <property type="nucleotide sequence ID" value="XM_066755223.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987514"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="1">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="99" mass="11609" checksum="C870693E7999BF3A" modified="2025-10-08" version="1">MGITCEDVLFAIYDFFASPLYVDELGEMHPRAVRIMEQQYFEKRRMGFFDLMEGYRKSDALLGATYFDGIHNDPESVERLKLKYNFHSSNLLLLRLGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5F5</accession>
    <name>A0ABR3C5F5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617130.1">
        <property type="nucleotide sequence ID" value="XM_066755229.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987520"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02223">
        <property type="entry name" value="cupin_Bh2720-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052538">
        <property type="entry name" value="Flavonoid_dioxygenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346">
        <property type="entry name" value="LIGAND BINDING DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346:SF1">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="177" mass="19430" checksum="A0E07CFAA31F943E" modified="2025-10-08" version="1">MSLTSVTRIVSKSILGAPFTSTARRLTTTVPRFARMSPPAHKMTHFPRITSSLPSEHSDFRTVMWTGESSQLVLMTIPVGGEIGEEIHHVDQHLVFTSGTAKAIVGGEEKEIKAGDLVIVPQGTKHNFINTGPTPLCLFTVYAPAEHAETTVNRTKEEGDKLEEEGKDEPPEWAVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5T0</accession>
    <name>A0ABR3C5T0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100329</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616802.1">
        <property type="nucleotide sequence ID" value="XM_066754901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987187"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="456" mass="49760" checksum="6AAE667FB157EDF6" modified="2025-10-08" version="1">MSLTSKFSLPQSFSVDANDQSISSIPSPPSLSSGRTSPDFDFESFTHYSPNPSSLVDEIDSTELHQGFSSTPPSTDLVSPRSSIADISQIQPPTQVEEVDTAEALSKHHLQRYLHYKTLAARAEADRAVVIHQQAQSHSSDDDFDALFAACDKSSVLLMPDASGNSTFFKDTVVSGDSHNNMLAYQSQMVQPTYYQMGQAMPNWQQSGGFYHPQPSHAALHNAQAQAHLQAAEAARFQAEQHRMNMSNFYVPVSAGPRSSYDATSQNAPSFAGQSISNLTTQSPSYSSTRSYPVASNIVMDKTSSMSGLTTCASSRRASEEGEEELAYTSEEEDVKPILGSIPIVNVHGGGRGYVPGQTPDDPKKKHKCQVCGRGFARAFNLKSHIQTHNPLRPKPYQCPHATCKRGFSRLHDLERHRQGIHSDGPLVDAKRHGVTPAVARAQNRIQKRAESGSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5U3</accession>
    <name>A0ABR3C5U3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617265.1">
        <property type="nucleotide sequence ID" value="XM_066755364.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987657"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1710.10">
        <property type="entry name" value="abc type-2 transporter like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="161"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="559" mass="62116" checksum="EEC53A70AB4814A9" modified="2025-10-08" version="1">MSLSRTATFTNDNGTISHTSLPTLRNEPIMSSQFTANLRPNAGERTESVPGPSAPEPFAPNDQEYGSEEKIRSRAGTSQSGKTFRNSSGEEKGLDVNDVPKASEFHSPEAKATNNLTPAAGSAAAEPGAGKPKLEKFKYGFWDTEMAMFRKIAFKILGGTIVITIVVMWLCLPFYWGSLWKSNRYTNKLTVRVIDRDGGEIGQTFSQGLLSQTNLNYFATDPSEFPTAADVTHDIVEEGAWASIVINAGVSDALLSARQNGNTSWNGLSVIDVYYAQARQETAINSYLIPFIQQALSQLSFQYNTQSAATYLQDNVNNATAVSLVAQAPTTITNAVWFSMNNLRPYDQPVAQAITLVGLIYMLIFSFIMTMTNNAVREIIAPFLTTRSYIFYRLVSPLCLYFPVSFFFAMVNLPFKIDFGAHFTYAGGFFLWWFALFLGMAAVGLSTEAAITVLGPKFMAFFLVPLIIVNVSVVSLPHELQPWIYRYGVAMPFYNCSHIVRTIIFNTKNEIGQNMGILIAWVVVNFITISLGTWLFRRRSVNQHNKEVGENEMDSFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C604</accession>
    <name>A0ABR3C604_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617181.1">
        <property type="nucleotide sequence ID" value="XM_066755280.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987573"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="85"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="543" mass="59367" checksum="C56E09E3055B9B9B" modified="2025-10-08" version="1">MSTSNLPPQAQEHKLHHEDESEFILPERRSSSVRDQLAAWHANRGDKSFVRCMIPSLRQPVAGEEPETKNPFKIIRSVSPFAWLMFFSGWLAWTVDGYDFFCVSLTLDSLAKQFDVPPSSITTAITLTLLFRSLGAVIIGLCADRYGRKWTLVFNCLLIMVFELGSGFVNTYKQFLAVRSLFGIAMGGIWGCAAATGLENVPPIARGLCSGILQQGYSCGYLLAAVINLTVVQQSKYHWRTIYFFGAGFSLLAAIIRACLPESQQFIVAREEAKERGISSKQATKNFMRELGNMFRTNWLRWIWAVCLMTFFNFFSHGSQDLYPTYLKTTKGFSSSLASKATIISNCGAIVGGTIAGHVSQFVGRRFAILVCCIYTACWIPLWILPDSFAGLSAGGFFIQSGVQGAWGIVPVYLGEIAPPAFRALFGGLCYQLGNMASAGSAQIEADAGKSLKLAGTNIPDYAAINGILIGAVIAFGIVVIFLGPEADGSHFEKAKVAIERGGGEVAPTDLFETNNNDVPRQSLDKQELSHVETAEVQHKEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6L5</accession>
    <name>A0ABR3C6L5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617253.1">
        <property type="nucleotide sequence ID" value="XM_066755352.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987645"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="814"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="867" mass="92945" checksum="F31D319598B15FFB" modified="2025-10-08" version="1">MEGSPLSRFPPITASSSSSASTNGASGKRKSTLLTFLRRPSVEGSTIAVPQRQSVFHDMERRPQKPLRQEELLSVVGGEKDVDPNLPTVRLVPPDDEGEPMMLYPFPLSPPPSLDTQSPSQQRTPPLAPSTPSPMPRRPLATANGPRPTSAFTTNPAWNGMADGFVLPPPRFSRSGAGFNPRGRASVIMPKTKTQVVEEKKRRMSAMMEWEMGYGGAERQVMNRPMLIRQGMKPPSVLEAEEERAAMAKITPQSGLTKPGEEKIEELSEEPAIAASTPSAPTTPGPPIVTVNTQSPVTSQPPAQLTKDHPFQPATSKPSKPSRRSRTLSLSAAFSAPLFTKNESPATTSVSSLPPVPPVPTEQTKRVPKKQKSLKNLFFSSSTPPTTTLGPSKCDNSSQVAEKEHKDKLETSKEKKPLLTKRRSKPSLHINVNATKSSSSLKSAPATSSSSKTSAALITPTFSSGRSEKNSSISTTPSTASTATATSASGTASKPKLNKRFSLSNMAVFKKRSNSAPVFENRSLADMESGNAKEEVPKVPELPKAYKKEKEARRTMSEMFPAKEEVAVLPQAPFADEIVASPVAEVPKNIIEPPSTHSADISTGSSPTHSPSDSTSTIDPTSTSVSSDMSDVDDEDDILNAQFMQLPSPRSPIDRDPAASLQDLLNNAPGRKSEVVVVQEGRRSLEALVVLGPTSVRPNTVPTNSRMSASGSEASFASCYSGSTLNFGSSPQRKQSLGPGAVSRRSAGSDESDDVEGLVTPVQDSVEMFRVQRQRQESQSEESNAGESTDSEGMRLIKNRSSRKICPTVSPINASSTSRSAPTRSLPAPPETMSLEAKKKLGSLHFDTLGLNFGEWNGRREEVPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6W8</accession>
    <name>A0ABR3C6W8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616526.1">
        <property type="nucleotide sequence ID" value="XM_066754625.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986904"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31826" checksum="36518298F1533B76" modified="2025-10-08" version="1">MSQFNLDELSSFREHYHAHGYVVVPSLVSDNLLPLLREAADHIVDLSRSGKWDNVRVVGKPFPPWDAKDKEDIWGVQNVMHPDLGQKVFAEWYGSEGMLEVSRALMGCEQEDMQFELFNLLINPTNAAYTLVWHRDDVKPTATPQEEIAALQKDYHGIQWNAALYDDECLSVVPKSHLRVSTPDEKKALLGEGEMPGGMKVKLKASETVFYNNNIIHIGSYDPTTKRRTLHGCYGCPPPGDTSRARNILQHDLTYTLDPKFREIESCYYTGAASFLNLVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C739</accession>
    <name>A0ABR3C739_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617237.1">
        <property type="nucleotide sequence ID" value="XM_066755336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987629"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="72"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="254" mass="28502" checksum="D9AA0CC02C1516D7" modified="2025-10-08" version="1">MISAIHGIETLENSSGISSISHTPSLAPRGIEPPPPIPIRPGSPASPNSVTREPTQSRSTPSRSKGKERGTPELPTETIKDVQGEDLFYRTFRGEESDLENIMKLVEEELSEPLYLSIFLVRLAAFNILGLPLPNLYPSNSYDNIVAKDFRRRGIGRKLVEIAVEEMAKRGAKQVMLETEHDNQTSLALYDKLGFLREKRLHRFYSNEKDAFRLILPIDTEGENDEALSQQLERTGPGLGYIGEEEDEMSPYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C7Y5</accession>
    <name>A0ABR3C7Y5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617138.1">
        <property type="nucleotide sequence ID" value="XM_066755237.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987528"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="25715" checksum="12CBACE0499C7B46" modified="2025-10-08" version="1">MAHFAFIITSLKAFACIWALVTFGVGASFVSTVNDSFGNHFVTHTDLTSGNAIIAAGVLTWLYFVAVLVVTFIQPENVFISVMLDTVFLSIWFIFFLGSVASMSTLASVFRDYDRFTWGRLGTATIGLGWVMTFLLLGILLFEVVYTLINCGCSYTIWRKPFNRLVTYGNSTSGGGIASAILDDANMGTVSTGVPDTHAANAITKGPIDEQAVPLSVLTTSEGIAAPVPPGIHPPASVPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHK8</accession>
    <name>A0ABR3BHK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106737</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610697.1">
        <property type="nucleotide sequence ID" value="XM_066761157.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993590"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="419" mass="46169" checksum="2D7F114C84266A68" modified="2025-10-08" version="1">MTSVALAKHVLIVGGGIGGPVLAIALARHNIRSTVYEIRPFASNEGGALIISPNALCVLDKTLGMKDDILNAGYQYDDINIYSSDGLWLGAMVNGDEDEWGYRGVRVTRTALHSKLLDRCHAMEGMVSIQYGKVCEKVEEGEHGVRVTFADGTYGEGDILIGADGIYSKVREQLLGPASPSLVYEGLVGLWATTLRSEINIPPNMTLPAAIYTPPGLFLLFPIDPSGKTIGWIAQRSAPERSKGGWKEYETSGDCVRATKTDYEGVDYEPVKSLIASLEEGQGKVWPPYSIPDIPTWHSKRICLIGDAAHAIPPSAGQGASQAIEDAGLLARLLAHEPAVEKGYEQLFEYFEKTRRTRFQSIRSLTRQSSASRFELKGTLGWWLRKWSIWTFLRALGSKGYYRDTKLMGYDITQEKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIL3</accession>
    <name>A0ABR3BIL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 10">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 10">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 10">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106672</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 10"/>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610919.1">
        <property type="nucleotide sequence ID" value="XM_066761094.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993527"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0240420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="478" mass="52939" checksum="39173F8FF65C343B" modified="2025-10-08" version="1">MVLIRLSVPKRGVRLFCRKSSTIAPKTTVLQELDERGFVAAITSDKLKQRVTSPTTIYAGVDPSASSLHVGNLLPLLGLLHFQAHGHQSICLIGGATGSIGDPSGRSTERKSLTPSELRLNIAGITSQVHRFFIRGQEYLSKRGVDLAAMRKDGGRGVKVMNNYEWMRDVSLLDFLRTTGKMARVSTMLSRDSVKNRLSSDSGISYTEFTYQLLQAYDFSHLHSEHGCNIQLGGSDQWGNIVAGIDLIRRGKIAEREEKDEQVKEEEEDVYGLTIPLLTTSTGEKFGKSAGNAVWLDDKRTSAAEFYQFFLRTTDEDVEKYLKLFTFLPLSRIQDVMQTHQASKTERLPQKLLAAEVTELVHGPAALSRALTAAQVLYPTSISSLTAEKVLDAFRGDMRFHRVKKEDLAEMGVGKVAVTYGLCGSVGESQRLVQSSALQVNDRKIGDHREKIAVEDLVDGHVAIVRAGNKRQIILYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIX9</accession>
    <name>A0ABR3BIX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611126.1">
        <property type="nucleotide sequence ID" value="XM_066760854.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993280"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="154" mass="17120" checksum="A03E18682CCE904C" modified="2025-10-08" version="1">MGPITPAMKHFLSAERYAVIGKVLSDRSRWDNKVLRWYQTHKYPVIPVRPDNPSSEAIEGLDVLNDPLAIPSLPSTSVSIIIHPFKSLGILQNLFSDPSQAPHSVWFQPGADDENIWKWVKEKGLEDKVIGHGACVLRDGDGVLAAIQEDKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJC8</accession>
    <name>A0ABR3BJC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611282.1">
        <property type="nucleotide sequence ID" value="XM_066760521.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992929"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0241900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1068" mass="118500" checksum="4F8CB615EC81695C" modified="2025-10-08" version="1">MSLPQHPPIPPSPNHPPRLSLHPLSPPAHQSRGHHQPAAYFHYPPSAHPPQFHYPPPPPVAPILAPRPPSDHHTNGSNANGNNPWVNRDFPANSHMHHASSQSETGEYSRPQISRRTTHQPPPSDSMAEYNQWKSSRRNSEVSSIPLGHLEPEQHGFEWNARHNGLPQPEPPAVDAQTKWQKKRPRTTSMSQHESIVDVTQQSKQPQQGQQVGSTAGKPVYPAVLTREKKQKACANCRKAKLKCMLEPDENACVRCKARKEKCAFYPKGHDDDWQQTLQSDLYAATNHLSQLSAAVNHILSHLVSQNIVPALPTPLEQYEHPDRETVLTYMESKKKNSVGNDDAIVEVTKKSKRMKGSKSEDSAEDGDSLPFATSPDGTDKPQKPPPSEITVPQTMSSHSAHSLHQLPNTLFPSYSAPDIISNQNLPSINSQMFSPTSSSARLGPTQQSFSLPPLHSDFMSTAQDQRVTPTSLQNQSPTSGISSSSPSQSTLSKSNAARQLTLSVPPEHTEVTYAPIQEEYRSQSQEDSHAQSGAQRHLTSSMRDEPIKGGQYDAEGEHEDENGMEIVLGSKDPRQDIIKKDIVKNRDALVLVNYFHGHLSNFLYGYRLQFRKFPYLEGGPSTITPLILAVLCLISSERFAIHQHYRGPLIDEVQTLLGSSPAESWQTFEGDQSKGFGDIEADDPLDAEFGLGPEEIVAACVLATYMTDRREGALIARFAFRWARGWIKLLSSTPPRVTLAETAGFVPPERKATDQDMARVWLLCYIVDSTERLQFTDIPAPLSRDALSYCNLLIPPSTTYQSPFFSARSPPRPEDAPDPHDILLTSHARLVTILNEWRHRVEQIDVPNADRKMYVAQLKRLAGKVNGELEWWNAGYQAAKPSDVKNNNGEAGVGESKGLSWRYTEMTWLFIKMLVNSTMAKALSPSPTVVPHTQPLVPSIASSSTSHNSTTLSSSDSKLREASIALVVDCALEILEMCARWAPKEEIINFGPTYLYFITLAGNELVSALDDGGGEGVVSIDELITLFRTVGEALFMGELHDQHVTRMTGKSLFYNCDQLAMMKSWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJD8</accession>
    <name>A0ABR3BJD8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycogen debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610903.1">
        <property type="nucleotide sequence ID" value="XM_066761078.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993511"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="3">
        <location>
            <begin position="80"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="4">
        <location>
            <begin position="198"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="5">
        <location>
            <begin position="795"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1593" mass="177721" checksum="080A581AB37CC1A0" modified="2025-10-08" version="1">MTILDSLKPSNIEIPLPKAVPQPEGKKTPKTPQDEAISFFSGEGDGEPVQIWELSLEDDGGPSPEKSYLRLPPPFKPYVLRFTLQPGTDVTRNGALKSDFPMDGGAFKRGDWKERKLPSDLSRPIEVDLPISAPGAFCYFIEYDSPDSTGRVQGRKGYFNVDPIITLPSRAPFFPPDTPMTSGPLEDESSGAILPKDKQLSLDSLIIISVLAKWMGKTTEWEPFFVEASRRGYNMLHWAPLQQKGVSGSPYSIQNQLVFDVDLLKDPKAKDGGVKEIEEVLKFAKEKYGLGGVTDVVLNHTAYDSPWLQEHPEAGYSPYNTPHLAPAIEFEDALLSLTTRLSSLGLPTSLKSESDLQALIPHIKSSIDDAKLWEYYVFDVQGLERAIADSLLNSKPEAPKPWDGVSLQGKTLDELADIVKSSNIITSYRAYSSRYCTSVPPAVAAGFIQAAYPGDSAENQASRWGKILDVLNVNLYKECNEDIQTGIDGVIGRLRYTRLEEGGPKLGELTEERAIVERYFTRIPKNDITKKHPESALAVANNGWMWAADPLNNFAEYPSKAYLRRQVIVWDDCVKLRYGSQPSDNPWLWQHIISYAELLAGMFDGFRLDNCHSTPLPLGKAVIDAGRRINPNLYIMAELFTGSQEMDLKFVRELGINSLVREAYNGNTVKNFADLLWRFGLGKPVGSMDVACLTSSGEVHLNLSSSKSSARPARVTPLQGSVPHAVFYDLTHDNQSPRDKRTAEDALSTGALVTFCAAALGSNKGFDDLYPKLLDLVTDNRKYEVISKEKEKSSGIGNVKRVLNALHVEMMEGGYSEGYVHEDGEYLMIHRVHPITHKGYMLVAHTAYPGFKGRGWVNPIRLGRTSISYIFGASIKTRFEEWKDDPSTHCGIPSTLKEIAPPEITKGTENGEEYQEVVVPEDFAPGSIMVFATQMSDISGDLDAFCKEGAIEAMSQLDLVDLNVILHRADGEEQDATGGDGTYTIPNYGPITFCGLEGWMHPLREITKKNDLGHPLCQHLREGTWAFDYVVNRLNKQTGDLPHLAAPAKWFASRFDQIKATAPSFMRPKYFSLVIHEAYKAARRAVVEQCSEFVSSGHSFIHNLALCSVQMYGLVKSASLDPGKPVPSLAAGLPHFSAGWARCWGRDVFISLRGLFLTTGNYPAARAHILSFGSTLKHGLIPNLLDSTRNPRYNCRDGPWWFIQNVQDYTHMAPNGLTILSDKVKRRFPADDTWVPWNSPRAYEYESSVAELIQEILQRHAEDIEFREYNAGPNLDMDMRDEGFNQKIWVDWDTGIIFGGNRYNCGTWMDKMGSSEKAGNKGLPATPRDGAPIEITGLLKSALTWLDKLSKVGKFPFKGVNASVKGQKRLVTYKEWSDLIQASFEKHYYVPSDPAEDDKYVINKGLVNRRGIYKDVFGTPKDREWSDYQLRCNFTLPMIVAPELFTPSKALEALRIADAALRAPLGMKTLDPSDSQYRGDYENSNDSTDQAIAKGWNYHQGPEWGFPLGWFLMAYLKFDRLAGEGKSSPTKTMHYISNILRNLARHIENDPWRGLPELTNSNGSFCYDSCNTQAWSASTILDVLEEMHKSGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJF5</accession>
    <name>A0ABR3BJF5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_106098</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611306.1">
        <property type="nucleotide sequence ID" value="XM_066760545.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992953"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="290"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="648"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="856"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="902"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1037"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1485"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="132"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="970"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1081"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1129"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1146"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1318"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1343"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1363"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1420"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1430"/>
            <end position="1441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0241924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1529" mass="168910" checksum="2D864C7FD8D5B2ED" modified="2025-10-08" version="1">MSEDEFGDDSIFLDDSFLRQVDTISAQVTAGSSSSRNDGLRPATAVSRTASHDEVSPRRSQNVHGVGRTFSAPGPISKPLSYHHPAAISRQQAVSKVPLQPSSDDYDLIDIPTESLAAFDAIIANPPKKPSHPSFSGFPPKPSSGALSSRNRSGPSRPSSSSARHPVSSNRQDNFHQTHLNWRSESRYTRGKRWDRTQFAKTGRRIISLAGRDKVSGGKGKDRESIAPGWGNDAIDEDEFMDDDMGDLLAPAPGDFNAPYGPQKQLPSKATISTYIYPTNHPKRDYQFEIIRNCFLDNTLVALPTGLGKTFVAGVVMLNCKRYLVRPSLTHSVYRWFPTGKIVFLAPTRPLVAQQIEACQLSCGIPSRDAAVMTGEGGARKGRERLWEEKRVFYCTPQTLDNDLKNGAVDPRDIVLVVLDEAHKATGNYAYTTIVAYITAHHPYFRVLALTATPGADVEKVQNVVDALHISRIEIREAEAPEIRKYMNTKHTEKHVVAMSDVIIDFRDRLSALMVPFIKKLVDKDILTERDLDAKRLRPFRITAKKMELGKSGQRWAFGPLGVLDKMARAMSHLLEFSLGMFHSSLDEMVSTGGKPKAGAGGANSIANNFEFQRLQRDVSQELSSIKIGRNGKTGADRHPKMQKALELMLAYFSQAEEEENTLGQKNNTRAMVFCSLRPCVMELVDMFNEHPNLLRATKFVGQSNGKDERDKGFNQKEQKKTINEFKAGTFNILVSTSIGEEGLDIGEVDFVVLYDMPRQSIKLLQRIGRTGRKRDGIVHVLMSENREDMNWDTAQQTHRDIQEEILHSRNLELFEDVEPLIPDRKMPECLEQVMPVDPWNPDDPQYKKMMDEGEKELRRMQRAQQPPASRKKKKPLVNEVPVNAKGFTSVRDLLREADKVLLRPDTEEEDGEVDGGKGKGKGKGKAKAKEPAAPKIKHRARKRARTPSPIQTESEDGEDQSMEALFSALEKEDRTGEPSSKRKAPVTKAALVTKRARKSSPDLSIPSLAETESAAKALVSTGKPTVDALQTEHGIVSEVDSDNIPVSSPQPALSKVLSPQPPSATPEHANAMQRKSIQQKRAEAAEKRRLAEARAAEARQRHLQQPLQQQNQQNQQKKEQDQTGLDFFHAEGPLRRGLDPLEDTSSSSEKAASSSPQKSCFSSPSKGAIDGEILLPPSPQRPYSKPNGNKLSPRTAAAAGFSQIDPIDLSWDGDDDDDADAAHWQVSPSHLVRPLLPKTPGSSVNTRPDMPPPPVPSTARRSILPSSPFAPPSEPRAMSTSVGDTQFPVRRIGMARRRIVLPSSEENNSPAGRAINTYANPSKVQSSGVVDPDSSPMVAVGARRRPGRLRRRIAIDPSSSPVRDEPSGRSDQPHARVGGREGRRQDGRQGGKKKKGPIGNFMDLDAELSGNDSGDASEHSASSIANSSDLNFANDFTPTQAPKGYNQRAIYLAGLSTQAQGHGLQFKRDMAKEREEFLQRARRPVYITDEEDGGPRRRSSEDEYELGSFIVDDEEDVGFISHSDPLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJG3</accession>
    <name>A0ABR3BJG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611116.1">
        <property type="nucleotide sequence ID" value="XM_066760844.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993270"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="219" mass="25065" checksum="9C8C791704DDCCD0" modified="2025-10-08" version="1">MAQPIEQWITEIPPVTRAWVAGSIGMSLLVECQVVAPLQLYFSWKAAIINMQVWRFITTFLYFGPVSLDLLFHIFFVMRYSRLLEENSFANRRADYAWLLFLCASFLLLVSSVATLPFLSSSLAFALVYIWSRRNPSVKMSLFGIITITAPYLPMALVLFTWVFQGGVRAAVPDIVGALAGHTYVFLQDYWPREMWSTTGRPEIQTPGFVKRLFGQEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJH9</accession>
    <name>A0ABR3BJH9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611331.1">
        <property type="nucleotide sequence ID" value="XM_066760570.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992978"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0241949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="94" mass="10294" checksum="58119D05024B6256" modified="2025-10-08" version="1">MDALGPFSFKDTNTTSIGFEYLELDMGVDTDDVSVRENSENGISYKLRVSAISVFPLAGNGTKALAEHCFSELLQREASLNHMRGHRTLPQGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJI8</accession>
    <name>A0ABR3BJI8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerol-1-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611345.1">
        <property type="nucleotide sequence ID" value="XM_066760584.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992992"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0241963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="25603" checksum="8B89F8B29D149619" modified="2025-10-08" version="1">MSKTSTTTTRAMLFDMDGTLLDSTPAVLATWEYFAKEYDLDLHEVLRTSHGVRTVDNMRKWCGIEDPIQLRDATETFESMIVSEAKQLQTAGKDGLIALPNVLPLLNKLNTSSIPVWAIVTSATNVYASAALPTAGIPETPKLITGDDVRKGKPDPEPYLAGAKALDVDVKDCIVVEDAPSGIKSGVASGARVLATCTSHTREQLQGIGATWIVTDLSRVTFEIEDGRVKLTIDETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJS1</accession>
    <name>A0ABR3BJS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611053.1">
        <property type="nucleotide sequence ID" value="XM_066760781.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993205"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00298">
        <property type="entry name" value="ACD_sHsps_p23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="50103" checksum="ECD0A4526567C685" modified="2025-10-08" version="1">MGEPPDGSNSPNVPPLVAMSAGAQLPLHGSPSSSSETLLTSSSRSSSSSGPNLTTPELQPYDHQLPPVFHSHSPDTSPSGSTPSTTHSKGESTPRAEISAPVWPLSTAPSIAEVCDEPSAMACIGPSIDDQPSAVSRSPSLKRGNSWRKKHASLDTPPTAPHHDPSFPSFTSLGQIPPLSQALRPDIGSSVARSPAAQAPSTAVANPEVKRFSRESHASTSCQDKWTRAHSPSTGCQISAPISPPMGYPLSCYSGERRNSSSSGLAPSASSAASTASSSSGKSSNRNLSIPPQAPRWAQPPAITNSYSGRALSFGSGQSRPDINIDDFDPELFEGAEDEWIEMIKGPQGRIAIKSTPSAYDIMVWLPGFSIDNITIATRGHRTIHIVADQWDEGDHAQWDIKLGEDANLKSVNAKFTGKELRVTVARQLPEWQIARNSRLSNAAINRPNPCSGASITATNINPLERATAARNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK19</accession>
    <name>A0ABR3BK19_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611517.1">
        <property type="nucleotide sequence ID" value="XM_066760213.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992619"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="563" mass="62471" checksum="39676756A272C3D6" modified="2025-10-08" version="1">MDRRGATTPVYQPPHLRRSQGPSGDASRQRGWPSAHRNANADGFVPNSGTGMNSTYGGWPSASTNTPPISGASNSRLPSQVQALFPGHASRPGEGGARSARAVAGMDVSSFPVPGSSKTSLTPPQWTSRSAPFTIKSSSTPQISHGRYTPRPSRRDWSAPSSSNPFIPSSLTVTSTPAPGRTFPQQRDRSAFESSAGDIKPMRPRKEENWTKPDKEREMEMMQSISRSGGDGAEGDALKNWETQETYRQYIAERVESHYRKYGTPLHTPPILFPEPAIGKGERKENGKGKELTRIGEELESLDNLVLLFRKLREGVIASGRIDSFAIEVFESSARFAILSNNRPQLLSALSGLVPGLYKAYDAIKTRSGEDPLSDRLSKLELDDRGLGDNRVEFTSLLLLYHLVTSGQVSFNELWLELTAPVKRQLRGKFEENERAAPQEDVLFLRREELSFAKVASTALSSNTFNPLVFFSLISPASKAWSSQRSPYEKIILSWAIPQVREEGWKRLIKCYVSVRTPWVASILGKSAENEEEIAVIENWVQEKGKKVEQGVMHPYIVRLWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK30</accession>
    <name>A0ABR3BK30_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611527.1">
        <property type="nucleotide sequence ID" value="XM_066760223.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992629"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="712" mass="78530" checksum="E58D28084ABBD801" modified="2025-10-08" version="1">MASWVSKFRSPSPCTDDESCLSLRVGAGANADIIHDLDLSLREDKALYNPNPFTLAKRKSMRGGGRKISNVISAEDRMKNVVPTVRSTPEASKCKGHPMVTSNPKDQGKANSSNKEHFSAVARRGPKPAVQNYLPPHIEEEVKPRSKNKRGWVDRNGNPLPDAPPRKKSIINIIEEKETQEEKKAKKKAQAKEKRNRSIQAKKKKKKEEKIEFGLLPKGAGPTEEYPILLALDKQKSLPIKSQAKLKNGEITRSPRPTYSIVEDIGDLVYGRVKSRNDQGNTAADPITFDHSSEINGHKIRSDGSASTMIEGSKANKSCGSVQLSRFSVSKATDPRSSLFKKSYPLSNNREKSQLGRLGSPMQPWVLETPRTDDTIVNTNSMEHPSTMTRVPSSMTPAGDKSFTTTSGLPYSSPLAGRGKMTGHTVEGKWKGKGKLIEHSPEPDLEPNLEGFKSLDVERLERAAETYQSKQTYNAPSPVIARPIPRRFQPLLPIRPFQPPSRSPSPIWSTLPAPTKRKLPSSSSPSKALKTVTSNKFRVPSLFPIPHKRSDAQLPSSPGKVTRLTLFSPTSKGEDARRPISEKSLYTIKTIRGTTYGPSFVRNDMPGGTGNRTAGIKGRLTLPPGRSRGLSGTHSGGISTRWEKENDQRTQVSQNEFSGYLAYDYRDYQSRAGQSGNDYDDGHECEADGDEMDWQSAWKGRSSGGTETHLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKF1</accession>
    <name>A0ABR3BKF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611278.1">
        <property type="nucleotide sequence ID" value="XM_066760517.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992925"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="190"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="555"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="707"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="904"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="973"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="707"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="737"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="840"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="920"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="973"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="985"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1017"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1041"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1064"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1085"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0241896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1271" mass="137817" checksum="4A03E23F9633D1EA" modified="2025-10-08" version="1">MPQDFSIYREPAEYHHSHLRDNVSTSGSRYAPPASHVYSDRASAQTFANSSPTPYPEQYRTREEYISTLDSTIPIQQKEQQTVYNRQVQAQAQQQQQMYQQQGYAHSSHPLSSQVAGPSVYRRPSANGVPSSLAIPDYHDGQSAENVGITQGVNGQGGVERRDKGNRMIDADVEGDGRVGVEDPRADRIYTELKCLGDGSFGTVWLCDWHSPVKPDVLLSAMQCGAGARPEWSGKRLVALKRMKRVWEGGWTQAKSLGELVSLRNIPPHPAIIPLYDAFISPKSRELYFVFECMEGNLYQLTKSRRGRPLAAGLIASCFHQISSGLYHIHGHGYFHRDMKPENLLVTTTGLADYLTAEALAEINRAGGDINRVGDLAYEKDVSVIVKLADFGLARATNSKPPYTEYVSTRWYRAPEVLLRSSEYGPPVDMWALGTILAEMLNLKPLFPGVSEIDQVYRICDTMGDPSSEYGVDERGMTVGGGPWNSGIKLAKNVGFSFPKRKPVKFRSLFGDNVPQSLVDCIADLLRYNPKYRMTAAQCIDHPYFHETLPHLQQTPSLPRIPFSAGQPPPNAIPRPTLSGAPMRPPDVSASARQLPPSHSHTPREARPAFANGDIRTLPPPMGTPDSQASSQRTFFPQHIQGSTPHASSSALVHQLRELDLPTDDLASYGQRPPEAAAADARASQYAQSQTQLHQWVGDLQINSGRQSAAQSTMFEGSQGGRSNQSLPNYSSVSLEQQPPTQVSSQSVQPAQSYGRSNVNVAAYVQQQQRYAQEATPQQAAAPAAPPPIEPTVGAARAEKLGVTGKKKKWGLSSVFGGADKSTASLASVDEHGYLGASLKRTQSGHRTTDRNSSVPGSSLTLGIPALGMTSSAGASNVSVLGDPKKAKKEAERQAKELAKAQREAAALKQKERARAVMQKRNQLIESRSQLKTTGEIEYSSTNLASEAPTPNQTARSMYASSSASVNQLRSYAASQANQSLQSIRSQDSGHSGHSGHSGQSGRSGRSGLSASALADLDEHGRWEEMRHKARRRDDDDDHSMSSFGHNSLKSRSVLTVGTVDSDPGPRRRSEWTDPVLRRDKRVPSASSSSLPFHPQQPHTIMSRSNASLESQLAHDFKARANVGAASSTSSLGHLPHAQSHSYVAQVPVHGSSSSGHLLSMQGHGRGLEFSGYPETIIERHDSAPTSPYGHSKGAAVAMGVGIARNGPAVASGTVLPSISSLGEVEGESQINPMFRVPPAEYQQSAQTLPPFSDIASYALEGQNKHTHPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKL8</accession>
    <name>A0ABR3BKL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105953</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611706.1">
        <property type="nucleotide sequence ID" value="XM_066760402.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992808"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF648">
        <property type="entry name" value="ABC-TYPE TRANSPORTER ATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="297"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="615"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="910"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1043"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1073"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1122"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1188"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1207"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0242324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1216" mass="133432" checksum="C9ABCDD74B2D4550" modified="2025-10-08" version="1">MPLPPLTIIHYTYPILLSLPLPFILTPVSPPSPPPPGLIPITVQRITPRRTLILTLLALLAFTSFLDVTVLVANVLSARVRYGDDLPLYLTGAQLGGEITYALGGLVAWGVALIACLWRNKFSKSLAVLASLGAAGEIVNLVWLVKREVHTGKSEKLFAILSFIPSSSRLLILPLLFLATLSPRVSYEPSDERSGLLASDSAANGRLLEPGTAGAYGTFATGTTTPANPPPPQPEEQTEQQRREERAKQTKIKLTKALGSRRQPKKVLSWSEGWPKFKKLIPTLWPSTNRKLQVYVIITALLILIQRFLNPLSPITLGWLVEALSSWRHPSDVWKALGAYLAVRMVNSYDFISIAQQYFWIPVVQYTDREMQMICFNHLLDLSLSYHTRRNTGEVMRIIDRGSAINELFRTILFSVVPTLSDTIIGFSVFIWLFGPWITFGILAIMVPYCVFSILATRYSQKYRREYIDTDVRQRGIVSDVLTNWESVKYFTSERREVARFEEAVDEVMKVDYQWRMGLQVIYGVQSLLLVTAFAVGAILLSVKIMHGQANAATFVVYITYFGQFTQPLNQLSSLYKNISSDIIDAEKMLSLLGEKTEIKDDPDAKEMVITDGVIEFKNVTFSYDGTKDAIRNVSFKLEKGQSLALVGETGSGKSTILRLLYRFYDITSGHIYIDGQDISKVTQESLRRAIGIVPQDSVLWNDTIGANIAYGKPDASDEEIIEAAKAGRIHDKVMTFEDQYDTIVGERGVRLSGGEKQRVSLARMFLKSPFILVLDEATSALDTETEREIQKSLSNLAKGRTSLSIAHRLSTIINSDKIMVMKEGQILEIGSYKELIEKNGAFARMWKRQIYTEAELLEGDAIDKFASALPTADDFKAFRKEEYGEEKPQTGESDNSEQTVAATLDSNEGLKAQGGHQKGPEPSGELANKPGYQVDTATPADQPGAESFAEVVKSEPHEGTDKPVTYAEAASEPSQSEETDDKDKQPVSSEVDGAVTESVPSISEPSADRNVPVTPKAAPFPPVDGSRRASYPAAQGTPVHRLSTFSTLSASPSASSLSRASPSSLGSDAVSGDSSKQGTPGASSNKEDKRRKRLSSIKGFVRRISDQGGLTRSASGLLKSPKPERGSGRNVDEGLAPESSEAGDEVIDERTALLQGRDPIQGVATPPAPIGGQAAEQVERAEQALAPNSTSQPASTKTHSGSSSRKEKKKKKNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKM2</accession>
    <name>A0ABR3BKM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611696.1">
        <property type="nucleotide sequence ID" value="XM_066760392.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992798"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="277" mass="29147" checksum="C4E7D8827EA5FEF0" modified="2025-10-08" version="1">MPACRVTNNTAHPLNISLKQVTALHFANSVQPGQTVKFRPGKVWFTLEALVDDGSKKSRYSVLKSAATIAVISVAVGAVAATAGAALLPEAAAVETAAAAGVAGGVIAKGVTAAKTALIANSGTIARISSMALPKAIEKLSEETGGLTALQREVLSIIASPTLSSDVRHKSASLLRSLHKSYTDHKAASQESSSSDTPDIDKPSATLTPISDDEAEKIEKDVESGEVDDRVESTAVRTGEVLRVHGIYMKNPREFEIRVGEEGKLVLYDVDQKKFIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKN0</accession>
    <name>A0ABR3BKN0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611727.1">
        <property type="nucleotide sequence ID" value="XM_066760423.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992829"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0242345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="192" mass="21072" checksum="4832519B04095174" modified="2025-10-08" version="1">MLNPLRPLSRSVRHFSSPAPASSYPYNPSAIPRASTTPLPPPPALLHPRNGWSLITHLDNTAARSPWAHLFARRSRDRLPSGSVLTVVTYTDPAKKSISPFSGVLMGTKRRGVDTSFRLRNIVNKAGVEMTFKLNSPMIKDIKVVKRAEKAKGQLKDLKRAKVNYLRERPAVMAAIARALKTAKQNEAAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKN3</accession>
    <name>A0ABR3BKN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611734.1">
        <property type="nucleotide sequence ID" value="XM_066760430.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992836"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0242352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1110" mass="118509" checksum="5863D67862080419" modified="2025-10-08" version="1">MDPSLLHSSEEAKPTADTSPGGSNDPSPNTTAQSHTTDNTSPSTVPQSSQPASQTSNQPKQPSARSQSQPGHDTSTLDDNENAKRPRLRLAHACDRCRRRKIRCDTQHPCTPCQQSNNVCTFETPSRRTVKSKGNSERVSSTGGIKRPHSPGQVFASLATGRGESQSNLEARLAALESMLRDVPPNVHNAFLSTLDARLGSGTGVGLKEGGGGGEGVGVAVEALAGTSLANLNLPGSLGYSMGGSGLNARGRLSQSTLSPDWAASGGLSGWLNDAVLGKKKEEAGMDELAKRLGGMSFFYEDEIGQAKWQGATSGFPLLHLLAAHNAPKEEDEANSADGDISGEMNASPAADSILSTSPNASAILPRRISSSSTPAGRASSAHAKARSSSIGLGAIGRRASSADRRKKERFFPDRTPRPHQTLNPEASWKVITGVIPPDLMDTLVRCYLSTSHLLWPFLHVPSFLADYANPAQWGEPGFTCFIVAVCTLSSRHVDDPRVRANPADPSTAGKQYFELFKRLRDLPSADRPTLYSIQAAFLAAIYAFGLGNLSKAFSLQAESITLCLDGGLHRSVDAYDHFDAIEKETRKSAALFGRPPIIHLRDCDVTEPLIVDDENLTPEGIKDESINSKSRMCAFVATIRLHVILEGVIDSATQPSAFPTSPFLARAAATIARRTPQIETLRDEEELLEEWKRILPKYWCYDTETANSRDPIRITQAERLHCLEHLVKMIIYRHRFSGFVAMPASTAEERARHLNLCRKAMQCALTIIADHVHISQRGMMTYYGVHVIHQLAQAGRTLVAVILNCRNADFRPIIAPSVEGLRSCVGLLRRFSGRYLCGLRSADIIDEFCRVCNIPVDSPRVPNSASRPSPAWLRPVRKRVATPPPIVDSPGSSAMMNFDPNTLISNSVVRASGADDNMTTSVGGIGDIGGSASDLDALFNTAAYFNVPGGEVSGGMAGISTGSVQNVGNQNANVGPSNPFLPTLVGLGEASAPYDRFETLSPNAELGNGNAMLSNYQDSHSGFNLSSDTDHPMGSGLGPSGAGARHISFDYGLNGHGFGGESLATKGMDNVSDGLKQGTGGSNLSAATILSLMEEGSFDYGSIFTDQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKQ4</accession>
    <name>A0ABR3BKQ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_105813</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611566.1">
        <property type="nucleotide sequence ID" value="XM_066760262.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992668"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="12">
        <location>
            <begin position="261"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="13">
        <location>
            <begin position="372"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0242184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="568" mass="63437" checksum="652E6C7F2674F487" modified="2025-10-08" version="1">MPSLPQSFLTRQSSSALSFPSYHGSPTHDMDDKDADILLIEEENSDHGTDPSCRSEDSDRDSTQVDDGPGDEDHLIWALADDLDSDASTQNGGDNNEEAQEALLEQLVRRTEAMRNPAAHTASFYAQSEVSDDDENSFGIDEPYSESLIEDGIQFSDEGREKALDFLESMVLSFLEQISASAETIVSNKTSKAHKKRLKGLKARRNQATETDEEQEIDRSLDAGKIGVTISLKNRKSGSYQPVILPDSPLQRPGRQNSIMRMTCIMRVASTLYEAVLDRNVVTLRDVYYRDKQLFRCQPVVDKIVDDLVATAGLKRRDFYVCASAKGLIASSSFVIRYRTGDEVVLSANRANLVDPAEKIDVIEAPNGLDWVLIVEKDSLCGAGFLQYERIGHGALITGKGFPDLATRQILRLIVDTFPCVKIYALVDADPHGLKILSTYMYGSKANAYSNDYEDLPLRDRVQWLGLRASDWSDLRINYDDLIPLEQSDIQMAMSMLRDHQTLPDEWKRELSHMLHLRRKAEIEIITASSGSNDYVDSNGSGDGKEDGQPLSGVERLINYIVKNMGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL45</accession>
    <name>A0ABR3BL45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein 90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611319.1">
        <property type="nucleotide sequence ID" value="XM_066760558.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992966"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0241937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="698" mass="79117" checksum="AEBDC7333BDD10C2" modified="2025-10-08" version="1">MSTETFGFQAEISQLLDLIINTFYSNKEIFLRELISNSSDALDKIRYAALTDPSQLDTEKDLYIRIIPNKEEGTLTIRDTGIGMTKADLVNNLGTIAKSGTKAFMEALSSGADISMIGQFGVGFYSSYLVAEKVQVTTKHNDDEQYIWESAAGGTFTITEDTEGPRLGRGTSMKLFIKEDLKEYLEEKRIREIVKKHSEFISYPIQLVVTKETEKEVEEEEEVKEGDSKIEEVEDEDSGKKTKKTKKIKETTTENEELNKQKPIWTRNPQDVTQEEYASFYKSISNDWEDHLAVKHFSVEGQLEFKAMLYIPKRAPFDLFETKKKRHNIKLYVRRVFISDDNEDLMPEYLNFVVGVVDSEDLPLNISRETLQQNKILKVIKKNLVKKALELLSEIAEDKENFDKFYSAFSKNLKLGIHEDATNRSKIAEFLRFHSTKSVDEMTSFKDYITRMPEVQKSIYYLTGESLEAVKDSPFLEVLKKKGFEVLLLVDPIDEYAVTQLKEFDGKKLVCVSKEGLELEETPEEKAEREKEAAEYEGLCSAIKENLGDKVEKVVISNRITESPCVLVTGQFGWSSNMERIMKAQALRDSSMSSYMASKKTMELNPSHPIIKELKSRVAEDKSDKTVRDLTYLLFETALLTSGFTLSNPQDFASRINRMIALGLSIDAEPEAAPAAAASTEDAPALEEAGAGSMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL88</accession>
    <name>A0ABR3BL88_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611932.1">
        <property type="nucleotide sequence ID" value="XM_066759986.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992387"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="42636" checksum="46140E70D44ADA7F" modified="2025-10-08" version="1">MSGRPRRAAAASSRHPAPTHTVDLQGADPEFLALSLKQRRAIDKAFEKGVRSIRGGEKRKRRKIANGKAVNVELGAKDEGGIADESGGGGFLEEDGRGGPLSEDPDEFVAEGDAGGFVIDDDAGGLVPGDDQGGFLPEDDAGGFVSDGGYQDGVVSEDSKHLEQQLPSHYSSQTFTKLVPLYLLPTLLTSLGLPSDEDVLQVFRASAMGWDESSNKRALDTEGAAGVELKDFRAVCAALMDPDDGEEMEDVELGSNDDDDDKDNFEPSGEESALTSLSESSYGGTPNKNRSKTARNTSGKTRVKGKGVLEDQISLSSNQRVMVRDIWDMLIPSEKQEKFGADILGRNEVKELVRTLGEMWSDEEITDMVTLFSSQHEGRGLTFEDFGKVMLRAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLE1</accession>
    <name>A0ABR3BLE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611635.1">
        <property type="nucleotide sequence ID" value="XM_066760331.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992737"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="45555" checksum="B9541EBC834437AC" modified="2025-10-08" version="1">MADTSSVAPTTSATPTTSAQVSSVVESSAGVTTSDASSAAPTSSSVATTSRPPTSSIESSTGPSSLQPSTDPITSSSTSVGPSTAASQQSSTSSSVEPSSSTSVQPSSSTSVSSSSSIEPSTSAVSTSNTATSTSSYSSGDSTSSSSNASSASKHSTSVVVVTVTDSNGSMRVTSSSIATGAVTDAGKSGSGTNTGAIVGGVIGGVAGLAIILALLWFFCIKRRRNNEEAFDEKTFDPSRAARHSVNDPIDLLSPSVPAVGGAAASGNSTPRVDPFPFQNPSPENPFDSYSHTPMHMPDARDYMGGAYDPYGGMEGGYGVAAAAGIGAGAAADHYNYGENAYSSSDYPSTQAPVSPTRSSSAALAKQREAASERRTSRTSSGYNVATGSGNGPQEVIGSPTESESGGRRESGYSEGRTSFYQHTDMGSLPDEEEEQLDEIPPNYNSISRPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLW0</accession>
    <name>A0ABR3BLW0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allergen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611250.1">
        <property type="nucleotide sequence ID" value="XM_066760489.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992897"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0241868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26836" checksum="DEEDFCF4F9A5D6BF" modified="2025-10-08" version="1">MSEPNTSSVTQGVKDFFKSTAKPDSTEVCTETAPEVVEEHIRPQEHTESVEAIDRERHIHHHQHRIQPIEHKQALDPKHVHVTAPAVVREHKEEMLPEHQETLQKQRTLHSNQQTTGDVEKSHAHLGTHVNQHEHHHIHETVQPVIQRETIQPTVVHHTAAIHEKVHDAPIVHEVTTLPTIGHNDFLKMKEGLKGATHADKGHQHQFYEGAPRVGSQQTSTANVASTTNAASNKEVPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM94</accession>
    <name>A0ABR3BM94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pirin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612282.1">
        <property type="nucleotide sequence ID" value="XM_066759635.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992034"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="3">
        <location>
            <begin position="33"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="4">
        <location>
            <begin position="194"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34446" checksum="88C78FFB85139AF9" modified="2025-10-08" version="1">MSTTAATSSATGTSRSITKSVYAHEVSEGAGATVRRSIGTRELRNLTPFLMLDHFRVLPGAGFPDHPHRGMQTVTYLFQGTFKHEDFLGYSGTLTPGDVQWMTAGRGIAHAEMPIFDPDPAKAEPVEGMQLWIDLPQKDKYIEPEYQDRKAEDIPVIRPKDDVEITILSGDSHGTSGSVTPVGGAWYLGFKLQKPGASVYQPLPEGYNAFIYIVKGKLQVGDDAKAHDKFNLLVLSAKPGESGVALTRPADDTGAEEAHFVVIAGKPLDQPIVQYGPFVTCSQRQAMEAIMDYQTGKNGFERAVGWKSKIAKDFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN15</accession>
    <name>A0ABR3BN15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_105917</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611670.1">
        <property type="nucleotide sequence ID" value="XM_066760366.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992772"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0242288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="450" mass="49649" checksum="5B0484AF9BA85621" modified="2025-10-08" version="1">MSDSGTLSLLVGIAFLVLWMIVWSICLLGWRTARIRYAHPNIPSRLSKLPVSSAPGVTIIRPLCGLDQNLYNTLESVMKLDYPKFEVIFAVQDEKDEALPVVNMVMEKYPEVEARVIIDSRKVGVNPKVNNLMTPFQEAKYDLLWILDSTCSVLPGTLGRSVEAFFSNKSSAASPCDPESSPLLSISDDVRKPPIAGEVGLVHQVPIAVCYQRTWGSLIEQAYLNTTHAKMYLAINATAIDSCVVGKSCMYSRENISHLATPSPSLRSLPDPPSGLAGFGPFLAEDNMIGLSLWHELKLKHAMTSDVVLDFIGALSVGDYINRRIRWIRVRKKMILAATLLEPLTESIISGLYGAWAISRLLGGNILPIFLIHMAAWISVDLSTKRALETNIKGIGPPENKVRFLMAWAARECLALPIWMLAMTSSEVIWRGQKYKIIASGEAIRLGNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN89</accession>
    <name>A0ABR3BN89_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Splicing factor U2AF 35 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104671</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612623.1">
        <property type="nucleotide sequence ID" value="XM_066759136.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991527"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="44"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0245539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25346" checksum="EA0410E6CE83886C" modified="2025-10-08" version="1">MASHLANIFGTEQDRVNCSFYLKIGACRHGDRCSRKHIKPQFSQTILLPNVYNNPGHTPEGQNMSAEELQADFDRFYEDFFIELAKYGNLQEMIVCDNVGDHLLGNVYARFEYEAEAARAVQALNDRWYAMRPLHAELSPVTDFRESCCRQNELGECKREGFCNFMHLCHPTRSLVSALQASQRVSRRRAQKGAEVDSGDMGWTPAVAAGGEGDLGWMPERRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNJ1</accession>
    <name>A0ABR3BNJ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611835.1">
        <property type="nucleotide sequence ID" value="XM_066759889.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992289"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="147" mass="16404" checksum="72388950EF6AA7DA" modified="2025-10-08" version="1">MAALPAHHRRQQIQEEDATKLQFGEFAEGEALTLTEVATLLKAARQAPNVPPAPDNKVYQSTTDYVNEFSNTTMDVSDSMRTALSARHGFLNKFEIAQIMSLRPERVEVAVALIPSLERYAQGDENEAQLQSLLDDVRSMVRYGVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNY9</accession>
    <name>A0ABR3BNY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612839.1">
        <property type="nucleotide sequence ID" value="XM_066759352.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991747"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="192" mass="20724" checksum="9CEB6787CAA4B180" modified="2025-10-08" version="1">MPFPSPHVKRTRSHSSSLSIARSPNVLASAHFLPPISPLSPHDLDRANANEIHHPFTQNWRANLLGRSVSASGIGGLAAIPSVEDLSASTTTDALLDPEDETGDYAEDEYDGSPSTPLIKPRARSLHAERSVFDRLSMDLDGVERLDVPSLEYTGPFQPPDSKELLVIILSFAGVFVLAVAAGMATIFDWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNZ0</accession>
    <name>A0ABR3BNZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612875.1">
        <property type="nucleotide sequence ID" value="XM_066759388.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991783"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="16"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0245791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="193" mass="19784" checksum="974674D22DD05AF9" modified="2025-10-08" version="1">MAPTKKTTTAIKKTASHPPFLAMIQEAISSHPTDSKKGVSRVSIKKYLEDKYKLDMSAASNTSNLNGAIKRAVEKNELALPGGPSGRVKLVAAAKPKAAEKKPAVKKTAAAKPAEKKTTTKAAPKKAVSATKKATTAKPTAAKAKAAVPAKKTAAKSTATKKVAEKKAPAAKKAKAPAAKKAAAPKKAASKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP08</accession>
    <name>A0ABR3BP08_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NAD+ kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612721.1">
        <property type="nucleotide sequence ID" value="XM_066759234.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991627"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="677"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="685"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="719"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="794"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="851"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="872"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0245637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="923" mass="102534" checksum="B2A41F1C093DA74A" modified="2025-10-08" version="1">MPDTRPSTPPPSSSIRVSRPPQSSPYLNVPTTARMRHPAAPSPLSKCEPTLENPRSISAMSSPDHKSLAAPSTSALAIPEASPCFIHSHLDRHGSLQDWLKNKSANNRPHFALDSPTSSKIRSDHGQHHHTNTTEPVLQSDVPFPSHQRQENISSPPSASQPSSPRENVPPTRKGPLFNGYDSDQSSMNEYGTRTPNLLTRGNLLGDGLLEGDEEGNGSLTRQLAETAQGVREMSKELGRTKVRSRIQNVLIVTKARDNRLIKLTRELALYLMQKHPAVSPDGSSSRHGNGSRDRGLVVYVDAQLQKSKRFDAAGLQRDYPQLFVPMARQRSSSSASVNTLSHISAFSSTTSMGEVAKQATNGEGQLRYWTSELCSTTPHLFDFVITLGGDGTVLFTSWLFQRIVPPVLPFALGSLGFLTNFDFYKYKQTIDKVVDEGIRVNLRMRFTCTVYRAVASGDVTISKSKKRKAIKKPGGEILMSRVDKGGWESLEGPTPAASPSDFEGEDKEIMCYSTRPVEQFEVLNDLVVDRGPSPYVSLLELFGDEHHLTTVQADGLTVSTPTGSTAYSLSAGGSLAHPQIPAILITPICPHTLSFRPMLLPDSMELRVCVPYNSRSTAWASFDGRGRVELRQGDHIKVTASKYPFPTVCADKASTDWFSSISRTLRWNEREKQKSFVVVEEASEPERSEDRKENAKEDLFDEGRAKTKFEKDAKGDGDLVESDEEEDDDDEIFDIDDKSGPSSPPVQQQQQPTKHEMFQRQLHSLLSSHQSGLETPNRFVTPYSAPPALSQRHLVEAIHKAEIQEKENEHGQRDNIRENPSSLRVDRSRRLSQLGRTTSQSTEETETEGVEQKEENLRREEKSPKHGQQEHHHHHHHHHHHHGHKPKGTALNLPENMAECKAKAFAFFGQDDSASDCSGSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP51</accession>
    <name>A0ABR3BP51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_104008</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0246976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612937.1">
        <property type="nucleotide sequence ID" value="XM_066758489.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990864"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="824"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="887"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="247"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1028"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1064"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1120"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1167"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1192"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1226"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0246976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1235" mass="136606" checksum="EFCE9755E7BC9C7E" modified="2025-10-08" version="1">MPSNQDVPLPFTSSRPLPIRQRTTSRPGGTLKRNKTLTRPERHVAPAPLVAPPTQSFSPTSPLPLSDGLLNIDWWRLWAYATTFWAPPALLGWFGIKEKQSRQAWREKIALCWIAVLLGAVVGFVTMGLQRALCPADQQNQSMYRRLGSTNMTLSISGWAFNISTSVTQSNVDFYALANQMPGQDITDLFTRSASDYPACTSSLAYAAGTFCNSTSSTSKTSCVLSTLSQGTFDSLQIQNTSLLEGYSWDQVAELENYMVIDGYVLNMSPYLSSNPTAIEGDDVDNIIRHVLSSQTESGKDATRLFFNRQVPHDAVGCMKARYVAGRIDKITPGCFIASLFLYASLVVILAVVLARFAMACVFNWFLSQKLVKPVTERELGRKGINPTIMPEGANVSVNNKLGTAPWAGTVGPAGGRGGRVGSGKKLMNGKKINPLSPLPSPPHSLPNAPLITLSQIGAELFTVCLVTCYSEGPSSIRGTLESIASTNYSDRRKLIWVVCDGMITGEGEKKSTPDVCVGMLDADGRFGNPVPMGYEAVGSGRKRENRAMVYAGHYVSKNGHRTPTIIVVKCGMPQEANEKKPGNRGKRDSQLILMNFFLRVTYNDRMTPLDFDLFRKIWTLMGVTPDYFEVVLMVDADTRIYPDSLKHLVNCMHHDNMIMGVCGETRIANKRQSWVTAIQVFEYFISHHHVKAFESVFGGVTCLPGCFSMYRIKARKDMDNDWIPILVKPEIVNEYSQCEVETLHQKNLLLLGEDRFLSTIMLRTFPRRKNIFLPQARCRTVAPDTFSVLLSQRRRWINSTVHNLMELVRVRDLCGTFCFSMQFVVFMDLVGTVVLPVAICLTFALIVNSIITPPKSFEEAIPLMLLAIVLGLPAILILITTRKVVYIAWMLVYLLALPIWNFVLPVYSFWHFDDFSWGETRRVEGEIRSKGHDDATAVFNGTTIPLRRWEDWERSRLRKLRREEKRRKEMERQFGVGFHGDPGLGGDRGMALRERPWARSEYDSDNGSLYSSEEDMWGGEVGGYNEHNPAFPPPPIALPPTDDSLSNTNGETLGMDEMAAILDSGFDDDPQSQSTYAPLSHPRPRAHQPPPSLSRTLANAPSPVHRHQHEYTAPQPRLNFTDSPSFDSSPNSIHSSPHSAGASGYTGGQYVSIDGQDKNDINAQTPYSGRSVSSSVESRPYGVGHAKKRSGGGPGLGTGPGVRSAGYGPLGPLADVDESEKGQIRGYGGSGKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP93</accession>
    <name>A0ABR3BP93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066759183.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991575"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="100" mass="10917" checksum="64E184BD8A19166E" modified="2025-10-08" version="1">MIKSANVQRLPAAMDRDREHEQASPSSSAALLSCYPLALINSQLALFEPRQSILGQILTSSPIPIVQPLIVTIYAAGKKLFNHQSDGSEWLRCDLDDPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPC1</accession>
    <name>A0ABR3BPC1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066758559.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990935"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="179" mass="19231" checksum="8036EEC5463D8373" modified="2025-10-08" version="1">MSTQSSPCRTPQYLTESFISTNRTGIPMPNLSLLDYDSSAEPDSSSPSFSLIQPSPSTRPTGGTSISSSVPRLSFARSRSSAFPIYNNQSGDDPGNSHYYNHSHDDDQVHEHGNSSTLFLKPIDPTVGPQNCDGSVHTATVNYQRLAANLSAKLHEEIMNAKWDDGANGGAADAGKRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPM1</accession>
    <name>A0ABR3BPM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612549.1">
        <property type="nucleotide sequence ID" value="XM_066759062.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991451"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052146">
        <property type="entry name" value="HOT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784:SF2">
        <property type="entry name" value="HIGH-OSMOLARITY-INDUCED TRANSCRIPTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="2">
        <location>
            <begin position="272"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="380" mass="41980" checksum="84BC72A13CA63C3F" modified="2025-10-08" version="1">MAHPLVLPMDEHAIPMNNLQTMPPSPSNSLNHNLSLAFSRIYDQIESLKQTQAQNHLQSLTDLERTVRLANAGIADQVRQAVNERMSGMVQQAVRQAVNENMGMMVQNAVRQAMQGIIFSIDYTDGNMQAQAQPLSQQRQQSQPAHPQSQPPNGAPNSNPTNVRATAQGWGMPPPVNGYMSAPNVSVVPGSDPNSSLPNTLHSSLYNFTHGSATTSTLPPNHAHPHQQHAHQSAPTPHGPSPSQPHMGLASTHSQASTSQTYPSPGSPNTGFTMSREIKTVPDLWREYTVGLEGQPPVRSVYEGSEKKRKKGKRFKDDSERKFYRRRKRVLDLVEVLIKKGIPEDQAAKRVERLREDRKVTLNKLGEIIPELSPEELAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPV0</accession>
    <name>A0ABR3BPV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612880.1">
        <property type="nucleotide sequence ID" value="XM_066759393.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991788"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="737"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="763"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1146" mass="115951" checksum="3A317B81E1658695" modified="2025-10-08" version="1">MTDLRASNLPTTISSYTTGATAQTGGFVQADNSSAPPSNSVFESGGGLASSPNVPKPGTSINPQTGKPHTAGLTRAQLEAQKAGEAAFQGGQTFAGPGLVSSATSSKPGPVANVAHDPAPDVDPTDATQAGALSTKELEAFKNKGAELLDPAPQTEQVRRGSISNVAKESKVRRPSDVSGREQAARQLAGLVPDTMETASAGSSTPGQELPGGWGAIKPTPLPGSGPHAPTSLYEDVTEGLGKMGQAAFSVIPSPIKDAFHGPGSPKGRRSSATGLIDQAKAQASKVAEGLQETIHNTQRRASANFGPDGTIRKQVMHFVDEAFQSTKDASSAEFGFIHSGPHGRVAAVPRVSHPTEELVGAQPGEHSDGVGALPGTVNETGVAILPDERNGTRFSLPSHELIGALNREHSSGVGALPGTVHETGVAILPEEEKVGHVRIHPDHAAGVGPRTSLPSDEYVGALPREHSSGVGALPGTVNEAGVAILPDERSGTHFSLPSHELIGALNREHSSGVGALPGTVHETGVAILPEEEKVGHVRIHPDHAAGVGPRTSLPSDEYVGALPREHSSGVGALPGTVNEAGVAILPDERSGTHFSLPSHELIGALNREHSSGVGALPGTVHETGVAILPEEEKAGHVRIHPDHAAGVGPRTSLPSDEYVGALPREHSSGVGALPGTVNEAGVAILPDERSGTHFSLPSHELTGALPREHSSGVGALPGTVNETGVAVLPDEKNLNASAPSATTTGSATPADNSYSLAPPLPATTLGLGAAHGATKLGPDETLTAPGSTTTTTLSSAATSISPEQKHFASETTHAHERASSAASMTAIAHGREGKPLDRGSSAKESKIAPSPLAESTVPEDKSVANSKETAGRAGAGAAAATTAVGAAAIGQKSTVPGTSSEHTTSLTPGKEEEGVGHPSTHNTAGTSREPGTYPKPDNVTSTKAPATTGVAGSKIGQHGVKGPNEPVDGTGTAGEADDLISHDNSAEHSNTPKPVKDKISDPHDKTYPSDREVADVPDNKTTADDSTKATNSSAAPGVEPTAEKLRTEGPTTPTKRTEIGSTNTAEGNTEAVDNKYTATTAGTGVAATGGAGTTEAGASSTTAPTHRSQASTDNPVSPTTSTGSGTSPKKKTGFMKKLKNKLTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPY1</accession>
    <name>A0ABR3BPY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613207.1">
        <property type="nucleotide sequence ID" value="XM_066758759.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991137"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="178"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="178"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="576" mass="64303" checksum="E004B9AD23590540" modified="2025-10-08" version="1">MDSFWMANGFVGLPDPIEDTHQYLSPPSSILSSEARSQSFNNQSNFPIHPYPLRTQRSTSSLSGWSTVTSDTNTTSDFDDDDSSMSTFPASHSPQSRLSGSHNQLCQSSPQSLSIDPKLFASMEMDEEADEESLVTAKPKELAGTLDPTMVLESLKKEKADNGKKKVSHARKKTADHIPRPRNAFILFRKHVVDAKLIPASVEMRHQNVSIITAKMWSDASAEQKAHFNELARIEKEDHMKKYPGYRYQPVYRRTNVVRRRVRKDEAEEEKCKNVAELLMKGKSGQELEQEIKEKVASGVTTGAEKDKASSRRPNGACELSKGALRALRAQARQRQQSFNSGDWSDLSRSTSIDPDAQGSRQRQYSAFEMTGSLQSPEPDDGSQYRLVQGQNQVPSGQLQYMAYSHQGLAPWSNDVPAELNKEQAFTFTSVQQDFQPDQQGPPTVSITSHTYPSTSRHFLYPQPQPQFQLTIMSDQQASNEFYAHDAALPFSPSACQFTFQDQSNSMHIDVMPIFDVGSTQQQVAHPPMSARWDKGHLLPPSRDVPLEGLPFDDGLILGDFEAALAHADDMIGGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ27</accession>
    <name>A0ABR3BQ27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613244.1">
        <property type="nucleotide sequence ID" value="XM_066758796.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991175"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05367">
        <property type="entry name" value="SPR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="26899" checksum="83F8F02E2EB78E2B" modified="2025-10-08" version="1">MSPVIILTGASRGLGLAVLRILLSKHNARVATLSRSLTPELQGAVDEYGADRVLPVQGDVSKPEDNAGVVKEAVDKWGQLDGLVLNAGSIDPVAKIGNVQLDALVPYVQTNLLSTIYLLQPALPHLRKSKGRVVLVSSGASSTGYQAWGLYSMAKAGMNSLARTVASEERENGVAIFSVRPGMVNMQSFLRTHGPAEMSPTDMAKFQGAYEKGELLAPEQPGSVLAAMAVNGPIELSGEYINWSDERLKAFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ60</accession>
    <name>A0ABR3BQ60_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_104362</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613287.1">
        <property type="nucleotide sequence ID" value="XM_066758839.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991218"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="11">
        <location>
            <begin position="87"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1117"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1177"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1117"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1140"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1153"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="191"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0247326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1196" mass="130634" checksum="81787DC680D46663" modified="2025-10-08" version="1">MSRRPTTSRAGMSRTASSASISMAPPSRIPNRPPSVMSVSQPSHERDDRDSRASSPPKRMRKGNGVTMTSRKIEAPGMGINMDGEINIQVVVRCRGRSQQEVDQASPVITTTTGPISKMVTVETTPLPSATLSTFTTASVYGGTHHPTTKTYPFDKVFGPEADQTMVFNEVAEGMLGEVLSGYNCTIFAYGQTGTGKTYTMQGDLELTNLDTPKSTAGIVPRVLHSLFNILESQADTEYSVKCSYVELYNEELRDLLAPEYRGEQSGTGGLKLYEDGKKGTMIQGLEETGVRNLKEALGMLDKGVKRRQTAETKMNTESSRSHTIFSITVHVKESGMQRGGEDMLRIGKFNLVDLAGSEAIGRSGATDKRAREAGMINQSLLTLGRVISALVEKGSHIPYRESKLTRLLQDSLGGRTKTCIVATISPTRSNMEETLSTLDYAIRAKSIRNRPEVNAHLTKTGLLKEYVGDIERLKAELAATREKNGIYIPEDQWREMHEVQVKQKSDYDEAKLKASVIEVALDTKKKEFDEISVRLLATVDELAQVREAEKQLMEMLDETKIVLDAIKTRLDEETVISQAYMQGEERLDAVAGGLKKVATESVNDVGGLFEKIARKAKILGSNASAATRFGGELQGLSQNLRNGLSQLQSAHENFGQEIQIEMETYALKGQQATQHDLAALDRSFVAFNDLSQKLASSNEKGQREASDLSKSLLAVKEEVQNSVREWAQGVSDRSKSMVDELFEHQQQHLTAVGSVLDSTTSLVDAIITAAQEHLAAESVSALHARDLAVQTSSSEIARLRSQNVLLAKLLSEEKAKTAKLRTELIGNLTSMIESFTDEQDKGWSAVVDKVKVDNEKSVEKMEELDEEARRVWEEGDGRRKLFENQVRSGGETAVLQKGEGQMALRQVREGLKERLESYGQETMGEAGTHVEMMDGFCVKMAKSATSVVNKSTARGKKNSEIMEALAKNAKSTHQASQARSSAMADSINSLTSTLLTSQSSSSATFSEAYSATESNLNSIISSTADFLQSGIQEDIPTGITPRKKVWNVQAEWERTGPREAVLASWRKRQEAEVQPESQSGVVRDEVVVNDGACGAADGVMDDGVSQTEFQAFSRENTITIPSRTSSREPTPTGIPPPSLISSTRISSGQTISTRSKLTKSTTGKKLGNEIVDEPRPAVTVLGEGGVNLPRRGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ83</accession>
    <name>A0ABR3BQ83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613307.1">
        <property type="nucleotide sequence ID" value="XM_066758859.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991238"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="598"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="867" mass="97916" checksum="4E76E9ED20249619" modified="2025-10-08" version="1">MSPYEPTTPPTPSPAHRQFVSLPHHTASQRYPFSRQIPSTRPSSASYSQYRDPDINASLSFDTDVVIETQSCMSEDDLNSRNDIESVIDADFDNQLADDEDDEVDIDTALQESVSLPQTPALFTGKKRARSWEQTPNGDGADEAEAEGILGWSVKKGKSRAMDRKPYKFAKRLSMSDNENMLPAQMGRVVSMGGITKGISDLRASSTIISMNVDIAHAHSAQGLAHISEAISSPAGCRVTSRRLKDRHNCSNKRGKRKRGARHFQQLTASDDPFITLPVLQNWKGLQRFNTEVSEMDVSEAETDGRYDSDATMKSASDIERSTIDVAVPRAVVKPDVRPRYEPEQPLSNKQIASLDRKFTRSKRGIQRLSRHRDFPIRAAGQYGTSQLRRTSPTSLLPARRIMTRRGSLRVPLRSSFRDYLDNIRPGADRRVPGRCEFTPVMSGELFIALLRAKAVARKVRRDAVKAYNERTKDGAWRAWVGNYALREFIPPVRQWWLEDLAPQEEEAAVENLLPAEETTEEPMSSLVDCTYESQSSTRKRARSQTPASESMPMEVPAPDRQVRRRVMVEPYNPSSLRRQRAHETAGRVREATQQSLLEMLNLEAERIARERDEEERLREEARLTEFRRAQEEADARVARELELEEAAINNGNGLEVESEDDELEESRRGPSPVITEASIRSDPPQYEPPSQFSGEHSVVISSIRHIAHRPRARTPPREPEQLPTYTLDRWSARSPPPPPPYNAQTDRQTIIAPRIVSEEETPRDDEVYHFGGIVRRRSSARGDPSPEPAHQIAGAYPGPAQQVRIIAPIPVRPLVDAARAFEAAVDLEEGEDVEREIWEGGEREEDEPRAFGALQRVLRFVWGRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQB5</accession>
    <name>A0ABR3BQB5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613319.1">
        <property type="nucleotide sequence ID" value="XM_066758871.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991250"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="643" mass="70841" checksum="DAAF7248D889A751" modified="2025-10-08" version="1">MNTGTIFEILSEDPYLEYQPVLAYTLPIQLVVNGITGTLLCVLLIHLLFTTQYHYPLAPLNYFLQLSSIVTVLISVIIKLVIILVHCTSQADVWPYSLDYVAVNVPPETWSTGQNAAWCLLQALNAGLSNVTHIQFLTLLYPSRTEARLIIFVLGPLALVSSALTFAALTNSQTVLDLSDAIRNVFNSTLLLIFTISLAIWGFFVNRRRAWRFDGGTAAFGVGSLFLATISTTFNFVAVAEDGIEWLQHLLFAAILWQIWLGWWWWVGSGMGIGEVEDIMAKAEKKKRKQAKSAARARAAAARDRDASRGLDARKRTNSFAGLADGFTSGVTSILRTSRAGTLTRRQTRRSMVDEGLAEEGAMELDDLGEGGRRRHASRASPIPRVSPLPGARNSNSANSNNGSANSPDPRVEFSRPEGAEPTSSSSGGGARNMQSTNSETSSTSATPSLHPPETIGQLFSYPTTWLVVYLRRLRKAHQEAAKKAAIERAERRERVFAEGHRRSGEREGGEGNSREIVARMEAAVAGGNDVGWGLGRFGIREHEESAKRLRRAGEMLDEDRLLGSTSRAGREGGGEPEGEWEDIVTTSSSNEGKRRKGKKRTGKSGNEDRDHEGEREDLRGQGSGWSWWGPLKDWRLNDRHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQL5</accession>
    <name>A0ABR3BQL5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_103528</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613424.1">
        <property type="nucleotide sequence ID" value="XM_066758022.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990384"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046617270" description="ATP-dependent permease" evidence="11">
        <location>
            <begin position="21"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="895"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="929"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="972"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1008"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1041"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1098"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1125"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="412"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="672"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0247463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1151" mass="125850" checksum="9594A167BE9224F2" modified="2025-10-08" version="1">MIRRLWLPLLCLSLPRPAAATSEEMLDHRDTTVPSSLLRTVLPSRRPSDPSRPPECPPCFNCLLPAFNCGNSGECNPYDGQCKCPPGFGGQDCLTPLCGALSDGDERFPRPKGELCECKDGWGGINCNLCKDDRACAAFRPRSEDAKETKEEEGENEMVCYKGGLAVEQNFQMCDVTNRKIKDTIPDNKPPQVTFSCLANSPSSNSSFTPNPFFPAFDDPLAGDAFGTCNFQFWVDRIESFHCELSGCNWESKGSFDTNQTSYQCEKIECACIPGRFLCGEDGSVNIDDFLSEEVKGPGSFSCASGRGCSFSEPAMNQLINDIFGDKSITLDCESGECLHYTQVPGYITPEKPDNRSLVALSAAGAAVIFILACLLFWYFGRTHRHPSGFGSIHLPSDEASKLMSDHVPATLHFNNLSYTLPSGKRVLSHITGTVRPGELLAIMGASGAGKSTLLDILARKAKSGKVRGDTYLNSRPITDGSTFRRVIGYVDQEDTLLPTLTVYETVLFSALLRLPRDMSYDAKVYRTLETMNELGILGIKDARIGESGKRSISGGEKRRVSIACELVTGPSILFLDEPTSGLDSYNAQNVIQSLHTLAQRYKRTVIFTIHQPQSNIVNLFDRLVLLAKGQMVYSGEAVKVKSHFEGIGYQCPEGWNTADWLIDLTVDAAGDHRGSRSGHHHGNGNGNMNGGARGIYAERNGHDGNTLDPEVGFPTTSHPPSSLDPDDSSSTSPVGGARSPGGVLAEIKAKAHNLLGVLIPPSSVPSSSSPTPIGSTTPSPRDTSASIATARVDHIPEKLASLVLASKASDDAKIVEAEISRIQHGETADGGYPHSHPTTTTTTISVSADTSIMADQRDVEEETGLMKGYQKAGLWEQFKLLSSRTFKNLYRNPLLMATHYAVAIIAALLCGFFFYQVTNDIPGFQNRLGLFLFILSLFAFSCLSSLGIFANERLLFMRERANGYYSPITYFLAKLLFDIIPLRVIPPFILGSIVYGLAGLNAEVSAFWKFIMTLVLFNLTASSIVLFLSVAISDLGVANLLGSLIMLYNLLFAGLLMNYDRVPNSLKWMLTTSFFHAGYEALLVNELRYLQLVERKFGLDIQVPSATILSSFGFHAQAFWWPDIALMAIVFGSFTVLSYLVLEFWVKERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQT1</accession>
    <name>A0ABR3BQT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612333.1">
        <property type="nucleotide sequence ID" value="XM_066759686.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992085"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="3">
        <location>
            <begin position="806"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0243966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="899" mass="99160" checksum="5C7B6D79297A1D13" modified="2025-10-08" version="1">MPKHDSSPYQINTFVFHPLYIIPDFSIYPAYNHKSPTLCSHRSSFVKPAGQAVSYIMPQRDSYSWYPPKSALALSPSYPRPPSGTSDFDNEDRPFQYSTAGPPTVYSELETVWSQPSHMQPRTAGFPVPPLPVPGPSKNNVISPESPLDGIEDDEDYKEDDVDDLYHRSDWEEEPKTSATGWSRSSWAGPTTGGTHLTHFSKLGGIMEDEEEWIPPVPTITPNQLMPQRPSAPPESVRYGGVEYAVDQGEVMDSPGEMTPAAYRDRDRNIMPSMIGARMDNDDEAPRNLSMAQRQSTLTSILDLDHLVKKPAAPPAVNDEQHIFNSYQTQPHFQSQDPFADSPTDDAPQDDQGLTRHRSPYAAQTTPDLTKTYNRGHGPGLGSSPKLLTPEAHQKLGRMSVATARYTIPPQRNPGKVLGLPFHNRNGVFQGAQGGSGTGTGDGAALGVWGWCVLGVDAPECETYNTGDFMNESGSFTIPGTATVSNLSSLLIALTTLTWLLASFQIVTAFLHFYLFFALSFPLSHLVSFPATRQPREEVDMRVKCERPPYEECLWVWWAWWGHRRAPVGWILGLLAGGLSLATFGVTVLFKRAIINGTGSNDVYYGMGAFMPLVTHFLTADTFISSVMYFVKIKSNISTLLNPPDPSPTVLMLPSSSKPMQHIRQTNGGSFFAPQQPTVMSDTGYTANLHDGYVAYGYAEEGTGEKVRFDADAPVPPAEPLDPETIRWLSAYPTDPELTSLISSLRANKLNDDFLLSSVGLLYLRPETDEERALLVPPMGVLRKELIEDAHLDPSRYSEQGSVGDLAHNNIEVMVATLGDTFWWNGLARDCQEYVEKCQVCKERKRKEKIEPQAGITPVPWTGVTGWTQGMTAVGESDMAAEMAVAMIKAAEQADKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQT8</accession>
    <name>A0ABR3BQT8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mini-chromosome maintenance complex-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612600.1">
        <property type="nucleotide sequence ID" value="XM_066759113.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991504"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="53739" checksum="B890A14CDAFB6A2B" modified="2025-10-08" version="1">MLRVEEILVTALKEHDYRDNNSVNVDEHIQRIKGQLDDSPSIRPYSKTSTPLSVVSFKCLLQDTGYPMEVYLPGNIETSGNVDWSNLKERWVGWGVEIPGEQAWAKGETDLSHGLQGLSIEPQPLPPSVHTKYPLPGQKGEYLGALLKVYDDASFKPASTHEFIGLLSYSPVPSNEPEEADIVPTIHVLSERQDAATHEVTSQDEETREELLDYLATAFNPPDRTAAEYLLLLLLSSPTTRPTSLPVLGTLSLNFRHQASSTTSAFNSVISSVSPRVVPLPLTIPLLHSHPFSPNMTDTTGLNAGLLQLGEGTVLVVDEDAMGDGGALSEKALGNLKALIECVKDQKVKYEYPYMDGLKMDCAIRVAVLSQGKKSLLPVDVDIPLREDGTAPTKTPALEAFRSYLARYSSPTHASRLIIPDETSQLIQDHFVQERKSSAADAEETLKRRMKVARIVALSYPHATLNKDVWERTVRLDQVVAKRHTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQY4</accession>
    <name>A0ABR3BQY4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613567.1">
        <property type="nucleotide sequence ID" value="XM_066758165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990538"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="494" mass="52730" checksum="91C87BDE3D4F8620" modified="2025-10-08" version="1">MAPQELILSAPSSASTAAIHLHDLLTSSSVHAFKPCTTAPYSLAHVPTYNSQGGAVFAVQEDKALLHVWAWQKDQMHLKLHLPEKMTCFTVSPNGYWAAAGSPNGHIYLWELSSGLLVSSHTAHYRALTYLTFTPDSRLLISTSLDSSVHVYLVSQLIDPEDPSKAGKPYGMLKDHNLAVRCVGLGRVAGSEGGRLWTASDDGTVKMWSLHPPFDLLCTFVLPAACTPTTLAVDPSERFLYVGTTQGDVYHLPLFRKRNVVGGNSAAHAAAALELEPQQDEWEAVGGGGATSAPIRTTGAVISVNNNNDAKKDASNAVTSLALSLSSTHLLVGTSAGNIQIHSLPSHQHLRTLSPHAGPVTHLSTLLRPADLVGGVGAKSDEIPIMEIKPLERLKSRAPREYHEPTILLRPPSSTSSIASLLTDLKPRRASPAAKLGGGGGHLAIDSSAGAEDQMAQLLAENKRLKAAFDRAEKINEKLWNKVMDVKLGTNGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR21</accession>
    <name>A0ABR3BR21_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SPF27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613601.1">
        <property type="nucleotide sequence ID" value="XM_066758199.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990573"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="130"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24400" checksum="878BC75EEAD0C7A0" modified="2025-10-08" version="1">MSSTSYLDALPYVDKQVEDPVNKAAAQALVEAELRLTPQIAEDDHRLAASVDVFPRSKHLEELLADYPNKPIRGIDPSKYQPPIVDANATLEELEAAEKQGRIGEGYMGLRLENTSILSSYGPNAWLVRNYQLNSQLTELQATLAALKERVTDINRTRRTFQEETGQHLHRLEGRWQNLVGSAVQLELACTAMEGEVKSLEAKKIILQGEITELEAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR24</accession>
    <name>A0ABR3BR24_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104348</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613273.1">
        <property type="nucleotide sequence ID" value="XM_066758825.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991204"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047404213" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="11">
        <location>
            <begin position="25"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="12"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="482"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0247312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="520" mass="56392" checksum="825AED7B4673CB82" modified="2025-10-08" version="1">MAPRSSKKALTLCLFQSLAGVIFGWSNSEGSGLFSMSKYQERFGECVDGICTLSTTRQSAITGLLSVGAVIGAVGSGTVADRFGLRLTCLVFIFIYLCGAAIETSAVNTYGQICVARLLTGLGVGATSGLVPVFQAEASPPRYRGLVTGSFQLCVTLGIWGVAMTNWGMSSHAGDVSWRIPVSLQMVWAALLLVGFLFSPESPRFLAKKGRWDHCRKNLASLRGLPIDHPDIDIEMEEVREATIKDQERGQASYVECFSTKDRILWRTMIGICVQIGQQITGVNFFFSYGVQFAQTAGLDDTYVFQIILASVNVLFSFPGILAVDRAGRRPILLIGGLLMFIGQIVVGSVSKAYPDDKVAGDVLIAFTCLFIASFASSWGPIAWVVCGETFPIRLSSLCVTLGTGANWLFNLIIAFAAPQIQARIGTGITFVWAGCLALSVSFAFFCIPETRSMSIEAIDALYLSRTPAWRSSKFTEEQAAHVQRANEKHYSRSLHAENEQAKSSQQTSARTSADDDRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR91</accession>
    <name>A0ABR3BR91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial adapter protein MCP1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612483.1">
        <property type="nucleotide sequence ID" value="XM_066758996.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991378"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039960">
        <property type="entry name" value="MCP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012472">
        <property type="entry name" value="MCP1_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409">
        <property type="entry name" value="MDM10-COMPLEMENTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409:SF1">
        <property type="entry name" value="MITOCHONDRIAL ADAPTER PROTEIN MCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07950">
        <property type="entry name" value="MCP1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial adapter protein MCP1 transmembrane" evidence="2">
        <location>
            <begin position="123"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="286" mass="31594" checksum="E5FCF1660392DAF1" modified="2025-10-08" version="1">MTDHSPSENGGTFLCLPTRGQLLRALTLTQNTSAMAFTIFLVPHLASPIVAAFAGLGGAEKTMMIARDLYLPLEPILVYIPLTIHLFSSLSRRLLLSTSTFLPKFIRFPALPHQILAYPLALLLIPHIVTHRLIPSSSAPPIRELSPSELGWEFVGYNLKSWGAWIAYLGLVGAGVWHALVGGMKVATWLKSLWRRPTKGFSSNVRSTNRTVYPEDKEKASSDLIPRVIPKPRKLGLRGLIVVLLGVVSIGLARVTRDTGLVSGMMKKRYDAVFDATPWAKLYRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRB7</accession>
    <name>A0ABR3BRB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613687.1">
        <property type="nucleotide sequence ID" value="XM_066758285.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990660"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="149" mass="15600" checksum="C0FC764820E23425" modified="2025-10-08" version="1">MSNFERLNKTGDAILLHDDSQGPGVSAENPAGVYPDVGGNPAPPGSMPGSGAPDHHGDVRGVFGNPEVFKDTFGHLSSAFSEAISSIQHESGSGIGYVGKALIARLEKMRDEVDGWRTGKGLPEVEKHGGERGEDVEQAEGDEGGLYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRF5</accession>
    <name>A0ABR3BRF5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="13">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_103826</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity. The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="13"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613709.1">
        <property type="nucleotide sequence ID" value="XM_066758307.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990682"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="16">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="411"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="540"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="966"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1074"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="647"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="966"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="989"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1088"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0247748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1132" mass="126544" checksum="C572DDEE083E10DE" modified="2025-10-08" version="1">MGVPALFRWLSKKYPKIVERVKEDTPKKIRGPDGEIVEEPIRYENPNPNGFEVDNLYLDMNGIVHPCTHPEGRPAPETEEEMMVEIFKYTERVVNMCRPRKVLMMAIDGVAPRAKMNQQRSRRFRAAQEAADKEEERKEAVKLFEAMGHTVSEETANRKSWDTNAITPGTPFMDLLSISLKYWVSYKLTTDPGWKDLKIILSDSSVPGEGEHKIMDWIRRQRSYPTWDANTSHVIYGLDADLIMLSLATHEPHFRVLREDVFAQSSKGPPACKNCGKVGHIAANCKSDKKVKDPNVVEVAKTEDPKPFIFLDVACLREYLAIELVVPGVPFPFDLELAIDDWIFMIFFVGNDFLPHLPSLEIREGAIDVLLKIWRAELPRMGGYLTNHGKVNLDRAQVILEGLAKSEDEIFQKRKGDEERQEHSQKRRRIEEHKRQDEDKAREEGRNALTLNGTEYVAVDNPAATARGGPLHPSLPSRPAFDLVPKEEAAKPDDQQQRAKKAMAGSNSDIVKNRKAIRMANMSAAQALKAELEGSDDVNIDDKKAIAQEGKEEDEAVVTVERTEDEEKEQLTKEEARGILEEQGEKEGVDEEIVPSAIQTDEDEGEAPVGDATMAENDDSVTTNDDEDPTHVPRKRKRSDSDGDKESNEEDEADDEDDDDDAPPNPEADQPIPKKKLKVNADGTVDYEDDIKLWEPGYRERYYEKKFGVKLSEREFIDKVTKSYMEGLCWVLEYYYQGVPAWDWFYPYHYAPFAQDFRNVGSMDIKFETSMPFKPFAQLLGVFPAASRIHLPEPLQTLMIDEDSPILDFYPPDFEIDMNGKKMAWQGVALLPFIDQNRLLTALKSKEELLSDDEKRRNSWGDNVMFIANENPLYDVFCDKLYGLRAKDVSKPIPIDTKASYGMTGSVLPDPNCVPASTFDTPIPSISECPDLNPNDSISVRYYFPRQAHPHRSILLRGYRSEPARLTESDKDWVRRGGQGGRRGHRHGGGGNGNVTGGPGMARGRYESGPPRTNGYQQPPPRSNYGGGSGYGYGAPAPLPSRPPISSYGGGAGGYGYGNPYAAAPNPYAGGYGAPAPYAAGGYGQRPYAPPLPPPSPYSAPPPTYGRPPAGGYGYGAPPPKGGGYNPYTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRJ9</accession>
    <name>A0ABR3BRJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104329</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613254.1">
        <property type="nucleotide sequence ID" value="XM_066758806.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991185"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046660991" description="NodB homology domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="10">
        <location>
            <begin position="39"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0247293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="197" mass="20464" checksum="16DC8737D1806B95" modified="2025-10-08" version="1">MKFISTLFATLAILSTASAFPTMKKPATVESIDNCSQQGAVALTFDDGPHHETQVASDFDDAHKLQGADYGPPRRGGAGGGGGQGGSGARRGARGGAGGRGGSSSRGGVGWQGREIIVGACICDKADSTRALYDAGHTLGSHTWSQADLTQLDEAGIQGRDLVLLVYSPSARFVKPFKVKDAFLKILGVKPLYFQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRP4</accession>
    <name>A0ABR3BRP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613498.1">
        <property type="nucleotide sequence ID" value="XM_066758096.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990461"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08570">
        <property type="entry name" value="GDPD_YPL206cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805:SF1">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="66"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="373" mass="42457" checksum="B4C9CA46CE54F127" modified="2025-10-08" version="1">MSTTQSTSQLPVSRPDPTFQTPALTPSNSVGPSPAFTVLQSPAVSEFDLEDPFDKIGHQDDETTMPECWGHRGASASFPENTIASFVEACKAGADGIETDIHMTTDDVLIMFHDPELHRTTDGEGRIDKLPWKGVLEHVRTLEKPHQPIPQFTQVIDLLLQPENSRVKINLDLKVENDPVRLFGLIKSVVESYEGWQQKLAPRIVLGIWHPKFVVPATTILPYLPRYAISMDIPQCRKYFFSICHGFSIRYEALATSEGAKFRQECKAAGKKICSWTVNDPEEMRQCARWGIASVISDKPDLWRKIRLEIETDRAKALKPTLQSYISPFFQKKNWWFDYQRLAKEETEYLEREAGTFDIPVPHVEMHIAAPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRP6</accession>
    <name>A0ABR3BRP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_103929</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 8">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613812.1">
        <property type="nucleotide sequence ID" value="XM_066758410.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990785"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="11">
        <location>
            <begin position="10"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="12">
        <location>
            <begin position="308"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="13">
        <location>
            <begin position="478"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="588"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0247851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="659" mass="72438" checksum="2D11918ED7819607" modified="2025-10-08" version="1">MPRPTYTEALLGPEVYRKVRETKILVVGAGGIGCELLKNLVLVGFASIEIIDLDTIDLSNLNRQFLFRKPDISKSKALVAAATARHFNPNSGININARHGNVKDSVNDLEWIKRFGLVMNALDNMDARRHVNRLCQAAGVPLIESGTAGYLGQVTPMIKDVTECFDCVPKPTPKAFPVCTIRSTPSEPIHCIVWGKTYLFGKLFGEDDEDMDTEELDKAKASGENAEEIENLKKEAAAFRQVRKSLGEEDGPRRVFHKIFNEDICRLLAMEDMWKKEGRVKPVPLDCDAILNGTFVTPPLRTAPTANQQANSDKGAERAKNKPAALLKDQKELSLKENLELFLDRLSARVLAFPDTPLSFDKDDDDTLDFVLATANLRATAYGIPNKTRFQVKEMAGNIIPAIATTNAIIAGLIVMQSLNILSRIHSTSNGDSSNDSSDVPVRNVFLRTDPTKPLGSFVPQHPDPTCSVCRDVYIPFKADVGKCTLGQFVEDVVKGWLGSAEFEGEGEGEDVEWTVFEGGRLLADPDFEDNFERTLEDLRVGRGKILTVRDEDTNYRPVHFCVCQPEPEASTAYALPVERPTIPLAPAKPEAAARESSEEPAIVEHVPAKTAPNDMPSVTAGVKRPAPEDDGQAAAGGDDPKKRRVTTVMDDDDDFEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS23</accession>
    <name>A0ABR3BS23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613904.1">
        <property type="nucleotide sequence ID" value="XM_066757520.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989874"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0249717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="157" mass="16540" checksum="5DFCB666FD8C4812" modified="2025-10-08" version="1">MPAPVSKTFAALRNAPASLPLSPSVKALKISFVAKNASPGPRQFLRQHAPALAYANPLLPIAIHRIPDPRSKHKDPNSPDRDAVKLGRWGGVPDGLQLGSGNVPGGEMVVEFHNAPAQTLPLAHLSGQQILDQLLAVAVEKQVPRVAGSEAQKQASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS50</accession>
    <name>A0ABR3BS50_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613967.1">
        <property type="nucleotide sequence ID" value="XM_066757583.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989938"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0249780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="384" mass="43086" checksum="632733CE745D7281" modified="2025-10-08" version="1">MSPLEAYHSFLLSNLSAVQTIESSISNVTWLLPGRFEDAEVASEGLYALLSLVAGHHDKILSSHLSSSLSLPPHPFAKPQTPTEPLSAPHEPTTTRIHPVLPPPSDHARYTRYWTDNSSLYEKASRALSTISYLELLVEMVARKKLGDRRRWRVVLGLESIKTFLRLLLMFKTRRPVLYQPTPQREVDLASLPPELLNPSSSQQQDGNSPVTPQLPAYSPLRSHLYPMAGNLPEKYLQHPLDLIPQLKGSEYVAEAIACCVGLVRVFLLIRVSRQGVSRPYNQFSLPTLSRSMSPYLIPLALLLLSRRLRSKGESPLLMSHYAQQDKKLALQAFMAGPMWIGWTRPKIVSVAKTLERVPILGLVGDLVEGYLPLVDDYFFYTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS56</accession>
    <name>A0ABR3BS56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">I308_104199</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IND107</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613125.1">
        <property type="nucleotide sequence ID" value="XM_066758677.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991055"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046409">
        <property type="entry name" value="PDC10_dimerisation_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048288">
        <property type="entry name" value="PDCD10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20929">
        <property type="entry name" value="PDCD10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="19">
        <location>
            <begin position="15"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="19">
        <location>
            <begin position="144"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="316"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="720"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAL0247164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="812" mass="89252" checksum="7CC118AA46B08563" modified="2025-10-08" version="1">MGQATSSLPSSLPDLALHCLRVADMSPADGLVEPYFDYLIDVQTPSINEPTGTPGASEGGRGSSSEVGEALRPDVLGRILEENEGKQIGLRVYNTKSQRIRDVYLTPSRVWSEEESKASGDPNAKPSLLGLSLRVCNPAHALESVYHVLDVLEGSPAEMAGLVPWGDYVLAWSGGPLHSENDFYNLIEAHVDKPLRLFVYNADLDNLREVVLYPTRQWGGEGLIGCGIGYGLLHRIPRPSTPPSEPANLSGADGYFGSDDVRRLSMQGSQLLYITLVQQRHNRPQTSTSTVSCINKMSTYSQNNPNNPHADPELFYVRQNRIGKGSFGEVYQGYDKRTSLPVAIKIIDLESAEDEIDDIQQEIQILSQLDSEFVTRYHGSFLKGSHLWIIMEYCSGGSCSDLMKAGVFREEYIAILARELLRGLEYLHEEGKLHRDIKAANVLLTANGEVKLADFGVSGQLTATMTKKNTFVGTPYWMSPEVIKQSGYDHKADIWSLGITCIEMAMGEPPYADLHPMKVLFLIPKNPPPQLDDRFSRPFRDFVSLCLHRDPRNRPTAKELLKHKFIKTAKKASYLTELIENYEKWKAEEGAKPADDGVSGMSQEPAYGPAVDALWDFGTVRNNLPGTVSRSTGRPLPPANGSVNGPSNSHMSIHSTAPIRTKAEEFLPPSLTGRALPTTPSCGTATSAYANFPGHSQGNLTPTGTRNDGQPMYSTVKGTVVPPPAPAPAPSQTQPPHRHHNEQLEENDDDAMLEGVIIPALSNLATRVPNDHARSTLDRLRDAFIEAERSIPGVTSEFVLEIVENVEQIEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS70</accession>
    <name>A0ABR3BS70_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613986.1">
        <property type="nucleotide sequence ID" value="XM_066757602.1"/>
    </dbReference>
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<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
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                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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                <person name="Gnirke A."/>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </source>
    </evidence>
    <sequence length="1472" mass="158534" checksum="E3FA48A8F3922AC5" modified="2025-10-08" version="1">MGILTRIRRRSSLAAQTQHLSSSSPLASQPVPSSTLSTPAIAPDSTSIGSMGSRIPKKPWKKKHGEGSLNGSSNKKGKRKTKGENDEVLGGPKYGDFPTSLGPTSSPSVINAPTAHTDGPSSQLSLSPPGNGSLAGGSNSVPDSSKKIEKRRSEASEIIRPSSGILKQDGGILGKLNFEDEGDRKRKMSNSSWMKDVEGLASSGSPSERQNASISNFIHPLESSLVVTSSSRAITPDPNSDQRQPLVSTASGGSKREEDPVEILESAEKKHRFWKSKGKSNRHSRVMSDSFQLDRSESPIPGKIPSSSTGPDLASISRNSVDLDQPHPQQLRRPSSSFFSNPFHRSSSRASEIPLAVEDGSFQLKGFRHVSGMSDVEGAGQLEGYLSHVKRESVAVLNIELPAAFTAPNSPVAYTSPKPTAIPLSRPASVTHSLTSVDDMVSPNRVSVAAFKKGLRRQSNGPMSTMSDMGHGTPVSGSGDEDEDVPLGKRIVSQPLPRPTSSPSLSYIRDLSLSSQEGIASNLMLKQLEKQTSEKEVSSQEPLAFQAKAYSRTSSGFVVKSRSPMASNQDLLSSPVSSLNSLAAGFPVSLDPKVLTSTAPARTPSANVGVINLNEALPPSTDNKELLTDGYFSAGAPSSDQVMQRIQEFPPPIISQTTEELTKVAIPPPLSTSQQPSVTSIPKLSTYVQSSISPPKQPTPPPAQHIDVPQASHDISPTLFGLNLPLPPDQMPDTPPKVPVPLSELPRGPGSSSEGPASPSTQRRRMSLFEEPMKYLSGLWVTSPSGEDGFDPVFAINSGDEPQSPTRLNRPDITSWYAPQDLPKRQTSVSPPPLSPAGRIRSPLSERLAGVATSAISTTKPGRGLQKPVMEKLKTSVEDLSPSDNHKSPVSDFTEASISQSGPRPFSSFIKPGPVQSKLATDESESDTEGGASVSTHQRQVSRTVSLASQQSVRRIPGGPRQPMRQSRIVSLPITNSHLAQKSHEHRRHAEKDANEDEPLAKIKHRSSKSSLTTATAAKFPSYGQASLPTPPTSVTNTSISSSSPQERRKPLIEFGPAAPGQSMMTPRPHDSVLSAPSSPFDKFSTPFTDSMTTSGKGSLPSPISAQVRFDSPERKRPSGIPRKTMSPETSKGNVNGNVIEVHDERQRQQNDEENSDSRQRRRSDGALQHLSPYDPPVQARMGMQGMPNQQDMSSEAFLTWQKHQWQMHYLTAAYRASEEEWQRQSSVSMSINNHPSTQSAPFPMQHMHMFPPNMNMNMVNMGMGMPMGYGYPAFPQFQGHMFNSYLDMPQMQNQTGGGGGYSYGTGTQSVFGGGFGPPPAIPSAVPSAIPSQQRQHNPQRRASSDQQGAQYTNPPHSHRRQDDPHSTKGRSASALGMHSTANSSPTMSKRPSSVFKGLLGEREKVELQQEMARQAQEKLDKQNQWSKERARGEATEGRSPPPPSSWSRVTGDLSDCATPRKPSRSGTTVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSD2</accession>
    <name>A0ABR3BSD2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613780.1">
        <property type="nucleotide sequence ID" value="XM_066758378.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990753"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="791" mass="84173" checksum="167D800F7603E888" modified="2025-10-08" version="1">MISIKLSHANALLFTSVHRGTPGSAVVDTLHRPRSLLSPVSFSTMSKSASHPPRSPSSPAQMGSLAYSARSGTHSPLTDAFLDAKAQSARRITSYENNRARAGSSTSASLPAVPENRQNAQPAPQSKPPSSYKLADKRKLPRTGSGLSGDRGRRISGGLDSDDGVLTMNRTRSYGKGKEKEALTSGMWGIPKEQIIKKARWVLDPTEMQLGSETWSNSLRVVLVLGHVTVEALEPMLYNPAFANTLLLIGSYKPIPEIDALLSPSYLLSSSPERAICPTLQPFQPSCKASGTDAHDLTVLLNQATILAKQYRAQTLPATRSRQGSFSSSSNSPPSTPGGKRKVLSGLGLGKTTPPRRGSLDSAEGDRPSPSTSDGERPGIPSSRSSGSLQAPNMVSSRSSRSRISSMSRDSFLGGMFKLDSDAKSSGEGPHLFDAVINFMPPMSMFKPQRAMQDMLHQAVVITTGCVPALVRHVGGKTSNDTLPITLLHVLPTQTPPALAPVLESFVLSLLPSFQARCSRELFGCTVTPSVWSSPFVSMSSNAITEDGVSGAEVLLVGGVRTLHQIMRAQGRAEEFKPRAFLYSWESCLSICGVIAESRRPSETRKSPTSTSKSTSASRSVSRQNSPGDPPSVNFNDVLARTPPQTSEHFWPTASAPNSYQPPSLLSFQPSSSPKPALRAPALPPIQTQNQHQRKSKLSVVTAASDRPNSPPTPDLDPSISSCSSSFALGETNSQGSGSGGSTNAAATGNGSDNALKPALFVPFVNDSYFIRTFSLNTSTTDIQHMLSILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSG3</accession>
    <name>A0ABR3BSG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614054.1">
        <property type="nucleotide sequence ID" value="XM_066757670.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990026"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0249867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="199" mass="22198" checksum="8B34189A091A3DBB" modified="2025-10-08" version="1">MSGKPSLGKGLPSQVKQSSQGRREPSGGAYTMFTPQQIKQFKEAFTMIDQDGDGRVTESDLREMLSNLGQTPTPELLHSLLTSRPGGSATAQSKAVNPSDGVNFTQFLSMMAERLIQLDPEQDLVDAFACFDDGDKGYVDVKTMRKYLGELGDRMEDWEIERLFSGPFTDRQGRFNYPEFAKVLRVNDGDPERKDKLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSH9</accession>
    <name>A0ABR3BSH9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614104.1">
        <property type="nucleotide sequence ID" value="XM_066757720.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990076"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0249917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="235" mass="25484" checksum="274E3122C18D5C33" modified="2025-10-08" version="1">MARSKPLAPHVGRLSRSQVAAKRGLFKGQKTGTASAKTETPAFTEKKVGGKANGEKRLVPTNKASKYYPAEDVRKPKVSRKTPGKAVLRSSITPGTVLILLAGRFSGKRVVFLKQLDSGLLLVSGPHKLNGVPLRRVSQAYVIATSTKVDISDVSIPESINDAYFAKAKAAKASKEGEFFGEGKEKKAFPEEKKAEQKAVDAALIASIKKVENLSKYLKSSWGLSKSDRFHELKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSJ4</accession>
    <name>A0ABR3BSJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614119.1">
        <property type="nucleotide sequence ID" value="XM_066757735.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990091"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF2">
        <property type="entry name" value="AFG1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="184"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0249932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="727" mass="82269" checksum="B73EB241DADA88F4" modified="2025-10-08" version="1">MIRTNLLRAAGQCPRPLSSKPSLSSGAKTSSSISLLSVTQTFSCIRRHIHCTPLRNAGPLYEVNLNQGHPGNTAALPPAPTDLLELYRGLVAAGRLNWDDEQVRCVMKLRHLLDTLSDYSPPLELVAKLNPSAPYIAQQKEQTSWWNGSKGTGEHLGFGETNGEVEKRLVKVLSGEEELANLKTPKGILLTGPPGSGKSLLLSLFYQLLPISKRRIHYHAFTLALYKEVFAEMNRRKSSDEEEWERKARNKELAGRKGWKSVFAGGRWDEEGKERPVWAKEEGVAFNIARRMILEYTVLYFDEFQLIDASSAALIRDVLSWYWRLGGVIVTCSNRVPEDLYHHGVQKERLAGFLDALKARCEVVQVDGGRDWRRDIEKQDQARWFHSTHGHDFERAWSAVIETQGSKQKQIKVYGRTLTIPQAAGNTCRFAFSQLCEEALGPADYLALVSTFSTFFIDEVPTLYLRHKNEARRLINLIDALYESRCQVFLRSTTTPSTLFFPDALNLSSQEEETLTNERMMSAESLSATIQVPYRPNVSYYNNLSPAQRDREAAEEKRKGTSFSVLGIWTGEDEKFAYKRAVSRLIEMTSSPSYAAEEWAPLEPTLRSWKDRPHLPDDASKTHKLLAESSSYEVDDEANIDRDCHFVTEDCDSYRHQLSNEEERKKLFKKDGDRRTPTPINEQHIWGVVDEWGEKAGRWGRGVGVFSPDPAASRVPCSCGKEKSCGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT04</accession>
    <name>A0ABR3BT04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_103385</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614267.1">
        <property type="nucleotide sequence ID" value="XM_066757883.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990241"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="295"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0250080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="592" mass="66567" checksum="D9627E17A1FF0CD0" modified="2025-10-08" version="1">MEQAQDVVSKLASTVTDTLKLSEDRKSDLPVVYIDEKTGSDTEGTGAELSPFASPLAAYQSFNPSPEADANPSSVATFMVRKADSVERNDWVELSASAKKKLVKSIGGWRKAEAKLAAEGERLEKQRQEQAEKDRLRREEAKNVVLVDDPSKESKSTKIWAVPELVDKRVRLQGWVHRFRPQKTNFFVVLRDGSGFLQCILTGDCIRTVDALDLSLECTVEVVGTVEKVKEGQTAPGGVELAVDYWRIIGKAPTGAEAIESRLQPDTDASIRADLRHLELRGEIAASVMRFRALFLRALRESFNKRRITEVTPPCMVQTSVEGGSTLFEFDYYGSKAYLTQSSQLYLETVLPSLGDVYCIQESFRAEKSLTRRHLSEYTHLEAELVFINFKELLDHIEDLICDVIDTLLADPVASEIIKTLNPEFVPPQRPFVRLDYCDAIKYLNEHGIMREDGEDHVVGDDIAEAAERKMTDQINKPIMLINFPKALKSFYMKALEDAPDFTESVDVLVPGVGEVIGGSMRISDLEELMAGYKREDIPADPYYWFTDQRKYGTAEHGGYGLGVERCLAWILKRYTVRECSLYPRFMGRATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT55</accession>
    <name>A0ABR3BT55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614317.1">
        <property type="nucleotide sequence ID" value="XM_066757933.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990294"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044986971" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="22"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="626" mass="70644" checksum="5AE6D2F78F872D5D" modified="2025-10-08" version="1">MILRSTLTALATLLSLSSTAAFYLPGSAPRDYLEGEKIDVVVNTLTPMLNSKLKSLISYDYYDSRFHFCSPEGGPERQPESLGSILFGDRILSSPYEIRMLENSTCQKLCQASVPKEDAAFINERIREDYGLNLLIDGLPSSEMRRDSKTGETFLDAQGFNLGDDELNPDKPALNNHYDIYIQYHMRDEDHFRVVGVLVYPSTVNSMVAGSTEPDCFNNQPFFLSEETGNEFFYTYSVSFLESNIPWGLRWDAYLHVFDPRIHWFSLINSLIIAGFLVFMVGMVLLRSISRDIHRYNAVDLSDEVQEDYGWKLVHGEVFRLPQRPMLLSVMVGNGIHLIMMCIVTLVFALFGFLSPSNRGSLATVLLICWTFFGCVSGYASARTYTTLGGEQWKTNLILTAVLFPTVVFTIIGMLNFFLIFASASGAVPFGTILAVLLLWFLISAPLSVAGYFYGMKHGAFINPVRVASIPRQIPPKPWYLSTWPAAILGGILPFGAAFVELYFVLSSLFGNRAYYAFGFLFLTFVIVALTTATVTVLFVYFLLCAEEYRWHWRAFLIGGGSAFWLFAYGVWYWASRLYLNGFTSVVLYFGYLFLVSLLDFLVGGSIGYVATYFMLRRLYTSIRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT62</accession>
    <name>A0ABR3BT62_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614331.1">
        <property type="nucleotide sequence ID" value="XM_066757947.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990308"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="167" mass="18653" checksum="0E9FF2F464435C3E" modified="2025-10-08" version="1">MPDVKQDDSPMKKDDNPLPNVYLKISINGKEAGKMVIKLYDDVVPKTCANFRSLCTGKKPDQTPLPPSFTYRSTPFHRIIPNFMIQSGDFERQDGTGGISIYGEKFPDENFEKKHDKIGLCEWLDGRHVVFGEVVEGMDVVKEMESKGNKEGKPSKDKVIISACGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT63</accession>
    <name>A0ABR3BT63_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614330.1">
        <property type="nucleotide sequence ID" value="XM_066757946.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990307"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="327"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="621"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="806" mass="89477" checksum="E05DABAFDE0203DE" modified="2025-10-08" version="1">MKFPYSCSYLTLLISNILQHRESRERSENMDYTSVRTKHRAEHLAREAAAASHASYYAHPALHVHTYLNKSNPAVVTQEGNIVGALNDPVQPLAQSSAPEAGGEAPPTGAPTDPGEHVHNIPRVNANTDEARKVGIEGTKEEEGGKEDAGVPSGIDKGALEIGGEAGGTKTSPGPTAEEVARYTPMIGDRTNGAALSLPNGRPDMERHLSVSGEMHPHLQLMCGPLLAYYTVRDNIWQGAAMVVIRDEGSVLDRPPYLNLSFHPYTPPSAEKPTLHDPEVQLLPPTTLGSQKIFTYASPEGNMSFHRFIMEIPLQPVQMTVRYSLNGGAEMDFVVPALSQNMRWAAHSCNGFSSGVNPDDFKGSYPSGYDPVWEDLLLKHQEKAFHCMVGGGDQIYCDAVTREPELQSWINEPTRKSKLGHPLTDDMRIAIDRFYFNHYCKIFRSNAFGRANSTIPMVNMLDDHDLIDGFGTYDDETQSAPVMSFVGSRGYFWFLLFQLFTCDAFDGVNPVPGTHAIKSLIIGDKNGPWIPFPSHSLLVYLGPKVTLLALDCRAERKLSQICRPESYSKVFNEVKKLQGIEQLIILLGVPIAYPRMSFLEHFLGLKWNPINILARHNALGLGSMVNKFNQASELLDDLNDHWCANTHKEERNWLVLECQGLAKQMHARITFLSGDVHLAAVGCLFTKKKKGGKALKPEQDWRYMLNVITSAIVNTPPPAGAAKMSCQFAFESIMTDYKDTDEHMMPLFDKDTDGSTLSRTFVQPRRNYTIVEYTPQSELIFDIRVEKSQGAGETVGYRVTAPAPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT81</accession>
    <name>A0ABR3BT81_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Calnexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_103468</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614347.1">
        <property type="nucleotide sequence ID" value="XM_066757963.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990324"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="231"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="61049" checksum="3267828BF99AB359" modified="2025-10-08" version="1">MRPQNVAGVAGTGALIMAAGALADRAVFHPTSLTAPFIEQFLESIPESRWTVSRATKQTPVGDEIFSYVGQWEIEEPEVYPGISGDKGLVLKTKAAHHAISTLFDEPIDPKGKSLVVQYEVKLQKGLECGGAYIKLLTDQQDQGLRAGEDYTDKTPFTIMFGPDKCGSTNKVHFIFRHKNPLTGEWEEKHLKNPPAPKITKTTALYTLITNPDQTFEILINDESVRKGSLLEDFDPAVNPPKEIDDPEDFKPESWIDEAEIDDVTATKPDDWDEDAPIMITDTSAVKPEDWLEEEPETIPDPEAEKPEEWDDEEDGDWIPPMVPNPKCEDVSGCGPWTAPKIRNPAYKGKWTVPKIPNPDYKGPWAPRKIANPAFFEDLHPSDFTKIGGVGIELWTMTEDILFDNLYIGHDAAQAKKFAEETYHVKKPIEKEAEGSNEEELEEPSSLVDKVQLKVYEFLHLATFDISQAVKQMPEVAAGLAAAVFTLLGMLLALFGFIGSAPTKVKQTSVKTKSVAPVAPAGEEEKKALEQAGVEVPVAEGSKKRVTRSTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT82</accession>
    <name>A0ABR3BT82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614038.1">
        <property type="nucleotide sequence ID" value="XM_066757654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990010"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="236"/>
            <end position="306"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="571" mass="65627" checksum="FFC7794FA7FDBD27" modified="2025-10-08" version="1">MSFTLDVPPNRSIREKLEWELRDLRNFMLYLDNNDNFNEDNSYQIPSYERIASMGVFELAMYAARYFLPKASSSPANEKAKQDLYLQIWCRDELENLVDLTTPARIFLGITYCNSNPGHRYAQTRYVWSETLKHNFHNDSVMHFVLPLLSMLLEDAEIRRDDALKLCVYIEVAAPEKPRFRLPNDTARKTTKGLARLLDKKSGDVRFICLEHVYNQSQPPSVSGRATEVDPEEDLSDIKVTRQSRKRILYAHSEILEEKSEYFKDLLTSGFAETERYNTIIVDDASFSTLYWILHYLYTNDLTFSEHEDYRYINDEHRLDKAYVDRILRPQTSTQNGSAEWNYLRLPLVGDWDAEVDSTSPENEPINLKDAPSSKISAPLQAEVANISETYGEKGTPQQQKKMKKDAMSTSPSKIPTMTVPQNYAFATPNSSKPHFIASHLSALSRPNSSFGIGTSARIGSGNDPHPHPTPNPPPASALDVYMLAHRYRLEELREMAMEQILRNLSYETCMSAAFVSYPYEELHSKVLAYIAKNWTQVKASSAFLRCIKEVREDVWGEYGPMVLHNIYLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU62</accession>
    <name>A0ABR3BU62_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613830.1">
        <property type="nucleotide sequence ID" value="XM_066758428.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990803"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046420835" evidence="2">
        <location>
            <begin position="23"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="615" mass="60182" checksum="8427033EBC9D710D" modified="2025-10-08" version="1">MRPNVAFVVLLCLCKAVAVSHAVREDVEDEHRLVKRQQGTGTSDAFSSQAAPSDTGQSSVLITTPVDSSSTGPATSVLLSSVTTSDVGSSTVSLTIESTSVTPSTTALSNEPSSALPSSDNPPTSSMSSTAAPTSNGPSTTSSPESSIQLSSSPTPEPSSSFSPQPSPSFSPESSIIVASSSSAPTSSGATTSPEQNSAEASASAAESPAGQSVQPSTSPSATQSASPSSVSPSTAPSSMAPQPSSSQANPTSEPSSAVPTSSNPPASSSVASLSSAGQVPSSAVASSVYVPSSSDTSSGLTTSGPASSQSAASSEAPSSAISSTPSPSQSSSQSPIQNSGTSSAVTTVSTVSTSVSASPSVSPSATTSAGVIITPSGSSPKASGYPSITSSFPAPSSIQAQSSSSSTSSRVGSQTISTGASMTPSSAAVSSNTISPSRVAAGSPITASSSRPSTTAGGPITVTATNTYTTPFTRTDAAGSVSTGNEVKTVTVIVTANDPNQPSQPTKAVSEGPGVVVVTVTATDPAATTASDGGVVVVYVTETASTTDQSGHPTNVMVTITEQVHVSIVAGVTLTAYSTADDRGSLQSHGDVFSVRHSATFVVAMNNQHNLAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU74</accession>
    <name>A0ABR3BU74_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614581.1">
        <property type="nucleotide sequence ID" value="XM_066757112.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989424"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="66" mass="7656" checksum="FB24F52115A9DB39" modified="2025-10-08" version="1">MLCYWDARQEEAHANLFHNKSLSRGKGIPPFHVVVRHGSTSAAVKEWQPSHLQRVFSDSHFQWAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUA0</accession>
    <name>A0ABR3BUA0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614440.1">
        <property type="nucleotide sequence ID" value="XM_066756971.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989283"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="297" mass="32930" checksum="E338CD2C4055AC53" modified="2025-10-08" version="1">MSPLTPESINSGFIIPPYDHRLSYASSSASNIQPINTDVDSCYSRFVRSFAGSASLFPNSRLLPNPRPIARSTLERQEPSTSQTPSFHMDKDVSAMTQPPVSIKLHSELLITGEPRGDAKEVSRSISPQYHIEQSPPPEQNSDVNRVDRQLQYLVDPRLKLYPFVLPPNLWEEPTSEGLVQSDQEIQQASRSIVPLSLSTLNVPINTCSTYSPSQSPPRPSTSVTPLIIQNPHFSDPRVGKHRISPALLNRPLNESLHLSSLISYPGEPSEMGQLVWLNAKTAYHLRKGGCIFTRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUP2</accession>
    <name>A0ABR3BUP2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ5</name>
        <name evidence="6" type="ORF">I308_102843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614847.1">
        <property type="nucleotide sequence ID" value="XM_066757378.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989699"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="323" mass="35940" checksum="14AB1C327276E931" modified="2025-10-08" version="1">MASIKSLLRPARAVSRTSSSHVRFITNSVSSRESQPTPGQTTPSSKTTHFGFREIPEDQKETLVGGVFSSVASSYDLMNDTMSLGIHRLWKDSFVSTMLPRLPPSFHRNPNDPVTEKPVFKCLDVAGGTGDIALKLLDRAKDKFACRDIEVEIVDLNEGMLNEGRKRVAKTMYYNTPQIKFTHGNAQHLPSHIADNSVDLYTIAFGIRNCTSLSAVLNEAYRVLKPGGRIGVLEFGKVTNPLFREIYRQYSFQFIPVMGKILAGDSESYQYLIESIERFPSQPEFAKLVQEAGFKTGQMREGRGGAWTDYTNGIATVWTGVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUT8</accession>
    <name>A0ABR3BUT8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613758.1">
        <property type="nucleotide sequence ID" value="XM_066758356.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990731"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="64623" checksum="EE10D436B018C8C1" modified="2025-10-08" version="1">MELLRTLHLETSQFFSSCIRPSSVACIALYTFGGIAIPLFTIYLWLWPFQYATLHFRNLPGPPSDHWFWGVIPTLIKSPPSVPHSIWTDEYGPTIRYRVALGAQRFLTIDPTALNYILSHVDIFPKPSRVRKALSDLLGNGLLTAEGYTHKKQRKALNPSFSPAAIRGMVPVFYDKAYELKAKLLSIINDDETEQASPTPCIKEDEVEGGKKIDVMKYLGKTTLDVIGIVGFNYDFKALSEPHNELSEAYSKMFQASMDPDFWDFLRAVIPLVKKLPNKRAAEIAARKAVTLRIGKKIVEDKKREVMSAHSEGLEKREDIGNDLLSILIKANMASDVKPEQKLSDEEVLDQITTFMLAGNETSSTALTWILYSLTQHPECQERLREEVLAVADDRPSLETLNSLPYMDAVIRETLRLNAPAPGTLREAKQDTVIPLSMPVKGRDGKQISSVRINKGTVVFIPILTVNTSPAIWGPDARDFNPDRHLKTSSNSFGGANMHVPGVWGNMLSFFGGARSCIGYKLALAEISTILFVLMRSFEFQELKSKPEVEKKASVVMRPRIKGEESAGLQMPLMVKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVD8</accession>
    <name>A0ABR3BVD8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615079.1">
        <property type="nucleotide sequence ID" value="XM_066756302.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988606"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="216"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="581"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0252359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="922" mass="104234" checksum="4DBBDCE325508299" modified="2025-10-08" version="1">MVPRPSSVASSSRGTTAIPVSRPPLEQLIYSLVPSLAPVRGTRTDDPKEKEKRESVAEMMEWCQGILDSNLPSSTPLSAETLPETVKRMIYASASAGAKEGGAEKALKFSAIWNKLERGKLLSSPNPHLEFLAALSPINLNNTSKPTVAGSSRSSRDIPPSTFSFTKPSSSREPLADPVSNTPPINFDPKGKTKADIINRWRTTRSQPPFPQHLLLRDTLYLLQGIDGRYVRFAISPPKEQNPYLTERGREGEGTGFPLGKEGPIIEEGDDDEVVGIEIVADEAKDGVISQPIRTLLMQLSEMGMLYRRVTNFINSRQAGDSKGGMIEQSLCHFLHHELSEYHRLLAVLESQMNTASSNGEQAEGGLTLLRLGLWTEDMKLKLKQMSTIVDEAKNTHGGALVSKLHSHTSNGDPLIRNFTTQILEEVSRPFFLTLQRWIFSGELHDPFKEFFVQLNHESVLFREDRISPTGDVGFEMGMDADGGEEEAYKLWEKKYVFVKKMVPGFVSEDFAKKIFSTGRSLNFIRYSCHDSDWIETQGKIANAGRALKYSDLAGLERSIDDAYSIASQRLLEIFFDKFRLLDHLRALKSYLMLGAGDFTELLMEAMAPRLSKPAISLYRHHLTSDLESAIRGSNAQYDSPDILRRLDARILEYSHGETGWDCFALQYKVEAPLNAVLDHRAMGDYDRLFNHLWRLKRVEVTLTQNWMRVTSGSKVYERIPGLNNDWHHCRIVQAEMVHFLRQLQAFCQLEVIECSWADLIEFTSKREGDLDALISAHRKYLNRVVRKVLLLSAKRDKEEILLDLVRDALELILRFKDAMDDLYAWSLAEATRLDRQRDASRGLYTPSTSSDDPSRSEEQLQSIRIRIRECSNSFQHRVVSIVHMAGVHADLDIRFLAIRIAFNGHYSLRKKDKGSSRSTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVJ1</accession>
    <name>A0ABR3BVJ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103143</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614028.1">
        <property type="nucleotide sequence ID" value="XM_066757644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989999"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="716"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="790"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="831"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="883"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="913"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="953"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="978"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="1179"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="568"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="576"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0249841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1238" mass="132505" checksum="634EF2B204C72455" modified="2025-10-08" version="1">MPEQRVPPSSEPISTLMSNAPSSSTTSIASTVRPVRPASIVSLRHPQPQQHRTQPSASRTGSISQSRRQSVDTSVPESQSTSPITYFPNPSSFANSQDTNDNSISSTADSTATSPTVSLSHMTSTDSDDPSAPHVISTSSIARTPRLNPVASSNVIGLDTGAPAPRVQTSRAPGGHAQTSSGTTSSTSGSVSSTIDQQSRRRCSSRVFSTPGAGYSATHPNVGLGLGPTPSRAGTGSTSTTVNDAALSSPRRISTSRGLHVPPQTAAPPAGNLGLPTHEAYYSVSQPVSATTPRFRDKGIYVSGGSGGLQHHSSSIGGYPSGSYGATHQNQPSRDLAPTSAMGATVHSPFPSPKGSVLKKLQKKASNVGLGLGRPDNYDDEALGRYGDEDEMLEDNLGERANGTRVWYSSFATIDWIHDAIKESSRVRRLRHAASRSLRGRIANTWDRFQGWLVVTLIGIITALIAFLIIRAEMAFFDLKEGFCSTSWGTAKRFCCAPRHQSPGSDGGEYECSDWVEWGQLFKPKAKDGPFGGWVYGGPEFMAYATVALLLAVIASCMTVYLSSSDHHTTSKDSTFLTPPSKVTTAKQSTASSPTKRTTSLPYGPHDERQPLLDAITNEPPTPLIESPPEPSRKVMFYAAGSGIPEIKTILSGFVIHGYLGGWTLITKSAGLALSVGSGLSLGKEGPLVHISSCVGNIVSRMFLKFECNEAKRREILSAACAAGVAVAFGAPVGGVLFSLEEVSYYFPPKVMWRSFWCAAIAAITLKALNPFGNGSLVLFAVSYTKEYQYWEYIIFIVLGIFGGLYGAVFARLNIIWSKHVRNGTWLKRHPIFEVALVVLLTTVVSFSNPYTRMAGTELVASLFEECNSSSSSKLCVSQPHELATVIWEVFMALVIKGCLTIITFGIKVPAGIFIPSLAVGACFGRIVGHIMEYIEFVHPDLSIFSVCKNTDCVVPGIYAMVGAAATLAGVTRTTVSLAVIMFELTSTLNYVVPVMLGVLIAKTVADGLERKGIYDLVIDLNQLPYLDSKHEYLWGSRRASSVADRSVPHLRADKPHTVRSLTGKLLELVRLGMEDTGFPVLAKEVTSAGGPGTNVGLGLEGGIGSGRERSCLRVVGFLGINELEHALSELADEPDAAINLTPDDATQARIRNSALSIFSFADSFVDNGWNPCDLSRYIDQAPITVQIHSPLELVQQLFVKLGVRQIIVVNSRGVFQGIITKKAWLSFLNELEEGAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVK3</accession>
    <name>A0ABR3BVK3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101798</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615127.1">
        <property type="nucleotide sequence ID" value="XM_066756350.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988656"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="100"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="556" mass="61374" checksum="2DFF859D058314A8" modified="2025-10-08" version="1">MEKLERIHNIHLERGQFSVDYQYDTESSPIISCDKSLPSLHNKLPTPSTGATEAPTPAPPPEIELSPTSLSTREARQVIASFPTSPANPINWTTRKKWTITAILALTGFISTVGSSIGVPGLHAVMSEFEETNEKIGVLIAGAYVLGLGTGPFVFAPVSELYGRQVAYVSSQIFYVLFTLGTGFTQSMAALIVLRFFCGCFASPPPSLGVATCADMFLPHERGKPISLYALGPISGPIIGNMVGYWLLFGGWRWAYYFMTIVAFLNFILMVLFLRETYAPAIQKIMTYRVTHPLSLATSSRRHCLPDMTWMTAMVSKEDAKTVYVRAFSRPPRLLFTNPVAFAFSLYYAYVYGIIYLFLVALPLLYGKPPFSQPILFSYKWPLATMGLPYISMGLGFISAVVIASQCQDRIYKHLSKLNGDKGQPEYRLVLTQIGMCIMPIGLFIFGWTAQAEVHWMGPFMGQAVMGIGLMLAFNTIQNFFVDAFYPYSAAAVAGATAARSVVACIMPLFTTTMFVKLGWGWGGTLIACIAIVGIPAPMIMFFFGQRLREHYAFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW74</accession>
    <name>A0ABR3BW74_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615346.1">
        <property type="nucleotide sequence ID" value="XM_066756569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988876"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0252626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7977" checksum="C15DCD072536F7F0" modified="2025-10-08" version="1">MSSELRYTANTQLEQLHARYTGTGHADTTKYEWLTHQHRDTLASIARERFEVTEKMLQPCGKPPGKTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWB8</accession>
    <name>A0ABR3BWB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_100123</name>
        <name evidence="11" type="ORF">I308_101828</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616602.1">
        <property type="nucleotide sequence ID" value="XM_066754701.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986981"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="10">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0255325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="103" mass="11409" checksum="AC5C20A04BCA7598" modified="2025-10-08" version="1">MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKIFLENVIRDSVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWI9</accession>
    <name>A0ABR3BWI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102138</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615466.1">
        <property type="nucleotide sequence ID" value="XM_066756689.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988996"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17474" checksum="D49779EB57DA1BC4" modified="2025-10-08" version="1">MPYQPNHVFKGVVTKVGAMRKTATVTVERIFEHPKILKEIKRHKKFLVHDEEELARLGDKVSIIHGTRTSRHKSFRLQSILSRNTQKFPDDPIPAEIPLPSIKPSKQKKLLEKAALRSSRQVDASGGSGKVIDALKEAQLAKEQAAKAAEVAGRNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWU0</accession>
    <name>A0ABR3BWU0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615557.1">
        <property type="nucleotide sequence ID" value="XM_066756780.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989087"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="294" mass="32471" checksum="C420062801ABEB3F" modified="2025-10-08" version="1">MSQPFKTDSLRPSSLPSATLGRRRPQLPTAAAIEGEENLTPGERAQRVLEKEHERWNERIDRDVKACVEGLKELVQLADISSVQPNSLTSTTLPLHLPVRTSSLIRSALNIRDMAHELKLLLLLSDEVGIVQARDRERRIVREEVERGREGVLREIYKTLGRQLESDSEETAMDKATGADSAGKDEEDQGAKEDGEDVMDVVSEGKPQPLSPASPPEGVPQLTRGISVEKQDVKNEEVMDVDDNEDEDDEDSDVVEVINDSNLASSAPAPPPAPEASTEIKDDSEEDDDFEEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWV9</accession>
    <name>A0ABR3BWV9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Compass component swd1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615324.1">
        <property type="nucleotide sequence ID" value="XM_066756547.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988854"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55164" checksum="9EE76426E7236812" modified="2025-10-08" version="1">MQQLLNPFAQKYPDAVDSTLFTQGVCLSFNRSGPFAGHYLAVGNSHGTVEIWDVETRGVVRVLEGHVKAVEGLSWSRNNRYLLSASSDGTAIVWDLSVLPHPLLSPRTPLTSELHAGPSSSRLHTIRFDSPVISASFHPRNSRIILVVLSCGEAVIVDMRKGGGKYRLEDVLDEDETAVNRKRISMTCADFSPCGSRVYVGTSNGMLVVIDPMTRQILQRAKLANSGIRQLSFDTSGFHLLTSATDRALRLLHIDPLTLSLSPLHRFQDLINRTPWNSIGFSGDAEYVMGGAAHKMAHNVFIWDRESGVLVKVLEGPKEPLIACTWHPTKPIIASITTSGDVHVWQTSSPDNWAAFAPGFEELEENVEYDEREDEFDIEDETELNRRKDLEEDITVDLLTPQEDAFPRRARPILSLPSNIIFANDDEQLEAMRLVGSISTVANWADKDTAVYGDAAVNGDAEKEESGEAADGAADGDDWEGFYLSQDLLSDIRNDEEAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX26</accession>
    <name>A0ABR3BX26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615655.1">
        <property type="nucleotide sequence ID" value="XM_066756878.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989186"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="118"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="5">
        <location>
            <begin position="636"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="556"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="82083" checksum="0E26449C84B8817C" modified="2025-10-08" version="1">MYNGQPPFPGNGLPPFPPQMPPNGAMPASFPPFAPPFPPPFPGMRPPSGPGVPSPATPGMMPSPVPMSGMQTPGMPFRPPPMGYTPRPAHPGLGLTPHGLPQPPHMPTSTPKPDVKTTKVFVGGIAPGITDETLESLLNACGPLHELKRVIGASGKPQAFGFAMFENPEVVLRCIRCLNGVELPDMTPEGRRERKPAKRLIVKADEKTQAFLEEFESTLGRSDSDEEADASTRKSVQHIIALLTDPNAQHPDGPSASNNGGQSPVQVVVPAHLQDLQEGDLPEEQRVAVLGQIAVFRENAAKREREKKLMEEEKERYKAMQGQGGGQRQAPSGYGYGNRGLAKQQQQAERQWGSQSASPAPAKGAGPSRYGPGERDPQAYDKPVSFIKAETTEGKAESGRTDEEEEELRRRKIQMDKDIALRDAERRVEARERTRLDALSREMNYRQTQKDLIARSRARQEDLYARYDDDDYIERDVRELFYVDRPQWRARRQKFRQNEYQADLRDRQHEEDERQALERESEEFLKKQMAELAALEQSQRAQGLLTEDAAPIKLAINPSTLPPLPPKEEKKHVVAPRPGVQFEGEDDDEESGRKKKGTFVRLDEEEEGDGLSEAEKRARRNARLLEVKKGVPNDRRSIWKFPVEWAAVGETLVQSKIKPFVQEKIKNFLGELDEDLADFVLEHLRDRKGADDLVDGLEPILAEDAESFVLQLWRQLVFESLAFKEGIDTGSMMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX83</accession>
    <name>A0ABR3BX83_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_102300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615627.1">
        <property type="nucleotide sequence ID" value="XM_066756850.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989158"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12568">
        <property type="entry name" value="RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034482">
        <property type="entry name" value="Mrd1_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
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    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="205"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="401"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="519"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="624"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="478"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="723"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="739"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0252907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="753" mass="82800" checksum="A18BA61F25A502B8" modified="2025-10-08" version="1">MYVGTRSRLIFLNLPSTLNLESFRKTLLSPPTFKSTTITDTKLVPKRRFAFVGYKDAEEAQKVKEWFDGTYAFGGGKVKVDFVKDEPLKNGNKLNRGEKNKEKRPKEGKDNIQERQEPSKRLQEFMSVMKGVDPAMAPSEASTSTAEGTKKKEKSVKGKEKSEEPEEPEADDDDATWLRRRQAALEGEPSAPQLSADEQLILSTSRLFVRNLAFITTSESLSTHFSTYGRIDECHLPVSQTTGEPLGTAFLQFHNAEDALSAYKALDKTTFQGRLLHVLPGRAKPGQGGAVGGSGAVDSKVLGKRDQGKGEVKSKVDERRKQESAKGVNWASLYMNSDAVAASVADRMGISKSELLNADSGNSAVKLALAETTVIEETKKYFEDAGIVLESLQPRVPRSQTTILVKNIPYGTSIQNLTDLFAPHGKLTRVLLPPAGTLGVVEFENHMDAGRAFKALAYRRLGNAVLYLEKGPVGMFKSETAHGSGPMSTEQKREEEAKALAEKVESLPEQPDPTDEAGSTLFLKGLNFATTTPHLQTVLSNIPGFSFARVQMKPDPKRPGEKLSMGYGFVGFKTKEAATKALKALEGFEIDGKNLEVRFAQRGAEDDRETKKVGDTEGGKTKSTKVLVKNLPFEATKKDVRELFSAYGQLKSLRLPRKAVPTSTGAQSTRGFAFLEFTTHTEAARAMEALKHTHLLGRHLVLQWANEGEEVDVKGLREKVKGEVRGMEGGGDRKRRKLDFKGDKEHEMDGLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX89</accession>
    <name>A0ABR3BX89_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615456.1">
        <property type="nucleotide sequence ID" value="XM_066756679.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988986"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
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        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="78" mass="8486" checksum="6F02075B9D5535D4" modified="2025-10-08" version="1">MIVKVKTLTGKEVDIDVQPDMTISKVKERVEEKAGIPPVQQRLIFGGKAMGDDKTIQDYKIQAGAAIHLVLALRGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXN3</accession>
    <name>A0ABR3BXN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102789</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614793.1">
        <property type="nucleotide sequence ID" value="XM_066757324.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989645"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="164"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="773"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="877"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="775"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="807"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="891"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1058" mass="118627" checksum="610CD1C22AA1C922" modified="2025-10-08" version="1">MSHHRSSPDQPPYYPPPHPSYQPQYTDSAPTRPPRPMAISLPQFQPIPYPQQQSQPSLTSPYETPLMPMSSTPLSSHHEGMVDYFSIWNGQNMQPVSDFHQHSFQHHAPPSQHSSSLSLPNQSPNEWQSQAPRSSRKTGRQPNSRATGSDSTSGTKTARQQFTACGACRHRRVKCDLKDKQEQVEKTTLSESGGRTGPMREQAKKIQCSNCLERGLNCVDEFAPIKAAKQLRRGKRITEIEQLYGKSASNSASVHDSASTSSVDQRLSSAKSDSQRVQPIIPKLTPEFFESDFFRRFQVQRPLIDPGNFLERYLSKTNPHETAMDIENAILCHVLYAWAVSYGVDEYGRLDLPEGGREPLTGVNVTSACPGEVQREKDRSVRMEKMKCVIQVILKEIDDCGVMRKPTWDGVRVLLMILPLTEGISTPVERLAMYDAAISQVFMLCSHAAMGYDGQPSATTAVNGGTEDDQGITAAVRVRVYWYAFVHEGITTGLKGGRLRLDDEDLETMQDIIDNNALVRDSVSFRISTKFATAPINLALACRKINKALTGPKAKRRITVNVDLVKQAWEALESCWEEFNDLLKVGPDQKYILGEEVARFADGWKIFLFEAQNVIYNNLEARRQKLSDTAAQVTARITESVSPSSANSPEAMHADLISIGHLLDIAKSKCEVKTRQIVDLVKMYVGTRFFEWDASLVRDGTYYAAMWLVKQGGSSEDVAVCIQALNELRWAHAKAWERSAILRKGWLEKHVADDSNEQNQKWDSVITNLEKLGEDNTTLEIPQSQRGVPEQPTMPPVNPGNPGIHINESQSHLQDDSNQLKQTHASLDNSIHQQAQHAHSSPIYPYADSQDHLHQSLHNSYPDQPRVDITHPVPITPYSSQPSGIPGPQHQAESSHISTADSTFTSSHTTPPINDTKVNVMDMSSNYHHVHTREGFFEEMRNDPAQSHHGLVGHGHGDIMLGGHGYRTYEKFDGQTGYTSIEGYSQSRQVHQAYQFHHDPSHLHPHVLPANRDGHTLETGHGDYSYQHHTEELQERKELQGQYVLQYDGTHVFTPYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BY95</accession>
    <name>A0ABR3BY95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615221.1">
        <property type="nucleotide sequence ID" value="XM_066756444.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988751"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="5">
        <location>
            <begin position="91"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="567"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="638"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1091"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="645"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1091"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1157" mass="130266" checksum="2D54811E13E1D8AC" modified="2025-10-08" version="1">MEAPHKAHHKPSAGAKHAKKDAAKGVDRSGGKNFNPKAFTNTSFRAADRAARRTAEKNQQRLHVPLVNRNPEERKVTNEKGKGMDEGALPPPPIVVGIVGPPGVGKTTLLRSLVRRFTKHNLSQPQGPVTVVSGKTRRITFIECGNDLNSMIDLGKVVDLVLLMIDGSFGFEMETFEFLNILQSHGFPKVMGVLTHVDLIKKASTLKDTKKRLKHRFWTEIYQGAKLFSLSGVMNGRYPDAEINLLSRFISVMKFRPLVFRNQHPYLVADRIQDLTPREAIRENAKIDRTITLYGYVRGPNLPPRNAKIHIPGAGDLEVKAVERLADPCPLPTLESERRRKMGEKAKLIHAPMSDVGGVMYDKDAVYINVPGNFTKGGDTPRGEGEKMVMDLQDAEKTFADNIQASEIRLFGHSSAPLQVTEERKDRVRRRAESRSGGPMLGKADDDEFDESLDEDDEFDDASDAEDGGGFDEASGESDDDDERDVAYAESESDHDDLAFATGFEQEGARVNFDDDDDEEDFPSDEDDEDVPGWKRNLASRASSALADRLGKKHNLMALIYDSALSPEEIVKGKTRPSSADASSSVPELENEGLFRISREENKGDDGDQVKEDVDRDQLKSKWTDEQMLDSLRGLFISGPVAGEGVDENGEAYEEEGEDFEDLEGGSDGQGEGEDDVPYVGVKPSQISVEDARAAALAKKKEALKIKFDEEYDDSDDEASKMDFYDQQKAEMARQKQINEEEFGNLDLDARAQIEGYRSGMYVRLEIEGVPCELIENFDPRFPIIVGGLLAAEERFGFITVRIKRHRWFTKTLKTNDPLIFSLGWRRFQTLPLYHLDDHSIRNRYLKYTPEHMHCFATFYGPVSAPNTGFCAFNSLQGDAPGFRVSATGVVLDVDRSTKIVKKLKLTGVPYKVFKNTAFIKDMFNTGLEVARFEGANIKTVSGIRGQVKKALSKPDGAFRATFEDKILLSDIVFLRAWYSIEPKKLYNPVCSLLLSNKESWQGMRLTGQIRREEGLKTPLDPNSAYRPIQRTTRRFNPLKVPRKLAASLPFASKTPELSKQRKPTYMQSRAVVMGEDEKKAVTLLQQIQTLKKDKAERRKAKQDERKEAYRKKVGEKDEKREEKIREERRERFKKEGLKRKREEMSEGKGRGKRNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZX8</accession>
    <name>A0ABR3BZX8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616158.1">
        <property type="nucleotide sequence ID" value="XM_066755872.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988173"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="58"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="518"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="683"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0253937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="765" mass="83176" checksum="3456C1BB22AAAF19" modified="2025-10-08" version="1">MPGSPPLQRHVSTKDELLQKALTLPLELRRELATSLLWSMPRNEVLALNESLNMMLQKDIVGLLPPELAFLILARLDFNDILRCSSVSRTWRNLCNKQALWALLCATKSPPIRPLPISWAELTAQYSLPTPMDDIEDPTFDISLSDDRLSNHYDVISGQGGMGGGGGIDPLGMSGGLRRSVWERGGAGSGEGLPVHLKRSAVDVQELKKKDEPPIASHLSLPSTNPHANFKHLYIVHHILEQRMKTPRPIGMANYMPSPPEEAKANMPPLPPIPRPRTIDAISSVKYGGLPGHSEAVYSLSLISHSMRINMLQACPDCQVQLGIPSNLSSTTEGQFQLSVIETLSGTGTSRRSTLSNSSQVEGRKDLVTGRDWLLSGSRDKTLRLWQLSPAPRVVKIFHGGHTGSVLTHAIVKVPCLPFVSSPQSRFTKREIGSSAKEDRIRVKVMAVSGGSDGRICLWDVEGGNGEPEKCVKAHDDSVLCVRADDERIVSCSKDKTIRLFSIHTLEPLLVIGATGDSYLHRGAVNAVGLSKDYIISASGDKTLRVWSIKTGALLACIEGHHRGIASIDFSPLPLSCVDLPDGQISKGLIVTGSSDASIRTFHLVEDRIPNMQNFEMDHSLVTSPVDGSEDGHFPANACGIPTELTEEEHRVILVPQGSFFSPCICPPGLSRMEGGTCKRCFNRGHLDLVRTVHFGKGVVLSGSYDATVKVWSPTGEIIADLHGAHTGRVFSVVGDRMRVVSSGLDCRINIWDFSEGLDTSFVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C011</accession>
    <name>A0ABR3C011_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616199.1">
        <property type="nucleotide sequence ID" value="XM_066755913.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988215"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="627" mass="68518" checksum="D34E5E64583EC9DB" modified="2025-10-08" version="1">MPTRATRSTQEASPTSPLASAAEPTMNKRKRPSHDPPKRPFPDQKRPRVISKPTGTNEEHGEADPSSPLGMSPPPRSSEPNVLSPEVRNALMDIISQGREKYTAIYPSPAIADVGGDTIHVFSENLLFPVRYPNPLPPRASFNIPPPPLPSHYPPHKIYNFCAALYGLLLDIQPAKDQFSNFGTERWALVQKTSQGGGEWFTGSVDHNEAAKVAVSGEQGDNTLETMTTQSRLGESMFIRYSLTDDRQCDPNNTELYFVWKELRRRKAGGGFGSIARGGESSTATDFRLPIVAIPNVGSSSFTPTFGPAYDSSGTTAGQGYYFTVEAMHERARHREWTQRALAMDQKLEEEDTGECIEESIQDRAPHHTVDGALVENGRLIAELQTWQEIRLRKGIESATQREQILARELLSSLSQLTQVVTPAHLLPALRTKPGWSHILGRHILSTSSPSIRGTLDPRRPHALHDNTTIQLRSTLARNGVSNISNGSLPHNTPALVKTSTMPPPPSPQFSAPPPHILPISSPHNMSPVVTYNVSGRTHSPYLNPATPQPQPHSYSSFSPVPTAMPASSLVHIRPVQTMPATGAYLRSGPGPSNLRQSLHQTPMGSQGPGVYGSPAGPGNNEYMWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C030</accession>
    <name>A0ABR3C030_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_101370</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616212.1">
        <property type="nucleotide sequence ID" value="XM_066755926.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988228"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="13">
        <location>
            <begin position="71"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0253991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="334" mass="37175" checksum="1E680B069F8B9B0C" modified="2025-10-08" version="1">MASPSLASALTLSTVGLASRSFLRLTTKEFKVEGLPTLLDALSIPHGDKSKGKMSNVGDGSDPSLKPRRGILTICNHNSVVDDPMMWSLLPLSTYFPFASPSHTCRNNRWTLGASDIMFTNSVFSKFFNLGQVIETHRGAGIFQEAIDRAVKLLQEGNWIHIFPEGKVNQQLTNPEGGLLRFKWGVGRIIMDSEIMPEIIPIWISGFDQIMPETRGFPRFIPRPGAHVSITVGQPLTSQIQPLVKAWKDMASKEKGTLGIGGEWEQKVKGEGLVGQKQREVRGKGQLIDGREKEVRIKIVEALQEGMRKLGQDVERREGRFKKGFWSQSTRQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C099</accession>
    <name>A0ABR3C099_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615796.1">
        <property type="nucleotide sequence ID" value="XM_066755510.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987806"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="16340" checksum="0463E8482FFDCDFD" modified="2025-10-08" version="1">MTPVKMVKIYKPGKVAVVLSGRQAGKKVVVIKQQDDGTKERPYPHAVVAGIERYPLKVTKNMGKKRIARRSKVKPFIKVVNYAHLLPTRYMLELESLKGSVSSETFKEPTQREESKKAIKKAFEERYQKGQNRWFFSKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0D1</accession>
    <name>A0ABR3C0D1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101476</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616318.1">
        <property type="nucleotide sequence ID" value="XM_066756032.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988334"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="619"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="631"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0254097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="697" mass="77773" checksum="6B98F907301E07E5" modified="2025-10-08" version="1">MADAKLFTRTKIQELKDELRGSNDKRDKGFVRKKTALKKIVANMTMGNDVSPLFPDMIQCMAIQVLEIKKMVYLYLVNYGRVRPEELKGAIPSFLTDCADRNPLIRGLAIRTMSSIPLPIMVQALVDPLRHALQDQDPYVRKTAAIAIAKLYASEAGRRVIEREGFVGMLRDLLADHNPTVVANCVAALVEISDRGDDIVLKLNVNVAGKLIAALGECSEWGQIYILDSLLSFVPQSHMEAEQLAERISVRLQHANSAVVLTTIKVILYLMNYMEDEGLIRALEKKMGPPLVTLLSSGSEVQYVGLRNILLIIQRRPAILQNEVKVFFCKYNDPIYVKLAKLEIMYRLAREGNVSEVLAELREYASEVDVDFVRKAVRSIGRLAIKIAPAADQCINALLGLIHTKISYVVQEAIVVIKDIFRRYPNQYESIIGTLCENLDVLDEPEAKAAMIWIVGQYADRINNSEELLEDFAFTFKEEPAEVQLALLTAVVKLFIRRPTVAQELLPKVLKLATEDAENPDLRDRGFMYWRLLTADPAAARDIVLAEKPAISTETDRMDKGMLDQLLLHTGTLGSIYHKNPHTFIRTAKPKYLPDSPALNASSKRHLITAYGPPSLSRTVVPSLPARPTSYMPQTSHAPALTNTVPGANPMQQPTQHRAENDDPYSQLGDLEFGHGGAGGYQTDIPRPRGAEEDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C145</accession>
    <name>A0ABR3C145_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4-nitrophenylphosphatase</fullName>
            <shortName evidence="2">PNPPase</shortName>
            <ecNumber evidence="2">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616340.1">
        <property type="nucleotide sequence ID" value="XM_066756054.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988356"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0254119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="308" mass="33689" checksum="A1EFBB426982C595" modified="2025-10-08" version="1">MTIDIEKTAPPFLKTLEEFRQLVDSADTFLFDCDGVLFLGTQLTENAKVLLDMLRSSGKKVIFVTNNSTKSRRQLKAHFDSLGLDASLEECFGSAYASAVYLSEVLKFPKDKKVYVFGHEGIEEELDEVGIAHIGGSDPEDREFTPPIDYSQYSPDPSVGAVLCGADNWINWKKITKAVIYLHNPECRLVLTNPDATFPIGGSLFPAAGSMSAPIVYAAKQTPIVIGKPSKTMMDAVIAHHHINPARTIMIGDNLHTDIEFGINSGIRTLLVMGGVTKYEHIYGENPSPVVPTYVINRAGDLAALAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C257</accession>
    <name>A0ABR3C257_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616426.1">
        <property type="nucleotide sequence ID" value="XM_066756140.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988443"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="529"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="353"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="875"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="892"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0254205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="939" mass="100021" checksum="011AE5901816D2EB" modified="2025-10-08" version="1">MSSLASPPPTASIPTSDSYYSAVQSPGPGPSSGSNTSSKWKSVFKLNRTATIGRGKENRSALGGESFGLENKEQQPSPGEVSLSVVTEPYLPPHGKQLRAHTDPYPPRSFSVKKNSNSASVGYVDSKVLHEEDMSKTREDGSSESFNVHLNSSNGNLQTSSTSGEQSRPYSSVTDSASASASASTTERTSHSSGGHFLPTDGSLHGSVASTRSPSGGPLGIGNFKSRFFSAPLSAPAGKAKHDKSKSEKYRGLGKVATDFTPSTAPPSSAGGASSIGGGRKKSDGSSSFSSRGAASPRTPARSKREPSANSSKRLPFGQTNDNGTNSGSVAARFIRRVVSAPNTKALFSNGLFSNAPDVPPLPTPKSQPTGSISSKEKPSSPVMVIGSSEGQIDLTSSPDSDHLPSFSPFSNSSTLYTSQTSQTTPASASATPTPSPLRQNNLFLNRTASPSPSQGSGLSAKGTRANRSLTTGTAPVLKNIRELQGNLGSSPGGGGHLDGEGRHKQVFRRTYSSNSIKTKQVEVTASSFQKIKLLGKGDVGKVYLVREKKTDKLFAMKVLSKKEMIKRNKIKRALAEQEILATANHPFIVTLFHSFQSQDYLFFVLDYCMGGEFFRALQTRPGKCLSEEHAKFYAAEVTAALEYLHLNGYIYRDLKPENILLHQSGHIMLSDFDLSKQSGEAGGAPAAIRHGGPNGQTILVDTRSCIADFRTNSFVGTEEYIAPEVIKGHSHSSAVDWWTLGILVYEMIFATTPFKGPNRNATFANVMKNEVLFPETVPVSSNCKSCIRKLLIKDENKRLGSASGASEVKQHKWFASVNWGLLRNMTPPIIPEESNGIDTINFRPLRESKSIDFDRDDLTTDIIHAKAGSPSIYGNATPGMLTPNELVQPTSSSSPSAAGGVSGQSSSAMPIPGSVRGYEKEKNPFGEFSSVTRDFGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C2D3</accession>
    <name>A0ABR3C2D3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S acidic ribosomal protein P1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615925.1">
        <property type="nucleotide sequence ID" value="XM_066755639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987938"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0253704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="109" mass="10830" checksum="7A354750255E0403" modified="2025-10-08" version="1">MSSELAATYAALILADEGIEITGDKIVTLTQAAKVEVEPIWATLLAKALDGKDIKDLLTNVGGGGAPAAGAAPAAGAAAGGAAEAAPAEEKKEEAKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C485</accession>
    <name>A0ABR3C485_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_100251</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616724.1">
        <property type="nucleotide sequence ID" value="XM_066754823.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987109"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF2">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="5"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="129"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="225"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0255447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35635" checksum="7E51BE0FEB8B2E08" modified="2025-10-08" version="1">MQTKLPPLLQATSGALGSAVGNCIVFPLDVATTRMQHASKKPKTRRLPLILTLHRLLSRRHALTRIYSGLKADTLSTVLSSFIYFYVYTALQKGLHQYRLKQAVYQAAPSPAGVGGLSSKASDTVNTKRTPLEELIIGVLAGITSKGIALPISTVSVRHQVSESGEDEKQSVLQTLLTIRKEDGIKGLFSGFGPTIPLTLLPSLTLYIHSFLLNILVPKRHRAHPPGAVTFLLGALSNALATVSLYPLILVKVLDQSGKEKGNDKRNEEESMFSTMKKLIRRDGIQGLYVGLEGQLIKGLVSQGVMMLVKQRVEERVIRFYRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4C7</accession>
    <name>A0ABR3C4C7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 3">Prevacuolar compartment membrane</location>
            <topology evidence="1 3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MON1/SAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616760.1">
        <property type="nucleotide sequence ID" value="XM_066754859.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987145"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="5">
        <location>
            <begin position="185"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="6">
        <location>
            <begin position="346"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="7">
        <location>
            <begin position="472"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="587" mass="65221" checksum="386135BF873FBCBF" modified="2025-10-08" version="1">MVSAEALISHNSPTKQFAPLHHSSQPSALSYNTLLNAPADSPALRARASTASSSRAPSVLDDAHVEYNVTESQVPEITPSMDSYEFDEGSDHTSLPSGAPSIKSKERQRSGDRNEIETVGAGGEMALPSGDARRGLKELVRKTGSVEKDYGGHDHFRLSTKLSRNENLQVLTTQSDKVSYSPRSYYVLTNAGKPVFCSHSSPSEDDVTNLMGVAQALISIFADDSDRLRYIIKGNHRIAFLLKAPLYLFCISDWGEPEHALRLQLEYIHLQILSVVSSTQLLRLFQRRSNADLSTLLEGTEPFLRNLIDCSQYDFSFLTSTLQPLRMAPALRDTSAAALMPPSKFKDLLYVLLIAGGHIVTVLRPRKHSIHPSDLHLLLNTIASSPALRATETWLPICFPKFNPSGFVHAYISYVLEDVGLVFVSADREAFEDLRIWKDMVLEKLEQDKTLSRIQEAIPLHPYTISSVGCPGLRHFIYRSRQHVQITQPIWEAPYEDGSTNQKRLVTTYQKLHDAVHAKSGQASALKVIYISTEHEACLVWATKPFELYITVSPQLSKSAVVAAANNVAKWVLAEEGRIFLKDAPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5P2</accession>
    <name>A0ABR3C5P2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pcc1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617217.1">
        <property type="nucleotide sequence ID" value="XM_066755316.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987609"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14849" checksum="6C3EABED587FDD1B" modified="2025-10-08" version="1">MSQLGELEDQWHTVTLKIPFHTSEHALIARRALDVDREQNGSLVRREMNVEGDVLIVNYATTSVRLLRLSTNSFLSSADLVLRTMSSFAPDPSDRIPTDEELEELRQEANRNTGAGGGIELKGDGKGAGSGEEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5Q4</accession>
    <name>A0ABR3C5Q4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Pyruvate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_100758</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617224.1">
        <property type="nucleotide sequence ID" value="XM_066755323.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987616"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="11"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="249"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="457"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0255947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="67716" checksum="9241D37D99A6E501" modified="2025-10-08" version="1">MSDSEQVAFFAYILERLKQCGVKQIFGVPGDFNLTALDYIEKDPDLQWVGNANELNAAYASDGYARVKGTLAVVVTTFGVGELSALCGIAGCLAERVPVLHIVGAPSTYMQAKQSLLHHTLNLPESFSTFSSMSAPLSCSQALINNIEPKTPTSWTEAFDKTLKAVLEQCRPGYVEVPTDAVHARVSAEGLKQPLPPPHSAPPPESVATSLSNTGASAASQGAAQVSLSTAPTNVPSAPSSDDVTAHVVEDIAKRFGEAKKPIILVDACAGRFGMALEVRNLVDACGIRFFETPMGKSLMDEHHPLYGGCYAGANSLPTVQKEVESADFVLYVGALKSDFNSGSFSVNIDPKVIIELHSFTTTIGYASYPTTDIRTILPLLRPAFEKLGRGKHSKGQSVQQKVEDKSVDSPVVPDPKGNEIKHEWLWPRIGQWFQDTDIILTETGTSSFGLTNVVLPSNSTYIAQILWGAIGWSVGACLGAAMAAKENGNNRRTVLFVGDGSLQLTLQEIGTMLRRDVHPYIFVLNNDGYEIERQIHGWNAEYNDIQPYDHQLLLPFLAGKKTKTPYQSFAIHTPQELSKLLDDEEFNKPDRLRLIEVFMPRGDAPAGLIRQAKLTAEANDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C646</accession>
    <name>A0ABR3C646_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617088.1">
        <property type="nucleotide sequence ID" value="XM_066755187.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987478"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF21">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="131" mass="14888" checksum="4A9952A265F3F067" modified="2025-10-08" version="1">MTDQFGHMERIVQTPLPYVFRVHLEPVVSLYFFIMPFTLVDAMGRKMVFIMFCINITFMSVEDVAAMIEKPFRTSDPSDLNLDLYCTELLCEYDAFIECLSEGHEGNMPVHGRSKVDQAAVDYGADDGEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6D9</accession>
    <name>A0ABR3C6D9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617178.1">
        <property type="nucleotide sequence ID" value="XM_066755277.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987570"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="300" mass="31928" checksum="22DAD4D2FE77B85F" modified="2025-10-08" version="1">MAPHQPDIFLFTRQMYGSIPSCVVECMSDGNITGCSSSTDYSCLCASAYYINSVGTCMDSSCTASERTAGEAYTEEACAYYGTPLTNNTSSSTNTSATASGTAEIADPVIYSRAYINIQAIFSSICGALLILALVSGFLSCRSRYKREQAFSQNRTWTGVGSTALGGDTKKTSRFFTRTKDTRDPTATFATDNYGVNSSTFGGTTTLHAPGQVSFGPIYGTTGGYAAGSSGTGGRFTNRLPAGDMDDSEEWEMEVRKSNIKEEELEVESPTTSKGPGSDVDVDGSTVHLTRLDKDDHHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C711</accession>
    <name>A0ABR3C711_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616571.1">
        <property type="nucleotide sequence ID" value="XM_066754670.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986949"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25772" checksum="B7D302FDAAFDA97A" modified="2025-10-08" version="1">MSENPIKTLQDLTFHPYSSAPAATTLQHDHLTIQAPKLVDWWRNPEPVKVNRKDGPFAHIAIDGSRPFQAEVWLRSGLKGLYDQACLVLHGGELADSSAHWLKTGTETFDERQWINAVVAAPWCDVSAVLSDIELSSEADGDWIYLKLVKELSITGHTILIKWARQSVVDANNPPTDKELANLREVQAFGVKESGERSSDYNWSIGVMASGLMNDEGAFAEFKGFKFKYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI22</accession>
    <name>A0ABR3BI22_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610853.1">
        <property type="nucleotide sequence ID" value="XM_066761028.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993460"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="95"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="255" mass="27415" checksum="77831D968B799D72" modified="2025-10-08" version="1">MGRVIRAQRKSGGIFKSHTHHNKNPARLRNLDFAEKNGYIRGVVKDIIHDAGRGAPLATVVFRDPYRYKLRKETFLAAEGLSTGSFVYCGKKATLNVGNVLPIGQCPEGTIICNVEEKIGDRGALARTSGNYATIIGHNETGVTRIRLPSGAKKTVSSRCRATVGIIAGGGRIDKPFLKAGRKHHAMRAKRNSWPRTRGVAMNPVDHPHGGGNHQHIGHASTMARDAPAGQKAGLIAARRTGLLRGTQGKNVDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI75</accession>
    <name>A0ABR3BI75_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610892.1">
        <property type="nucleotide sequence ID" value="XM_066761067.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993499"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044958252" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="110"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0240393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="649" mass="69924" checksum="354E5E9A80717EB6" modified="2025-10-08" version="1">MRCLNILPLFLSFVADASPLQRRQATSSTVSVPWATLVPASTIASSASAAISPAIEPGASNFASSSIVESSNSSTSASNRTIPSPSSNVMQAAPAVTIYPATSSGQPIEITGTRMTDARQDVYLGIPFASPPIGDLRFAPPVSYTYNPSTFQATTAPPACMQTNLLVHKISEDCLYLNVYAPAGSNATTDRLPVMVWVYGGSFTSGSSNLYPGTGLVAYAERIGSPIIYVALNYRLGAFGWGTGSGFAENNAANLGLKDIMKGLSWVQENIWAFGGNPDQVTVFGESAGAISISLLFLNQSTTLFSAAIMESGAQSTAPIGPTNSTWEDAYIALLAATNCTSPSAGNVTQFQCLKALPANELLRGQLAVKRQTAFEAGFIYAPTIDGDLITDSPHTLLSQGQFAKKPFISGNNKDEGTRFVPPWINGTKFGLDLINLAEPIDPSNETLAQLIALYPNDPSLGSPFDTGNETFGLDPSFKQFAAINSDAQFQSPRRHFLQQANRHGNNHTWTYQFEQLTPGAPKYLGSYHGSEIIYVLGGVKSDLATSAGSNAKYSEVDQKLSEAMMTYWINFAHHHNPNGNGNGDSSTTGSANATYWPTYEDNSDNKNMLRLKSDNIKVFQDNYREQGMQFFLDHPKEFNARRRRWLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIA1</accession>
    <name>A0ABR3BIA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SEL1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610924.1">
        <property type="nucleotide sequence ID" value="XM_066761099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993532"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046499076" description="SEL1 protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="860"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="860"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="900" mass="99133" checksum="1774B504491DA06E" modified="2025-10-08" version="1">MRIYLPLLLLAAPFLRAQDVCAPLEDADRILESLQPAPDEHLHSKLPDLAPFGNHGWADGLGWSQDGPLSTTLRLLPRVFSAISPTRLLSQTAKTIGRKGNTKISRSRKERAEKVLELVQEAEGAGCDKVWRFRGRLLMFPPRGIKQDLAAAYEAYKEHLQIKSDPEAQFILGVFHSTGLGGIPIDQGKALLYYTFAAAQGYRPAAMALGYRHWAGIGVKEDCGVALEHYSHAADISYRRFLGGPPGGLTLPLTPIRLSDRVGGIYGPHASWASTGANSLRPAIRASIASARGETTQEILEYYQYHSDRDSYIYTARLGRLFYHGSVHFSANGVSSGAESVGAIPQSFQKARTYFLKVARVLWPTEFLPGTTDQPAGRRKLTKEQEDKVREAAMISASFLGRMALRGEGQKVDYPRAKLWYERAAELGDREALNGLGILYRDGLGVPVDLTRAQGHFQAAAAASLPEAQVNVAKLLLNRGDYQAALPFLDSALRGGNPLEAFHLSAQIHTTYARSSKSTSLPPAMCGVAVAYEKLVSERGSWNEDFLLDADEAWARGEEGKAMMGWYIAAEMGYEIAQNNVAFMREGGWQFDAEREGEWLIGKRREEEGGKQALVWWLRSAAQDNVDAMVKVGDYYYSKQDYPHALAHYLSASETQQSPMAYWNLGWMYQSGKGVARDWHLAKRYYDLSRETGEEAGLAVWFSLWGLYLQSWWTHFKTRGSISGLPLFEPPTPSDSDTPLGTWSRLKSLFTSPFQWAELQFDEDWENTLEPEGIVLGEGDLEDGGGALGEAGNGGAEARDWEGETMGEMVEDLLLIGLVFGIGGLMWLRARWAAMVGNGVGVQGQAAQAQGPVGGGVGFEGAEAFGAGFGPPQQRVQQDRPAQDNQRPQGPEDEEDERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIQ1</accession>
    <name>A0ABR3BIQ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611067.1">
        <property type="nucleotide sequence ID" value="XM_066760795.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993219"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="271" mass="28670" checksum="78B833601F8EA2F7" modified="2025-10-08" version="1">MSSARKRKSSSTTLSGPRHSIKNTASTEAPSDLAMSGSPIHIGMDDGDRGQEGTDDDVEGDQSSSAAAKRKMPAGAVARWRGRGGRGGGGGRGGRVSGGRQTREDTDDDEQPATKKKAKKAAGDVKTKNHLHNPHDPPSQVLALENFLARNSLVGGAEPAILASFVAMKHIGQADRRLRHDAQALLCKTASARSKNAAAVSQANEYRHQWGKSMSAGDAEILNWTRRQLQIANQDLDIVRAFAKKAAGVDVATSDVEAGPSTRALESDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIR6</accession>
    <name>A0ABR3BIR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611090.1">
        <property type="nucleotide sequence ID" value="XM_066760818.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993244"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="337" mass="35966" checksum="70C1A052AE2C5D32" modified="2025-10-08" version="1">MYALWRGWQRSFWPDTLRNYCCGGRLRGSEMGEEVETKERGRTWSPEQGSGEGTSDGHGNRDENGMRRKTVYFTDSGRQGVGRKGMVSTVGYHTSMASAGRPSGRQSVQQFGRQSSPSPAAHTQPQSRSRLPPYPRVGPANSGWVSNPGGEGSFESAASYTALERLDRESWAPYSPASTHTRPGPGYGYGVYSSPRAPPDYPRNTAVQSQSSYLPMIQAPRPHTPSTGIYYLPPGDPSSPNLPHTIAASLAPMNTRPSSARGSPVMSPSPSPSLPPLPEVSGESHEPIPMPTPSPPANHSSRVQFSPLPTPSQNGSACSSAGSARMQNGSPRSGQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ20</accession>
    <name>A0ABR3BJ20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_106483</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611183.1">
        <property type="nucleotide sequence ID" value="XM_066760911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993338"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047443437" description="NodB homology domain-containing protein" evidence="13">
        <location>
            <begin position="20"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="14">
        <location>
            <begin position="39"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0240684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="249" mass="27071" checksum="9920592715E4E7AD" modified="2025-10-08" version="1">MKFITTLFTVLAILSSVSASPTVKKRATVETIDNCSQQGTVALTFDDGPYNYEAQVASALDGGKGTFFLNGANYACIYDKADSIKALYDAGHTLGSHTWSHADLTQLDESGINDELSKVEDAFVKILGVKPLYFRPPYGNINDNVLNVLSQRGYTKVFLWSDDTGDANGESVSYSEGVLDKVIQNYPNPHLVLEHSPIETTSSQVLPYAVPKLKSAGYQLVTVGECLGTNESPYEFVGCPGERDSSWQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJH4</accession>
    <name>A0ABR3BJH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_106790</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610749.1">
        <property type="nucleotide sequence ID" value="XM_066761209.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993643"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="5"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="407"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="918"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="460"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="725"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="922"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="950"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0240241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="962" mass="107477" checksum="B9D197AD19EB6955" modified="2025-10-08" version="1">MSGNNIKVVCRFRPMNRMEIESKSEQCVDITEDHTAVQLRNKASLAGPEKDGFTFDRVFDTTTRQDEIFDWGVKGIVEDVMTGFNGTLFCYGQTGSGKTFTMMVCDKGADIENPSLRGIIPRIVEQIFASILSADSSIEYTVKVSYMEIYMERIKDLLAPQNDNLSIHEDKQRGVYVKNLTDVYVGSEEDVYRVMKAGGASRAVSSTNMNAESSRSHSIFVIGIHQRNTETGSQKSGNLYLVDLAGSEKVGKTGATGQTLEEAKKINKSLSALGMVINALTDGKSQHVPYRDSKLTRILQESLGGNSRTTLIINCSPASFNEAETLSTLRFGMRAKSIKNKARVNVEMSPAELKALLKKTQAELVGIREWAAKLEEEAKIWRSGGKVEQINWAPALNQALAGDSAAANAAKRAMAPPPPPTPSSSSASRAATPGGALGAIDGSRPDTPSTFSLGLDKDEREEFLKRENELSDQLAEKESALAAQEKVLADLKEEIAYFKDQESAISQENKTMSFELNELRISSARLESEAKDATITLDSYKEKIAELQKDIEDQKTEIENLKHAQTREKEEEKEKRKQEMLNEMMSKIDLGGTLDSSSEKLRAVLRELEETSDAERKEKLTSQTRELIRTSLAESQDVMRGLQERLRLACEEQDMQVKRRSELEKMLEKRDAAFEELLEKTASGQGISFAEIKSSLEDKYSSREGLLRTEISTLSDHVESRAQDVRRLQSTVESYKLSNEELNRALTAATIGTDGETFASSAKELERARKAHEIQYAEFEMVKKSLMKDLQNRCEKVVELEMQLDEVREQYKIIARSANSRAQQRKFEFLEHNLEQLSAVQKQLVEQNTSFKKEVAESQRKLMSRNDRIQNLEAALSNADQRLAQKNQKYEQQIQLFREKLAEAQSKQNATYAHGRIAKPLRGGGGAQTGVEGGIQGIMGGGKQEESPSGKRQSWFFSPQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJM2</accession>
    <name>A0ABR3BJM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tricarboxylate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611372.1">
        <property type="nucleotide sequence ID" value="XM_066760611.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993019"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="207"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0241990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="31974" checksum="36CB4DB9A963212C" modified="2025-10-08" version="1">MAPMEKGFSWSNIAVGATMNMFEVTTLGQPLEVLKTQMAANRSQTMGQAFKSVWSRGGFKGFYQGLIPWAWIEASTKGGVLIFTSAEIEKAAVKGFNLSPAAAGMLGGIGGGIAQAYATMGFCTCMKTVEITRHKQMSAGAPVESTFKVFHDIYKREGIAGINKGVNAVALRQATNWGSRFGFARLAEAGLRNVKGIKEGEKLGAMDKILASTLGGALATWNQPIEVVRVEMQSAIKSQDPSRPAKKTVLNTFSYIYKTNGIKGLYRGVAPRIGLGAWQTICMVSFADYVKAFIGTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJV0</accession>
    <name>A0ABR3BJV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611450.1">
        <property type="nucleotide sequence ID" value="XM_066760689.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993111"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034444">
        <property type="entry name" value="Nuo17.8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="175" mass="19758" checksum="DB462A1666D223AF" modified="2025-10-08" version="1">MSLRPLFRHATTLNSARGIATSAPRRAAHRDHHGAEDQSDTYTNESFFSPSWRNAFIILTASILIYPYLPSPSHKPVSPSLDPEAFAAARKDETLPALTRWFAKQTEKAEVWTQRNDKHLELTKESAETKLLFQEGERPKVMRMRYPSSFEQASPHSIAVGSQADLSDLKIRPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK11</accession>
    <name>A0ABR3BK11_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611512.1">
        <property type="nucleotide sequence ID" value="XM_066760208.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992614"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="341" mass="36691" checksum="EF7CEA85AF2B84BD" modified="2025-10-08" version="1">MTGKIIATVTAAIYTVFTSPHHAPMPNHLPTLIVTPHGQPNHILYTYLHTEENRVNYLLTPSPQGDLCVAKLFPPPRPSAGHSSATLPTVSHKQAPNAVHCEASRDLRWTIENTGVMSPIYKIVNQDDTPLYQISKPNPNAEFWTMFYFKYAGHQIPPKRIEFGKISKNPPEKGGGTRLSITGRTEDEKQVWQTLGVGNEDCVEWVVCCACLNLLDDEILRAAEKRANPNASGSSSSPASTLTSPASTTVRPVPAPLQRVGPAPGPRSASAALGPGIASSAPASTGPMQPMGGHPAMNLAQTYRQNPPPMRGPPARPGQVQPVPQGYVSAPPAGQPHRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKF4</accession>
    <name>A0ABR3BKF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Histone deacetylase</fullName>
            <ecNumber evidence="2 8">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105893</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 8"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611646.1">
        <property type="nucleotide sequence ID" value="XM_066760342.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992748"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="10">
        <location>
            <begin position="56"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="426"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0242264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="475" mass="53236" checksum="BC2FA097C9C45C31" modified="2025-10-08" version="1">MTLTEYPTFSSSPFFYDPRNPVLPEAEESHIRAHSNPSVAYYHPKNVGNYHYGERHPMRPHRLELTNQLVLSYGLHEKMSYHAPRAATEEELLQFHEADYVDFLKRVTPKNAQALTKDWTKFNVGDDCPIFYDLFSFCKQYAGGSLAAARKLSSGSADIAINWSGGLHHAKKGEASGFCYVNDIVLGILELLRYHPRVLYIDIDIHHGDGVQEAFYLSNRVLTVSFHKYAADFFPNTGNLSEIGSDLGKYFCLNVPLQDGIDDESYISLFKAVMEPTITIFKPSAIVLQCGADSLGCDRLGTFNLSIAAHGECVRFIKSFGLPLLALGGGGYRQSSVSRCWTYETGVLAGVQLSNELPQNNYYEFFAPDYKLHPPLTGKIQNLNTAKSLERIRISIREKLRYLGGAPSVQMQEIPPDLQGLLEEDEKSAAEKMDERIEERREGKGKETDWLDREVGGSGDGVGSGRYFGGARRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKH7</accession>
    <name>A0ABR3BKH7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_105886</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611639.1">
        <property type="nucleotide sequence ID" value="XM_066760335.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992741"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="30"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0242257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="151" mass="16479" checksum="5FDA064E01BB3FC1" modified="2025-10-08" version="1">MAAPAPPVAADAARTADPSAYSGESTQEKKLLYTFETLAQHNTREELWMLLHDKVYDVTAFMDEHPGGDEVLLEEAGRDATEAFEDVGHSDEARDMLKKMYLGEFQGEKKGKAKKGSSSTGTSSSSSSGFPTWAIPLALFVAFLAWRLLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKL2</accession>
    <name>A0ABR3BKL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF300-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611719.1">
        <property type="nucleotide sequence ID" value="XM_066760415.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992821"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0242337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="793" mass="88201" checksum="0D22F814D4250C5B" modified="2025-10-08" version="1">MSTTLQQGDTDAGAGNHLPVWLLAMSGIFTAVATAISMMSIVLQLKNYRKPTLQRAVVRIMVMVPLYAVSSLIALFSLDAAFFIDAIRDLYEAFVIYTFLQLLITYLGGERSLLIILHGRPPIPHPFPVNIFLQPMDVSDPWVLLNLKRGVLQYVQVKPLLVLVVIALKATGTYQEGRFATDSGYTYVSIAYNASICLSLYCLAMFWVAVNKDLKPFRPVPKFLCVKGILFFSFWQSIGISLLVAMGAIRKVGPYTGPEHMSLALVDSLICFEMPIFAIAHQYAFQASDYIDHDLIYAARLPFIYAFRDAFGFKDVWQDTIDTFKGRGVSYQAYEPAEGGLHYGVGRQKRIRAGLRYAKGGKQKYWMPKPGDEARMKGQNGLITNMKRKVDERLAQREGYAPLLPQQAARVVHPDPGRYSPYTSGQRMFDSDSSDDSDAPSLTFHSADEMEDAMYERARRIGYAGFPNVDVSKEEAKRRRREEEEGILKGRWTRSGLRVRDGMGLGGEDGQGGGRGRASSASKSKNNSKSKDKGKGKAKWKGESRKVYGTWADHPPSLQRLNSSSSSTRNGNGHSADFDEVDDGGITQQPQGGPIQKQRSPPVWVTRTGTGMGMGVGSSSSPFSIGDDDDDDDDGEEHVKKRNDQGNKSVSPSHPDDYHRNSDSDKSVRPSTTKRLPPDAVDLVKEDQEAVEAARERERRRGEPQTNAPVHVYRKTIVDEIPETDSNASAMKRRGLGGKMEEIQEVYAHDPHVMTEDEIRTGVKEVVDHVETSVIIDPPKHAMSQDLEDNPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL50</accession>
    <name>A0ABR3BL50_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611545.1">
        <property type="nucleotide sequence ID" value="XM_066760241.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992647"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0242163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="145" mass="15700" checksum="DE700E325FA50BDE" modified="2025-10-08" version="1">MTCNCFSEKTTSRGSTSKAQAKCTCQKGQCECEACPNFTKASGPGTCGGVKERLSTCGCNGSDLEHLRITATDLVKHAHVLPVNSFSSRASGQRLVELVAAKEQPHEDRALGMVDDEVWWFKKKSTPALAEDRVPPELIFHTSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL52</accession>
    <name>A0ABR3BL52_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611892.1">
        <property type="nucleotide sequence ID" value="XM_066759946.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992346"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="766" mass="84637" checksum="059EC25DB1582B12" modified="2025-10-08" version="1">MPPTPSTDDVTPQSAHLLLASLRNLRTSLTHTLDRLDATILRVHARAALSTLPPQAALGNPSHAPETAPHISGNGPGEQPMEARMQTDPWVLRAQTVENRIMRLRQTARELRERAEANDGRALPASIDQEPAVRVMESANNDGNGSQSISAFIDSIRQDQAQVENGMRRLDALSTHLISQRPNSSSAVVNDINVSSRPTSNVIRPSTPRPYNHPRGLAPTNNLYAYPDPERIASNNVSGRRASSAASTIRASDRDYFESGNAGPNIGSRTYSPPRIVSNVQRESGAVDNQSLETLEWHGNSPSIRSVATLSRNGGNREFDFRSLFDFPLESPVPFGGVPSSNIRTRDVNNGGNAAEDSLTRRGRTVHQRMNNSQPQPQPQPQLPQPGSVPDIHALRRFNEVNEQPSFFRPMTERFSLSPLEATALRRLGSQERPSSAELQMGPFRSVPDDVDPSRHDNARPNTGTTQSPGLNSTSLPFNQSTLPPRNTQNRDDTTFEERMERIRNARASLRQVSQLRRDMRTVRRGPPPAPGMGMAEQPVASVDTTGLRGEIQVPLTRDSDVNQDPRRRNSTTSTRLTPSANNRLQLDPTDPTDPWNNDTSFQGAMETLHNALAGELGRRHWVVQSETVDGNDGERRRDRDLVDDGIGLDVLVLEVGVAEQRPTPEQNVTAADVGSTPAGDAMVRSEVERGEELLEDNADEDQEDQDEEQVSRERRDIGLSSRRVSMKECYQVDLHLWPGITGWGNKRKEGTSCREVTIEPLQFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLB4</accession>
    <name>A0ABR3BLB4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611952.1">
        <property type="nucleotide sequence ID" value="XM_066760006.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992407"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12276">
        <property type="entry name" value="RRM2_MEI2_EAR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="93"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="424"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="510" mass="55675" checksum="61EA6DCB33EA0764" modified="2025-10-08" version="1">MSGLPPPSSSLPPPPRFDHGREDNYHARPYDGSRDRDYDRNRDNWERDSRRDHAYRGPGGPRSRTPEGRGVRRLYDRENRSIEERIQQERPCRTLFVRNVQYDADPESLRLQFEAFGQIKNFYEMVSKRGMIFISYFDTRAAQRARDAMHGTLVNRRPIDVHYSLPRSEEVTGACTAEKNQGTILVSLHPSRALDLNEIGRIAAQYGDIKDVVPGRVPSEIIVEYFDSRGASLFQQQMDRQPLLGGELELRFIWDKLDSSVPPPPAAVAKASRPPSDYDDRAKGPPARRDDAYNNSQGGRFGSRGGPRERSPDYRGRRGSYEAGYGGPPSGPSPGRYHDAPPAPASVTEDRLEQALRVQQLLNKIGNVNVPPVAAAPPAAPPAPSYYRSPPVMPPSTASYPPQGASYPLYNPVPAPNAYGSKPSYAAPAFPPYPPPAAAGPVPPEVMGSLPGRQPPVGYGGAPPPLPPLPSFPPAGPTAQSIPPVAAAAPQGQQPVKDVGSLLAMLQGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLS7</accession>
    <name>A0ABR3BLS7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612113.1">
        <property type="nucleotide sequence ID" value="XM_066759466.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991862"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031440">
        <property type="entry name" value="DUF4670"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21937">
        <property type="entry name" value="CCDC66 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21937:SF6">
        <property type="entry name" value="CCDC66 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1089" mass="118385" checksum="304C3D6804741A37" modified="2025-10-08" version="1">MSVDLSHPDIAAARASICNPSEPTAWLVLQYGSAPSTTHGPQLVLLDSGPLPVLPTWQHLLQTTGHSILFGYVRIAEKGLLLVYLAPDVGGVKRARAIVHSRAIGSLFPDYSAIITISHASELTEQLIADKLALNRPSTTPLPGAAPSAPTQVVPGPDVLGPDPLPPRAAGMGRDLPSLPFPTSHPQSLETTQLQTSQLQTSQLPPLPPSPIPPSPVSKDETGANDVNDVDDLNDRDIKKETTLEDEEHEQKHKPENGHGLELANGNGKGNLSTNSSTRKPVPALSPSPPPPPPPPHSQPRTPPKPQPVLLPSAHTPTIHASAPPPASPASPARGLGGTASTRKPSTPLSLTSRLKNTFHRSSHKDKDSPTPIPSSPTATPSSPSIPWSANSTKPDVQHSPTFPHTTPTPHSPNTPSGGKFKASSLSKVFGKRKSAGASTSTPSGTGTGTWAGADGGSKIVEESEEDRIDEFGRPPQTQNDPSVAFPSLAAAPTPPPKSPLPHLSDRSIPPGPTDDLNPGLGLGQGLATPPPPRGSSLHPHHPSPSSPSPGAQARQNTTAGNAPLPLAGVPILGPQVPLPLLPPPPTFSHSHRNLDSSLERAGSPYYTPPLIHPSPAFDYQEEGTHPSHLHPHMQIPSHSHPSTTTTTTTTTTTTATVPTTLQSPPSRSTSLSPSVPPTTTTTATTLAIPSDPVSIPTDAHDTVANAKEDGGEDVEMEQRNQQDKARESILLAYDLPEIRPESDPRQQEKDESAVIEIAEEMESGLPPAQRQGEQCNTPAPVNDDIPATAHPVEEQAGEGEAEIPVEMEDAKAEEEGDDTQNKKEEGEEEERQRLERQREILEAQQLAQWQAAETARWEAEESARLQREEATREAARLAAEEQARRDAEEAERFRLDEEERMRAEEAARLQKEAEEEARRQVEEEQRRQREKEEEEKRRMEEEERRKREEERRKREEEQEQERKRKAEAEERKRTVRDGLERGKQEGGVMLKGWVTAQTCKSLTWRRRYFQLFSHEMQLFKNENDIKPIQTIPLSKSTRISEAYEESQVKDSFKITSGDDDEGGEVFFLFTDSAEDKEFVLDGVRLCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLU9</accession>
    <name>A0ABR3BLU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611758.1">
        <property type="nucleotide sequence ID" value="XM_066759812.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992211"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24412" checksum="B79D2111F6BCA744" modified="2025-10-08" version="1">MPNNRRITKKTIKGKEGLHPGSRKAAQLTRVQLRVEKLKGNNKARKDHVAARVQRPLFFIHSLSSPNPLTLSSLKALITEVYLKRHDPRIEELIRERRPGRPKPKELLDLEEVKRRETGEYETGMEVPDLTHPPTTLLIHSWLSAPNPPSIDHSHIDLLRHIRVSPNGDVLLTKEGRTEEMGLGNWKGEGEGDDWTSFLEGVNANERQGQEMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLX0</accession>
    <name>A0ABR3BLX0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SBDS family rRNA metabolism protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105052</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612158.1">
        <property type="nucleotide sequence ID" value="XM_066759511.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991908"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="9">
        <location>
            <begin position="108"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="10">
        <location>
            <begin position="173"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0243791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="243" mass="27275" checksum="09ADBDE3FD17CD10" modified="2025-10-08" version="1">MLRQPGTQIKLTNVSIVRMKKGGKRFEIACYQNKVSEFRSGVENDLSEVLQIEQVFTNVPKGLVAKKEDWSKCFGTDDMDKVIEEILKKGELQINNLERTQHLSSLSREIATIVSEMTVDPSTSRKHTVGMVEKAMAEVGFSVRADRPAKAQALELIKKLGEGDVLQVRRVRMRVRVTMPGKDAKRCKDKIVAECDEVEEEDMGMEWEAIVQINPSTFRTLTDLVNNETKGKGRVESMGSVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM05</accession>
    <name>A0ABR3BM05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105086</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612191.1">
        <property type="nucleotide sequence ID" value="XM_066759544.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991942"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045319528" description="GH18 domain-containing protein" evidence="10">
        <location>
            <begin position="23"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="151"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0243824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="519" mass="54775" checksum="382C200C2207330B" modified="2025-10-08" version="1">MYFVRRTTLFAILTALTVRSAPAPQSGTDYTCDSDKQWHDAYQTVTCPGDTVCVTGASGNPCQFPSGYEQSAIVAVAVTSASAAGGVTSATVAGGISVTGTGKTGGGGAASPSSGEEVTTARSAVASSASHTNSAASPSGTSTSNGASGSNRFVTYWDNYANMGGVNAAQLTAVTHVILSFADMTNWATKQTTWQFMESSDGNFDSSTAATLKGMRSGLKVCGALGGWGLDSVMATAVRGGDSSIATFVANVKGFADYFNLDGIDIDWEFPSASDDANLITFVTRLRAALGDDKLISIALGARVDTTDAAAFNSDTFSKLDGLVDMWNVMTYDYVNRYSTTTEQQAGNRVVTTVMDYYEKQGITMEKCNVGFPMNAKYFTLTETCDSSNPIGCSLPGRTYYEDNGVDNYKSGWVRFNPGLDSTLGTKGTEWAIKMRAQWGARPTDGSTEITADVSNAWVDETNNVFWTWLSDSDMKKTCQNWVTSGKVGGAMVWSLNQDDKGQEGGSHMAALASCIQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM55</accession>
    <name>A0ABR3BM55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611905.1">
        <property type="nucleotide sequence ID" value="XM_066759959.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992359"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="456"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="836" mass="91888" checksum="5B689C674992E5AE" modified="2025-10-08" version="1">MDFSHPDRKSDAEFQEILDTFVGDQKTVLTGSLPDLLAGYEKDHNMRILEEADFLGVKDLCEQYPDLELGPVDLFGFLMAALQREASPAYINSDNAPHPGDTIPEDGLRRRRISDRIRSPSDDSNSSSSGEEDDSSTRQGSAPPESQNPFQSSTAAAGPAGFAVPVRKKILSDPNRSDSSLDSPLPARMRSRDSTPSAFTGGFARPSPASRRRTASSIIHLDDDLNSPDLSNPIKRSFSSSSIRMQSPRPQNRLSSHHSSRPSSPMSAVDQIDSASSHGRTKSPDTDDCGSEAVDQIGRKAIADFGLDQMEDEEEREKRDGDDRDANGNDTALSRLNRISTESTASLHTSHDQLRRLRKENNDLLRKLKETEKSLALQGAENERLVEDLQARLEETQSEIAQRRKDEKEMRGKDRAQLIQISGFEADILSLQRSLENARVNHANMQKMYNSQCDEAQRLRDMLRDRDREIRELEEAVNAHSTDEEKLTQEIQALENEVKRLEADLSQARHAESHLQVQKQENLVLKETIDRMRFDLDEARAAAALAGGGTGRNAGSAAASSAGGTLSHNLGDELGRRLVAVEHVEEEEVEDAFVETIVTTQRTRKVGGRSGQSTSSSSQSATVHIEEGIREYIDASTATDSTLHEAIPSEPPAYTAMAPPINSDQVLQRAHPRDHKHLEELLGSGEAVVEGEEEYEALVDALGVRCTVLEDEVKMKKFERAKHGGGPVLRRHTRHSWTTDQATGGIIQFFSYGTNDFRDALGRFAVFAVAAFAFGVIAGPHLLGPSTTGLHPRDYKLFQQMNTLAGVAGVGEGFLPAHMLGMVENGARLVAGRIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM64</accession>
    <name>A0ABR3BM64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="12">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PIF1</name>
        <name evidence="17" type="ORF">I308_105941</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="12"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611694.1">
        <property type="nucleotide sequence ID" value="XM_066760390.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992796"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="14">
        <location>
            <begin position="6"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="15">
        <location>
            <begin position="188"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="15">
        <location>
            <begin position="265"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="16">
        <location>
            <begin position="489"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="12">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="209"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0242312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="691" mass="76704" checksum="15D1BB758B1E9833" modified="2025-10-08" version="1">MPKPGFYAVRCGRRPGVYITWAECQQQVHMFPGAIFKKFPTHDEASIWASLRPQTPPLRETLRTNHKDDLKEPDDGKCNNDSPQLSSQRGRRSSFKSSSSRTLCLSYQKDFKRERSADASDTDSLGKKAKVGKHDHCDDGNECDGFTAMDDYISVLPPNGEASESSSIQVDGDTATAELPAAGGEPELSPQQSEILAKIMNGENFFFTGSAGTGKSVLLRAIIKAFKEKEEQREQREAARSFRGWQGYREANKVEKEEVVKWSLAVTASTGMAGVNIGGTTIHSWAGIGLGVDNAEKLAAKIRANAHSRKRWRSTAALVIDEISMIDAPLLDKLDRIGRIVRNDGRPFGGIQLILTGDFFQLPPVTKGQIPQFAFEAECWPKLFSHRNIKTLTRVFRQRDDRFVKMLEAMRRGTVTLDDTALLQSLNRTVKYPDNIEPVALYPQKRDVEFVNSARLDALPGAITVYDCHDQPGFTAGGFPITKTEATAKLNKNTIWPQQLSLKEGAQIMLVTNMGDGVLVNGSTGTVVDFLTIPDAIKRGIHLPEAAIKGQTSMDLEFPVVAFAQSKFARKKVPERVIIPSMSVDILNALGQPEATRYQIPLILAWALTIHKSQGQTLERVKIDLAKIFVEGQTYVAISRAVSLDSLEILNFRPDSVKAHSKVINWARPYEEEQAAEEEWNNLEDNIGILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMI8</accession>
    <name>A0ABR3BMI8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612368.1">
        <property type="nucleotide sequence ID" value="XM_066759721.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992120"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="305"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0244001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="381" mass="42776" checksum="3E4A28D9430D09F8" modified="2025-10-08" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMR9</accession>
    <name>A0ABR3BMR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611919.1">
        <property type="nucleotide sequence ID" value="XM_066759973.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992373"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="115"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="267"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="392"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="514"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="69792" checksum="A84D2D0F0DC0302F" modified="2025-10-08" version="1">MQAIKLGKKYPDFKQDEIFDLINKFKQIDVDDKGSLDKATVISALQANGEADYDSARETLKNVNIDSSGRVELEDWVQLHSLLKAAKNQPLLEHNKGRISVRGTAGTNAQHTINEDERRSFTDHVNTVLAADKDVGHLLPIPTDTMQLFDECRDGLILCKLINDAVPETIDERVLNKPSVKAGKARPLNAFQMTENNNIVITSAKGIGCSVVNIGPQDLIEGREHLILGLIWQIIRRGLLSKIDIKIHPELYRLLEDGETMEEFLRLPPDQILLRWFNYHLKAAGWHRRVENFTKDVSDGENYTILLNQLKPDQCSRSPLQTSDLHKRAEEVLQNADRIGCRRFLTPNSLVNGNPKLNLAFVANLFNTWPGLAPLEETEAPPPIEDFDAEGEREARVFTLWLNSLDVEPGVYNLFEDLKDGTVLLQGFDKVIPGSVVWRRVSKPREGQELSRFKAVENTNYSVDLAKANGMHIVGIQGSDIVDGTRTLVLGLVWQLMRLSINQTLASISKDGKGVTDQDIIRWANETVKKGGKTSAMRSFKDPSLSNAIFFLDLLNGVKPGIVDYSLVTQGADEEEKRMNAKLAISIARKMGALIFLVPEDIVDVRPRLILTFVGALWSASLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMW7</accession>
    <name>A0ABR3BMW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104543</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612503.1">
        <property type="nucleotide sequence ID" value="XM_066759016.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991399"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="101"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0245419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="607" mass="65920" checksum="C59BDDF32805B2D9" modified="2025-10-08" version="1">MSTIASPPYLDDNNPGTACARPNLSKPTVRETPMSDHNPTASSLSRPIPLNQPISSLSISTTLCPPPYPGSGTLCDPYIVDFLPSSPINPYNWSKRYRWAITALIGVTALCPPFASVSYSSTVGEVVKAYGISRELAIAGISLFILGFGVGPLFWAPISELYGRQFAFAASYPIFTIFNLGTALSHNTVALLVTRFFAGVFGSSPLTNAGAQVGDMWAVNERALATSVFALAPFLGPVLGPIAGGYVTERCGYRWVYWIQFIYAAVMTILSIIVVPETYAPTILRRHARSLQATALSEGKEEYYISKYDMVKRSKREVILVGLYRPFEMLFTEVIVGCLSIYGALIYGILYLFFTAFPIVFQQTPGWTIGESGLSFLGMGVGLISGVILNPFLSSYFHSRSRSQLQSHVTPSGHTHPHPPPEARLPVCCIGAILAPVGLFWFAWTSAPPVHWSVPIIACLPFGLAFLLIFTSMTNYLIDSYELYAASALAAQAMYETLGLHWAGTLVAFLSLACAAMPFLFYRYGSYLRRKSKYAPSVPSIASDKASETEQVGAKDEKNEGQSTVNGSRSELQAGGIEPEWAADAGLDAHIGGFGERKRGWDVEKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMZ7</accession>
    <name>A0ABR3BMZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612509.1">
        <property type="nucleotide sequence ID" value="XM_066759022.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991405"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="335"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="699" mass="76467" checksum="2E714B1E28F58A95" modified="2025-10-08" version="1">MPPLQFQPLASQPSPSFWAALSAHKLNHLKLDDSQLQIRAYLEPAKRILINKENAADKADVGIDGSLVVGGEAFEDEGGNLPPNAVSVSGTLKIFNTIEEFKDTSTKKRLFDDIVSQMLESFDTDQPMLNPFLLVTFADLKKYVYNYWFAFPALVSSPAWTVEGEFIPIDEIEEIRNLAQSQNRNNATAFLLKGATSQLSAAPLSSCSTFYDKAQGETVTVVFHDTSSLPSNPGWTLRNVLYYLSAKHGVTSLRVVCLREGSSSIQASLSLPPPSYPPSSTTPSTTTPVPSKPPQAVGWERNPSGKLSPRVVDLGPMMDPTRLASQAVDLNLKLIKWRLLPSLDLDKISGTKCLLLGAGTLGCYVARILMGWGVRDITLADSSTVSYSNPVRQPLFTFSDCLNGGLPKAPTAAKKLAEIFPGVNAQGVVLGIPMPGHPISSSSDVDASHTVEEDVAKLEELVKSHDAVFLLMDSRESRWLPTVMGKKWNKVVVNAALGFDSFLVMRHGAGRRRTQPGELEGEGMGEGEKKERKKGLGCYYCNDIVAPTDSLSDRTLDQMCTVTRPGVAPIAAAMAVELLISVLQHPLGVHAPAERPDTMDASTGTRASPLGCVPHQLRGQMYQWKTQIVEGEAFDRCTGCSDYILNEYEKNGFAFLQRVFNEKDYLEKVTGLDDLYRESEAVIERMEGLDWDSEEDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNN2</accession>
    <name>A0ABR3BNN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612770.1">
        <property type="nucleotide sequence ID" value="XM_066759283.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991676"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0245686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="318" mass="34692" checksum="07D7C80992FA4020" modified="2025-10-08" version="1">MSLLANTVRRAPSSLQLSTRNLSTTSVCLAETAPAASRYVRKTAVPARAKPTAYSRPAAFNSASTVASRARPAPAPRPLVDEFPEHLPLPSEPLIDDYAHLSAPPSAKVSPPLSELPNENYESLPSATASARVGGKLAGEAPVGLDWSTSFSGLSEKPFAKEAADELLKPLAPEDVEIKPDGLLYLPEIKYRRTLNAAFGPGGWGLAPRGETDVGPRIVSREWGLVCLGRLVSVARGEQEYFDPSGIATATEACKSNALMRCCKDLGIASELWDPAFIRDFKKQHCVEVFVEHAVKKNKKKLWRKKNRDKFEYPWKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNQ6</accession>
    <name>A0ABR3BNQ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612764.1">
        <property type="nucleotide sequence ID" value="XM_066759277.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991670"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0245680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="252" mass="27211" checksum="370F1AD5A1FEA25C" modified="2025-10-08" version="1">MEARLQKLKVTDLKELLAKYHLPQTGKKDDLVKRLIENNISDEGPQEELTDPDAPLSGTNVPKTIPQVTAAPAAPNTSLIDPSHTSAASASELPAVETNNISASAPSAEPEIELTPDQKAMKARAERFGIPFNLPKPSATKPSKTEKAETKATETRQKAVPIDKNPLGLSEEILAKRAAKFGLPEKKEAEKPASKPEKKAEEVDPELAVKLAAEEEKKRKRAEKFGLNKPPAVKETEGQNAAAEPDAKKVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNY2</accession>
    <name>A0ABR3BNY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612866.1">
        <property type="nucleotide sequence ID" value="XM_066759379.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991774"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="155"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0245782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="670" mass="74337" checksum="42FFC9149B4D1590" modified="2025-10-08" version="1">MSEKKKSNGTPGKRRLSFRSESESLEKKAKQEQFDTGDLVIREVYSSYADGDPPSTVSSSRFPQSISSFSSPSSTVDGDDRDRLQQFLPHPSNSIRHGSSSTVMSQHHQQTAGWSNIESGKSSLLTTSQSQSSSNPPITFNLSTDQPLVNPPQKTQAAFVGKLYSMLEDEDIAKTGLIYWSAKGTTFTCPNPTEFSKVVLPRYFKHNNWHSFVRQLNMYSFNKVNDIYSTSTDPQAWEFRHSLFRRGEAHLLPSIKRKSSRSSAPDGSNTVASPTDELPPNTSNPVKPVAGWMRDAVPVPYRMLSPPHIHGQPQKSATYPYSDGSTTRKDDGGLPARGITWDPLPAVQRMPPPLDNQIPIRYHPDPNRPPLTTQYFYRSGHTESPLYGPGHLPGAETLLNQMSALEDRVQKLTDVLNNDRIEHVRNNLDFTSYLLQMVGWAAGDQRDSPELRALQDTLSRQNAEMRHKYEAFMASDALAIMANGGGRERSDSRDITHERNARLGFEIPPFPGHPRTSVMDLHLPQSAQSSSLTLSQRAIPRSSPRSSMYSDPLLTRPSTGEPMRKREVYPAYFPPQISHDSGAASSILPRGPETIAAPVYGDGPSVHPPLYGSAPIIEDHREAEKGGEHKDMDGPSMVELGRKEREKGDPRMAVVGDDAESKTGLRNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP39</accession>
    <name>A0ABR3BP39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612922.1">
        <property type="nucleotide sequence ID" value="XM_066759435.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991831"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="811"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0245838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="947" mass="103565" checksum="AC8849A4E08631A3" modified="2025-10-08" version="1">MSRTATATPPPQTYFPQRNATPSMRHAAPSPAMHFGRHHQHFGHSHAKKRVKSYAGSGLKKQQMPQNSREQNEEDQLEMSFEDLGVERVLQNPNSDKADIDIDVDPDPNLTPASSQASIISGLSQDQGPVLLTPAQSDSEGRAPVLVSNSGWASSAGSEGSEEEGRASPGWMGKMAMAVVNTGMSVSRGFGQGQAQVKKVQSQSQSQAQAQGQAQTHPAQKIDEEQRQREWAEAENRRIHECARLCSQWPLSGYNLGKYGPNGAATFYQPQSFCNPQHVAWVMHRQAQIEQRLALTEETFFDCRKVRERKGQGGCENGRGCRAREEDEQSEVSTLTDDSMLSSRLSGSTCTTDSRSNCTANSSSPSSSQEETNSGPLSLVQPQRPLAPRSLTDENYAYGRTVQKMEREKEMAEDLREAMACSLLEFSHPERHASLTPSATSKVGVNGTSEHEKKAENAEMEGRRERGRKMFVELEALARDVGLGHAGEGMDVDEELREESQPRPQPDTQATLSAETHAANDSSDRSILRTRQQPAQSYGAKRPIPSKHTSADGEEEKRRKVEEAVDEVMVVEEAVDNGVIMPATQTPSPSQSHAMENRFKAGRAKIMSSSVPDLTKTYSQPGSATTYPPQRQQQSQPSNSRDLYPPPAVFGVVVKTSESHPIIISPFFPKDLLSVLAEHLVLPLGGGRKPLLLSSKLDVPSLLLSYSPGMPFPPSCSMRSQPQSAQTQPVSNPYQGPLVPALGRGPVCRDISTDLKRIKGEGVGCLVCCLDDEELELLGVPWETYRDVAAETGLDVIRLPMPDGFTPVSMELFDSQVSLIATKYTLQGINVLVHCRGGVGRAGMTACAWAIKMGFVQPHPSLVIVEEAARQRYNLIHGISPSSNSTTPIAPSAAIPAELEHQIVMSMVERVIAMIRCRRGLKAIESFEQVAFLMRYVGWLRQGARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP77</accession>
    <name>A0ABR3BP77_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105377</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611778.1">
        <property type="nucleotide sequence ID" value="XM_066759832.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992232"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="174"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0243411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="588" mass="64809" checksum="7D81C1811C8F0838" modified="2025-10-08" version="1">MSRYNDYRRYKRSADNSILPTTNQQYGPSASTANPTNSLLPPARYSASSASLDSRARQAELGAASSEEWEPMMAGPEDDDWMHNPDSNKDLSYDRGTIFTARGFLNVGCLFMLILCLVTLFAGYPIITHLTETPIKTNGAYNIGGINSTGQVPLISNIPSAIDNDTPQEAYTRTGFDGKTYNLVFSDEFEKEGRTFFPGDDPFWTGVDLNYWPTGDLEWYDPAAITTKDGHLVITINQQEIHDLNFRSGMLQSWNQMCFQYSIYIEASVSLPGNNNVGGFWPGVWMMGNLGRPGYGATTDGTWPYSYDSCDYGTLANQTNPQGTGPEGALTSGANDGPISYLPGQRMSSCTCKGEDHAGPDVTYGRGVPEIDVLEGQIDLTVNRGQVSQSAQFAPFDAGYEFLNTSKGAIQYDTDITIWNSYKGGTYQEAVSSLTYIDSNNYVGTSGKFGIYGFEMFSDPNNRNSGYITWVADGKKSWTMYPAAVGPLSSMNIGQRLISEEPMAMVINFGMSNNFQAIDLNHLTFPAEMHVDYMRVYQRSEGRIGCDPDDRPTAAYIKKHPNAYNNANLTTWGMAGYTMPKNSLIDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPS9</accession>
    <name>A0ABR3BPS9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104657</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612609.1">
        <property type="nucleotide sequence ID" value="XM_066759122.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991513"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="516"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="82"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0245525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="559" mass="60561" checksum="4E7FD57B2FE66C82" modified="2025-10-08" version="1">MTENEKHTVQTSTLHEEVDAGLVGESAPYAQAPALMQITSQNNMSHLDITTSTEKGEVNGKQPQHREQSQTGVLTGARLYLVFVALMLCVFMFALDQSIVSTAIPVLVSDFHAFNQVAWVITGYFLTQCGFILLVGQVLTVLKAKWMLLGAIFFFELGSLICGVAKDMNTLIGGRAIQGIGASGMFVSILAVIAVVTRVDQRAAFMASFGFVFVISSVVGPLLGGAFTDNVTWRWCFYINLFFGGFAAAAVVFLLPARDPEHAETAPDRTVFGKLRRLDWLDWRIPFLFTLGGLLVIAFGMWQWRYDKYALIPLSLLKNRTVIASSGAIFFFMLAMLGGTYQLPLFYQAVRGHSPEKSGIDIIPFMLATCVAILISGGVATKFGRYYPFLLIGPPFAAVGFGLLYTIGVHTSNAKIIGYQILAGFGIGLSFQNALVAVQAEFHDRPSLLPQATGVVSFFQLTGAALGVGIINTVQSVYLNTEIKLLAPEVDFNLVRNSVSAIYTLPADQQPAVIEAYVISITNSLIPIIVAVGLAMVFGAFIRNHNLLKKRAAGGAHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ61</accession>
    <name>A0ABR3BQ61_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613141.1">
        <property type="nucleotide sequence ID" value="XM_066758693.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991071"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="491" mass="51688" checksum="3C9BE8CE23812DB1" modified="2025-10-08" version="1">MSQDNAPSLLIPPNPALLQQKPSASILLNGPNRPRGPSSSTAPDSASPRSLSASSFTGSHSPVSSLTSVFSHASGSGEGSGGGERDSPSPPYPAPSPSSSHNSLHLHPAKQLGSNYTAPSSPAPSHSARRASHAKIHFAPLPVVPPELRRRNSISLGVASRRNLIGMQGPKGGVQSVVMNDEDWENYCKQFEEKHGNNDVIDVGQLAKSGAKALWRSVKRRRSGSQSSQNSTTSTATTASTSASPSVVSDSALLGRHSLTGTPNSGSTHSLNGSLHLAPVREETEFALKSIPGSPPMTTIDDHGLPPMRVRAPVPRRPHSPRHVRAAQAMLHNSAMDMEMRMGDGDAAAAATAGDGDGDATPRRRPSPPPRLADTLPTEDELEQIADEKEEKEAQDAPAAPEDEEGEEEEEEMAEDSLSSVAEGALGPEAGAAAAAEMVAPSSPEEQASIESHDIESREAHDDRKRGRRSAVLGFDVERFGFMSIDDDKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQF4</accession>
    <name>A0ABR3BQF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613231.1">
        <property type="nucleotide sequence ID" value="XM_066758783.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991161"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="3">
        <location>
            <begin position="82"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="309" mass="34016" checksum="39FD54E9BED1C55A" modified="2025-10-08" version="1">MSLTTSAIIHPLAISSRTTSPFLRAVNSNVTRTFASSSRQQLVASSRTFIGFRRTSVSELRRKTSPLYFTPIIRQQCRTMFIQTETTPNEASLKFIPGVQVTNGAAHEFLDLRTALQSPLATRLLTIDGITGVFFGPDFVTCSKDDSYSWSILKPEVFAVLMEHFSSGASLFKEGSGESQAEDTRILDTDSEIVGMIKELLETRVRPAIMEDGGDIEYRGFDEVTGIVKLKLKGSCRGCSSSSVTLKNGIERMLTHYVPEVQSVEQVLDEEELIALDEFAKLEARLEKEQGGDKAGKSGKGDMSSYLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQK6</accession>
    <name>A0ABR3BQK6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613276.1">
        <property type="nucleotide sequence ID" value="XM_066758828.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991207"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="196" mass="22173" checksum="3DA6309CA52E5B6A" modified="2025-10-08" version="1">MSFLFRSTLRASTSRLPTVLPTPASRPLAFLPLPLSRFNSSLSTPPSSSAAKPSSPPQNPINPRFAELTSSLSIPVSSTSKPHAAAAADPTSEDWWMTVSKKSNYNTFSSTKNFHPTKYFSGRSVELNRGTDFLVAYKRMQGVMRMGNMKKEAKLNEFHEKPSVRRRRLRSERHRRRFKEMVRTKVQQAVAMRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQN0</accession>
    <name>A0ABR3BQN0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613459.1">
        <property type="nucleotide sequence ID" value="XM_066758057.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990419"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="68" mass="7699" checksum="F80C4BB209A4A02C" modified="2025-10-08" version="1">MTRVAIPEAGRIETPLRDEEGGFGGRRDDFEAVEEMETTEPSHPNRQLWRPPSFDPDTSKVSGQKNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR41</accession>
    <name>A0ABR3BR41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anti-proliferative protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613624.1">
        <property type="nucleotide sequence ID" value="XM_066758222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990596"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF22">
        <property type="entry name" value="BTG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="3">
        <location>
            <begin position="50"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="533" mass="56747" checksum="084D48720EA52350" modified="2025-10-08" version="1">MPSDSDPSPALTHASLTSSHSLQSENFQVHLASHLSYDRSLTTALSHLVDHLIGPLSTLYTPEILNSLLKQLKQALFVKFQPTWDESHPQVGSGTRSLICTKHYGLPFPMRCAAVTVGVEEKAWRKAIAKSGGRENRSDKGEEWEVWCDPGQVVWRWGAWEWEDPGFEPVKTVREPLQVIWQAATEAEKLSPATPVKSAQPSYPTPNRPSYAIPIRAPIVLAIPPTPSEGENRQNESKPIERGSLLPAFSSLGLGQAPGQAQRSQQASGWSSSDASSRSTSLTFSEHDEPGSPGHERPASRGSHRGSESQSSVSSSVSDSNSGHTQLLTPDTRPTTADPFNVPILPMDTVKHSKEKEEKPKTAPTNTARGRTTSPSALGESTVQSTTPTAENNITPRVPTPTVTPYDGGNVTVLGGGVKLGGGGSHSRTSSAHSSQRIPIDRSRSPSISLASRALNTAVGPSGEGRKQRTRRRIMPTYLGHLGQPGVGGPAMGVFYGGNVSPGGMGFGPGYQHVGVGVSPPPVGIRGPMPRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR65</accession>
    <name>A0ABR3BR65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103758</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613641.1">
        <property type="nucleotide sequence ID" value="XM_066758239.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990614"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="11">
        <location>
            <begin position="93"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0247680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="321" mass="35637" checksum="E84926B96C7C353B" modified="2025-10-08" version="1">MQLATRDPYVYTPSKTETNNKIITKREALAVAPNKRKSHANKIICFKTRNFLIACIALVTTGLYWFSSVPSRSQLPSTLLQDTMPSSLKHLKISPKEAHTATVIFLHGLGDSGHGWLPVAKMLWSSFPNVKWILPHAPIVPVSLNQGMAMPSWFDIRHLDKLDNPEHDDEQGMLETVKSVDELIQAEVDSGIPEDRIVLGGFSQGGAISLLSALTTKRKLAGVVGLSCWVPLSHKIAQMKSEHAKDIPIFWGHGTNDPVVDYSFGQRSIDFLVQKCGYRVLPQGTTFARPGIRFESYPGMPHSSCPQEIDDLKSWLTEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR79</accession>
    <name>A0ABR3BR79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-binding cassette transporter YOR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104408</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613333.1">
        <property type="nucleotide sequence ID" value="XM_066758885.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991264"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="917"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="955"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="225"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="630"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="922"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1234"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="573"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0247372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1491" mass="164655" checksum="8C252D9BEBE588FF" modified="2025-10-08" version="1">MSPLLPTHWGTSAHQNEPTLPSSSHSVSARAGDEEKLRSSEGSEEGGDKRQVMVVFEQKSGKELEKPIEEGPFTQPRWRHSLPFVKPKHPPPPPPLSLDDAPVTPEVSANFFNLLFFNWISPMMALGSARPLQDTDLWKMDAARGAKPLSEKLLASYAARTKKANEYNARLADPSTPLPLSRRILYSVLPHRERREKDYREKYGKKHASLARSLLDVFGWFYMSAGFIKVFGDTCQAVTPLVIRRLITWSADYQAAKSAGLELPSRGPGIGAAVGLLLLLICSSLGMHHYFIRSMGTGVLSRAAIISAVYQQALQFTQKSRGQIPNGKLVNHISTDTSRIDFAAGFAHMLWTAPVQMVVIIIILLVQIGYSALPGIAFLLIMTPLQARFMKTLFMFRKKAATWTDKRAKLLQEILSGMRIVKYMAWENPFLERIHAIRGMELKYIRLLLTFRSGMTAIAMSLPILAAILSFITYSLTSHSLQAAKIFTVITLFNLMRMPLMMWPMTLSTTADALNALGRLEAVFDAELVKEHKKVDPSMDVAIKLENASFTWDSAPIEQDNTMAKLTGKYAKALNGGKPTGPPGKKEKKKKSKKVTVAEEVQAETAAGQPGAGEASAEGQGQKNPSAPGIDEGNSEKKEKEIFQLRDINLNIAKGSLTAIVGAIGSGKSSLLQGLMGEMRRTTGSVTFSGSTSLCAQTPWIQNATVRENILFGQPWDEERYWAAIRDSSLEADLELLEDGDGTEIGEKGINLSGGQKQRVNIARAVYYNAEIIALDDPLSALDAGVGKAVFFNAIISALSGKTRVLVTHALHLLPYVDNIIMMEDGKISEVGTYQGLKERNGAFAKLIKEFGNEELVEEKMETEQEAVESSGSTITHDRSNMMSKGNARTLMQIEERNVGALKKGTFFDYLKAGNGVFMVPVLLFCIAVAQSFYVITSFWLVWWEETKWPQPSGFYMGIYAGLGVGLAITLFFQGFANAMINYFASVNIHHNAISRVMLAPQAFFDTTPLGRIMNRFSKDTDTIDNTLSDAMRMAISTMANIVGSVILLAIIEPYFLIAMGVVSLLYLHNAIFYRRSSREFKRIDSILRSSLYSHFSESLSGVATIRSYGEIERFFEDNIHRVDIENRAYYLTIVNQRWLGLRLDFLGSLLSFSVAIIVVCSSSVSASNGGLGLSTIVSVQQAFSWLVRQIAEVENDMVGAERIMHYANELEQEFPHQIEGTKPPASWPSEGSIEFKDVRMRYRPELPDVLKGLTLNVGGSEKIGVVGRTGAGKSSIMVALFRMSELSNGFIKIDGVDVSKIGLNDLRSGISIIPQDPLLFSGTLRSNIDPFNTKTDAELYDTLRRSHLIGSSDSSQNSDSQNRFNLDTVIEEEGGNLSVGERSLVSLARALVKNTKILVLDEATASVDLETDAKIQETIRQEFRDRTLLCIAHRLQTILAYDRILVMSDGQVAELDTPENLFLSDGIFTEMCSKASITLTDIKAAAALRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRJ5</accession>
    <name>A0ABR3BRJ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613239.1">
        <property type="nucleotide sequence ID" value="XM_066758791.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991170"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="866" mass="94800" checksum="6940D42B1A55B427" modified="2025-10-08" version="1">MSVFTPPALLYHPPHRGPYYAHIALQISIHHARVDDKRQAPTTFTYGGGSTIQRETSRQRTKISRVGFQGIYTKRSGTLSSASSSKMASRVISGTVSSNSHSQFSHPSPPLNSPSFLADDQQVLITDRPMRKSTSSSPPVAGESFWRWSHKASVTSSDFSPPPSTIDTYAPTELHFAASHFSKDGERRPMEAKSTHYSESSAGSIIPDVNDLAISPTIFKRGQAPQPVVQNQVADGGLTSIPEASSSANSQGQQGIAHSQSCPTPLLDILEKNHKRSSAGTFGPKNGKYPSIYSITSSNTPPERHIASNIFDTPPAANQSTHRPSSYSSTSTSPQQSAIPKTVDDTAAVAMRRGMGMTSLCDRAGHRNPESECQIEDYLRTQSEGNRRRIAPASSTVSALDFVFEPAKNLYDDLEDKMKMKKKNFRKSKVDQMLGEGAEHVRMTMEMNRTTLQKALAGTVKQTNGPVPPPRNHKHFPSAPTNSLHTFSPTKSTNSVRQEFTYAEALISPATTNFPASHSHKLPLGRSASIDSLPSLHPSLAESVNLERRPLLKHSLPPLLTRHHPSRSTISISHPSLPPSFPATNPALSMSSSLTPSQRTILIRRTRKLEALLGEPLPESQISQHVIDPLNSVKQFDTHVKEGWPDSPPAGWRRRVPEWEREDCLVRRVKVENDEEGGGEVKGNRSLAQKALEALNLAGKRPEGEHLKVYVSRQMSVTETVTQGNVGMKTSVNRAELRTDTVSPTSANSTGADSQWPAGNEGDEGKKIRRQQLTKLHRLLGVPVPAEFINPASHQKTDPHAWHTPDKRRVSVPISPEITLSRAGSPSEQSFMTFDEPSSGNRWSRLKSLHKRMGTGGGMAVYRGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRT0</accession>
    <name>A0ABR3BRT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613851.1">
        <property type="nucleotide sequence ID" value="XM_066758449.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990824"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="249" mass="29669" checksum="B6F7AB6D16700A24" modified="2025-10-08" version="1">MDDKQINDHYRFFNLPSREENGKSGISMQAPKLVRCRRPQAHLPLNLLSGQLSPLLPYPDRTEYHFMRFMLEDGTTLERKEYCKAWAVTKQAVIFFEGIQESLRAWENPAEPKYEDEMLRASAMLKKWKAYLAELTFSMHTLRIWEIEHRVPEKWAAIPDYDYDNPHIFPLKTINSAGEKETRILTPLFIPLSKHVIKLHEEGFDEEWFDLWDRLKPDPEKFAPYHLPLERPWPYKDIALRKKTGEIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS78</accession>
    <name>A0ABR3BS78_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613964.1">
        <property type="nucleotide sequence ID" value="XM_066757580.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989935"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF1">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="48"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="198" mass="22841" checksum="F077EF9F14788B02" modified="2025-10-08" version="1">MSSVATSVIESPASGASGVITTFGQRKDDTMVKKNSREDKEWNRLAVHMDSYHNSFRLEFKRVYTLADGGYEEQAMKLPRFLRLAQQLSSHLSMHHRIETYIFPILSKKMPQFAAGKRESGEHLVAHQKIHDGLDRYDRFLSDSLDDPSVYSGQKLREIMDSFREVLFTHLDEEVKDLQGESMRAAGWTLEEMKRIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSH1</accession>
    <name>A0ABR3BSH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucan 1,3-beta-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614093.1">
        <property type="nucleotide sequence ID" value="XM_066757709.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990065"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047290223" description="Glucan 1,3-beta-glucosidase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0249906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48514" checksum="785B28A7095FCFEA" modified="2025-10-08" version="1">MRLLSPFFIVPLAVVSALPALQTVDDQKRSVNVGWPYGTNKIRGVNIGGWLVTEPFITPSLFEATGNNDIVDEWTFCQYQDYNTAQAALKNHWDTWFTEDDFARIAAAGLNHVRIPIGFWAYDVQGGEPYIQGQADYLDRAIGWARNHNLAVIIDLHGAPGSQNGYDNSGRRGNADWATDNTNVERTKNVIAQLSQKYSDPQYYGVVTALALLNEPATYLNDQLLQTARQYWYDAYGAARYPFGNSDKSGLALVIHDGFQPLSTFDNYMVEPEFEDVLLDTHNYQVFNDEYVAWNWDQHISNVCNQASTYSSSPLWLVVGEWSLASTDCAKYLNGRGINARYDGSYPGSSYIGSCDGKSNDVSKFSNEYKDFMHKFWNVQTQLYEQNGQGWIHWTWKTESAADWSYEAGLDGGWIPWDAGSHDVSLSSLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSH8</accession>
    <name>A0ABR3BSH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614069.1">
        <property type="nucleotide sequence ID" value="XM_066757685.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990041"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="562" mass="56265" checksum="5E0B529ECE17FBCD" modified="2025-10-08" version="1">MNAALLQQIQQGKGLKKTQVNDRSAPQVAGSVAGAGGAAGAASASSNAAPRPPAPVPSGNDPASQLAGLFAGGMPTLRKTGDRAASATGNLAKPPPIPSASRAPSKPSKPSAPPAPPPVPPPAPPGRTAPAPPPPPAAPPAPPAPPAPSSRAPPRVPPPPPIPPAPSRTAPPAPPAPPPPAPTPARNAHRKEPPAPPPLPGRSPAPSLPSRPASSVPARAVPPPPPRPSSTASGRTPPPPPPPPPPRPTGPPTLPSRPASSYAAPHRALPPATLSRTDSSNLAPPTPPRRPSSVSMSASPTPPAPPAPPAPPAPPAPPAPPAPAPAAPRMMPPSAPAPAPSRPIPPPAPRVIEPEPEPEPAQYYEQEEEEAAPPPLPAGRHISRLPPAPPSAPPPPPPGPSPAARAPPPPPAPVPARAPPSPVPSPTPVSERTRPHPAGTTFAPPPPPPGISPAAAANNRSSLAPPILASRARSHSQSQSHSQSHSQSQNASHQRSYSSNLTSDGNDANNDDEDYQEQVPEPPAVVGSWTFPMKGMFPAPRPWSGRKKTYVSGNMQGGGIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSK8</accession>
    <name>A0ABR3BSK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_103250</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614134.1">
        <property type="nucleotide sequence ID" value="XM_066757750.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990106"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057091">
        <property type="entry name" value="NDC80_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24487">
        <property type="entry name" value="NDC80_loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="13">
        <location>
            <begin position="108"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Kinetochore protein NDC80 loop region" evidence="14">
        <location>
            <begin position="432"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="293"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="388"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0249947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="671" mass="74963" checksum="ADBC2661CC366A95" modified="2025-10-08" version="1">MDFRRQTLASNGGSSHPQPLVPSSAVKKVGRLGPARQSLAPSQIQSRTSILGVSNSQENAPHGMMGSKKSTMPGKMGDRDQLMSASRGDGGMYGRTPQMNRGIPGSVRRSSVFTSNSQGRTSMAPGVYSTAYKDPRPLRDKVFQSNCMRKVNEYLISVRYPLPLTAKTLTSPTAKEFQSIFKFLVNDLVDPGAAWGKKFEDDTLSILKDLKYPGMDSVSKTALTAPGAPQSWPNMLAMLNWLVDLCKALDNWDDPEVISDPLMIPATELPLDYPNLDDRLLWDFAAKTYSQWFDGEAEEFEEAEQELEHAYDRMASATVAECEKLEREIQKRDVEIQQLHAQEPPLKKLEDEYVQLMSDKNKFISFLDQQGQKMEKIRLRISKVKEAVISQEAELEARQSELARIEQAVAAQNLTPDEVQRMNHERDSLTRSLEDLRNKISEASQFAYDQEMVVTKSMDRFEGLLTDYNSLAHQIGLLDSSLDAPSLAADVNYNLDVDLGAEELEEVKAVGVRMRSIIWQALQTCRETFRQEALGLGNGTIALEDEFDKLGQSVERQKEEVGNLEVRLKIVHNQAEDAQSQIASENSDTNKIITQLETEVTNMLAASQQGVLSTQSQLESTRIAFKELRHKTALFQDSVVAEVGEHIDAIIKAKEHTANSLKSIRALAETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSQ3</accession>
    <name>A0ABR3BSQ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614181.1">
        <property type="nucleotide sequence ID" value="XM_066757797.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990153"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0249994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="546" mass="61008" checksum="A2CE4C3ABBEAE245" modified="2025-10-08" version="1">MAQKYPARAHALKLIHELVKLIPDHERGKLHGIFLQGSPTLFRDDTDHEHPFHQEANFNYLSGIIHPKCSLAVFFSLPSTPSSSSVIEHHLFIPAADPAETMWSVAPPTLEVAKQVYDSDNITFSDNMPGVLVSAVKSGNGEVVLHVLPRTMEYPALPEVIDQIPGLRLEWSYLFEALHIARLTKDEYEIDLIRQANRISSAAHEVVMRELGRFASTREKGGRDLKERTGKEALREWEIESERDAEAVFVATCKRMGATDQAYMPIVASGTRSSTLHYVCNDRLFPSLPRKQGDVSFTHEVSRGCCGSHHNQPISSLLHNDAFLPQLLLIDAGCEWKGYASDITRTMPIGNGGKFTKEGGEIYELVLRMQKECEELVKPGVHWDTIHLHAHKVLIDGLLSLGIFTGSPEDILQSGITAAFFPHGLGHSIGLDTHDSLQYLRLVHKDFPPTTSSTPSKLYKYLRIRLPLTLNMVLTVEPGCYFAPQLMEEHGVWSSEFVVKDKLKEYVGIGGVRVEDVIVVREQGVENLTTVGREREWVEAVCSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSQ9</accession>
    <name>A0ABR3BSQ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S acidic ribosomal protein P2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613674.1">
        <property type="nucleotide sequence ID" value="XM_066758272.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990647"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="111" mass="11088" checksum="FDDF15F7DC937C50" modified="2025-10-08" version="1">MKLIAAYLLLQQGGNASPSAADIKALLETVGVEAEEDRLSKLISELEGKDINELIAEGSSKLASVPSGGAAPAAAAGGAAAGGAAEAAPAEEKKEEAKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BST7</accession>
    <name>A0ABR3BST7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UMP pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103317</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614201.1">
        <property type="nucleotide sequence ID" value="XM_066757817.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990173"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="UPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0250014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="213" mass="23231" checksum="DE8CC9E9B0999EBF" modified="2025-10-08" version="1">MSKINISNHPLILSKLTQLRLHDLPPKDFREGVRAIGSMLIYEAARDLPLRDVLDLRSPIAPFTGQTIPLRIGLSPILRAGIALTDAALESFPEATVLHLGLFRDKVSLQAIEYYSKLPSQVTADLVFLLDPLIATGGTAIAALNMLTEWGLEQSQIRIVSVLGSKSGVKNVQDEFPNVEIYIAAIDDELTDKGYISPGLGDAGDRLFNTFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSZ7</accession>
    <name>A0ABR3BSZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614261.1">
        <property type="nucleotide sequence ID" value="XM_066757877.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990235"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="382"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="959" mass="104134" checksum="8BE6C1D198F71811" modified="2025-10-08" version="1">MSGTERFSSQRHHLGFQALRSLHCDFLRDSIRYHGLHGASTGINTPPRFPHKGAADLAQGAQFHQSRRFRLKYGFHSSAYNPSSVLLQLLFPSAHRPERPSTSPRRTALICHFKTSRRLAATIRKFSTAINIWTAARWPKDLGSPSRNGNGAPSFKGQADSSSLAISFDPNFQPPKRDSPTRNPLSASTRPGASRRNSGSGHARGGEGTTGSLQIPLSTSASTSELPSGPSSLSNVRPSAAMIRKKSGEIVKPSLKPRSLSTPDLMRQGQNSPTGASPNSFGTERSKSVRFADTSQGDAKALESVVLFLREQKVTAVGKAADPDNAQLTETETENDTDASDFVQFRTRKNAAARAADEANQIQLSGASRVPRKRTDFSPDARGSLIGENVILERVELQSGAGLTLRGSVIVRNVAFRKWVAVRFTLDQWQTVSEIAGTHVCHIPASTTGDEGWDRFSFSIKLEDYKRKIDERQLVLCVHYSIENSDWWDSNNGLNYAFTFKKSPPRRPFRSSGPASLGSNYFGDDDFASPLPGLRKGNTPPPSSQIKKVFGSKDSKASSGSSHWAFPRLFPHFNHVDAPPRPDSPAQSPPPNSAYEPPAPPTVHTHLSLSKYCAPSPPQSPSKELPAQSPIAHETHHIPQQSSMDVMAGNYATISPALQLHPYERRSSWNGHASSWDSSRANDKPAGGRPDGDKTPMALASHSPIISPDVPSPDVSPQKPLTLKRSTGNLRKLVEDAEDENGLITPPSSKGSSPPTPVHASLPPDLVYTSPTSTGDTSSVNTLSTESTPDVASLSIDTEPQVGDRGRTGHPNDHRFFSANSYQEFLDKFCFFQSPRMTPNELEPISRPSHIPISGNNSPNGFPFFSHTNASRSPRSTPTPTRHYNSAQEAFGFTAPSQDVTPTKPESLMPHMAHPHPQPVQDSSVSQIISGYHANPTDTMVWAQQIHSDSVSPSLAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTC0</accession>
    <name>A0ABR3BTC0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613233.1">
        <property type="nucleotide sequence ID" value="XM_066758785.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991163"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="638" mass="68374" checksum="AF5F076E60BD2AD5" modified="2025-10-08" version="1">MFWRKRTATPLPNYLPPASAEPPKPILKKTAESQEASNLRFAGGTKQLSGGVSSPNTQLPPHLPQTHSENDETRRVRPAPLVIVSSYDGPQLPASPGSQGSYSPGTASSSHVRVPSLRRSSRPTSPSTSSFGARIRANNNGQQRRPSAPCHTVMSTPPSSAPVTDGGIWTPPGRFSPASHVISTPPSPYRSTSEHTAQLEIRPFNERLPLLSEGGPPVHDVESEQDVDVPMLNIIPATPQDQGDGFPVKTGVKALEAAAPIEQSIREIEREMMDFPLDDELLEQTIWEKERVPTIDLDFNFTSLESLMDFSISQDLIAAIQKSSTAVDEHGQYESPDEPPSPFLHDQPPSQPLPPSPPHQTFSSLPSFDSHINSASPLPQSSSNSSLASFPDVEEALGSMLASLSERSVASTAIHTPKNRNFEFVSEVCSGFDDMMIGVGGRTAPLSISSCNKSNPRIARQAPSKLDLSSSKYGHIAPQELQSAPLASRRNAYFPNARVHPKSSPSGIFTTVSPSSSQSSVSSGSRYASHPTPMAGFSNFPSSASESELGHMKDGRHIQNYRDSLSGSEISDEELCTASIISVTPVMVQEKMGIKIGEGGDVTKELVFGKHFLKEKAGLGFGLGLGLEVEGNEVGLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTE8</accession>
    <name>A0ABR3BTE8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103384</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614266.1">
        <property type="nucleotide sequence ID" value="XM_066757882.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990240"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="212"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="507"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="785"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="785"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="865" mass="94439" checksum="1925CD7B6B9F9C21" modified="2025-10-08" version="1">MTGFGTPSVAAAATPTVISTFFSHVLAHRRRKNASKKSLQAGGPGGGPEDQLTYEEGLHVVKRFLEFASHHGVEEVQAFTAMWVPTPRWVKRDVMTIPDENIKEAEIILAKHLSAYGPQGAEGGGLQLVGGDKWWKVRRRTLEGEWIEMQQDYLKRTAKKAAAEYSAAADLTSPASVTASGRSNVRYMPHKRATVGSVVDNAGGEVLDDRVIMYIHGGAFFFSSLETHRYQVQRHARKAGARAFCPAYRLSPQYPFPCGLLDCLAAYLYLISPPPSAPHQPILPTNIVLSGDSAGAGMVISLLVLIREMGLPMPAGASLISPWVDLTHSMPSIGGWDGGDFIPSSGFHYKPSCAWPPLPGDGIDVTMPDGSVNRYDEQIQMYCPNNLLTHPLVSPVNQGSLGGLCPLLILGGGGELLRDEITYTAFKAADPVKYPPSSITLSQYPDQASKIAKYKPTKVHLQIYEGGCHVVPTLSWTKSAKYMYRACANFNIWAFTAAHKALEKKLQQKTSHSSLRKQRSAPSLKHLNNLNKLPDGLPPPSTSDSLANGAVLSSLSPACPGVNSAETPSPVSTSRPTSRQSTIDFTQPIITSGAAVAANTKPISFREVQSEAESDEDYMSVTTESTVEEEERGDAVPAKGIVTVHGTEPLYGNVNLVSERVSVHGNIRPFEPVEAVPALQPSLREHIGQVHGDGAIRKWLARRHEWDKKYSKDLAKWRDIKQKDRIKAEAEGFLTRDLQGERPPLCSVAGIWEAKLARDVARSVDEVTSRSMGLGWWTKWGSKADEEHADRRKMRENAAREEEQNKLRLPNHQGIPDAIPPGPMATSDPPTGETGGARQLFDEPDAILFEEAEGERNGVETARRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTN5</accession>
    <name>A0ABR3BTN5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614203.1">
        <property type="nucleotide sequence ID" value="XM_066757819.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990175"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046263067" evidence="2">
        <location>
            <begin position="25"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="187" mass="20281" checksum="616F1A43C837B48C" modified="2025-10-08" version="1">MDPWSISIDTLFLILTLLLIPSISRTPQLNVTPPDDLLISPPAIPLSPITPASPSSSHLSVPGVDMSSMIPGITFTPDAPEIYPRHRRSSFGSLTKRFGHKRKSVNFSLSAIDDVLPSQASPNKRRPPTPFVKRPKSPSPSLSSANSQPGTPIPMVAGVTGEVMAEDMKHRKDVEDAMGVKKKWLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTY6</accession>
    <name>A0ABR3BTY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614320.1">
        <property type="nucleotide sequence ID" value="XM_066757936.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990297"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF10">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="142"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="363" mass="39710" checksum="17404A944E2532F3" modified="2025-10-08" version="1">MPIAITPDTKLKLAVIGLGRIGAVRARILSRYAPKIHVVAACDSKPGSDVWAAENLPSHVQFFSDPEELFQKSGAQAVLISTATATHAPLVLRALELGYHVMCEKPIAVDIATTKQVVEAARAKPELKFLVPFCRRFDESNRALKKLVDAGELGDIHAVESWCLDAQDPTGFFVQFSPMSGGIFVDMGVHDIDIARYFLNVKKGLTNPKKQVNRVIAFGQTAVYHDLQQFGDADNGYGIVEFANGKILTSHIGRTLTNGHESSTRVFGTKGTAVVNAESPVNRVQLRDAHGVRSETTGDAFVLYQQSFINDLDEFATCILEDKPLSLQPEDALEASKIATALQYSFRNRVPVEFDDEGEPIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUP1</accession>
    <name>A0ABR3BUP1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614349.1">
        <property type="nucleotide sequence ID" value="XM_066757965.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990326"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="503" mass="53916" checksum="7AD9FAA6C4846F65" modified="2025-10-08" version="1">MRTPYSKTKVKAAVDKWMPKEETAEGQEEEEDGVRVASSKASGMSAGSMQPSTSLVKSKTTTSSLRRGIRRPNYVIQVGCSHIAGSGSTSVPLTIEIKAFPLSDSGHPQSELEADKAFVRGLSQTAMYALAGWEMFRYRRGLFICGPTFSRVFVLDDNALAVEVASPPASLTALSVSSFFSSYNYDSMPHSLIFPLVNERGVSSPLLRYGPRYTINPLSCRLLERVIRGVVERTLGQTVGEALGCQTEEMNFDSLSASYPGIALGILIPSYIPLDLVEVARHSATISKAANSGAGRKKKVSSRKSPYLEARGNRKDRGGGGGGSGRSGRDGRDGRDGRSGRSDRSGKRRQNRVGSGGDASEKRGGDGGTGSGACDEGDEDTGIERSHNLSADNDRDRFIDAPRASLEAEGVGWKGSGCLTKADRCNRLNDWLEALPQAEKPIDIPSNGVSPSNPAVDDVLAHLTMDSIEYQELRIANVLGDLGVHFVSVSSAQMDELFSPILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUW2</accession>
    <name>A0ABR3BUW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 13">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_102902</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 13"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614906.1">
        <property type="nucleotide sequence ID" value="XM_066757437.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989758"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="NUDIX_DNA_Glycosylase_C-MutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="137"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0250719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="572" mass="63585" checksum="1EEE566E09CEC05B" modified="2025-10-08" version="1">MLPKSSSPSVYSVSDSDSSDYAPSVSETKRSSFKRKRAAPVSTKSRTKATMVKGARGKSIAIDNLEDIEDLGITISRRHGMEYHSVDKIVDGKESLLSWFERVREKRGMPWRKEYDPSLSIEEKGQRAYEIWVSEVMLQQTQVTTVIAYWQKWMERWPTIGDLAKADVEEVNAVWRGLGYYRRARSLLAGAKTVMGNSKYDGRLPDDPVTLQKEIDGVGRYTAGAICSMAYGARTPIIDGNIHRLLTRLLAVHAPQTAPATIKFLWWIADELINHLPSGDKHKGVAGDWNQALMELGSQICKPANPECGICPLQKFCKGYAELSNPPPLPSTAESDCKLCAPIPCDIETNKIPTVMMFPMKKEKKASRVEEESVCVVQWRGNGDQRRWLFIKRPEKGLLAGLFEPPTTPVSAGLSHSERLSASLEALSDYIKITEEDAEGLQTSNRDVGNIPHIFSHINMTYHIHLLTLTTSGSEPPSIKPRTPRPAVWLSGEEVETANVGTGVKKVWAEIYGSWGSFEESKMGAVVGKKEKITNNKSMKLKSPAANKDGKIVKKVMMPAMPTRKKVVDVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV09</accession>
    <name>A0ABR3BV09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_102989</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614960.1">
        <property type="nucleotide sequence ID" value="XM_066757491.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989845"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0250773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="464" mass="50660" checksum="FCDA5182F5572338" modified="2025-10-08" version="1">MTAELTPSIENQALTSPGPFEGPEKLLEVWFAPSVEELPSAEEVEGKIAGGLKTRPAKGNGGWQGLRKVPREVWEEMLDIVKCKVLSMVEGDDLDAYLLSESSLFVAPHVLILKTCGTTLNLLGLYRIIEIAREYCGFSNVWRCFYSRKSFFFPERQQGPHKDWRDEVQFLDSVFGTAGAAYTVGPMNRDHWLLYLTTPNSQPILPSDPKPSTLSLPATSPSSSISAPEFSSSSTITYQDTTLEILMTHLSPTARAPFFHDSDSFASPSTTPGHVLGEAISRKLGIDQLFSKEETTLDSFGFDPCGYSANAVIGSGLPVSGKDGKEGGGYFTIHVTPEEGWSYASFECNVPLPSSSSSSSSSGALAKRPDLQTLIRNVVNIFQPSRLSITLFVSTPPSSSSPGSSEAEVKAWNSFGTDLLGDEFVRKDRIGYEFDGYDLVFACFEKKGWVEPKLEFGSEAKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV89</accession>
    <name>A0ABR3BV89_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101699</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615030.1">
        <property type="nucleotide sequence ID" value="XM_066756253.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988557"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="9">
        <location>
            <begin position="211"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="292" mass="32285" checksum="4838C279CA4FF4EE" modified="2025-10-08" version="1">MWSSMPRTLTRLPTLRSISLTSHRPPTLPFPRPSASPISRALHTSRRSHTKYERFDQRPSFGGSPGPSGDGPTIWQYIKRRMGGDRAVWVYGIGIGGGGIYYVTHLERVPETGRLRFIDVDEAQERELGRQTQLQTLSEYDRALLPPNHPISKRIRKVATRIIESSGLGRVKSSGEMGAIEGTVPTWGGGIDMKDVFFGGGEGVKEVREGKDTEWEVYVIDDKKTKNAFVLPGGKIFVFTGILPISGNDDGLATVLGHEIAHQVARHPAERMSSMKSSTPNFYAAIAELEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVH7</accession>
    <name>A0ABR3BVH7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615124.1">
        <property type="nucleotide sequence ID" value="XM_066756347.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988653"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="TerB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="584"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="963"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1097"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="967"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1035"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1105"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1122" mass="122822" checksum="D176BA7543971459" modified="2025-10-08" version="1">MIPSPRRVASTPAIQTWPDLDDDDGWQDMPVIRSDSNPFGLDEEDQKKYHYRAPVLLDDDLAGPSGTGNATGKHLELEADTLATDSWREKEEQDESDYTRIRLDEDEESEEVHMRTKYLFNEDKAMTPLSQMQTTKELLTEGQRIAYVALCHLIMKRMVRDMGRGWEGYKAKNKLGIKGKGKVEVPVVESGHIWMLKLMARLYQHMELSKDEQHMIESLAEHGVDPSDLVPALMTTHTVNNPDFDPKEKERVDLEEALRKEAEADDEAEREAKAEEERRVVIEDQGTSDTETEPPPPYDVHERSISSATSSMEKMALSPSFELPSKSVNPFGFDDDVPKPLLRTKSPSAASFPTDSSTILSSRSNVNPFGSDDEDEGPLSVSETPEAQSKAQTLSSLEEDEGDIGSARSPPLPDPSNPSNSPLGAASGSSADQLAPCRPQSLQTEDPSQSTPDATDEPSVDTKQTPRGEPVALFDAADPRAPAPLPALPGVSTSLSTTDEHVTLDIRWTVLCDLFLVLIADSVFDARSRAFLVRVAAALGFDWLDVVRFENRVTEALEIQEGMEKKGQQEIIEGRRKAARNKRYAMMGLAAVGGGLVIGLSAGLMAPFIGAGLGTAFATVGITGTTGFLAGAGGAAVITTGGVLTGANIAGKGMARRTREVRIFELKPLHNDKRVNCYITMGGFMASKVDDVRLPFSVLDPVVGDVFSVLWEPEMMAEMGNALKILTSEILTQVGQQVLQATVMTALMSALQWPLILTKLGYLIDNPWSNALDRARAAGLVLADVIIQRHAGVRPISLIGFSLGARAIFYALIELARQKAYGLVQDVFIFGTTVTASRDTWLDVRSVVAGRFVNGYATNDWMLGYLFRATSGGLNTVAGLRPVETVSGLENVDVTEIITGHMSYRSCMPQLLAKAGFPVTADYFDEPDDPEIDMNVQERIVVDEAEEEAKRNRKKVLGIFPVKVPRSSGSGHNTPSAEKHSGTSTPNPYVSQAAAGEYELEDDELPPREEVDIGQLPSEKDTSMPVKTEEEEELEAKLVKQREEDEQKEREAVQAIPKTAGFDFQAISRELGKNIDVDKLKEPEPRHFPPAFIELRTPLERSGSAPPPTSFVPPPAEENVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVN2</accession>
    <name>A0ABR3BVN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynamin GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615163.1">
        <property type="nucleotide sequence ID" value="XM_066756386.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988693"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="6">
        <location>
            <begin position="25"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="5">
        <location>
            <begin position="741"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="546"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="832" mass="90878" checksum="A601E52917373B91" modified="2025-10-08" version="1">MSMDGDLIALVNKLQDTFNAIGGDAVDLPQIVVVGSQSSGKSSVLETIVGRDFLPRGSGIVTRRPLILQLIHTPPHSSPRTPINNDDDYLPNLDETPTAGAGVMRPGGRSMGDGTGAEYAEFLHINRRFTDFEEIRKEIEAETFRVAGQNKGVSKLPINLKIYGPGVLNLTLVDLPGLTKVPVGDQPTDIERQIKNLVLDYISKPNAVILAVSPANVDLANSDALKLARSVDPRGLRTLGVLTKLDLMDAGTNALDILTGRTYPLKLGFVGVVNRSQQDINEDLPMEDARSKEEEFFRTHPVYRNIAHRCGTKYLAKTLNHVLMNHIREKLPDMKARLNTLMGQTQQELNAFGDATFLGEQHRGSLILKLMTEFSKDFVSSIEGTSLEISTKELSGGARVYYIFNEVFGHALQGIDPSQNLSLADIRTAIRNSTGPRPSLFVPEVAFDLLVKPQIKLLEAPSLRCVELVYEELMKICHNCTSPELQRFPRLLTQLVEVVSDLLRERLGPTSDYVSSLISIQAAYINTNHPDFVAGSAAIARAGAPSTTQISKLQEPASEVDDEESEGESEASAPNGYVTHPRSASASVPDIRRPTTALGGKETKSRKHIRTASGSHTGPVSGAKQGANALLGAASAHNMAGTSPHTAKESFLNYFFGGPNGAGDDIGSVQRALGKSNTIQHHTQGQYQPQQREKDLLPDLGGRRGGRLENSASFDMKSLGKHLEATTGDQLQLTPREEMETTLIRSLIASYFGITRQTIQDLVPKAIMHLLVNFSRDAIQQRLVTQLYKPELFADLLFEDEALVSERTRVKALLDAYKEAFKVLSEVSLKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVP4</accession>
    <name>A0ABR3BVP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="1">FBP aldolase</shortName>
            <ecNumber evidence="1">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615182.1">
        <property type="nucleotide sequence ID" value="XM_066756405.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988712"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="293" mass="31482" checksum="C6EC5DDC68CE63A0" modified="2025-10-08" version="1">MSLQNNFTLDILKKAEEGGYGIVAQTCYDANMAVALVRAAERNKSPAILQLFPVTLAAGGGPLLQYCLDVAHNASVPISVHLDHATDPEHLELSIGLAEKGIKFDSIMVDASHADTDEENIAIAVPYIKRCRAAGVATEVELGRLEGGEAGLREITGAMLTDPANAEEFMKATGADILAPSYGNLHGSYKFIGGPKYKLEILRDLQQRFRGRTPYLCAHGTDELPDSLFQDLVKAGVSKFNINSWARDPYVETLGKELSAGTPFPDASEKAIEAFAQVCDRMMVLLGSKGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVS5</accession>
    <name>A0ABR3BVS5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614724.1">
        <property type="nucleotide sequence ID" value="XM_066757255.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989571"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="49"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="115"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27475" checksum="35384567A40FB5CC" modified="2025-10-08" version="1">MNPIATSSSNTSTWMPNGLPKCNGALPPPMNDSDIINGTSEWKYEMRREAQLIIPGLYLGPFQASLNSNKMKQMGITHVLCIRDRKEVKLIFPRFPQEFKYMTLDISDHPDQNLITIFPSCRDFVEEALSMGGTVLVHCNGGIALSPAIVVGYLMWKFNWTADHALAHVQNKRYCVSTMSFQNQFKEYEPIYMAQKMVETAARRETTTNKRQVEEEDEEEAGYQRKQRYVQGEPSDMTMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVV3</accession>
    <name>A0ABR3BVV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_101910</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615238.1">
        <property type="nucleotide sequence ID" value="XM_066756461.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988768"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 15" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 14" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="17">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="213"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="295"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00006388"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022728"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0252518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="505" mass="54229" checksum="F8D3898394A2075D" modified="2025-10-08" version="1">MFFFSGSPPTVPVVSKTSGTVYEKALIERYIDENGTDPISGEPLTRDDLIDVKAKPSTIPPRPANQTSIPALLTALQSEYDSIMLESLEIKKAFQSSRQELANALYREDAATRVIARLMKERDEARQALSSIQSTTGFQRPAAAEEPAADIEMAQEGALPAEVEAKVMETNQALSSVRKKRKPAPGYKKADDIKSYTQINHVPSLHATKPAGITALDLAQDGNTVVTGGADKAVQVFDLEASKVLGTLKGHTKAITHVAFREHDGEPRLAISASADKTVRVWGEDDGKWGARATLSGHKGEINGLAVHPSGSYVAAGSADSTWSLYDLDTAKEITKYSAIPGIDGSFAYTSFAVHPDGVLHGGGTKDGAVRVWDARQSNSLAATLSSHAKDLSTLSFSENGYYLATSSVSGAPTVNIFDLRKLDILSSWTLPEENTIREVKFDPSAQFLSVVGTDARVYANKTWAELVTFEENAGDLVGARFGKLGSEIVLAGMDRTLRVLGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVW4</accession>
    <name>A0ABR3BVW4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAL0252537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_066756480.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0252537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="133" mass="14902" checksum="C9E1D21F29CAACD2" modified="2025-10-08" version="1">MQKRSDVCQVTMMPLARLWFPPYHVIGLAHCGLLYSPPSEFVVGSIKLLWTRVGASTNWVIGGIASRIQSRESAQIAWKYSWLQLGALLTIDNRLSCPPPEVYKKEQYKNCMCSGGVYYSSREAMTSILLKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVZ7</accession>
    <name>A0ABR3BVZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="4" type="ORF">I308_102446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_066756991.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="PH_PLC_plant-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
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    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
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    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1780"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="695"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="778"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2045"/>
            <end position="2124"/>
        </location>
    </feature>
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            <begin position="83"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="422"/>
            <end position="456"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
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            <begin position="323"/>
            <end position="336"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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            <end position="500"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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    <feature type="compositionally biased region" description="Pro residues" evidence="2">
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        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1689"/>
            <end position="1698"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1722"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1943"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2090"/>
            <end position="2109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="2124" mass="235913" checksum="02F3C45FEE3749F9" modified="2025-10-08" version="1">MDDPFAGPPMGSPLPRQRSRINLKHPLPAPPSTRSVASMAGNSPTSSPTPQRRSEITADALRSHLSSLLEQKSSQLQMLGTMGQEILKQQQELEERIRGFEDEEMEGDAIREETKDKLRELDEAMKSWGDQNEDMMKELGGKMPESLQGSAMVTVPSPTKAAAQPSNLTRRQRNAQHRQLDMEFATEIGQNLLVEVRRLQALLSERDRALEKLSEEKETWEQESQSILVAVRTAESSVDRYKEENWNLEVNLQELRSSVADMQDQLTKANAEQARLQKSLVSSREATEAYKTEAEKNAQAIEELKAKHETDMAQARRTTAGLQRDKSDLLGELNHERQRRVSARGRMSHSLSASPGMLSPNHTDSDEEDVFAAGGKGNSSPTKRGPGFDANDNALSPSQLYESDFDSPNPTPSKPFPRSPLGEMFVNENDELREKLRAAEQEIEALRSENERVRLGSFSKNESIDEFGARAPASEWEEDEHTISASSRGRGSTRGRRGGRGKNFAASIGRKFGFNRAVSGLSTPNAGDRSFNSTSSGTPDLLRPRDMSASPAPSTVGGETLGNVFGSRSVERLGSASPFNTPSIDSLKANFGQPTALADEIGAPMEPSATYVDAGIMTDEWSPEKPIMPDTQPPPASPSSNPPNELVANWVIETPRRGVTVESQFANLPPLPPPSTPPAAGDTTPTKKTIPLPMPSRLHQVFARPDSVDDSMSTTTDTDADDYESAAETIGSLTPNQTQSELPTDTEAYQTGREWPNESSAEDSDADEVQEQEHTMRGLKASSTLGLGLASAAAGGWAAAKQAHKIASRDRLAEAAGEKIVEKIVEIEKRIEVPVDRIVEVEKIVEKTIEVPVEKIVEVEKRIEVPVDRIVEVEKIVEVPVEKIVEVPVEKIVEVEKRIEVPVDRIVEVEKIVEKTIEVPVEKIVEVEKRIEVPVDRIVEVEKIVEVPVEKIVEVPVEKIVEVEKRVEVPVDRIVEVEKIVEKTVEVPVEKIVEVEKIVEKIIEVPVEVEKIVEVSVEKIVEVEKRVEVPVEVEKIVEVPVEVEKVVEKIVEVLIDKIIEIEKRVEVPVEIEKIVEIPVDTIIEKIVEVPVEKIVEVEKTVEKIIEVPVEKIIEVEKIVEVPVEKIVEIEKIVEKIVEIPVEKTIEVEKIVEVPKIIEVEKVVEKIVEVEKEVIKEVEVEKIVEKIVEVEVVKEVPVNVDVEKIVERVVEVEKPVEKIIEVPKIVEVEKIVEKVVEVIKEVEVIKEVEVEKIVEVIKEVEVEKVVERIVEVPVEVEKIVEKMVEVPVEIEKIVEVEKRVEVPFEVERIVEVEKVVEVPVEVEKRVEVPVEVEKIVERRVEVTVEVEKIVEKIVEVPVEVEKRIEVLIEVEKIVEKVVEVPVEVEKIVEKVVEVPVETERIVEVQKIVEVPVEVEKIVERVVELPVEVERRIEVPVEKIVEVERIVEIEKIVEVPVEKIVEVPVERVVERQVEVPVETERIIERRVEVPIEKIVTIEKRIEIPIERIVTVEKIVEVPVAANKSLLSDSASQSEPLVSSPLVSNPGIGLFDVTPGTSYDFLKAPPAIVRRVSADNFAATASSSADSSKTVETKSVPTSPVGESKRPLMNLPAAPSNSAGGGVGKKMSMGPPPLPTSPHPEDFLQRATSPTFQSTVKRRASTRTARSGAGAAVRTPVGDMPPPASTSRRPSKSSFKPAASAQVTPVMDDFKSRQSVRRHTNNTFASSGYASANSSATGHDQLTEHDRNPSLSSFDSYAGTVPKPRGVPTAGSTDPQTIHAITQTMIGEYLYKYTRRTVGKGQSSNRHKRFFWIHPYTKTLYWSTEDPGSSRASESSAKSVFISNVKVIEDTNIQPPGLFTKSIVVSTPGREIQITTPTQERHELWMSALQFLLQKQSPEANNTFAETTVRNTSRRALASIADEQGRLTMPKSPMSLRSFGSERHSLSNITPKANRSNSTMAHYPRSASTMGKRAGTAAYEYMRRHEVPQPFHGGHRYKGTYKGARVIVDDEFDMVSREDGEDMDTSFEGLENVRACCDGKHLVGQYHHHDHPNVPRTPARAETPSLRGWSMRSGGRRASNGLSDGESIFSTARKREERSKSAMGYRDRRDGAKSPAVGSLRNVKQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW06</accession>
    <name>A0ABR3BW06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615277.1">
        <property type="nucleotide sequence ID" value="XM_066756500.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988807"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045124994" description="Cytochrome b5 heme-binding domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="50"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0252557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="166" mass="18279" checksum="CA5633E3DC5E6EA6" modified="2025-10-08" version="1">MSLSNPLNLLLIPPLLFLAYRILVPAPQHTPPEYNSLPAEHPHVICHSTFTPAQLAQYDGTKGDRILLAIMRVGHDGKIVPNGERTVFDVSAGRTFYGPDGVYGNFAGRDASRGMAKQSFEPDVLTPVDKPLDDLSDLTPSEIENMRGWHQHFEGKYIVCGELVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW94</accession>
    <name>A0ABR3BW94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614565.1">
        <property type="nucleotide sequence ID" value="XM_066757096.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989408"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF1">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="9824" checksum="6677D17BB1936668" modified="2025-10-08" version="1">MSEQHDHRVIGGYKAALNNPRVSEEAKQNASNAIDNYENRGNEAAEDFSNEVDNNTHHSSRAVGGYKATLKNPNVSDEAKQQAKEVLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWA6</accession>
    <name>A0ABR3BWA6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615390.1">
        <property type="nucleotide sequence ID" value="XM_066756613.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988920"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF2">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="20"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="467" mass="50598" checksum="0E277C0EA75C02EF" modified="2025-10-08" version="1">MSDPISLITDSLTLPNGIRVPNRLVKAAMAEGIGLGGGPPQPNHLRLYEQWAQGGWGMIISGNVQIDPKHLASPHDLTITPSTIDRIAYRRLASAVACSNSEPPLLIMQISHPGLQSSSTVNFSRLPHEPAIGPCSARPDMNGGIMGWLWGHAVWPRKSREIRAPEDWLSIVDKFVAGAVLAEEAGWDGVQVHAAHGYLLAEYLSPLTNPNPMQLPGVPDSVPVRLHLLYLILEGVSRKTSKSFIKAVKVNCSDFVQGGLDEDQASELIKTVVSWQLLDIIEISGGTYAQPAFAYPETLSSPSKRQSLFSHFTTSLLPLLPPPPQGPAILLTGGRHNRELIASSLAERACDIVGIGRPACIIPDLPRRIILNRAVADDEASFGTYTIPHATAVKFLLGGPSTAKGKGIPLVGAGVSTLWHTWQICRIGRGVEPDEKMSWFRGLMVEEIWEGMIVRGVTLMLSWRGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWN6</accession>
    <name>A0ABR3BWN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615511.1">
        <property type="nucleotide sequence ID" value="XM_066756734.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989041"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="276" mass="30264" checksum="70E1983F1E78C2B1" modified="2025-10-08" version="1">MRVRGNYIFQSPILSRCVHSLLRATPLPAITPASCLQQAVTPLNSPPTGLPSRNPGPVFPEGLVSYFATLVIISRSLVMALTRNIKCVVVGDGAVGKTCLLISYTTNAFPGEYVPTVFDNYSSQVIVDGMTVSLGLWDTAGQEDYDRLRPLSYPQTDVFLLCFSVVSPASFENVRTKWYPEIQHHSPGTPIILVGTKLDLRDDPAQIEKLRERRQSPIGYTQGSSMANDIKAAKYLECSALTQKNLKAVFDEAIRTVLNPNRRAGKAKKSSGCLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWR1</accession>
    <name>A0ABR3BWR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_102216</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615544.1">
        <property type="nucleotide sequence ID" value="XM_066756767.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989074"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="13">
        <location>
            <begin position="268"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0252824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="389" mass="40439" checksum="581A11D689B8D9AB" modified="2025-10-08" version="1">MVNPVYIVSASRTPVGAKDGSLATVSAPQLGVVAVKHAVEKAGIKPEQVEELYMGNVVQAGVGQSPARQVGIGAGIPETTDATTINKVCASGMKAIMLATQNIQLGQRGIMVAGGMESMSQAPFLVPRQNPAFGGFETKDSLVVDGLFDVYNKVPMGNCAEHTAAKLKITREDQDDFCLSSYTRAQEAWAADAFADEIAPVTVKGRKGDVIVKEDEDYKKLLKDKFRTIRPVFVKENGTVTAANASTLNDGASAVVLASGEVVEKEGLKPLAKILGFADAACAPIDFPTAPTLAVPLALKNAGVSKDEIALWEFNEAFSVVGVAAERVLGLDRSKVNVKGGAVALGHPIGSSGCRIVVTLVHALKKGEKGVAAICNGGGAASAIVVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX06</accession>
    <name>A0ABR3BX06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_102053</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615381.1">
        <property type="nucleotide sequence ID" value="XM_066756604.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988911"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="11">
        <location>
            <begin position="113"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="174"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="644"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="874"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="581"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="685"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0252661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1079" mass="121116" checksum="80BA3C516419E3A6" modified="2025-10-08" version="1">MSRQPTGDSTPARDLLLPHPAEDLSADDDLLSWVLVDQLGCMPNTKLGVHPQQVKFVGPPFKTDEVLNIVRETVTKGDLHAAMKRLQDKLTTNQKERFIQHLRRYLLCLQPTSRVEIHLTSRYSFVTGHTELAVFATRPLARGLVVQELQGSVVPLPDEWREEMDIGDDFAVEAAEESDSERDEEEEDVDSGAITSTSGRRGKSKTKEECRRQGQRRSDRTKRRDFSIVWSGLKRCYQLFLGPARFLNHDCNPNVELLRQGNYVTFRVVRPVRIGEELTTFYGENYFGKGNVECLCLTCEKNHRGGFTPKPESSRRTSRDLSRDFTADPVCIRGRSSVSRSRKSISAGPQPLKYEGAVKQEPFSDDEQAVSVGLSTAASLSTEEECETPIDNVSNIPSVASPFGESLASDVDSVLMPPRRERYARKAAQNSKSWLLLKGRGSKIDVDENLAFVGDEEEVPPDFPRCATCAKPLSDQIWYNGRYFDHCQRCVRHALVFQLPWPAHKPQEVQEYPPAYLIPPGYIPPKISTVPLPSLSKNKPAPRVNPIATTPTPSPAGTSMEDRAHRLRKQIEIEEFIVNSLREAAWSVQEAKELAQEAKEEARRKKKEEKMRLDAMRIKGNGIWQRYEYVDEEELKRKQEAMWRVEPGTTRRGTVRKTPQVENSNEKKAKQTGKEADGTVTAITDEARAKKNEEKRRKRAEEKLKREQKMREEERKKEEKRLKDRERKRRAKEMRKEEKDRLVQTAVSNYTSTSERDNGYAQPSVDIDEEDNEDLEDEIMVATAPELVAYYSPEMPKATELPSSAIIPARPLARRISKSTSQSPLSSGFKALTSSPQTTIHHASHSCSRLSTQELCFIKPKRKKHPGTIKTLKDQATEAAPAISEQGTSEKDCGMSPTLVGSSQMGKENSLLKEDKEKGIGPASHSPKSIISAMEFTKQTAVISQELPSGAYGGCFPPPFSSLRATDHQPLTTMSAPNLSSTLSRPDTFPEDMAVPSASFSSDASFSLTRAAAIKDVMDGEPLQEKLQGLVQNLGPSIATKNNKRRLSESEEAALQVQLPLAKKKRTFFPSIFQHPVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX32</accession>
    <name>A0ABR3BX32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615660.1">
        <property type="nucleotide sequence ID" value="XM_066756883.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989191"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="449" mass="49561" checksum="225C0E2820F55A62" modified="2025-10-08" version="1">MSVLKSSAPSLRPLTKSNLQSITRKPLVRPTALFRCQSTSTVSSSSKPAAKPNELAKVIRDSIKLSGPISASRYMQFCLSHPVHGYYSKGDVFGQKGDFITSPEISQIFGELVAIWFLTRWMEADSPTQVRIIELGPGRGTLMDDVLRTLFNFPGIAASINSVHLVENSEAMREVQSQTLSPRIEGKDVKLNWYTSVEEIPETKNEFTLFVAHEFFDAMPINVFEKTDMGWREVLIDRDPSYSPDLPTSSSPSGLRFTLSSSPTTLSTILPSTSPRFANLPSGSRIEVSQDSYKIMHRLGQVINQGPGGCGLVVDYGADKTFASSFRAFRKHEIVDVFEDPGNCDLTANVDFAYLHESLTGIATSLGPISQAQFLLSLGLQPRLRKLLDTAPLDRREAIEKGAKRLIDVLGMGSQYQVMGVVSGEPEMKEGIYPFPMKKETVEGKVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX37</accession>
    <name>A0ABR3BX37_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615679.1">
        <property type="nucleotide sequence ID" value="XM_066756902.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989210"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="11564" checksum="43DA03B471ADE4E5" modified="2025-10-08" version="1">MSNPNEPSKTNGQLNSLIGSGKTLVGNAIETAYSAVGGSTEPSSWTTAGQKQHDKGEAEISAAKTQGYVEGVGDRLEGKKDSVVGAITGDKSQQASGNVQHDKGEAQMNVNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX42</accession>
    <name>A0ABR3BX42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">gluconokinase</fullName>
            <ecNumber evidence="3">2.7.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gluconate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102344</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615670.1">
        <property type="nucleotide sequence ID" value="XM_066756893.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989201"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="230" mass="24962" checksum="C96898AFF5B9F804" modified="2025-10-08" version="1">MSSKPQQELAVPSHLPAPVLIIVMGPASCGKSTVGQDVANHFQIPFIDGDSLHPKSNIAKMSSGTPLTDEDRLPWLALIRSTAERVCKEQSDKVEEKNRSVEDGGLGRAGVVIACSALKKWYRDILRGTVKADPPPAEDLNESHPDDAEHPATSSLKTYFVYCYGTPELLKQRIAARKGHFFGQQMLDSQLAVLEDPSGEDDVTVADIDGTREEVGERAVSGMKKLLGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYN9</accession>
    <name>A0ABR3BYN9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615665.1">
        <property type="nucleotide sequence ID" value="XM_066756888.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989196"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="117" mass="13167" checksum="404E2F971546DCE4" modified="2025-10-08" version="1">MGNRQSQQPAPRHDFNGPLFGGHYPGDFSIIRGRGMSDLNKALPPLPNIKKARFGSDPPPWIFYKHRPPDENLANTRYCYPGALYPEAPPEQKISPPPAYGTWNDEKSGKTARKKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYR8</accession>
    <name>A0ABR3BYR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066755482.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RING-H2_zinc_finger"/>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155:SF627">
        <property type="entry name" value="OS06G0192800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAL0253547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1715" mass="184717" checksum="0889316EB9DD24D6" modified="2025-10-08" version="1">MSKNNPAGAARKPRKKPKASSSPAGHSFPLSTSPAPNPASSGSTPMAIPMAIGGEREREREREREERPIPRPYLALAPSPISSMSPSAAERMVLPSHFIRQSQQAQLQQSQGHHQVSTTAEAAGPGPSTSTSSLNATGSTAQAQAQGQAHGKGKEKGQKKRTRYASGLLAPPAVVPGGTPGVPRVQVYSQPGKRRNLSTTNLGGGGAGSGTEAAGTRMGVGLGRDRDGRFASRTRLDTTLRTHNPSQISLGQLGQVLNSDPSSSYDTSGEPSQQTQQQQQQQQQQQPQRRRRRVVTGDNNEESRGTRRRLTVSSREEGRALGVARGASMRRRNLWDEIPEAIVQETGEPPPPFPFPTSSNRLPGFHTSQSPTSQADGGGGGGGEHGDGRERPPRSPPPSWEQAVGLAPLPTPAASSDNTPRTTTAPDTPSVPRLVIPDQSHSLSVSPTSSRYESAPSSPFLSPVSIVDTPTLHPQTPAIVVPPPLPLLSNLESISTSASTLANPSTAPSTSAAIALDQDPDANTDGMTAEERLDRKLWNEDLLAGYSLEERVRREWDRRKVREIEQSQSQGWGQNGEEEGEERGNELVRGSVTEVGGVGTLPEMQLPKAAEATDMTEETERATRTENVKPRRPSSPSLEKGLGSKPSAGSSAMPSRSIEASSRDVEPGSVPKAEHKHGREREPKVEHQFESDPRPQWKHDQEQGHGQKQDTKWQPARSLPEIGAAAETGEPSLSRKQATSIHTSTSVAPSTAPAGPPLLSPPIKSPSHEHEHEPQLPFKPKEKVGGKKNAEVVIDVDAGKIAEQPSPRFEPPTAPTSTSASTSTPNAHSKEKGKMEAQTQMVEEKHSLATEQPSERVKEKKEKEKTKVSAPELSSSLPKEKRKEKRAIEKKSSQPLQVLRPLFDKIPWSSSPNVDTAGIGVISSQDKPSTYTTHSGESTEKVQGTGTSFEKRRESGAPQGRRLNEDLQRRKSENDLGFTGESPREEDKREKTGLPPNREAALKRRDLQLQSETPKIRSQPTQPQESTAQYKSALPRSTMPVEQPIPTSKPKADVAQSVPTKVMVVEKKQHKEENLLQSLSGPLVDTGEPEPGLVPKSLPQAQPSTSAAQRQYSPIVQARADQEAKGKKDKRISGESITALAASSADLLQLLESSAEEGPSSSNSGLRDANQSRIEEPEGDMTRESTSGLDTTLTRGPSSLNPMAAATKKKIPPPPPPPLSRSRLHLSKSAGALRPSERVGQGKQDGRVACEDGTQSARAPLVPPLPPQLPKRRPPPPPPPPRHPAAIARLPSPPPSQSQAGPRGRASPPPPPLPPRPRPLSGVSYRTISSVSQVSSAGPPAQAQQRGQALESERDGEEGDSSERENVSPGLTRRPLGPRPAPPPRPTLPSRLRLFGNNQTNSSQRMDSQTLDVPQCLEPGLEERDRAMDTGSRFVEHIEREGIPPLPVSPPAPQTRPRETIRPISVSSALTPTPIPALRLNNSSITTNGSRPSPAERAHSDFPPLCTHSQLRINQMNERESDNRWASSVDLRERPLSPAISVTPAVSNDDRGDEDGSRVSPVETPRREEGGQGPGMGLHSQAQGQRGIREYTDLDLFVSRLEGSGREYEGYSQLTTFLGPSKSTAASPEAISTLLPGLITVDSRRTTPQGKVKLKLSLLGVRVSKCPICLSQFRGGEKGVLTPTCGHAAHQSCALRWFREDRRCFICREILKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYS1</accession>
    <name>A0ABR3BYS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066755476.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
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        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
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        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="3">
        <location>
            <begin position="333"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1157"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1171"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1207"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1218"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1266"/>
            <end position="1282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1309" mass="147218" checksum="1A632A271031B184" modified="2025-10-08" version="1">MSSPEPEEPRRGSRIRKQVDKFDASQQNGKGKRKQIEDLEDDDHEGLITDPEDGSDHEPTPKKKKPTAPRKPRASAGTTKKRGPKAKTKPTAEGAKENVEKTDSPLFNALQQPDIALQPLIDEWIETYQQAAGDETSEQKSIHELVVFFIRCCGMATEIEQAEATDDDGIPDVIERVQDESVRVALATYPLISKAKNFKPFKSNLNEFISHFISSLALTPILFHTVDNTPHSSLLIPLLLNWLMCMSSSTLRPIRHTSTYMTLKINSALCDVAADVSKDLSVKQRQRDAEVRKAGATNAAQKRMKAAEDRVKEVQERKQTLEELMQEIFDVMFVHRVRDADPNIRTDCLRELGVWAKKYPDYYVSTSYLSYFTRGCNDTHAHARLETVKALSNLYSRETFINNARTLTMRLAPRVIEMATRDVDLNVRVVALQAITLIDKTGILQDEEDEERDKVAKLVFDQEPRIRKAAGGFILGLWEERKEALKAVWSGLRANKKRRAAKITEEEMSHYLDWKSLAAVLLYTSKSLDDPSEQPTSLKQTPLIPFLPNQQMTRATAAVESIGAEHELWKDWESLVNYLLVDHSTNEEDMWLLRDDEETFMLQVLLACIKREENEEDEPDRTKTLIKVLPRLFAKHQGDVGRMAGILSIPGHMKLSLYLDMRMSSAYESLWDDISKQFLQYTSPIILTASISAISHLVANYSLSSINEAKLSELHESLFASLRDAIGSEDVALVTLEDEQISQLEAILLRITLLQRSMDLVDVMEDEEGQQSSGWDIICAFADRGKLGYKEEATMVDYAVQIIFLHVTWLFKRFTKEDTQDATRVDLLSTRRDTALQTFNQLFLGETTNTASAVRCQAFISFINTYVLFTKRAEGRGGAPASDVCSVAMPDEVQHRLGGTFQAVIEKYASVVETRSAGREESQQLLELTPDEIQEDFHFFQLVSVFVGAIRCGVLEVEHAKEPLAHYGRFGPTYDAIVKKLIDVLRDEGIYNKEADTVQHVAGSALQQSFNIFLDSEEDEPIAPLALARVIATAFVIHGSQFAILRQLHPSDACDFHLEALDFVSRKLSTTVKQEGNARNKEQRSRLTKKKWAVLTFFKMLIPLLGPVTGKDALKIKAHLEDVIDSSGVQLTTNKGWDGYRAYEKRLIGIASKDPNVKMASKKVVEREGTEQGDEEDVEEVDDEEAEREKTPTAQTRPKPKGRRRSNTITHPSPSAVSTESSLTPAPSSSPAHKGLLSPSQHAGPQGQKHAREDSLDLQLTPPPADNEEGELQLDLDLDLDGVEPSQRMEEVAVEPEQPSLKRRKTRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYS8</accession>
    <name>A0ABR3BYS8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-binding cassette transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_100935</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615783.1">
        <property type="nucleotide sequence ID" value="XM_066755497.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987793"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="560"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="953"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1050"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1130"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1235"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="293"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="666"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1034"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1331"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="883"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="884"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="900"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="911"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0253562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1670" mass="184084" checksum="DEA7D11E82B30237" modified="2025-10-08" version="1">MDVSKIDVPSPFLISTIRTVPSLIVLLLPLLFSIPPFMQLGDRLAPVFSDFVTLRSLVPPEPATSAQKADEQARRPKAWKEFVLAAFSLAEAATWTGITGWKILQLAQGDGATLRDTLLFVGMVVVWLGIFSTFALRPLTTPPWSVVIISILLFVVSAWTIGQAWYMRTITGFLPSWASSGRITLEFLNIGATAAIILVLGSLRLASPEVLSRLPQVAPDDDVTLLSWMTFSWVDSFIRYGNSQELEPEDLPPLSMTQQTRIVFEKFKQAATSKLVYKLFLVNKLDMALDGSLTLVSVILNYAGPFFLNRILQGLDTRSREAMSRAYVFALFALFASVFKALVDLLHLWHSRRAAVRIKAELTAAVYDKALRRKDASGIVSKTGAGDKESDGKQEKMSNADSGKVVNLMSGDTTRIANTVSGAYFIYSAPFEILVASIFLYNILGWSAFAGIVVLAVAAPLNSFVSSRSVKITQDLLKARDKRIGVMNELIGAIQFIKFFAWIEQWKGRAAEARSNEMKQMIRSLINNVWFALLWSLAPILVTLVSFFCYIVIEKRDLTVSVAFTAISLFTMLRLPLNIIPSYIVIILQSLVSVQRIEDFLAEDEVPDWVSSLKRSEAQNDEPIKIGFENASFRWNTGKQSSLSETIESSKGKQPASAPAPLDGSVVTDGSTVVEEAFFMLSDLNINFPIGRLSVITGPTGSGKTALLTALLDSSSGLRNSIAYAAQTPWLQQTSIRNNILFGEPFDEERYEMVLEACALNPDLDALEDGDMTEIGAKGVSLSGGQKARVALARAVYSYTQHLLLDDPLAAVDSHTAKHLTDKCLNGPILKGRTVVLVSHHVELLLPSTDYLVRILDGRIDIQGTIQDLRERGDLDGMVASEEAELHKEEDRGKGKSQEEEAVEGEDADVQEIKKEKNKGPGKKLIQDEERAIGNVKWETYKLYIVAATYTTWAWTVLVLILSQLCTVAERYWLKVWGEAYSKQHVTTLFTMFKPAIHDLTSHYFDNELHQHVLQHNVSENVTFAVSEAVSVDISGITSQFPSAETNPTFYLAVYTVIVLGAAILGVASSGIGAWSSYRAAVTIHDRLLDRIMRATVRFFSVTPLGRIINRFSRDVEVIDSSLNGALRTVLIYVASLMAAIGVVAFIVPWFLVPAALISYLYYQYSVLYLRVGRSLRRLEATLRSPIFSGFAELLDGVISVRAFSAEARFMEQLCKQVDQTNQAFYYYWMMNRWLLLRFDFLGAISVALTTLLALSGAVPAGSAGMAIVSAQSFVSACYWVSRFWGQLEMDFNSVERVQEYLSVPQEPPAVIPSNRPPAYWPANTGAPDFLSVRDIEIKYAPDLPTVFKGSFDIKGGEKIGLIGRTGSGKSMLGMSLLRFTDPTSGSIFLDGIDITKIGVDDLRSRITYIPQDAVLFSGTVRENLDPFAEHTDAELYDALARVNLGPQGTSPLASRAPSRVASSRRLDAIIAEESAARSSASSALGSAISSANARTIITLTTEVSAGGSNFSQGQRQLVAMARALLRRSNLIIMDEATASVDFATDEAIQAAIRSEFKDSTLLTIAHRLSSVIDYDRLLVLSNGEVAEFDTPINLLRKDGSLFKILCEKSGKYKELFKAAEKKEQEDQEKESGTKNLLEITVLFTLYTNSIEPLIPSYTIIHTLAIDKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZD5</accession>
    <name>A0ABR3BZD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein L9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615973.1">
        <property type="nucleotide sequence ID" value="XM_066755687.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987986"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="5">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="215" mass="23919" checksum="0CF2BE5CBF4D52A9" modified="2025-10-08" version="1">MLPLSSKVLISSVSPSLRAFSTTSRSLAKRETFVELLQDVPGLGKTYDRLFVAPGRARNDLVPARKARFVAFKDNKQRQVLRMTEEERKIHWLQVEAPGATPQNPREPAEGSQQTPQHLLDSLFLLPSTLHFPLRTVSPTSPTLHGSLSLSNVYEILEGNHGLSSKDVEVSWVEQEAGARMKELGTWKASVKLRTGGREEQIVDIKVDRLVSGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZP7</accession>
    <name>A0ABR3BZP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P/MRP protein subunit POP5</fullName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615464.1">
        <property type="nucleotide sequence ID" value="XM_066756687.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988994"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016819">
        <property type="entry name" value="RNase_P/MRP_POP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023803">
        <property type="entry name" value="Ribonuclease_P_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045085097" description="Ribonuclease P/MRP protein subunit POP5" evidence="7">
        <location>
            <begin position="23"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR023803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="210" mass="23228" checksum="EBD36F1C1E70FA34" modified="2025-10-08" version="1">MVRFKNRYLLVEFLLSASLSSTLDTHCDSTNPTIPKESALEDDGSEDEEDEEEFSPIPSLPFVIPTILPDSQLGDEGGQGIYKAVRSTVISVFGDEGWGRIASSFRVIYHSPLTTLTFLRIARPHYRLLWSALTFINFLGNTPVIPRVIAVSGTIKKLQNRGIAYHRAMVGALISAGVDKNKAGISGGGGRKLEKEAEQEREEMERMQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZU5</accession>
    <name>A0ABR3BZU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616125.1">
        <property type="nucleotide sequence ID" value="XM_066755839.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988140"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="90"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0253904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="232" mass="25399" checksum="681EE49D6D002604" modified="2025-10-08" version="1">MKIVSQDDVRGYNDATIVGGIKGAFLAAAICIPGHMLLMKRSPYFRALPLPLKALGHVTITVPCISVAAEKGGEAYTRSQYSGMGQREIDWELQIRNEKWEKMSKLEKIGDWAARHKYGIIGGGWAASMALAFGIVARNPYQSTSQKVVQARMWAQGLTVALLVGSAMATGFDASNSSAPVESTDHSWRRMLEHDEHLTPEERAQLRDTKDSNTVKEIQKAVSQRKAAAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C077</accession>
    <name>A0ABR3C077_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Impact N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616260.1">
        <property type="nucleotide sequence ID" value="XM_066755974.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988276"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="3">
        <location>
            <begin position="95"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="274" mass="29860" checksum="4C59C796BEB4982C" modified="2025-10-08" version="1">MPPSLHSWLHPHDPPPTLSHSPPLHHSSSTFLTFTISFLPPAHVTTEASLAKEARRIVRELDVVGRVGPEVMAAGEGAFQEGEGRAPGRAPGKERAREPDHRMWACRALCLKEGKNGTEGEEAFQLVESFSDDGEKFGGERVLKVLREQNAVDVLSVCCRWYGGDMIGPIRFQHIATTVQTSLKSLLELVQLRDLRQALDVLDEEIASLRATSVNLGSSQTGLRPSMVSSSGDNEGTAQGKYDSIQDVTKLERLVSAKEKTVAVLLKKQTSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0B4</accession>
    <name>A0ABR3C0B4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616301.1">
        <property type="nucleotide sequence ID" value="XM_066756015.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988317"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0254080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="71" mass="7820" checksum="8DF0A83E9E0B94B4" modified="2025-10-08" version="1">MNDNNASRVKVHSSSLPSAVKHPRLACLMCISKVNHDYSESRADEDTARTTLTTISIILDTFTFLPTNVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1C7</accession>
    <name>A0ABR3C1C7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616186.1">
        <property type="nucleotide sequence ID" value="XM_066755900.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988202"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10642" checksum="80600E3957B2EE22" modified="2025-10-08" version="1">MPDIKLKNQPFDVAFHPKEPVVFSSLLTGQVCAWSYDDATGETSSSWSVRPSKRTARALSMEESGDEIWMGGKSGSLFQLSTRDGSMTRERDSAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1V4</accession>
    <name>A0ABR3C1V4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615967.1">
        <property type="nucleotide sequence ID" value="XM_066755681.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987980"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF190">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="165" mass="18072" checksum="E2626FCD864BB45C" modified="2025-10-08" version="1">MSPVEGSPAKPEDYPHFMSVAHEQALKSRSEGGIPIGAALVHLPTARIISRGHNNRVQLSSNVRHGEMDCLENLGRVPEGLLRECAMFTTLSPCIMCSATCILYKIPTVVLAENENFLGGEQLLRDNGVNVVNLDSDEIKKMMKDWINSPGGKVWNEDIGEVTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C2K1</accession>
    <name>A0ABR3C2K1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616207.1">
        <property type="nucleotide sequence ID" value="XM_066755921.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988223"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0253986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="310" mass="34084" checksum="9435A365EF596F91" modified="2025-10-08" version="1">MVSFQCDACADTVKKPKLDQHRSRCFASFTCLDCSKTFKNPSEYKGHTSCISEAEKYQGALYKGSKKEQTRSQPQSLTPVSEAEPVASAPSIHPSRLQQMTSSSSDNQRGGFQDRGNRGMRGGRGGRGGYQNRGGFNANGGERSYASAMNKLESAVGMRSWGSPAVTETASENVEVREEPGEKKDEKKRKKKGDKGGTGSRANSKNARSEEPSSAPPETLEPKSKKRKIDDTDIVDDLENPSPAVSIEPISSKTIKRLKKRLSKLEEKKEMSLRELVDSLQKDEKKAVEAAEIMRGIKISFRDGSWVLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3S0</accession>
    <name>A0ABR3C3S0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_100081</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616561.1">
        <property type="nucleotide sequence ID" value="XM_066754660.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986939"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0255284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="162" mass="17941" checksum="8FC89A6D00945B62" modified="2025-10-08" version="1">MIACSARGSPFLYLRTASSRAFVTSLPRQAQPPPPPPTSTLSHSEYEHVSERDMETLNESLEMFCEDFGNGNWEIEYSSGVLNLTLPPYGTYVLNKQPPNLQIWMSSPVSGPSRFEYVDGSWVHHRKEGVRLGELLSGELKEILEKSGNEEAAGGWEGVGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4B0</accession>
    <name>A0ABR3C4B0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616732.1">
        <property type="nucleotide sequence ID" value="XM_066754831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987117"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="214"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="737" mass="79194" checksum="20226BF4A1D53A3A" modified="2025-10-08" version="1">MADTTKYGNAVEFDVDLHSIYAAYIGLFESTNTDWWEKSWGGYFVSFNDFLGFGWEVMVVVDSETGKPHVAVRREQIALFARMIRTRFGESLSKDPPTTLPLNPVPTRNLALRRLVTVRDLSAYRKLAASLPAAELSYLRSRVRSGEAAVIEQLFYAGGSSGERETGSVGVRDNGVGYTFACVKANWWEKGGPPYGMIPGQGRTHSGNTGQGSNKGLVLEIGLAVLRCANLRALGVWPPVPADNYRKSHYVVEEWVDKRTNHNPPTFPRAYAFGQSEFVAEKRVETILDATLNALASQENDGHANALILLTVGEPVPLPLPSSSTLPNNILQFDVLALEYNFLRRAQAQGIPGTPDRQQPLTCLGSLLQTLQIPIQPFAPLGNAGNDAYYTLLAFQKLVMGETRLPDILFNQPGPYAPMSFPLAHRSSVALPFPQYPAVALPVPAMPAAVGDSRRNSSSSNRAASGLVPPSFPPSSFDRTQGGRYASEGSPRRRPVSVGDPLNVYTDSPNRTSSDLRTPNGLAQDISPVTGPQQRKRVPVMRSQTVFWDDAAYADSNSARGEEFKAPLPNGLTGNSTPYMQEQRSRAREGPPLSRSAGKSTWLGSQGRSVSYDAVGSAGGMSGTSTAANSPVDKPFGSLSNISVARTGVEPSGLLSTSLYRDTNEGAHSSGTGSSGNTKPSTGSSGEVRGTGQRLRYSMSSIQSVDDVKSGAKNGKEKKKGKGPKDLAGAIAKFWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4M1</accession>
    <name>A0ABR3C4M1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616846.1">
        <property type="nucleotide sequence ID" value="XM_066754945.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987232"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="693"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="568"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="769"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1063" mass="115651" checksum="4F4CD78F1ED13A88" modified="2025-10-08" version="1">MSRVRAASGSSIKVKSTVSGSKSHGDLLSVIERIDDDLVEGDEMELLDEEGDCDKDESFRRRKSLGRSNDGWKRVVSEDSRHESTDEGDDASFWDNSARYYHHLHSHPSSRTGSITASPERSPVASHSASPIIAPRSFPLPQNGSGPPLQGISKSLSPNQQFLQSRLPPTFPSCPNGTVLETVFPEHFCPAAMVFTPTTQEWKDFQAMPEWKTLHESKEEPSFSGSSSEDAAQDQHSRHTSLESDSDKFLSVRPALRSTISAEYLGPENYHTPDPGSPSNNSGETDDSAKPSYVPNIISPSPVIYPTDRKESSLAPLDFSSTAEESQVPDGRTMSHGALGLENTGPALNSNDVVVRNPDHPAPPARWNSVGNRDSLLTVHKSEAPTLPRTKTKRELEREKLLEMVDDELEAENRLAWKNDGWGGGVQQIGSGLGLDHVKSHSTSDIQSVKPIEEDKRPVPDVRVDPDALERPSSADPVENSKHGLQPLNPFDSGFGQAQNKLNHKTPFSPTHPFKPSPLNAEPIVAGDAHSNPSTASVTPHDLTPTGEIPPPVFPEMPATSLDSIRDYARGLAPPGSPRSGDVIQPKSPRSTRKRDTNRVSLVAGRVVQPFTLPASTALPPSSKPPDSPSLQAFSPFRSPTLSRPSSAALHHPSYPRFDSTLSIAPSTGVPSECGTPTEEKAGGMGGRGIDDYVILKEAGKGAYGLVMRAKLKGPKGEPVGDEVIIKYIIKARILADCWKKHKVLGPIPVEIHVMDQLRHLLYTPPRHMNPWDPARSRSEVTKPNGASGSDGEAISALGAPGSPPSGSENGRLYSSIQKHIAEEIKSSPQRGHPNICKLVDFFEDKEFYYLVMPCFGNGMDLFDRVESQPSGLQSFEVRSLIGQLSDAVQFLHANGIVHRDIKDENVILDGSGHCQLIDFGSAAHWRPGKKWDTFSGTLHYASPEILRGEMYGGKEQDIWALGVVTYVLLIGETPFSELPDEVLHGLASDSKAYAALMDRCGAPHEEEGEEMDGGGKLCDAADLVMRCMELEVGDRPSADVLLEHRYIKGRDGWVGKEGWIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4W4</accession>
    <name>A0ABR3C4W4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_100452</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616924.1">
        <property type="nucleotide sequence ID" value="XM_066755023.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987310"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="11">
        <location>
            <begin position="187"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="14">
        <location>
            <begin position="294"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="13">
        <location>
            <begin position="458"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="121"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0255647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="613" mass="67575" checksum="83E5204FCADCC075" modified="2025-10-08" version="1">MASPLTAGFCERATSMEDVSECFDSVVQVLNVKKIASTDTTAVDRYRAILSDGQYFIQAMLATQLNHFVESKQVDKHSLVKVVNFSVNSVSGRKLLIILALEVVPWTDEKIGNPVSVDQAKTGASASAQPAGAHSAPPQSATTAPASARGQAPARNAPSARSGNTKPKGDLGPLYPIEGLSPYQNRWTIKARVTQKSDIRHYSNQRGDGKLFNVTFMDETGEIRATGFNDAVDNFYNLLEVGKVFFVSRARINIAKKQFSNVNNEYEIMFERDTEIEPCADESVPQVKYSFKGIGDLGELQKDDVCDVIGVVREVGELGSVTSRATNKPFAKRDLQLVDQSGQSVRLTLWGKQAETFQADDQPVIAFKGVKVGDFGGRSLSMFSNATMTINPDIPEAHSLRGWFDAEGHNKHFTAYTNASVGDSAVNTAAGAGTRPAELKTIAQAKDEQLGMSEKTDFFSTEATVAFIKKDPFSYPACANPDNCAKKVVEDGSGWWCEKCQRRWDEPIHRYILSLNVMDYTGQFWMTAFNETAEQIMGISANDLMKLKNEGNDLDYDAHFAKATARTYVFQMMAKQDSFNDQVRVRYQCRKVATPDYVADSAYLSQMISQMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4X4</accession>
    <name>A0ABR3C4X4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616502.1">
        <property type="nucleotide sequence ID" value="XM_066754601.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986879"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="136"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="363" mass="39425" checksum="96A3030334FE795D" modified="2025-10-08" version="1">MSLPYTVASTVHLSSATISKLQDTFTSFIHRTDPSSSPFTKEELSKIQIFFTTGRGLPVDSLADVPNLELVQLCSAGADKAISSPAMKAYVEERKRGKGKGNSKEVKLATASGTHVLSIPNYVVAMVITLLHQLPRQIIGARTEQRWLSEAECDMDGQAYYARKTFHRTAGLLGYGSLGRETARLLKAHGMRIIAANTSGKATPQDGYIIPGTGDKDGSIPEAFYSTKDPKSVKEFLNQCDVLVANLPNTPDTQHFLNKEKLEMLPKGAVLVNVGRGSLIPSNDLLAVLDAPNLFGAALDVTEPEPLPDGHPLWSHPKCIITPHLSGNTEGEMEIAADVLVFNVERMKDGEGVVNEVKWERGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4Y5</accession>
    <name>A0ABR3C4Y5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid:diacylglycerol acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616698.1">
        <property type="nucleotide sequence ID" value="XM_066754797.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987083"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="79097" checksum="1CE0F7769127727B" modified="2025-10-08" version="1">MPPRKKAVNPSPSRLASPSPSTSAVEGLPVPATPSSLRQRRSQNTNKEAGGKDNVEFNVKLKKNNDGRYHLLAPGTPFDEIDLSEYSFFSHHDETPRQDKPTSWKEWIFGRKFFFSAGILLGIIIAIWAMDFSSLPADMKDVWTSLPTSLDPRDLVSNLTVIETARRALENRDFTVGEKVKTEFGIEKHHPIILVPGIVSTGLESWGTEVVARNFFRKRLWGTSTMIRAVLSNKERWVQALSIDPETGLDPPGFKIRAAQGLDAASEFIQGYWIWQKVVENLATVGYDTNSMDLAAYDWRLAYYNLEIRDAYFTRLKNKIEMFHWHNKQKVVLCSHSMGGTLLVYLLSDPIADGFGGGGGPNWVEEHIEAWINVAGSLLGVSKAMTAFLSGEMRDTVELHPAGSWVLEKFFSRRERAKLFRRWPGSSSMWLKGGNRIWGNENHAPDDPEDATDTHGRFFSFRHPGVPPDDKSLSEWTVSPNLTVNEAGPQGFETDVKKLKENGKDHRKWSNPLEVQLPDAPSMKIYCLYGHGKETERSYWYMQGEYEEDESRSDAEGDQAYCDASDPSNGCDNSVINRTALDFPLARRHWIDSAVTIKGSSPEVRSGVKFGDGDGTIPVVSLGSMCVKGWKGKTKWNPAGIEVITQEYKHSPEGLDLRGGAQTADHVDILGASPLNSAILKIAGGRGDLVTEQIGSKILEYTERMDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C526</accession>
    <name>A0ABR3C526_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein MPE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_100532</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617002.1">
        <property type="nucleotide sequence ID" value="XM_066755101.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987390"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="11">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="324"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="384"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0255725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="64530" checksum="E5F351BF18C64A52" modified="2025-10-08" version="1">MSTVFYRWGAGRDESRVTFDGTHISVFDLKREIILNNKMGNGKDFDLSIYDNVTGEELKDDNQQIPRSSSLVARRLPPSLGKGRGTAADYIAGTAAAEALTGDHRVESHARQAMLDKNLTKGVRSAGGTYGSLSKRFDGKEEKPAEKVQVSTGDKDEDAKIQAILAQGAETWEQMQEDMSAGYRAPAARAARANKPSGSAVAGASQKYDFSLGPEKEPPVGYICYRCGQKGHWIQNCPENDDPAAAERKRFVRVTGIPRSFLKTVETPVGTEGSSGGAMLTADGGFVKAVPDQRQWQKQAAVKPRALTGADVRDQEPLEADLTCPLCKKLVWEAVRTPCCNTAFCEECVQTYLVDHDFECPHCESKVPSLDRLKPDEDLRKRSRIYVDHELQKNKDAKGENSDADVKEEGGNDKNSGDSEEGSLTPKEQSKNQILGADGQPLNSDLLDPHMIQNYLFGAKKMLLNPDLNAAARALLTTQMQTLQANLLQMQMMAMMNGMGMGVGLPLMGGQNNVGGGQNGIGMNGAIDNTMAMRGRPGFRGGFRGRGMATGQGFQRAPLGPAVQGGLGGGMMNRLNVPGKRGAEVEMGGEAKQPRNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5A0</accession>
    <name>A0ABR3C5A0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquinol-cytochrome c reductase subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616622.1">
        <property type="nucleotide sequence ID" value="XM_066754721.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987002"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8163" checksum="71BC715CFE3628BF" modified="2025-10-08" version="1">MPAYIRRTQLGFAGITPERLRYWGPTAAVWGVAAGAAVSFFLSEVPIFQKDVLIKVPVVGTYFKDTTPDSDKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5C0</accession>
    <name>A0ABR3C5C0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_100626</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617094.1">
        <property type="nucleotide sequence ID" value="XM_066755193.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987484"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="33"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="472"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0255817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="724" mass="81110" checksum="83EDE256542FB0AC" modified="2025-10-08" version="1">MSVRNIREAEGLLMNIHDPSKGPVLPKDGQRNVLITSALPYVNNVPHLGNIIGSTLSADVFARYNRTLNVPTLYICGTDEYGTATETKALEEGVTPYELCTKFHKLHTEIYEWFQISFDKWGRTSTPEHTEITQGIYKRLHDNGLFRLETSDQTYCEDDELFLADRFVEGTCPNCGYDDARGDQCDKCALTFSSPTQLINPRCKRNKAHTLSVRPSTHACYRLDLLQPRLVEWMQDARVKGKWGTNAVITDKGEIVEPRMLGEGLRPSAVTRDLKWGVEVPKVGDEEEDKAMEGKVIYVWFDAPIGYPSITATYTDKWEKWWKNPDNVELYQFMGKDNVYFHTVLFPATLLGTKEPWTMLHTISSTQYLNYEDTKFSKSRNIGVFGNNARETGQPPEVWRYYLLSQRPENSDSSFLWSKFIAANNNELLANLGNFVNRVVKFINAKLDSKVPGPEGFAGGEVIPRSDSPDFDFVTDVNTRLKEYREQMDDTKLRGGLATAMALSARGNQYLQENSLDNALLASNPERCAEVLLNAVNLIYILSVVFNPFMPNTSEGILRQLNAPARSLPTKFSIDILPGHVLGKAEYLFKKIDNVNGEQEKKWQRQYGGDAVVADQVVPPGPGGHPEGGKVPKAKDISAESKKAAHEARKAQLAKEKKAAQAAADAKKTPEEKELEAKVEAQGKKLAAIKKGLEEGDAEKEMSVAKSLKTELAELRKRLKGTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5F1</accession>
    <name>A0ABR3C5F1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100654</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617122.1">
        <property type="nucleotide sequence ID" value="XM_066755221.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987512"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="1181"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="300"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="455"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="678"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="764"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="939"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="736"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="767"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="783"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="822"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="948"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1070"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1097"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1111"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1138"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1149"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1289" mass="139256" checksum="B48CEAD7E4B1A07D" modified="2025-10-08" version="1">MPPLTQDYPTFTHYTSSLRDGLRQSASNSLVELEQAINSKGYDWLEGYMSQIMAHIPQAPIGELIKTPSKTQTVKRTRAATAAAKEKTQKIKGLNAQLVLSPSSRQTSRPALSPLQFGSRNANISNAASPSPIKSKPVKASTPSKSKAKRGRPKKAGPAMISDENASPKFENKKLYLSSAVDPEHPFSPSHQSKLGREKEHASSIKIEKAPKSKQIKAETIEKITEVPIDRQNMDADHDETPLQSAVDHSPAGEPHSLPTVGEIMDMGIDNVTGAEDTQLKEMIEVRPELDNANSADAVLTTPEENALDSAPKEEGTGDLNFGQPKEEAGEEARKEAAIEDIQGQESTINETAGITGSNQNSFEMKEGPVPRTEFSAKVSQASATESNGADTAVTSSTQPATVSQSPPAPFKASFMESSASSSTTALTSGAVPIPVRQVRSSWLSKALGTGTVPISNASGPAESNPAICKPFTAPSQQRPSAAMDFSGLRKSLLPIGGLKRKSGEGMGGQEEEDEGRRPDKFTKISSEPHDFQVSTTPVPMIRPKLPSKTPSFGTGSVNSNPASQSRSALPSGLIDDPHRPEISKVTKALDELREKTAKDLAKQKASSAGRPESGNVRAPKAKSTGAGFLRGLLNFGSVSEEEEAIRRARELEEEKIAEAELEKLMWNATKPVLDVESALDNPTADAVSASADPVPQQEGDNNAGRSTTPSLSPPPKLASLQPPQMQPQSVTTATNDEDEEMFDEESVLDEIIPAEIIEPLYINDKPQQPSSPAVAPPAVIDTSANPVEPSVSTTPVRARPSISLDRREKGQSKVSDINAMKMEKAKEQGKEHDYHGQGDTAIEKPDDKRKTNGKFPVAHEAQGDYPYDNNVTDETEINRELPSSIATSTDVLNISTSSQATSSTLNHASTMAAKALGVRPATGPVKSLQLAAAAAKKEQNAASRKAAMRDQADKRKELLAQKKAEEERLRADEERNAKIAELEEKRRLRAEHEKRKKEREARVAAIAKERAAKEEREMQAAKMKAEEEAARKRKLTVALNKSQSSGVPASKRLAGPSQSLAKGKESFRPTKTTSTHPLSQSTTEQQAPKAFRTAETAHSQSSTITLVKQTQRESQVERKPLGQPSRPSAMGNQATRQPQHQQNQIPQRSSSAAPQSWAQVQASLDEKALAQQSEDIVLPDIASEYSDPDEDTTRDFDRPAWAESPELRKALEAQAHINPDELFGPIKPLNMDELFKARAGKFRARTSSANWSRGDGLTRAEEVDYARRMGFTSLSYYDDAGGNGSHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5H4</accession>
    <name>A0ABR3C5H4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate hydratase</fullName>
            <shortName evidence="3">Cyanase</shortName>
            <ecNumber evidence="3">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cyn1</name>
        <name evidence="5" type="ORF">I308_100669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617137.1">
        <property type="nucleotide sequence ID" value="XM_066755236.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987527"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate lyase C-terminal" evidence="4">
        <location>
            <begin position="105"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="183" mass="20454" checksum="5F06A211A1A46F44" modified="2025-10-08" version="1">MFNLPYHCKALLTAKQERGLTFDDVAKAINKPEVWTTALFYGQATTDSNTAEAILKALGGEQHWADYNDKLETGQEKIDVKRVLNGLSGNGEENMGVKGMITRGATFEVPPKDPVLYRLYEVLVVYGYSYKALIYEKFGDGIMSAIDFRTSLERKKDPKGDRVVITLDGKFLPYSDPSAWGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5L4</accession>
    <name>A0ABR3C5L4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617190.1">
        <property type="nucleotide sequence ID" value="XM_066755289.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987582"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="74" mass="8044" checksum="E178AF14698F55D5" modified="2025-10-08" version="1">MVPKITSTSSMKTKHIKRASCRARSKIPLTPPSLVSPPLPPNIRSTAPLGGLPNTWGVLEYFSTELLELLCSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5X2</accession>
    <name>A0ABR3C5X2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617300.1">
        <property type="nucleotide sequence ID" value="XM_066755399.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987693"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="78"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="161"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="265"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0256023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="357" mass="37357" checksum="A97E1894AED1B0BC" modified="2025-10-08" version="1">MSASPSATAPPEASPTATPTTATTAKRPASPDNAEDSAKRPKQDQNKMADVDMQNEGSPKAAPTSEPTAPAKPDPGPQQISMRSLIVTQDASIIIGRGGAHVNEIREKSSARVTVSESIPGNPERILNVSGPLDAVAKAFGLIVRRINDEPFDVPSVPGSRAVTIKFIIPNSRMGSVIGKGGSKIKEIQEASGARLNASEAMLPGSTERVLSVSGVADAVHIAVYYIGTILLEYQDRYPANATGSYRQSQSRGPPPNSNAPPPPGMQTQQIFIPNALVGAIIGRGGSKINEIRSQSSCQIRVTDPGTTLPGGAAANPEERLVTITGYPDNINAAVALLYSRVEAERAKLVEQNAEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5X5</accession>
    <name>A0ABR3C5X5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pumilio domain-containing protein c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617151.1">
        <property type="nucleotide sequence ID" value="XM_066755250.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987542"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="424"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="581"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="734"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="797"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="833"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1093"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1154"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1101"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1255" mass="134211" checksum="E18894F3A3EBF2A4" modified="2025-10-08" version="1">MAQPPPAAPRSSLSPEKNPARQRDGRTPPPAPSAAYARRAREIIGDEMGVHAYKPVMDAEDAATDAPNGVSAGYRRARAGTMPSNLQVSRDATEQPAGATTATSPTPTNPAYARTSALSPAYPQQTTASRPALRHTASSAANLETPVASAPSRLRSGSLTLPGAGLGDAFGHGPFSNAWLSNPGLTTAATTPARSPLGQRIQQHEGAFSSYTSPSESAGSLGTDDLNFSTLDYLGLADVSDHLPPASMSELRSQTQRAIASSGPASRLRASTVSNFARPFRPSVTSIHSFAQEANPYENAQNEEEVLSRAIENLGVYEAPYMSNPQLANLYAPTNLFKDNHRQRASTIGALENPQRRGLNRSASYLASIPQSPIQNELAAFGAYGYVARSRDSSRAGRLSISSHTSRTGTPEDKGSSTPQVPTRSLWIGNLDVNATSSALLHVFAPYGAIESVRMLPEKTCAFVNFMDKVDAIRARDDVLNRLGGHVSALSETAPVRIGFGKIDSAPNGPSVSTVAPAPPGLVFTSGPTPLSTTPIAPMSSAPPPSAPGPPGAPVTIPSQTATNMISSPDQNDHTSALPTRALWIGSIPSTTSASTLLQIFSPFGPVESSRVLQNKCCGFVNFERLDSAVSARNALNGRDILGSDVGPIRIGFARVPTRSPTISTAHLGLPASPSDSPTKLGVALNTVLGATSVSTEQQMSVEGGGLENYRSPLVLDLVKQGVHEQVLEKGLAGENDEDNDIKAAADPRPHATYYTAIPSLPDRSMRRFDTGKLKDVRKKLDSGQCRQDEIDEITKDLMNDCAELSSDFIGNTIIQKLFERTSHALRIAMLERIAPHLATIGVHKNGTWAAQKIIECSSTDEERAIVVNNLRPFAPPLMCDSLGNYVCAGTLRFGEPFNHYVFDAMIDRMWDIAQNRFGARCMRTCLESPYTSLYQKKRISTSIILNSIPLATNPNGALLLTWLVDSSNLPGRYSLLANRFIPHIAHLCTHKLASLTVLRIITQTTEPQASTNLVQAIFTSTNDQTLVEILSDANNGNQVIGKIIAVNSIAEDLKKQMVEAVRRVLPNIKASTTPPYRMLLEAVGLPVPAGYVNDSPFGRNPNPHWQPNRQQQQQQPQQPQFGQTYYPYHQSVNDAGYQAVNGLDNLSPLLIPQTMPLGQMRGNPQPGKSPRTPTARQGRLSPGSMMSPASDPFNPFASPSVDLQYPSQGGLRMGSTLSQPPVTFEQQPAIGGLGMGGQGQGGGMMYYGQQSSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C664</accession>
    <name>A0ABR3C664_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome maturation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617103.1">
        <property type="nucleotide sequence ID" value="XM_066755202.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987493"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16888" checksum="21B93A822762842E" modified="2025-10-08" version="1">MSFRVVPPTAQTSTDPHVVSTQATVHPISGTHDTFRYGLKSAAQSVAAGTTSPLQARLEKWSQTQTQLQQGIQRSTFGFAVPMKQAMEVKLVSESLHNPLLEQSTLSGLPIGGSHNLSLEILQGRDESLDADEFMGGSQSMAEVLDVNGALERKRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHU4</accession>
    <name>A0ABR3BHU4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610772.1">
        <property type="nucleotide sequence ID" value="XM_066760947.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993375"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0240273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="678" mass="76136" checksum="0AAA46E0CFB7E827" modified="2025-10-08" version="1">MKPTTKLHIPINEKASSFFSSPYPPQQPSSSQLSPIPDSSPSSAAYTNSRSPLLPPSPKVLESGYPFPATAHANAGGRWARVRMALRQSVVPQGMLRRVLMLFMVLGLVVLVLHRSGTSLQLTETYSPDPTSHAPLTSTPHDSREIDIYSEPLPLDATLRERLDVWKNAPGGRGEVEGEVELGGFMAWNLEQCSTISEQHNTHMIQHSANMWASLNRTSLRQYRMELVDHMEGVLKRREHEKYGEGRGIVTVAGNADTLQRVKWSLQMLRSYGSELPVEIYHFPSEAPPADDPIRTELAELGARLVEAKGQTRDKGKNKSYHLKAIAVVQCPWQEVLYIDSDSIPTRDPAYMFDAPNYKRLGVWATPDYWKTSANNPIWAIMGVKCRNEWEMETGQMFVDKKRHLDVFLLVQYMLENHHFWFAFSDGDKDIFRWALLALRKRWAVPGRWVGAAALPSGTASGEFCAHTMLQHDSWGEPLFVHYNLLKQIPSGVGRGYSWGRTKQLPLFNTWPATASTARLDEPERKPEDEDKRGLGDVDCDMLADAGEDGRARGEAKEMVMRRAARERGVKVRYHGGVVSALCIDLEYIDPRPKERQEEDAARRAALSASAALISESLPESTSGGDGTSPESEEWVGVVEPDWSQSPIEVVHWRDDEHLKSFENTIYDFGFKPSGKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHV9</accession>
    <name>A0ABR3BHV9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106539</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610789.1">
        <property type="nucleotide sequence ID" value="XM_066760964.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993394"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="76"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="388"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="627" mass="69152" checksum="717CF4F216B8376C" modified="2025-10-08" version="1">MPPSASKQKRLAEKAAKAAEKGKTGSSKSSVTGASTPLTSVSDDPTDAAEQMKKLSLATDRSASGVLVSDPKGRDIKIDQYMLSFHGRLLIEGAEIALNYGQRYGLLGENGSGKSTFLQSIAERDIEIPDHIDIYLVSGAVEPSDVNALDYIVSSAREKVERLEKLAEDMSTADDVDELALDAIYEELEEMDPSTFEAKAGAILNGLGFSQQMMAKPTKDMSGGWRMRVALARALFIKPHVLLLDEPTSHLDLGAVVWLEAYLSTYNHILILTSHSADFMDTVCTNIMDLTSKKKLVYYGGNYTTYVRTKSENEVNQMKAYAKQQEEIAHIKKFIASAGTYANLVKQAKSKQKIIDKMEAAGLIEKVEQPRQLRFNFEDVKKLPPPIIAFSDVAFSYSGKKEDYLYQDLSFGIDMDSRIAIVGDNGTGKSTLLNLITGALQPVEGTINKHTQLKLAKYSQHSADQLPYDKSPVEHIASLYSEKFPDKDVQFWRQQIGRFGITGAHQTSPINQLSDGLRNRVVFAILAMEHPHIILLDEPTNHLDMGSIDALAAAIKEFEGGVVIVSHDFRLISQVAEDLWEVKDKKVINLTKQDISIVDYKKALAKRSQAQIEKAKLISKSATKGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI51</accession>
    <name>A0ABR3BI51_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610881.1">
        <property type="nucleotide sequence ID" value="XM_066761056.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993488"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="310" mass="34602" checksum="031EDEDF72FA8F6E" modified="2025-10-08" version="1">MGLFQSSDGIRFNPLRHSFSLLLTLISFILLMVVVFYNAPIDHVHSTLDGKVGLRMWLLTTDETSVSFPTWTIGTKRYYDAAEGEMPGNGIGLAAPASNEERGTNIGAVSDGGLHTYGFGIWGWCEWTSSRPMGDAVCTRKTAYKLPNDSDSSWDSIYELELPYAVTHVLSGSAIPILITPFVVLSYFIILCLAILFPGPYPPWPVPRKYPPEVKHYRTRCAWLLRDWRFNLCYFLAMLALGLSMIVTVLVGKGKVNNTGRGSLKAQPGTGFGAFFAAWACWVYAQMLCLWKNGLIMRREGKERTKYSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIU7</accession>
    <name>A0ABR3BIU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611119.1">
        <property type="nucleotide sequence ID" value="XM_066760847.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993273"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2289" mass="252449" checksum="799C5B9E4AE9437C" modified="2025-10-08" version="1">MLSVPEGNTNNDARRALGIRPGSQPPPQLKLDYTNFEEIPPFPTLDYPPSPRSPTTSRLPSSPAPPSPASPEPSRSFRRATLAGRHVLSAKKIEKISSSRGLYETQKLLLHLLDRLEQRETAPDILERAAISAREISGRSKTKNKGKALRLGHAIASAAGSSSSTGSSRVHRAVNPTVGVGSEDYEDHIVLDEGDWDTEASYNLVEQTRGLLVLADKQQLDLFADTGDTEVPVLDATPIKSKRRAGRFSSVSPSAAFAKGSSQAAISSPDTSFASTSTPNRTSTSTIPSISGPYLLERTLDVLQSLLSVDCLHRTHAFRPLCPPNALQAACLDIAAYLYQKGGVGTKVRLVGMVIDGFYGMGEGMGEKICEWLEGRMYDLLSRLARERGNVKESKGDDVEWTDPFSSQDSNASRNAALPTFAISSESSDSIPRKVSETPGWMRFSPTSPSFSLFHRDILGLLSIQSLRDASSTAVEIAALVPRILMAITSTIILTQSKLTTIYRVHRLLSLILNAKPDSSLDLLTIIAHAPPPSRRTAAEILATFYPNAAGHNTVARRLPSSSYIAQRMKWETGHFGILGEDETEEHHFIPWRVSPHDDPTADVVRCEVCESEIHGFGIKCTMCKEQRHLRCYDGSGKTRKGVYQYDVVTLSPTSTSSQLSYAKFCQSLPRLEEVLLSPPHGTACTHRKAGQHVLDLVHLFTLTLCGECHFPLWGVANQAYTCQNGCQIFFHSHCVDKMEGTGIGECRYGREVVVDEISGAGNNPFVITHDQFQNSFHRHYNGFLPSDDELKGRTFDEIGVIFGTIWIQHQLIKNGLSSGCLRVSSEDKKATSDPLGLKAILKTYEEVLQSHEQAISTATADFTHVTMLEKPLGTGYLFSEKFLGYCTALIRAPTTNSGKPSRDREHLGDDFLTPQGLLISPEGEEREKMNKCYETLPLGIIIQSLATDLSISDKFVATAFLNQLSLVGFIFISDTASLTSQYLVKRREIKLSFALPLLMDSSPNTELLVLAIEALLDDLDLTMNEQGLRLLATRAWPSLLCAPYALERLGKACVSWVLSEEDCLRDIIKKYASKHRRIPGVRPAPGAQKGSVDMYKQDRQRLRSLFVRPWLKALHDQDPALYAHIAYEQCKLVAANVAMEDLSGANEEQVASRMAGVAASKMASMGEADMLFSTIMELLTAWLEDLGPLVDHDVAYRALPRLLNHQPADSADIFALSLSTAQADPADLARVCRWMRVLSYSGVEIPWELLLSLIDLQARSPAFTFDGSVGGVSAEAKLDLVIAVNSNRAAIEPQTFANACSRLAVDVFSDVGRHGKMDPLELELVKRTMLLILQAYGVSVDEVAETTLSVGMSGAGQPSTSTAGKRQNLISNVRFPLNADMVVRAATLLERTSCPNELVLDFLWLLSAKADMVDDPVGFLHHTCSKLYEIIWPLIGLPVDRRSRTRVFLKLLSVNWTPLERIIHAQLESSPEARTQVRERLLTFVLELADTSVNYELSNWRAASVDLILLFFDVLLDPRNVIPDNIIILKTLQPTQLNAMSMCFEEHLVKSSDERRLVLLSKLSRLRMSVPQWAIISWTIVDELLAEEVASLTQFKGIHQPHTDSSLVDSQNVAYSLISLGLEMLAAGVSITWIAAQRFQQRVASACALPWFNPPVFTAVVLPGLREENCPGWQLRTLLDILMVTFFKQDVTRVELSTYSAVQKVADFVLISECSENRLFALQILQTAVVKVERDKIIRAVPPAFNTVAKVLIKELEAEYGDSAVIEQSQLFLRNIVKSFGRSGLYLQLFRNESESYDPSSPDNASLAKALQILQSEQEREMLPQTGLFDNVFHDLLDVTKRPRRQVIHIIEAFARFATSFEVHLTEEAAQDFGTFVNRLSKLIAEWSFDFDPNPVLQSCAKILDLTPSASLIPLLSQVSTILNQCMGHFTIKRATVIRLLESGERASRKAQSENQIRTVLFELSGAAINGLAVTPESLHILLKVLTSDAFSRPTPGSQVSSEQIRMLSDASPGCVQLLLKGHPTLQSNLMSAEIVLGILNEAGMVLCQAEMVVPGAISRNLTQLTLDPASSQVNFFLYLLLSSLDLRMGRARSRLLSLYPLLSRATSLCLRAASDYITLQDIEGHGTSLISLAFTVIRLALLAVRDGPVSNEDGEREADDEDAVGILWTRIWPEWIRLFRLSFESSCVNGALRTVTHSVFLDLLIFLGIIQSPILMRHTQSLSATLVMLVQYQEISGVTPSSKLQKATQIMEKVGTLSAGGVADKVGMVESLKADLLATERIKALNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJE4</accession>
    <name>A0ABR3BJE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_106083</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611291.1">
        <property type="nucleotide sequence ID" value="XM_066760530.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992938"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0241909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="179" mass="20148" checksum="DF2CD8B1A9233F8E" modified="2025-10-08" version="1">MFSLRPLFRSSQLTTAARRTLHYSAPALNASTRPDSPVTPVPTVQDGTVPTEYELANGPQADLVSGAPDELLHRPVRIFRPTKNTMQSAKGKTKRWMIDFDVLQGAGRWENRLIGWASSADYVQGTTLAFRSKEDAIYFAEKQGWPYKVDEPKKIEVPPKSYANNYVHVPGKLRIHHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJI0</accession>
    <name>A0ABR3BJI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611332.1">
        <property type="nucleotide sequence ID" value="XM_066760571.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992979"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0241950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="144" mass="15688" checksum="18FE0DC96AB20A0F" modified="2025-10-08" version="1">MSLLRSARVLRLPRPVSLARSYATPPTPSTAPLPEKQPDASSPAYLQQSPNVPTTWSTSQNPKPHAYDNARFEQTAWEFQPNEPSAMGMVAEYPVRLVQGRKAACDGGGGALGHPKIFINLDKPGPKVCGYCGIRFEQAHDAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJS4</accession>
    <name>A0ABR3BJS4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611421.1">
        <property type="nucleotide sequence ID" value="XM_066760660.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993082"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0242039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="412" mass="45975" checksum="0BB9605E6CAA7C94" modified="2025-10-08" version="1">MSVPELSPAVIQELLPHLLPPSPLPQPLLSKSLLQRLTYLPPSPSDLDAHLSPFPSSEEQPISTRLRELSRGHRWSEKQYVREGEDIFARMIVEREEGGEGVEVWFEWEGGSEGSEGRGWVYHSARLPSISEHNWVASPALLPPLISAVPESPYDEADNPYAAPAGYWSAFDDEPLSDTKEPGYESDHIGAEDAYWAQYSRPATAPITPGTHTPGLYHAHSESNAHNVPHPHAHNGLASYFQKTGPPVSQERLKDIDETAVKLHESLTKLGLDPQNGGLTLASLSLEPKGIWRETGDDVRAKVAGKIGSGLNDIWRQFVGESEGEEKEEKAMEWLRLARPVVDPLASPIAINRNLKGEKVVAKLEVLKDMYELLNEAEEEQGFWRMVEGVIRKSSEEEGMEDEVTRQQMYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK80</accession>
    <name>A0ABR3BK80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611570.1">
        <property type="nucleotide sequence ID" value="XM_066760266.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992672"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19062" checksum="BA4B25152D413F4D" modified="2025-10-08" version="1">MEIDSHIGCAMSGLTADARTMVEHARVTSQMHAFTYDEPIGVESCTQAVCDLALRFGESVEDDDALMSRPFGVALLIAGIDEKGPQLYHTDPSGTFVRYEAKAIGSGSEAAQQGLQDAYHKQMTLAEAQSLALKVLKQVMEEKLDENNVQLAQVTKEKGFEILGEQALKGVIETLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKD8</accession>
    <name>A0ABR3BKD8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611260.1">
        <property type="nucleotide sequence ID" value="XM_066760499.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992907"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0241878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="140" mass="15424" checksum="64E5CA6EDFD24729" modified="2025-10-08" version="1">MPFRKTPCLSKPIIQFKLPFSSFSYPPCTPPERGTPAQTPGLAMSQTSWPRAMAVSFMIVTPPGQYSTQFPSLYPTEYPAEAAIDESSESDDQSVEDLMSLVTENEDGQERRWDGKGQEPLEKDAICPGAPKLSPIDLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKP6</accession>
    <name>A0ABR3BKP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105989</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611742.1">
        <property type="nucleotide sequence ID" value="XM_066760438.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992844"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03775">
        <property type="entry name" value="MATH_Ubp21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="8">
        <location>
            <begin position="49"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="209"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0242360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1113" mass="127946" checksum="E513080ABD9742E5" modified="2025-10-08" version="1">MQQPVNDVQDIILDESPAPMEVDDIPNVHDYEGYAAKCMPDLGLEIEDFQYQTWRIEHWSQQPKRIVGPEFSCGGHKWRILLFPQGNANGQPNDMVSVYLDYANPKTAPEGWHACAQFCLAISNPWDPTIQTSSHAHHRFVAEECDWGFTRFVDLRKLYTADPANGKNRPTIENDEVEITAFVRVLKDPTGVLWHNFVNYDSKKETGHVGLKNQGATCYMNSLLQSLFCTNYFRKAVYQIPTEDDIPSESLALALQRVFYHLQTSNQPVGTTELTKSFGWKSLDSFMQHDVQEFSRILQDKLEIKMKGTPAEGAIPKLFKGQMKNYIKCIDVDFESSVIEDFYDIQLTIKGLKDLRASFKEYVSVETLDGENKYQAEGHGLQAARKGVIFKSFPPVLHLQLRRFEYDVEKDALVKINDRHEFPFEIDLGEFLDESADRSQSHVYKLHGVLVHSGDLHGGHYFALIKPEKDGRWYKFDDDRVTPVTDKEVLEDNYGGDMLNGLVPPHQRTQARTLKKFTNAYMLVYVRETELDTVLAPFTESDTPPHLKARLDHEREQLEAKKREKDEQHLYLTAKVITDEIFSKHQGFDLASFEDKNIPATDLPTFRVLKNESYPTFKSRIASHFKIPERDFRLWVLVNRQNKTTRPDVPIHENDNTQTMESIRNSMAARASDLKLYLDYNPDHAKFDELHAEGKEAPIMIFLKWFDCSRQTLLGQGKVFVDKYQKVSDLLGIIQERMGWPSSTPIKLYEEIKAGMIEGMKLKQSFIQNEIQDGDIICYQVELPEKEIADLEAQSLYSSVPQFYDFLQNRILVHFKPRYEDRAASVPEFDLMLSKKMTYDVMAHRVGEFLKHDPLKLRFTSAHNQNGAPKAIVKRSLNQSVADITQTSYYNQHAHICIYYELLDISIIELETKKSLKVVWTGRHNKEEATHSFLLPKTCTFNDVADNMSKLVKLEPNGSGKIRIFDVSPSGRSQREHTGSEMIGNLPESAELFAEEIPVEELQAGEGTKIVNVFHYSRDPSRTHGVPCKFVLHEGEPFSETKARLQERIGVSEKEFAKYKFSLVTSTVFKQPSIVEENDIIYDHKWAPDDALGLDHIDRRPNKANIEKGIVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKQ8</accession>
    <name>A0ABR3BKQ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611751.1">
        <property type="nucleotide sequence ID" value="XM_066760447.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992853"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="483" mass="53612" checksum="56CAE0DC2230AA55" modified="2025-10-08" version="1">MSSPIHKYLFSPPPSPPSRGPQSSLNPNRGLTTLKSLLLPSEFIPQSSLDHVGSPPSLKTRSPHTPQQGRFTFDNSAYPFSGRGRRGNGYYTARDLESIPESSILSPSQQVSDKKLQLAPPINIVSPSASHSRSFQSALTVPKPILRLFFLVCIIFTTAAILIFVPSARPPSLFPDSIAEQTAFVLEDHYVDVDVKINVNALGWKGMGEEREYEPPLMKAAWMLKGVRSKKETEVNKDVQEVKEVKKAKEIVEVRTQQLHAAPPPKATRPALRPRPIPASHELLALQSYILASQYNVLSENVDTSKPLDANTILGIGASERKFGGVAGSAAKKGKEREEEEAWLKDIESEWDGEVVVWFGGNGQKQLPHDVIDIITSSHSSNRHITYIPLYSRPDREIILSILARLGLPADSPIIMIDNEPILGDLETLEELRLSGELERRLSKIGWKKTSPQEERRGKKLKMAVIKKKENGMIEEVKKLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKU7</accession>
    <name>A0ABR3BKU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105382</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611783.1">
        <property type="nucleotide sequence ID" value="XM_066759837.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992237"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="741"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="774"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="413"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0243416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="812" mass="87446" checksum="4152BC79265BE79F" modified="2025-10-08" version="1">MPPKQPPEKSSSPSMGGAEPSNNDNGNAVKPRTISVSRNSPSVAASGTPPVPNIPSRTSMSSAGAARSFGGSFRPASSVTGTENSKSRRQSVSKEKVIPKDSSDNLIGNKTVPQTQATSSALTAALGSSPRPQDLSRQDSSSLSRPSVSRGDSDISTVRNGAASASAPKDRDKAGESSFSNLADVPDEEKARVLRRHLVSADERGASSPTPMGQSPAGSGVNVGSTPTTAEFEDVPGESGINGYGSIDAHPRDDSDQFPIPYDAPGGDVTHDLYKWQHDHRTRPVRSASFSHVPVDRETILDPHLARIKEPGGFRRSFLANRAQEQGLEAPTMVRNVVDFLYLYGHFAGEDLNEDEDVLEEDEEAAAYARRQFPAEGEEAEQIARRERAPLLGSTRRSMSRHRRTKSGHNQGTASITQAVLMLLKGFVGTGILFMGKAFFNGGILFSSIVMLAIAGISLWSFLLLVQAYMKVPGSFGDIGGELYGNNMRLIILTSITVSQIGFVAAYSIFIAENLQAFIMAVSNCRTFIPVKYLIFAQLIVFMPLSMIRNLAKLSGTALIADAFILIGIIYIGGNEISVLSKNGIADVALFNKQSFPLLIGTAVFAFEGIGLVIPITESMREPQKFPRVLSGVMFCVAILFAGAGVMSYATYGSDIQTVVIVNLPQDDKFVQAVQFLYSVAILLSSPLQLFPAVRIMENGLFSKSGKHNPSVKWQKNVFRACTVVFCSLLSWAGSSELDKFVALIGSFACIPLCFIYPPMLHLKACARTPKARIMDWMLIVFGTIVGAYTTVQTLRSLFIPRAEGPKFGACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKW8</accession>
    <name>A0ABR3BKW8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">[histone H3]-trimethyl-L-lysine(4) demethylase</fullName>
            <ecNumber evidence="4">1.14.11.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I308_105400</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 2-oxoglutarate + 3 O2 = L-lysyl(4)-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2</text>
            <dbReference type="Rhea" id="RHEA:60208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.67" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611801.1">
        <property type="nucleotide sequence ID" value="XM_066759855.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992255"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15525">
        <property type="entry name" value="PHD_UHRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048615">
        <property type="entry name" value="KDM5_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21323">
        <property type="entry name" value="KDM5_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="17">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="16">
        <location>
            <begin position="242"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="485"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="18">
        <location>
            <begin position="650"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="1523"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="122"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="370"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="448"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="567"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1012"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1020"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL0243434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1856" mass="207343" checksum="B56AB06AE911123A" modified="2025-10-08" version="1">MLPSTQQTTAAGPLPATPNKLSLRRRHSSSKQDTPPNLDGPLRFNPSASESARRGKPTFFSSMHFSQALPQPIPSMAPDERRPEHQRSQRKSKVEALTKIDRSGTPIQLDAGPAATSFAPRMVQKSTPPPPAPHYLRNPLHRPKVVNPPFSIDSVRTKAPRHPHPRTEPRLFGLEDCPTFYPTPEEFKDPMAYIESISQQGKKYGMCKVVPPEGWHMPFRLETETFRFKARLQRLNQLEAASRAKLNFLEQLSMYHMQQGDSKIHIPLIDRQPLDLWKLRREVNRSGGNLELDRTKGWWKITEVLGHKPSWTPHVRAAYMNIVLPFDNWAVRAKSASVSPLTKLNPGSISSPSKPPPLFINDTFSASPIKQGQGISRASTASRRPTIRMRPNGMHFVSPPDKGQPPSKRASVSGDGVLADVIEVNQPGSLSTAPSATASTPTTLRINVPGFLDREGSDSELSDEDSVLSSPSIRKTPFEPEYQKGEVCEICKGEHDPGKILLCDGCDRGFHIYCLDPPLASVPTNEEWYCTSCLLSQGEDFGFEEGDEHSVASFQARDAAFSHAWWNRHNPHNSPRPSVNGAQPTNNDDGERMEPRPFGKVTVSEDDVEREFWRLTESSLDTVDVEYGADIHSTSHGSAGPTPETHPLDPYSRDPWNLNNMPILPDSLLRYIKSDISGMTVPWIYIGMMFSAFCWHNEDHYTYSINYMYWGETKTWYGIPGSDAEKFEAAIKSEAPDLFEQQPGLLFQLITMMNPGRLSDAGVKVVACDQRPNEFVITFPKAYHCGFNHGINMNEAVNFALPDWLPDGKDSVRRYREHNKAPVFSHNELLITITLFSQTIRTALWLKDALIEMVEEESARREALRAKYPKLVENLIEEDCPEDQYQCAICKAFCYLAQVTCSCTSQVSCLSHADRLCTCGKPRKVLRMRYSEAQLEDIRDIVVHRAALPEQWRVRFFSLMESPRPQLKSMRTLVSEGERIAHPIPDLGPLKRFVDVATSLIQQIMAITTRKSVGRRKKASRGDGNRKGKRTRAERDDEEDDGIDRSPGVLSDLLKQADRLAFDAPELPQLRQLMLAIEGFRTEASSLLTTPEDQVDRQRCKNALILGQSFGLNFPELSPLEKLVQRQEWFRQLEEEVDDANMEYDDVVAFLEESLECQIPQDHAMVKELSVRERKGKQWIESVEKLLASSQITLGGISSLIEARQHVPVSTDILRRLESLRKSAISWQTSARNALATHGSPVAASRLCKNVAAASKPLSNVVIPEIRQLQAELKHHALWREEASKVLGVPVARLASTIDYIRSEFENSLAPDDDALNDQRVCFCRSSPADNMVICNVCRHSYHPRCVDVSLRHVPEEFKCAICQRLPNDDGPSVDAFIGLISPQRWNFLINPSEFEPAQYIASAAMRYAPQALRLADPFSLSHPCRDLELLRHTIRKIYTLPLVFDSYNSQTNERCVFVNWLFRRMQDAVRMKTKQVSVLDRHSLTLAAGQFTSANSENGTPSGRAKPRRRARIILAESHPHEFYCLCGMSPAGENTAAQVECPKCGQGYHAVCVKVAEELGGKSVWRCPCCTVRDGRHYQKDVEVRVQLRSHRGTDQFLDYRTIINDFAERLVVVTRPTSANAITLECIDFVPAHIPDNVKTMEGGGSSLNRIKKRKSAVVDGVFRNEQAASNSVAHNLIAMTAKCSMDTPSTILGEIPTQIISSGTNGSSVAMSTLSDIQAKSDAASRSIYTSDESNANTSVLALAPTIQNRSTFDMHSNVSPRSCFSSTPVATRASTTPVIRESSVVPSATTMCGGGREAAVIRKSIHDDNINSHRGSEGGNSCPDMGESIAVEEAVTFGRHVVDEDVIMENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKW9</accession>
    <name>A0ABR3BKW9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_106034</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611244.1">
        <property type="nucleotide sequence ID" value="XM_066760483.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992889"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0241862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14456" checksum="D0F38D4E9578AC8C" modified="2025-10-08" version="1">MFRASRVALSALKPLKASTNLTGLAVHPDPLPALTSIYTSTLSSLSQLPAASVYRQATEALTKHRLAIVEKAQGDIEKAEKELGSIVEIVIQEAKSEEGLVVKMKDWKSWEGLVEEPHPGQWRYFEPLSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKZ5</accession>
    <name>A0ABR3BKZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611828.1">
        <property type="nucleotide sequence ID" value="XM_066759882.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992282"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="329" mass="37083" checksum="A2B6D75C3A260C4F" modified="2025-10-08" version="1">MWAQSLLYRYEIPLAVAGVVLVRWLPALISPRPAVPAREPPRPIPRAAKCLLLVTSLYHLYRLVFPPYDLFIHNNLDILAPNTLLRDALGDYSPLQDLLLTRLKVLDNRYLYARLGHGPMLECLWCTHALDYFLFALPCILLPYLCEALVLGVLGWRVVGGPWAERRTERWRGIVAWTLVGAAVAEMGVKWGWEVVAVQGDCAHVAPAIHTIRSLFLLLLPVLYILLPVASPSPSPSPSASAIMPYLTSLQSTRHYTSVTRAAIRQSPQLRTAVQAINKREGEHADEARRDEAVWDRAREAGLDEDGIRRQVQVMLQNGWERLMRLGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLH0</accession>
    <name>A0ABR3BLH0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611665.1">
        <property type="nucleotide sequence ID" value="XM_066760361.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992767"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE 6.6KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10004" checksum="0466F97E40C9ACF7" modified="2025-10-08" version="1">MAGGHGHFEPVKLDPAIERWAQMRENVYQHFRFTPQKTRQVFTYALLVPALVAGIASTYNTKYDWAGKQKGSSLLANTPAKPLPESDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLH1</accession>
    <name>A0ABR3BLH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RalA-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612006.1">
        <property type="nucleotide sequence ID" value="XM_066760060.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992461"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13277">
        <property type="entry name" value="PH_Bem3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="400"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="526"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="872"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="660"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="796"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1102"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="720"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="809"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1117"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1142"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1152" mass="125555" checksum="0DC00D8B315431C1" modified="2025-10-08" version="1">MSSSASSLPPHLNLPSAYPHNSPKSHSRASPTNSPQTGTSPRLSPRGSTGMLDFEGVIRLHGGDLKKALESVVSERNKLLAQNTQLWKLIEKQRSQCAQFASDNDRLRQDRERANSRLTAAGLEPVGSFRKLNSSSSATGLGIRADVPQIRRDHSDREDVPVIAEKEERKGLASPAEVQPTGLLPSAILDRNLRKESQIGVPPDPSSFMPFADSPQSTSHSTHSTHSLPTPFHSAEPSPQLATSPRMAGREDGGVIPPPSSKALAASVAASSPLTQSLARPTVPQPAAGEHSLEYIEKLPSPTPVSVSGPLQSAPQLVRSETMSRSFSVSEATLVSSSTLDKAPRPSIDSSVSIPPTHNTTPRQSIDQTPQPKRQQSYSTERPQPPTLSTRPLSPSLLPHARITIPSSTIFPNSSGREVLCFIVEITIRSPNAQPITWNVAKLFSAFIDLDAKIKVTANKSRKEWKQIVAPLPESKSWKDFAPSKIDQRKTALEAYLQSLLVAPFSDKSDLCHFLSTNPVQAKRNDARKEGYLTKKGKNFGGWKTRYFVLNGPVMEYYESRGGNHLGSIVITNAQIGRQNRSVDSSDERHLRHAFLIIEAGKKGTTHRHVLCAESDTERDRWVDILVKHVEPEAMPSPQPLPTAAVVPIPTALEAPVAPAPQSSVVPANTTATNQNQVVPGLRRKSSQLRKQSKDAIVTSSGPLSSMAKDSKFIDAPSPSIYNSKQSHRPTQNQSRVAYSPTQSFTPQTVQSPIEEHATSQQMLPRKAPGPVQSHRQPWGSDSCIVQGISSSTNVPLLTSAPTPRVNERQSVIPSRPSVSLSSHNFLNTPSTLSLGVTSPIVEKERDKKAKSRGFWGFGRSTDKVTKPVFGVPLTDSLAVANIGDLPAIVFRCIEYLEGKKAEDEEGIYRLSGSSAVIKGLKEKFDDQGDIKLLAADEHWDPHAIAGLLKTFLRDLPTSLLTRELHTQFLTVTDIVEPSERIAELARLVSELPRPNYALLRALVAHLILIVQNSARNKMTLRNIGIVFSPTLGIPAGIFSEMITNFGPIFDDEIETLETRAEQDSGTRSAQFENADETMKRKRNSMLYQAGEADEMLGLSERHLNGTNDDSQSVSSSDDHASEYHSSDINHSNTVSVPVGGHQERAAIQKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLP9</accession>
    <name>A0ABR3BLP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleolar protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106491</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611190.1">
        <property type="nucleotide sequence ID" value="XM_066760918.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993346"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="386"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="386"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="6">
        <location>
            <begin position="389"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="438"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="70752" checksum="1D1DA9BDF96FBF68" modified="2025-10-08" version="1">MEGIELGIQDLDRSYQIDTQTPLSDNDKDHQEEPDQPIKRKRTKEEKERRRSEKKAKKEKRRWEAAQVAQARAQSQSQSPIEVEAEVAEEPIDYDAVEQAVEDAPVNDGSKTRKEKKHKKDKSKGKEKEKGVGENQEEEDREAIAASAVATLAQALVSSESDKVVPPVDQVQTPSRPTAVASSSATPRTGPIQYGSIKTKKGPLESSPALPASSLMPAPPATQLIPVTPLTAASAGVSSTAMINSLKHPKSSNSVPQAMRNTRKGEDTKESDAQLRLRFRDPRAQEEWLASTSIGKTELLRLEREGILSYKKGKFTEDEKLSIKKALENYQKIHRMSSFDLVELVMTKTLQATDKETVREFWKDIAASVPGRPILNVQPFVRRMLDPKAHKGRWTPEEDELLLRAYAQHPREWTKISSIVDRTEVDCRDRYLKELVNRDTRTAGRWTKEEEDKLEEVVDRVAKGLRAEQANGEERENSGEERAELVEPSDVPWDIVSKEMGNTRSMTQCRIKYRDAIWPRKLGLGKDDHVGRTLKVLTRLRNLNYESEKHISWSQVRETLEKYSLKEIRNSYTNLKKSVTSDPHVASLMYPELIKVMYDKAVMQRGRKVRADQRDYPRKIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLZ6</accession>
    <name>A0ABR3BLZ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612188.1">
        <property type="nucleotide sequence ID" value="XM_066759541.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991939"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="319" mass="35144" checksum="EBDE60A47DED0057" modified="2025-10-08" version="1">MRESPLGGRAANIRPFEKFTPFGSSNLIRSNSGPMSLEQLHPAGRILNLEPPCASHQETDEEIEWLRGAWRSELDPDEVFDSDDFDTWEEETFHSHTEVDGQCCPIALPDSVDLKLAPPNSTMTTPTLLEHNFSSLLSSLSPPDFETSTNEKISFPILIPSGEIQYMVLEEELQFAEAEEASWGCEGPSFAPSSMGSRASSFSSNDHAISGNKRRSADSLNDFGLMSSSPCSFGFPTLNGTSLAFSIDAQEEESVSEVTCGMIKFMLDSFTNPGPRPEAVNPLLECVSPRDTTSFMHSQNTFWSTSGLRKEEEIHQISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BME9</accession>
    <name>A0ABR3BME9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612299.1">
        <property type="nucleotide sequence ID" value="XM_066759652.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992051"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="359" mass="38653" checksum="CAFCBDE2E2CAEE3C" modified="2025-10-08" version="1">MDSATSNSTNTLLESMAGGQTAIYPTGCSYDRNISGYLSCAKSRISTITLIGVGTGITVGVLAIAFGCIWLARKSRRKVSSVVDRDDDEEESSKQTVKQDMEKGRRSAGKLSGTLNNEDIIPVKSREDNPFVLQASQRINKTTPRTAEIDRTDSFASEMDILSKTEQPANSNRATVYSPDHSQPAISYLSSSIRSQRLASDTVGSRNLFPSNSSPNPRHIQLRNESWPTRASAASTTGFQPLPSGIKRTTRSIPLRGVVSSASRPVSTVSFVQRRTSITKTNVPLVPIPAQLAPSSPTSIHYRSFLTRTESDASSPSQMAVPVTVSSNSVPSNPNTTAPLNIRKSGVQNATERSCAFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMJ7</accession>
    <name>A0ABR3BMJ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612380.1">
        <property type="nucleotide sequence ID" value="XM_066759733.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992132"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0244013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="420" mass="47830" checksum="70A0B9F705960311" modified="2025-10-08" version="1">MFFSNYHISKSKCSSFWGRDDMKTSFVNRHMSSFESALSTDAGVKDGQSVEHEHQLPIAMPAQPPEQMMPGGFPNNFPHGSPEYPDQYFYQDQQLPPGDHNSFTSNTSPAHGDDNIGAQVQQESQPSFRRDGSNSPGINQHPSTLNSQHQLLPPQIQDHYPPSQAPQHQWPPPDSHYYHHTPHQVYCPRKDAAPRLLTKNYEEHDEDRSYHPQRHARKYKGRKEPERPQQIQIITQGQDNGLISTKIADQMQMMMMNQMMMQQMQSQQMQAAQMAAMTQQTFQSLQSYGNNNNQNNNQNNRRDPRKRRRKSEPAVNIQTIQYMSRRKKLPRTKVIQVASHQGPEIAVLQPPPAVPPVPPVIAPPPTAGYVDTMALDNWQEATIILCFTAIGLIYLICSRANNKDKGKETKPDLAKKHLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMP5</accession>
    <name>A0ABR3BMP5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612422.1">
        <property type="nucleotide sequence ID" value="XM_066759775.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992174"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="362"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0244055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="674" mass="72997" checksum="63F99AC1C59F56EA" modified="2025-10-08" version="1">MDHSKGPPTRPINTPATIFHLPTLAKLSQQQPPPAPPLSSNGIDNTASVMGLVARGGKEAWRRSLNALWTSESRPKDDLSSRSSRRASVDSMSSTGSKAKSLLRAQSVDTSSILYPTLTVHPAPVSQNILVISLAHVSSAPPTLSNDELFQIVLRRLEPWVGEEGEGGYVLIILSAEGPPEKTTAFDDQHKEGARKLPGAAWWIWKWKRLPRKYRKNVKRFYIIHPSYFTRSLLPFIVPLLSPKSYSKLYPVPSLLTLYYQYGVSLKGIDITLPVLEAESQALKDDPNLLSFALTLSQAPLGEDSRPMLKRSSSGQNSSHWGFQALSSVVDTAASYVGLSRGSFSDPAEGRRAVASEGYWKRDLTALVDECGGKVPPLLLALGRVILSAGIGTEGIFRKAPKSRHLEPLLALLSLPLKDQGNLSWLQLAHADPLLPPKILCKFLSELASPILPFELYDVIRSIVKPSDIKERLFPHLPPSHILILQYVTYVLHRLTAFEDSTKMNALNLAIVVAPTLISGPDPLDDASMCLAPGKKLPLAMLVAAGKASEERVKGREVETSGQGTVVGMLEMCIREYHCVSGDPDPERMVCPVSPAGVAAAVSRAEAGEDRTVGDRESYPKGGKRRSGSIKTSFLGALFSGSGGNKESSGKEEVVDVRESVVAGLSIGSNSLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN37</accession>
    <name>A0ABR3BN37_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612560.1">
        <property type="nucleotide sequence ID" value="XM_066759073.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991463"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045441317" description="Cell wall protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="24529" checksum="979CCC7DB7ACFDB0" modified="2025-10-08" version="1">MIPIKHTIPFGLLSCLALLGSVKADGSTSNTSWPEWVTNDYDCVIGCLSGFNDTITYIPQDSLAQQAFDCTSSTCKGDVTGNYYQTLYYIQLFYATGSIYEYSDSAPDGYKHATFTDSTDTTSDPTVSGQSGDDNTIDPTNTSEADFTAATDSVKTTGSADGGDGGSSTDTAAVAVDTVSGSEPSSTKSTSSHTGTSLASSSVAPDISESGAFKVIGGGVGQSVLGAIGALVLGGVWVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNC3</accession>
    <name>A0ABR3BNC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612653.1">
        <property type="nucleotide sequence ID" value="XM_066759166.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991557"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="716"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="808"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="908"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="767"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="845"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="908"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0245569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1226" mass="133260" checksum="C6351C7F740FE4D2" modified="2025-10-08" version="1">MNRFTNAFSAAIPASNSSDASSLYPRDSPVAYSLLEPVFPSSQSLKAAGDDRHPKAIYDDPRSPYDSAASPSESLLGPTTTSTIPQVPTFTRPSRPAFLRHLTDDGPRSQASTPRIRSESRERDMSVRVNLMAAAATTTTRRGWGMSSATGTTRMNRMADGPDGKYAVGGGQYLRVFQVSDASSGSSTPMIQEEFKERTLLAKGRGGATISEVVNLWKSNWPVGKGVNDVDWGVAAWDHKLVTAAPSGNFMLFDVEKGRLDKELSSGSFRPLNCAQFCHQPSYCHMVLIGGTDGNIKLLDLRSSDPPSRRPLRHSSAITSLCFSPTDASSFVIGLEDGTIKRYDWRMAGKHLGTVYGAHGSKAVMDLKWKPADDSVGGGGAGWLASAGANKIVQIWDMNQSWEKAPSATHSLHTAHPVRRIAWRPDHPTELLVIPLTQPLSSSNSLDPATPSSQPPPPRSSASSSSQSALLSASSKFSIPMTRDETTMDNDSAHLEIWHVRRHYIAKYSIPSQDGVAVDASWRGHAGSGLVVTFQNGGFAQLDIPRKLNSGLIPLPLDQIPRQIAGWSAKGVLYFAIDKFKPGEVPFDDLKPEYANHYERLGRPTHSISDPPYIPLQTIGSLALPDNDPSEFAFLANWYRLEGGTPANLCAWNRNVAKWCGREDDARLWGFVKGLFEEFMPQEEEELIKEGSFAQDDVWGRAGAAAVAGNTAGKALSLTTPPDVSPKSRHAQPALDEREKKTMYRGIPLERITPPASPTSNPPESSEYSETDSDSDMVYSDEESESAAKPRSKFVSFVEPDMSSLKLDLSATRRHSSFSSQEEDEGSSPVIEKKQQGETSPIAIANTNPSMSGSVSLPNSASKKNNLSKMAFTPRQHQHHPHHPHLLVSSSDWPDPYGIIPDQVLTSGTMTGVTSTPGTSRTSTQSSPAPAFGRNIKEFPRAGTTGLAGHEIGSGVVEAPLAGRGSTEVGVVLVDGNGPVKGGVTSRVGSGQGKEMRGREEKFEKKEWEEYRKRRVETLITWWDGCVENGEMQLATTIALIASPLVTFPPFQVERLAHAYVELLERHRLPMFAAYIRRFSGIPSLEITPQDEGLTHTYFCERCGKSTGSLEDIEVKGKIFWWCKKCRAGARGCAICRKVIKGLWMGCRKCGHGGHQACMRLYHSQAPLIPVPSHTSHAPPNTSSSAYNQNAVSNVNVIEAEGRFALCPTGCGCRCRRIGAANTGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNS0</accession>
    <name>A0ABR3BNS0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arf/Sar family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612779.1">
        <property type="nucleotide sequence ID" value="XM_066759292.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991686"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04153">
        <property type="entry name" value="Arl5_Arl8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0245695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="19820" checksum="ADFE9ED2676BB046" modified="2025-10-08" version="1">MGVTFSSLWSRLFARKETKVLLIGLDNAGKSTILYRITTGAVVASAPTVGSNHEIYDYKGVRFGLIDIGGQTSLRSSWNQYFNGTEAVILVIDSCDGPRLGLVKQELMKIVADESLSTALLLVLANKQDLPVSQGRLTPAQVSEALGLTDLREREWQIMGCSALTGAGLMEGMDWLVTKLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNU0</accession>
    <name>A0ABR3BNU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104879</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612827.1">
        <property type="nucleotide sequence ID" value="XM_066759340.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991735"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="67"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0245743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="563" mass="62445" checksum="C125E2E82C23EDDD" modified="2025-10-08" version="1">MAGEDPAVTAFVEDVPPHPSRKVSEDGPLFQDKEISAMYANAAAATEKEQSMTLLEGLRLYPKAIAWSVLISSCCAMEGYDISLLGNFYAFAPFNRKFGVELDDGTWQVPARWQTGLSNGAQCGQIIGLIVNGIFTERYGYRKVLMASLIWLAAVITLFFCAPNIKVLLAGEILAGIPWGVFQSIAISYASDVCPIALRGYLTCYANFCWGWGQLIGIGVIRAMFTRDDQWAYRIPYAVQWVWPPLILAGVIFAPESPWWLIRHGRIEEAKKSLRRLASPKRNASYDVDETADMIRHTTELEKDITSGASYWDCFKGVDLRRTEIVCAIWSMQNLSGNTFSNYSTYFFEQAGLTGTIPYDFAMGQYGINMVGVFGAWGLMALGLGRRKLILIGTSGLCIVLLVMGFMGLIPDSKQREAGLATGSLMLVWAIFYQCTVGTVAYSLVGEIASRRLSIKTVALGRAAYNVVAIICNVLTPYMINPTAWNWGNYAGFFWAGSCFLCLVYAYFRVPEPSGRTYAELDLLFERKISARKFASTHVNAFDVALHHQVGEDKVLSDHVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNV6</accession>
    <name>A0ABR3BNV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="9">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_104577</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="9"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612535.1">
        <property type="nucleotide sequence ID" value="XM_066759048.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991433"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="14">
        <location>
            <begin position="113"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="13">
        <location>
            <begin position="261"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="522"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="622"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="704"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="11">
        <location>
            <begin position="751"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="12">
        <location>
            <begin position="1117"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1098"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0245451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1206" mass="133848" checksum="D56795FA46A5DBA2" modified="2025-10-08" version="1">MPPKAPVKRTAASSSSTAPRKAPRAGPSTTAATAKRPATTSSTVAKGKAPARPSASTQVDVKPKLEDTRGEEEWADLMKQQYGDKKGADWYSKGVKTVEDKWQLLPAFLKVKGLVKQHLDSFNYFVNVDIKAILAANSLVISDINPKYYIRYTDIRVGRPARHDANQVASALSPMECRLTDSTYSAPIYVDVEYMGEEKRSKQRGVQIGMLPVMLRSDLCNLKGKNEAELARMGECPMDPGGYFVVKGTEKVILVQEQLSKNRILVMKDKKDEVMAEVTSSTHDRVVKTYVVSKANRLYLRHNSFKEFIPIVIALKAMGLTADKEILQLICGSDERYQEAFGVSLEEAAKEKTFTRRQALEWIGARVSPNQAKDDSGSNQKLTPSDIAQQALAAMVLGHVPVRNMNFRPKCIYLATMTRRVLMAMIDDHMVDDRDYVGNKRLELAGQLLSLLFEDSFKTFNSELKKRMDKILEKPNRAGPFDAGTLIRQGGDPITQAFVRSISTGNWSLKRFHVERAGVTHVLSRLSFIAALGMMTRISSQFEKTRKVSGPRALQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDVPEAPLVKMAFMLGVEDISLVTGNELYRPGVHMVQVNGTLIGVTNMAKKFVRQFRKLRRAGRMSEFVSIFINHHHKIIYIASDGGRICRPMIIVEKGRSRVTTEHVRLLKEGKVTFDHFLRAGLVEYLDVNEENDAFIACYENEIEEGTTHLEIEPFTILGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIAYNQLNRIDTLLYLMTYPQQPMVKTKTIELIGYNKLPAGQNATVAVMSYSGYDIEDALILNRASVDRGFGRCHVLKKVTTPMRTFHNGSHERTAYPDPPPRPDAYTFVDKADGMTAPGATINQYDVMIHRETPVDTRGGGADTQLYKPMPVTHKTPEPILVDKVMLTEGEDGALIKILTRQTRRPELGDKFSSRHGQKGVCGLIVPQADMPFNDQGIVPDIIMNPHGFPSRMTVGKMIELLSGKAGVIAGKLQYGTAFGGSKVVDMSQILIDNGFSYGGKDMLTSGITGQPMEAYVYFGPIYYQKLKHMVMDKMHARPTGPRANLTRQPTEGRSKDGGLRLGEMERDCLIGYGATQLLLERLMISSDAFETQVCENCGMLGYNNWCPKCKSGNGVVGLTIPYAAKLLIQELMGMNIMPKLCLEDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNV9</accession>
    <name>A0ABR3BNV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612837.1">
        <property type="nucleotide sequence ID" value="XM_066759350.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991745"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="533" mass="59380" checksum="F7C16855AB2287CE" modified="2025-10-08" version="1">MRTQSADKKRRVTCLASNNLLLHLNGLMFPVSLILTKVLTIFHFYAHLTIHVASLTDSTTNTKQRTESYCTMSGTTSPPQTDSLLNLAMKPQSHKSWFSFSRYKPNSIKGEEASLVSTDLLPAAAFSNLPNPTLYVSPSERDLYFAAMSQLDQGPPLLPLWTDPAPELPHLNLIDPRGPPRVPRAYTITKPALGLDVWTDRLHNPKLFPGDVYDPSSCTGLIVRDEFRSYSAMKSANHAIVALSPPGEMRFTNFPPSVLLVLDNLIRDEWSQGKRKGTEELDTIRLMLGIFKVVRVHGWTLVENIQAGGSKKDTHDLLFSYSSEITLAPPVFFALSIPLPDRLSLINLPLKSTPALISALRTSIISTSPFKFKQSSNGIINPTSTDEELLKASEQGKKKGKITWQGYDQRGIKLEGWVHDGVYRFWIDGFRSWMRGALRRKTVEKIHPMLVISIVNNLTANHFQLAGSVPLLPFIKGRDVLIFQSLPSSRLTAQDSYDTKQYNSIRGADPLRPTTVGVQGKTGGKFGLSREDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP18</accession>
    <name>A0ABR3BP18_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Pre-mRNA-splicing factor CWC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_104957</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612905.1">
        <property type="nucleotide sequence ID" value="XM_066759418.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991813"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="141"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0245821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="346" mass="38988" checksum="8F0D019FEF21708F" modified="2025-10-08" version="1">MSADNAVAPKRKLKPARKQVASDEVDKSQGYQAGREYNIWYNKWAGGDREDALASKVHSQTRCIISRDAGYTRADATGNKYCCLFFARGCCPYGYECQYLHRLPLPSHQLPDNSRDCFGREKHADYRDDMGGVGSFNRQNRTLYIGKIQESPDKKQMTETLLRHFGEWGKIVKYNILFGRGVAFVTYETDHQASFAKEAMANQSMDGDEILNVRWATEDPNPGEKIAEEKRIEEIGQKAIAGMLDEDLVEATQAVRALEDGDVEDFYHIEASKPEEDEGEEEENRPAKKGKSEGGFFNADALDNIKFYAEMVKKQAEEEREKARKVPTKQVGMSLLGGYGSGDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP76</accession>
    <name>A0ABR3BP76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104847</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612796.1">
        <property type="nucleotide sequence ID" value="XM_066759309.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991703"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="105" mass="11408" checksum="90D53275B63D36C0" modified="2025-10-08" version="1">MVCKKCEKKTSTLATTDPFQPASSTRKIGENKLLSARAKAAPYTKPGQGSKKGSINPYGNKCIDCKQSVQQNNATRCQKCAYKKGLCAICGNLILDTSRYKQTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPP0</accession>
    <name>A0ABR3BPP0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612820.1">
        <property type="nucleotide sequence ID" value="XM_066759333.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991727"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0245736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="243" mass="26678" checksum="9E43DFAAFF2DFBDF" modified="2025-10-08" version="1">MTAPFTVTFDAKHGLQLDAYLPTISIHRSCQVHDMIEDVRSLFAYIASAETELSSVLYSNGLSADTSRIVVVGVSGGNYPARAAATLSSIVPRPIGWLNLSGMGSDWLLNFWINGIDVERTMPLDTTVHDMAKADELMKTGGGAVVSAVESVLVDGKATDELGRFNLWIAWQKWGIFLDYVLSEPGLSARLAQVPYQSRLQMIPKKKRRLLLPITPGTPPTYVLHGKEDLLVPFEESLTLEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPU4</accession>
    <name>A0ABR3BPU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-soluble NSF attachment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104672</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612624.1">
        <property type="nucleotide sequence ID" value="XM_066759137.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991528"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0245540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32289" checksum="637034B622B0CDD2" modified="2025-10-08" version="1">MPSRAEELFAKAEKKAASSVGWFGSSSSKWEEAADLFSQAAVAYKIDNKWQESGQAYEREAACRLRVNENNDAMNAFHNAAKSYKKSNPEAAVTALHQAIKLLIESGLFRQAADREKEIANIYAQDGIDQAKARDSFVRAGDWYKQEDANATANQCYQQAAELSADLGDFQKSMELYQTVADWSLTSPLTKYSVKEYWLRAALCSMAMGDLVTTHKLLTEFAQKDLTFPSTREAKFAKDLMDACEEADLERFTGTVYSYDQVTKLDNWKTGVLLRIKRALEEDEGGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ29</accession>
    <name>A0ABR3BQ29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_104337</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613262.1">
        <property type="nucleotide sequence ID" value="XM_066758814.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991193"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="14">
        <location>
            <begin position="58"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="15">
        <location>
            <begin position="575"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0247301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="775" mass="84285" checksum="E58FB48063EF8A31" modified="2025-10-08" version="1">MLRLIRTLQPLQRRGLATINSRIQGSPLEPSTFIDYEKVSQQIAQVRKRHGKPLTLAEKILYGHLEDPNAQELKRGTSQLRLRPKRVALHDANAQMALLQYMTTGIPRVRVPTSVHTDHLITAREGAGPDMDRAIAANKEVYDFLQTACAKYGIAFWKPGAGILHQVIFEQYAYPGGLMIGSDSHTPNAAGLGMLGIGVGGMEAVDVMAGLAYEVKHPNIIGVNLTGKLGPWSTTKDIILKLASILTVRGGTGSIIEYFGSGAESLSATGMGTIGNMGAEVGATCSVFPFNQGMADYLELTGRSTIARAAENYRDDLKADENAVYDRLIDINLSELEPHINGPFTPDLSWPISGMGEAVKNTDWPTDISAALIGSCTNSSYEDLSRAASIAKQATQAGLKAKTEFFISPGSEEIRSTVSRDGVLEELQKAGGMVLANACGACVGQWERPSMKKGTKNTIVSSFNRNFIGRQDGNPGTHSFVASPELVTAMAFAGDLNFNPIKDNIQLSDGTHFRFSPPQGPPLPEKGYERTLQFYDEPPVDGSSVDLAVDPNSNRIQLIKPFEAWDGKDEQDLTMMIKVRGKCTTDHISAAGPWYKYRGHLQNISQNLLIGAINDENGKTNSVRNVDTGEFGTVPSTAEYYRDSNRKWAIVAGDNYGEGSSREAAALSPRYMGGFAVIARSMARIHETMSSTLNLKKQGLLPLFFRDSTDYDKIMPGAQLKLSNLQGLAPGSIVYLTYTNAGQEPIQIELFHSLTDRQITWFKAGSALNTLRPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ82</accession>
    <name>A0ABR3BQ82_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonuclease P protein component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104387</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613312.1">
        <property type="nucleotide sequence ID" value="XM_066758864.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991243"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="324" mass="36511" checksum="B440A393B269358C" modified="2025-10-08" version="1">MSFPIVIFRAIKRQRIRDLSTTCYCQTPCKPGGPSSPSLGARAESTNPQGARVGQRSRTQSMPDIAPKLRGATNEMMWYLQRDSKWQPQESKGLNLLDRLDRPVRRVKSDNRGVNRRESSWEPPEGKPRAVIGMSPSWEERATGKRVVFIGIDMNTALPKIFATKTPVYRSSGLSIRAFPAQLLPPRPAPPFPLDLVSKTRRENPCVYLSIITSKNQVSKLAVERNRVRRRLKAAWDRVINEGSEGWRLVSPDYAYVVSVNGEVHDAEFESIVQEVATGLRFLQQRRPKEMSRRSGSGMVPEPKYISRIKLQTEGIGREISGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQN6</accession>
    <name>A0ABR3BQN6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allergen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613463.1">
        <property type="nucleotide sequence ID" value="XM_066758061.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990423"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25826" checksum="EBC1DEDDDEE3E48E" modified="2025-10-08" version="1">MSSVTQGVKEFFSKSGKPETTEVCTDTAPEVVQEHIRPQEHVETAEAVDRERHVHHLQHRIQPVEDHQTLNTKHVNATEPVITREHKEEMRPEHQEALAKQKNLAHDTRSTGAVEKSGEHVGAALNEHQHHHIHETIQPVVQRETVEPTVVHQTKAIHEKVEDAPVVHEVTTLPTISAEKYSQNKSSLEGEGAHCSTFEGAPQVAGQSANVSANNGTADSISNGQHHSNKSQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQQ0</accession>
    <name>A0ABR3BQQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613481.1">
        <property type="nucleotide sequence ID" value="XM_066758079.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990444"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046779435" evidence="1">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="83" mass="9592" checksum="7DF260ACF4FB4517" modified="2025-10-08" version="1">MRHFYLLVALFTLFTTVMAFPLIYHQEAEAARAARALENSNALTNSERIARGLPVKQPKRYYDASQTRVLNPRASARRKRENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQR7</accession>
    <name>A0ABR3BQR7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104041</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612969.1">
        <property type="nucleotide sequence ID" value="XM_066758521.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990897"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040039">
        <property type="entry name" value="PIGX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0247008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="243" mass="27172" checksum="0DE9958BFED34589" modified="2025-10-08" version="1">MSLQPLNIRLSFSQPSFHPVLHLTFNAPSFSALDDASNSVTEKIKPCEPVAHLEIALPDALFVDPDELNGKWPLSSSSEAAMHQAAGSNWEVSDWKLDPPSVDIERPSFGSPELRHSLYLSMRPQVFLEECDIQSEVEMEIPLHARYLAPSDEGKRTLLFPGDDKSEIRSGWTCASELTQGHHVPTVHHSPLSLTLPTGQHAHQPVIEILTCLVIWVGWVWVALKLWKSKRRVPARESKAKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQS7</accession>
    <name>A0ABR3BQS7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613502.1">
        <property type="nucleotide sequence ID" value="XM_066758100.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990467"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="7">
        <location>
            <begin position="242"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="566" mass="61837" checksum="A83699E254C28FF3" modified="2025-10-08" version="1">MDPNAEDRPKSVQIAEIDIESPEQPQRERAPRTDFGRTENPIVPPSIQAPLASSIFRQALDAGRPPPTGPALATEPITEDPGKVRQWQEEEFQRRLRGEYEQAQRRVGEVVTSNMERPLRLTSIRLAPPPPTTRSSFTSALLSPFLSKPHPNVPSWLHPAPPPPTTLHQILLTTRALVQHVDKFGVYDMDHSGVRLEPRRGGDPDEVELVLALREKGRLFLKAGTEIGGGEGGGNVTARIRNILGGAETLEGTASLGTKTKSAYQVSLTTPLFASPLLSFALSAFSLDRDNSAFASHRERAQGGRAKLSAITPWGTHDLQYELVDREIDRLTPNASVSIRELAIPSTKSSIAHTWTSDTRDDPWMGTSGRLLKMTHEYAGLPGSSKFAHFFKSITQSQLSRELIPGSGVYYSIASLTTLLYPLFPHSPTSPSTTYLPDRTFLGGPNSIRGWKVGGVGRRDGPDSLGGDMSWALGLSVFAPIPKKEHWPLKLHGFLNGGKVVAYDTSRGFAENVAKMYSAPNLSVGLGLVYRLEPLRVELNFAMPLVGRKGERMARGFGVGVGIEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQS9</accession>
    <name>A0ABR3BQS9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613484.1">
        <property type="nucleotide sequence ID" value="XM_066758082.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990447"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="163"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="642" mass="71718" checksum="18B57CE233005EC3" modified="2025-10-08" version="1">MPPVAGHNIPPRLRQYHQSQIASNGVMPYQRHPPPRIPSTRSLHLSISLLIVAVIIVYAQKQSFMKGVLPSKVYSVTETLPEKYAICGKEGKKVYTVPYEVEAVIERTAEWEKEAVGAVECVVVGNDKVVDRGSLSKIRRKWAKDTLSKTTRDDLQIIHLSPGHTLTPGFTDSHGHPLVYGHAQQLPLHGCRSIEEVIAKVEDYVNHHPLEEGQWIEGLGWDQNLWKDKVFPTAEEFDKSDILRGLPISLARVDCHAEWVSTAILRLMDNILDVEGGTVVRDSGGKPTGIFIDNAISLLTAIRPAWTDVDRERFLDIVVRDALSHGLTGAYDAMGLVSDQPFWRRMAEEGKLPIRFYSMLSCEGEDFCGDKVKPYYNFEKHYYMRGVKLFGDGALGSRGAALIDDYSDQPGWKGLMLKKEEVWGPLIKQWYEAGWQVCLHTIGDRAAKVVLDAISSVAGLPDIRKARFRLEHAQIMTLEDLERAAKMGIIASVQPTHATSDMWYAEDRLGTERIRGAYAWRSYLNNSGHITLGSDFPVESIDPLKGFYAAVTRRSPEGKSPHGKGGWCPEQKLSRVEALRGFTVWGAYASFSEDYVGSLTPGKKFDAVIWDDDLLTVPEDEILDVKVKGVIVDGRLVWGTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR10</accession>
    <name>A0ABR3BR10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UV damage endonuclease UvdE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613059.1">
        <property type="nucleotide sequence ID" value="XM_066758611.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990989"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="494"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="575" mass="64306" checksum="DB92EE419533AFA2" modified="2025-10-08" version="1">MPAPFPPSKPPRETLLAVALSMDEDNVTPPPASDAENEQVGKALDGAAVRVLTKRKRSSKLIVEEEGMENEEVSSTKGKKRGRKARDELSTAKKEAEREEELDVKERLTTPANGKKSGRKTKVESAVAAENEEQEKKPKKKAVKKSRIAENEPQYDEEGNEIVTRNRKPRVYQKKIYEIPDVERKTTTFRGRLGYACLNTVLRANKPNSIFCSRTCRIASIEEEGLELPKGLGLMNMRDLKTLIQWNEDNKIRFMRMSSEMFPFASHAKYGYSLDFADAELKEAGELAKKYGHRLTMHPGQFTQLGSPKKAVVNASIRELEYHCEIMDRMGLGPDGVMIIHMGGVYGDKDSTLARFKENYTTLASDKVKARLVLENDEICYNVDDLLPVCTELDIPIIFDYHHDALNPSASPPAELIPRIAEVWNRKGIKMKQHLSEPRPGAESIMKRRAHADRCQTLPAELPDDVDLMIEAKDKEQAVFELYRIYGLEDVVHDNLRPPDPKPGMQTKGRKSNLKKKAKEARDVDPLGEPVQLSDIEKGGDGGAGDEVVKKGGEVAEAVDDAGMEIDGEATKEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR45</accession>
    <name>A0ABR3BR45_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_105334</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Vacuole membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612438.1">
        <property type="nucleotide sequence ID" value="XM_066759791.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992190"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0244071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="167" mass="16784" checksum="B0AA57A8F2EAF63E" modified="2025-10-08" version="1">MSTVAELCPVYAPFFGAMGCTSAIVFTCIGAAYGTAKSGVGISAMAVLRPDLMMKCAIPVVMAGIIGIYGLVVSVLISGNLASPMPLYTGFIQLGAGLSVGLAGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILNTNSAVDYTCSIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR47</accession>
    <name>A0ABR3BR47_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613628.1">
        <property type="nucleotide sequence ID" value="XM_066758226.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990600"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="608" mass="67371" checksum="AA44BFD5D61E91BD" modified="2025-10-08" version="1">MEPPHPSASPFRFRHTLNRLKEFPPDLSDGSDKANDIILALQLMRNSPATEEAAFYGRGEASMTLESLDNAGVRRPDGMLLAYTCHRFASIDEMPQLAAVEEGRIDVLPPATPHRRSASPVIHTRPYALSDKTTPVVSPMPSKTSTRISSTFVKGLHLDPCEAPYIITPLTIELKPEEGDVRLCLLQGLAYMVGAHDTCGSVLGYFGHGRRYSRAIILDGETVLFETTDEGDKLASLGSIKELINFMADKTLPRCYGTYDKPDVKAFEDAYNFALVGLRMVLDLPLGERLCRLKAPSGESWERLMDELQMKARYPKTREDVECMFDILLPDIAKKNGQMRRYKEAAMLDKMAAIPSQGTTAERADIFESQEGNKFEVTEEVKTRKAKKKKTSLPEAGAHKSSTRFRDPSPSSDGRGGREVGRGASRGVEGSHQLDRSSRKREAPSPEGGRNEKQSKSNENREEALSSVSMGSADSVPLPITPPEIVSKWLFDPFTNGLCSSKEGLKMCSGANSGPENGKVHSPVPELVEEKEIKPPASQAVDENEPDIPISQRGDEEDIDEEMERREEEQKLYLALYSVLEQRGFRFLLGGQKVFQAVLKELTDQYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRG1</accession>
    <name>A0ABR3BRG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_103674</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613561.1">
        <property type="nucleotide sequence ID" value="XM_066758159.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990530"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="10">
        <location>
            <begin position="65"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="9">
        <location>
            <begin position="259"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0247600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="534" mass="58863" checksum="6BC43615B174039C" modified="2025-10-08" version="1">MDTSVLRPTPSLEELTNLFATASSSTTTLTSRSTTLFPTPNAEPSKPVEPAKPNLIPVYVEIPADLLTPVSAYLKIAKDEKYSYLLESVVGGESLARYSFVGSNPFKTIKTGAGEEVEGDPLKALEKELEPYRFAKIPEISAFTGGAVGFITYDAISHFEPVTTPATPLHNPIPGMPEACFMLFSTNIIFDHIYQTVKIVSHVYLPDGTPTSEIPSLYDEASARIDSVRRKLMSPETPMPPQGHITLGNQSESNVGKVGYEGFVTKLKEHIVKGDIIQAVPSQRLTRETALHPFNVYRHLRRVNPSPYMFYLDCGDIRLVGASPETLCKVEGRKVYNHAIAGTVKRGKTEEEDAVLGAGLLASDKDRAEHIMLVDLARNDVNRVCKPETVNVDNLMQVEKFSHVIHLTSQISGILRDDQSRFDAFRSIFPAGTVSGAPKIKAIQLISGLEKERRGVYAGAVGRFDFDRDNLDTCIAIRTMTFKDGKVFLQAGGGIVFDSVEEDEFVETINKLRANVKCIEEAEKYYARLQGQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRR6</accession>
    <name>A0ABR3BRR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613666.1">
        <property type="nucleotide sequence ID" value="XM_066758264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990639"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="105" mass="11424" checksum="4DADE819EFCE90B2" modified="2025-10-08" version="1">MSSISRSLLANDIALLRSIPASSLPLTSGQSEPSDSQTPLEVLQAFSPSSATTQSSQDLSKAYIKEMNGIKEVYERKEGEEVGERIDGLRARGEEIQEVLRDVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRV4</accession>
    <name>A0ABR3BRV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_103996</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613879.1">
        <property type="nucleotide sequence ID" value="XM_066758477.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990852"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="13">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="920"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="480"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="928"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="974"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0247918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1036" mass="112854" checksum="8B89413B54D01B85" modified="2025-10-08" version="1">MISAETYQPNWAVRAVTTPTKDTDLCLYVSFDNVRFLFGCGEGTQRAFAQKKIGFSRLGGVFIGSGELKGRGGLPGVLMSASDAGISKIDVIGPPDVSQYLATLRSSVIRDTLTVNVTPYPRDVATGTSVKLFESRNITVHGVALVPRLNSSINEINMVYPPYDPYSATFQPSHLSPSDLQKWCDHVVRDMFQNNAQARLSKRAPSPTPPPTSPRLGSPIGSPKRPRASNVFLAPDGTINAARPDPRAPLPLPSDVDVETQMVYICQAPDVRGKFDVAKATALGVPNGPLRGKLTRGESIEVSDPNVEGGTRVVRPEDCLIGGGKGGTLVIVNCTEKTLQALLDCEALRQWQKKTPAGEKEGEGGVDVMVHRVPRSVWGDERYQAWIQSFGEKTKHLIANTTPATDHAVFNSAAWNTLHLSLIEPTIFHPPFLRHSSTSFTGLESTLPSNVTFIHPNDFVKMYPPSPLETFPWHEKDIPFTVTENQADDAREKVKKEKKEYGEVCEKARNTVRQLDMEKAKTKEKSNGNEHSDDIVVTTLGTGSAIPSKYRNVSSTHLAIPSLGGILLDAGEGTLGQLRRRFGDGLKSILEEMKMVFVSHMHADHHLGVNAVLEERFRLGITTPLYIVAPYLIALSLQETATWQAAGTEEGLKNVRFLCVERLGERISVDIPVEGDPQKIEWTQKEGGGKGRWPFVPLHGFSESVSKIQRHYLRQLFVDLGLTAIYVPSVPHRGRAYGLVLEGNPAGKDGVKRKEWKIVYSGDTKPSQKLVEAGKGATLLIHEATLEDDKPEVAAVKGHSTFSQAIDVGREMRAKYILLNHFSQRYPKLPKLPMPTSVAPGVQAPSTSTAEPNGVVDEIATLSTSSTSLEVSTEPIVSISFDFMSLRLGDMWKMSYYMEGLSMLFAEPEDGEDVVEEAQATEGVNAGGKEKKEKGEKKDKGYGKESTIAKGSGGGKGNNTVVAGPALKSKRSLKKEAARAIKAKAEDERVTASMTGVAVGGVQKETKEKRARSPGLEGPDRKRRSTDVEESGVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS18</accession>
    <name>A0ABR3BS18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ethanolaminephosphotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613434.1">
        <property type="nucleotide sequence ID" value="XM_066758032.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990394"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48041" checksum="1AA71A728FEF27DB" modified="2025-10-08" version="1">MRITKSQFTGLDAYKYSGIDKSVVSKYILGPFWAWLVTLFPKNIAPNTITFIGLCFVFTNVGTLLFFDPMYQGAALPTWVYLSFAFGLFAYQSMDAIDGKQARRTGMASALGEMFDHGCDAINTTLEVILACHALGLNQSWWTVASQVASLCNFYVSTWEEYHTGTLYLSAFSGPVEGILLIVGIYIITALHPLGSSFWSQPLLKPVLYLAPQLFPYVQKVDGLLESFGVWKYVRLESIPANVAFMSFGAVGTLANIVTSYHNVITSRRKAGKAILPPLFGLLPFFTHTAILVSWLHAELKGGVCIVHDSRMLPFLGYWGMAFSYQVSQLILAHVTKSSFPYWNGMMIFSLFGAADANMGWLFGREPLVQSSPVAANVFIWMSFVVALFNYVRFAREVIWQICEYTGLACFTVRHKDENGKWVQNGKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSF8</accession>
    <name>A0ABR3BSF8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103191</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 10">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 10"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614075.1">
        <property type="nucleotide sequence ID" value="XM_066757691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990047"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="12">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="799"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0249888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="863" mass="96936" checksum="57B40592F7BA9929" modified="2025-10-08" version="1">MVMWIYKRDGRKEPVAFDKVTARINKLSYGLDPNFVEPAEITQKVVQGIHAGITTVELDNLAAETAAYLTTKHPDYAILAARIAISNLHKETKKVFSAVVHDLHAWVNPKTGKHSPMIDDEVYKVVMDNKDILDSAIIYDRDFAYNYFGFKTLERSYLLRINGKIVERPQHMIMRVAVGIHGANIDKVIETYNLMSERYFTHASPTLFNAGTPRPQMSSCFLVAMKDDSIDGIYDTLKTCAQISKTAGGIGLHIHNIRAKGSYIAGTNGYSNGIIPMLRAYDATARYVDQGGNKRPGAFAIYLEPWHADVFDFIDLRKNHGKEEVRARDLFYALWIPDLFMKRVESDGDWTLMCPAECPGLADVYGEEFEKLYESYERQGKGRKTIKAQKLWFAILEAQTETGVPYICYKDAANSKSNQKHLGTIKSSNLCTEIMEYSSPDEVAVCNLASLALPAFVDLERRVYDFKKLHEITKVVTKNLDTVITRNYYPVPEARNSNMRHRPVGLGVQGLADAFMALRMPFDSLEARELNIQIFETIYHAALEASCELAEEQGTYESYEGSPLSKGILQYDMWGRVPTDLWDWTELKAKIAQHGVRNSLLVAPMPTASTSQILGWNECFEPYTSMLYARRVLSGDFQVVCPWLLRDLINLDLWDDNMKQLIIAAGGSIQSIPNIPDDLKKIYRTVWEISQKAVIDLAADRGAFIDQSQSLNIHLSNPSFPQLTSMHFYGWKRGLKTGCYYLRTRPSANAIQFTVDASTLKTAKNLSSSAKPSPTPSPAPGVGRATADSLVQPMRKVTIATTASHHPPQPNEASDSRSRDRSPQPSEEEEITYEEAKRRAEERAEAALQCSIENKDACLMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT01</accession>
    <name>A0ABR3BT01_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613990.1">
        <property type="nucleotide sequence ID" value="XM_066757606.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989961"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="384" mass="40227" checksum="F64CDD4974F084DC" modified="2025-10-08" version="1">MEFLASSQEINKPKQLYPCLAVVDINASSDKSRRLSAGSFGSDKDEGNVLTRVISGGGRRKSSFGETGGGGGGRRLSFGGRKDDDKVEGKWYWRVQVGVNDTHLVLLPLTQPPNPLLTTRPAPLSTAIPSHSTHETSTHHDESAIAEHEGGGGEPGFASRVKNIFRRASSSLKERPSAPSASETTSGGTNIAGERLTDQTERADMLPSAGGNAEGATNLNSSAELGWPGIINNEKLAAILIPLSSIGKKVGLGGGKKAEGSWVSVQVTSSAQAMEPIGVNKFEPTPKSGFVKFEFDKDWLGAKGEAEVLHHYITTAAASAPPPAERTAPNPSAFQLGGQQATSGAYQQTQPSDPLFTGTTFGHTGGAGQNVDRPLVDEAIAPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTA4</accession>
    <name>A0ABR3BTA4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103497</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614376.1">
        <property type="nucleotide sequence ID" value="XM_066757992.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990353"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="51"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0250189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="398" mass="45143" checksum="913D8D0AA2B07694" modified="2025-10-08" version="1">MSTSTRSHVPDVNHKADSNAAANAGQVQERTTKGSSSSAPRKVRFNVGNNYHVVDVIGEGAYGVVASAVHRLSGSKVAIKKIAPFDHSMFALRTLRELKLLKYFAEEGVSENIISVLDIIKPSSYDTFREVYLVQELLETDLHRVIRTQDLSDDHCQYFLYQTCRALKALHSAEIIHRDLKPSNLLLNANCDLKVCDFGLARSTQTAFPAEGNNQGFMTEYVATRWYRAPEVMLSFRMYTKSIDVWSVGCILAEMLSGKPLFPGKDYHNQLALILDVLGTPTIDEFHAITSKRSKDYIRSLPFRKKRAFESLYPKANPLAIDFLSKTLTFDPRKRYTAEQCLIHPYLNAYHDPEDEPSAKPLLPSFFEFDMVKDDISREELKRLLYEEIMGFNPVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTA5</accession>
    <name>A0ABR3BTA5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613218.1">
        <property type="nucleotide sequence ID" value="XM_066758770.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991148"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="50993" checksum="8E69352979E65E03" modified="2025-10-08" version="1">MSSSPEPTALTDPSSYLCLSKFNRRLRRCPRTNLPVTFSDIGDSVGIPLLYLLPSGCSRWIGASLDPLAAKFGVRMIIIDRPGCGGTGQVPLGERIERSCEMAVSVLESLMIKPAHILASSAGIYYALHLLIHHPSAFRTSLNPPPRLYLIAPWVPMLPIDDPESWPFKWDWIPTPFIATQHITTPHLLKAAEQAQKAYVRGLKAIDTSRSFVMKMYKSFAEASSSASYPSAQATTAPSMSSAPYEQTSIKPGMKKSVLEILNNTMEVGMEEDTQVQVPQSEGEGDKQEGYWGSTPCCVTCLVSGYMQAENGQGIGQEHLVCLNRGPRDTGEVWLRTALSDLAATIQFSQGSLSSASSAEKLASNSLQTGQANEADESGAGGHVNDVKDPLEMHVWWGWMDDMVVRKGQLYFNQLVGRYSGVIDLFVHDVPDGDHSDLMSRPEGIYHCFELIRSEEDSTTSSREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTE4</accession>
    <name>A0ABR3BTE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614408.1">
        <property type="nucleotide sequence ID" value="XM_066756939.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989251"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="483"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="616"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="629"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="709" mass="75052" checksum="46E2707D8C978C46" modified="2025-10-08" version="1">MAPRQPVAGPSKPKHSQQPAVQSPPPPAAVSAFNSTRTLFALASPVLGQADKVQVWDVASDRVISEWEVAGASKASSVCFTTVPSDAASKKKKRRKSGSAHGAEEEVVLVTTSKGQLLVLSTKQTEPLRILDLPAPVTAAWSEERASVLATASSLLVLSADASSISHTFTLPSSHSSPSAIAILPTSTTESLHVLVASSLVVNLHLELATQEVTFVSSPLPASTSSISSLLPLPLTEQGASFLVVSEDDRTISQYTLTSPQSPARLSYRYASPTLSSAHSISVDPDLLAVLHESGEISLFRLPSELDLSRPQSDAKPSTVKVVEGKEERTARLCRVAFAPVDHGALGALLCGRLTGGGRVKWSRAIYELPEGGLRPSTVVKVEAQELVGGSSTSETVPIQRFVAPNTVNEAVPEDVDEVPVSQLPSDVNMAELSLGERMLAPASQEADSGNKPAASSAGITLDGPVNAASLTRVLVQALHTSDPALLTLCLSHRNPVLIRNTIRKMPPQLALPLLKACVERLGQGKGANKRGGGRGAAQNEQQGRGTVEWVKGVLVERGSILMTMPSLPVHLASLSQLLQTRLELNQPLQSLSGRLDLALAQITMRRIAAEQALENAKNGGQKGGEGEIYVEGESEDEDEDIIEVGEDDGEIEDIDMGGLSESDESEEEEDEEEESDEDPLDSGSDNDLLDLQAEESGSDDDEESEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTH3</accession>
    <name>A0ABR3BTH3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613929.1">
        <property type="nucleotide sequence ID" value="XM_066757545.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989899"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046894409" evidence="2">
        <location>
            <begin position="21"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="311" mass="30145" checksum="38E9B5F5CF2CE305" modified="2025-10-08" version="1">MSKALFFIATVAISAAVVRAQAAPNWQYIPSSCASQCAQTIESAYLCETTYTDGTEVYACFCNNFPSDASACATCLNSNDASAIASVLTSTQTACPSAISQCHFECDFPTCSSTDVACQCDATYLENIYNCASCNTANGNTAATQISDFQSLQESCANQNYTGASQSFTTKALPSIATNGYTAPSLSASGGGAAASDTGAVVIGTTSGAAGTTADAAATSDSATASSSSSAASSSDDATTSSAATAGAATTAASHTSAGTTAGSASHSTSHSASGSTSASASSNSSSSGAGMVTPAVGGVLAVAGAVLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTM8</accession>
    <name>A0ABR3BTM8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614492.1">
        <property type="nucleotide sequence ID" value="XM_066757023.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989335"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="425" mass="47308" checksum="FEA82119C25D27C6" modified="2025-10-08" version="1">MSLPAPGSPSFSFLLLQHVLSHPSLKGWVVSPPLFSTILLILIVKNGGLIIDVDDYKSDRVVEVVRAMMRSIFGLCVGHLSVSSSTYTEELPWKLFQPSTARISQSSAHASASAKELKGNLYSNTENERDNYHHLDKDRLMIPQVLVLTGLESAASTVQMKLCEYLTKKRIEVRAGHEQGTLEDGMMKLCDFDPMVIWIRRSGADAPWWVIDHFMCATTIQSSEISLPPSDIDLGAIIPQSYLATLSLLLPYTHIHPPLAVHISNLFSAITCHPSLHSAITQRAVRAFPEYVRAHRLLVGDFVLPDGFEIRLQEEQDGLALATKDRPGTGGGVGEIHTWNVLAGEEPDINDLRGDCGRGEEQLEDWYATPSNVQGVWKVCMIHRVRKRQDREEVMWLMKGSASGGVKKSRRRRVGMILDEILATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTU3</accession>
    <name>A0ABR3BTU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">mRNA-capping enzyme subunit alpha</fullName>
            <ecNumber evidence="3 16">2.7.7.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 16">GTP--RNA guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 16">mRNA guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">I308_102402</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IND107</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the eukaryotic GTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="3 16"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614416.1">
        <property type="nucleotide sequence ID" value="XM_066756947.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989259"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017075">
        <property type="entry name" value="mRNA_cap_enzyme_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036959">
        <property type="entry name" value="mRNA_cap_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 16" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="18">
        <location>
            <begin position="43"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="19">
        <location>
            <begin position="242"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="366"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR036959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAL0250229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="423" mass="48938" checksum="8FC715A82BD504BD" modified="2025-10-08" version="1">MPAHTPIPDIPGELLTDPTLQYFLAERVSNLCGIGGGKFPGSQPVSFSSSSLDLLEKEDFWVCEKSDGVRVLVFIVVNQSTEQQEVWLIDRKQRFFKVQGLYFAHWENRSAFLGETLLDGELVIDIEPSTGAQTLMYYAFDCMVLHGENIMEKPLLKRYARLQDWVIKPFAKAVSANPDMRRTIPFLMVAKREELSYHLRFVMEEHIPKLKHGHDGLIFTCVHTPYVAGTDENILKWKPPSENSIDFKVELRFPPLPDSDEPDYSTKPEFLLNTWLGGDRYEFFDFMAMTDEEWQRFKESEEQLDERIVEVCWDSHIQAWKMLRMRDDKPHGNHKSIVDKILISINDGVEIEELYARADAIRAAWKEREKQRSQQRQPQNQRPPPQGYGQDLHTPGHGHSHTGYNPDYGHPPPQQGVMSGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU32</accession>
    <name>A0ABR3BU32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_103486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in mitochondrial fission.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FIS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614365.1">
        <property type="nucleotide sequence ID" value="XM_066757981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990342"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="154" mass="17292" checksum="2366C851E4BF8CF1" modified="2025-10-08" version="1">MPTDLPYAAEAESSLSPDELEVLRRQYYKEIEQGHVTIQSKFNYGWGLIKSPSPELETEGVKLLQEIYSASPDHRRECTYYIAVGYYKLRNYAYARKFNNLLLSVEPGNMQAQSLSTLIENAVKRDGLIGIGMITGAVAVVGLIAGSVWKRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU34</accession>
    <name>A0ABR3BU34_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_103612</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion outer membrane</location>
            <topology evidence="2 15">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613503.1">
        <property type="nucleotide sequence ID" value="XM_066758101.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990468"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01893">
        <property type="entry name" value="Miro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="4"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="426"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0247542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="657" mass="73744" checksum="548BF575A6A30452" modified="2025-10-08" version="1">MPRRDLVRIVLVGDDGVGKSSIITSLIKEAFVTNVPHVVPEVTIPSEITPENFTTSIIDTSSNPRSRPHLLSSISRAHVICLVYSIADPSSFDRVAEYWLPLFRREGINVPVILVGNKIDLRGGRVTNQGLEDESAPIMREFKEVETVVECSALLPLNVSEVFYFAQKAVLHPTAPLYDSREHTLKPKCLEALKRIFTISDVDKDGLLNAHELNQFQQKCFSTPLQSQELDGILEIIRSYDPYAVQPLPSSKGITELGFLYLHTMFIQQGRMETTWTVLRKFGYGESLDLREDFLAPRFDVPSDCSVELSPLGNQFLTDIFEAYDKDQDGALSQHELDDLFSTSPGNPWLSQGFPDTTITDDMGRVTLQGWLAQWSMSTLLSHRTTLNYLAYLGYSSSPATDLPTPTALHVTRPRKQDRRQRKVTRNVFLCYVLGATGSGKTSLLRSFVNRPYKGGEDGLGGYEPTTKVLSVVNSVEMEGVEKYLVLQEFGSKYESEILRNSKRLDMADVIIYVHDSSDTNSFSYISNLRQQYSLDHIPAIFVATKSDLDLAQQRHEVQPDVYCRRLGLQAPMAVSSRLGPLHNLWVAITRVALDPTSSLPRGPRSQMSPAQRIRVVARWGLAATTISAVVAVWMRWQGYSFKGVWNWIAKFAGLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU61</accession>
    <name>A0ABR3BU61_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614395.1">
        <property type="nucleotide sequence ID" value="XM_066758011.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990373"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="160" mass="16450" checksum="79AB1D98A1C602F4" modified="2025-10-08" version="1">MSVNAQSHPEPIPIPGASHVPASPTSVPSDVATPPDARRKSNPSPPIDPSRLNNHPAPLPEQPGSSQNEPRSPPLRSPQDSTSPHSVTTAGSAYLDTGLPAEPASHPTVAETGALSSSHETGPRQGQLKRVEKKGDGGIIKLGSLGGDGLKVKPPMGRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU85</accession>
    <name>A0ABR3BU85_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptide hydrolase</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614697.1">
        <property type="nucleotide sequence ID" value="XM_066757228.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989544"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044997109" description="Peptide hydrolase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="8">
        <location>
            <begin position="301"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="515" mass="55800" checksum="906EF8FB0C527C7F" modified="2025-10-08" version="1">MSSLFLVLLFHSLISLVSTTAAAPITPSSPALFVSSDHLVHDTASCLKASYYGTYGGVPEEQDHIYIPTDDCLLTVSALDAFTSGSIVPIDDLMLGDGDRLVWVGRSGVSQIDSQAILPIEESWSLISSRSRQILSESDGRGGYGTQHVLQKTYELHHVRPIVLVHRTKHSLLVNVPSSFLPIFDTLLPPHLVPVALPSVPLPISVSGWQSVPEKFAKHLANITEHLSFSPELDKILSEGIRLDQIRRDVRWLTGEAPSGIKSRHSFTSGAIKTARWISSQVENTGADCTLQHFLPGFAPNVICHYPSTLNSTEHVIFSAHYDSRGSFGSTRAPGGDDDGSGSGHLLSLARAINSQGIVFEKAVTLAFFAGEEQGLLGSHAYAAHLYSRNATVLLQVQADMLGYHAPGEPLQLGLPEIIHLPEASYLIGNLSQLYSPELVVGKTAACCSDHQSFITYGFPATQVFERNGPIVDPMYHNSGDISQREGYDFEQIVSIAKVTLSALLTVAGYKRVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUH9</accession>
    <name>A0ABR3BUH9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102692</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614701.1">
        <property type="nucleotide sequence ID" value="XM_066757232.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989548"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049017">
        <property type="entry name" value="Nab2_Znf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21803">
        <property type="entry name" value="Nab2-zf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="262"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="543" mass="57863" checksum="8A4F25C917B21722" modified="2025-10-08" version="1">MARQFTSEQSAQLQSEVQAELERREWAEPNDNVMAEYITVLLANGSSRERVQSEMDDLVGSDFDPAFLDWLFVKSESIISDSSPNQPVPTPVEAEGAPLSTAAPRGNSRLLSSALAPLTSQPEKRKLSDSMDDGQNKRPASEVPVGPRLGTAAPRSPNMPTITARGRGMGIRGTASGGRGSAVNYSSVNGNFTHQQPSQQIQPGFRFRQQMHPGRFNQQIGGPGMLGMPNQQEMMAQMMMMQANMAQMGQMMSMMVGERQHTPFQRQRPSISQRGYQASAPAPVKLPPGTKLGSHSISSITPKSSNGGPVPDKPTSVALCKFGVGCSNARCPYSHPSPVADEKTGMVLSEEACEKGKECKDPECIKSHVSPSAVLGDTGGPSRLLCKYQNCNNPSCPFRHEDADGNPAPPPALAKNNKPTVAKAPASSSDDGSVEVINSHRGLLDGQLADGPKPIQCRFGDRCTRADCKFLHPASRSSVNAKKPLQASHTHPGNTTISLAGGMSKSKKFGADGKQGGLNPDAVEFKPTGHGEDKNGADLNVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVH9</accession>
    <name>A0ABR3BVH9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615128.1">
        <property type="nucleotide sequence ID" value="XM_066756351.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988657"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="523" mass="58818" checksum="0537AD84B1B6C66F" modified="2025-10-08" version="1">MSMIQKTPPRLPASFLVEESSETPGPSRARINNLQHQVSELVRKNQTLERKLTAVKSASESDLKERATKLSEMQESLRSTQRELERSKMELERCVLEGSGMKEELQLHSMVQQQKALLAVAQEQMLVVELEARLLDAEKARILRDHKITLFQVKEEELVREIEERDTRIEDLEVMLESSNASLEQERNASRMASSSQSTSSKDLSKAQMELASARAEISTLEDKVASLETKVRGLKDREKEARSELESWLREEGSASKYQKEKKESQVQLRAMKSELEKKKEEIEELKEDLEEAERSGKEKEKVLKKRLRDANEEKERLLGMEEELRGLRAGISKASTGNRRIRKESPMKEGSGDEVTTRKKAKKVETVGSSSEITSKERSKAKASTDSSSELDDLTPIPAKKSKTARKSPIKSKPKSTPLEDSNAENELDILKARASKSETVEQKSVDKEVTTAPAVEKKKKKRILGTQPPPTFNWDPVMNSGDGVIPAYLSPLRPDGVRATGNIPRAGFPSLPSSRLNRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW23</accession>
    <name>A0ABR3BW23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615308.1">
        <property type="nucleotide sequence ID" value="XM_066756531.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988838"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="198" mass="22996" checksum="872371C846FDB3EB" modified="2025-10-08" version="1">MRIEKCYFCSANVYPGHGTMFVRNDAKCFRFCSSKCHKNFKMKRNPRKVRWTKAFRRANGKEMVVDATFEFEKRRNVPVRYDRELVATTLKAMERVAEIRQKREKAFWKNRMSGNAAKNIRDNALEIERHIELVQPRSSTSTSKASEALEEREKVREKIKVRAAGRKAMALQQMGKGKKQKESRLIPAEGGSMGMSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWA1</accession>
    <name>A0ABR3BWA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dicer-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615378.1">
        <property type="nucleotide sequence ID" value="XM_066756601.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988908"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="9">
        <location>
            <begin position="35"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="494"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="694"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="971" mass="109284" checksum="9EC2CBDC0E10C9D0" modified="2025-10-08" version="1">MAGESPSIIADNSADTRAPTTFTSPNGTVLTFQSAGNHLSSWLQTIGHTPDYSMEDVLPEGYVPPPLSKKAAKKAAQGDANVYAGPPSGSMRVCTVNLPFYGPIRSTPWANKALAKQSASFEAVKELHKHGEVDDNFQATPLRPKKKRDTKGTKSKCHDTWKIKKAVIRDQLPRPTGGVGHGQYDYQTTPEFWSTCPPFNPRSLHASILQLSPAGEGKYDHPECRMMCMLTSKPLPVFKKSDQVEVRMAVGEQPPLCATMRVINGGKMDTFYSGKLDQALVFTEKLMRAELQKVFRTDLRKVKWLLLPLRREYVPPTKEELVTGKSASLKLDDISWKEVDAVTDGALTLPFTFDDYHALKREIVDSLATAPSEMSRRSYILDVRRDLHPLSPHPDFPDKTICDILKEGNVTLPQLTEPSQPILEVSPVNLAKTGSYISTAAMAAGERPRQFLVPEFEHRHCIPASVFRTCTVIPYFIFHLESMLIAEEMSAKEFNSILDPELALQAITAAEGLNIPRWTYERLEILGDTLLKFITTLHFYLLGGGADSEDDMNKVWQDRHMLISNRTLTANAVKQGLVKYIRNKKFKVKEWTPRDWELDLPPGQFTPKKAMPTSFDGPESRTLGDKVIADIIEAIIGASYVHNKDLDNVIAILHNLMVPLNLFKTWDDVRHVLPPQKAEEPKNPDVPAYISFFKKASYEVLGYKFKDNKKFEDAFSLSPAQQTRKFRERYKMMGNALLDLYVIELLMDDYPDEGPASLSVMKLSRTTEGLRCALAVELGMPDLIIDGDDHSRSELKRATHFMQKAKAQADENLNEGEQGGVHYWEEVVISRVNGSIVEILFGAIFDDCNFSLESTKKIFSERIAPFLAKYCRGSNGFDPHPKAMLTRWMQKKGCQFWNLSAEGPKLNQGVVICHDKEIARECAFTQHVTIRYVCLAALKRLRDENYIEEICNCPSFKKVIPDDEKIFGKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWA4</accession>
    <name>A0ABR3BWA4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prenyltransferase alpha-alpha toroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615388.1">
        <property type="nucleotide sequence ID" value="XM_066756611.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988918"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02890">
        <property type="entry name" value="PTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="8">
        <location>
            <begin position="9"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0252668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="300" mass="33114" checksum="646DD8E60B3E94D8" modified="2025-10-08" version="1">MGRMDMVTSTSGGFKGSTYMNTPNPATSPAHLPSTYTALLCLALLRAPLDRLNIPGLLLFLKSCQAEDGSFSPLPAEPYLSEGFQSDARMAYIASVISHMIRDLSGIHIPKLKEWIQKCKTWEGGYASRPGVIEAQGGTTYCSLAALSLISDFDNSRSPLNDRIFQTDILRWLVSRQLGGFQGRPGKLEDVCYSFWCGGALSVLGRDLIDHDANKAFLLSAQSPLGGFGKEPEDYPDPYHSYLALAALSISLNRFGEDKENSFGLKALNVRWNVSAETADWLQTEITRVKEQQERYNDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWP0</accession>
    <name>A0ABR3BWP0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615525.1">
        <property type="nucleotide sequence ID" value="XM_066756748.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989055"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="123" mass="13777" checksum="F1D45BCFC7DEF1E4" modified="2025-10-08" version="1">MADVEMNGKSKDLSWAAKSVEGWNIFVTGLHEEATEEDVQDFFADFGSIKQVSMPLNRRTGYVMGYAIIEYNDRENAERAIAEADGTTFLEQTIHVTFAFAKAPQGGAQRREGKGRELSPDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWX7</accession>
    <name>A0ABR3BWX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Solute carrier family 39 (Zinc transporter), member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615619.1">
        <property type="nucleotide sequence ID" value="XM_066756842.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989149"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045162830" description="Solute carrier family 39 (Zinc transporter), member 7" evidence="7">
        <location>
            <begin position="24"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="42335" checksum="D027C94BC2A570C1" modified="2025-10-08" version="1">MLSTKSVAILSALTLGAVVLAGAYDGKNQNFFEARAKQVEGISMKKVFATLFPFESPAWNSILATFYISSIPNFILLAVPASLDLTSLNTMISFATGGLLGDVFLHLVPHAFFGEGHEVGRSLVVEEKRNIVIGGAIFLGFACFFVLDKTMRVLSSSAGREGSHHHSHSHSHSHTHVSSGRSSSIETEKENELRQRKTPVIDSASADSEAASASQDEKAVKETNPSLKLSAYLNLFGDFTHNITDGLAMAASFYSSPALGAVTTIATFCHEIPHEIADYSILIKSGFTKSQAMGSQFFTAVGAFVGTFLGIWIAETSGAGNAGAHGEGICLDIREGLFGTSVAGGELVIPMTAGGFLYIASVSVIPELLEESRSGKQALKEYAAMAFGVFCMGVIAWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWZ6</accession>
    <name>A0ABR3BWZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD binding dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615354.1">
        <property type="nucleotide sequence ID" value="XM_066756577.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988884"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08635">
        <property type="entry name" value="ox_reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="60"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="2">
        <location>
            <begin position="220"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49659" checksum="4261DFFCD932E149" modified="2025-10-08" version="1">MLPRTMTLFTGMRAKVPSCALRTQITLIERPTTRGALLRGSRSISILSHDKAVQNGGDFHALMIGAGFAMFGTPEGPWNISSRLEKRLGPRLKVDAVIDINGPRAETALTEKRKSFVHEAYANTVVLPDVEEFKRRISIGEAQEPRAIFVATPPIFRGGLGSQNNLEIKLNELFPNAAIFLEKPVATGVPAEQSIGEAKAVGAMLATQHNAPVSVGYVLRYLNAVREMKKIIEENNLTIMATNARYVTAYELAIKTDWWNKSIMQGPIIEQGTHICDLSRYFGGDVNVETICAHALEAHEKPGQLSKRNFDESVIPDDLRIPRATSASWKYESGAVGTMLHATALHGKDYAIELEVYADGYQLILSDPFGTPALHVRKPGSDVLEVYPTPGDDPYQSEIDVFIDAIEGKPDAKILCGYEDAAKTYEMTWAIRNSSEEWTRKLNRRYGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX25</accession>
    <name>A0ABR3BX25_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615384.1">
        <property type="nucleotide sequence ID" value="XM_066756607.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988914"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="32805" checksum="FC90689C70D4E709" modified="2025-10-08" version="1">MSSSHSLARTVFGTDALTVNKLFDVSGWVAVVTGGGTGLGLITAGALAQNGCKVYITGRRFELLEEAAKTAAPSQGHGSIIPVQADMSTKEGIAKLKEVIESNEKWINVLINNHGVSLPSAQIDEVEQTPAALSKKMFEDETFENWTNGYRINTASYYFTSFAFLPLLSAAKTVGNFPEPGNIVNLSSMSGITKTSQRGQFSYNANKAATISLSHQLATEFARRDLGVRVNVVCPGYFPSGMTPVEDKYQSAANPEFKQKWGTPLARPGNAMDYAQCIFGLITNQYVTGTELIIDGGWLLVQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX66</accession>
    <name>A0ABR3BX66_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615697.1">
        <property type="nucleotide sequence ID" value="XM_066756920.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989228"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="541" mass="60651" checksum="C9DB91DAE696DC3C" modified="2025-10-08" version="1">MPSIRGFRAHIEPDDVSGHSNPDLEDNHGCNNDLHIDPVEGEALENVSEGAVLLGKTFKPMEHDHRPRRGRGWVTISGFSLPKPLLYLLAVPPLLILINLVASTYSAPKPYSHYRHPTLTNGSHSFHPTVLLLSLDGFRSSYLSTHAHLLPNLLSLSSSSKWGLRAESMQPVFPTLTFPNHWSLMTGLYPSSHGIVANDFWDPLFDGEQNKGAQFVYTEESKSWDSRWWWGEPIWEVVEKVGRKAAIIMWPGPPVTRTGTSPSYFVPYRNLPPSSKLSQIFAFLDQPLPTRPEFIASYFPEIDQSAHRYGPDAAQVEEKLGMMDEMVGGLLRGLEDRNLSGVVDLLIVSDHGMTSTSNERIIYLDDILGDDGVEAIEHKDGWPSVGLRFSSTFNHSLYLERLLSAAEASNGTFAVYTPDTMPQRWHFTGGRRIAPIYVVPDIGWAVTDHHEHEILFQGDYQPRGNHGYDNKYPDMQAIFLAHGPLARMLKNVGKGFVSHDPPVLHSFKNLEIFSLITRLLNLRDVEPGHNGTVGFWEGLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXR5</accession>
    <name>A0ABR3BXR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614823.1">
        <property type="nucleotide sequence ID" value="XM_066757354.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989675"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19093">
        <property type="entry name" value="AKR_AtPLR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="330" mass="36670" checksum="F26C151A5041FFFA" modified="2025-10-08" version="1">MTTAATSLLSKHVTIAGVQVPPMAIGTWSWGDKTWGYEPKDFENVKEAWCASVRAGLTFFDTAEAYGNGESERIIGRLIQEETTEEDKARLYIATKFLPFPSRNGFFFFNPPVVEHLKASLERLGLDSVPLYQLHSSISLNSHEKIASGLAQCVKLGLAKAIGVSNFSKDELIKMSDLLEKHGVKIASNQIEFSLLRQLPEQNGLLEEMKKRHITCLAYSPLAMGRLTGKYNASNPIPSGRRFSSQYSWEQLEPLISELGSLATKYEVTHSAVALNWVMSKGAIPLGGSRNKSQAEQNAKAVTFKLTDEEFQRLSSLGFSGKNTWFWQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYL5</accession>
    <name>A0ABR3BYL5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ergosterol biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_102308</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615635.1">
        <property type="nucleotide sequence ID" value="XM_066756858.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989166"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0252915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14869" checksum="DBD64D02DF7D033F" modified="2025-10-08" version="1">MSFLPSATTGILPYWLLLTSVAGTYNAVQNYFVIWQSKEVYAGKADEMTFLAGRIFGAWTLLASLIRGMASYNIYDPLVYNLGIGTYALATFHFTTELLVFKSVKPNRASIGPLIVGWTGLIWMLTQREHYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYV3</accession>
    <name>A0ABR3BYV3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066755508.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987804"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="89" mass="10187" checksum="6C5407CD94BC3DD5" modified="2025-10-08" version="1">MLKSSPSLAQGSSLISYFIYISFFVSYFERSILGTILEAERTCSSRREIIHNIACIFTCLDAEKQLNWLVHFSYPPNKPKPSQKHLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ90</accession>
    <name>A0ABR3BZ90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin nsp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066755628.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987927"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="368"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1094"/>
            <end position="1171"/>
        </location>
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            <end position="1500"/>
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            <begin position="32"/>
            <end position="42"/>
        </location>
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            <begin position="97"/>
            <end position="107"/>
        </location>
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            <begin position="183"/>
            <end position="210"/>
        </location>
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            <begin position="281"/>
            <end position="292"/>
        </location>
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        </location>
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            <end position="443"/>
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            <end position="575"/>
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        </location>
    </feature>
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            <end position="752"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="1159"/>
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            <end position="1245"/>
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            <end position="1259"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1260"/>
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        </location>
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        </location>
    </feature>
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            <begin position="1383"/>
            <end position="1404"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="1405"/>
            <end position="1420"/>
        </location>
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            <begin position="1422"/>
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        </location>
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        <location>
            <begin position="1491"/>
            <end position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL0253693.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1500" mass="155563" checksum="F5A94616FA451CAA" modified="2025-10-08" version="1">MSELHRALSGAHRPNSNPRIHRHSSPYKRPLGQSNLHPSSTMGDLASLAGSDTSPTKKPIPSSRVQNLASGGGLTRSGSEPSLLSGIKSMFTRPLQWLSTPGKTSGGSKRDSLSSFGHELEDPASPSERREGKRIRRHSPEPRMNRSNDPMNDYTPEHQFEIQGRAVSGFMLPPLSPHVTLKPKSSFSNDKASPKRPTNFSRPLISSQSMPYLDPPHNVLRSSASGQAVASPKKTGPLTRSKRVDLATLVDDDAGFQEDGLDRYEKGKEKEIWSPWKSKYAGANGASSTAAAQRNITPRRKTFAPTLEDGDYAHPTASPFRGLPAASPRPRQPSPIGLARSATATNLRRHASAASDISMASAGGTVRSTSIKNLRDLEISSLLGGSMSRNKDDDRMSVEGDSIRRKEGSVLDWFMHDQWDKPKSPASAATSNRLGSSVSTTTPAPMRRGQMVWNQDDKVFMRESELKASQKPAPVHKNEAERILYTLETMRKTPLTDARKGDIPPLLGQSSRTLRRSINVPLATAAAGESARQRKDKERFGDLGVSVMISPYGRRRVADREAREVRKHSRLESQEYRPSPIPSGARSETASQTFSAQMGSLAPKEPSKEPSSSPPPAPTPRRSSRLKRTSAVEETTPKANRRSTRRGPSKQPAPVHEDEPVARSSRSTRHTRKATVEPSISPTPPPAPPSVPSIIATAPSPGGPSTSDTYQPRAGNQMPRGGSSLRARSDTSKRTHQSAASYSRSQTPTSGRYSAKDEDLPDMEELEQASKIALPSFSGISFAGLKPSSDENVSNNTVQSKSVVTPAAPLPPLSLPRAGGPLARLGVSSTRPRASSPLATGSIVAAPDSPPAMPLPKKSDSSSPANGIFSLSGGTAETSASLNPVGSTTPAGKPPAVSSFFSKPPTSTEAANKQSFSFAEASSKTSDETTSGAGKAEAGGIPNFFGSTAVSSASSTKQSSPVPVPALDFGIQKKDNVEKAPPAALPPPITSASASPAPVFSFGVSVNGKKEGDEKKTTDSAAPSFSFGGKEPEVAKKDTTAPSGGFSFGAKGDSAPSGGFSFGKSKDDSPAPASAVPSFSFSASKPAAADSVAKSPFSFGAPVSDKPKSDEPSKPAFTFGQSNSSSTASDSVNPSITPSKPAFSFGAPAPSSNTPTSKPAFTFGASGSTTPVTTPITAVANKDTAGSGVTASNTAPAFGGFSFGSQGVNKAEDKKDAPANPFGGASNNNSTFTLGGPANKSSTVNGTSSPFGTTPTTVTNADASKNPFDNRSGSNVLTTPAFTFGAPSSASLKPANAGAFGSNASTAGQPFVFGGSSSDGGSTPAPLNTFKTDNAPKPSTPSFAFGSGNNGTPASNPFNASTTPASNPFGQQQDQKANAPASFAFGATNNPTAAPASNSSFSFGQPMNANPAASASTFSFGQPAQQQPSTPAAPSFSFGQTTAQSQPAAAFSFGAPAGDASRFKSPTPGPEGGFSLGVATNEAAPASPGGRRVKGLPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZC5</accession>
    <name>A0ABR3BZC5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615951.1">
        <property type="nucleotide sequence ID" value="XM_066755665.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987964"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="65321" checksum="E7A9699C7D4C7718" modified="2025-10-08" version="1">MDQVHVARNQVNTLLQSIKDFISNASESATYHAPIIDWQHPEPYQQSTITGLKKFLSAVETERNYLEALASSDAPPKELATNLPHLTAVWEEVKRADWPLGCISQVLECSDGSQVKVDVVARGGEEWIKVNTMKESRLMAEFREQDSYCNSDYSDYDSDTPAEKPNGQPVYPGLTNSAIEQVTSMIQSARSYPRLPHLPPPKVKYILNRLEGNPEGGYADPRVNGTFEVIRSLGAQLVLASDIRPLPKQLTPPLPRPTSNVLLDLSVVVALCCDSTHFPLPNSQQELEARFRPLQLASGQLSLAPHVPVTKDLRDQLQWEMQHPLIQEMQERLSLVDGTLEFWVTEEVKSRLPKIVEVIGGENEKRRAQAMFTGFEDFWAGSRWKGSEGVLGNMRVRVISKTDWDLVDLHQIQHSPFRRGFASVCQMMLAIVERQTSASVLPPPPPPPKANKTTSNRSARRPQPGITMASRLPSAHTLRTFLAGIKSSMTVLTNNRGAVGKVIREMGVNEGLAYGMEDVKGEAVVWVVNPSSLSEWRRKEVEAKNEALKERLGLGKGDEPSSEAQSIPSSSERDTRSPSMRTTGPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZK4</accession>
    <name>A0ABR3BZK4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616038.1">
        <property type="nucleotide sequence ID" value="XM_066755752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988052"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0253817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="85" mass="9470" checksum="A12EA1C2D41135CC" modified="2025-10-08" version="1">MARRCHSSLKGMAKISCSMTSAETARILEETGEGGNLVEVVVVLGEDMMTSNDLHKSIHAREVDLIYEVVDERSESLVEIWFRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZQ2</accession>
    <name>A0ABR3BZQ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616091.1">
        <property type="nucleotide sequence ID" value="XM_066755805.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988106"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0253870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="545" mass="61250" checksum="8630107361BD3CA4" modified="2025-10-08" version="1">MQYPRVNQYPDDVFVRLPAYYADHCGPGWYPELQCPQKAHLAVQYRSALRKDVYIHLKAFFIPGIKEELGKQGIREIPHSFGAERGLEFTKCQSLRHLPGHVITTIHCQHRAEDVLIIANRNSHLLVSSSSELKAKYPEIDSRGFNTASARDILLVHEELPLTPTYIPTIAPSHPAHLPSSQPSRWNAVGYARDAFVNKRKLTEYDPNLYSLAYNHLLDSHDKRYLHSLGCEGMESCGAHDLREAPSPRKRRLLAHNPLPSSLHRYVDIPELRYDDSQISSHLGEFVAPSVLPYGPKNPYTRSQIASADYSQRDSTLRSTLWSTQQPPMKKIKKRKSLFKTKHALGMGTGTYVWDRTVPTGGTVLRGVNARRKITSLAKRLCALTETSKNQTEGETHVSGPSFPSADAVESLRQIVLGNGGGAEPLVTAETLTFNEQVQAEPGLELTSGNLPDWNRKVIANWIKIHGHNLVPCLGPAPSFWVHSDSRAVPPHHSFTVTFNFLRHIFTPISVKQTISFRAVWTIDSEDQRKLLGLEKRWIMNGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZU8</accession>
    <name>A0ABR3BZU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 12">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_101285</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 12"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616128.1">
        <property type="nucleotide sequence ID" value="XM_066755842.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988143"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01033">
        <property type="entry name" value="LeuB_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="7"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0253907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="373" mass="39844" checksum="CC7BED395D7D253C" modified="2025-10-08" version="1">MADKTFKITILPGDGIGPEVVAEAVRVLETIVNHSDLKLDLKSYDFGGAAIDNHGVPLPDETLNACKEADAVLMGSVGGPKWGVGPVRPEQGILKLRKELGLYANIRPANFASESLLKQSPLKEDIARGTDIIVLRELIGGIYFGERQETNDEGVAWDQCIYSKPEIERITRVAAQIALAAEPPLPITSVDKANVLATSRLWRKTVTELMAKEYPQLKLEHQLVDSAAMIMIANPKKLNGVLLTENMFGDILSDESSVIPGSLGLLPSASLAGAPDPKSTTMGLYEPIHGSAPDIAGQGIANPIGTILSAAMMLRYSLGKGKEAALIEQAVQKVLDSNESGGFDYRTRDLGGQRSTKEVGDKVVEVLKGLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C047</accession>
    <name>A0ABR3C047_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615736.1">
        <property type="nucleotide sequence ID" value="XM_066755450.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987745"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="77"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="290" mass="31040" checksum="1B6A8A7FEADF4DDE" modified="2025-10-08" version="1">MSSFSRLVRFIPKSSSTPLIGEPVNADLDVGLAAYESKPIEVEVFSGTSVLKPGEKTGKKEIVERLLSPLAQSEVGTIRCIGLNYVNHAKEVNLPMPDIPTLFMKPSTSLANPFPSPTIIPRAFVASNSADFESEVAFVIGKDAKNVSEEKALDYVLGFTAANDISSREAQFAQSQWCYSKSFDGACPIGPAIVSKDQAKNLSDVKIEGSLNGKTVQSSQLDDLIFSVPKIVSFLSQGTTLPAGTIIITGTPAGVGWTSTPRITLKDGDEFRVFVSHGVGTLINKIVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0G5</accession>
    <name>A0ABR3C0G5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_101025</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615871.1">
        <property type="nucleotide sequence ID" value="XM_066755585.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987883"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="68"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0253650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="463" mass="50860" checksum="F5556D7122A0B7D5" modified="2025-10-08" version="1">MAANISLQPTSMRDVTKMERIGVHSHIHGLGLDSNLEPRASSQGMIGQGKARKAAGVILKMVQEGRIAGRAILMAGPPSTGKTALAMAMTQTLGSDVPFVMLTASEVFSLEISKTESLTQAFRRAIGVRIKEETELIEGEVVEIQVDRSVTGATKTGRLTLKTTDMETVYDLGSKMIDQLQKEKVLAGDVVSIDKASGRISKLGRSFGRAKDYDAMGADTRFVACPDGELQTRKEVVHTVSLHEIDVINSRTQGFLALFAGDTGEIKPELRAQINGKVAEWREEGKAEIVPGVLFIDEVHMLDIECFSFLNRAMENELAPLVVMASNRGITRIRGTKYKSPHGIPADLLDRMLIISTNKYEEDEMREIVKIRAEEEDVRLSPAALDLLATMGIQTSLRYALNLIAPSSLLAQRRKSPQADVEDVRMAYKYFCDVERSAQYAKETSGMMFGETEEINGGMEIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0M9</accession>
    <name>A0ABR3C0M9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616205.1">
        <property type="nucleotide sequence ID" value="XM_066755919.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988221"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="367" mass="39750" checksum="53B5BDA9F819ADD6" modified="2025-10-08" version="1">MPSVLSPNNTVSRSYAPLIDETNPPITTSTSKTVPYNGPAMYGQPDLPLAVVASSSTGFDDLQKAGMSMRSDSEEALSPSTSRKGKERAKTPTFDGDLGEVRRGSYKGKERVWDIEQGIYSEEQLASENSCYPPTNEAEEEERRIQEHLTRLAARDMARRRAARESKQLPTPTAASAPPQSSFSISSAARRPFSLFSTSSKRGSLLGLDGGWIGKKDADVGELPMARPRSQGEQYMNPYEAQPTYSPAPKVSDSHGSISMQSPFADPSPPPPAATDLSVYKRPSLVSASSGSPHTSYRSPLISPISPTDETGFAYGGPTWRGGQAVQQQEEVARRGPDRWWHALCAWGDDLDGGHDVPEAGRTNPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0R0</accession>
    <name>A0ABR3C0R0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615976.1">
        <property type="nucleotide sequence ID" value="XM_066755690.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987989"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="19"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="344" mass="37574" checksum="A95CA743CC8B4A67" modified="2025-10-08" version="1">MTSPQKNVQIVLNERPQKGPVTDTTFKSKTVDVPELKDGEILARVDYASVDPTMRGWVNEGRSYLPPVKIGAPMRANGLGTILASKAEGFKAGDKVLGLLNWQEYYVGSTDGLSKRETPEGAKDVDHLGLFGMTGLTAYFGMTEVGKVKDGDHVVISGAAGAVGLVATQIALAHPKCKVTVIAGSKEKLDYLKKLGAHNTLNYKDDDFKEQFKKVGLIDVYFDNVGGKILDMALAQLNPFARIVACGAISQYNATVPDPIYNYFNLISMKATMRGFIVFQFADRYPEGIKYLSDLVKKGKMEFNYHVIDGLDSCVQALREMFEGKNLGKTVVRVSNEAVKGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C194</accession>
    <name>A0ABR3C194_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="10">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_101313</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="10"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616156.1">
        <property type="nucleotide sequence ID" value="XM_066755870.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988171"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="12">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="13">
        <location>
            <begin position="130"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="14">
        <location>
            <begin position="254"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0253935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="397" mass="43151" checksum="E3FF35DFE975BED5" modified="2025-10-08" version="1">MTAVSVNGNGPVTELAPGHFLFTSESVGEGHPDKICDQVSDAILDACLAEDPFSKVACETAAKTGMIMVFGEITTRAQIDYQKVVRDTIKKIGYDSSDKGFDYKTCNVLVAIEQQSPDIAQGLDHGALEKIGAGDQGIMFGYATDETPEMMPLTIMLAHKLNAAMATARRDGSLGWLRPDSKTQVTVEYKKGEDGAMIPLRVDTVVISTQHAEEITTEKLREEILEKIIKKVIPKNLLDDRVIYHIQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDWSKVDRSAAYTARWIAKSLVAAGLARRALVQLSYAIGVAEPLSIFVDTYGTGKKSDAELVEIIRQNFDLRPGLIVQALNLQQPQYLKTAAYGHFGNPAYSWEQPKQLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1K3</accession>
    <name>A0ABR3C1K3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616442.1">
        <property type="nucleotide sequence ID" value="XM_066756156.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988460"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="173"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0254221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="334" mass="36378" checksum="C703D57E6A4FFFD6" modified="2025-10-08" version="1">MAFRATLGLSHSLSRAQSVSMASIRPSHAFTPFVPCTTGLSRSLLTSSPSTIRFPSVPPSSSISNFLTKRSFTSSTKSLIRSTYFPRGGRSGGNGYGYGGGGPQGPWAWFTRLRRRIDRIPTMTLVYGLIGINGAVFLLWQYALSSAQRFRDPSLLYFLRNNFILNEVNVFSGRIWTLVTSAFSHSNGTHIFVNCLGLYFLAPAAASIMGSASFLGLYLGAGVFSSLVSLGYHRFSQHRWWGSEGASGAIYACLAYYGALFPNSQVLLFFVIPMPVWVAIGGIFAWDFYSAVQRPNSGTDSAGHLGGIVYGLAAAMALKRGGFMRMMRGGRPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C216</accession>
    <name>A0ABR3C216_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_100957</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615805.1">
        <property type="nucleotide sequence ID" value="XM_066755519.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987815"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="10">
        <location>
            <begin position="762"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0253584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="965" mass="108160" checksum="AFC6BD6D467EE7D3" modified="2025-10-08" version="1">MPMYGNESTSAPKPLFDMGKFLCEEKFVRFVERMPTKLDGMIRLFDRGDYYSAHGADAIFIANEVYRTTNVLKYLGSGKPSSSSGSYARGLPSVTISMALTKAFLREALTTKQMRIEIYAPTGGVAPGSRKDHSKWEISKTASPGNLSQVEDLLFSDKDLTANAVSMAIRVVVKDGVNTVGVGFVDVQEKVVGVSEFVDDENFSNTESLLIQLGVKECILQSDEKRPELAKLRMLVEWCGVIVTDRKSSEFQTKNVEQDLNRLLDESHAGAALPEFDLKIAMSALSALINYLSLLSDLSLHGQLRLHRHDLSQYMKLDASALKALNLMPNPQELGGNRNMSIYGLLNRCKTSQGTRLLGRWLKQPLVNRHEIIQRQTMVEVFVEDSVNRQSIQTKYLKQMPDFHRISKKFHKRVAGLEDVVRVYQAVQLMPGLQEILENANTPEPGARDLIEEIWLKPLREHIEKLGNYSSMVEDTIDLDELANHNYVILPTIDEDLQRHRDELLDVRDQLDDEHRRVGNDLGLDIDKKLHLENHQVYKYSFRITKAEASLIRNKKEYIDLATQKSGTIFTTKTLKALSEEYFRLQELYEKQQRHLVKEVVSIAASYTPVLEMLDNLIAAVDVIVSMAHVSSEAPIPYVKPILTEKGTGDIVVLGARHPCLEVQDDIFFIPNDHEMRKGDSEFIILTGPNMGGKSTYIRQIGVIALMAQVGCFVPATEAQLPIFDCILARVGAGDNQLKGVSTFMAEMLETATILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIAEKIHCFCLFATHFHELTTLSEKNPHVKNLHVEALVKDKDGEAGGKERDITLLYQVKEGICDQSFGIHVAELANFPESVVKLAKRKAEELEDFGDNQTPAFSSKFPKTEIDAGTDIVKEFLDTWKSRVSAAGSGEGADAEMAMSEDEMVQLLKNTAEEFKDRLEGNEWVKSLMSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C2S4</accession>
    <name>A0ABR3C2S4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroES</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616282.1">
        <property type="nucleotide sequence ID" value="XM_066755996.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988298"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11173" checksum="0BA1931EC244EA66" modified="2025-10-08" version="1">MAATFKNIKALQPLLDRVLVQRFKPETKTASGIFLPSSTTQSPLPEATVIAVGPGAPNKEGAVIPVSVKPGDRVLLPGWGGSPIKVGEEEFHLFKDAEILAKINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3M6</accession>
    <name>A0ABR3C3M6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin fusion degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616504.1">
        <property type="nucleotide sequence ID" value="XM_066754603.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986881"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="48"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="5">
        <location>
            <begin position="149"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="51890" checksum="588E3ABB09FC130A" modified="2025-10-08" version="1">MNHGYDSEDEFDSYAAPPPLPGGPASILSHLMGGGFGGFHSAPPPSAYDDYFKAYSTAVMGGRERPEVMYGGKIIMPPSALARLSALDIPSPWTFQLRNPRSPTQHTTHAGVLEFIAEEGIVHLPAWMMKRLNLEEGDPVRLTGAKLPKGKMVKIQAQSTDFLQVSDPKSVLESALRFYSTLSPNDIIEITYNSLTFEFLIMSVVPEGPGISVIDTDLEVDFATPKGYVEPPRPEPKPIPTMADKLNIDLSSNEPTGSGAASVSGGSRPGTSMGTQTPVESFTGVGQSLSGKKVKGKGLAKKIEEVDSSSKINRADGPRIINTSSLSSANTQVPSALILPEGKFFFGFKYIPYDPSKAPKPSLADQQKVEQQPFGGEGNTLKSGKRVGGGEGKGKGKEKAAEEEKEDPWAKLGSGNTLKRTTATAASSSSNSVPASAPQKEFETRKATEQEIIDATMLDEDDFMFEDEEDDEDDVIEIDSDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3S6</accession>
    <name>A0ABR3C3S6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616557.1">
        <property type="nucleotide sequence ID" value="XM_066754656.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986935"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="453" mass="48165" checksum="4331FB4ABEEA51A0" modified="2025-10-08" version="1">MAVESPPQMQKSADPNARLTDTLCTSLRRRQIVGSLNVALATAALIQSIVRSAKYNTIDELLALIKAVGRKLTEANPKELAASNIIRRILRLIREEYRAAAAAHVSSAPSSIPSTPLIGPSTPGLNAPLDHYLSAAQSAAADAQYFPTHIQMSRQTSLSNFVAMRHSRAQMERSGALSGGGAEGYSAITANLFATPPANGHGRGSPGVSTPGAGVDSDEFMKHSAKLKPLLIQAIEEVVGELETTHEDVAKGAREHIHSSEIILTMGHSRTVEAFLKQAYKDRKFTVIIAESAPSYLGHSLASSLSPSGIPTLLIPDSSIHALLPRVTKVILGAHSVLANGGLFALSGSLACALAAKTHSKPVVVTTGQFKFAPAWNLYHEYGAVDFQGPGAVIGEHGKGGGGGVEGVEVVDPYYDYIRPELVNLFVTNEGDHPPSYIYRLIREAYDDEDVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3X8</accession>
    <name>A0ABR3C3X8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616617.1">
        <property type="nucleotide sequence ID" value="XM_066754716.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986997"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="619" mass="67278" checksum="391F6327FE0547A7" modified="2025-10-08" version="1">MMEKMKPKNTYTYTSLTRRIRQAAQSVGDYFNDETMSQYPILVFLSNKLDRPPSVLAHSFLLLLLSGVLLNPYHLSGTIVNTLGILWPTWLTVAHISSLHVSSNAKDDSKSQFGIRARVRTDRKDKEWSSQTKRLIDYWILYSFSTLVESAFAEDTLLDLIPLWWAFKVLAIVWVSFGLSLGDVGAVGASSRAKEKIRPRPLKLRTNSNLTGIPSPAVVKTSQTSYGDIDSSLSSSSSPSHPPSSSSTAANTSDTYPYPGITTGTRAEADRGPTQSTSQLQSLRDELGEISTVLSRTPENIRRRRRGAGRRGGVAESASVMNEDGSELFGLSKVDRQSEPDSHSGSDSYPDSDSNSDPKSASDSGSESDSGSKSGSNSDSDSDSDSNSEANSASGPNSPSNSSLPSPSSPPAPSPYLDTSTSTSTIPRHLIISSKADIASSAFVENSNNHVRLPPDTQLDELALRGLKTIELEVGQEEEEEKQKGDEQLKLGFWNEWEKAEKEKDMRTDPERPHAVFPPLDDKPNINPHPHPHPHPNLNPNPTNPTTITPNHPSRSTLPPPQTPIISNPTNPPVATLSQNQNPNQLGEKSEGRITRLTLDDLLALENDDPSSLPASITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C428</accession>
    <name>A0ABR3C428_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616670.1">
        <property type="nucleotide sequence ID" value="XM_066754769.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987055"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1012" mass="112166" checksum="E3FB009E32A57508" modified="2025-10-08" version="1">MLPTTCQAYGRRLASVASISSLSTSPALPAESSRQAFLRAIASRPTHTDTAVLSRTGTRHQSTTPISGSKVRSMSSDAAATAWATGEDDCTGRYSNQRSWGKFSGPTGSDPIGPLPANKLKSFQPDLDVHDDFSLHPLPKEPSSEWLDSWLQSYDLAQLPPSPLPPLETFRGLILSHPLLALLTLPKLPHSDLLAIRHAEVRALIWGVTKVTRDIPDVLLRTNPEDCAKAIRVLRAIIYALPSCKNSSDPFMGRYLRGKILRSLLVLCYRLKCPRVAKIIFQERLREQLATDSDPPILPFEAIAQDLAMAREWQVIVELFSPETFPHRYFTSELIALFMQAHFGIHQSSKVPRIFELHDVLDLEPSMNAMNHLVQAFLHMGDLQTAKAIAKEANVTGGVDYASQQLAILWGYRSLGRDEDLEIKVLEDIERLELPLEARLLHALIRLRLDADEILKAEELLQKFNLTEWGVEGGGNVTPTSKTGSLLFVVASRKGDLKEVKRIWDKMCTRSEVVDDEAVTTLLRALFEQGKSDDALAVLQSALPDTPSMDSKWKLPLGVKPDIRAMNFVLGALSRERGIPGLELAMSLIHSFGIKPNNLTLKTIIDFSRSALRHSPYDLATLVTRIMESTPTLPPSQSLLDSILADAVSSSARTRNRDASSSEFSPSHSEDTFHPTAGLVLSPPLYSALSDIIESLESIDSRSSSRSLANRLRYDAMTNADISGVPSARIVWNALIARGFNPDHRHVVALMQGYADAGHMYEVQDLLILASQIGIKTSKDMLMVLLTGWGKRRKPRHARKAYERIKSMGEKEGEGLDLLAVTAMIQAYSFAGKYKEAAQLCHADLRCLGVKLDEKAVVVAAQALRSDGDLRGALGVMEANGKALGVAGRKITRGIKLYARKQLLKGLDKEQQQDMNEVVQLAEQMIREDELARPITLKKWNRLGAPTRKRLENAWSGIVSEGQNPDGVRGRRTRMEKRAIIGRGKGVGFRALEARRERRRFVTKRRKNSVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C474</accession>
    <name>A0ABR3C474_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616707.1">
        <property type="nucleotide sequence ID" value="XM_066754806.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987092"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="413" mass="44700" checksum="6FD02AD2944EA5CB" modified="2025-10-08" version="1">MFPMSPALSQPHRTAGQQDTLLEQKKLSLPGIIILLTKCLLSPLLVFALIITLISLLLPTVEHHGTTFYSIQPVGYARKVTICSLPIGSTSTPLSALNASALAPIGDIEQKLERTSTGNNVVNTIKVIVQSGNVTLEKWLGIDGPSIFVGALKICSRISANEPIVCTSSRETAYHAAFLPLSLGMVLTALPSSLSSPILLLISGILSLISSLIFIASLISWHVPRRPPLSRRKSHVEAAPHRPDYPTDSDSVRPLIHEERADDAGKSVVRVKWGNGPHPAFFCTVLSALGVAGGAMVELRDAGNANIFVTSLTCISVLSTCHRFLPGGMVNSPFQALYEPRSCSRRDSPLSKTRKPSKRAKCPKRHLSREIMVADKPAMAEFSETPMTERLMEMKVLGETHLELGERRATGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4B2</accession>
    <name>A0ABR3C4B2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaperone DnaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100271</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616744.1">
        <property type="nucleotide sequence ID" value="XM_066754843.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987129"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="646"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="670" mass="71802" checksum="99E09AB27D481F3F" modified="2025-10-08" version="1">MLSLSRTLRSTQAINPLRSVARTTSPLLASKRFNSGKVSGPVIGIDLGTTNSCVSIFEGGAPKVLENSEGARTTPSVVAFTKDGERLVGQPARRQAVVNGENTIFATKRLIGRKFKDAEVQKDIKNVPYKIVAHTNGDAWVEARGEKYSPSQIGAFVVNKMKDTASAYLGKPVKHAVITVPAYFNDSQRQATKDAGSIAGLEVLRVINEPTAAALAYGLDKSESSVIAVYDLGGGTFDISILEMQKGVFEVKSTNGDTHLGGEDFDIALVNHILAEFKKETGIDVSGDRMAIQRIREAAEKAKCELSSAGATDISLPYITATAEGPQHINLNLTRARFESIVKPLVDRTIEPCKKALSDAGVKASEINDVILVGGMSRMPKVIETVKSTFGREPSKGVNPDEAVAIGASIQAGVLAGNVTDILLLDVTPLSLGIETLGGVFTRLINRNTTIPTKKSQTFSTAADGQTAIQVKVYQGERELVRDNKLLGDFQLTGLPPAPKGVPQIQITFDIDADGIVNVSAIDKATNREQSMTIASSSGLSDNEIEQMVADSEKYAEADKARRLVIEEANKGESFVVDTEKSMTEFEAQLDAAEREKVKKLLAELREIAAKGAAGDASVKADDIRQALDAAQQASLGLFQKVYEKRNAESRDNNTESSESSQSTEGEKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4H5</accession>
    <name>A0ABR3C4H5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="1">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="1">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616807.1">
        <property type="nucleotide sequence ID" value="XM_066754906.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987192"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="3">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="154" mass="15663" checksum="CA4C2B4BA8E85394" modified="2025-10-08" version="1">MVKAVAVLKGDSPVTGVITFTQEKEGAPVTVSGDIKNLDANAERGFHVHEFGDNTNGCTSAGPHFNPHGKNHGAPSDSERHVGDLGNVKTDGNGVASVNISDKSLSLFGPYSIIGRTIVVHAGTDDFGKGGNPESLKTGNAGARAACGVIGISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4J2</accession>
    <name>A0ABR3C4J2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dihydroceramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616828.1">
        <property type="nucleotide sequence ID" value="XM_066754927.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987214"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33341" checksum="EB84064C6911E157" modified="2025-10-08" version="1">MGAFDKLRGDQVSSGFWGEHTSTIDWCETNYSHSPYIAEFVNTLSNLPSFLIGLYGCYSVLKNGLRRRYALCYLGLSLIGLGSFGFHASLRWEWQLMDELPMIYVVSYAAYLVLDTLPGFEPRFGTIGPLILLAWDAFVTISYICLPNPVYHQVAFAAILITATLRTVVLVFDLPPGHPARGTIGEMMAWGIVTFATGFGIWNIDNIFCTELRAIRSMMGPFGVLVEGHAYWHYMTGYGAYLIFTASILLHCLIKDDIKGYQINGRWLPTVIRRPQAANKPESRDWKGSVTPPEKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C501</accession>
    <name>A0ABR3C501_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616713.1">
        <property type="nucleotide sequence ID" value="XM_066754812.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987098"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8092" checksum="CDF0BB242015BC02" modified="2025-10-08" version="1">MSGTQSPSSNKPDPMLPKDAPQMTQADQRPAASGNKPGAAPGENSEGGVSAAALKTAQQSADSLSGEGGKSRKEVETGPGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C504</accession>
    <name>A0ABR3C504_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein transport protein SEC22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_100505</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616975.1">
        <property type="nucleotide sequence ID" value="XM_066755074.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987363"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="15">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="16">
        <location>
            <begin position="144"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0255698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="225" mass="25780" checksum="98239F0EA1229D35" modified="2025-10-08" version="1">MVRSTTIFRVHDALPLAASVDDESTEKALTEYKQQSKLIFRRLNANSEPACSIESGAYTLHYLIVDKVIYMCICDNSYPRKLAFSYLDELSKEFQRSYGDKIDGATRPYAFMGFDTFIGKTTRLYRDSRSLTQGGGPAAGPSSRLDQLNENLKDVTQIMTKNMEDLLWRGDSLDRMSQLSTSLRSESAKYRKAARNINLEALIRKWAPIGGIGFFFILFIWWRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C557</accession>
    <name>A0ABR3C557_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617039.1">
        <property type="nucleotide sequence ID" value="XM_066755138.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987427"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="871" mass="96466" checksum="3586957EC053A476" modified="2025-10-08" version="1">MPFISGPRRAEMDENGERTYFCSWDGCTKKFGTAGHVRRHEKTHIGSTPYSCPYCNKSFGRSDVRAKHVSTMHRGEESRESDGESSAKSRRLSIDSTASSRKLSLSSITTASEVRPLPSVTLPGPSHLFPPLQSAGLPISPSEDSNPGRIPGETQNVLGLDINLQRQQHGLFPSSPSSSNPPSGTTQFIGQSTPGSGFIDPASLNAASSSAIKNLIDIPTDNMLSTTAIPSYPVLTFDPSWEWFGNLFGWGSDTNIDLDVGLQNSMFESNGVGPASSTDTLSAAWLLCATPRGGSPVTGEGIRAQGMADPFGRKDDTPWPNIFKPNVPDRPLTLGGVKASSDTRPPRSGPKSISEASRNAMLSLIYLSHQPHWLMPDIDDFPDDDTLSDFVDLYFEKFHPMFPILHRPTFFEGDTPALLLLSVAAIGATFADLKYRPLAVALCELVRRMIAWMRGSDQRAKFDRHALAAFTLQTALGVVCGSREMFYHAEISRCSLVTTCRRLHLLRGLDTATEELYKREKHPSNEERYRAYLKDEERRRLGWGVYFLDAQMSAMLLIPPIFVVNEARVHPPGDEALWEAPNAEAWASIIAKGEAPDPSFPRPRFLKLLSMCMAGQDGQMVMSDFTVGIVTYTIWRLLMDQRSLQKAIGVGLSENGMDLAICFQTDILDTQPGYLLTRLATSTFPIRSPSYLRLSPAALYHHARLVFTRPGLIQRIKHLSGKYEPDMTQEGSLLWLKTWLADGSEVRKIIWHAGVLNELMAENPRGSIGELIWTFDCALIFWIVLKHAPQQLTSALPVAFFAANWLCITPPEMWIAHGGQITFPLLGASTTWTVSAMLRIFMDRLHKMPWGLAVQYHLVLNKLLEAESEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5X1</accession>
    <name>A0ABR3C5X1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617299.1">
        <property type="nucleotide sequence ID" value="XM_066755398.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987692"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="159"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="161"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="561"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="653"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="774"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0256022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="807" mass="86446" checksum="08DDF710C39BE052" modified="2025-10-08" version="1">MSLPAPQQGHPSSSDGYQEYEQQRQPVTGPSNYGRQAYIPVSSGYATYPPNQAGNGSQPAPILTQPPIPPQPHTFPRSYQSQQTAYMHPYAPDMHQGMPSYSYGADVAPNYQFGSVPAVQQPFLPQQSTQPMTAHAGDIIPFGDDGSKDGDNALNTLEGLQVKHRRRTTPDQLKVLEFWYDINPKPDNQLREQLAAQLGMTKRNVQVWFQNRRAKMKGLAKKEAEEKENRKSPENTEGNSSATEPSLTPLTDSAVPSSHFNLLAPPTSVNMGRRASLANGEAAKIEIFVAKRAAAQKREEVLYNAGGYSAPGGTRSPVLGQAYAARRSSIPYPTPQISGPSASTSPLSPKFSAACRGPSTLHMAAVRNNTRRPSIPGAAQLISSGPFTPPRVVSNQHQTAVQNKGTRELSPIQDHEVYNTYGGEYQPWSGDLPPSMYLPPAEGFHDGRPFSHDSPLPNPAFSFGSAPQGLDAQGIMSIGQMDEKQQQMYMMMQQRDRLGSIASIGTMGTESGTEGGESSNGEWLVDGPEGFDPDARRASAPPDLLHQIGLMGFATLPSGAPAPAPIRPSPLNAHFTPDSFQSTSPYYPPSTSSSSTYSYPLHPSSDSLSNDSPTAAHFERLKPGSRGEQPHQSQQQTALGQNHVNPGPGNRIPSYTSTTASQSPKNDVSPYSNNSMSYTGYQEGWNPSTQQQPFQQQHLTPTGQSASSIGAGAGAGLSIGLDDPSNPHLGHHREPNQAQGPQAAVSADEKTPTAEHAPQTLGHPGSNTDSLNSRGKEGGAKGGNEEGKEEFSYFGEFGGHDAVNVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C659</accession>
    <name>A0ABR3C659_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100058</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616538.1">
        <property type="nucleotide sequence ID" value="XM_066754637.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986916"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="329"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="460" mass="48440" checksum="76512950015B072C" modified="2025-10-08" version="1">MADSTASASNSGAESIAIAARRAFEASQLVDPSERDVALKAIRETLQAAKDEILAANKKDMETAEALAATGKLSSSLVSRLDLGRAGKFEAMLQGITDVAALPAPTGIVTFAKEIGPELELHRVTCPVGVLLVIFEARPEVVVNIAALAIKSGNAAILKGGKESINTATLLSSLISQALATTSIPSAFVQSVSTRSEISSLLAQDKYIDLVMPRGGNELVKSIQNNTRIPVMGHADGICAVYLDESAIQEKAVRIAVESKIDYMAACNAAETLLIHSSLLTTVWPAVASALMSNSVCLRCDPATLAALQDANIPEANKFVTASSPADYSTEFLGPTIAVKTVDSVQEAIQHINSHSSHHTDSIVTEDESSMSAWCRGLDSANCFVNASTRFADGTRYGLGTEVGISTGKTHARGPVGLDGLVIYKYIMRSKKQDGSVIADHEKGGKGYTHKDLVKGEPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6D1</accession>
    <name>A0ABR3C6D1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_100512</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616982.1">
        <property type="nucleotide sequence ID" value="XM_066755081.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987370"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0255705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="87" mass="9577" checksum="0E2D58A3AAB91A78" modified="2025-10-08" version="1">MAAVAPVNPKPFLQDLTGKVVYVRLKWGLEYRGYLVSTDGYMNLQLANTEEIENGKSNGALGEVLIRCNNVLYIREAKGKAGGMDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6J6</accession>
    <name>A0ABR3C6J6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MATE family multidrug resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617042.1">
        <property type="nucleotide sequence ID" value="XM_066755141.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987430"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="718"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="786" mass="85023" checksum="097C4D2AE1332326" modified="2025-10-08" version="1">MSNYPHSAAIASSLSTSPYALQSNLENLISRSRTHPHPQRVVGEHSPPYHNNHLRQPSPSHPHPEEGFDDDFGKSTTGQLPAAHHAPRVGTIEEASPEEPLIFQDDEDNLSTDRQPGERSSLLNHDWKRRVSRTSRRSYGAASAPVGAHEDSRRVSSVDALGAGNSRSRSKARTPPRRESVHGRKDKGEDVAQPPGVPAQYSSDEDSTSTRRGRLPGSRALSHTSSPYTSPTSPFRNKILRVADESSDEDEGGDLARGLLATSGTGVFAGSGRIGDAGLMELDPVEELDAEDLELPVEEDGKEARDRTSAIKAELPIILRSALPVFFTQAAEWSLVLASVVSIGHLGTTDLAASSLASMTASVSCFSILQGLATALDTLLPAAWTSSDPSRVGLWTQRMFIVMGFSMIPMYLLWWNISPILVVLGQDPEVSHRAGIYLKWLSIGIPGYGGNVLVKKYLQAQNLMHVPTYALFVVAPLNLFMNWLLVWGPDPIRLGFPGGAFATAMSYNLAFALSSIWAVLYGPREAFHPIRFKYAFSKLGTVTSLGLAGTIMLSSEWWAWEACALAASLLGPTTLAAQSVLLSTASTFFQVPASLGIASAVRVGNLLGAGRDWEAKWASRTCLLLSVTFALVNSSICIIFRTNWGYLFNNDPEVVALVASVMPYIALFQIADGIAATSGSVLRSLGLHTTGALINLTSYYIIGLPFGLWLTFTPTFSLGLIGLWLGLSVALGYASVLSAVLVWKANWIRAVERVRERLGLGVHGVVGTDGKWDEREQAIEEREELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C892</accession>
    <name>A0ABR3C892_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">General transcription factor 3C polypeptide 3 (Transcription factor C subunit 4)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617243.1">
        <property type="nucleotide sequence ID" value="XM_066755342.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987635"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="778"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="795"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1005" mass="114607" checksum="7C720131D50ED861" modified="2025-10-08" version="1">MSADFALDPALLDEDGTTVYTPLQDRGSSDSDDLYGESDDEYQDSQLDDVEEPDNDVVFGRLAGLASKTAPGKGKINNAEFQRELELADEEELPASRRSGKTLQKQPRRAHKPSHEVNYLLGQANGAYLVEDYDKAISSFLEVIRLDPYVPAAWVTLSSCYKELGDEERARQMRFLGAHVDDEGDLWRELAQEFKETGHLEQSVYCLRKALKCEPDQIDLLWDLGAIYRIQGQKTRGCNVYRAMLQIEPELANNLEFTSTFHPLLVSMNLRGLAAQTARRGFDYQIATYPSPSQRPRVPDAAPPMTYENIITLIDDLLALEEYEDALVVVKQGQRWLQGRAEQKGWDTMDDDREYDPPGTIREEVESEGFEMDVGMRHRLVLSRIKLDDIHEANIHIDFLLSLDVLTHYTYLQELGDALMTRDRWERALDCFAAVQECEELPDDPPLIYKIGVCQWKMGDLEEALEALQWVASEVPDNLEAKLRIANVLEDMGRKAEALDIVTEVIRTRGERGTLSSTIQMQPGVRISKRMLEEQLRSQMQNLWADVQDAERGTMEGEEGALERFVESAGLLIENYRMDRSNFTKNRGMVRVLKSKKYKKTDVDDQAAEMQDRLERTLGLEEIDDDNPYHVFRKTSFYGLSNEEWLTLVVKYCCVLMVRREEEVAMDILEHVVWSGLFHNRRCEIALRLTIIACAMRLKAYDKIVDSARKLALRSQFLPQPFLIMLAAISTGGSAARAVFTDTSLQNFINRDIRAYDEAVRNGDKGLHYLEGKGRWSANKGKTKGESKGGDGKKRNGKKAKGKKKVDIQIDPDLDEEEEAEDRVYGVEGEIGWGYKPVLPRKFSPYLNVILGQEMLASKAFKGAIFYLTRAYELDPWNPFICLLIAQAYLGRAMTRQSDNKNYQIAQGMVFLSQYRKLSPNSGPGMEEVEYNFGRAFHSIGVPHFAARHYEKVLDSVQQRMDESMFPEEVRKSSLAWEAAHNLMLLYSMAENMALVKEKSKWLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHR6</accession>
    <name>A0ABR3BHR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endoplasmic reticulum vesicle protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_106804</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610762.1">
        <property type="nucleotide sequence ID" value="XM_066761222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993657"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046460809" evidence="8">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0240254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="203" mass="23024" checksum="532A5AF531BF6E4A" modified="2025-10-08" version="1">MILRIPSLLFLFTLLTAVYAVKFDLTSDRNPKPKWFVTITNVPGEPDQQVDIQILDGSERGNVYLSKKDVRGEARLAVTTHESADVGVCLTNRYTGSGNPRVVRSVELDVDIGADAIDYNAIANQESLSILEVEMRKLEAVTKEIVEEMGYLQRREMRMRDTNESTNQRVKVFSVLIICGTIGLGVWQLVHLRSFFKRKYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI17</accession>
    <name>A0ABR3BI17_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610811.1">
        <property type="nucleotide sequence ID" value="XM_066760986.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993417"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="338" mass="36054" checksum="D13D84FA5BA316A4" modified="2025-10-08" version="1">MYSFMAGEERMVNVSCEYWKYRLNLAIQNVAVEMKSGEQKATAVCSVCIGLTGNITTAYDTGGVVSDADGPIIAKLHSNTTQPVLCAGSIAVQVANAVAQNVKSFEGQLDVHANHQDGAYGRKPVVLSPWGVQKNQSHGSSHYIPKNSISPANDLTLTSKPQKPRRSGINPQADYPQPVSIQSHSQPIRGHYPSVPNIPPSITTVLFPLPPILLPTPASPISPLLAAPPQAHYSPFPSPSSSHPSPHRHTPSSFPLTPRHILPHAPASSTSESIKGVSVRLDEIDRQKGSSSPSEENILKKIAWSSALMTLVIIAVVVGVVIVKNSKSDNSSKTEGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI29</accession>
    <name>A0ABR3BI29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP adenylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610847.1">
        <property type="nucleotide sequence ID" value="XM_066761022.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993453"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="89"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="228"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42065" checksum="94B66F5CA19B6B66" modified="2025-10-08" version="1">MAYPINHSNPTDLLSKVPEKFDEARSSGQLFFFPSEANDVISQGRRFNVRVCPSLQNKAKAKEDALAAVRAEKDGSPDKKRPRIAGEDKEEEPVNKQNELEPFKPPYVPELFVGSLEGLEGEEGMSILLNKYSLLPGHILLCPFSYQPQALPPTPPQLALAYNILLAASRHPTRPSKMLAFYNGGEGAGASQKWRHLQFVEAPGGKAPVEEWIQGVQFERLDKPVILPNVPYLHIVHPLPPSAQMPVPATPESTEQLIDFLAPALMRLLDMAFDAARRGGGHKDGGWNILMTLEHLHLIPRSLPSYSLPQPYPPLELNALGYAGMMLVRSSEQEAALMQAAESQGGLMSVLAKCGVPREFGEQVLEAEAAFHGQIEQEMSSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI46</accession>
    <name>A0ABR3BI46_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106614</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610862.1">
        <property type="nucleotide sequence ID" value="XM_066761037.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993469"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0240363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="106" mass="11538" checksum="89C96919F286937A" modified="2025-10-08" version="1">MSSRGGRGGARGGGNQGVERKKRESILNLAQFVDKSIRVKFMGGREATGILKGYDQLMNLVMDDVVEEYEDGRPTRSLGLVVLRGPNIVLVSPTDGSSEIENPFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIA0</accession>
    <name>A0ABR3BIA0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610932.1">
        <property type="nucleotide sequence ID" value="XM_066761107.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993540"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="94"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="451" mass="50219" checksum="5E4D0788A995B342" modified="2025-10-08" version="1">MYHHPFPTPATPGHKDPFQFAPPNLHPPPAMHLSQQSSRSQPQQSHTQQHSHPSHPPRHASDSHSASSSRHGSHAQSSHNHYSETDSEQDDDKIERDKLEIRREKNRVKQRNLRLRRANHIADLERDVANLKSDNTALQNALSVSQQHESNLQGWIHDLESVLFRNGLAGDVEGLRRIWSDRELKRGRPSIGGLPMNPAYPPPIQQQAPIDPLSTLARAASQLPTPSSNMYPNTQLPPNQPIVNPNGDRPTLPRPSSFSRPYENPYPTPDVAWSTQMHDYIHPEAALQAQEGGDLKRRRVEEWQPYGIAGRPPPQATAMTARRSDTILPPIQPLAGPSAEPTRPPSAPNAKEPQRFQEGEKGEKVSPRLIRISDLVSPSHAGETFWGGNSERLPKREENIPPKAIVPVNSIECQPPALRFDPGERSKMEVPPKGYTTGDGPLLTPLSETRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJR6</accession>
    <name>A0ABR3BJR6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611417.1">
        <property type="nucleotide sequence ID" value="XM_066760656.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993078"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="2">
        <location>
            <begin position="214"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="434" mass="47398" checksum="1A89D9F1CDC9792A" modified="2025-10-08" version="1">MSPYIHPSEASALEESSKSATTPILASIGTVLIDAFDSLPRPVVDDSPASSSRPASPVITEQAPQPQGHPQPLAIPPRRLRLSPPLASPATSGTSGPSTPQMTLDDIPVPNAEEIYEMLGGGALYALVGARFWLPPCQLRTLVDRAPVENDDCPKDVEEKLAKLGSEIWVWNRGEGTRMTRARIRYEGDVRYFQPVVKAPHRTVQELFTSPLLHAEYLHISPPYSPENVAVIISDLKALPKGSWRPKIVFEPTPPSCHPGQKDWLEHILPDIEVLSPNHEELFSFYSIPIMPTSSISLRPTVERLVSHILHDVSIGANGEGIVVVRCGRLGACVGTKKGGLRWCPAYWEGDDVKKVKDVTGAGNSFLGGYVAGLSLTNDPYEALLYATVSSSFVVEQFGLPLLMGCTDPLTSEEIWNADTPSRRLKELKRRLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK55</accession>
    <name>A0ABR3BK55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610959.1">
        <property type="nucleotide sequence ID" value="XM_066761134.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993567"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02118">
        <property type="entry name" value="EthD family reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="133" mass="15398" checksum="AC3D1201F387C60E" modified="2025-10-08" version="1">MPTAVISVVKESTTPTKQFWTWIVLTRRKEGVSREEFARHYHEIHPKLARRVPGLISYRQNLLCQTPGPESSIDSEFDACSEYTYVSEEEYTKAKGTKEWKALDRDSKEFMDMGHIVSFSVQSSVYWLPVPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKB2</accession>
    <name>A0ABR3BKB2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611230.1">
        <property type="nucleotide sequence ID" value="XM_066760469.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992875"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="27"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="118"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0241848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="30512" checksum="EE83A14A01D20D94" modified="2025-10-08" version="1">MPMPDEHIHPTATGLAKKVVDAHQDPQDLVFWSGWFCPFNQRIWIALEERKIPYQYHEVNPYKKEEAFLKLNPLGLVPTLQIKTPDGSKSLYESDVLAEFVEDLYPPSNQHPSIFPSDPYEKSWVRLNIQHVTKKIIPNYFKLQQAQTESDQDAARKELNSALHTYAKRVKGPYFAGRQWTAVDGALAPFVRRLYILEKHRNFDEKEVGEGWWEYRERLMARDSLKNTSSEDQYYEEILGRYLKNEAQSEVAKATRAGQSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKD6</accession>
    <name>A0ABR3BKD6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_106329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611034.1">
        <property type="nucleotide sequence ID" value="XM_066760762.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993184"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="658"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0240535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="679" mass="74550" checksum="4EEA327469FC2BDD" modified="2025-10-08" version="1">MAYPSRTTRPKRQSGASSLMSKLTFFAFVLVAVLCFLPAGSQVRAEEKDVDVGTVIGIDLGTTYSCVAVQRGGKVEIIANDQGNRITPSWVAFTDEERLIGDAAKNQASNNPENTVFDAKRLIGRYFDDPDVKRDRRHWPFKIVNKEGKPMIQVNHRGDLRDFTPEEVSAMVLTKMKETAEAYLGHKVTHAVVTVPAYFNDAQRSATKDAGTIAGLTVLRIVNEPTAAAIAYGLDRTGKHESQIIVYDLGGGTFDVSLLSIEDGVFEVLATAGDTHLGGEDFDNRVIDYLVKQYKKKTDVDVTKNNRAMGKLKREVEKAKRTLSSQMSTKIEIEAFEGGNDFSETLTRAKFEELNMDLFRKTMKPVEQVLKDAGVKKDEIDDVVLVGGSTRIPKIQQLLKEYFNGKEPSKGINPDEAVAYGAAVQGGILSGEAGSSDVLLIDVCPLTLGIETTGGVMTKLIPRNSVVPTKKSQIFSTAADNQPTVRIQVYEGERSMTKDNNLLGEFDLNNIPPAPRGVPQIEVTFEIDANGILRVSAVDKGTGKSESITITNDQRRLSPEEIERMVQEAEEFADEDAAIKRKIEAMNGLQNFIFSLKSQINDAEGLGGKLSEDDKDTILSAIKEKTEWLDEHPQADAEDYEEQLSELQATVAPITSNLYGGASGSSYDDEQMPFSHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL11</accession>
    <name>A0ABR3BL11_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611854.1">
        <property type="nucleotide sequence ID" value="XM_066759908.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992308"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="197" mass="21817" checksum="9F8C60D797D2D58F" modified="2025-10-08" version="1">MVNTATLFGAIEGVDPSYLPPSPSNLHPLVIAGRSEKDLQRTALTVFGNSDERRKPTFVGNAGNDAFYTLQILLALLFGSTLDELKAAYQEDSINPNFFKSSADPTRPDKVEEDTVEFVRDAPSRPPGLEGYIEVDREDMLPDDERIIYDDPDWVEEEDVIGVHYEDDEGNLLPLPHGPEQGGDEEGRTSILDPVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL51</accession>
    <name>A0ABR3BL51_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611888.1">
        <property type="nucleotide sequence ID" value="XM_066759942.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992342"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="440" mass="48988" checksum="23CD3479A540A405" modified="2025-10-08" version="1">MVHQESPSNSILLLHPRTLDPTHFVSRLISKDFPVISDTEPIPWTIDNKYYSAEVFFQLVPVSQNQDEDDVLTKYHDVGVVVYLFEGSIPKVLPPRLVKFMSEPRDVAIAVRALSNGLPEEIQDDKEGEEVINGTELFDEIGMEFVDEVNPLTDEDDERPMEPLEIIRQTLQIHLWPGMSRKPLHTSSQMPASTSSSNESSRAPSPEHAQFDVTFNPSVQDKKEDSVLGEGSSGEEGMGQFPNLQELVAQMYGADFAAVDDFDKFDGFSTGLESLSLAERGTYVSLDDMELSQDYDDYQNLEEWLEGDDESKGAEIEETNGRARNEVEDQLDQDSDQLDPGFESDPNKHESHPTGFQDDFTDFHTAPPPSSSTGSATLALDPTPLLLHLQSVRAELAGVEDEDERRLRAGREVSHMLKTLGLEVGDDDDLGLDDIGLDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL83</accession>
    <name>A0ABR3BL83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611916.1">
        <property type="nucleotide sequence ID" value="XM_066759970.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992370"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="378" mass="39610" checksum="B9107C51A6759F57" modified="2025-10-08" version="1">MAIATPSADTDTPPNTSITTPATQTLSQEDLVEAILDPIDSVVADFVDTSSLTSTDVKNDPILSSIAQKQVQGTIKNTPKAGFKAKPAPSSTHKENVAPRMTKTAALRLGLNWDDVKPKREVAEKAEEAKETPGYKRTGLNIKVASLAAPSVTPRPTRTSQLRTGVQVTPQSNKKGPQAMAAANKSREMQEKERRRATIALPTSLAAPSITPRQNKSSMLRMGVKSPQSVSSVSSTTQTMSIAGHGEELNGKREDGGLKPKLPRYSEIPPLKSLGTPSITPRLNKAALLRAPHSFHSSVPHSPSPSSSIPRGHSPSSSMSSNPRSSFAASGVTNRASTRSVTSKGGPASPTVGPRATRSSLLTAAQGAKVPKAVSSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL87</accession>
    <name>A0ABR3BL87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611761.1">
        <property type="nucleotide sequence ID" value="XM_066759815.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992214"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="910"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="758"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="879"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1014"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="797"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1014"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0243394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1072" mass="113980" checksum="7536F115176D7526" modified="2025-10-08" version="1">MSGPSQQLAPNMAASLAQLSPAKLSQLQQQIPDLLTDAEKLLPEDKRNEVFREKMLNKMVAQARQQQAQQQQQQQAVGMNMGQMGSGMMNLQNKPQMANQSAHQDQIRLQLAQQQQQQHVAAMLEKSRQAAAAQHQQNGAGPRQPTPKPGQQAMTPNPMTQAAMSASPNSHGIGSPQVNMRQSPSTASGATGRPMLNMQGIKTLVENFPKLLELKRMGKLKPEQERLFDQFISSPDGRNHLQQFQAHQARALVERGLANPVAMPPGTQPQPHSTQTPIMNNMNLPLTAQQQMAALQQQQQQQQQGFGQQQQLALAAQLSQQFPQGILPAGSNNQLTPQQMQQIQLQRLAAAQAQMANQSHVGLNIQQGRPPNPAMINQAAALARAAAAAQAAQGGAQAQSPHLQQGTPQASAPNLTQTPNQGQTSQNFGSPHPHPSLQNATRPIPGTRPPMTLQQMLHNIQPHLARVAPDKVESVKAVLVRLASMSDEEREVAFRQSTHWIPLWQRATAQPINNASQQLAAAQAQAQAAAAAQAQAQAHAVVQAQALAASHGQGGSPHINFANVNAARASSTPGQGGTPLPSNMNLPNLHIPAGKQRGSISAASANGQSPQVRPPALQGQSPGDIANAAGSGGPDPSLVQLMIEQGIPVHQAAQVLARQQQLAAASASLGMGLGGIPTFSQGSQAQAQAQAQAQAQAQAQAQAQAQLAGMGGGMQAIPGMGGVGGIGQQLGVAGQQQQQQQQQRNITPAMLIAQYSHEIPPRPPHLRPELILPDAPPPADRTGSLLARASATYTPVGSSSAQGQTQTGSTSGSAAVLGSGSQTQAQIQDEARDLRSTLFKPLNSMETGTKLVGRGTLGWSRVVRELVDDWPEGLREVVDEEAEDEEEGTGAMGDEGEHKGRVSGMPGQRKRKVQELAEEVDKALKIPKDSETLLLEIFDEHCDIVSESSCMLAKHRKASTVDRKDIQLSWELLYGRIIPGFSADRIRADQSRSSARHRQTNAGYAAKLRAVGDAKGAWRKEKREREKGKESDADGDKEHEREKGMVALGGTGDGIGVGPAIGPGIKVEEVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLM5</accession>
    <name>A0ABR3BLM5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="14">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I308_105659</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IND107</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="14"/>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612056.1">
        <property type="nucleotide sequence ID" value="XM_066760110.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992514"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07541">
        <property type="entry name" value="P-type_ATPase_APLT_Neo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="904"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="982"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1008"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1036"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1070"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="95"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="213"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="870"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL0243689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1106" mass="122760" checksum="6D301DE21E38376B" modified="2025-10-08" version="1">MSAYSHTPNYPLRTLSQRSNSATMPQLEPEETPLSSRTTLTSSWGRSKKKRVSDATEEETLLGANRDDTFEQEPGTEIQHSGRSKGRTIPLQPASSKSPYPANVVRNQKYSILSFLPLVFYEQFKFFFNFYFLVVALSQFIPALKIGYIVTYVAPLAFVLAVTMGREAFDDYSRYLRDRESNSTRYLVLVPQPPSPNPSSDREQTPSLPRPQTRATPASSIKVGDMVLLEKNQRVPADMVLLTTSEEEGTCFIRTDQLDGETDWKLKVAVGETHKMGEAFVGNAEGSLYADPPIKDIHTFYGVFTLRSTSPGEQTETSTPLSVENILWANTVLAAGSAVGLVVYTGKETRAVLNTSEAGTKMGTLEKEVNKMAKILCTVTFALSVFLVALNGFRGQWYIYVFRFLILFSSIIPISLRVNLDMGKTVYAHQIQVDREIPETIVRTSTLPEELGRVEYLLSDKTGTLTRNEMELKKLHMGTLVFGWDSMDEVSHLLSQALDETSGPHGRQGSLPGGNQRGKRDMTGRVRDTVMALATCHNVTPVINDDGTTTYQASSPDEVAIVQWTESVGLTLTSRDRTFMVVRTSAGRSLTFDILSIFPFTSESKRMGIIIKDRETGGITFVQKGADVVMSKIVQKNDWLEEETGNMAREGLRTLVLGRKKLSEETYAAFDKAYRAAQLLPSESRASSIASVISQHLENELELLALTGVEDKLQEDVKSTLELLRNAGLKIWMLTGDKIETATNIAVSSKLVARGQYIHQVAKLTTADQVRDMLDFLHTKLDCALVIDGESLQLALDRFRSEFIILATQLPIVVACRCSPTQKADVAKLIREFTKKTVCCIGDGGNDVSMIQAADVGVGIVGKEGKQASLAADFSINQFSYLTKLLLWHGRNSYKRSAKLSQFVIHRGLIIAVIQAVFSSIFFFAPIALYQGWLQVGYATLYTMAPVFSLVLDKDVNEDLALLYPELYKELTKGRSLSYKTFFTWLTISVYQGGIIMLLSLLLFESEFLHIVAISFTALVINELIMVALEVTTWHSYMVLSELGTALVYFGSMAILPAYFDLTFVLSSTFVYKVAVIVAVSSFPLYVIKAAHQRLNPAAYKKVAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLP7</accession>
    <name>A0ABR3BLP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Macrofage activating glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612083.1">
        <property type="nucleotide sequence ID" value="XM_066760137.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992542"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047364569" description="Macrofage activating glycoprotein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="43363" checksum="C62F8DA3FB29671E" modified="2025-10-08" version="1">MSSLHHLIPFLFLIAPAFSQYTATYSPYSLPDTSEQGQYGTNACGTSSSQDSKCQNVYVNGVDDFCLWGPPETTSNEGDGTSKIGNVEQIVVSYCLKDGYGTRLIPAGAITGAHFVKVQSDRVSYVQVTGVGDLTKLLIPAGDEGGELDPHSWTGLGNPQGGLVFTNAFSGSYEQTHEWTSFMSANEFCIRACQDGDNAAAYCQHIYDVLSCSFTIPGDMSPGFDSCLGAPTEEAPGVYSGSTFHQGDPTTPAPHPAGATSECQIYSSVGGGNAVIGNAAAVSATTTTWSSSSAEKTSSSSSSSITFQLNSTSATSSATSYTSPSNTAFLASVISTPSNASTEAISTSTITTSASSSSLTYLSSSSPLSPAHISASSSSSINAASTTALNNKQSNGYPKATTGMGVASVCMAGMFTLLFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM06</accession>
    <name>A0ABR3BM06_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611860.1">
        <property type="nucleotide sequence ID" value="XM_066759914.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992314"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="23"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="3">
        <location>
            <begin position="156"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0243493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="227" mass="24415" checksum="1769D9B72E0A997D" modified="2025-10-08" version="1">MATSRVEILNDGGLRQDARRPYELRSTSFQLSTHPSSDGSSTATQGLTTVVVSVFGPREPRNRSLASHDRAVVSVEVGVVPWAAGAGARRTRGDKRLQEIGAAIRQTFEPVIMTHLYPRSEIAIHVQVLSADGGILPTSINATTLALIDAGISLLDYVSSISIGLHLLQPLLDLSQPEESDLPSLVIASLPSSGKITLAQMETRLHVDRFEEMLTLGVEACKLREGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM20</accession>
    <name>A0ABR3BM20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611875.1">
        <property type="nucleotide sequence ID" value="XM_066759929.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992329"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31595" checksum="4D50AA7124ECEA32" modified="2025-10-08" version="1">MSSEAITTLSCDCSPGARNYTLEIGHPRCTVIKIIQDKLLRARLLSTDGVCEDREVFGDRTMEAIRRYEEVEWLVVSRVVAQSTWQALLGMEDVGPILHTSGTITPRPQPDNSTCWAACLASMLDLSVDCVIFHTPVSVLIEGALKNNSETHVLQNIPAIPGSKHGLVTFYPQGWLTGPLADLALAGPIMLNTLLEPDIYSRGYGSAGHCLLIVGVRGRREPDGKQLILRVWDPLPSRRGTLYSITYYDLMNRNPLTTFRITVRETSYRAWGGSGGEFLARYYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM57</accession>
    <name>A0ABR3BM57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612244.1">
        <property type="nucleotide sequence ID" value="XM_066759597.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991996"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046460952" description="TPR-like protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="529"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="711"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="888"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="982"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="784"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="982"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0243877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1125" mass="122511" checksum="EF2329E21B7683C2" modified="2025-10-08" version="1">MGTKGAHYSLALAHALAAGAWSSPSPAATPRAAPLSWPELVRKWGKHTGGNTSLIHHLRDISLLYLSTTNRPARGSPAPYLSPADLDGDDASDQRAWSSSQAWWSPVPADDTAEGIGGLQALIAGGKLSAADLVSAKLTLAYYLHATASHDAALRVYHSVDWAADSRLGVLDGDAAVVDRLRARCLQGLSYELSPTPDYARALQSHLAAVPLFQSLAAQPPFADYREACRFFSTALFRAAILSARQPGRAGQTLAILRTFHAYSAPWPPAFRPVQRQKMLILYLQTLSLSPLARRQWEEEALRALGNGQTLLEQTTTFPRAGSVNHPVILFCQHAMQLYTAHPRSPAMSNQVLDLLWWATTLTFQSQSILRFLIRILSDREEYTDAKRVFELYVGLVLKARQTAQPDAPQAVPPADTESSPDEAPVKDASSSQEIDDDSEFVSTLLAGAKLLTRMDQPDEAWRYASLAGDVVQVTKLPAQKKALQVNVEEVKGIVRMLMARNVNPHERAKYQSQSLNHLVFSTTTSPTPTSLYHLAHAYAQARQIPQAIDAIHKSLEMDEKNVESWHLLGVLLTSMRDWEAARKAVEAGWRVWEERDERDSQVDEIMEDGESLQGASGELISKDFAAPFSTAAAAAAAAAAPLVLPTGTFPPLPPLPESPPTSSQNLAQVIRLRMTLNMIIEKTQGCEEAMVRQQELFAFFSARCSRAGVAKQSPTVPAPAPAPAAASGEKKDVPDREEGLGESFVNIKVQDSIPATGQDGIPTLAPPIPPTPTPSSFDPALPVEEKQTIDENNHTHTLTPFRSISEKGRRRRRSFSASLRSKGGKSKDEMGGSTASHDGDGGGGVRRTASLRGTVLSGETEKKAVAEYGTVPKSAAPSIVPTAIHSHYRSSRVHRPSPPPPPPPAPTKSSSLPTTDTRSLEEKRILSDLWLASAATFRRWGKLEQCLVSVMEAEGLDPGNEDVWVQLGMYHVAHTAIATSSTSSKTGIAKGQEEGEGEGEYGEKQVWKPAEEAFSKSLLLKTDHPPALVSLAKLYLSTSTRQNLATSTPTDRAPKRYQGADLAESLLNPFTQSVGWDIPEAWYLLGHVARVQGREERARECWEFALGLEQGRGIRDWSCVKRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM59</accession>
    <name>A0ABR3BM59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphogluconolactonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612247.1">
        <property type="nucleotide sequence ID" value="XM_066759600.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991999"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF7">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="40366" checksum="966586A5EB97CAD9" modified="2025-10-08" version="1">MSLYKFLVTGYRPSLSIFSFEPTTAKIKLVSESSPAPQKATWVELADPSSVPSQGTERYLYSLSDANKGSAVSLKLVDDHIEITGQRVSHGGGVHIHVMKDGSGIVVSNFNGGSIIFFPITSSGALSETSESPLLTLPFVYESQTAPNATRQEASHAHHVVEGTNGTLYVSDLGNDRIWVVKREGESALAIKGYLQAPPGTGPRHSLISKDGKYLYCLTELTNEILVFPLTNPVEPIQPLPNFKCSIIPPSIPFAAHHYLNAAELIFNPIIPNVLYASNRLELSLPAQFATGQPGDAVAVVTLNDEGNKLVDVKFIRTGCDGIRGMRASPDGKYVAVAGRYGGGVEIWSVGDSGVDWRLAGKDENIDLVTDMAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM95</accession>
    <name>A0ABR3BM95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611385.1">
        <property type="nucleotide sequence ID" value="XM_066760624.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993032"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="142"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="709" mass="80059" checksum="2FA865A2221B9361" modified="2025-10-08" version="1">MVFNALPLHETLNLYISPTAYIFEPASSSAGHTGVDGALYADEKDVRESMVVDRQTGQISLSTASHIPFGKEKVITCYGIIGILSLATTDFLLIVTSRAPSCRLLSHPIYLANDYRLLPVSPLSTSSAILEHPVEKELISLVEHGLKSSKLWFSYGWDLTNSLQRQQEIDLKLSQTGEKWPAWKRADESFFWNRFLMDKMIDVTESGEADLSRFILPIMYGSIELRSSTLNSRDLLFLLISRRSRYRAGTRYFTRGINASGHVANFNETEQIVLYDPIPENGEAYRRGRVDGRERLSFVQTRGSVPLFWAEVNNLRYKPDLQIMDYTETPQALKAHLNSMIKAYGHTYLVNLVNQKGHEQPVKEAFERYLSLVASSDPSIQEKVHYLYFDFHHECKGLRFERISLLIEKLATALVDMGWYHSVNPDSSTYAPFQPNSAETQILAKQRGVVRTNCMDCLDRTNVAQAALARWVLNRQLRKVGILSVKEGVEDHEEFMIMFRNVWADHGDTVSRAYAGTGALKSDFTRTGKRSKEGLLEDGYKSVVRYIRNNFFDGDRQDGFDILTGAWVAKRGGIPPLTDTRPLLMRSVTLTLPRTSEMSIYSFLILWFFLAFFSGSYIWGNGTSYVSWPRLNPPLEILSYSGPGHRSPVRGRGMSFAAIVPLFDRRRRNGPGAGLLGATGGIGGRNDGRPAMYKMEESELGRRKGALID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BME2</accession>
    <name>A0ABR3BME2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_105231</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612335.1">
        <property type="nucleotide sequence ID" value="XM_066759688.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992087"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="12">
        <location>
            <begin position="434"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0243968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="763" mass="85235" checksum="90D92539F03FB75A" modified="2025-10-08" version="1">MVKSAVLGYPRIGVNRAMKKAIEAYWAGKISAEELQTTAKNVRKERWESIKNAGVDSIPSGEFTLYDHLLDHSFNFGVIPERYVSQKLDPLDTYFAMGRGRQDRSKGIDVVACEMGKFFDSNYHIVKVDHSPETEFKLNNNQALAEYKEAKELGITTRPVLFGPITYLSLVRKANSAPAEFQPLDLLDKLIPVYKELLSQLKEAGVEEVQLDEPILVMDKAESQGELFKKTYEALAPVAPKITITSAYGRVGKSIAFLKDLPVFALHLDLDREPKQLEEVVAAIKPTKLHLELGVVSGRNIWKNDLKASKALAEKAIAELGADRVSVSTSSSLLHTPISVKVENKLTAEQLSWLSFAEEKCEEVAALAQALNGTEGAIFEQNTKDIAARREFERTSDSAVRDRVAAITEEQLKRKSPFPTRREAQKKHLSLPKFPTTTIGSFPQTKEIRVARAKFGKGEITKEEYEKAMENEIKAVVDFQEKCGLDLLVHGEPERNDMVQYFGEQLNGFIFTQLGWVQSYGSRYVRPPIVVSDVSRPSPMTVKWSAYAQSLTEKPMKGMLTGPVTILNWSFPRADVSKEIQSKQLALALRDEVVDLANAGIKAIQVDEPAIREGLPLRKADWDNYLTWAVDSFRLSTSGVEDDIQVHSHFCYSDFGDIFPSIQRLDADVISIEASKADLKLLDVFKSYGYSNEIGPGVYDIHSPRVPSEQEIKDRIAAMVKVLPADLMVVNPDCGLKTRGWKETEESLANLVAAAKWARETYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMF2</accession>
    <name>A0ABR3BMF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BolA protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611995.1">
        <property type="nucleotide sequence ID" value="XM_066760049.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992450"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18042" checksum="673BF955DB3199FA" modified="2025-10-08" version="1">MRTPRPTLLARIALRPAHLSRTATFSPLSLSSNNKFVITRTMSAASASTSTSRGRSPTRVPGPVETTIQQKIIEAFNPVLLRVYNDSHKHAHHAAMRAQGGGSGETHFAIHLVSESFKGKTAIARHRMVNALLKPEFDEQGLHALSLRLKTPEEWEKEGGGEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMF3</accession>
    <name>A0ABR3BMF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_106251</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611445.1">
        <property type="nucleotide sequence ID" value="XM_066760684.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993106"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001138">
        <property type="entry name" value="PRK00143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="14">
        <location>
            <begin position="331"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="13">
        <location>
            <begin position="407"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0242063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="495" mass="55084" checksum="6D471D0CFD73E6DD" modified="2025-10-08" version="1">MSSLHIHYPPEQAQSAHILSICSLPEMWFTSLRPLSTLSKFHCSNARASKSLQSLLRAVNVNLKPLVRIRSTHTLAESELRNLLPTMSELGLREGDHVTVGMSGGVDSATTLRILREFPIHLDVIFMRNWDPLLSESPPESSSSPSSISFAYSSTTPMNGEPNLSPCQWERDWNDVLKVAMQVGIPKDSIRLVDLSKEYWSRVFEPAVGVWERGGTPNPDVDCNREIKFGALLDVLPKKDRHFLATGHYGRVAHLPHLGASKLLRATDQSKDQTYYLSQMTEPQLSRAILPLGGLLKTDVRRLAEHWGLPNAKKEESMGVCFIGERGKFGDFISQYTSPPEPGHLINLSGERLAEHKGLWYYTIGQRARVANQLKPMFVAKKGVGEKGTDILVVPGSDHPMLLCKGVHTSDFHWIHRTFPREQLDKEPEKVGIQVRHRMNPVDGRIVVGNDIKNVAVEFNQPIAGVSPGQVVAVWYDGWCLGSGVIKGTTCVGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BML3</accession>
    <name>A0ABR3BML3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612398.1">
        <property type="nucleotide sequence ID" value="XM_066759751.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992150"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013241">
        <property type="entry name" value="RNase_P_Pop3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0244031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="450" mass="49485" checksum="3946B80F64CB00F6" modified="2025-10-08" version="1">MAPPTYQIHNKGKGKALATIHGENNTIRAQSRMEKSAPIQASSDKSGLSKDVQKAVLASPLTIPWPDVPRHLQTTVVHLLRELIPSDVADYHVSRARCHIKEKRAKRAQKTKETKASSEQSDSSEKADQEQAGKADDEDAEMEDLESSAGQKQKQSSDIFESGLKRPERPEILSHLVLGINEVIKSIEHQIGSLKTRIMIMGDALNGDQPGKPDASNFLPTAPRSPSPSNSDDEATEGQSQSVLSPSAPVNFIIIPLLSINPQSLVSPILQYCATYNAHVYQHTQLAKILRTRLKKSQWTDVIGDEREEIAVVPLGAVEKDLADMVGLRRLACLALRKSHPNIEQARTLLPKSILRPPRFSVTLPIPTSTLKIHTCAIPSVSKSETSKGNQGPIPHVHYVPLHVKGIQTKMPVDNASKKAKRLQEVRLKRAEAKIKKKASKERAKKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMS5</accession>
    <name>A0ABR3BMS5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612088.1">
        <property type="nucleotide sequence ID" value="XM_066760142.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992547"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="89"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="378" mass="41925" checksum="CC06F92A56E283F1" modified="2025-10-08" version="1">MSPVQVTAERLATIPVGNCIQCLGSHPNHTLERKFEALQKGGWKHTEFSFAEYFQWVKQKETNVVPDVDPETYGDAEAEAGEEEVWETLYRYAPEAKALATKHGVKMWSLQCLGQVDSWPAGSRREIRGREKAVHWLELCSRLGLEFCQIGVNDHYDAVAPFEKTVKDLVWIADQAAARGVKVAYESWNFAPKNNQWEATWTVVQAANHPSLGLCIDTAQCALAPAYGFDPTSGRGFTPVAVQALLERLASLPRDKIFFVEISDVLAPQPALLCGSPFDQWHLDQGPGYRPGFTWCRCARVIPHIGRGTGKLVEGEQGLGAGRTADIVKAILSTGFNGPMFYECFEVAEQEKPDLSIPDELVQASVLSWERMSKAILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMY7</accession>
    <name>A0ABR3BMY7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612515.1">
        <property type="nucleotide sequence ID" value="XM_066759028.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991412"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
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    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
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    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="13"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0245431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="300" mass="33690" checksum="50FE395C43C89396" modified="2025-10-08" version="1">MPRFYENKYPEVDQLVMVQVQSIEDMGAYVKLLEYDNIEGMILLSELSRRRIRSVQKLIRVGRNEVVVVMRVDPDKGYIDLSKRRVSAEEVVKCEEQYEKGKAVDSIITQVAKKRGVTPESLYEKIAWPLHRQYGHAYEAFKLSISEPDAVFGSLGLDEETLADLRSGIARRLTPKPVKVRADIEVKCFSYAGIEAIKRALTAGEAISTPEVPIKVRLVAPPLYVMSTTSTDKNAAIELMEKAVDVIGETVRKDKGDITIKMKPKVVSETEDAELKALMEQFEAANMDQAGDDDSSEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN14</accession>
    <name>A0ABR3BN14_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Palmitoyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066760078.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992480"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
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        <location>
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            <begin position="13"/>
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    </feature>
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        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43511" checksum="6BB862981685692D" modified="2025-10-08" version="1">MAQAQTEGGPIQSTFSSNHAASSSMTENKPSKLPVSKSRRSLCSRPHNGPETPDSLVQRKFAVIIAIALSIWSFYVIVGRVCTPMIRNRSASDLGRSVGVGTLVGFVILWLFFSWSYIKMIATPPGYARDRINKSLPPDPANYPQPYSFNPNTMQPNQEEGPDPSTWAPTMNLATQAIADWQPDSSPEPFMGHAPPAGVKDKPKKGVKDWREIIAYGSGNALDGQIINFYIMILLIITEARSNSMDGQMIAMIVVAAIFGLFAVSMLLTHVQLILSGRTTVESFAARDQREREDALLQTEYGYFWHNMEKRKVRKKWKEEWGGSPVDGRWRYGTRMDRWKEEMGIGPLGWILPIGSPQGDGLYFKSNPKFGPHGEWLKKKDWPTELSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNB1</accession>
    <name>A0ABR3BNB1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612635.1">
        <property type="nucleotide sequence ID" value="XM_066759148.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991539"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="73" mass="8062" checksum="FE844B08F44BF368" modified="2025-10-08" version="1">MQAITAEQAHQSEAHGRDEQDVVMDDAERTQLMAEVNGVEDFVRIRKDFVDEGADATRTHVILAPTAISHIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNL5</accession>
    <name>A0ABR3BNL5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612743.1">
        <property type="nucleotide sequence ID" value="XM_066759256.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991649"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="207" mass="22608" checksum="EFB66E08D079EAD1" modified="2025-10-08" version="1">MGASSTPHPLPTVIITPSTPISDSSEDIALLPSTTQFYPSSSDKYSQSRPKRQRSHASRSYSMEYLLPPARLPSPKTGHRPLRSSLISLALLLMGLTLIASSVLCTGNGASAWIEMKYKGLQKLEGMGRDMGAKLGWNASLQPMATLRTLNMETSGDGEMHPSKDANRRDQSKELGNILPEGQNDASAVIKDSRSRRINRGDIWDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNR1</accession>
    <name>A0ABR3BNR1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612616.1">
        <property type="nucleotide sequence ID" value="XM_066759129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991520"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="439" mass="48368" checksum="74F442D047CBFA14" modified="2025-10-08" version="1">MAANHGVFFHPPQPLSSPTTPTFTPSRKRRAASPTLDSDPLSPWHQSGPPPTSFTDTPHREKRRRPNLANGFSSLSISPTATHSPAVPDQPRADDDDEGIGPSVYPRNDDVKVEVLPDNTNRLSDRQHPFHRTHAPQWDPYHARLSSSSSSASPTTSTDETYDSDAIFTRNHPLIKRYDGTAQQADEIVQPDGSSMFTGPDLGVEDVTGILPPLRARRPREEDVEVMEHAGKKRRVSEMDIDMSTMDGNTEDASIEEKDKLRGRKTVWYEPEKDRIVITSLSDSDSRSSRSPSPEADSGYLSQPGEQGFTISPSLLTHLMNAQRDNDLKGPLRDLLKNNQRSLTLYRPLGIPADRWKESIVKTWEDAQNYDDSGRFEEIDDAEDFGNNMPSTGNADIAMGMEGTVPAWQGDAWNMGEAGMGGSGAVSGDGDVDMAMDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPA4</accession>
    <name>A0ABR3BPA4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612982.1">
        <property type="nucleotide sequence ID" value="XM_066758534.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990910"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="28"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="518" mass="58225" checksum="0950E6F5686D68F2" modified="2025-10-08" version="1">MPDWHDIPNASDRLKWYQNKGALKLNFFLSVIFVGMILNGYDGSLISGLQASDAWQEDLNYPRGVRLGMLNAVGNIAGFVVGPVIAYIDEHWGRRWGIRFYGYTILIGSIIGCIAGVSNVNGYALFCTGRAIIGLGLASFLMTSLIVVQEIAHPRSRETVAASWNSYYILGLVIAAWVVFGCTGYMTSSWSWRIPYIIQVPMALYILIAVQFVPETPRFLLSQGRDEEAFAFLVEYHGNGDREDPLVLFEFEEMKEAIEQEKVAKAEKWTTIVKNPSNRHRLGLAVLMIFLTNLSGSSIIYYYYTTVFDLVGITESSVQTGINAGLTIFTWFCQIGAVYTGRFVGRRKIILWVWPTLLLGLIGLCVSSGVFANSNDQGNTKAGIATVVMVWIYLGCFNFSNPILYSYPAEVQTFSMRSKGLLIWNTVSQLEGAYVTWVDAIALDSIGYKYYAVYMPLVIIQWFLVYFYMVETKGYTLEEIALAFDSKENLTTVNILPAVEQEQDVEDVETKRRSTDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPB8</accession>
    <name>A0ABR3BPB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104893</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612841.1">
        <property type="nucleotide sequence ID" value="XM_066759354.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991749"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14212">
        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="375"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="708"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="789"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="992"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1118"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="849"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1015"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1134"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1147"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0245757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1158" mass="126742" checksum="DCE63DFDE3257848" modified="2025-10-08" version="1">MTPADSFPDDPLQLPLFNSNSPYAHHQPHSQLQMPSANSYLGRSASLGRKKDPFAYRSDDVESGFGNMDIIDPGQQQQQPQQPGWGGYGYAQAGYRDPIVSPRSSGYQNMENQPAMNPPPVPSHNLSRPPPTVPEHPSPTTIAANNPYIPARSSDPGPSVTDRSNSYSNSTRNSAADPYHPGATGASQWTEYRRPSIKSRMPSSSSYASKGSDGLSPFISPGTLDTNVGMGSPGHSPLLNPNDIPHAGWSSPSIPHIQPPSPRNYAPQSTATRPQASPVGGRPPPASSRPLSIAAPQTQGQTLYPASQPTTPQSRYDPNMPPPRTAPSRSDTGSTNDRRSSSAVSNREEEFRDIRGLADLRAVVNALPNGRRADPDAPGKYLSGTFGQVVKCQNMRTHDLVAVKVVKNKPAYLQQSKMEVAILELLNTQHDPHDRHHILRMLDSFTHKHHLCLVFECLSSNLYELIKQNQFKGLSTQLVKVFTQQLLDCLSVLKDARLIHCDLKPENILLKSLQSPQIKVIDFGSACHEMQTVYTYIQSRFYRSPEVLLGLPYSTSIDMWSLGCIVVELFLGLPLFPGTSEYNQISRIVDMLGNPPSHLLEVGKQTHEFFNITPDAYGRNTYKLKPMHQYSMEHRTDEQPSKQYFKQTKLKDVIMEYPYAKRNVKQNDIDKEMATRRSFVDFAEGLLNMDPIKRWSPQQALKHPFITGEKWTGPWQPDTTTTPKKAVVSSSEPSASNSNAPANSISTPSKKYGGLVQSPPSSRSQRIYSDAAAYNQQLAQHQTYTAQVQAQQNAQRAGPFSPGYNMAQAQAQGHAQAAGGSGGGSGYGHHRVVSQQIPSAASRHHHAQQRQPSGQWNQQMAPPSSAGYQQRGPSLNNSASHASLRQPPSNVPIISNPPPNSYYPASRHRANTINQMDAIPPALARLVHFGAQDPNGSRNSLTPVLNRDDAIREWERRQQGGHSKQSSLHNASYPQLEYLQEQAELAAMQGQNWMVPGPYPPHHGHGHSHRSSFGEQSQSHGHRTNPSGQYQMQPHIGISPPSTNDYRPRPTSEYDPPSSNASARGYGLPTYPPLAATTSHPPGGSASGAVGVGQGVFDAFDGRDGGMGMLYTPLQPNQAYGYQGHAGQHGQGHGSRASYSGPYSSSNPFANQPNSPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPF3</accession>
    <name>A0ABR3BPF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613027.1">
        <property type="nucleotide sequence ID" value="XM_066758579.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990956"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38844" checksum="F05537A385DA0D1F" modified="2025-10-08" version="1">MPLAEIQHLILDELANLDMLTYMCISKYHFRRMASRIYEVFDIPWQTRGIKRTLAGTNPLSQTKLEAFRNVKVLRLGSPFLPLQIQYPYIHQEYGISRIFDPSEMLGMFWFLLKQSARIPQGILFPQLKEIHINTRLCTINFWNTAIVRGGYNRPDIVDQSERLWYMIFAAIPASCRVIFHCILRCQWVDFDGAFSPYIAANRLLGPLGKCPEFSIHFHAMNDTPLPIRWSRPPMAPHHVVKWNVYTPYHPDYDGIVTREAESAFDHAADAPEIGPVGDAHERMLNFFWPETMLMPRQIPFSYTTFKATYKVARVLHVADVNRHNQYPSTGDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPQ4</accession>
    <name>A0ABR3BPQ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611958.1">
        <property type="nucleotide sequence ID" value="XM_066760012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992413"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="115" mass="13305" checksum="8F89E8F8478F761F" modified="2025-10-08" version="1">MTDVYGPYIPEPEDGYIDNVRYVGEGIELLNTHEDFNQVVVCIQRFFAEETSPPQRPYVTLYPLEEGQKCMQISDPDGCGFPYLYTLLVMNCLPQPCMMYEEDRIKVWRGLGQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ05</accession>
    <name>A0ABR3BQ05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612684.1">
        <property type="nucleotide sequence ID" value="XM_066759197.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991590"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="711"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0245600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="735" mass="77755" checksum="A1DECE6154E3E53E" modified="2025-10-08" version="1">MVSTRSLPPSAISPKRLRSPRSPHSPKSPRTKHTDAFAPLSEVLTDSPSDVAMGLNADAGVSVSPAEPYLLTRVLSGGSNASTLASNAGSPGMKSVPLSPSSQGTRTPKAGRAHQLASDMDGLNVRSPVSNDGSVPPPSGTKSIKDTKNGRGSDNVGQGPGSGDTNGDHTKQRSYTSSTDSSNSQHPVPSPHLGASYGPEGFPVFRHSPEASPMAYSPYLAGAGASYFGGNGNFDPELAARQAALLAKADEAVRQLNNTATVFQGPMPSGLAYPEMFGQVPRNAANFVTPHQNPTVTRQSSTSSSITDAASTSSEESDWCIPTVEWVPANQWQHPTYLNSPGIMFNRQEKDRVPSSSRMPPPSGTRPPSSSQHPSMNPSEHAPLQHQSSLPFGASAATPPLNTSSHPSWITAPASESPDEDDDGQTVGHARDRSPSTSSQSAQSGLDLLWQAAHGIKQQQPNMPRDVSFDHKGKRKAGAEAVDKWRASGIPTGPPPPVGASQDEGKAGGGTPPTTGPPRKRRRSEVQMEEMEMDNAAATNEEVEEDEEAIAEDPTSDYRSPSTSEGPVSDHDSEYGSGARRGRPVARGRGRAKASTSARGRGVTANTALSSAPGGVTKQGTIKKVRKVGDSPNGTAKGGRKPAAVPPGGVQCDYVNPLPPYNRCTDVFTRKYDLPRHMARHARREGELVMEGKLQEDKAVLWKTIKDKPKVVCDTCGESFTRMDALKRHQAKQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ26</accession>
    <name>A0ABR3BQ26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612078.1">
        <property type="nucleotide sequence ID" value="XM_066760132.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992537"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="752"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1259"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1475" mass="158386" checksum="4604ADE5FF8BCA31" modified="2025-10-08" version="1">MPPPENPPIDPFPPLRPTFSPVESRSTSYAAVVRRNTNINTNTDPSVSTIPDINISGTSSAGRDTEERYPGESSSGRERVHPWRESVHPWRERTMDDNGNENQADTSRRTGNAGDSADDNPNSNANISATSSSSTNQNTSTNTDSQTNINPAAPFTLREMLRNIQAPSAAPATSSPAWASASVSAQAPASRSTSRIGVNGLPYVRYYDFSHPTRDGNGRLNIRENDDRPTVSGLLSRIIDSPNSASASAATQNQNQNQNQNQNQNQNQNQSQNQQNQTGAQTQTYDQSAYSSPPFNRPSAARRGPPIITDGNDRYTSGSTPIAQGQGQGQGQGQQRNYFGPIYPVPLPNNTNNANNANNANNANNANNANNTINTNNRGGNSGGNGTGAGEGDDNDIIVSFLPSPPRLFDSDGDSLHSLTDEEDDDGNRVYGDGGDGRELWDEVEWMREVLDADHASGTGTGTGNGAGAGVGAGAGTRNERPFPFRRPGLGSAQADGATGQGADLHRGGFNRRRDYLDFLDHVINLPNNSSIPSTLHTHSHPRVQNLINDDLSNPDRNTNGGPSAEGQAHGVSRPLEYALNISRSSSRAESRAAGLSPTNLGPAQVGVRPPVLVSSASASSSRRSRGRRARSAGPDLDMDEHGEGAEGLPGEDSPARKRSRTSASSSSSASSSLNTNTNSTLSTSSSDASSPTHAQSRQRSGPAKHFRPPYLSLSSLPVDTALPLDLGFPQPPSSAHLTLSLHIHRPSPTLMPVPLATNTETETGNKAKTGAGKKSEDVLPRRSVARRDPGYPVIRPCITFSHPRPTRTDSDATSLMTTLPVPRGVGIFYWEAEVLAKGEEGFISVGWIAGLPTPVIPPDQMDSTNADATANANANANASESGSGSGSGSIILNANTIPNTGGAGGHAGVPMRNMRRLVGWSKGSWGWHGDDGRLFAGQGMGERFSETWGEGDVVGLGLDQTTSTLFFTKNGVLVGSKTFPTLPSCGPPPPPSSSPMPFVSQRQPVITKSTDTLLYPAVGLRSQGESVAVNLCGPFRYDIEAHVRGVKERMSKEVEEVELKKVASVVDLVDDRDVAVADAEQARETEGKCEDRREGEMKEPIGSSHVGTPIHRISSATTPMSTSAPEPLSSNSEKRPPCAPLDPLCLTTTAFVLDYLNHHGHTKAEGMMRRAIRGRNWIGAPASSSSSSSSPTATDSRILNLATSDDIRMTKPNQTLQDFPTISSALLYLSNLIRKPFEERVPWTLWKELALLDNASAHSREDMEEREKGKGKGKERALESGIRDLRHKADETDGMEREEMELEGSLLVYDFLHAAIFSAADQDSIEVDGEEGMKEEQQGADADARTIAIGRKIQGHLQRSCTPLPASTLPAVLKSRRQEDDWAIYAKEAFGAIVDPQRYSESERWAHWRDRLAGRLEVFLRRRRNLPQISRLETAIIQTDAVVHALAERRPNSGAAFVDVKGALRLSEAKEKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQS8</accession>
    <name>A0ABR3BQS8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613168.1">
        <property type="nucleotide sequence ID" value="XM_066758720.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991098"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="58"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="347" mass="38590" checksum="0E642F82A2E6C1EA" modified="2025-10-08" version="1">MASGSLSNNKGISATAKHTDAEGYEMPWVEKYRPVLLDDIVGNSDTVERLKVIAEDGNLPHIIISGMPGIGKTTSIHCLAHALLGEAYKEGVLELNASDERGIDVVRNKIKSFAQRKVTLPPGRHKIIILDEADSMTAGAQQALRRTMEIYSNTTRFALACNMSNKIIEPIQSRCAILRYSKLNDAEVLKRLKEICDMESVKCNDEGLAALIFTAEGDMRQAINNLQSTWSGFGFVSQDNVFKICDQPHPIVIRQMIKDCQYGKIDEALARVNALWDQGYSAVDIVVTVFRVVKGMEELPEYLKLEFIREIGWTHMRILEGVGTLVQLGAMIARLNKFALPPNTLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQT3</accession>
    <name>A0ABR3BQT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase III subunit RPC6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613526.1">
        <property type="nucleotide sequence ID" value="XM_066758124.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990493"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="532"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="62073" checksum="FB8EB5CCD88399E0" modified="2025-10-08" version="1">MSSMSTADQQVWKKVLAAKNKNMSLTQIEASFPTMSKKAVMSSVTTLLKLRLLSQVKGKGDDKAMVYHAHTPEEAKQKATLTQEQSIILSIIRSAGNRGIASAQITRTIGTDTMPISMLRKVLKTLESEGHIKQFKPVNAPTSVYYILAHLKLPEEISGGVWFDDNKEYDQGLVETICAVLLNRVRTATYVDNKKRSEEAKSLVPNALNTSTKYHSLLTPMALRTYVNKLGVTSATLSVKNVMECMRALELDGLVEVIKPVGGVHLQEDSDDESTARSSKRRKVESDSEDEERDKEREKAKMKAKEKAKMKKRREKEKERERKEKERERKRKEKEKERERRRKEKEKERKRKEKERGKKKKKAYGSDNEDSDDALLSINDDGKKKRSRSLSISSVSSISSSSSSSESDSDTDSDSSISSVASSQLDTSTIPFRPSAAATVPPSTPAQIIPGGLSGGLTDLTDTAIIYRATSRISIPLGQTQAPCGKCPVFHFCEEDGPVNPTGCEYYGEWLGDSVGGWEKEALGKMRLGWADNEDDKGKEKTNEAELNGNGDVVMEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRD5</accession>
    <name>A0ABR3BRD5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613179.1">
        <property type="nucleotide sequence ID" value="XM_066758731.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991109"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="83" mass="9430" checksum="44533F29E8DE35DC" modified="2025-10-08" version="1">MPLCCSYSCTFKTANAQHHYQDDEELCLVSRVDVVFIEFKTIVLGENIDEIPVRIIVGISRQPQPLATLSRHTQVVWIAIILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRT1</accession>
    <name>A0ABR3BRT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613853.1">
        <property type="nucleotide sequence ID" value="XM_066758451.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990826"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0247892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="571" mass="62018" checksum="729529E5F29741D9" modified="2025-10-08" version="1">MGSSMPPPHVRAWYSYAFAAEVFSACALAIFLPVTLEQMAREVGYYAPDLTERCAINDSAPDVVERVCKARILGVWTDTASFSMYVKSIAVACQAICIISIGPLADSAYWRKRLLLTFAYSGSLSGILFLLLPSSPYAWTPIVAALLNIVGNATYATSIVCSNAFLPGLAKEDVDVQKAWERAASEDSQEALGDVNEDDEEESRRMVSTEDEATHLLPDRLIPAVRAISTQDLALSDPLTKSVEPFSAKKHYESLLSLTTSRLSSTGTAIGFFSGVSVLTLLLVPVMALGGSTFSMRLAIGLSGVWWALFSVPTWMGLPGGAPGQESDFNASQVKEAWLKIGRMIAPKQMRQLPNLYVFLLAWIFLSDGFHTTTYAAILYASSVLSMSAPKIVVIGILVQLSAVISSILIPRIQRHLSTSSSKPVTNYKVLFAGVVAAALIPVYTSAGLVLPFGGLRSEGEMYFLAVWFGLVFGPFLSYSRAVYAELIPPGHESTFFSLFSFTDKSASFIGPAIVGLISDLTGNIRYGFLFLLAMLVVPIPVLGRVKVEQGRREAVEWTERLRKEMSSGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRX4</accession>
    <name>A0ABR3BRX4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613035.1">
        <property type="nucleotide sequence ID" value="XM_066758587.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990964"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="446"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="944"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="957"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1124" mass="125711" checksum="0213C8CC6A423E16" modified="2025-10-08" version="1">MSNPPTPTLASLITSHIPSPSSLSTPTFGAGSQVGYGGETPHMLQRAIMQGEDVPESPVIDRDAGTDSPDVHGDHGAFAGPSKSFRKAPTPLFLNDPSSQTILPLLEEEEVAQELCENVDENRELRTTLILRHALQWGIERGDVELVNWLVSLNGRWQIILDREIQDLEDEEGWGIVCMAIHHSCGRQDREEIVRAAVSRWGVSAGPRDGRDRRGWTPLHLAVLVSTPPLISFLLSHGASPHLLTNRGLTPLDLVADIPGREAITLFLEHAISVPHPSSPLTSTIFIPKLPPARQKMLIKRRRRARGHLEKMEEQERKEKIRIERAKWIAEKLRVVEVPPELVFGKDENPGRNKEDMGGSGLEEDDVNNEEDDGAEEEDELNPASIANMLVFSLVNLPEIFDILISNYEPVSQPLSKRTLPANVLCYYARFAYHMCEETWLETLIEGAIERIEEGVYENMENLAYLAFWAYNSCVLLHHLRADEALQEACDELGLLSILEELINTIHVFVIRIAERRIDTVLDAAILDYETLDDFNDIRFEGEWSLFRSFVSKKKRDTPKVNNNVFAGVNGSPGGMNDAPASPIGSKGLKAPNRPQSMSDLKTVSNGRSATHEPSANLDNNSGPAFITEILSGAHVVLQLYEVNPALIVQTFSQIYFWIACELFNRILTRRKYLCRSKALQIRVNLTFLDDWVRVSGLPAQTSARHFAPLSQLLQWLQCLSQITEFDTLIGTMQSMKAINPLQMRRAVREYRYEVNEGRMSDECAQYLAQLQKDWEKRRVQLSMQEAEHRKSASEWSEGTYGSGMSRSSGYKESAMLIDALFDGSTTLADFVPHSAPESLGELLDSRYMLPFLLPEDNIYLIATPPTDAAYASLHIPSSSPFVTDTPTKRPLSHASYSSSRAMGYKIPNIGKLRDLPPDFFKWMKEKETELKLGREALRVEKRAAPALSHPLGTSQKAKDTTPVRPPPEDKANLTPTHTPTGNRRKSGALAPPLPVEGAELSTTLSILYPSTPTKLGAGLPSPGLRSSASMNELREKKLAERPFEDIQEESSSHIKSESYEMRMRTEMLRENSSESVSSSGSKLSNGSAASGGNRTKRWWRMSKVFCFLNVESRQDGQLMWLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSJ2</accession>
    <name>A0ABR3BSJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613921.1">
        <property type="nucleotide sequence ID" value="XM_066757537.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989891"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0249734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="431" mass="47642" checksum="C4FA27C2C96198A2" modified="2025-10-08" version="1">MATSLQTSIENINLTVTSYMIFQAITPTFWGAISDAYGRRLVLISTLVVFFSACIGLALIKHYYQLVILRCLQSTGSASTIAIGAGIIGDVADRKERGSYMGFFQTGLLLPLAIGPVLGGIFAQTLGWRAIFWFFVIYAGIFLVILTIFLPETLRRIVGNGAIYPPARSRAPLEGFIASRDRKQPPITSTTPIRPDWIAPLRILFVPDVFLTLFFLSLHYATWQMAITAQSSLFKSTYNLSEIEIGLTFIANGFGCMLGTLSIGRFLDYDYQHFKKKFSGPASDFPIEQARLRTVWFWSPFQCAAVLWFGWTLDQKVHMASPIVASFVLAWAAMSIQAVISTFIVDIFPKSSASATAALNLARCLMGAGATASVEPSINTLGVGFTFTLWACLMALSLTFVGVQMRFGSTWRKRREKRLEEKGEGARPRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSS7</accession>
    <name>A0ABR3BSS7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STEEP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STEEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614195.1">
        <property type="nucleotide sequence ID" value="XM_066757811.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990167"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029704">
        <property type="entry name" value="STEEP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057965">
        <property type="entry name" value="STEEP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355:SF1">
        <property type="entry name" value="STING ER EXIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355">
        <property type="entry name" value="UPF0428 PROTEIN CXORF56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25809">
        <property type="entry name" value="STEEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STEEP1" evidence="2">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="160" mass="17461" checksum="445B55D89964AE44" modified="2025-10-08" version="1">MPKIVSRAVVSSSEQAALTQSARAVLRSYYCLCGDFVLVLQGKLDRLPRRRTDGAYIIRSKPGSDPEKQPARKFKLNAQPAQRCLLKRKGTADLEIRQPFCCARCKTPVAYQTAAPPAGEGPFLYIIKGAVTELQGRVPADAFEGEELLPPQDEAAGSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT39</accession>
    <name>A0ABR3BT39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613455.1">
        <property type="nucleotide sequence ID" value="XM_066758053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990415"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="430" mass="48469" checksum="D857DC3390A10787" modified="2025-10-08" version="1">MSTSSNSLHVAGGSPQFIDGGFIELVAVIGTGAYGVVYLAVDSRYPQPVYRAIKCMRRSGLDERQKHFQRREMGLHRLASGHPSIITMDRIFEEGDYIYVVMDYGDEGDLFSMITDKKRYVGDNELIRNVFLQLLDGVSWMHSLGISHRDIKPENIVCSQDGTRVRICDFGLATSEERSSEFGCGSTFYIAPECLGDWFPENKTYPTRSGDIWSLGVILVNLVCGRNPWRIASPSDESFNSYLADPHFLRKILPVSDECLYILTQIFTVHPEERITLPALRQLISEVESFSMTVDELRHAHISAQQKIAAAQPPVLLSLPREDDGWSEQEELFAYDDELETPSLRSDSDSPRYPLCLSPTTSSNGESLPPTPNLIPDECIAFAHQPQSPQFWEYVPKVTFEYDHNQRSTDVHIKGSCPFTYNSAPTTYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTH8</accession>
    <name>A0ABR3BTH8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614449.1">
        <property type="nucleotide sequence ID" value="XM_066756980.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989292"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="439" mass="49220" checksum="2B982AAEC32A98F6" modified="2025-10-08" version="1">MTALIVLFLPTERTRRLLGDEAWDNLAKFGIARSLKDQAFSNVPARGCSMCEVDPVLCEEIGRDNLERSLAFSGTNRRLRRVLAKFRRGETINVGAIGGSGDSGREEGKHGYINGGQGALGTDYFSYCWEEHVPADLDLIFLEQAINDELLLRNINSYELLVRSLLDLPTSPAIVNLDVFALKFNSITMGGDLHLGIAQFYYLPVLSLRNAILNDMLKNNSLVSEYFFVHADGEVDLRHISRKGHNITGRIGAAYMDSQICEMDKYEQSIPGADSMSIDELYPVEPIPRMQVNMKYDENLVLPTIKPQCFSANSDKHPLTPVENNGWREWNWKEKHYLVADVPGSRVSFKLSTSLGKIELQYLRSYQYHQGSAKCWIDDEVGKAIKSDGYWKEPFNIGRAATIGEGLEPGEHTLTCELLNEAADPEGGLEFRLISIMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTM1</accession>
    <name>A0ABR3BTM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-binding cassette (ABC) transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102475</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614489.1">
        <property type="nucleotide sequence ID" value="XM_066757020.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989332"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="141"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="459"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="705"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="715"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="78668" checksum="A4D7173BF4A87FA1" modified="2025-10-08" version="1">MLGTIVGFHVQLRQQLFASAVRLRPMASGSLYSDVLLSQSRLLLQPRPLLCRPLTNRPSQASIQQTRSDESVHSAQPELAEIDIINPEQPAKRQSLISRLTSKLSLQSVKGTSSENGGSETGASSVRKLISLAKPESRPLAVAVGLLLISSSVSMLVPLTIGKLIDFFSTNSSTFLGFSFPVAAGLLAVTFCVGAAANAGRAIIMRISGQRIIARVRNQAYHSTLRQEPEFADRSAGDIVSRLSVDANILGDSVTSNLSDGLRALISATVGVAAMFWISAKLTLVMLCVVPPVSLGAVFYGRYLRKLSNLTQEAVGDMSKVAEEKLNAFKTVAAYNSQSLEANLFSRKVDQVFQLAKKEAYMTGIFWGASGLTGNLAMLCLLGYGGHLVATQEITVGDLTSLLMYSAYVGGSVSGMTGFFTGLMRGVGAGGRVFWLLDRQSHIPLEAGIKLSASRNGPIVFKNVRFRYPSRKEVEVLKGINMAIEPGTSVALVGSSGSGKSSIQALLSRFYDPGEGQITFDGTDIREFTPESWRSRIGVVFQDPILFAGTVHDNIAYGSPDITREDVEEAAKAANCDFIWDLPDGFDTMIGKASLSGGQRQRISIARALVRNPSILLLDEATSALDSTSENAVNAAIDDIIHKRNITVVLAAHRLSSIAMAERVVVLENGVVSEAGRYDVLSRREGSRFRTLMAAQLLVEKNSGIEDGVPEEEREGNKMELEEAGVIEKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTW0</accession>
    <name>A0ABR3BTW0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plectin/eS10 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613725.1">
        <property type="nucleotide sequence ID" value="XM_066758323.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990698"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="147" mass="17022" checksum="5BF2EF2E3FE0E006" modified="2025-10-08" version="1">MIISKQNRRAIYEYLFKEGVLVAPKDFNRPAHPDLPTVRNLEVIKAMQSLNSKGYVKTQFSWQWYYYTLTEEGLAYLREFLHLPSEIVPQTHMKPVARQTGRPSGQREGGYRAPRGDREYRRRDDGEKEGGEYRPRFGGVARGAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTW9</accession>
    <name>A0ABR3BTW9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613740.1">
        <property type="nucleotide sequence ID" value="XM_066758338.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990713"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="505"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="708"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="938"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1087"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="942"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1130" mass="127320" checksum="18098DE7411702C5" modified="2025-10-08" version="1">MSSTADYVAKYPRRAALLHTVEKYWLDDARRPPGSLDSSLKKHTTLINKLKSSLLIGPTEALIKDIDGLTLTKYLDEIVAAVVEGAAKKGDPEVAVDVIVHLHSRLTPDFLPQLLQPLLTLLSANAAVTGPIGKDGDKDKEKEDKERLSKQRPVLRIVAELAMVGAWAEGVVKGAAEISKALKGLMTGDPQYSNLPLITTFLKYFGRAYLGNNPISSSQGPTDGAVKDEVEMLPDGVTELVPPEVQKQMWQLFVNYFNTASKTLVKGQLKLLEQDKRNHEAYIKSGEIFEDRQQAYEKMTRAVERLTTGVQTLADLLNLTPPTLPTAASLSKSGLQIVESSSSFTVREDGPIAGGIWDDEEEQKFYEDLIDLKEVVPASLLGIKEKSKEDDQEGGGESQDKSEEEGGNQQKAEEEALRKQLEQMELADSQAQPESEPEPEPQSQLQTLDRPASSSSLDSVAVAHEEEVQAHVEDEQAATVAMTTTTTTTAAIEEDGLQSGPAARLFALFAALPESNNREVVDKLAVEFAFLNSKAARKRLIKFLGEVPKQRTDLLPHYARLIATLNPYMPDVGAGILEILDEELRYLQRKKLVRELDSTRLKSVRFYGELAKFKVAKPFNILHVLKVFLDDFKFNIENISNLLETCGRFLLRYEGTAEVAKRMVELMRKKQANMHLDQRHQLMLENAFYMCNPPERVLREVVQLTPMQNFIRHLLDEVLMKRTRDKVLKLLRKLHWEDPEVYDFILSAFANVWEVKFGNIPQLADLVFDLQRWHPEFGIAVVDQVLENIRIDLEENIFKFNQRRIATMKYVGELYMYRVINASVIFEILWSLLSFGHAEPMPFPGRESPIDAVDDFFRVRLACTLLDTCGICFPKGSQGRKLEQYLVVLQLYITCKTELPMDVDFMLTDTLDLLRPKMPKLRTFAQAAAAVDELMATVGDMGGDDSASEDEEERQSPEEKPEEPESVVENIQSVEDDDEDVVLIRDASKNDELDAEERVTFDRDFAKILADTTDTRREQRKAAPPIFDTAVPMVKKRIEEPRAKASNGNAEEEGRMQFMLMSKKAGKQQLRTLAIPVDSTIALNSKSQQAQSKAEQEQLKRLVLQNERRLERSEMEGIETRGVKLRFAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU25</accession>
    <name>A0ABR3BU25_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Solute carrier family 25 (Mitochondrial iron transporter), member 28/37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_103489</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614368.1">
        <property type="nucleotide sequence ID" value="XM_066757984.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990345"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="52"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="164"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="255"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="38438" checksum="280B05016D2E349C" modified="2025-10-08" version="1">MSPDSSSSKVPRFHVHPHGAHLDHPTPPIQAGESSVALEEEEHDYESLPVGSGWAVNMAAGAMAGISEHSAIFPIDSIKTRMQILAPVLHPVTGTTSATITGTISPQLNTISQHVRSISTTEGLRSLWRGVASVILGAGPAHAAHFGMYEFVREISGGRNDGWQGVVGTAVAGAAATISSDALMNPFDVIKQRMQIANSPYSNVLHCARTVYAREGLSAFYVSYPTTLTMSVPFTAVQFSAYEYLKALFNPSGSYSPSTHVIAGGIAGGLAAAVTTPLDVAKTLLQTRGSSADERIRRARGMGEALRIIWERDGWKGLRRGMAPRVLTVAPSTAISWMSYEFFKVLIRQHGSLPETGQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU80</accession>
    <name>A0ABR3BU80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn-dependent exopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614677.1">
        <property type="nucleotide sequence ID" value="XM_066757208.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989524"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="281"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="469"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="4">
        <location>
            <begin position="843"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="929" mass="101976" checksum="03470C12F6917FFE" modified="2025-10-08" version="1">MVTPHDMGAKDPEHPTNSPATAIVHISSKRGLTQLPLPNTICPHNNNARSGTSFAIRVTIATLILLWTLLNINVLTSPFKQTHLIGSVDDPSAAGYLRGVSTKGMKWALPAPNHQLQGTYHDGEGTEIREKGIETSLIPPKLAEKIFLDIPSNDSVAAALKRYTGYAHPAGSGYDYASALTLKNDWENELGLRVSGPLEFIYDAGSPESQARVRNGMDKLGVWIDTYYPVMNTPVYAAATLLTDPPFHAKLREDIVDGDSDSELRDEVPVFHGLSVSGDVKGNFVYVGYGRKQDFDLLKERGVDINDKIVLAKYGGCFRGLKVKAAQEAGATGVIIFTDPGDDGEITEENGYEVYPNGPARQPSSVQRGSVQFISKYPGDPSTPGEPAYKNASRLEGGNQPSIPSIPMSYEDVIPFLKALEGKGIHASDLGPDWVGGLGHHGVDYYVGPSDVDLHLVNKVNTRIMPIWNTMAVIPGHITDEVIILGNHRDAWVLGGSDPNSGTASQFEVIRGLGTLLKKGWKPLRTIILASWDAEEYGLIGSTEWAEDFGDWLQTNTAVYLNMDSSASGSNFHASASPSLALLVKSTAEEVESSSSASKTVFDTRFEAGNWEQFNMNKLGNHVGMEDLLSEKEGSGIGALGSGSDYTPFLQRYGIASSDLGYKSGPQDAVYHYHSIYDSFTWQKKFGDVEFHRHTDAAKVIGLILLRLADGLILPLNTTQYTRDLEYYLEKVQNISKIDLETSEIDFEPLAEAIKAAQTASGKLDKRRHKALKRLHKLMRKLEHGKGGIVKTMLRGCGWRTGGKEVEYNLQTWEEGPKEGIFPFPHPKLPFPLPTPRAYREINNILKEIRIINKKLQNFECGFLSEDGLKDREWYKHKGTAPGLWLGYGATTFPALTEAITIDHSSKLAQKEVDELAKMINKIAKQLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU96</accession>
    <name>A0ABR3BU96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613563.1">
        <property type="nucleotide sequence ID" value="XM_066758161.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990532"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090:SF0">
        <property type="entry name" value="SEQUESTOSOME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="659"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="735"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="975" mass="106900" checksum="BA410A93F61F65EB" modified="2025-10-08" version="1">MSKVTNGAIPDRPNRPLVIRCGYEGFSRRVNFPSAATCRLESLRNRVEECFSLSAAPYSLRYTDDDGEEFSIRSEDDLTEAISYFISGDDDAAMSNYSGSGSGVLPYHSSMLKITLRLDVVVEYDGPSLSDTSSISSFQTGSGSEHDSAYRSSAYESSYRGSILSMVQEPIEEEYTDEDDPGRNTARQSVAGHMSRMTLDDARLTSSQYSGSTPRRRSEINYAPPNDDFIPTQPPIPQPPLTGPDSASAPSLLTHSELGTRWLREQSNLAARKIGPSIKSKKSTTYDSDDDSTASDDERSGDFALVRDARGRYYYSYQTDVSSATASDVDFTDHEIASHRHSVQSSVLSSRSSPSPSHAHLHTPSLRASEQAGTPILAPDCSACGVRLDYLRYVCQTCGEGEMWMENAPGKAAFVPPTVSSESSQSDGSSDATEFAARATSSSSGSRTVYNTASRSRSGSISTDASRGSLQALAGSSSSPTNASYHFGVGFTPPHSPISAPDDLTSSLVQHDQPRRKTGYELCANCIEIHGIEHTKAAARAAKNELSGTELRRRKKAGELRHTFKERIWGAGGWDDVEYNEDSECTICRTTLFSNRFKCVSCPKFDLCRSCYQKVDEIHPAHAFLSLPDKPLPIETSRNAVNESGQPNLQVAGPQLVRHPGAFCHNCLQDIVGPRFHCAVCPSWDLCIQCEGIHTAGGDGSGHLSDHIMMKIPVPLPTSEIEAVSRRARDRWFQQDRTVATSGGDPISSLSRSYHSRSSSPAGDNSTLYAPTAIRAWDPSPSPSSQIVNVNQRDALDHGVRCGNCNEWIMGRRYQCANCPSDPVGFNLCSICELRSYRVHDPTHFFFKFDRPVHIPIRSYRPVLPLLYRHPVGKVPASALATINPREPTAYLKHVMHRDTLCDVHGDQIRGVWLRCAHCAGGFDICLEAERIADHDATHVFVVFKARVDMAAFRQLADLAATHSKPLLRQPVYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUA1</accession>
    <name>A0ABR3BUA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoside phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613860.1">
        <property type="nucleotide sequence ID" value="XM_066758458.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990833"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24039">
        <property type="entry name" value="ASKHA_NBD_YND1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="682"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="838"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="918"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="840"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="938"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="966"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="977" mass="103491" checksum="4168A46CCC796943" modified="2025-10-08" version="1">MAPSVTPLTTHYALVIDAGSSGSRLQIYSWRDPDLERAEILQDVKNIEREGSSSSSAGGGRWWWGGEDGWKGKGKGKGKEMEEVALRRLVRVGKGVEGDDWVKRVEPGISTVDPENVPEYLAPLLTHALQHIPPSVHSSTPIYVLATAGMRLLPPQQRDAILQATCDTLRNDYPFLVPGPTEDGPCGENVRVIDGEEEGIWGWVAVNYLMDGFGHAPSPSSLSNPGTYSSSSTNLLPLAPLASAPPESSSASITPVDIAHHSPTFGFLDMGGASTQLAFSPSASELLTSGFPPDKLRTVSLRLLSGEQVDWPVFVASWLGFGTNRARERYITSLYQRWASAHPSPSAQDLATPIPDPCLPKNLSVPPPLSSSSQPALIGTGSFPECLTSLHPLLEHSTPCPTSHCLFAGQPTPHIDFERHDQRGFIGISEYWYTMQHVLGVGGVWDWGEWEKGMKEFCGKEWGVIKGEMEDGDWEGVNMDPTRLEMQCFKGAWISNVLHEGIGIPRLVDAGGNDTLTGGLLGDTNVEAERRAREKGLFEGKGQGKQHFQSMDQVGETAISWTLGKVVIEASKAVQPRSTEMEGWWMRHLNLGSMRLPLSLPIPKHLEGKLEDLGLSAVWVYAVVAFFLVGMLFSRSNRRGGSSGTGMARRRKPSLSSPPLPVRPWFTFPSFLSGPAADPSLSIEDGPDLSPTSSTSSNSFSGSGTGGGSASGKLRIVPGRLRLWSLRISNTINKYLPSSLPFSLGNSNSRQRGAAHEMWSGIGLGLPRARHNSMPMIGMGSNTAPGVGLLSPSGGGGYSQPGSPRSVPTSFFTPASVPGIGGLNMGLGCLTPETAHTGISSATSVSPSPSLASTSSPPPPRSSLKSGKAGRPFKSRQNSYNLHPHHGPLGFHSVGEGVGVGVGGGGWNDPPLAMLSAPSSGVGPSGSGTADDGGVLTPTANGGLSNGALSRNSSRANLSELGLAQRSMSRTGTPGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUK1</accession>
    <name>A0ABR3BUK1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614801.1">
        <property type="nucleotide sequence ID" value="XM_066757332.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989653"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="88"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="343" mass="37264" checksum="844C060D7557713B" modified="2025-10-08" version="1">MSASAIPAYRHNSASPPVSSRKAVKASASASASSSRPPTRSSQDPYYGHEETAVLAARFITHLFQCPNIPAPSTPGAPTPALAYFVAYALHRTRLPSVVTFAALLLLQRLKRRYPAARGSSGHRLFISAFMIASKVICDDTYSNQSWGIVAQKMFTLKEINQMEREMCGYLEWNLNFGDREMLDFETDLRAVHGPKAMTRASSGPSYRPEIAFTDSPCKSYPTPEATPDPQVSSRPIRPVPSPYKSRFYSHVPPMAPAFPSPPPSPHHVHLSPQPPHLSSASSSLQSSPASDDCKTPSPITVMATARSIPCTKSFGMTKAFEASARTQGVSVVRRGDDAVTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV35</accession>
    <name>A0ABR3BV35_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614743.1">
        <property type="nucleotide sequence ID" value="XM_066757274.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989590"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="687" mass="74239" checksum="2829E94DAB58F80B" modified="2025-10-08" version="1">MSVSSQTTLISPPAKHTNPPLHRRPSQHARRRASLHVAHPHAHAHTSAHAHGRRGSEGESGRRALAAGLAMHTLDQGKKKKQGDRPLPRGNRSDTHLPRLTRTDSTMSIASHSSAASNISRPSAKSRRTTESIQVIDDQGKEVDPNEDEWESGEDVKQTKKGKGKQQDPSSASMRRTMSDTSADPKGKKKTQTMAEAMARGDLVKIQDPDHRPPLTQRTTGFAGTVQPLDPQIAAEMPQIDHPIIANPIKRVASSKSLVGPISTMTSMDTTPDSGFPTEPPRGLQSETSESKRPSAGQSLRSTSGSGLPRDSIDQRDQAQTDDKLTCSPSYPFPKMVSPTEPDQRVSRGADHPEKEISTASRSRPTSSKATHSLRHRPSNSSMRSIQSLRAPPHPLNSPIGYTGRSAARDSPSTSSYDKRDRVLSMHQPPVPQPQVSYEVAQGQGWDQIPEEGIQRENVPSSDQSNVDVGTTRSQNVRRSSVASTRSLRSIFAGTLVPPSTAPSSPQPHKRLTALEAASAASKRPTTNNPVLYHNSLSHASGSAESCFLISRFLPPKKITRPKWEVDIHDQERVEHGGVGLTNGDYRAAHETLVNTFRELGTGVSQHKRGLPRTPSGYGLLPTSLTLPNVAATAGASNGHQSNQNLGTIKARDGARLEVARGGSGGLTPFEMSVERVLKQRPGRVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVD3</accession>
    <name>A0ABR3BVD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">T-cell immunomodulatory protein TIP C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102811</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614815.1">
        <property type="nucleotide sequence ID" value="XM_066757346.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989667"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045405436" description="T-cell immunomodulatory protein TIP C2 domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="10">
        <location>
            <begin position="522"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="690" mass="75478" checksum="C707268A6BFA93EE" modified="2025-10-08" version="1">MRHSSLALLYPLLLLSPPACALWPFKEKRFKDEAFINAGSLGLGKLGGRIAAVGDWDGDSKLDLFTLSDEAKTVQIHLWNGDKYKYIPSHTLSLSERIINVVPGDYNHDGHLDLLLMYDKSEGGGWWGSKVERLGMGVYLGGGPDGGFQEESWTLPLSTASQPMVYDADGSLRPSLLGYQHTEAGEGVVSWRNNGTGFTLKTPQLRPLDEICILANPHSSAFIDIDGDCLPDLVLHCTRSNSVNFIQIWLNLGDAGYILARSYDLPPGSGPISFADTNRDGSIDIIFPTCTRKSSSTGLGRDCSINIAHNKQVPLCSTEVSQWNTDGLLKCRGWGDMCLSHEKFEFSFDESDPFFTSIPLSELISDSSNPGILLHAPSDPSIPLPLRPGDFNVDGFPDFLFVTSSGTKSSRSTQVKILENVPCAKGIIGCKKGVKRGWRLGHGKGWDALEGITDAVGASWLDLDEDGSLDIMVQRSGDQIGHKVTFIQNNFYHDAFFLKTEVLNGVCDGKCEPMAGGKSYNPLGVSYSGATYKFTVLDTAGHRVAQQVAQLPQTGYHALQTPYTFFGLGRTNNYVEKLFIGASLAPPNHITFLESLIPNSQVIINPPYPAAISSPDEEIEEPRSPVKTRSTEWKSQLYLKPGEWVPWVGAAVLGTVIALGAVVLGLNEREKREDERDRQRALHAINFQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVE5</accession>
    <name>A0ABR3BVE5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_101666</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614997.1">
        <property type="nucleotide sequence ID" value="XM_066756220.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988524"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="353"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="471"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="568"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0252277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="660" mass="73443" checksum="8D1A269C1C456A17" modified="2025-10-08" version="1">MSDNPERDVKIDDVAASSSSSSSEPHYTLSPHPPHADSSFHPLPTDPTPPPQPMSLREAPGPDVFPDHRPTLAEFRAKEGPAARASKLRALWKSLPPLPSIPDGDEPTPTQKMQLPGQGTTAALSPERAERLRRLYEEELVKRISEKRPDSSLWGGPDDLEPEMRNLKGKNIAWQDFRRFLWDKEKELWDIFQELDHNADGRLDAQEMRAALARSGVDVTPATVSDLVHFLASHSNKEGLPKGPPQEGSEEGLYLTFADFRDFLIMLPRKATPFEIYKFYQVRKRFSDGRGAARVDKEGDINISFPKAPNSPQTSTAAGFFNPPKQRKEEDEEFADTPGVYEEEVEIVQEDRHEAWRFLLAGGIAGAVSRTVTAPFDRLKVYLITTDDFSAFNRHPHFNHPLRIGFRAVTNLWGAVQRIYVDGGGLRAFWVGNGLNVTKIFPESAIKFVSYEQSKKFLAKYWDQVSDPSELSSSSRFISGGVGGITSQLSIYGLETLKTRIQSDIGPNQGWSHVVKTAKEMWRAGGVRTYYRGLTLGLIGVFPYSAIDMGTYETLKTAYCRSTDTDEPPVFAVLSFGALSGSIGAASVYPVNLLRTRLQASGSSGHPHKYTGFRDVLHHTLKNEGWRGLYKGLLPSILKVGPAVGVSWIVYEESKRMLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVR9</accession>
    <name>A0ABR3BVR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614385.1">
        <property type="nucleotide sequence ID" value="XM_066758001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990362"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="61"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="518" mass="56629" checksum="BCA73B3D0263C31E" modified="2025-10-08" version="1">MSLQPTSHPEPMTIEEKQGAQLDLNEINKQSFEGGRHTAGTDVEARSSKYAESDAGLVHKKEFKKAERRLLWKLDAAILPFATLIYLGAYLDRGNIANARLQGLQEEVLDGSDTNYSIALACFFVTIPGTLLAKYYLPSRSIACGALIWSIAATCQAAAFNRAGLYVCRLFVGIGEAMSGQATVLYLSFWYTKRDLAKRVGLFVAAGTVSGAFGGLIAFGVSNITNSSIPQWRILFLIEGCPAVILAVCVFFFMPTRPETSKYLTEEQRTICLTRLNGENNVEEVGVDWKAVKRAATDWKVYVMAVEYACINLTLGSVSGFLPTIIKGFGYSSARAQLFTVPPYAVALVFMLLLTTYSDRRQTRGIPIAVVFILGLVGWAVLLSVPATTHYSARYFACILIVTAGYANLPLLVSWLSGATANQSQRATGLGLINTIGQCLSLTSAFLFPSAEGPQYIKGASINIAFNALGLIIAAIMTTYFRWENRRRDKKEGGRPIRGTYLDVGNKYDLAPGFRYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVZ0</accession>
    <name>A0ABR3BVZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101934</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615262.1">
        <property type="nucleotide sequence ID" value="XM_066756485.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988792"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="779" mass="87143" checksum="C97C66FE7A3BE674" modified="2025-10-08" version="1">MPKEHIRKRGKRKTKTNDDAPLQPTTHVIEPEPSASTGIHPARAAMLAGQPIPVQAPSTIQDAQPDDDENEGGEEGQNQWTRGPRVDSEFPFGILDPDVKAYFKSIEEQIKDWEGVSSAGEEREDRQNFLSSVLSELRGHELSAATDPETSIILERLMPSLSDWGRRVIGDSFGDKWEELIRHRFGSHVVQTWMTLAADTLDRESKDIWPPQQTKEDPLAGRLPTMTSLFSSVISTLLPSIHRLISSPYASPPLRLLLLILTPCRVLPALGTEETANEGLIRSKKSDKWRKNQLVKGKSILGDDQSTSQSSNRALPDDLQPYRKEIRQALMEGLGEAEWKAMGVDAVGSPTVQLILEFEVNEGDAEKQGSLFDVLTEGMVTQICSNNQSVFEARPYLLSLITSQTGTRLSESILSLAPQKVFDAIWSTYFVGKLGKLAGHPYANFVVAKGVSRLELSDIEKLIEEVLGNSGGRGLIKAARTSVIQALVDRSLVLTDSQRAVFNLIESCLELPHDKHAFLVPCLMVLKTFPMYQSILAGEKATSPEPADGNMEDYDVQAEASFAAAARLSAWQNRRSTKPKDDLAPNMQGCLILQAMVGMEQVNEISLESLISLPIDSIIAYAKSPIASHLLDKVFLERSVPPRYKKKMMMMLMKSYKELVEDRLGSRVVDTIWEQADGYMKEKIARSLIPFVTELGGSQYGKFFIRRADIVLLNRRPDEWREKVLSVRHHFAHQKEASTTPFVGSKDDITKRKKAKDENDEIDRLFDSMDTRKKRRIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW29</accession>
    <name>A0ABR3BW29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SRP54-type proteins GTP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615313.1">
        <property type="nucleotide sequence ID" value="XM_066756536.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988843"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="10">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="671" mass="72105" checksum="7662971ED21AF7BB" modified="2025-10-08" version="1">MLDHISISHQSGLVLWSRAFTPTFETLANTPNSPINVLVKSAFIEGKAMTDGEEQGLEKDGYSVRWSVDNGLGLVFVVVFPALLPLAYVPALLERTKTLFLALFQPYVASLIESLSSGGASAGSALKQLKEKIVEERWDEVWERCFRSCEGEKKSRSVSVKQSVSDRINPTGSSADTSDVDVGPLSAEEIAKNVQSLKAKMKGGKRRGVRDGLSPSPSPSPSRKAPANAAAKLMRRWGDTPVTAEDMAALDYSTPAPDSLADDTASIDKGSLISSEALGTRNETGAYQVADWDFRRAPPASSQESLPSEEEIIARGTSHLSLNRATDDASNQSSWTSMFSRLTGSKILTQNDLAPVLVEMEKHLMSKNVAKDIAEKLCDSVGAALVGKKLGGLSSVKSEVQSVLSTSLTRVLTPKTSTDILLEIQRKRSSHLATLGTTSSPDSGPDPYTLTFVGVNGVGKSTNLSKVCFWLLQNGLRVLIAACDTFRSGAVEQLRVHVRNLGALGEEMGRGKGKRIELFERGYGKDAAGIAKDAIAYAKEHAFDVVLIDTAGRMQDNEPLMRALAKLVTVNNPDKIVFVGEALVGNEAVDQLTKFDRALRDFSGAGVGGVARKRGIDGIILTKFDTIDDKVGAALSMTYITGQPILFVGCGQTYTDLRQLRVNHIVQALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWC0</accession>
    <name>A0ABR3BWC0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615391.1">
        <property type="nucleotide sequence ID" value="XM_066756614.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988921"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046579887" evidence="2">
        <location>
            <begin position="21"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="161" mass="16036" checksum="7B5A6788D66A5F36" modified="2025-10-08" version="1">MSRLLCTLLFALLSVQFCLAQRLATRINENGYTVVITGPNGFDGTGTLPSSMALAMSTSVSTASRMTKSRLDSSTISSTPSAGAVDSWGGDVNAARTGSASASGSSSSSAASSASAAAKQANASAAMSHAESSATLSTPFNFGPVAIITLTSAISLWASVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWQ5</accession>
    <name>A0ABR3BWQ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615540.1">
        <property type="nucleotide sequence ID" value="XM_066756763.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989070"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="153" mass="17380" checksum="9C0DCFB8DB5BB4DB" modified="2025-10-08" version="1">MLARRSLLAARTLANPLRQLTLSLPARALSTATAPLSQSTSTTTTQYPQPGAAEAEFELASRREKWYHVMRTRQGELPVYAKYRNDGGCKTIVRKIEGDSHTLKDQLNEWFEQSHLDPFTRPPQVTVRPTNGEVQVKGHWVEEIKDFLSERGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWR0</accession>
    <name>A0ABR3BWR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615543.1">
        <property type="nucleotide sequence ID" value="XM_066756766.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989073"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="121"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="215"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="32037" checksum="40B635BB615AF9FB" modified="2025-10-08" version="1">MSPPADGKLGKGESGTARILGSGASGVAELLVFHPVDTVAKRLMSNKAALHTTSLNSIIFRSAATAPIHSKFLSLFPGLGYAAGYKIAQRVYKFGGQPWFRDLIDKNGGGWFKSTFGNKWGGMLMHATAGSFTGIGEVVLLPLDVLKIKMQTNPDSIRGRGLLKLVTEEGIGSLYRGWGWTMARNAPGSFALFGGSAVTKEFLFKLSDYSSATWSQNFVASIAGAVASITVAAPLDVVKTRIQNANFGSSVGGATIIKDMIKQEGVGAFFKGLTPKILVVGPKLVFSYTLAQSLIPFFGKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX60</accession>
    <name>A0ABR3BX60_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614628.1">
        <property type="nucleotide sequence ID" value="XM_066757159.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989471"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="1012"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1557"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="445"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="551"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1441"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="330"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1443"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1478"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1523"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1704" mass="185276" checksum="6AC45B805B25DA34" modified="2025-10-08" version="1">MIPDLGRGGFPVSNFDFQYTVTLLSTASLPVYSRPSAKLGKGNILQSGECVRERALLIRPNEQKFDAYLTMPRTPISPRSGSNPRIPPSSAAFLQHLHNDPSSHHITLSGHRASGLSLSPQSLTGDLLDVNGTQEPLISPPLRSHLSPVSSGASSGPPSLGSIDRVPSRRARPKTAPSRNDEWSPGRSYETSPDLPPPIPPQLDEHLRPNSIADLCSNAMTTEDGLADAMEALSTSEEPKAYLIGRSESLAGTAESHTGPSKPSPLASMNWSTFAQAYAHGLFDPNKIPNPPTLNDTPTEFQSAQSSPGQKYSSVPSLSHKYSMPIVPHNLSESSSENYSSKSSKESLSTNASSAPSTSSVSGSGRQMSMAASLAARKKAYELENIRDRPNGLALDKLGNDKLSLPSYSLAAATVRMASTSILNDLAPLSMPSPERELTDPLASVVSFDSSSTKKDSARSDPGSSRFPLHHSVSSAANPYTSSLRLPTIQASPVTTPLEGPHRPKGRDKSPPRARHGIVNSRIPSASAPLEKTVEAESSTDYFGAAAVNAVSPQDTDSSSTATATEPTPTGPSSEMRKTTPLRSNVIVSEPSPRQQKDPLPLLVNSSDVNRIYDQYGWLPAPLPPDETARRRALYRFNILHTAPDINFNRIAHMTKLVFNPKAVLITLIDSDTQWFKSQSGFTVEQSKRMSSFCGHAILPRTDEPFVVLDASSDWRFENNPNVVGRNSIRFYAGAPLRTADGFNIGSLCILDDKPRTEFPPRSRLILKEFAAVTMREMELWRDKLQLRVRDKIQTSMEKFTRECLEMDTASSTSDAEAANKMEHVYSRAAQLVCSTIGLDGCFILDISQIEMVQADTSTGKKATYRANPYGTVENTSPVLERSESFGPVNPFPVLAAVPTAKSTRALTSYEHEKLSDFMQNHHDGRIFEGAAPQWIRYMFPQSFRYGMAVPIYGVDQQPFAMICAYTANPEKQFLEGYELQFLRAIGVIILSAVLRRRMVLADKTKSILISSVSHELRTPLHGILAAAELLSDTQLDSNQLSFLKTVQTCGNSLIETVNHVLDFTKLSGTQSSKGSPGDLGKVNLAALVEQTVEGCWIGQRARFFMGDSDIGSFYAPPAPTRIVPKSQRALVGEELSHVETVVDIDMRERGWVVRCEKGGLRRVLMNLVGNSFKFTKNGYIQVSLREMPHEPGSKTIPVEMTVVDTGKGIGKDFLKDQLFHPFSQENPLQTGTGLGLAIVNTIVRSDSVKGKVDVWSAEGVGTEIKVTFEVEVVDDDDGQSSVSSNSSAVSASSTFGLGLSVSFVGFDPKHQGHMLSCEVFTRYVDYWDFVIEDQQSADILIVNELQELAKHPVAAQKPVIILSVQRGFESTTLAETINRGGGFCRVVYKPVGPSALQKALNAAVHWIGEHDLSDKSGALGGLGVDVTGVDVAGNFDRPLITRGSSGESQESHSTISELSSVRFSQQSNNSRLPLQRRRSEENEQAPKRPSLAPRGRTYHSSNKVQRNGDDLAGSVSAQRPASPTSSIPTIPLGDGGVMLKAATVSAEAPRKKKMGRVMVVEDNIINRRVLGAFLKKRGFEYAEAVDGQAGVELFENAPPNYWDVILMDISMPVMNGHQATRAIRRIEATRKNNPSDVPPVPPPGRPETTMLQKAVQARAKIFALTGLATPDDKREAFRNGVDGYLVKPVSLSSLDIILKKIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXV2</accession>
    <name>A0ABR3BXV2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614853.1">
        <property type="nucleotide sequence ID" value="XM_066757384.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989705"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="506" mass="55997" checksum="338A75F615E2908E" modified="2025-10-08" version="1">MKDKNCSYASRPSMGLMRNGGGSGIKGWGVAVQLITLLTTAHTPPPSSAHSLPFPRHPPPISTLIPAAALPTRASRSSPPKLSSRDQTLLSKPSVKGWSLYPLQGRQLDKRYPEWSIHGWHEDAQRLLQPRQAMTPSNVYAKLRPISRGSYSSGSHFDKSSRAHPPPGWGENMDNTSQTFASPSLQADTRHPLPLRPINSEAKLCERSYRLITYGTELTEQENHAMARALDTGKESSGRRTNFGRSPSGKMRSIVFAPNTPPSCHPTKSIVLCTENEWSSSITRSATNHPASHLNVTTYRSDFHQSSQSPVAPKAAFEEDELDSTSSSSSCSSELSGYEDNDDFESSDKSGEDFPIKLRLRVPHLSSIPSTSPVKSIDSENVTSSSSNYTPTSNTKRTRRLNSTSTPSPIPLSSWGEERGNEVLKDSRQKEQRRNRERGGEQNAMAQKKFRWKKKQMAEKMAADLESANVTTSKLQKQLAERDSLVSDLQSELSLYKRKFGECTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BY38</accession>
    <name>A0ABR3BY38_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102972</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614943.1">
        <property type="nucleotide sequence ID" value="XM_066757474.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989828"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF218">
        <property type="entry name" value="ZINC FINGER PROTEIN 502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="674"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="520"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="614"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="702"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="804"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="176"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="749"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="824" mass="89917" checksum="42F2EF20C6D5313F" modified="2025-10-08" version="1">MSHSLYRHDLPPHFCPPPTLLPDSAVSPTLKCAYKVPRSLGMVSAEPYRSQRTSYYSQPQSPTYVSSTSTTLPVSGALIFTLPFQQIDTVSPVGKMARRSSRADPMIRTEDDMYEEDDGYGELGQRHPLRRVKEDMREEIEERHEHEVQLTRIQEQGEGMSLPGIKTLLGVKEHPSGSSSLYQSPSLPSLGTNSPTTSPSSARTSRFSSFTSSTVPELSAPEWWAPEFERSPFHAVFSRPHPFPNTQTYMVDEHDQKRRRSDGPPPLRDVEESARLRWQAQSRNASFPSAASHSSGPTTPTSWSLMRGRLHPPVPSSPSIATVMGRGSISSTSGAMSPPITRRASPNSRNPSLVGGQLSRHISDLSATDSQRGSISGVPGPPERRVSVQASSCINPIDLDRAPVLPPLTSPENERPPMPSASFSLPSIRRSSSTCSDRLRRHSNTQPTTPDTTGLPEVRRSSLTEIIMAKSGDDVAMKEGRYGFSTEERHVISGTEKRAETLSGLASIPLQSKPAIQSLAGTSSDTRTWNPQERRESTESISSATAHLAINSEAERERTVSLRGRKRSTDTRDDDEPKVDSSFIGVDVGVGAGDPALRGMEVLAESARRVAAAEEEQKAKSVEEEDVEEAEEEKDEVPEKTGGPKYTCTYCAKTFSRPSSLKIHTYSHTGERPFVCNEAGCGRRFSVQSNLKRHAKVHLVGPLGVSASEPSEPLTKSPERPTHSSNPHQQPSPHPPPPHHHQSHHRMAQPPPPHMMSGPMPPPGGYPFIPTSYAPLSVGVLSGPPPSGSTPGMAPPHGYYMDGRYAVAPPPPSNGMHHGQKWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYB5</accession>
    <name>A0ABR3BYB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615236.1">
        <property type="nucleotide sequence ID" value="XM_066756459.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988766"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF72">
        <property type="entry name" value="IM:7136021-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="570"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="119"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="81436" checksum="162600186CD38759" modified="2025-10-08" version="1">MRNQQLVQQHYDIALKFMQTANYLDAWKNFDKAINFGGKSPVLLDCKAAAMSKLPEWRNHALEVTRDMITKWPKDFKGYYRQASVLYAMKAYDHAFKAINKAVDIGPTQSQNERQYKAIQELRATIIIQKAEADRLRAANDEAEAQRQAIARQAAKKARINYTHLLSRDILLTIAEQGTVDHPGFIFRMAGVCKSWRETLLNQPSLWNTIVLGKKRPDQKVTLFIERSRGRIREVKITRQLETALAEKIATSLAPYMPNVERLTISGDSLVSSVVFEHWRYFLHSVKYLRVFQVGGGFRTGENVIYDLLPPGSLSLRHFDISNFSCLLMDQAGSESNPAYIAYSRVETVSIRSTYIFLRKESAEEMLLSNFPAATSIELLNNRYIESSDEKPLVITSELPNLRSYTNNHSTSNVFKTIRAPSLQGLSVPSLRARSLKTWLSAPGLASCLTTLRSLDISSTSFTDTDILSALAFLPGLQFLNVSACPLSNAFLEGLARRPAGSDQENLCPNLIALSIAKNDQITGGPVTRFVRSRVPGGGAALVSDSDTKEQGKITTRTEVKKSVSSSFRPSARSAFGRPTKPPFVGKDSNQSIPATFPPNETCAVSQPPPPLSLPSSSTLPKIRWLNLDHCDRIDPSAISYIRKYVKFVGYSFGTPDANRIAGKGRWRWDAQWREECDTGEGGCGLRRVAGTMDQWYVYHTCEPDVVEEERSWTKVVSLATISVSFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYU7</accession>
    <name>A0ABR3BYU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615792.1">
        <property type="nucleotide sequence ID" value="XM_066755506.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987802"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF16">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="649"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="742"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0253571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="811" mass="88162" checksum="6708F9E01C531E3A" modified="2025-10-08" version="1">MGNHRPLESRTEDISARGMLNDEYWSTFTFNSDDYELGPVIGFGASSTVYSALFTPPNTQSPTSPSACSTPAGFDHSDSNPTLQSRHTFPAPGTSRKPHLSITLPAPSSLPTALVSGALEQGTSSHSRGDRPCAIKVSSSHPDVEQLFKEIRLLALCKHPNVLRILATFTLPPDYQRIALVTPLISGGSLAGILDWRARLATTPKSNHTFKFGIGHKRKDEEDGHTGLEEEEIKAITKQVLDGLKYLHERGYIHRDLKAGNLLVDDDGTILLADLGVGGDMNLPPSPVSEKSRRTGVEEIRFEPTMVNRLGPGKAASMTPTEEAWGRRKSFVGTPNWMAPEVILGRRYDDKADIWSLGITILELAYGTVPGSKIKGKDILTKIITEPPPALDRMGKFSRHMREFVDTCLVKEPDGRPSSAQLLEHCWLKGAKKKNFLAQSLLDGVPHLAQRQELRRIPTGSSFVSCTSSWDFPTLSRPSSPIKSSLHNPLARSPSIISYKGDYFASHTHSRSSSFSVLPSSPRVSLRQWAERSASIEGEYTVGLGIRTGSEKGKTRSSSVAPAYSARKTTSFDLPAPTSTPSSSRFIDGASSMRRGRELGAMRLEDSTAQDDERAIAPMSPLMEVGKTEAHPTEIPPLNLNENFAGLEIGGDGLEMRGSPEPLPARPDDPESIPPAEIPKETSTENDDGAAAPEFVRMSETREDTSSITRQTEYPNTGASSTNPFSGTETLLARISSRITNSDHGEKRNWLNKRSSLKKSEKMSIATSVQEKDKSGLGIGAAPGHSHSHSIGRTGSWGAVFDKMTGKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYZ5</accession>
    <name>A0ABR3BYZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615837.1">
        <property type="nucleotide sequence ID" value="XM_066755551.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987848"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0253616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="447" mass="50843" checksum="5C8A8395D57DAB72" modified="2025-10-08" version="1">MSTSAAEKEHWRSVLRAFDGYMRYHLSANHARRMAFMTLPKAEKEVYELIGYREKLEAVDEGIRRNSDFIDEMIANPVFSDMISSSECGQRAPGDYMHSHVDSPLHDHSHSVSPAHSHSHSSSKSQSSKTEGKRSPELDTAQDKVRSTLRSFVRDWTREGEDERNACYVPCLEALERYFPQKGDTGEKVVEIMTDEEDVKLCRKTRERSEVKVLVPGCGLGRLAMEIAARGFFSQGNEFSTYMLIASDWVLNQTTTAESHAIFPFLHSFSNHPTTEHHLLRSVRIPDVCPVDIFSRGRPGPFSLVAGDFEEIYGPNNWDLHGGKQHDFEDGENHQGQWGAVVTCFFIDCARNVLNYLRIIHSLLANDGVWINVGPLLWHFENSPTTSAKGEGSVELSLDEVKELARRIGFDLREEKMIRSTYTGIPEGMLRHEYNAAFWVATKRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ77</accession>
    <name>A0ABR3BZ77_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615912.1">
        <property type="nucleotide sequence ID" value="XM_066755626.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987925"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="405" mass="39345" checksum="D715454ED1322274" modified="2025-10-08" version="1">MSSAPGTGSAAPTSDPVTPSEVASSAVQSSAAATSSPGVTSEPQSSAEPTSSSGGSSQGSASPSASPTPSPSSGGSTTNPGSSAQPTSSPGSSSASQSASASVTASPSGSSGVTSGAGGVSSTVSGFTSVSNGSSVVYVTVTNPDGVVTVSPTATMTGGSSGSSSSGSSNHTGAIVGGVVGGVAGLALLAIVLWFLLRRRKSHRDDFDDMMFDPGRPENQAPIDLGQDGGAPTVEPFYAPGVASTAASPEMSQYPRSAATISDGGYGATSSGGPAPSIATSAGFAGRGAGGQGMYDMNMEPMPMPTAHPTGVDAAAAAGAAGFAGADLGAMGAKQREAFQEQQRFRVQNQGLAGSSGAHAQPMSPTSTDATNVTVHRDAGAIEDEEESYNNDEIPPTYESIGRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ79</accession>
    <name>A0ABR3BZ79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615536.1">
        <property type="nucleotide sequence ID" value="XM_066756759.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989066"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="436" mass="46238" checksum="2E0869348477013E" modified="2025-10-08" version="1">MSSNSYQHEYVGENGNYASSSTSATYDLTKASSVYTSYDSHPTSSSSSPLSYYDNSYNYENSGSPAIYDNISPTTSSVATSSPIGEVIGNATTSVTASATADDRPHVMSLGGVIAVAVIGTLVIVGAVTFCCFYTRRRRRLNKLPGDVDVPTRKSEGGGRALERIETPTLRSTSTLRSNALRPPSHPRMSQRDVRGVVLPQRPLPSAYPSSSFPHLSSPFNDPLTSSTSGFSHRRPESEYTDNSEFDMLAQDGSSYARTLSTYSEGVNSEYSERDLGTYVAPSSQVTVMGTRPRLAVDTKNMSNEGTAVWNYTAVDSGGSSGWGSGPGSGSAHGPNFVISPFIDPPYLTSPPHLPPSQATYLTQPSPSVVSDRSWRTEDDALLINSGGSVGSGSRAAGGSGTGSGLRRGMTIVRHTDAGVVKDEVHLPPSYGELYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZQ0</accession>
    <name>A0ABR3BZQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616071.1">
        <property type="nucleotide sequence ID" value="XM_066755785.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988086"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36812:SF9">
        <property type="entry name" value="MYB-LIKE PROTEIN X ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36812">
        <property type="entry name" value="NEUROFILAMENT TRIPLET M PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="300"/>
            <end position="323"/>
        </location>
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            <begin position="336"/>
            <end position="353"/>
        </location>
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            <begin position="394"/>
            <end position="405"/>
        </location>
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        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
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        </location>
    </feature>
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            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
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        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
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        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="654" mass="70401" checksum="06D875A7000CBB5A" modified="2025-10-08" version="1">MPQLTEIEVLTYYSSVVCGLLQPGSSSLISVPKVGSRQDVVEDINTESPQNALDYNVTKKEKKGKGKKDNHDATPAVEPSVKPVEAVIAVATPKDKEKQSKKKNKTKTLNAGLPTAEDLEQNMPAPNDRKQQKQSKGLPQNAASGQTEADQAPAHQVPPQLQSTGVMLPTNASEGNKKSTKRKVDSAAAVSEVPHKKTSTRTDKEEIEGQTPAKVKPRKSKGKEKDVAAPVRDAEPAAVETGHGKEPAKAKPRKSKSKDHTASARIPAAIINSGTSNVAGSSSKPSKSATTAPIPELPASPKSITPPRSTTPPRSFSRAPSTPISEEDVLRHLYTHLSNSSGPSVASPPTLSTPEVRKRRRESMVETPLRHKVLSRPMESLGKKRRMSAANEYIDAREEGEHMMEEVDMLASPAVSTATVAEKKEKKDKKKKKDKMSAPLAESSSNPSLAPISDETTGLPNFSELRKKDKKKKKEKKEEKQKEEKEKQEREKIEAKEKRKGKEHGKERKRKSEAFQAEISSPAVAPAAIPAPAPAPAPASAPALVSSTPTPKQKIPLASSSKKKRRLTEIPIPRLSPSVKSSAAATTAESPTSSKKTKLSQGRIPLGTSPDAAKMHMYASMGIVTPSPGSKGSSKKEKKIGKKGPKWITETPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZW5</accession>
    <name>A0ABR3BZW5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616153.1">
        <property type="nucleotide sequence ID" value="XM_066755867.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988168"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
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        </location>
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            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
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            <begin position="638"/>
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            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="892"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="962"/>
            <end position="971"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1116" mass="123643" checksum="0C4C201E5DDB977A" modified="2025-10-08" version="1">MWLLTVVGEILGQKHYTFALQQQKSYTFGRNKDCDIAFPNNLRVKPEEGALEILDWDYTGRHSRPDIKWRPKPKKNGDYGSIVAVGKRSETPPGSINKGHYDVVPINNEKGNGIFVDEVNVTGISFTDDIWFFLEWRDLCLLYGKMMDEPGAIRNTLKSYCISWTTTFDMSDPPQYVLLDAYRNNWEAKYAVCCGIPILLPSFLTLLQSRLTANWRKTADAFCSFKLPLPGEDEAEYRPKNHQSIKFPSSIWLPDKRRRTLYRGWHVLLLREQIQPREAFMYKALGADFKEVIVEGNPPRTSSDVEKYLEDWLSYLDAHGGRKKSLVAYSVKVKDMVNVKMIEETCGRLKINCASVASAFGAVLNGGVQQFLEGVDNKHNRHATRGSTAAVTPVASSSLPSSAADPFRRLTETPTPALTPTPPSESNPSSVPNVTSAVAGSSNALNVPSTFPGETAPPMPFELPRLLRRRTAYTKPIIADATPVPAASSEPQHATVDPAGTEGTVDEWHPPPVPVLRRPQRRTVGKGARNPPSSIPPQPLANHQFNTTDTHITSFEPHPSFAPNSMSSQEENSPQIAPGSSRAELSDFPSSTQLNTVPPVQTIPRPSRRYGATMSIARPQAGPSMISFAGPAEEEEDDRLKELYEKTGKQGFGPPSLVKKGRAAGRGGDVEMEDTQISSVASMTDRERYKAPSEILHIDEQPEEEEEEQDLFAQTTRRSKRAASAAGLSTTQGTESHVRSRDIGRTGSQGLMPPPAQRRRIQSSSPSPEPEPSEDLAPRRIVPSQNRFDFQDAIPQPITRDEEFLRVVAERKKAKTAIDDLDKSFDSMLRIPKAQTQSEADKPDYSVLDEVPPPKAGNYIAVMRTSNLFRKDLGQAKEAENVDDGKPNFKEFRKKNVPRRAPLKMVLTTSVIDPSRYEEPEPYWPTQKKTQKKSQAQSGSLSEAEEDDRPLLPKRKPRLLVEDDNEQDGDVDFIPTGQTAGRRGTQRNQVRDNPATLGIFTQRTRRGGSVASDTYDIQPARSDTSKTVTNKTAPKATAAKGRKKQLVEDNDTTIDWGSAPSTAKGGKNSFASSGTATLDDDPSSTARKGTQKRKALTVHVDDDEGGFGNFGKRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZW7</accession>
    <name>A0ABR3BZW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I308_101303</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616146.1">
        <property type="nucleotide sequence ID" value="XM_066755860.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988161"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="18">
        <location>
            <begin position="60"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="536"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="536"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL0253925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="596" mass="65542" checksum="7C677A35D02660F2" modified="2025-10-08" version="1">MSSTAAVQVINSEGLQSVGKDLPTPTQKQFPTFPTPGKPKHEKLGGYDFYRSIGSPKFVVAPMVDQSELAWRLLSRSPLPPALAGPSETVKTPQGKTYIRHAGGAHVCYTPMIHAKVFVDAKGEGGRNGDGQFCLSLDEEGGEGTIGGVEGGDRPLIVQFCANDPDILLAAAKKVEHRCDAVDINFGCPQGIAKRGHYGSFLQDEWELIHKLISTLHENLSVPVTAKFRIFPDLDKTIAYARMMEAAGAQILTCHGRTREMKGQNTGLADWEYIREVKKAVRVPVFANGNILYREDVDRCMEVTGCDGVMTAEGNLSNPAIFMPPDHPYAHPPITLLAHRYLDIVEALETPTAGSAIKAHLFRLLKPVLDTDEELRVQIATCRWSEGMHGFREIIRDIERRCVPVREAVGGADWKPPAIDPKTGYRSLPMFAAQPQIRAKPVSTEIGGHEDMVSRPASPGQDGKEDRDRIFDVPNITTAPASSVPGTILFSRSHRHTGLAQTERVLRAVEAGYTREEAEAESAKGGLVGMGCDAHEEKVRARKEREARKRKGREMAKEKAKVRKKEEKAKAREEREKSKEKVEMTEEEASFASGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C054</accession>
    <name>A0ABR3C054_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_101336</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616178.1">
        <property type="nucleotide sequence ID" value="XM_066755892.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988194"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="204"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="461"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="58"/>
            <end position="67"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL0253957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="516" mass="56903" checksum="D834325C8AFAC904" modified="2025-10-08" version="1">MFQKVSDKFHRKQQSSTSSGRSQQAPNPTGTVLAKANSQTQQAYSLPQDHSPMGDIQGDSSLIQQPMATEKAPVIEPSASTSSSTVTGQGGTVLSALGTQGMLAAPTEGPRQLQSPVSRASSADEDRMREKARGAQEQAAQAQANLHHATQQARVAAINATATQAALETATQQPATARVPTSGVGAEPGQARRKTAGRYALSDFLIERTLGTGSFGRVHLVRSRHNGRFYAVKVLNKEKVIKMKQVEHTNSEREMLVRVRHPFLVNLWGTFQDVNNLYMVMDFVAGGELFSLLRKSQRFPNSVAKFYAAEVALALDYLHSLDIIYRDLKPENLLLGADGHVKVTDFGFAKYVPDITWTLCGTPDYLAPEVVQSKGYNKSVDWYALGVLIFEMLAGYPPFFTEDGNPMKLYEKIIAGKVRYPTYFDGLAKELLKNLLVGDLTKRYGNLRAGSSDIFAHGWFAEVDWDKLYRREIPAPYVPKIDGEGDASQFDRYQEADVSAYGKVGNGPYDHFFLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C055</accession>
    <name>A0ABR3C055_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_066755953.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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        <property type="entry name" value="Thioredoxin-like"/>
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    </dbReference>
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        <property type="entry name" value="GLUTAREDOXIN_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
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        <source>
            <dbReference type="EMBL" id="KAL0254018.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43489" checksum="12D1837CB387A27B" modified="2025-10-08" version="1">MPALNRQSPSDTTSLSTSSASVSDRSDYSPTSSITSSEMRLSDQLPSPKFATSRGFSLLPPSHPLRAQLCTQVEGEMSPPRSPKGHPIDQQSKSYFPLSSRATKHNSKGITNPYGSDNPSYPVSITYLLRIPRRLRPYLLVAFCLFTFSFILLNRAVSNSQYTEVIAMQKPPSHSAHRYVPIEELQETNGRDVQVKKKDAQLLRFESGEEELAALISFVTSTTSNVIPHLDPSVPLDPSVILDFDPSHPNARDDLLLLQTEINALYPLVLYGRMRDPRYREIKRLLSEVKITPAPLVIEVDQRKDHKVFIPTVARLLGDELPVITLQGKKLGGYKEIMAMHEAGTLKDRLQKDGAVLVRELKKKKKGVKEQERIENERVLGPAPVADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABR3C059_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chromatin structure-remodeling complex subunit SFH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615629.1">
        <property type="nucleotide sequence ID" value="XM_066756852.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989160"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="68923" checksum="2799CD7A9D075CE6" modified="2025-10-08" version="1">MAYSTRTRVSTPSIQNTYTNRTSYTSTRPAPSPAPVPVLSHQAAVYQHPQTYPPGPCPFFLSPPGQKTTDPSLSTQPTSQALYTTYPSRLRTGVTGLIQPERVSGGPKERKAFLAELDREMPFGGGINTPGYGRLSGSGTSTPRFDSPAPFPSSRRMTTASAATGAGLGSSRRGRVVNYAEKGSDDEDFSEEEDDFGEPASDPDDIDYGSRRRRTAGGGSRRESAAPLVVGGLEHQAAMRAGKLRRKMEELDRGWTWLGDRTPGDRVRSQVAGVTKHVYKSEDELQKEAERPEMLIPITIDFDVQSAHPDQQGLKIRDRFLWNLNEPFITPYQFSIIFCEDVGIPISPYAQRIQDLIEKQIEENQNAAEIDVTNEDVTESDVVWSDEEVEGVMDDTFENGDGNKDGDEESKEKQIEEEQDQEEAQEQEQGQEQKEDKKRSKKRKREGKDEKGRNWAEPDCRVIVNLDVQIYSYLLRDRIEWDLSSPLPPSLFAKHYCTELGLTGEAIPAITCAITEEILKHKRDALDLDLFASTHPVEQAKWEKGTTQPRVSVNQKGGAKALVGVWRDWWEREEFGPVLVELTMEEMEKRDMERTREVRRNNRAGVPLKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C073</accession>
    <name>A0ABR3C073_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616259.1">
        <property type="nucleotide sequence ID" value="XM_066755973.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988275"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035195">
        <property type="entry name" value="Emr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17237">
        <property type="entry name" value="Emr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0254038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="91" mass="9846" checksum="867639B9AEC1FB3A" modified="2025-10-08" version="1">MALPNLRSIFASSRTSEEERQLSRTTFYKFIVLVTVPLSSGLVCERCCGHGIGGARQTCVKKEKGIAPSEVGLSTKKGLRTLDCSYLAPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C075</accession>
    <name>A0ABR3C075_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616248.1">
        <property type="nucleotide sequence ID" value="XM_066755962.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988264"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046617273" evidence="3">
        <location>
            <begin position="21"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="285" mass="27539" checksum="2B5AB9CA555CF64C" modified="2025-10-08" version="1">MKVTLPLAITVSLLSSIALASPTPVSVGSATERGLARSGDSISHDVVRSLAGAFDASRVNAVKRQQDTSTDGSTDATSGNDGTTDSTTTDGTTTDSGATDSSTTDSGTTDSGATDSSTTDSGTTDSGTTDSGTTDSGTTDSGTTDSGATDSSTTDSSTTDSSTTDDGSTSDGSTTADSTDNSTDSTATDSTATDDGTDTSSATPTIAAAANTTSTRTSVTDYNTTTRSGSAAASTTSAAQTTVAVASANSKSGSGRGISVPSGLSVISILSFFVAGGLGAAHIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0D8</accession>
    <name>A0ABR3C0D8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_102378</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615704.1">
        <property type="nucleotide sequence ID" value="XM_066756927.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989235"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="773"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="848"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="978"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1010"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="14">
        <location>
            <begin position="311"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0252984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1038" mass="114714" checksum="8C8BC108C0F323C1" modified="2025-10-08" version="1">MNPGDVYQPPQGYNAYGSPTRQNQRPPQPQPPHLPPQQPPYPPPHQPAVQYGDPFSASPQRPPTAPVQNMSPAWQEPQGSHHHASHPLQPASPTGPQSPRYSLPTQSMSPFNGSPASAPAPAPYIMGSPSHAHAPAIPASSPQHTHFNMNPSYSLPQQQLTPSYSYPNGIDDRLTSPPPLMPHHSFHSSISAIPAPVPDNVNYSPSYPPQGYGNTADDDMNDSHPLLAHAAPDPRFGIPQSASAMSMSAPAARYQLSDTGAGDMGVPMYTGNGDAEGQNGFATGDGIGADDEDGVNMHYGPIPARMVRRNRTQKRVQLFQGHLVLDVEVPTMLLDQCPIRQGNEFTKMRYTAVTCDPNDFVEDKYTLRQRLYDPPRQTELFIVITMYNEDDILFCRTMRGVMQNIAHLCTRSKSKTWGENGWKKVVVCIVADGRKKINPRTRSVLAALGVYQEGVGKNIVNGKPVTAHVYEYTTQLSINSSGKIGPGGPNTVPIQMLFCLKEKNQKKINSHRWFFNAFGTCLRPNVCVLLDVGTQPGPDSIYHLWKAFDINSSVGGACGEIVALKGMFWKNLLNPLVAAQNFEYKMSNILDKPLESIFGYITVLPGAFSAYRYIALLNDEKGNGPLKQYFVGETMHGSGAGIFSSNMYLAEDRILCWELVSKRECKWKLHYVKSAYAITDVPDTVPELVSQRRRWLNGSFFAAIHSIVHFGYLYRSSHTFTRKFFLHIELVYQTLNMVFAWFALGNYFIAFFVLTESLNSLGSAWKYVNTPLHYIYIALLLWCFLLSLGNRPAGSKIGYTLSMVGFALITVYMLFAAIYLAVKGVQDVEAQGDITASTVFGNKIFRNIVISLLATYGLYILSSLIALEPWHMITSFLQYLLLAPSYINVLNVYAFCNVHDVSWGTKGSDKVSDDLGVVKSSGDNKDEVTVDLPIEQKDINAVYAAELQILGTKAPKEVRVISDDQKQEDYYKNVRTNVLLAWTMTNGALVAAILQTSGGDSSLATTYMGILLYTVAGLAFFRFLGSSAYLVVRLFVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0E5</accession>
    <name>A0ABR3C0E5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616324.1">
        <property type="nucleotide sequence ID" value="XM_066756038.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988340"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF71">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="644"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0254103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="949" mass="104090" checksum="EF3D8C4748C79F99" modified="2025-10-08" version="1">MPLKKKSSVKNKKTRRKSRQPASDSSVLENDHTLASSIPPSPLATPTAEPAQTVQPLQLTPARDEGPRAEHDKEAMHFHSQPPLELTPAEPGTLPSRASSALPALSLAHTRLQGSSPSEIARLPPQLRNFLSSPKSSEEIDHVINLFDASSVPFDPSSLYNRNRSSEDVENMLMEEYRARIRLHGEKMKSNGQMTMKNQDPALLKPGVIPGVYGRNNHHHVCHAPLPSFYEGMSGLGIDMGQQSPSDCLHAPYESESMLTPRGVKETTTSEKTTMSSSRLEFGGGLKSDENGVINERKKRKNAKKKEKEKEKKKEKQAAAAAAEVPKESKGYDQGEAVVQMAVKEDAGWNAFKETTETYSEADGGILFSPSAESATAYEKLVTPLSAHEEKLPTPSPVNEDGTTKSEVLVHERQVENKIVVTITSFENPVEDDLAAFAANLSYEYSIGTPTTPLSVPASPDEISNRKFGSAAGKIRTFAPFDNSGNVAGKEDQADQKQEGETSASQEGLIVIVECEEEPLEESRQAGLQIIPEARELESVKRTDEAKNPTVDSRGSPKIESSGPDSKSSEFPLVVREQSTTIYRIPSELSNCCPNSDAVMALPASQDSNQPEDNHLSPARPVFLVERRDQTVVVESKYDNTPRSVALKKTMSTPVPLERPSHNDCQQDRLTSISLRRNNSWGKNRRRPSYSAQSSPEKQKPRPLPGYQHMVEIPSLNLVKPEPNLLSQSSSMNNGLNFSRPLSLPSSPVKAKVGPLPQSFPLERSWTMYFSDTSEKGQHKHRLHLQSAHEYNSGLVTVFNASNLEEFFGGWKALRRVIAETKGRDIEPRGMSIQGGAGLGADLMNDDTNLHLFADGIKPMWEDKMCRKGGKFMMAGDAALMDNVFLEICLLLIGGSLSDAVPCPPGARAKSIICGVAISRRKMTRLEIWLGGENGPDPVLFPYKPFGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0F6</accession>
    <name>A0ABR3C0F6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616335.1">
        <property type="nucleotide sequence ID" value="XM_066756049.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988351"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0254114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44226" checksum="1CC9118C6FB7F00B" modified="2025-10-08" version="1">MVKETKYYDLLGVKPDADSNDIKKAYRKSALKHHPDKGGDPELFKEMTHAYEVLSDDQQRSLYDQLGEAGLKEGGMGGGVDPQDLFSQLFGGGGGFFGGGGGGRSSGPRRGRDLVHRISVSLEDLYKGKVQKLALSKSVICKTCDGRGGKQGAVQTCTGCQGRGVKVMLRQLGPMMQQIQQPCTECEGTGEMMNPKDRCKTCSGKKTTQERKVLEVHIDKGMKGGQQIKFAGESDQQPGTIPGDVIIVIEEKPHPRFERKGDDLFYNAKIDLLTALAGGDFAIEHLDEHALHVTIVPGEVIKPDALKIISGQGMPSYRHHELGDLYVRLTVEFPNTIPVENIPLLEKALPPRNPMPKFNKKIHIDEVVLSEPNERHAKNAASGEDEEMDDEDDDGRPGVQCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0F9</accession>
    <name>A0ABR3C0F9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616130.1">
        <property type="nucleotide sequence ID" value="XM_066755844.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988145"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="356" mass="40181" checksum="5EFB32BE751E0312" modified="2025-10-08" version="1">MEALGFNMSSGYLEGVVRGYKGALLTQSNYHNLTQCENLEDFRLQLSSTDYGNFLANEPLPLSTSTIADKATEKLVAEFHYLRTNAVEPLATFMDYITYAYMIDNVILLTLGTLHERDTHELLERCHPLGVFDTMPALCVATNVEELYHSVLVETPLAPYFQDCLSAQDLDDLNIEIIRNSLYKSYLEDFHKFCQTLPAPTSEIMSRILAFEADRRTLNITINSFGTELSKEQRARLFPSIGRLFPEGNNALARADDIDTVVAAVDHIAEYKAFFDKAGVTSGGGAGADEASSSLEDEFFKHDVELNKQSFLQQFQYAVFYSFVKLKEQEVRNLTWIAECIAQDAKDRVNDYIPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0S0</accession>
    <name>A0ABR3C0S0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616446.1">
        <property type="nucleotide sequence ID" value="XM_066756160.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988464"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0254225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="15531" checksum="B2D143FA9C8A649C" modified="2025-10-08" version="1">MPRSSRSSARPSARPSAPSHSSASQSRGAHTAAYPAQHAPAQHAPAPPQTVHVQQQRQPGLLAQAASTMGGAVAGSVVGHGISNMLFGGSGHQAAPAPAAEQAPVNQQQFGASCDIQAKDFTKCLEATNGDMQSCGYYLEALKACQAAARPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0S6</accession>
    <name>A0ABR3C0S6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616403.1">
        <property type="nucleotide sequence ID" value="XM_066756117.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988420"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="199"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="412" mass="45728" checksum="26B7BC036BCD03F9" modified="2025-10-08" version="1">MEIDPPASSSTSPVAYLDAQLASAPEELKPWWTKIKDQYERKLWHNLTVTLTQFVFLPGTGQYQIELFEKFIKTVESKINALKLVEIARRVGREFSEPDLTLKFLQSVHSRLVSPYPKPATDSTPEVPAPPPPAASAFALSLSSIAYAQLLLGDLPACKSSLDECEKLLSEQDTVEPVVNAGYYGVAGDYFKVKADYAPYYKNALLYLACVDVNAELEAEDRKSRAHDLCIAALLGETIYNFGELLQHPILQTLTGTEHEWIKSMISAFNAGEIGKFESLCNNLPNEPILEASLSFLRQKICLMALIQTIFARPRDGSSRLMTFQSIGEATRLPVHEVEHLIMKALSLGLIRGSLDQVGGTADITWVQPRVLEGKQLDILAEQFKAWTESVGKTEKKVEEQAKAAKTQVLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0U6</accession>
    <name>A0ABR3C0U6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-L-rhamnosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616479.1">
        <property type="nucleotide sequence ID" value="XM_066756193.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988497"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF2">
        <property type="entry name" value="B, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="1">
        <location>
            <begin position="49"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="375"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0254258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="792" mass="89881" checksum="15EE1EBCC2BB3846" modified="2025-10-08" version="1">MVTSEEQRTINSLQANWVWVPNWIDSSSDNSAARLASFTRSFSLSSVPTSAILYFSADTRYKLFINGERVAVGPTKGHSSIWYYETLDIAPYLKKGQNDVEFLVIRYFASSRGGMPFERTTFPGLTVVGEVGDVDLTSKEGWQAVVDQSRVYPTGLVDDVFLHINERVSVTSSRATPLTPIPYSLKTLNGELPPWRLRPRSIPLPESSPVTVNCIQACQSPIPPSDWFASFDSSEPLILPAETSHSLDIQAEVHSTAFTKWIFFSEKGSKVEFRLTYSEGYELDPRQYPWLRTKGDRLDSKNGHLLGPYDDVTLQLSPGETVIYEPFWFRTFRLIRLQIEVGDQPIKLISFEAAQVNYPLGVKAEWKEPAMKENEKIWEVSIRTLRNCMFDGYSDCPFYEQLQYSGDSRSVGLFHYLLSGDDRLMRQAITNFAASVTPEGLTQSRFPSHVPQIIAAFSLYWILQISDHYLYFGDTPYTKSFVPKIDGVLAFFDSHIDELGLVSGISEDVWQYCDWVTSWSATEDHPDKGVPYSGRKSNRHTYLSLLYAYVLKQAALLLRQVGRAGNAMEYEERAKAVIEAIKKHCYDGEFFTDSTADIADDLAYSQHCQVFATLAGVITPSQASQLLTKAFSNPKFSKCSYVMIFYALRAFAIAGDETYQHFYKTIWNPWRKMLKNNLTTWEEDDVRQRSDCHAWGSVPVYEFCTEVAGIQPLEPGCRKILFKPRVSLSDELEAKIALGKDNLAVVKWWEEGGKKIVTLVLEKPVMVVVKKPGEKQEENDEPMSSLRLICKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1M7</accession>
    <name>A0ABR3C1M7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NFACT RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616276.1">
        <property type="nucleotide sequence ID" value="XM_066755990.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988292"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="209" mass="24292" checksum="4C42ED37CE63B739" modified="2025-10-08" version="1">MVVFFTSKVVSPPVTIYMGKDKVENEELLRYGLPSDVWFHVDKLSSAHVYLRQPDGQPHGEWDQLPAALVNDLAQLVKANSIEGNKKDNITIIYTPFTNLKKTGDMPVGQVSFHSDKKVKRAHISTRDNVIVNRLNKTKVEREVDHEAERQERLRVEGRKKKTEAIERAKKEQEQRKAWEEEKQARSYDNLYSEDAFAEQEQFSDDEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1U8</accession>
    <name>A0ABR3C1U8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615745.1">
        <property type="nucleotide sequence ID" value="XM_066755459.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987754"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="117"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="167" mass="19112" checksum="CF3B27370C1BBF86" modified="2025-10-08" version="1">MAEKKQTVILTTSDDEQFTVEKIVAERSAMIKSMMEDLGDQEGQPIPLPNVSSSVLTKILEYCDHHKNDPLPTGDANDADDSRRKTSEIGDWDARWIQVDQEMLFEIILAANYLDIKPLLDVGCKTVANMIKGKTPEEIRKLFNITNDFTPEEEEQIRKENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C306</accession>
    <name>A0ABR3C306_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616342.1">
        <property type="nucleotide sequence ID" value="XM_066756056.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988358"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039713">
        <property type="entry name" value="At2g23090-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788">
        <property type="entry name" value="OS07G0114300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788:SF1">
        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12907">
        <property type="entry name" value="zf-met2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="At2g23090-like zinc-binding" evidence="3">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="77" mass="8135" checksum="B9FBB26DFAD14565" modified="2025-10-08" version="1">MGNGAKAQAKRDRNTKAAAGKGDQSQLKSNAAAMTIQCVTCKAVFQGTSKQLVLQQHVDSKHPKSDIKTCFPTFAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3U9</accession>
    <name>A0ABR3C3U9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc finger protein 830</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616580.1">
        <property type="nucleotide sequence ID" value="XM_066754679.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986958"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="31951" checksum="90A4A7D2C993AFC2" modified="2025-10-08" version="1">MDAKSLLRAKKAEARINHPYAVYNASGVLRCSICAVPVKQWDAHLLTKQHRTSVAREKAEREKSERAKRSRPETEVESGSSSKRPKVAQQPQLASREGSYGEDDVPSGLPAGFFSANNRTVPEPKTEALSSPSIAPGAATAAKTGDAELDDFLASLADDSPAPDTSAPAAPPTAISQAQANGGAKRKTTYKQDIIPGQASYEAAPVRIIQTGEEEQEEQKEAPEENEAEKRERLQREEREDIMARLEEEERAQEDADSRVMALKQRMEMLRKKREARSGVMGKGAAKDASQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3Z7</accession>
    <name>A0ABR3C3Z7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616630.1">
        <property type="nucleotide sequence ID" value="XM_066754729.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987011"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF0">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="TREH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trehalase-like N-terminal" evidence="3">
        <location>
            <begin position="31"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="2">
        <location>
            <begin position="323"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="82765" checksum="8586D985DDA30E9F" modified="2025-10-08" version="1">MSLQSPTNENKMVEPTDIPKKSLDKLGLPVRSIQDHALIGNLRTAALVSMDGSIESMCIPYFDSPSVFARIVDADKGGHFSIVPTWPFKPKQAYAPNSNVLVTKFLSERGVGVVTDLLVPRGANLNNSSSRAFLPWLIRKVESIRGTVPFKMECAPAFNYCRDKHTAEIVPDDSSANVTSQDTKVVFKSPSLTLDLRMITWSSDQCVSDPEVKLQLADLSGRGLLGPAATCDFELEEGQCIVFIMREVGDYSYANEKHEEFANPTMSKAKSMGVPVEQMLEATNRLRPKENPILTRSLIEALIRDTTSYWKKWIGGIKYSGRWRQAMLRSALTLKMLVFEETGAIVAAPTFSLPEFIGGQRNWDYRFTWVRDSSFTLYALIRLGFTEEADAFVNFILERLKDRNSDGSLQIVYTIHGGKDLEEIELSHLAGHKGSKPVRIGNGAADHLQLDIYGELLDCIYLAQKYSKPLGWDSWVAVRQVVDYVCSQVDKPDLSIWEVRGKEKNFTYSKIMMWVAIDRGIRLADKRCLPCPNRSKWLETRDRLYEAIQHRAWNPSKQFFAQSYEDLNTLDSSVLIMPLVFFISAADPRFTNTLDAILKTPEKGGLTANNSVYRYNAQLSDDGVGGEEGAFSLCTLWCVEALTRAGVFNAKYLDHAMNMFMDFLGYGNHVELYSEEISAGGEGLGNTPQAFSHVTLISAGFNLDRALSGSGRNNSSVQWWRKALFTEGAVLKIEYLGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4I2</accession>
    <name>A0ABR3C4I2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocation protein SEC72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616812.1">
        <property type="nucleotide sequence ID" value="XM_066754911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987197"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27430" checksum="40FBFC5063492231" modified="2025-10-08" version="1">MAQPQPLPPQGAAPPSIPLSAAQLSLLDSIPHAHIPHTLKTVTIAPNAPPDIANKSFVLVVCKLHDQQKCDQCRVDFTPVNYLHQFLRFAPAEAIPPPPNVAPPPQRAQAVTNLKDAGNNAFKAQKFDIATQFYSKATDAALSRPPWEPAALGREEAAITLCNRSASYAFSGNWTAALADAQTVINLKRPWTKGHFRKARALVGLEQYEEAKQAIIDGLQYEPNDKELNTFLQEIEEKIREADKAFPDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C543</accession>
    <name>A0ABR3C543_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100534</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617004.1">
        <property type="nucleotide sequence ID" value="XM_066755103.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987392"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="103"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="215" mass="23448" checksum="A7296665576FC24B" modified="2025-10-08" version="1">MTTDNPTQPLKTTKQTHPDLPPGLILGPDGKPCKVCNSWQDWAKIKVKKKAASGGDNTEKKNISGSGAAVGMAGFASMLAGAGVSKAQSTNAPLNQTPERSNCPPDTAELGRSTWTFLHTTAAYYPINAPPQTQSNMLNLLSSLSLLYPCSWCATDFQKDMRRHPPDVSGRESLMRWLCERHNEVNEKLGKEKFGCDIKNLDVRWKDGPDDGSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5K0</accession>
    <name>A0ABR3C5K0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617174.1">
        <property type="nucleotide sequence ID" value="XM_066755273.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987566"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="629" mass="70248" checksum="6C3E47ED2825BAEF" modified="2025-10-08" version="1">MMPTLGSSRSFSSLNSILRKRRTGMLSSPSRPWEPQSSDPNFYDDSRSERSPQSSSFSAISSSEDLDQTTKQTLGNTNLLFQHQEGWHSSPSIIESDCEHSSIGNRSVSSLSESIITNNEEEEDHYQATFNFPSDLRFGDDHHNQWLLSLSDASTDSEEEGAVFTANAIKMIPVWRLPAIDVEQEVSVLRPAVQPLISVALSGRSRTWSDPLEDIEEEYEGEREAERKRASMEGSLGTGSISPYLCDGGTSGLWGNLGTRKNSDTALSLSHSEASIGRLKSPSQVTVSSRAKMSRENDMEVNFPLNGAWESKDRQLNLQIDDEDDSVYQPPYTSSANSKFSFSSSRLCRKLNRVFSKDIATSRLRSSKPVTYIRDVLSTCNTALFHRKRATRLTDTEETLSLNLTGNKSQLERRQPEQWNRESDLEYSVSSDQIPEVMGQFTDTLASTEITRAGNMEDDGSLKNGGFGSSSGILHFNVAPKQQIEVKASPSINMTLSPSFLTSTSEQFDFDKHPSTTSFFDEGFRFENFVAAANDPASTSPTVVDPRGWRNDTPRIKTDTDASWLMPGGSGRTFQQAMLDSQAQRDTQLEYLDTRFRRQSHYLKDIMTEDLRSENDFSSDLLSLGHLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5P6</accession>
    <name>A0ABR3C5P6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617220.1">
        <property type="nucleotide sequence ID" value="XM_066755319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987612"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="132" mass="14349" checksum="042B0CE786C47F27" modified="2025-10-08" version="1">MIALRLLTSLASRRPIQVARIGAASFSSSSSFASPKTKSGRTVVSSCPAGTPLTNLSILKDKPDPVALPDDQYPAWLWTLLEDTSKAHKAQENAVHLTQEGESGFNVQAEKRKLKNLNRQNIKATNYLKSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5P7</accession>
    <name>A0ABR3C5P7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UNC-50 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100764</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617230.1">
        <property type="nucleotide sequence ID" value="XM_066755329.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987622"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31794" checksum="6C5236426D0AA387" modified="2025-10-08" version="1">MSSPILPLSGSSYPSSTSGGPRRWDASGGAGFGGSRNVDLGIEMETGLGTGRGGLSTQLKRLTKFRSMDFELAFWQLTYLVVAPRRVYKQTYHHKQTKNQWARDDPAMLILIAGCLGAAGVAWSLVYRLPVLSLITIPLLMILRDFLLSSLVVATILYFLSNRLLLAPSVPYASTSDNRVEFAYAFDVAVNAFFPMFLTVYVGLLPLAVVVVRNNWVCLWVGNTLFLIAQVQYVYITYLGYAALPFVARSQVLLSPLLPIFGGYLLSLLGFNTAKHALELYFRQSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5W9</accession>
    <name>A0ABR3C5W9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617309.1">
        <property type="nucleotide sequence ID" value="XM_066755408.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987702"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="9">
        <location>
            <begin position="72"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0256032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="223" mass="24173" checksum="99F314236F653B7F" modified="2025-10-08" version="1">MFANSLRQGLRTASRTSARAFSTIPARAPRTNVVGALALGTAVAGYALYETARSPVLLEGPRTIAGEKGTVTERSFVMIKPDGVSRQLVGKIVSRFEERGYKLVAIKSLTPSDALAKEHYADLSARPFYPSLVKYITSGTPVVAMVWEGKDVIRQGRRIVGATNPLEADAGSVRGQYAVSVGRNLIHASDAFESATKEIGLWFAPEELSEYEPIAWPWVMADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6F5</accession>
    <name>A0ABR3C6F5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thymidylate synthase</fullName>
            <ecNumber evidence="2">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617193.1">
        <property type="nucleotide sequence ID" value="XM_066755292.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987585"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="317" mass="35907" checksum="D40FE3D0EA1EB204" modified="2025-10-08" version="1">MTATINDQDKIERSNPDHEEYQYLDLIKRIINSGEVRPDRTGTGTVALFAPPSFRFSLANNTLPLLTTKRVFLRGVIAELLWFVSGCTDAKVLSSQGVGIWDGNGNKEFLEKVGLGHRREGDLGPVYGFQWRHFGAEYTDADGNYKGKGVDQLQRVIDTIKNNPTDRRIILSAWNPKDLPLMALPPCHMFCQFYVSLPPADSPNSKPKLSCLMYQRSCDLGLGVPFNIASYALLTHMIALITDTEPHEFILQMGDAHVYRDHVEPLKTQLEREPREFPKLKWARSKEEIGDIDGFKDEDFVVEGYKPWGKIDMKMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6M9</accession>
    <name>A0ABR3C6M9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prolyl endopeptidase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100802</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617268.1">
        <property type="nucleotide sequence ID" value="XM_066755367.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987660"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="9">
        <location>
            <begin position="57"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="578"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="796" mass="87922" checksum="AFD7A9C34F6BABBA" modified="2025-10-08" version="1">MSSQQANHTFSTDQAAHGTLKNVHVSDFAVNPGHWKKQVNSSPYPVPPQHGGVTEIIHGIEIEDPWRALENSDSEFSVPRLTNHPLRKELEAAVEQCYNHERMTNPELQGDGYYYWQFNPRTAPQDVIVRSKNLKRDFGKAPSSDGPEIFYDLNKEENISLYAHSFSPSGKLWCAVLQYGGSDWQRIRVIDTESRTVLEKDLGGSKFTFGVTWVGEKGFIYKRSVDYDATSDDYDGIDGAFGMFYHAVGQHQSADIIVWSPPPGEFQFIGKSKVVTVDEKEDNNRRAFLAFDVYKNTSPETELLMVELPGGTAGPAGAILPELVTKEMKWVSKGFTGETHYIGSSSAERHFFTSFTDCVSTGHIIAFDSADWDVTHIDGTLPMQEIVPADPEGHQLQSAHLIGDRLLALIYLKHACASVYFIDARNGKPLGSADAEGTHGNVAADSETQVPIPEEEVRHSKEGQVDIPEHSAITSISCRSDANDFYFTVDTWVAPSYVLKGELIKNKAGRCEVDISSVNSSEAAAPETLVCSQVFYSSYDGTKVPMFICHPHDLDLTRPHPLLLHAYGGFCNPLIPHFDPMFAVFMRNLRGVVAIAGIRGGGEYGKAWHEAAIGIKRSVGWDDFAAAARYVQSRGLTTPSLTAIYGSSNGGLLVSAATVRNPELYSVVFADVAITDLIRYHKFTLGQMWMTEYGSPEEPETLAILRATSPLHNISRDPAIQYPAMLITTGDHDTRVVPCHSLKLLAELQTRKAKNHGAILGRVYINAGHEQPTKSSEKKVEEAVDRLVFALDNIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C755</accession>
    <name>A0ABR3C755_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616601.1">
        <property type="nucleotide sequence ID" value="XM_066754700.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986980"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="2">
        <location>
            <begin position="66"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="476" mass="52983" checksum="BBAB460C26A6190B" modified="2025-10-08" version="1">MSIRPQGYSLCKDATSSPVPTLSQPPASTRLPAHLPLYHRLLFPHHPLGEPLPQLVNGNGPEIDLLNERIYNLVALALRGYILSWYTRFSKDRSLLPSIHSTIIHPILSPVLTSVYDNPEQIVKWILRDLLCSVEIHVKVYWEAKAALGAGTLGDRYHARLPLPSVTASSSPAPHSPVDPTYTLSSEYLTSLSVALIQPTETEEERSQMGLQGLMIREVLARAILAGGMRRLCFGWFWYGLILKLLDEPGDPFPWRRTTPQKQDEPESLHQVVLSYMRTIITLFTTIYSAIVALIAVYTAAPPPSPEYEGCTDTLMGMMREMVGVDGYAGIEAKKWRKRMVWGGVEMVVGLTSPILDRIIPHLLSSQLTPKLSFRLIDLAEKLLFPLDGYPGPTPIDPTPDEAANMRNKAEKRIGEIIPKPLRVVFCPEDKDVSRLMEWMSDAGCNAHLVGMMLVSLVATLLPDLVDKTNSKDGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C7J8</accession>
    <name>A0ABR3C7J8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616751.1">
        <property type="nucleotide sequence ID" value="XM_066754850.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987136"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="447" mass="50767" checksum="62DB09AFE42BD057" modified="2025-10-08" version="1">MSSIMRLFGKATKHQERDEAWIAVADEEVGVKRNGPKGKNSHQWVEAQAGQKSSKSSKDGDANDLDTQPFVATNPGFSKKKLLLWRLSIVLPFLTAGCLLYLLTCSASSWRANWSSIKIELPSTDFDDLYASGSTITGQSSIGLSSRMDFATYMSAKSIHYKRVNDINDVLGGYLSLNLWGWCLKSTEQAVPIMCSSESMWFSMDDLVDSSSMNTGKLTKDTFNPFLVHALIVHGFAMLFTMLAPIPIVLNTWRILRAQKPKVDTSWFENITVSVASIMCLVSWVVNRCLQANVSSKLPDYDVDAELASMIMGVSSILLAVTFLVSAVPCLYLHMRRQNQLLKYWMNLEDYDEAVARQHSEEAEKGNNKKYDKDNKGRSRSTTRSLPRRGLLDRRLTNMMFGGGYDDRENKKGKGRRREKQPSQRWSRRSRRPNRKNYGHRHRHSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHL0</accession>
    <name>A0ABR3BHL0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610702.1">
        <property type="nucleotide sequence ID" value="XM_066761162.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993595"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="121" mass="12876" checksum="7DF997991CEA44DF" modified="2025-10-08" version="1">MKLNNETVTIELKNGTVVHGTITSVDPQMNTHLKSVKLTLRSQPSSQPPLSLDSIAIRGNNIRYFILPDSLPLDTLLVDDAPKPKKKKEGAAARGARGAARGARGARGGGRGAPRPRGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHR2</accession>
    <name>A0ABR3BHR2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106783</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610742.1">
        <property type="nucleotide sequence ID" value="XM_066761202.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993636"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="1993"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="976"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1426"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1426"/>
            <end position="1445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="2188" mass="241561" checksum="A3CF855E35274A40" modified="2025-10-08" version="1">MPPRTTAQRVALAAPKVPTRVSARSGTQVPTTADELVDGINKLAVSKPEPKVRLTRTKPSSSKAASSISAKAINERPATTNAAKGKEKATFEDSLPWACSTAGETLRPVERAMQAMQATNASIKALGESENSGYRYGSLNVSNEGSEWTDEKVVRLVDTCQVAFRVLRELDEQGMIGDKGAEVERTCQGVVHKAMEVLVEARPALLRLYKAMNVEASKITAIKVSVTSRATSSSRSTVGVASKTATTTSRSTPATSRSTRPTSVAESSKSSLKSEKKASVPSRWLELAWFPAPMEGTEMSEPVKNLLFMAMASAWTGLIATSKGSEEVLAMMPITPVSAKLNPLVLGLTLPLTSITPPLYSLYRAIDTLNLPSTSPLNIRYRQIALSALSMTICSSAHSRNSPTRLWEAAHRAISTYVQVQNSSEDLSEAAQVINKLVDWVESMVEKRGENVKDWLSGKGWLGLMEIWIAVGRRLDDVDIIDKALSLMASSSSISTPPSTTLSTGEPVSWALTGTPEVEVARIRGDLAKASLMFDKIFSGQSLPTPEQQRIDALSLEDLNVLGQAVNTLPNDEESKILIDRVVRAWERVRRGCVKVIDRYGTEESCKVLVGLVERWSRAALDFVENVADRIEINPSLADYLITGIIDTICFLSQRYLSSSSILLPRGYELHRRVKGSTKVVDQIDWLRALSIAASNIGGRLFSQSRMEAAVHLASLSCGWAVEAGKLVKVEEMDEEEGKKVQQLSEGLAKRWEFLASCYQRHGQKKEVFSAYIQCLAYQPPSLLSKLTLAASQPISKIFEPFTDFQNSLLRLFAFILYDPTLCSDFGVSLMKEMTTNSYKPHEVGAIGEKMMDTLEDGAWKEEVARIVLDLGEGLLDVYGTEFPIRRLRVVTRMMRIIVSSGQRMLRFDRLVEDADRLFVQTNLGHDISLGPYKKEHYAYTLILRALRAYHFEGDPTPAVLKNHKQAMEALHEVLIPPTPSQDIKDQPRKKQPLGRTTTTRAVTTRSAPARPTKGGQRTVSEPQRKAAGKAMTSVTAVKEPRLVFDDLKKLTGLLGALASLLALLGQTLAQIETLKLIRAFQRGRDELIDDYIRRSSQLATEYFKLGKVSRAGNVFSQTHRTVLESKVLVDNGIKVELLLRWSCYLAGTGDTVKAREAYIEAQELNSDFESTKSKSHLLHVQVMNRCDTLERAAWSRAAFGAINAAEDNATGAIIHLSAAFRLWTRASDAICRIAEKQPSSNASRLGLEDPFLVMPNPKRLKGADEPAKDEIGPTPPQAAHFSGKHLHNLQWHVAHGLLDVTFDLASAYAARGSVRDAEYFLKVAGLVSETIKSGSMGARVGTREAELLFRLRKLEDVGTKLESAAGLLCTEEGPEVVDLMRVQGDLYTRQGMIQEAGQMFQSTSSEIAGLDSVFVAVEALLPTPKKSSGLNSSNTSGRTAQTLRKSTDSKEPLLPVALAHVMRQHAWVLREAGSKEECTQLLAKIKNLPSTTQTKAEELLLQGRIALHEAIKQFKTDLFMSSLTESAVTMPLGIPEKKIKDRQSTRLSIQAVLTRAEDAFLSALDLVAGGGKVESIRQACLALALLKAFQTSLGQGSQNVTSAAASTLASSSSITLHRELLHAIETKFIDIEHSDVNWPSFDPSDTVKPNNGDVDLSEDLDDHDGKLRSYWQMIKSKYESKHILAADAISLENLPANWAVISINVSEDRNTMFISRHQNGYEPIVFCLPVDRQGRREGDDDIWTFDAAVGELETIIKTSNESARRAKHIISPEGRAEWWAERRALDKRMEELCVNLEFVWLGAFKTILSPRNRFSKADLSNFSDSLDKIFQAALSGGRNSKTKGYATKPHLDDALLESFASLSSKCKEEEIEDLVYFILDIYQFHGVPVALSELDIDQIALDVKSVLEKVEMKQNKISSTLGEEHIFLALDKNVQPFPWESIPILRGRPISRIPSLSFLLDQVAMGNHLRPSLTQSIVAADNHLDIRRIVNSRRTFYILNPSGDLARTETHFKPWIDEMVEKAGWKGIVGRPPTEMEMRAALRDYDLVLYFGHGGAEQYISSQKIRSLPQCATTMLWGCSSGHLKEQGDFDRTGTAWHYMVAGCPSLVGNLWDVTDRDIDRLSEHVLKQGLHLDAAHQPQSRSRANTLLPLSELSTVQAVNKARNECKLKYLNGAAPVVYGLPVYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHT4</accession>
    <name>A0ABR3BHT4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dCMP deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_106809</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610767.1">
        <property type="nucleotide sequence ID" value="XM_066761227.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993662"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="9">
        <location>
            <begin position="201"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0240259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="349" mass="39383" checksum="5507F454C1491818" modified="2025-10-08" version="1">MFIAIIGTPSSGKRTVLQYLEKKYGFKHLRLSKGEVQLAEHMDGVVNGIEKLNTESTATVFANVPDLLDHVTRNWLSHFVTTDLRTYEEIDLFLKRPFFLLVSVDGPLRVRFERERARTEAEGRDMTLEDFVDAHDSLLHGLPSTQIHALPALAQGQFMSDFRRILTLAHVHVDNNFTDISALNWYLDRLDLLDEERLRPGWDTYFMTLASLASERSNCMKRRVGALLVRSKRILSTGYNGTPRGTRNCNQGGCSRCNGSARGGEALNECLCLHAEENALLEAGRERIGDDSVIYCNTCPCLRCSVKIVQCGVREVVYNQSYSMDEASARVLKEGGVTLRQLHLPSEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHY2</accession>
    <name>A0ABR3BHY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610822.1">
        <property type="nucleotide sequence ID" value="XM_066760997.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993428"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.130">
        <property type="entry name" value="Ubiquitin-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="589"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="701"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1070"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1271"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="709"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="776"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="844"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1089"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1183"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1207"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1294"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1319"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1340"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1379"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1415"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1441"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1504"/>
            <end position="1515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1532" mass="169971" checksum="EC876ED29FF92FCB" modified="2025-10-08" version="1">MEQLEVHDDSFAAHHISRTSTPSTSSSSTASSTRAQSGKGKQRAASSEVEEETHAATLEKEVRGSSGGKRMAGQDRQEANGSRARTRISNVVNGYSPYGASQRKGTASGRLSLAKAVPEGEFYSSPKVSGARQLNTPTQQNARASTSNTRSLSRNQLLAKARSTHSAGLHDDSDDAEGSPVRRAYKPDEPEDDVPVLVESPDKGPSSAQPIRRTNGERGPNSNPFKCKRKAADIFGNHRDARHPKPSRAAEHDDEVEYMPSEEAKVTKEMRVAELDMLTKQVTPKFGQRQRRPMNNKEGNQVRTSNHAPTHVLKSPGDSVLLTFNVAWISPNTILRCTRITFDGKELRLACEGGGSSWKIDFKKMINIQLCTSHEHPFLCFEVNPNETDRGPLNNLLNGKKLHHEGMVQLCIRPSKSWQTAQRLDAFLSRLKFQDVDQFHELDPASCKLLSESCNSQILDTRARHEAQRRAKVAEAAEKRIASGASSPIDSWPYGTDDKKEEKEKKPATKGGRGKKKEEQEDRNQSKLNFAPQPVVPVPVRRSSRRSTNKHIEEISSDDERPVHLPKKPPPADKNELYFCYPPTEKAAVSITQGDKFRVEVGEFLNDTLLEFGLRHVLSQVTDARREETHVFNSFFYGKLSNKSKGSKPTPDGWPAYDSVQRWTRNKNVFDKRFIIVPINEHFHWYLAVIINPRGILRPRDPEPAPEISRPTTRATAGSTAGGSPEHSYSELMGDSKLQAGPKPSAGAQADKDASPEKEKETASDHQSAPDPPSAQPNQSPQRSLGQPTTPSISRKSPFFQSSPLTPALEGDGGEFPHPGDQSVDPLDVMSQQTDTERDEDVEMKDVRSGVKDIDLDGPPNSKNEKERSGDEGTGGFIVTPTLLAMQQQQNQVEKGAKLPLVTTVLDDDEGEENAKAKDFASEKKGRARGLDANFEDGRTWIITFDSLGGAHRAVGTNLSRWLQYEAKNKLNVDYEPEDAQYWHGKVPQQGNFYDCGLFVVHYAKQLLQRPKEVLSFVQRRQPPEWSPQAGQWRADLDRFWQASETKNLRISWLSTMDDLASEWEKIEKERPKVADDAEGEGDASQVEEVTKEEREAEARMEEEVEQELKRRQEEIDKGEGEKGEEKREEEGDDTRGESEATENDMKKEQPPDENAEDSEPPLHPDFDPSLDLQLDPEFIRPENTTTSTPAISQTQQMPASTPLEPASSDSSAVSDALAERGTSTVPDVDADINTDTAMEDQQEKVAKINWESPIPNRPAPGIFDREQEIEEAGQEREMDGQVTMLIDDGDPILSSSLPSQTPRAYNSPTHGTHLRFEEENELESEEEKEDETIGVKIHRQQEDKEDRNGEEKDTKNSVRPLARTSRYFAPSNGDSSPHRTKSPFRSSAAKKPRHHGDRASSPIDDGPFAGLSESAPNANSRSRSGSLHEPASIPRKASRATRDEGEDRGDEDHKNGLESGRKNTTSRVPSPKKLAPASTYAPTSAKKAPKRVAGRNDIETRANKRAKGGNKGKGRQSTGASRDEAIELDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIJ7</accession>
    <name>A0ABR3BIJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_106310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611015.1">
        <property type="nucleotide sequence ID" value="XM_066760743.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993165"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0240516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="44912" checksum="11FBF5C804E05A20" modified="2025-10-08" version="1">MAIFNRKKKARLDEEPAPTEKEKVKWSKRPANTAFKQQRLKAWQPILTPKSVLPTLLIIGIIFAPIGALIVWGSGKVTTITLDYTECDADAPTDGSYQAMPSSAYQYDLATSSSESKYSIAAPTWTFSNDSSRAVDETARCEIEFEVPYDLGPGLFLYYKLTNYYQNHRRYSSSFDATQLIGDTRSLSQINGGNCKPITSRDGKPYYPCGLIANSLFNDTFPSVVLLNPTNGAENQTYNFTESGIAWSGIRKNYASTLTYISPSEVLPPPNWALKYPNGYVDGFPNLREDEHFQVWMRVATLPTFRKLWARNDNEIMAKGRYRVVAYMNYPVKQFSGTKSIVISTVSWIGGKQPFLGWAYIAAAILCVVLAIAGLIRHLIKPRKLGDMSLLSWNQPNPNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIN1</accession>
    <name>A0ABR3BIN1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610934.1">
        <property type="nucleotide sequence ID" value="XM_066761109.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993542"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21690" checksum="84DE5CB486B05A55" modified="2025-10-08" version="1">MSSRSYTKSFITFATSLQPSFLPPLAKHSNPTLRHALIVLPSLPLNRLRIFLLVRPDLRLLNICVPPFELTWKDARTDRYDNRKPPCWPVNTCWWWNDSLRVLMNSDEMKEIFGVPSHLTRSFLGLSSFMQAAYHLLPAVIEAGTRIFVYSGMNGTILPYEGSLAWMSRNPSSQFSAFRQPPVTIPPAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIS8</accession>
    <name>A0ABR3BIS8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610979.1">
        <property type="nucleotide sequence ID" value="XM_066760707.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993129"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="475" mass="53781" checksum="3048D3B6DF40FC42" modified="2025-10-08" version="1">MRVTLPNPLGEPITFDSADSPGLAAIPPLALFTRSSSLIGFSRRPHFKIVLFLIGFVFLLTWHPSPPFPPSYDEEWAWEKAAVDEIGVTGRMVQFDIPKGTGFNHQLQRVLLQHHIAVLGNRSLSFEPYYEDQTFLPFNPGRWPWRSARIPLSAFISTVVSGFETLYNSPRAIPSWYYRNQCPASKEKVYTIRSESNPDGDIDLQDDGQARIHQLQVILAGSDEKCVRIIGEPFNNDFFNSKGPLDLYDSFVTSPAMKHFSFSSRVLSILNDHMTTLAPQHEPYDLATAANVKSEGEIKSTMWKHVLALHIRRGEDWERVCEGKGETAAPFVSFNNLPLLPGNENVPPPPDMVPATRIGLYRAKCLPETLDIIARARRMRKNHPLLKSVYILTDANDEWIAKLRMWLESEGWDHVWIGREDVWAGWNNREVGVAVDMEVARRAGVFVGNGFSMTSSNIALLRSRDGIHPDLTQFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIV2</accession>
    <name>A0ABR3BIV2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611121.1">
        <property type="nucleotide sequence ID" value="XM_066760849.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993275"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="196"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="38683" checksum="938D933FC5407189" modified="2025-10-08" version="1">MSVTQLPETMDAIVFKQPYKVAVEQVPTPKLQTEGDVIIKVHLAGLCGSDLHLYRAKEDAGRDYIMGHEVVGTIVQKGKEVDNFSVGNVVAVPFTISCGKCYYCSTSHTSRCISSALFGTPSLPGCQATYVRVPLAASCLLLKPPQLPEELMLLMADILPTGYSAAWNAWRLLDWGEERGGKGERKGICVVVGCGPVGLCAITSAQTLFSKVFAVDPASARRQLAVKHGATALAPGELHSAIMAVTEGRGADAVLEVVGNEGALDTALSIVRPYGAVSSVGVHSGELKIDGGLLYDKNVRLQFGRCSVRHFYPAALKVLVSNQELFMSFIEHKVNFSEAEEYYALFEQGKVSKTVFIPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIW7</accession>
    <name>A0ABR3BIW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610753.1">
        <property type="nucleotide sequence ID" value="XM_066761213.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993648"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0240245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="182" mass="19461" checksum="B52E405334E42384" modified="2025-10-08" version="1">MSFIRPSASTSAFRAVGLGLGRRCLHNSRSLALGASQVKRDALVASNETGGFKYIPGGPILPGTVNDATTFPTPNKAHGSYHWAFERLLSASLIPLTVGAAVSSGTAYPIMDGILAVSLIVHTHIGFDACVVDYVHPRKFPVLGPITRWLLRAATGLSVWGVYEFNTNDIGLTELVRRAWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ21</accession>
    <name>A0ABR3BJ21_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division cycle protein 123</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611179.1">
        <property type="nucleotide sequence ID" value="XM_066760907.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993334"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42407" checksum="0A37CCB03E6E4D02" modified="2025-10-08" version="1">MPVPALLSQVYTLFPTLTREQIDAARTSAWYDTFADITFPAKFIDLKELGEEEEFLRWLESDSIFLPEGSEGIQPPPISTVSDSPPTPRSRSNSNASGSSSSSVAPVYHLPKLNAAVRQAVEQYSGAVFPKLNWTSPKDAAFILPQASSGPLYCSSPADIYLLLKSSDFISHDLDNKRAYSGAQDPQIEENPKIELVLKKFESLNPSREIRCFVRNNMLVGITQRDMNFYDHLQPEEVRNKISRTVRDFWEDEIRGNYEGGDDYVFDLYLSPNFDSVIIIDFQPYRESTDSLLFTYEELLSILQDALSTSDSESRPRLPIFKIIDSQAHPAVTRNAPTYQSNMMPLEMIEFSEGRNMAEFKEAWDEAVRMGMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ64</accession>
    <name>A0ABR3BJ64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_106017</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 13"/>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611227.1">
        <property type="nucleotide sequence ID" value="XM_066760466.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992872"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044976827" description="Protein disulfide-isomerase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="303"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0241845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="492" mass="54230" checksum="F1FE60C6F5E04D51" modified="2025-10-08" version="1">MKFSSKLSLAIAAALPNLVSVLASDVIDLTESTFQKEIAGEDLALVEFFAPWCGHCKNLAPHYEEAATELKEKNIKLAKVDCTVEQGLCGEFGVNGYPTLKVFRNGSPTDYAGTRKADGIVSYMTKQSLPAISEVTPESHDEFIKSDNVVLVAYGDDAHPVPEAFKEYAKGARDSYLFGQYLSSDLPSIPENPSLPAIVLYKDFDEGYAVFPSGEIAHADVDELSEFVKQNSMPLFDEITPENFGSYAEQGIPIAYLFADPNEGSAREKLVEELKPLAKELKGSVNFVYIDAIKFVDHGKSLNLPGDSWPAFVIQDLADQTKFPLTGKATAKTIKDFVKKYVAGEVPPSIKSESIPATQGPVYKLVADDWNNVYGDESKDVFAEFYAPWCGHCQRLAPIWDTLGEKYANNANIIIAQMDATENDIPPSAPFRVQGFPTLKFRPAGSPEFIDYTGDRSLDSLVEFVETHRKSGADIAEEEWEEEDEAPEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ79</accession>
    <name>A0ABR3BJ79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611240.1">
        <property type="nucleotide sequence ID" value="XM_066760479.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992885"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="274"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0241858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="577" mass="61878" checksum="E76D07B680676220" modified="2025-10-08" version="1">MPDSPPDTLSRTSSTTSLSGMGIQFHSANPLPPSLHDKAPLSAVPLLRSYSDDHRQRQQNDETLVSHQTSSAAVPGSAAPGASFSGGNLNLRGRNSNTDSLRIHRNSFSHSFSADRVPTVSTVSTTASFPPAPPSHPASACYPSPAAPRSRPGASPFVDARTARPAHQTSPSAHNTSSFATSSSIGLQMHEARGRVVSPHHPDPSGPSPPEIALDGTSQPSPYDPPHLKANGAWGNENGHASTMYHPLTGKESQYGSTPTVHPAKVPFTESTAYWLCLYFFFNLGLTLFNKFVLVSFPFPYTLTGLHALSGCAGCYIALERGAFTPARLTQKENIILAAFSVLYTINIAVSNISLQLVTVPFHQVVRASTPLFTIFISTIFLRSRFSVMKLISLLPVVAGVGFATYGDYYFTTWGLILTLLGTFLAALKTVVTNLIQTGGGGRLKLHPLDLLMRMSPLAFIQCVIYGWYTGELERVRAYGATQMTSTKAVALLVNGVIACGLNIVSFTANKKAGALTMTVSANCKQVLTIALAVVLFNLHITPTNGIGILLTLIGGGWYGYVEYQEKNRKTKVLDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJB0</accession>
    <name>A0ABR3BJB0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611270.1">
        <property type="nucleotide sequence ID" value="XM_066760509.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992917"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0241888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="362" mass="41903" checksum="AFA2BB49C6609C73" modified="2025-10-08" version="1">MPSELLHLPPLYAIVGLYRLATDHSIRTPVLDKVKHAAVRGIVVGGVYTALSWKAMDWFIQKFLIGGGCGTWQVLTKFECCFLDTRHPPAHSFAPAELNPTRKPVEFWSQGYIEEWAQPPRVQAGELDKNGRRVRKNVSWISWILWWPTQLVMRKYLLLPLSPSLPLLSPLVTSVLRSLTTAEYLHQPYFEMKGMSNDEIWRWVEERKWAYRAFGFATSLLESVPIIGLFFSISNRIGAAMWAFDLEKRQHLFANNIIRPLQPDQVGFYGMGRVDDLGVDIQKAEDELEKKWSQKKRPEDEAISLNFMERVSARRRRARKPFCNITYVGYQMTQHITLVSPTYYIICPPEYLLRRPLAYGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJL7</accession>
    <name>A0ABR3BJL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611309.1">
        <property type="nucleotide sequence ID" value="XM_066760548.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992956"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="6">
        <location>
            <begin position="1417"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="914"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1185"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1320"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1444"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1055"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="630"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="914"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1194"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1214"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1320"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1341"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1359"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0241927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1798" mass="197112" checksum="0C81F753D6007DAC" modified="2025-10-08" version="1">MDSPRHNLHGLPPAYLVHLKALLHQWLTQQTTPTGDSKLWSEERVAQVERAVWEGAVLTSAERGSRREKGILEQNWEGWISGSTKRKSLWRKETRQEEDKSKEDERTEAYTSRKSSTGDGDRGRLSLLITPAGSAVSTPSKASTRASSVVSTERRQNTDSAPQDANREKTPEQSDQENLQEWCRLISTLDGYEPLSLGKADDWEDVDIDRVPKSIHQHIPGSFPQSGLSVEYRHSLDNPSQFKGTFSTLGLPSSQPKHDPSGQSYDILKPVFCLHFPASHSSSTNAKGHALKEDSQSTIRIRRNPSLSARSASSAGSSRWWGSGSKWGDMLGHPVPQDEGERVEVDFVHGRFSLPSDLFGSPALERRGSKKGRVIQRKRRRSIFSALEVISSSLSTNISLPSESISDTTSETNSGLSETDADDEPSERDIKRRIPSRRHRPLSLILSGAEDDIPRSAAEEGKVRLVGGTIVVKGLRDGERKALGEVLKALIWTIGMMKLELDLYTSFRLPHEPDPPIIPFLGTPSSDALALPSLPPQASSNTTPRPSGEDSRSSLSRDKDRSWGRERREGKKGFLSRLGRDTKGMWSGLLSRKGSARDEARGQSGLEGEAYTSPTLSPTLPSESPPSLPLFPTQPLSPHLHSSPPSASSSSFPKFKYSSFPKEPSPDSNSSLHTKPNIHANANANANANANASANTNANPPSQHLQTLSSLLPSSTPGLKYPMPPILLRIQEEERIRWEKTRKEALPVSESDNENGNASGNTLRGRAMAYRPGGDVRSGLHVLAVGMDTLAGWTRLQLLCVLYCVGLPPALSGSKSGSIASEGRQLGEDGKVEVDEGKSGEGEICEPPQPQFIPPTLTIGDYLQNLGEELGENLLCTRSGCEKEVGQHVRWYVHAGVKVGVRIEDVNVKKDVDRDSDENEVLEGEGEGGVAKKAEDGENVEGWVKCAVCREESEPRQLREGALAYPWSKLLELLIYTPYLQPPICSHHTTPHAYITLFRTSSFTASLSSWPVKLYDIRLPKLQIGPNVPKRKVGNGRQGMELMMDGQKEGENSLKREVERWCEALEDRLNVLREKIEREYEATKELSKESEKSGPGLQEKFDTLLSLSTDFTAFKDNSLQSISSTPQSLLNDLQTMKEMIPEYAKEGGKVHALPGSGVLVREDEPASVVAYTLSSLAYFIELTNTSKPADDSNPATATATPRDPTDPSLPTPPTTVTGTPTSASTPSGSGWSTKIEHRDSPRDLLSLRSIVRKKSDASVSLDRTKLAPPALGLSTLSGGAPSLELNLEKVEGVSEGLESGDRMEEIVKAVGKATGQEMTLGTATAFSDPSSLSRRASMTESDSSSLSGIRLSPQGTKNSSQGPPSSFRPFRSVSSIAVSRSPMSPVSTATVSTASNPTTASTLSPNTASIPGARDSSRDSVRFSFASSVNSLWKLGSEMSETFSSMRSRPRDRPLQSLMGPMSSMDNSLSTPSSRPHLHFTYAFADKLRLSCTVYFATAFDSLRRRCAIDKVLVQSLERTEIWDAQGGKSKAGFWMTEDKRFIVKEMLNKWTVSDMHALLEISPAYFHYMTGTHNRATALAKIVGFYTVTIKNSQSGHKRQLDLLVMENLFHNQSISKTFDLKGIEGRRILKTKDGDKEVKTAATLFDADWLEAMQKGLVLLQPHAKRILLDAISLDTRFLSSQSIMDYSLLLGVDTRSSFLPFADNSEDKVEQKRENGLLIVGLVDAIGSFNLFKTIESRGKMVMNRGGDVTIIPPDQYRERFENAIRHYFVACPDKWSKVSRKVGGLTGCEVSSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJL9</accession>
    <name>A0ABR3BJL9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611374.1">
        <property type="nucleotide sequence ID" value="XM_066760613.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993021"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0241992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="204" mass="23149" checksum="23E1392E6373E512" modified="2025-10-08" version="1">MSPRPTRAYTLTPLPTSQRLLRTLLTNRHAATIFAQHFKVTPEELVIFRDRSEAVIAGKAEYLQDVRFPQKALLQPERKGEGEGGEEEEAAYLPPKSAWMLNPLGMSRRLLDTLGDEAEAKRVFGEYFEIDQIEELGQEERDEVKVWYDGEGGVIGCRGEGVGRLAILKKLMSHEPLLPFGLLCFGHSDQHRTFTFLHTELEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJM8</accession>
    <name>A0ABR3BJM8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_106158</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611366.1">
        <property type="nucleotide sequence ID" value="XM_066760605.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993013"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="18"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="122"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="222"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0241984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="319" mass="34613" checksum="2ACAAC5964BB4079" modified="2025-10-08" version="1">MSKVKESTVKKPTDTDVSGFLTNFLMGGVSAAISKTAAAPIERVKLLIQNQDEMIKQGRLSTPYKGVINTFARTYRDEGLVSLWRGNTANVIRYFPTQALNFAFKDYFKTLFGFKRSEGYWKWFAGNIASGAAAGASSLLFVYSLDYARTRLANDNKSAGKGGTRQFKGLLDVYKKTLASDGIVGLYRGFVPSVAGIIVYRGLYFGLYDSAKPVVLVGPLEGNFIASFLLGWTVTTAAGFVSYPLDTIRRRMMMTSGGTVHYKSMFDAASQIIAKEGSRSLFKGAGANILRGVASAGVLSLYDKAQELMFGKVYSSGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJU9</accession>
    <name>A0ABR3BJU9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611083.1">
        <property type="nucleotide sequence ID" value="XM_066760811.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993237"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045634152" evidence="1">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="170" mass="15510" checksum="A6250C76D3C45764" modified="2025-10-08" version="1">MKVVALFAVLPVLAVLAEPAAFPEPTPAAPALQIGKPAVGRAANVEARQVVSSLTSAAGSAIGSIVNTVTGGAGSVASDATSAGGVATSGAGSVVSGGISGASSVASHATSGASSVASRATTGTQSATSAASSVAGTSAATPAAIVGQAGLWTAVMGGIGLVVGAAAIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK24</accession>
    <name>A0ABR3BK24_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611474.1">
        <property type="nucleotide sequence ID" value="XM_066760170.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992575"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="29984" checksum="32188866C0ABCDD9" modified="2025-10-08" version="1">MKLEGKAFIVTGGCGSIGGTTAKHIIAKGGIALIFDVLPEDAGQAKVKEYHPERAFYFKADITNVEVFSACIDAALKVIPKGSLFGGVHCAAIAPGRPWDHKLKNSLAHFQKVMHVNSYGTFLVDACIADAINSQYPDEGPFGARVKEERGCIVNIASVVAKPVPARCLTYGVSKATVLGITSGIADFLGPYGIRVNSVSPAVVASALMGPDRIPYFQSELEAATIYPRRLSQPDEVAQGIVYLLENSMMNDFDLRVDGGWRGSSNWGGPNDPRSNAPSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKD9</accession>
    <name>A0ABR3BKD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610740.1">
        <property type="nucleotide sequence ID" value="XM_066761200.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993634"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="6">
        <location>
            <begin position="296"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="673" mass="73751" checksum="8D4D9898FEB4CD52" modified="2025-10-08" version="1">MDEETDLALLDQHLLKTNQLGQRMTNILGQLDNRLYRLDKAIVPLGIQPLTRKDANIDALLSYLSGKPVASIPDSRPAISRQATTSSATIGYSVEPASTIPSHMTTSTSSKPPSHSTTPTDDVVLLARGPDIMALGEFFSALDKVIDDLEMMYKGLMEGRGGAREAGVKDLTHLVETGFRSMTQLFLKLSKEGMGETFNVDTLLNNGPPTPSNLFPPLNTLLPLTTKMTIYLNPANPTPKTLSIIQPIFEDAISQFATLRGDWMCRSMNALLIKVEAADEGGIWESQGGRGKVGNIMNTWEAIMHAAEGETILAEALFPNHPPQSILTQTLASPLTLANKALSPTLSTLKKYLSRHTFTALDLYASVSRLLPQWDHIMSSCLARLGTPQSPATTELVTALDQPVNTLRSLSLRSFPEKLADVRSAKTEGPPTSAISDVTYSTISYLESLMEYEKVVEGLLGKSKSERSWLMGLNELPSSVRSADEEGGIVKFFVADVLGTLLNHLHAKAKGMKRPIGQAFLLNNASHIRNMLIIRSNSDITGPGAEALLNKAVRDARTQFVSEFQSLTSLLISASHSHSQRFAVPQLPTSERHNLKESSTAFFERLGELEGVVMRYPLNRQDPEMRDSVGKEVEGLVRKGYEAFAARCQSKGAEKYVRSSPDEVSRRVQSMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKG2</accession>
    <name>A0ABR3BKG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dipeptidyl aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_106361</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611064.1">
        <property type="nucleotide sequence ID" value="XM_066760792.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993216"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="16">
        <location>
            <begin position="161"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="15">
        <location>
            <begin position="645"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0240565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="854" mass="95558" checksum="ADCB0CF12CC5F948" modified="2025-10-08" version="1">MPPHSPRSSTSTVYRDTLDIDPFHEKSPPLGDDPRYADDDGQGYAVPRSRKILALLVAIISFAGVVGVLAASGYSVPSFSSKGGTRHITMDHVFNGTFNAYGKQIDWVKQADDGTFSHVDKQGNIVLNTVRNMTTDTLLVNASLVLDLAGNQLRWTGWALSADMQYVLFKTDHLKQWRHSSFGNYWIHRRHDSFTFPVVPPTSPPAVAKCTWSPVGHALAFVSKNDVYIISEHDLSSVSPSSSSAPPHVRVTTDGSHTVFNGVPDWVYEEEVFETDTALWWSPDATRIAFLRSDESKVHDFKLQYYNPSDDAFRVYQYQTELDMKYPKPGTPNPTVTVHTFSLSSLSSPNVQRLTWPGEFPLPDRIITEVGWVADDALLVKEIDRAARDGNVVLFQFESEEGKSKTMEGKIVRRLGKDGEEGDDGWIDHGQNVIPVKGSVPGYLDIVPNQGYNHIALFTPLNASKPLWITAGEWEVTEISGLDSEKGLVYFTAATPSIDRHIYSIPLSFSPNDNNDNNEGGGGMTALTDTTVPGYFQASFSPKAGYYVLGYKGPKVPWQRLIETGAGEDRANVLLEGNAELNKTISEFLKPLVTRTTIENDGYQLNMLEILPPNIDITGRKKYPVLVRVYGGPGSQMVSNRFERDWHSYLAASQRYIIVMLDGRGTGFKGRNLRNPVRDDLGRWEVQDQIAAAREMAKRAYVDRSRIGIWGWSYGGYMTCKTIEAASGIFTLGMAVAPVTDWLYYDSIYTERYMSTPSANKDGYTTSAVNNVTSFSGDKVDFIWAHGSGDDNVHYVNSAALLDKLTQEQVRGWRFRMFTDSNHSMDKRMAYREVYEWMNDYLEEKWGKGGTVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKT3</accession>
    <name>A0ABR3BKT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611777.1">
        <property type="nucleotide sequence ID" value="XM_066759831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992231"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF2">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="154"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="50800" checksum="AA7F2372014C22EC" modified="2025-10-08" version="1">MTAVDSNQGTGKLSGRVGIIGTGHRGRLYTAAVASRASTTLVALCDTNDARMDWHNKILREAGRPEAKKYAAEDFHKMLEQEKLDVLVVTTIDYTHDMYIIPALRAGIKVLSEKPMTTNVEKCKAILNAVNESKGSLTVLFNYRYNPIHWKVAEVIAKGEIGEVKSIHFEWLLDTVHGADYFRRWHRYKDRSGGLMVHKSSHHFDLVNFWIQSVPQSVFGMGSLAFYGKENGQKSGWARNYERARNAKEAENDPFAIHLEDEEGLKGLYFDAEHIDGYHRDMNVFADDITIEDDMSVLVHYESGVNMTYHLTAYSPWEGYRVMFNGTHGRLELEVVENAFRLPIPKGSKSASEHVHGDNALPNEGHSKITLHKLWQQPVNVPYQEAKGGHGGGDEAMLDEIFGPKKGEEERKCPVNGLSADQRDGALAMAVGLAANESFKSGKLVSIKELLGGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKV6</accession>
    <name>A0ABR3BKV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611428.1">
        <property type="nucleotide sequence ID" value="XM_066760667.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993089"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="844"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1549"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1662"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="881"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1524"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1666"/>
            <end position="1677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1791" mass="192244" checksum="7987B31FE7959B28" modified="2025-10-08" version="1">MSHEAGQPGAMGPTSIPRSVSVSDTIAMFERNSRPSSTSMSRSSSRSAIPTRIVSSPSGSGNTVRAPSESPRKHLARSSSYTAVTLGDERPQLAEGNVLNKSRRMSVADGAGEMNGIGVRGVPTIRPQRSASRPLVPRRVTSNTSAKTSPSRTPSASPRNHPGRLTSNESSSSSRAPSAKGSAPDKPTGIGIGVPSTIRNRDVRRASDTASIRPHSPRTSYIIPTRQPFPHSISAPRSLSSQSYGVEHDDFSPRSERSQSPFHLQPTISVSQATPEKPLPSLCKRPSRSNLSERTNGIPIPLSRHASISSIPSAYYTPSSSKSPMLSELERRGEAIDKNLTLDGYFRNVFGKDTLHGLEPIRLETGLEQTRSDPPIAPDMDRGSSDMEMYRRKGTSRSTPPQTTSIPLPPLGEPLGDPITIVSPQQILSGPASQHRSSSTSSLNAGTQAPGPEMRQPSCTTTSTESQPSQPGPARKSPRKPPPSNLGISSPNTTSLLSTPNPSGLATPAATPPIPLKSPLRSISGGSSVTSYNSYSPVEIPGENPIETGIGLGIQAMVKPEVGKIEKEKSVEELASMDSVIPNAGRPLTGQTRVPDLASTTADDHTSHRNDLSAQKEPDDIRLTMLTVPSIYSQDSAPSSATSSSELVDSPAESTSTAGKAGSGDASESTRGSGRRRPMSGVFTQMAVGWGRMKEEMEKRKSIDLGISGHRRSSSLPRPKIILPDERFLASGIMTESPGTAHTNSSAITVASSNFSTRPAMGHTPLSSVPPSSSVAGLRDRSHAKSPSLPILRHYPSSPGSTDPASKGNPIPPPSPRRAETSSALSSFLTPSSTISTATSGVSKRSHLLREIATSERAYARDLKLVRDAYMGPHLQQFREGSLSSVSSSASVSTTGSDKSKRRSMYTFHTQSLSISQTPSVKGEGLPKSPSEGMNLALQSAPSSRGTMSPPVGKPLSPADIKVVFLNLDQLAAVAEELATKFEEAVGEEEEEGRDGEGGSDRMGQVFVSMVPKLQPLYSYFCARQSTASRHLQTLQSHPAHFTYLSQQWSSISSQTRAWNLDSMLIKPVQRITKYPLLFEDLLKMTTPVHADYFKIREAKEMARGMAMEIDEGKRRKEAVENAIGTKKKKVLTAQPGMKDPKSIVSMTQGSKLLGLKRFRKDKDKPKTPPSSSISDLVSPPQIPQSSLNQLSDLSARLFALEEGVTKIGQEIMLWTAAAKETLVAQDELVKTWLHVVQLEPTDPTDQRLLEMRRVVDSIVSEGWGELSIEVKDQIIPILSNLLNSITNPRKVLSKRSAKHPDYTRYHAFRVSKRTPERETVRGALEFVALHEQLIEELPAVLEGCLRILDIAVVGFARAQANYFRTTRDRLRAFVEGWIQSPLGLGAGADLAAGGSNGENSGVMRGADMVKAWQECWEPFAQVMDNFECTKPSFKPAKLNHKDSIYRDDDLHPPGLRHSASTTSAFSPPSSRPETPAFSIPTRIRSSSLRDSFSTAPMIITPHTSSSTFTSCSSQAAAVAGKDSQGGAGGGGGTGIGAGRFNLLRRSSSKHNANTNAPSSHSRPPSRPTHSRRGSGLRPASFTSDSSRKSWGLPQIPAAGDGKMFDGLGFSPTDSFSLTSMAAERSPYLGTSTEFGGLRSSSPSPYSFHAAFAGRVPMPKHPFAVSPGPGSPDTPGSETCSRSGSRADVRRMKAGESDVAEGWRNEKVIYQCACVADFEPIELGNKKYRGLWFLPMVAGDLIDVFHEVGRIDELPSFPYPKVGVDNDGILVGRAENGEIGLVICSFLEPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL79</accession>
    <name>A0ABR3BL79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611575.1">
        <property type="nucleotide sequence ID" value="XM_066760271.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992677"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="737"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0242193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="952" mass="104371" checksum="B064447E91E68E09" modified="2025-10-08" version="1">MASVGHSPYTSKPSPLAGAASQTPTTPSNFSHASPSPIVPSFPISQPPAPMKRPLPPESHGPAGGPPERKFSIESPQGDHGSQQGQKKKRVSLSCAQCAKRKQKCNREFPCQHCVARKVPELCVPYNPQANNNTHGPDPQTSARLESIEAVLSVVVRHTGGIKHYDAIRDWISSPPFQKHLQSAPSTPASPHILMNHGSAPGPSRAGFTYHLEPQEAVQLERGGSSDDDNLAKVGKGWLGEIEGGLPENMELNEKVKMKLDIHGTPAENLQRLITDCGVSPHKIAELVQELPPKPFADRIIDWFFAKLNFIRYPIDERLFRASYEDLYNKSTALDPSNVRALPLVFIVLALAVRQAPEKWAGNEQTRRLSSLRMYWSSRRSILIATAVQSESLELVVSRLLSAMYLVLIHDRRLTECWSQLGASLRTAQAIGLHRDGSKLGLDPFQTEYRRRLWSYLYHADKQYSLVLGRPPSISDSYTDTQAPSNIDLAEYNPALGLPPAKPFHEPTPALFLILRKKLAVVIGKIVHHFQKLNEPAQYSDVEKLQQELDLFVEQLPPHFRMHDPDKSLDNVHFWLPVHRFMLLTEVLVTTIILHRPWLLRKLSSNRYAASRTACFEAAKLDFQIRQDFQRVPDFKLFTITGQFRMFNSAMIAGISAIIDPRGPDSDQMRKILTTFLEDNPWHEVATKDATTRKEVQIIQTLSRRAAKIFEDSFGPGEPAAHDKDSAALLLALRQSNDSSTQTNTYPKGVQPEDAPTPEGPSLMQHKMMLPPRTWGPPSGVTFAPVHHGGINQSPASSCSHEDDHSQKLLDHWINANTSLAVGGPSSGGPLPVLDASGMGYLPLPAMSGAMTPMGLPGGPSLTPNPAFAGYGGQPIMEESGNNFMGHHSTGEFTYPNQFGMLAVEGTGAGVGSGRAGLDSGVENSDEYWNTLIDGILGTTGGMSGPSHTGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLD8</accession>
    <name>A0ABR3BLD8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611070.1">
        <property type="nucleotide sequence ID" value="XM_066760798.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993223"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="260" mass="28373" checksum="2EE4E30AC95EBE60" modified="2025-10-08" version="1">MSRLAPFRPLASLCSAGPSRISQIPARKFGFSPSSVPGLSGFSDEAANPVIRDSLVPIVVEQTARGERSYDIYSRLLRERVVFLGPVNSQDSTLLTAQLLFLEAEDPKRPIKLYINSPGGVVTSGLAIYDTMQYISPPVHTFCMGQAASMGSLLLAGGEKGHRYALKNSSVMIHQPSGGAQGQASDIALHAKEILRIRAALTDIYAEHCTRPGEERTAALDRFEKALERDYFMTSEEAIDFGIVDKIVTQRGKEVSEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLQ8</accession>
    <name>A0ABR3BLQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105526</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611926.1">
        <property type="nucleotide sequence ID" value="XM_066759980.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992381"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="291"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0243559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="648" mass="72736" checksum="69AB97BD64E1BE86" modified="2025-10-08" version="1">MRFGVVSSDSESDSDILSVDYSFSSDEETVDGFQWISTNANPSLGRDIRNALDSSDEEVFDSEDEVEILGLSGKCASGGKNAGKARALSPWNAFSIPQSSKNKGKSAISSSLWRHSPLARSLSGRKVSSSKATLEEVLKEEPDVFETWVKKTEEDAWRDGQYRAAKQQSHVRSIATDARAKIVSIQESQLLQEAEEIRQLLEGLALRHDKQEEELRKAFKEREESLWKDIDEVIRSVEKREAEAAAKAARAAQAEAMKRQEEEDARIAERDRVAREQKAEIERRAKELALKEQQATAVKEAEERRLEEEKRAKEEKEKASKRITDKRGEAGATWNAYTEKQSYMKSEVIEKVKGDRPTMTNLNKGKRMIIRWLGQALNTRESVVKITTDIHDLLIQQLPSLPSPSSPIQFTPDIPKAYAYLLSHVSKVLITQAQSEITSKPTSAFPLAKVVVGLMLRGHAALGDILFARLVKKCPWVVPFYPAPQADQNREDYEKSTGRGADESQHEYISRMSSICTLYFAILQTPLTPLIPTLPSAPTPEELDKLVPKPMRLTYAWTWLALALRDPMPASPPIATLLTTWIEIALAEVIRIYGKVQTDKLRECLEREGIQGVKIKGDGGMSRDKLAFVLDKWRSGGDLAMKGRDWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM11</accession>
    <name>A0ABR3BM11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_105097</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612202.1">
        <property type="nucleotide sequence ID" value="XM_066759555.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991953"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="84"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="398"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0243835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="557" mass="62965" checksum="B369CA19CDB5AB5F" modified="2025-10-08" version="1">MIAPTTSQSELHLLCVSAVVRDLISTYNSSSSSATQPPNVNSLRAKYAKKYGLKAVPRLTDVLAAVPEEWKDRLRGWLRAKPVRTASGVAVVAVMCKPHRCPHVAMTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPYEQARGRVNQLRDLGHSVDKVEIIIMGGTFMSMPEDYRHKFIAGLHNALSGHTGDDVDEAVKFSEQSKIKCVGITIETRPDYCLKPHLSQMLRYGCTRLEIGVQSVYEDVARDTNRGHTVRAVSESFHMSKDAGYKIVAHMMPDLPNCGTERDIWQFQEFFENPAFRSDGLKLYPTLVIRGTGLYELWRTGKYKNYPPNALVDIVARIMALVPPWTRVYRVQRDIPMPLVSSGVENGNLRELALARMKDFGAECRDVRYREVGLHEIHHRVRPQDIELIRRDYAANGGWETFLSYEDPQSDILVGLLRLRKCSEEGTFRKELVGMEGGCSLVRELHVYGTAAPVHSRDPKKFQHQGIGTLLMEEAERIAREEHGSGRIAVISGVGTRDYYRRLGYFLDGPYMVKDLLYDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMT5</accession>
    <name>A0ABR3BMT5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell division control protein 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104511</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612472.1">
        <property type="nucleotide sequence ID" value="XM_066758985.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991367"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="193" mass="21380" checksum="B36903033409D004" modified="2025-10-08" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVSVTIGDDPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEIAHHCPGVPALIVGTQVDLRDDPAQMEKLGRQRMKPITPEMGERLARELGAVKYVECSALTQRGLKNVFDEAIVAALEPPMATKKKSKKCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN01</accession>
    <name>A0ABR3BN01_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104574</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612532.1">
        <property type="nucleotide sequence ID" value="XM_066759045.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991430"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045870554" description="WSC domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="56"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="503"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="619"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="725"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="829" mass="82990" checksum="E7571A4E35FEDB1E" modified="2025-10-08" version="1">MSSFIPLLLLASFAKGAALPNGRYNHGVQKQIARSPNSDDIYLTQAQNGVSGLASGWSAAGCYDDDSWDRTLNKAYGWSLIMNYDSCTNFCDSLGYAYAGIESSFQCFCSNSTNSGASLQPYSKCDNLCLGNWWQDCGGSNYINVFHKTSSSGKKVSSAVSAQAIPSATGVNTRTTPTSSVSSTTKSSASSSASSTSAAKSSTSSAASSSLASSSSASPSPSSSAAKTIYTSSSSSAVSSSPSSAAKTSTTSIAPSSTSSSMISSTNSSSTAVSSSRASNVSTISSAVSSSPSAVSSTSFSSSVASFSSSSSVSSAMTSSTSSVAFSGSSSVTSSSSNLSNVIPTSTSVSSDSAAFSTGSATVTSSVSGFEITSSTSATLSLSSSNSEAAFITDSSSNPECTSSSADVDTSVASAFTYDATGVTSTAPAETVVATVSFVVSATESASSIASSIVSETETEATPITSSAADIATSIGICISSTEESTTSSTAVAASTAVSMPSGWSVSTCIAEGSTGRALTGTSTSSSDMTEAKCAAFCAAFGYTLAGIEYSSECYCGSILSNGASLTQTSSACTMPCSGDSSSICGGPSALTLVVSDTAASTLNSDLTSKPVSLPSGWSVASSPCIAEEGTTGRALPSLTYASDDMPIETCVSFCDNAGWQYAGVSYGRECYCADALFNGASLDKPSSACTMPCAADNSATCGGGNAVQLYVNPSLAQDLTIIDNYYHQGCVKEVTGRLLATNSLAYSGMTLEMCIGFCANQGLPLAGVEYGTECYCSTGSLNNADSLTLSIQCNMPCGGDSSENCGGPDAIQLYVSESFSLGWNNVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN05</accession>
    <name>A0ABR3BN05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105073</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612178.1">
        <property type="nucleotide sequence ID" value="XM_066759531.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991929"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0243811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="454" mass="51794" checksum="6C180DA69F18A6AE" modified="2025-10-08" version="1">MPLYALRLVIDHKTFRLPSLLSISQVFGFPIRFVSEDKTRGLLVIELEKDDDMEKILDRETLVLSAAEVYAEGATYDELHAQLKSKLHVFDSYKHSSFKVIIESAHHSIPEPRQIETINSFKYTGLEGKIRLKNPEVEFIVYEDYDWVPANTPEQRLARDGKFHRVYFGRKIGNGRARHLIISHSVKTRAYYGNTSMEAQMGFLMANQALPAPGKLIYDPFVGTGSMLYAVAQFGAYVMGSDIDGRQIRGKKKGKGIKPGILRAAEQYGLQNKFLDFYPPYGVRAGAKRLGRKEGKKPLREEPYQLPDGTYSHERSDYIPPSRPYELANLTLDLILLARWILVPKGRLVFFLPTVNEDYDEIDIPKVEGMRELKFGDGSVQDFGKWGRRLITMEKIALDDGEPPKFEDHEEFKEGAEDLPGHFGFYKRYLSGFKPKSDSTSPDPSTPLDWQRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN11</accession>
    <name>A0ABR3BN11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612524.1">
        <property type="nucleotide sequence ID" value="XM_066759037.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991421"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF134">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="7">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0245440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="382" mass="41351" checksum="E020872539024AD4" modified="2025-10-08" version="1">MTNPLLAQIQDSFFPPCRVGINGFGRIGRAAFRASLERDDLIVVAINHTAPSIDYLLHAIKYDSTHGTSRHADDLSIKDGALYYKDRRIELFSQRDPLLLDWKSAGVEYVVESTGKMTTVATAGAHIKSGARKVVISAPSKDAKTIVVGVNRKEYNSSMSVVSNASCTTNCLAPLAKVLNRAFGIEFGMMTTVHASTSSQPILDGYSKKNRRLGRGVGSNIIPTTTGAATAVQLVLPELAGKFTGVSVRVPVNNVSMVDLTVRLNKPVASKEELFRPIREASTGLSSLGPLANVLCVNDDELVSSDFLGWQHSCIVDSAASVMLNDRVFKIIAWYDNEYGYACRLLDLVRFIHEYDNGKVPTPTASGVQTPSGAQTPVLRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNN5</accession>
    <name>A0ABR3BNN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612762.1">
        <property type="nucleotide sequence ID" value="XM_066759275.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991668"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF18">
        <property type="entry name" value="PEPTIDASE M48 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="9">
        <location>
            <begin position="233"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="454" mass="51856" checksum="1DC5A3079DBC86D6" modified="2025-10-08" version="1">MPILKPFIPLRRPLCRAHPSVIPTQARYAPSSLNPLFNKSLSRSFNSTNRRQDVLFVAMPALKSGLLNITRFSLLFLPFAIRYKLWKRYRRMSLLLLQIPIFAVCIILALGLDQSPRTGRWRLLLMSEHEELAWSRRKQREILNTDGHKLLPPDDPRSRQVARVTTRLITALEEGDRHIVYGANWPPKSQELSRLISEREALIGGEDRYYPPSGTAKSTYVPYRPPTRNPLKQFESPDWRLYVIDSPEVNAFALPSRDIFVYTGLLDTLPGDDIMLSAILAHEIAHVVERHTVENLGFLNLATVGFDVLRGLAFAFTISFPFITDSAGMCINWINNVLADRAYSRKLEMEADAVGLQIMATAGYDPRAACDLWELMACVEDDAVAMGQGISVENRFTLLRTHPTSEVRQEALSKNMEGALKIWRDHRRKRQPKRVEKKQEKEDIVPESDKLVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNN8</accession>
    <name>A0ABR3BNN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104804</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612754.1">
        <property type="nucleotide sequence ID" value="XM_066759267.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991660"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047443709" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="27"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0245670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="761" mass="84398" checksum="A13C06930235E99A" modified="2025-10-08" version="1">MRIPLFILTFLFTLFSLATTPASADSGVLYTDAVTYCAEAKAVIVDEFDITYHRSNGSVTFSFSLASVESNLNTSINLYINAYGIQIINQTLELCSLLEGVICPLPQVNFTGYGTYPIPTEYTSKIPSIAFTVPNLEAYARVQLIRVENNEVAACLQATLSNGKTARQTAVIWATAMFTLAAFLVAIWHTASGTSTSPIQYRWFDILFIFQIAAASGLLHLNYPLVYTNFVQNFHWALGLFYSPNMQSSINKMREKTGGSMDSTAYSDVQYINRKLSPYNVYMSTDDIFSSQDSFTSFLKENALTKKSLAHLAKRANIPSVLAQNVTTDINTGLPVYANTLRIPEANAYDTVWFVFLALIGIFVAFHVLLFGVVFLFDRMGRSKSRLGWATRLRRMWWPFCIGNSLRLCLIGFCPIWIFAFWQFHIGDSGLSIFWAVFGILLTLVPLATAFLLSLLRARRISSTSPEINSLYTSFRYFHSIGVLYRQYRQKFHYFWFTPFILAMIARAGFIAFGPASAWAQVIGNLVVEFIVLVALLACRPHKDKKGDWLGAFLSICRLIAIGLLIAFIPDMNVKPIPRTIIAFVIIVFYGVPVVFLFFGFLWNIGYGYLWRKHSNRIEDGLEIERFSPTSSNSSVPPPMMKHVDAGTFVSSDAAAASRGSLSMGAGVAGTGAAAGTQLGRRSSLIEPVGDNVYEASGSSADGAAPFSPPSNAYNPYGKEESAYPYDPHYSQMAYEQAAMGRRGVDGAGSPIDEKQWSGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNR2</accession>
    <name>A0ABR3BNR2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YjgF-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612792.1">
        <property type="nucleotide sequence ID" value="XM_066759305.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991699"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14244" checksum="04F842C2B65EA274" modified="2025-10-08" version="1">MPAKYTFVKTDNAPAPIGPYCQSTKYNGTIYSTGCIGLDPKTQEVVDGGIEAQSRRTMLNAQALLEASGSSFDNVVKVTLFLKDLQDFAAFNAIYAEYFKGEAKPARSCVEVTKLPKNVLCEMEFIALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNR3</accession>
    <name>A0ABR3BNR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPX2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPX2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612797.1">
        <property type="nucleotide sequence ID" value="XM_066759310.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991704"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027329">
        <property type="entry name" value="TPX2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06886">
        <property type="entry name" value="TPX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPX2 C-terminal" evidence="6">
        <location>
            <begin position="615"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="571"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="630"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="630"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0245713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="678" mass="74721" checksum="45058DD9E1AA60A4" modified="2025-10-08" version="1">MPTQPPPTPWLPNSRFADQSLLLEAQPIFDASFDDESMWGGETMLVGDDNKTQEGKNLDASANGDTEDEVMMDMTLDLGDYLPDEVDQKEVQRKDKATSHGSNRKRGVSETSSSAMSTNTTSDSLTSSATASSRLIHKNEGSQTMLDVSGPSKRPRRMMKKNDDLFSRRLSDSNRRTSLTPIPQISIITTSSSVVKTQGEKGPKANNIPSSSFPSTSSSSQSYRAPSSNTASARLKARLHADDPKSKPPDSSTSYHARQSETSRQTQIMTEKGSALSRYLAKSTVLATKERHEVPAEKGNQKVPNPCTSDSDNTKQLFTALSKPPPVQNVTPTPQSHDNNESTIDVPHNDSSEKKKLRRSSMGEKVVNFISGLIRPATPATVEIDPKEQKDEERGKENLLFDPLGAGPTIDKEERVQAPTSQSDHPVRRKRNEDVSGPGALTKPVPFSRPLHVRAPPRRDVEAKEQPAKQRPHISKTTTVSTCKAAIRAPLQSSRSQPNTKSVNKAGPLSPKSKSNPFHLRPATRSAFASAALAKLPPPGKGHKVAIEPIKVRDVEKGHDIAAIRDVFERLSSTSSSSFNKPPTAGSCAKSHANRPGVLQRTVPLRGRTPGKFSALRAQQRAAFDQVVKEKMEEKERKETEERRRREMEEEMEYRQRRKETVIRANPVPEMYRGGRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNS9</accession>
    <name>A0ABR3BNS9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104866</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612815.1">
        <property type="nucleotide sequence ID" value="XM_066759328.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991722"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="166"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0245731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="658" mass="73233" checksum="6846C44178CF6D53" modified="2025-10-08" version="1">MSIPPPPPSNKSPSSTVSPSKPRSPKLKPFTPTSEKPSRTNDDDQAYPPVDPHVLAEAVSKLDMIRSAPAPMSTVTSPVASAAPSGPSSPKLSGVNPGASSTGPWAMDRTTSGDGRLSAPGTPHFGASTALLKTLDETTKVIRQSSRAPSRAPSVSGIGTVVEKPDYSEAKIVVAMVGLPARGKSYLSNRLMRYLRWLEYNVQVFNVGQLRRSKARSALQAGEGKVDHSATYFSHSNAEATKRREELAEESLESLIAWLKKEGNVGIMDATNSTIDRREKIKKRVDKEPGLQVLYLESFCDDPVVIATNIALKVRSGDPDYQGMSKEDAERDFRKRIAQYESIYQTITEPHIPFCRILNVGQRVTINKIEGYLQSRIAFYLMNLHLKPRSIYLSRHGESMYNVEGKIGGDSDLSPRGWEYARALPALIKDNIGMGPLEVWTSTLQRTQQTASYLPFEKKTWKSLDELDAGVCDGMTYEEIEQKYPEDYESRDDDKFNYRYRGGESYRDVVVRLEPVIMELERQNNILIIAHQAILRCLYAYFQARTQQELPYINIPLHTLIKITPQAYGCQEERYPLPIAAVDTHRPRPSKGKNTIAASVAGENFTPDQPVKRDYYGDSQQGVGFGLKPEAISQALENEMEQGKLTPRAARGAELHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNT3</accession>
    <name>A0ABR3BNT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612799.1">
        <property type="nucleotide sequence ID" value="XM_066759312.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991706"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="95" mass="11528" checksum="902C7433252162BF" modified="2025-10-08" version="1">MVYVIVVHLQSLPEHVEEIKAKLKEAAEIYRNDKETIDWHVMQDPKDETKFCIVERYEQESSQQYHLGNPYWKTFDPYVVPRLAKPMDLTRWEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP96</accession>
    <name>A0ABR3BP96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612980.1">
        <property type="nucleotide sequence ID" value="XM_066758532.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990908"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="5">
        <location>
            <begin position="447"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="401"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="811" mass="92234" checksum="23949EC6CA61AD84" modified="2025-10-08" version="1">MPSLVVYPSMTNAFSSHRPSVRSHVDFIIPGSGSQRSTGRIVKLELPSLVRSQATDKLDPLFKSIDAILAGQPTPLSYQHITTICQAVVLQDRDAASQLSDKCTRSIDHYTERISRELRGSILARDRDTLGKLCGSWQVWTARTNLLSSLLVHLDKVYHSSFSDPNILRSRAMAKYKSIVWQDTVIHRVIIDDIFRWLSEERQTGTPSTARPTMLAVDKIAQTLQTFAELATAYQDETNDYYTSALRNAVSEIEKGNRKAGEYAPWFLAKIAEEEDRIRECFHTFALQPLSRDLRKVGQTETTDKIIDLAVEEAMSNDEAKGFSELYQFSIETDKFASFVKSLENYLSNRVSTLISDPANDPHMIDEILKLKRFAEKAVSNLFSEEDTKPFLADDDVQMISVEEKEEREKEMENAREKKQNVRMRMFELEEAVRTGFKTGMGSRQNAPAEWIAKHLDAAMRKGQGSGTEEQFNNHLDEIVALIGFTKDKDVFKAFYSSQLAKRLLLNKSASNDQEENMVAKLQKELGEEFTSGDVMMKDLQLSETLVRSYQLAQSRDPAQYGETSNFTANVLTESAWPAYPLLKDGWNFHLTPSLQSSIDAFTSWYTTQHKNRVLSWRFQLATVTLTARFPSGRYEVGVSLFQAVVLLLFNEVGSLTFAEIKERTGIEKNELIRTLQSLALGRKGTRVLLKKPAGKEVNPADIFVWNKAFTSERIKFKVNQIQQDMSAEESRKTNEQVTLDRVSVLEATIVRIMKARKKVTLQLLIDGVVSDVSKRFPPDVKEIKKRVESLIEREFMARDEEDRSILHYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPA8</accession>
    <name>A0ABR3BPA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612685.1">
        <property type="nucleotide sequence ID" value="XM_066759198.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991591"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="463" mass="51051" checksum="13222FF2C80DDF8C" modified="2025-10-08" version="1">MASTTSSLPPTSPSASTHTMEPSQPQSSPLKAPSIIISPSKNPVMERVASQQLNSSPGPQWATENNPHPKAGGSHTGGSPAPSVEGHVDVDEEIDELLGDDDVQEGAEEKDGEPEKQKCQWGECKDEFDSKQEFYGHVKDHINASKEYACEWRTCSRVGHKQGRSLLLTHIRGHTGERPYSCTIPGCNKAFARTDALNKHKRTVHADVTNPNGAKPTKGAKGKTKATPGTGKSKGKAKGVAPTPSDVSTPTPAINSKPKSKSVPPPPLILSPSPPIPPVSAPDEDLILDPELAELIPRLRSRWPILPEGDDEVEALREARRKFPRHRLFPNYTKEEDVEENGGQVVLEELVADPLDDPIARPLRLDGEDEIEYRRRVREYLTNTSKSLDADVPMEDLENTLPPLVPEITHTTEDPEDPEGGMVDVLDRSRWQARYIMAKARLLLLEEENMLRRRYLQELTGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPE2</accession>
    <name>A0ABR3BPE2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612474.1">
        <property type="nucleotide sequence ID" value="XM_066758987.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991369"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="39" mass="4263" checksum="70E8D1D3B54E1119" modified="2025-10-08" version="1">MADGGYRRVEIPTFLKILVVPLSRIIIGATVAIYSVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPG0</accession>
    <name>A0ABR3BPG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Endoplasmic oxidoreductin 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_104092</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613019.1">
        <property type="nucleotide sequence ID" value="XM_066758571.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990948"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047128897" description="Endoplasmic oxidoreductin 1" evidence="16">
        <location>
            <begin position="19"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0247058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="63675" checksum="211926B35ADA5550" modified="2025-10-08" version="1">MRLSAKLAVFSLVAAVSAQLDGLHSRGKSAFGLEHKPDSRVARNVLEGKSEGYCSPSGPIESTHCLYETVESLNQQLFPILHELVETPFFRHYKVDLYKECPFWYENGFCMNRNCGVEEMDENEIPEKWRARALSEVKVSSEDEGVSSCYFKEQDFCYVEDDADANGQYVDLTLNPERFTGYAGDSAHNVWRAIYEENCFGLSEASLSEMSKASVGISGLGSTGKSGLASAVVGAGGVSRSSKSLNGAPGWGFSKLSEGWGTEMVKAPLNGEEMCEEKKIYYRVISGLHASISIHICADYLDQITGEWAPNLDCFISRLATHPERLSNVYFNAVLLLRAVARAAPYLKAYDISTSPPGLLKEGDEKAKTRLGEVLSLAGGQGMEKGFDEADFFAGEDSGILKEQFKSHFRNVSRIMDCVGCDKCRLWGKLQVSGIGTALKILFELDDKALDPKVNPDLLQRSEVVALFNTLHRISESLASVGQFRQIYAATQKLETEASKVKAVKAARKKHSPLPMTPPPAFSLTNIQRITVRVWEKLGRNCKGCLEVCLQTLESGKLGELATSFRRWVGGIGEDRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPJ8</accession>
    <name>A0ABR3BPJ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translational machinery component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612703.1">
        <property type="nucleotide sequence ID" value="XM_066759216.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991609"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0245619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32274" checksum="55ACA063ECFECE66" modified="2025-10-08" version="1">MASIFRPALLISRAPRTASSPWTGAAGIVANFASSSRVRLDTTPSSFSRVNTTSASTTTFVREEMPEPLPSLVAEEEAERSVSAHQSPSTSNPNPDPIPNHQIPPQKTSPVPQPNSLRTSSSQSSTPSHIPQFTTSRQVARSPYAGLRWTPETVDFSYPISNSDLTPTHTLHIRSTRNNVLLTLTDGLGPLFGTVTGGTDRTFKNAQRSTYEAAAQAAIKMFERVAEWSRETKMNKKHEPKLRISYNGLFGSAREAVTTTLAGPQGSDIRRLIVRVEDRTKVKIGGVRARKPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPS7</accession>
    <name>A0ABR3BPS7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein LTV1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613139.1">
        <property type="nucleotide sequence ID" value="XM_066758691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991069"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="67410" checksum="91F908B831821817" modified="2025-10-08" version="1">MPPKGSIFRGPNAQHFQLVHRSQQDPLINDPEASQRVLKPMGRGNDSRKTEISLAELEATIDKSKIRANEGEAALYGITYDDSAYDYMQHLKPVGGSGGGVESFLIAAPSGGSGVASGMKGGKGKFKARADDEMFQLPESVLPSRHEISVQEARARNEAIPLELQGLQPDMDPHLRQVLEALDDDAFVDDEDDEGWFNQLVKGGERDNHEEVPWEFAEWGVDESGKPVQRQPEQNGEREETWEDRFKAFKQEQARALEEPSEFDPEEMSEIADTVGSLTSNLADMMVRGGKKRHGKRGPSDASGMSMSSSSMFRNQGLRDLDDRFDKIERDYEYDDDEEEEEYEDWSDDDGTASIAASNFSVSSRFSLASHASRASTSVPPELSREDFNAIMDDFLENYEVVGRRLRPALGGTTLSGPEKLKVLRSAIEGEGDFRDDNRKRIKEIEKEEMGKGRTKLREEKVKIIGEEEQKWDVETILTTRTNTENHPALIRDPTRKIRTVPAPPPPPVQLEEDSEDDSGSETEREGGPRVTIARTKGESADEKKARKAAVKAERSARRAEKKSHKETFSTERKRQLKSHNKMVGDGRAADVPAGREGVYSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQR4</accession>
    <name>A0ABR3BQR4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AP-1 complex subunit mu-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613153.1">
        <property type="nucleotide sequence ID" value="XM_066758705.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991083"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="167"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="435" mass="49749" checksum="8112682FF743A723" modified="2025-10-08" version="1">MASLVAILDVKGKSLIQRSYRDDVPPSYIERFLPLILEMEEDNVPVTPCFSDEGVNYMHIRHNNLYLLALSKKNSNAAEVIFFLHRLCSVLTEYFKELEEESIRDNFVIIYELLDEMMDFGYPQTTESKILQEYITQESHKLEVQVRPPMAVTNAVSWRSEGIRYRKNEVFLDVVESVNLLVNASGSVIRSEILGAVKMKCYLSGMPELRLGLNDKVMFETTGRAARGKSIEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLSTPVKPLVFVEASVESHRGSRVEYMVKVKGQFKRRSTANNVEIYVPVPDDADSPKFRASVGSVVYAPEKSAFVWKIKQLAGGRDYLMRAHFGLPSVRNEEIDKRAPISVKFEIPYFTVSGIQVRYLKIVEKSGYKALPWVRYITQNGDDYVLRTITDAKTAPLTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQU8</accession>
    <name>A0ABR3BQU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104441</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613366.1">
        <property type="nucleotide sequence ID" value="XM_066758918.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991297"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045123107" description="1-phosphatidylinositol 4-kinase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="869"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="666"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="766"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="824"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="772"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="844"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0247405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1173" mass="127628" checksum="A1B7316FA8E2A051" modified="2025-10-08" version="1">MSHALLLRLFLSPYFSISIAMQYLKTYPDSIGISHYLCWRMKRMPAEEVEFYWPQICHLLLTYPTQSNALESFIIARAEESTHSAMLTFWFMQAALRDLIPTRQTDPVPFAICQRVLHRCHAIIFGDPPEPSRSPYRSLPQSPSASALGKLSSISAGPSGIQIDEGQREGQGLGQGRVNPHATAALVGMGVMLAGTPGMPALVPFVGEWALTQGRRPMNDLTSGRDRVEVDTGGGADLRPEKVERRRKENENDREEEKEDSDSEEEDGRAPTSGNTHEQGYKSNVKFAKSTVNLTITGPAQTAPNLYSPPRSPPALTPFSANDMLDEKGRETEKNGGISRRKGSDPFGQLFSERSPTPSKSAHQPFHSVPSLPRSSSYNPYHYPGGPPAAEAILATYSLSAQRQLLRSHYCRSEVRFLLLLEDISNRLLVIPKPARVSALRAELTSLNHNLPAEVCMPLWCTADHIHSPSSSSSNLTPSPSPGSNNPSSAAKNRAYHPRGSAVPGGHSRVVRISPGDSVVLNSAERAPYLLHVEILQGDLDFDPTRRENRELLKKIVVAEDRKRRKRDGMLSVGEDGSRAGAGTRPNPPEEMDLVEQLYGTLSVHDEIPDLSEIIPLPSGPKNRDLDMKAWDRGSPLPERIANSGVNAGVGIGSGVMGDAGQWVASPTGTAAGSEIGKSGPSTPGFASAKSGVTSPAPSSSSPLTPGLAQDQGQSPSTPGTKRAITLEDYSERMRTAAVMLAQLNASLVPNAPENQSGGGWIPGTGWIRTPGSGGSGGGEEAGGKPDGSAGGKLKLAAAQAAAIRERIMLEMMALEEERVERMTDRPPGADLPIPTAEASGGGDEGHEHDHERGTAEDEGIVRRELNKADPSAAVFRESWSAKKSRIRAGSPWGHLANWDVISVIVKTGADLRQEQLATQLIERFSRIWKEENCDCWARFFRILITGETSGLVETVTDAVSVHSIKKGEYAKRLAEGGPIGHVSLMDHYVNTFGKPDSGRFARAQRNFIRSLAGYSIITYLLQIKDRHNGNILVDQDGHLIHIDFGFMLSNSPGNMGFEAAPFKMLMEYVDIMGGLDSPGYAYFKKLFKEGFEAARKHSDSLITIVELMQKNSKLDCFALFGDQTSAHLRERFQLGLTTQAIDAYLERLIVTSTGSNYTKLYDTFQYYSQGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR43</accession>
    <name>A0ABR3BR43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613617.1">
        <property type="nucleotide sequence ID" value="XM_066758215.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990589"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147:SF1">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="697" mass="74884" checksum="4B013739C2A99714" modified="2025-10-08" version="1">MSIIHPVPSPTSSSRQLPLQPYPSFPAQQHYSTLPPSPTHPPAPQLSPATSTSRLPHGQGQSKSAPVSPGGRLTLYGIAPLSSISPIHLTQQPENVRQWISSSTNSPPLDSAGCREADSFHTAAGSVGSGSLSKQAKPRPRRLSHLRHSSIPSSSATGSGSAGENGSGGYLSEEGFDSDATVRPGGSKYKHSLSQPDLTAFYEGRAKGLEPKEGMGKKDVKGWVGEVGRGQVVAQVAPPAPQQMGHQQRQQERRRPSLGRAKSSGETPGRRTGVSDESWLPAAPSRSPHSRSQSSLYGMRKSPSPRTQSLSVPTMSPINPPAVPLTEPSPKVLRHTLAMVSSIEGNMSSEGDDSSESGESLTFAPKRTKSLPVGSELRQRFQDPRLSAHRGSSSSRSGDGWLGLSLGSPSSVPNTTSTSAGSLSGLETTPKTVPQPLPSELERMIRRSSLLYLRLLAIVPAVWGICVLAQALVTGGLWVDVWPYGVDLSKEALERLVAGGVMMEGEWIGVNRGDMVLCIAWAICTGYFCFCLTTGLTHRWLSYYSLPSTITRLASLQCLCWPATYLTLWVLGARNARPLLAWVVIGVTTGWSRTVQMWVTSNVVPADLVSPVVSTNLVVTSTLTNPNVMAARRGSKQTTMLLGPPPEHLRQWEKFVWGRKWDWDAVASEVGWKVGGLLLVTTAWLFWGIECGNMVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRD9</accession>
    <name>A0ABR3BRD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613721.1">
        <property type="nucleotide sequence ID" value="XM_066758319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990694"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039646">
        <property type="entry name" value="ZNHIT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 2 PROTEIN FON -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555:SF0">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="372"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="411" mass="46610" checksum="E295A772D892AC21" modified="2025-10-08" version="1">MSIKQPKPLQIRLPFKVPRPKKSIPDVRVCGICRKNDSKYTCPRCNVAYCSLDCFKNESHAQCSEPFYKTTVLDSISADPKAGLEEKRAMMEMLRRFEEAEAEGGNGLEELESEDEEDELINRLQGIDIDSLDSNQLFKLLPPKHRDAFIQALQNPDSEETRALLESASDELIPQAPDVLPWWESEEILDDGENEGKRNKVEPEPSLIPQEILLEIKPPEGVGQKLVYNAISIGITYLHTLLSFRLPSLSPTHLTSQDLETLDIKTSLGELVPFLVVPKSTVRYESIGSAWGNVWEAIGSKMSSPPSTQILRQLLSTISPLLHPPITTPSYPKLLLILSDIYHLYTIPPGKVGAAVPRKLAFYVKALEQLERREWLELENGIRKELDKLEREEDQEVQFYEKKDNEKLKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRJ1</accession>
    <name>A0ABR3BRJ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin reductase</fullName>
            <ecNumber evidence="7">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_103880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613763.1">
        <property type="nucleotide sequence ID" value="XM_066758361.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990736"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="90"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0247802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="429" mass="47054" checksum="6E922ADC0C8F801D" modified="2025-10-08" version="1">MAGSRLPYQKKRRLEHSPRRRPFSPPSFFKYPPRFPFVFPSFKSKTSHPPYPSQLGLSLRPYISSPTTKDPISSREPKRTGEVSKKMHSKVVIIGSGPGGHTAAIYLARANLEPVLYEGMLANGFAPGGQLTTTTDVENFPGFPEGVTGTEMMDKFRAQSERFGTKIITETVARVDLSVRPFKYWTEGEEEEPEFMTADTIIMATGASAKRLFLPGEDTYWQSGISACAVCDGAVPIFRQKPLAVIGGGDSAAEEATYLTKYGSHVYVLVRRDELRASKIMAKRLTSHPKVTVLWNTVATEAKGDGEVLTSLTIKDTKTGKIRDLPVNGLFYAIGHEPATALVKSQLELDEDGYIKTIPGTSQTSVHGVFAAGDVQDKKYRQAITSAGSGCIAALEAERLISEEEADDENLMTENVHVPAEHYLGTDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRU8</accession>
    <name>A0ABR3BRU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_104434</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613359.1">
        <property type="nucleotide sequence ID" value="XM_066758911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991290"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="369"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="636"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="728"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="729"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0247398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="843" mass="91177" checksum="B4C5190D534F7E6D" modified="2025-10-08" version="1">MTKGKATKQKTIPKAAPTITPPDPTHAIAHVPTHTTDEKRELQASTKASIATPAEVEEDVCFICAEPITFWSAGVCGHKTCHVCAVRLRTFYKKTDCTFCKTPLPTVLFSRSPDTPFPNESHLGPSPADVISKAQEGAKKGERWDKGLTLPGTLDLGAFPYVDEKLGVVFEDEDMMESTLTLLRFNCPYPECSFQAINWPSLERHTLSTHGKVICTLCRSQLSRFAHEQVLFTPHLLPLHDPSRLKRGQRPPKPRGPKEEEEVKSWEAPHPMCEFCHKAFFGPDELFKHMRSDHEECHVCREQGNRHVYFENYHKLEQHWRDEHYPCTQPQCLEDRFVVFGSELDLRAHMMEVHGNQMSARDRANARHLPVDFNNPSSGSRGSTHPAGGRGFSLGQSSISGAGRDSSAPSRMRANDSPHVQALDDTPAMTPAQIAQQRRQIQADRAESMAAGQNMSRRRGFATGLSREGEVAPSPASSAPASGYNTPREDVDEVIASRHAELLSRVSMLTNDSATKLASFRSAVRSFKNNESGARDMVDSIFNVFERDLDVTIGIAREVAKLFESEGDKDKAKDLIEALNTLRVEQRDQFPSLGSAPSGLGTNWSGVASGTILNAKRATRTSGTSRAVWDRVEAAAASQPVNKPRATTGIGGRWVPGAGGSRAQLNSESAFPTLGATQSSAMPSKAVGSSSSTSGGAYATPWAAGGAGPSSRTPSALAGPQIRSVHNPAAATTKKNKALSSAAFPALPTSSGSRGMTAEERKALFSKPTPREESIKRITGQANAPPPVNSWKAGSSNGQGEVDAMEGLSLDEHAAVQGQGRQQGGGKKKGKQKQLLFSVSARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRZ1</accession>
    <name>A0ABR3BRZ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glyoxal oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613901.1">
        <property type="nucleotide sequence ID" value="XM_066757517.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989871"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045876894" description="Glyoxal oxidase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="3">
        <location>
            <begin position="92"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="4">
        <location>
            <begin position="486"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0249714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="69445" checksum="BF6B6C697D869FA4" modified="2025-10-08" version="1">MTSLNMVTLLTLLPLLPLIVATSLPSLGTASGQTADKRGSSKATTPLSFQSVGDTGVSAQQMFLGNNKKVYVIDKAENNPITVNGAYGTHPAWATEYDIETNQYRTMDVYSNTFCAGGNVLGNGTWVIFGGNQPVTTGGVASTDAAAYSDTDGGSAIRMINPCTDESCEYIQGETNYNKSQGMGGWLQMTGKRWYPTVETLEDGSVIVIGGDKNGGYVNTAAQDNPTYEFFPPRDGDPVDLQFLSDTLPVNLFPLVWLLPSGKLFMQANRKTILYDYNTKTTTNLPDMPYATRVYPASAATAMLPLTPANNYTVTLLICGGSNTTQWGNDGSAGYNVTAVPTDNTCVRISPDGNNPQYEDDDYMFEGRSMGQFVMLPDGTFWMGNGVAMGTAGYGNEMYSVGQSYGQDPLYMPALYDYTAPKGSRWNRTGLSASANERMYHSTAILLPDSSVLIAGSNPNADFTTSQWRSRTDSEKWYPWFYNEKRPTYDGMPTNLYYGGASFNLTMSGTDENAAKNTKVVIIRGGFNTHAMGFGQKMLELESSYTIDMNTGNTTIHVSQLPGNPGPTLFQPGPVMFFVVVNGVPSIGEFLMVGNGQLGTQNTTTNSALPRALSILLLLPLLHQASLVRPLCSRVGWQWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS30</accession>
    <name>A0ABR3BS30_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613095.1">
        <property type="nucleotide sequence ID" value="XM_066758647.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991025"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="114" mass="12851" checksum="3F93DBA30AFBE10B" modified="2025-10-08" version="1">MQITRMRKGKLVYPLMWVKLPYRGIGASICKVVEELADDLAITPEDVITDPVPAKELLTVEYPGELQMISFWKTGMGIFALRTSAISYRHQRRFLVPFLPSGLTMAPESTDAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BST1</accession>
    <name>A0ABR3BST1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease III homolog</fullName>
            <ecNumber evidence="7">3.2.2.-</ecNumber>
            <ecNumber evidence="7">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="7">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NTH1</name>
        <name evidence="10" type="ORF">I308_104127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="7"/>
    <dbReference type="EC" id="4.2.99.18" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613053.1">
        <property type="nucleotide sequence ID" value="XM_066758605.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990983"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="9">
        <location>
            <begin position="170"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0247092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="454" mass="50246" checksum="07B9BC57D04253BE" modified="2025-10-08" version="1">MSRRPNLPSTKSVINNSVAIVTADAVKEELPSPKLTYTSLRRSTRSSVTAEGPASPVRNSKLNIAKYEYKGPTPSSRKRQKIDDIVKKEKVETKTSPIKSPAKKPLPQVALAKPHSAPAKWEEQYQLIEKMRRGFVAPVDEMGCERPRTNAEGDPKHKTFRFHILISLMLSSQTKDAVTSAAVTSLHTSLPGGLTAASLATAPLETIQECINKVGFWRRKAEYIQEAARTLLEQEGDEKGDVPKTVEGLCKLKGVGPKMAFLALQCAWDINAGIGVDVHVHRITNRLKWHRPPTSTPEQTRLNLQSWLPPHLHKPINPLMVGFGQVICLPVGPRCDICLLGQKEICPSRVKGANSKGRKEVVYSFKEEGDEVAVGQWRWGQAKGVESEAKVEIGYEEGLENIEDEESVSSIKVEQVIEEPGMRRPDEVLEILDQVDGPTDIGAEPVIKTENVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSU0</accession>
    <name>A0ABR3BSU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614213.1">
        <property type="nucleotide sequence ID" value="XM_066757829.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990185"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="51018" checksum="A4D788CD4D094CC7" modified="2025-10-08" version="1">MTDRGLISSFLQTTAGEWFMILSLVFGGCCSNVWALEGVLKDHPKSGTFLTFSQFVFVALQNLSSQVELARSKSGVIYPKLKTRNVPLKRWIIQVILFFAVSLMNNYAFGLKIPVTLHIIFRSGGLCVSMIVGRVIGKRRYSIAQMLAGLLITIGIIIATLSAPHRQSPRSSDTVSTTAESTGQPTSWMAHERDYIAGIALLAGALFLSALLGLYQEHTYRMYGKQWKEALFYGHFLSLPLFTPFYSDLIQTYNAYTSSPSLTLLSIPRPSTSLFSALFTETPTSFSSAKYFDWHELLIPSAMFALALNLITQGLCVRGVNRLTTRVNSVTVNMALTVRKAVSLVISVWYYGSGVTWSLVIGGGMVLLGTILYSLAPGPKGLGPSPSDRDKPIPTPKTKTSSRPRPILVEQKKGDAIGDQWEDAEITKAGNDSNLQSDPLVSAGLRYRQSPMEGSVMEKNATKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSZ8</accession>
    <name>A0ABR3BSZ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613764.1">
        <property type="nucleotide sequence ID" value="XM_066758362.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990737"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="280"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="386"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="498"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="656" mass="73092" checksum="49DFB2F55AA88B9D" modified="2025-10-08" version="1">MDAGYDALEEAASSYAKSRDRADDTRSHKSHRDRDYEREDRDPERRHRRDDKDDRYRDRERDRDAYRGDRGDRDHGRERDYRPRDRERERDRGYEARDRYDRFERDGRGAGGFEERPPRRRRRDEEEFTLAAEPMHGHRDRRPRYDEPPEFAEPMRGNWSPPRRKRDDGFRGGRGDRDGGRRGGGGGGGGGGGGGGRFYEDRRSPTPDGTLSLEERKEKLSRSLWDTAPVQFQGVSALEAKTTGLFTYGPGRVPPPAHLGIPATFVAGAFPPSNPVRQNNRLYIGGIKEDMQEKQIQDFFNNLMKEKGMADGKEDPVKQCQINNDRNFAFIELHTPEQATAALELDGVVLDGASLRVRRPKDYAGIDPLLQTFNGVVAPSVADSPNKLFIGGIPTYLNDEQVMELLKSFGELKSFNLVKESAGVSKGFAFAEYLDPEVTDMAIQGLHNFALGDRNLVVQRAAVGRNTGVNAPIPGSAAYLSQAIPHLMQNNADAPTSRVMLLLNMVTPEELYNDDDYNDIIEDINDECSKYGEIEGVRIPRPVPKSKKWESTEAAAATAERNKRTDDEAGVGRVYVMYKDVESTKKAMNAIGGRQFAGRTILVANVPEEEFLGPAPPPPPPEDAPAPAESDAPPPPPPADLDAAADAALKDIMSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSZ9</accession>
    <name>A0ABR3BSZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytosolic Fe-S cluster assembly factor NBP35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NBP35</name>
        <name evidence="10" type="ORF">I308_103217</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614101.1">
        <property type="nucleotide sequence ID" value="XM_066757717.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990073"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="88"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0249914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="336" mass="35811" checksum="7E6A3C72B8C1DD43" modified="2025-10-08" version="1">MIATQRPFPIPSPVPLAPSSTVLPTTVPENAPQHCPGVESSQAGKADACEGCPNQSVCAEGPKGPDPDLPLIRERMSSVRRKILVLSGKGGVGKSTFTAGLSWALAADEECQTGIMDIDICGPSIPLLMGLQSSTIHTSASGWSPAYALDNLAVMSIGFLLPSSSDAVIWRGPKKNGLIKQFLKDVEWGDLDYMVVDTPPGTSDEHLSIVQYLKEAGIDGAVLVTTPQEVALQDVRKEIDFCKKVGIPILGMVENMSGFVCPNCKNESQIFAPTTGGAEAMGKELGIELLGKVPLDPRIGMTCDQGMSFLDEYPESPATIAYLDIVQRIREILDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT24</accession>
    <name>A0ABR3BT24_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_103544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613440.1">
        <property type="nucleotide sequence ID" value="XM_066758038.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990400"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="152"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0247479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="397" mass="43939" checksum="1FB0D00CFB74D07A" modified="2025-10-08" version="1">MPTYTPIHDRPPHYANFPSPPSTSGPPKSLRYSSPDIDPDTPLPRMSSAHESDPVEQVNASQPGNSVSRQGVRSQGAGQEEGHSRKRARTSPSHSGGNGSYIPRERTEESLHSHHNGHSDAPSGQHDSGQVYRPRHGPVPLTGSIFNLSPRNPFTSVVGDFIMNAAMGHSNVEIELKLGTFMTPSMPGQQPRRINMPTLSEMIIPHDYPNGPFVSTINHLHHRTLNELLNRAVESQSTLPTGRLYFSRSKLADSFYDYSEHGHGKVRVSRDMDSGEVVQAVEKRRIADMNVYCPGMAYDFRISVNTETPCEVPTGEAKSVRYKDRACYKHQVCRVDLTSVFSSNPRNAAVPPSRSFELEIEVLDVPALLAEGAAQSERFDEILQNLLDSARMLVKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT90</accession>
    <name>A0ABR3BT90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104277</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TOG/XMAP215 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613203.1">
        <property type="nucleotide sequence ID" value="XM_066758755.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991133"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="3"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="283"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="459"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="684"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="948"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="1346"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="522"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1217"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1609"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="632"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1256"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1635"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1657"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1724"/>
            <end position="1734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="2025" mass="216599" checksum="6FCC273461E8543D" modified="2025-10-08" version="1">MNGDPPAEEDFSQIPLVERSQHKNWKARLSAYNDVISGSAKTASDTDPFFQPFVSDGALLKKWCLDANVVAQEKGIEAVLAIVQYSGESSARLRPEVVPAIVEKALGSARAGTKRKSMDLCAMFVEVENGGEGVMNDVLEGLSAKLPKAVAGAVTCLKGIVESFGVPTMGNTKPLLKSLPKIFGHSDKNVRAEGTSLSSVLYTYLGPALLPALSDLKPVQISELQKSFESMDAEGKGAGSGRPTRFTRKMQREREAVETAGGDEKVGADEAKGEAEEAFDPMSLLDPVDVLALFPSDLDSRLSSTKWKDRLEALEECNKILTDPKNAKILDSNADAYGPLAQTLGTKCKSDSNVNVVMEACKVIEGLARGLGKSFGRHRAVVMPGMMERLKERKASVVEALGKALDAIFSTTTMQDIAEDVLTSLKSKNPQVKEGTLKFLHRSLQTTLDAPGKDQVKPLAEALVSLLGDSAEPVRSTAAESLGTVMKIIGERAFNPYLENVQEIQMAKVKDAFGRAEIKYRPGGMKKPAVGPRPAAAPSKKLAASKPTSLPSSPPIKTSGKFDGGEDDLIEEFVPPKRAPPARFARPGVAKSTVAPPSSPPIKSMPKIDDEDVVVNDMAPPKRGPPARFARPGSTKPPAAAAPAPSQRSAPAAAPPTTKAVSAAGKSGPAKTLTSSPNDPIKFKFSPEDAAAQASDLIPSEFASKFSDSAWKVRLEAADEMVKWVEEEGVEKVDAEVILRFLGKSPGWSEKNFQVSSKIFQVIQIIAQKSPTFGKPAAALAIGPLTDKLGDLKLKKSSGDALSTFAERISLAFVLAQGYEPMSKQKAPKAQADGLLWIKQQLIDFGISGIPLKDLISFVKTALGSPNAQVRQSATQVLVTIRIAVGADISGFLEDLNPQLLSTINSEFDKVSSQAPPEPVKDQVELKEIVAAPGKGGKGAGNSDPLDDLIPRVDLDKLVASTSVIAGSKSDAWKVRKEGFESLNSVLEVKSNSRLKPNMGEIGGVLKKAMADTNLSVKLLALGIISKISIGMGQPFDKYLKLLAPAVASVCADQKATTRTAALNTLTAMADSVGGLDGFYGGLGASLETANPALRSSVLGWLAERLHSEPPSPSADMSPLAGPVIHCLEDRNGDVRKGAAAVLPFIVSSAGFDYVMDQTSSLKPASKATIVPLINNARANAPSLAASSVGANGVAPAAPAPKFTVATKTVAASTPSIARVRAGATRTAPGSPGTAAGPSLPKPSGVPARSLAMKALSSVPSSRPLSSLNQNDDRPSGLPKSRMALLRPISATSQAAPSSVASSLPSTSKIIPFLNSASEGRTARLKRDTVRWVLDPSPKASADLYEYLHHQMESQVAPELLSLLFSKDHRAEEDFMAGLAMIRELYDQQTCGSFGLDDHEIESRQLANVDMALKYAALKLLANNTQLANRCLEVITHVVKTMTRLNQRFSDAEAKLFVPALVFKLGDPKFVPKLAPIFEALDKVIAASQVVALLVQYGLEDKSAGKTCKNESLSLIEKTYRKRGSILRTRDDRSFFETLAKCISDSATRNAALTVMALIQLQGESKSLHAVVEAMPSSSKDMLANRRATMATGKTNGQGQTLAKTSIDVASQGDLSSPRITKRAGLPQPRPSQIPSNSNSAESSPKSVSKAIPSPTIKPTRTTTDSPSQSRTIHPPSGLSRPSAMPPSRLQRPTDVFGGGNSNAEAPARPTALQPLGRPHAARHSASSRSSGPSVIEAINDIRHDDLDRCVDALKTIQSMLNANPDSFVDNVETLADTLMDEMEFAFTPPENLNNPRFFRVVKHLIQSFSGLSSNQTLMRRMSYEQLYTVLNCFSFRLVQADRMGGTIQELSRFINLILVQCLSTPDRLLVFQVMFRLLLDLTHDFSVTQPSPESERAAHADLVIKCLWKRCKILEDDFRSGRLKPGPILAVLEEFLQDVGPKEYRKRAQQGIALGDMPLRTVKTIIQRLLVYTRDTGLEIYDVLVEQFGDKAASTIVYTYVFRLAGSEASRSASPRSLNPPGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTQ5</accession>
    <name>A0ABR3BTQ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102503</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614517.1">
        <property type="nucleotide sequence ID" value="XM_066757048.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989360"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF21">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="493" mass="54532" checksum="717A9779B108E6E2" modified="2025-10-08" version="1">MPRRKVAMPYHPPTQSPLSPLETRWGLMTYTLSRVPARKLPLLVAYALTIVKLADHGWISRESLGKGGGSIVGVLSMVSGLLLSYRFSSAIGKWDEGKQVWSEVRTTIRDGIRMLSTLPSGTVKQLPLDGYEESSDQEGKDKQKLIRQRIDELSGLLVSFAFALQHNLQGTRPLPQAPLCDLLPSGYLSSLKRTEARVRFAENHAGPSGSRSNRPESGRNKDSSTDQEESDQSRELGSLAFRAEEAISKLSKAAATMDPVDTYRNEELQQQLSQLNFPDDSVEPPSQISDSSFTFTTSETSKPPKSNLHSPNPPNLALAILKLMEVYIEGMREIPEDEGGWDLPRRERGFNLVKALSGHLGKAERLSSNPPPLPLTLHLSHLLVIYLAALPCSLLCVVDGWLLVLITLIAGWCLLGLEALIGEVSGVFGSSENHHPLPIFTEQILSESLDISPPFLRYHKARVIARVGRNTKEVLELDRRGRKGVEDWVPSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUJ2</accession>
    <name>A0ABR3BUJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614795.1">
        <property type="nucleotide sequence ID" value="XM_066757326.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989647"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045044615" description="Acid phosphatase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36422" checksum="5FA6EACB5DCFF1A8" modified="2025-10-08" version="1">MHRFASAVATLLILGFSQAQELSCPSSKVNIDPCLSPSPGGLFVFRQRFEPDVGGDSGSWGIDGLEILTCDTQQPQNGTAYAPTYSHEEIGSFCLKSILFSEENSFANAEKAWAQSEVGEGVEEVWERAWNMAGRFISNFHPKCYKDAQRGNGVPEFFNVLQKLHWRFPTAQLLSNSDITPSEDISYSLAELTSALTKGGDFPVVICDNATLSTILWPLLVRGSFAMGTFEPTSMLQRESNCPKDGIIYQPSTRRPLPSTTATWDRIFRPSPRPITLSHDESKLYYRTQVPDDLRQKLALFKGYDQGKEEEKVERADKKFLRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUN7</accession>
    <name>A0ABR3BUN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614831.1">
        <property type="nucleotide sequence ID" value="XM_066757362.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989683"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="7">
        <location>
            <begin position="43"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="459" mass="51272" checksum="4AEEB2E71A3D13EA" modified="2025-10-08" version="1">MSNVFPYPPRKVQDYPTFLPEQPQPIGSLLDDNEYKQNKNPPKLFHPITIRGVTFHNRAFVAPMCMYSSDQGRATDHHFVHLGSMALRGWGSIMVEATAVVPEGRISPEDMGLWDDSQITELQRIVKYIHANKGVIGIQIAHAGRKASTPAPWNERLANERGHSQGSVVPEENGGWPSKVVAPSEISFKAGDYPDPIEASIEYLESLKKAYADAVERCSKIGFDFIEIHGAHGYFLHEFIDPISNKRTDKYGGSLENRLRLPLEIAQVVREKWNKPLFYRLSATDWLEESIGKEKNANGEWAWWGIEQTTIFVGKLAELGVDLVDVSSGGNDLRQKIAPGPSYQLPFAEHLKKTYPNLLIGSVGIITDAKQANDILEQGKADVILIGRQLLRNLDWPLDAAVDLGVAVAPAVQYERAWTRMLVKREAHDRTSKEHGITELQGQEAQESKTPPGEHHSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUX9</accession>
    <name>A0ABR3BUX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614916.1">
        <property type="nucleotide sequence ID" value="XM_066757447.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989801"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="9">
        <location>
            <begin position="56"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="793"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="940"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="813"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="940"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1024"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1171"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1275"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1285" mass="138630" checksum="DAA2F2767B71CB27" modified="2025-10-08" version="1">MLEYDETFSVISIVVACIASRIACLSLGEPKSCPESVIMLLLLLLFLSIAGLCVQATPLQSTFSSCLFAYSPIAASENLLNVTQVFATLVTGNEAAELGLTGDGHDVLRLDLVGITGAELSGYDNSTNKLATLFTDTHAATARVYSSTTWLCNSLFPSILPEPYHPYNTTYCPLPAGDFAINISIPLYRSYALTTLHTQVRIVDTTVEAASLACLNIHVSPYKDSGWYYHLFRYWLVALVAGFWLVSWGARFVTGWIVGSGVAEYGQKELAGIRLMGGGSNNREATMRKWGTMIISGLSGERLSVSGGLLRFGAWANLVWNTTLVQGSDPTSKQVSVYPNNYTVPSQFSTQMTDPQYPLYLDADAFNPVLDLHNSPDGMESFATAVGLRPQDLFGTCLAIFLCITAAVIILSLLLWFLHGLSEYILTKKHKQISPAAKRTTLGSSPRGSLGGKEALDPQASSSEGLGVFPTQSAFFSHKSSSPSPLRRIWLRFRSRGEAGAFHAAALYGNLIRLILVFHLPVTIFSMYHLCLGSRASIVSRAFAALSFAFISVLIPAYILYRVFETPTGKLYDATRTLLSIGPMYNIYVEKKQMFRVFSLSASLITGIVVGAGQKSGIAQTIILIVVELAMLIIPGVWYPWGEGASMGAPNAFLTSLRLVSMVLTMLLSPTISMASTAADWITYAILIVQAIIFVFFLLMLLTKLIEGSIRLFGGVHFDESTHPLDGGIFAAIMDLDCLNPVRGGKAAERRRRKRDSRQLHKNVYAAGTLTTQMMLDRHSQGVLRQTVSEGSTPMLYPVGYQPPLGPPPVDQRSSDDRSDERPSGGDNIMDAWRPISGSGYVPPGAYAPTVTSPTSPPPDSPFSNFQYEPNRGFSVVRGGRSHYENPYDIQNLNAGSDTSMPTMAMPVPTIRVSQIGQRPMSPPHSRQKSSSAIIELSTPPTQTVGLPQTTNPPSPSASQSMRPNNEGMRPPVLAIPKRRSLNDLKNENDPSPTSQYSESKRQKKKGRRNAGWFHRNETRAGDSESEESDDEPGPSRRKARKAALMTSGIREPEPFEDISKFEQQSGWKKVLGIGKKGLDDLAAQERDENKARKAALATESGSLFAGVEAPKPSPKKKGFVVTRRSGDRPGPSPVSPASPESQTGTSFKVKRMGQPTPTPTRVESPAQPESAQASPVSLVSPASPVSGAIGSAAGPGKKSFQVIRPAVKSSVASPMESGGSAGFVVNRRSPQSTPLEKTPTPSPPPEQVGYAASLLVPISQQGGSAGPSKDPRASSGSQQVYHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV05</accession>
    <name>A0ABR3BV05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger ZPR1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614695.1">
        <property type="nucleotide sequence ID" value="XM_066757226.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989542"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="6">
        <location>
            <begin position="312"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="524" mass="58297" checksum="620636DE140C483A" modified="2025-10-08" version="1">MSSDKTNLFPTLGEVADRTGMTESAGLEQEGDDKQIQEVESLCMRCHENGTTRLLLTSIPYFKEIVVSSFRCDHCGHRDTEIQSAGEIQPKGVTYTVHLLTRADLDRQIVKSNWATITIPDIQLTIPPGRGQINTVEGVIRDTVRDLNISQPVRRVMDPETAKKIDELLEKLKAAIDMEEEDEDDGGVGIDDDEKPVRHELSNSSSKEEKPFVPFSMIVDDPSGNSYFQFKGSQSDPQWNMRAYNRTFDQNVTLGLVARPSDMSEEQPEGVPIVAADHKLSSVEEFESKRNKNVIDREDGTVVPDEIYSFPATCSSCGHELETLMQQVNIPYFQNIIIMSSNCYACGYRDNEVKSGGSISPKGKRITLKVEDEEDLSRDMLKSDTAGLSIPEIDLVLQPGTLGGRFTTLEGLLNEIYTELSTKVFRSGDSSTAGIGQADSNIGEDEANFGNFLKGLKECMSAQRKFTLILDDPVSNSYLQNLYAPDPDPNMQIEEYERTYEQNEELGLNGMVLEGYDEEAEGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVB6</accession>
    <name>A0ABR3BVB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">OPA3-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615037.1">
        <property type="nucleotide sequence ID" value="XM_066756260.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988564"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="99"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22048" checksum="773037492B698DED" modified="2025-10-08" version="1">MASVKIFSLAVKTLAKPIANTIKAQATQHETFRNICIGLAQRMHRTEARMRMGLLNQEAGNIKPLNDTRAIQNGATTLAETFLFFVGAGLIVGESVRSSRKDTRRRDQVQDRLETLEEEVKRLSEQLEKDNQDGVKGIDEIRERSERMEQVLRTIVNNGVKAGRTALGHKEGEGLVREGQLSKILAESNGQVPEISVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVH2</accession>
    <name>A0ABR3BVH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101791</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615120.1">
        <property type="nucleotide sequence ID" value="XM_066756343.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988649"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="459"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="576" mass="64513" checksum="5C3232E6F6B50C30" modified="2025-10-08" version="1">MEATHTPRSVLTHIGSWKLGKTLGRGAYAHVRLATHKNGHQAACKILPALHKDPGVPVTWDETIDAVEAHKEVVLLKALCGAGMEGVAGLEGVIEEGGWTYVFLTLYPCSISSLSKPWSLDAVVIFFRQLLHTVRNLHQLNVSHEDIKRSNILVDSQGFPMLVDFGFSHFKANGGYVKSAGGTLDYSSPEKTADKRYDPKANDVWALGILLTKILCIQHPYAHSYADDTSTAVKRRILTGDAKFHWKPDQLVPGGVAELMMGMLERDPQQRWTTTQILRHPWLRTRYPDPKPFQLPSYEPTLLHRPSQNVIEDVCFLAYLNGEFALCETSLGIEERLEGKEPCWEKRWAGMLGSWSQRAEMDWQDIPTAITPLLKCRSSFTRVNGPPRAKRAEKPKGGILKEIHLLPNEQAPPSLRSNEDIKRGIKPVRSRLYNMQTKEGAQKLLEKFVPEDLMATANNQGSKAKSSIVRVKKTKGKQKSKAHFKIFNSDTEDSGKEDEVLEKRQNQRGPRNLDKTGANKPVAGKSPISAALVTTEGFITSLADEQMKGLFLSKPDPPQAKRRSPRLQEEQRVDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWA5</accession>
    <name>A0ABR3BWA5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_102048</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615376.1">
        <property type="nucleotide sequence ID" value="XM_066756599.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988906"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="14">
        <location>
            <begin position="262"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0252656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="776" mass="85148" checksum="106603E578AC528B" modified="2025-10-08" version="1">MLRLPRITRRALSFLAPSALAPSALAPHFDRPLPPPPPAPLAPLCELPPLTGPDALQPLTRRTVLQADALVARIAAAPAHPDPAELRQVVKNLDRLSDVLCGVIDMCELVRNVHPDPRWIEETEKTYETLCSFMNQLNTHRGLYDALIATVSHKFPGNPLSPAELKVAQTFLSDFERSGIQLPPSVRARFVRHSDNILSLGRTFLSFVAAGPSTGSLIEIPEPEVLLAGLSPKFVASLPRKKRKGPVLLAPGSWEAQMIGRYADNEEARRLVYIGSMREDKDRVHVLETMLKERAELAHVLGKETWADVALSDKMAKTPRNVLQFLTSLATHHRPSAAADVAALRPLKAFSLSAVTDSSASTRVPPTVYAWDRDHYAEQYAASLVPNGSLPPITPYFSVGTAMSGLSHMLSRLYGISFKPVPVLHGEVWHPSVRRLDVMDEYGKRIGVIYCDLFSRPGKPSAGAAHYTVRCSRRVDDDPSEGDGLLPGWDQDLGKGMEVQGEALHGKEGKYQLPVVVLTTDFGTVEESSPALLGWNDLETLFHEMGHAIHSMIGQTEFHNVSGTRCATDFVELPSILMEHFISSPAVLCTFATHYATNEPLPIPLIQAHLQLDQSLKALETHSQILMALLDQKYHSIKHGEELDSTRVWNELQSQVGVIPPVRGTAWQTQFGHLYGYGATYYSYLFDRAIAGKIWSSLFARNSTAGPGPRTPNDAAAAGDILSREGGEAFKEKVLKWGGGRDPWEMVGDVIGGAEGEQVAKGDEKAMELVGRWMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWC4</accession>
    <name>A0ABR3BWC4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615382.1">
        <property type="nucleotide sequence ID" value="XM_066756605.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988912"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10450" checksum="9E63E8C81A3C5D73" modified="2025-10-08" version="1">MRLSQVNKILLGSCIVVVPLSFYGGLAIKEYYLSKELDKVDDSRPPPHERAMRARIVQLEQERQELLKEESTTSLLLYTAAGPHAQKIINLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWI2</accession>
    <name>A0ABR3BWI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615460.1">
        <property type="nucleotide sequence ID" value="XM_066756683.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988990"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047444775" description="Peptidase A1 domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="198"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="523" mass="56256" checksum="98F4E3C2463FCCE3" modified="2025-10-08" version="1">MLSFSPTFLFVLLSLASLVVVAVPMATSVTQHRLKLRKLPVVRDDEHPIVAFERHYEAAIWRLHSYKRLPPRQRDYLEQLAKERRYMIGSDTMLHERTWTPPLLGKTRSIQSSKRAYWREGGNEPSGISEPLPKIHKLAINGTGMGAAAATSTVTASGSNANGFSQAAADAGNTLTNSTSELIQGGLHYTIYSNDIGYLCEIEIGTPPQSFLMLMDTGSADTWVPSTECLPQNCGNHLSLGANVSSTFQKSNRTFEVTYGSGAVFGVIGADTITVAGMTLDSHPIGVTLQESVQFADDKVPFDGLMGLAMNQLSHQDVPTIVDSLQSAGLIKNAILGIALGRFTDGKNDGELVFGQADASKFDPSTTQTLPVTSSDGFWQVAMSAVTIDGQDVVVNRQAILDTGTTLMMAPNDDAIAFHELINGSASIGNGMFSIPCTIEQVVTMTFGNVAFQIDVRDLIFQPITNNSRGSCVSSLSAGTIKNGDTWLLGDSFLKNVYMTTNVNDKTVQLSARMDAPGSSSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWQ1</accession>
    <name>A0ABR3BWQ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615535.1">
        <property type="nucleotide sequence ID" value="XM_066756758.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989065"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="149"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor tau subunit sfc3/Tfc3 C-terminal" evidence="8">
        <location>
            <begin position="1614"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="657"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="805"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="938"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1458"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1573"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="667"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="737"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="975"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1573"/>
            <end position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0252815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="2196" mass="246196" checksum="908C059234767A57" modified="2025-10-08" version="1">MLLHDLLEQCFEFIAMDGAIGCQPNVLQKHLSSINLSFDKTTFAYVWRSLCLQPAIEVILTSKLFTASAGQVAAAKGKKRKHDDQVDSHDLIRILREDDGAQKKGEEVSIKDYEALSAKWGDWLRIRCTKDEIYFRLTGQHERLSSLTADNFQVLQLIAMSRENGIALIDLDPSSGLEKVENIHARVDVLTDLGLCVRLSQTIRNSIGSILVHYKFLHLNSAYLSLCRLNPELQDTLPPDVSLSHMTRDEDGNDFVNETDEEEDQSVNKLRLGFAPLTETEVSSGHIIRERLLKTLDHPELKNHLLRQRGLLYALGWVGTVSTKQRRAVERIIRALVDSGVVERVAAGDKKILCIRLTKYRTELDNDALEISDNPKREVQKEWDCLQAIAHRAPYQSASGISMSQSLDYQVLDLIVQAGADGIIKNDLWRKLNFMVSRSFDQVIERVTVTTTPNHLWSRIIIRTRENESREQRHRYFSISSFLEVARQLGRGSDLGDAAKEPPNVGQFADIPNRPRYHEAREYLQLLGGAVMKKAIKSQKKDPKDFKYQDSTQKRGRPSTTIIVHDAHNGDRNRGIIGSIPVQPDLPARLVYDSKSGLVMTPSPLWSGKGAHPPFTEEQRREGKEPAWYDRYPHVKERAIPRNSKKARGKERLEVGTGANAGAVSNRELRQTKRIKSEVNGKENANKDSPRPLTTTTDPHVDSIRQGMSPDETPIDTSPSSLLNAKQRREVRENNRSRTISVSSGVNQMNSPVSGPAKESQWSNTPVARSSVVDDAEKHVPVIGSGLSEASKEVAKTLVNLSSLSQPSEPLSFSSPTPPVLSVHSRHEGSSGPLEIAASKECSDGGPRFTKSFTSSASSVDPEPAISSFTHVQAKTVEGDVKRKSSLVPASEQPPLKLARLVKGEETTNLSAGEARYNPDQRAVSLLSPASAATEVAMPALSPDGGGDREGTPLREMPPSISLTPVPARLKKGRSSGSTNRKSSTPRGLLDLRESLQAEELLQFIHDFGGIIAQAKIQNEHHAWTVKHAGSSHPHSPNRAYTMDRTTIKRALGALDRQGRLKHTTTQIATTLGTFSSVKFYYVPDLPSQQLNSHINRHRHETAQTGKLFRSSIATELPQTEFSDFHRSDPSGGKVAVASFEQATTKSHSERRSLLLTEKDVVSQLYGYKFGMFVRVRSLHCAIINALKAPDSPSIISTSPRIFSLTLLFEELRAKDWYAIMQYTKHMEDIVAWLGTPSNGETKLKDVPPEFRPPKGFGGSLPRDRVGRLLDVLATLKILTPLVGVDDQNGDIKIGEQMSFRVADSSVAPYYVLHDYAPVYHVALGSTAPLLGLLPVMIEGDIKSFWDKCREAVRDSTPIDLPDKVDQASSNNLMFPSIAHIKDPIELDPSFLRRMQNRASWDDKPRLTTLQQDAIRDAIDWSWAAIRITSPEALEKFAYENALPTSIVQAELHSGQKRARENIAHREERLRDSARRAQERQERRLRSYQERIAGEEAASRQAWEERVAASAMRKDVPYDSALLDFVSSKAPANMKKANVTDGLVDYWVGVWELCKEMDGEERDQLLAQGRVSLKQKGKTDKKLKRKGKGQKTTETPGQGEAPDVEGTTTKRKNRSKRKWTIEDDELMLDSEAIIRARSRTNAYKGRAAMSQLYPRITASTFRMRIMKIAGEPGKLAYLERLEQAWYELWLKHRGTEELPDENVESSVEFNLKAHIDYLRKHVDKRTLKLLAASTPITSGFHAPDLPFDIHDLHNQFDWDYSKTNRHTFDTVAESLSAEEIRLNNLARKSLIYGPAKGHAEQGSSLNREMGKLRAVMKLIVATPAATYDINCGERLLSSWDTSVRDMATAELVDAGIFRKYLVGATAGTGGRFYDFTAQWQQLSDGPLPTTFWEEAEMLETKLENAGDKGFEWPLIGQSGELGKLMSMVSNDEVEFSFNIKDFPAINIPHYNTRKLNDDAYEFDFQVKRSAPPRPPLTASAPDPFICKVPSPWNINSLDVEQSRQVLEAASRVVDAVIASGPEGITKSSLQSMLDLPIGLLEGVFRTFRKDPPAVFWSGYDTARLVAMEFWPSWTIRTRPFELKENKESERCTTPRRWLDIYGQVLHTEWVRAVNRVASHLMMRPGITQRRLRVKLDLILDRLELVDVLEYLVKKGIGRREWMGPEGMNMPPVVATSIEEEEWVVWSLDTNLSFSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWX6</accession>
    <name>A0ABR3BWX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615613.1">
        <property type="nucleotide sequence ID" value="XM_066756836.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989143"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06869">
        <property type="entry name" value="PX_UP2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="346"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1162" mass="129090" checksum="D632F7D7FCCDB3F8" modified="2025-10-08" version="1">MSDPSSPPEVPYKPYVPRRQRSIRPDRPLPPPPPEEDVPAVNAFERIQGYTSPPSPPPRDPSLTHVEKQLPPPPSAAPLQHADEQHQRASSSSATVPPPNFAPLPDSARHGEAQAQTSAAHLHPYHSTLPTSSDPPTVLTPLRAHYLKKTLVSLQVSHELALITDPVLGANALGLLGDPFVLPQQARQEALQRVSEIARAEGQVGDLPFLRFMFHQFLLPFPFLTAAPPTFWSAKVQPFLSSFLATTGISAQAAQTEQERKVAESLMSKDELKEAQERKKLWVKVEKHLALMFGLGIKLTNGEEVVRIGQAELKRLEALQEERRRKWMEKHGGQQYAEAQATGFEVNVIGVRLVVEKGRVRNRSHEEFIIRTSRHGVSDVFVSRRYGDFRRLAEELRLAFPNSMVPFPPPKDKSTTAAPPPAPASTGYGYGTYNPLRAIYGSGTQSAQTTPNDSTPSLQDPDSPTTATNSGTPLSREKNRLTLRAYLNSLLTLPYVIESPILRSFLLSSPTALTPPEAVDCQRRLEADAVREEGRRRFRLEAEKRIEALREGLAKFKGDVLSKEGGLKNVFEVVKRVEKVEDLPEAEASVLEWGRISFAATIFQLFVASDSASDTLASLKRLHGLMPYFMLKGILKISNPMAMIRAVLDLFLARPFGGQSLIQRMFSSSLTEDLRMLDEDIEILQDKIDDPVLCQKIEQYAKAPFAIQEMFRKDAASEGHDLLIIILRSPDVPSLSRPQFQRVVKATRAYREYKASVAELSDSDEDEGPENEDAWLYEDLTILLKLWMRKREKEGLLALIFEGVTAELLKDIITIFYTPLAQVYKAASIADSLGDMQAFINDMIRTVEQVEELSQEDPQRTVQTFIDLVQRHEQSFYTFVHNVHSKGKGLFDSLMSWLELFLDYARSGLPSPINLEFILPHSEEERRKVLAEVDAVATYHYQLKVAHEEKIRRRFRAAAADNGGAGGMGDHIDDEAELLNSVMASLNIGETTMDEAGDLADEESEEEAEDEEGDERELEEGEEEKSDTSSMNLPPSPKQEAFSPPPGNAGTGQSTHDRRRSSHSSTSQSLKKVRSALKFKHGDDKKSSQTGVAGGTGEARQSSPLAQGSQGRHHHGHGHGNGKRRKKGGIETLTPPGTEAIATLRPLFVEALRPSLVVQPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWY6</accession>
    <name>A0ABR3BWY6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614553.1">
        <property type="nucleotide sequence ID" value="XM_066757084.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989396"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="39199" checksum="FEAFC8A5C2F4468E" modified="2025-10-08" version="1">MEKPGLQDLPPEIIRQIIEDVERKHPLLLLCKRSSIIASEYIYLSLDSCEEERHSVDGYIPSLSRLIEGLQHTGPTHDAPFGSDVKLSFLKRARKLQHAFGTYICFRESSSDDKVLEKITAVFQSLQKRCIVAFPSLEELHLHCTGWSSITPPNRRCAFALAAVSQPSLCYWPFIFSLDELPSLPLQGETRPENKIKREGKEMYRELKFAQGHIPDRVIHVPYKVPCIPSVCYGTLNVVSYSQLWSHPAWSVDETIDYLKSVLRYAHPEVFNQEGDVVQRLEQKEKHIRDKTLWAFLWVGRFTKKEGKTYGTMMKLVEAGLYEAVPCMKDRVKFCVRDVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWZ2</accession>
    <name>A0ABR3BWZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615634.1">
        <property type="nucleotide sequence ID" value="XM_066756857.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989165"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="44902" checksum="9373CB1A41534B86" modified="2025-10-08" version="1">MNIIQNGESSKSPYTHDINGDLTKADADVEMMDGENGVRVELGRPEVNNGDEDIENERKRGTARLIMPHWDVPPAKPIHSSQDLISLLHLDTLYNTYVRPFADLPGDEGQPGAGAGADGNDAFQRGKKKGTSMPGRKKMEKGYQHLIEDCIDPTPLGYKNDNPSLLPLLNDVLYPPAPPPVLSQGQIEALPKEAFAIAKLEPGTVQDGYAGGQKAGVREAEEKRKRKRTARTTTADIISPINPTFPGHGQGRSSTPGTPLLPVPPPTRGFPPGANTPRWGTAPPGQGGGGGGSGFQGVHPFARHGQAAGAGSGPGGRPFTQSSKQRPASMEVQGSEGGRKGLPSRSASPMPLSAGATPGDRNGGGGKGGGTLASASASVSGSISGQRQFPQNRNKRPGSADVQSLQTKKSKGGSRSASPMPGAGVGQGQLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BY29</accession>
    <name>A0ABR3BY29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_101833</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615161.1">
        <property type="nucleotide sequence ID" value="XM_066756384.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988691"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF5">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046620632" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="11">
        <location>
            <begin position="34"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0252441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="285" mass="29931" checksum="C197C4B4C31B7656" modified="2025-10-08" version="1">MIFSRFIFIATLTASAASAISIQRRAKITDFDKSPVAFAFPPPRGFSASSAADTPCGGFDPVNRTDYPMSDGEIALVQRTEAANVNILWTKESDPTMFHSFSTYSSSILEVGPGHFCQEAPDFSSLGFSEGDNATLLVIYQLPGSGVYYYQCADISLVSASNFTTNVQYVCGNYTSELEIASPEESLHLGNDTSAPKNTTGSSGYTGVASTSSGSTNPNLSGSLFGSKLSAASGGGIGASVTIFVIAVLAGLLWWSGLIHFGRKKQAAVHDHASVSSGVPTKERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYS2</accession>
    <name>A0ABR3BYS2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine repeat containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615356.1">
        <property type="nucleotide sequence ID" value="XM_066756579.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988886"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="517"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="637"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="702"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="817"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="928"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1030"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1492"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="637"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="670"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="884"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="955"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1056"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1582" mass="173850" checksum="02E064179A603C01" modified="2025-10-08" version="1">MAAASIPGWATDELLEEWPESSPSPPPALSKLPAIPQPQVNLDSVRAKRGSLRMLGQAAARPLPPSCSNSNISVSNGDRPGRIVSGHVDGGRGHVSGTGIDVGVLSPPSSVSSSDGRETLPAGTFVVKDGVEDDRGAHLAKNRMGSKDKDIFGALPLERMFDPPSPSVAMTGAATDTSQHTNHPTVSPEVFSSAPGPKLSEPLRKASHQYAPLNPSRLSKSVTPSSNDSFATTMSSAPSIVGPQFMSSKAPEADDSMLQNSTISRSEDDDSALCNAVPIVQQDHGARSTLTVTQQAPSQSERISSKSPIARLQDCSNYSFTFESPRQSSYQSNRDHSSPMRSPFNPEVEVAVEGPSHSTLNFRSRTCQTEFTNEDRSPPNPPLRLFRSTYDTYTREHLSALVDSIAVEPSPSPPGTVSVRLNNGSFSVDSSTSPSQSASSTHFNSTPSSASDVRSSKRLRLSPASPPQKRPLRDWGAQGREMMNRLRHVEESIDGASLSRFSGSDDQGVLDELVHSDYVNHSPSPPLKDDPPTYSAQHAEAEPPRHRSNPSTSSSGYLRAAEDIMARIKLRKVSESASDSPALCNDQRVLSPLDDNRVWEEHADQYAKCAKSKGKNRTAPSPRRMLRHLNAFEEIKRVADEDSASDDERSHDEVNPSLRRWPEQRRPTDQVLQANSNGSGGQSISHLPRFTADDINRYMSSSTHATSTTVSTSFVKHRGPRVAQNHGSSPAMRMIRPDDVEGVVPDKIGKMRYDRIQMRWVRELGPVDEAGESRLTGSEESVDVFAGIESLPGHLEDPSGSSGQLPTTHRLDESLREHEREIQENADDEQSGVERHETKSSVSITSDRDDDTVEDCPDLSPIELEGDATSEPMRIIEESKERSTPSSATSVFANASHHGAIHDVPSAPLLLTPTPSAFAQKPIRSALRNAATPADKPKKRQGWSDEATPGPIARNITSTSSGKRSVSFSDGKKAGKIIDLEVEMRTTRWQTSTKEECADIFKRESAVGDRSFLPSARTRRIQGLLDDMGEMTLDDETPCKPSSRQIEDTDRPFSRASLTSSPDSPSTVPIRSSHMGRSSTYASRHAGNATFLTECSFGVAHDKLVEIITDIEPFNPHWDQLKSIDLRDKKADSVARLKEFLPNLDEVNLDNNAIGYLSGIPTTVRTLHVAGNLLTSLTAVNHLRNLQYLDISRNKLDSVAQLGCLIHLRELKVDDNAICDLEGIMNMDCLIKLSCANNKLDMLDLSAAKWSKLENLNLSNNRIANVRDLHKLSSVASINLEGNRLCAFTSQIPMPSVRVLRFSDNDIAFFDISLFPKIRTLYADNNLLSHLGRSEHSPSRLENLSLRNQRSASLHLTFIDLENVRRLYVSGNALTEDFFPPRPLYSLVYLEAAACKMSQWPRDFASNAPHLKMLNLNYNYFTDLNGVKGMNNLRKLTLVGGRLGGEEAGKRDGRDVMAGLRGLQNLEELDLRMNPFTLSYYFPLLIPSPSPSSVLDPSTPTRNNQDRGGIGQSVAVPQAAWSPYDTRFRKNLPDEWYSKRLVYRGLIMQNCRKMRKLDGIVVEDGERKRANQLLEAAVGIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYX3</accession>
    <name>A0ABR3BYX3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615743.1">
        <property type="nucleotide sequence ID" value="XM_066755457.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987752"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0253522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="67" mass="7749" checksum="EC42CF4AE9697384" modified="2025-10-08" version="1">MERFVTGVYKQFLDPSCCIIMSSSALSTILENEQVSFAQRANVINKQYHFLLRRETVGPIKVKREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ42</accession>
    <name>A0ABR3BZ42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615888.1">
        <property type="nucleotide sequence ID" value="XM_066755602.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987901"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0253667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="411" mass="45563" checksum="6E05AE7E69D93526" modified="2025-10-08" version="1">MFKFDFHFEEEDDEQIQIPTTTFVAPTQSSQAIAGTSTSDKNDREIDRNCHHLSLDELIKTLPDAISYSPLYHQVLHTPLLRRDLFDARFQLINKDAADEPKKDATPEDEDEDNYVDAKTDLIPGLYEGGLKTWEGGVDLVEVLARSLLGSTAEEQDNNVGEWVKGGKVLEVGCGTSLPTAFLLRSLLSLPISSTPSKTILHLQDYNHLVLSLVSLPNLILAALPYFPPEVLRLADEGDEPIETVVPDLEEPGNLNLNKDLVEAFKTLLKERGIELKFTYGHWEGLSKELKEEKDGYGLILAAETIYSQDSMPALIDVLREAVRQSGPNEHKRDVELESSLEDLSVKDGWAKQPLREISRGLVLVAAKVLYFGVGGGLQAFLDAAEADGAYHSTVKEWSQGVGRKVVQVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZA9</accession>
    <name>A0ABR3BZA9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615725.1">
        <property type="nucleotide sequence ID" value="XM_066755439.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987734"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="40959" checksum="62915CBA6D7DB071" modified="2025-10-08" version="1">MAPVKVDSPRSVVAENGMTAGSWDVNGSGNTESEATGARLRKNPPRGARPSLGVDGDARLSHLDTIPSRPASPPYDSTSPSSTKLGSLTPTQTQTQRQSHPPPAPSTETGTSSRPVVTRKRRSSSIKRKPSPGKVPEKVVDWEIPRKTFHSSIGFLTLYLNHFAPPSLSPLLVVLSTLLLFVLVTDLPRLWFPASRYAELWEACVGFLMRESEREKVNGVVWYLIGVIFVLGVYPRDVGVVSILLLSWADTTASTLGRLWGRYTPPLPSHVPGIRFLPFAPRKSLAGFLAAAVTGALITIWFWGGSGAAEKTVGYGGGEWKVLTEGVWSSKGLGIVLTAGVVGVGGAVVEALDLGLDDNVTLPILSGAIIWAWFGFTDWLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZE4</accession>
    <name>A0ABR3BZE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615344.1">
        <property type="nucleotide sequence ID" value="XM_066756567.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988874"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="36638" checksum="9CB0710136BC7BA7" modified="2025-10-08" version="1">MITLTKTFHHPLISQPFLSLGLTSLALLLLVLVLLSVPGPIKGMYWFSVEGQGTTEGPLSAGVLGWCLQGTSNCTYAPLSENAYLSTMINTGEALTVRIMLPLACYWMIVVMVLWVLLTVLVPFGYRIRDLDSITRHLRFAIVEACVLCVSLFGNVLCWLAFGLGRSAYLSVQNGGGDPTSGRAMETTAVAALLSLLSLGTAVWGLHLRLQNAQSHWREEAVMLRRRSMALFASGAVRPEDAATLGVTGNFLEKKDGQRWSTNSSDVPSYTANSGALQHRDNGFKAGYQPDIEAGEEEEIDVKLEEARRNSVDQIRKTSIHDSPYHAANGTVRPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZL7</accession>
    <name>A0ABR3BZL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615797.1">
        <property type="nucleotide sequence ID" value="XM_066755511.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987807"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="5">
        <location>
            <begin position="57"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="543"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="705"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="817"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="884"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="951"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1084"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="582"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="672"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="894"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="951"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="967"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1100"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1131"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1154" mass="122286" checksum="E67CFA6D628ABB87" modified="2025-10-08" version="1">MSNTPLRPVHRPPLSRPSSAAPPLQPQLTGDRKPTSSSASSSQAALNQAGRADQVLYRFYLKTVAVLVEARLTHYANVSAEKKDRWFNLLLPEIELYKNDLQIYRSISSYPPYTQAELPSTSSDTCSIPPLLIAFILDTSDVPNGQALLWNRKGGKVALDLASLSSRGKGKGKEERPGIILERWTLRAQSSEPGDTSSSQIAPHTAYRLGIIHFRALHSLIRLFPAYRLYKRLRRSNSGLRLGIKLWGPEDYPNSPDGLKEAWGVMEEGLVSLDTSLGKLVFEGEQVEPENIERYDFPRLDLFGNGYTLQAEYRPEVDFSTEDMEAVLSEKFVDMDEDWFTPTVAARRRSGSNASGSSTDHSRTVRKSPMPAPIPSSNFTTSPIPPRQQAATAGSFASAGSFSKARQPSTSAVGVQSKGKDRWGALGEGLPFAGRSPSTSQIDGQAPPSPNPSGIVAARRLSGHSIQPFASASPSTSLLRGTPPQPLSGAPIPTSSTRPTIPASRTSSSIGRTSSFLSQSGRSFTHAQLANMYGGSASPPVTGAMSGVHLPSTPSQYNPPGQSPVSQSSLTFAKQPVPRNVPMSSRGMGSTPGSGSSPFIPGSLERDITTGTGITGTSAPNPPHIIKRYSSSFSSRPSSLTHRPSLQSQGSSADASLPSFLGGQGGLLRRTSTRESGLRHSLEPPKRRDRVPDEDDIEAFLKTLDAVPQPSRSQYAPSGRFTSMASSLSTREHRAEGEGTPNSQLAISPQTQGQGYNGRVPMTRAWVDDELKRMAGSFSIGEIAIPSRGDTTASSSGNVNTAASSARATMAGTPASIGLLSASRPSSASRRVPITDGGTEAGGQRIIRRKSDGPSPLSQGLTSAAERDSSLIAASPMQALHSADQVPADRGVRSTLSHSPAATGSARSLPRSAMGVTHEHPEPLPLRSAGAGVGYAGLSNYGATVVSRTSVLSPQTTGGTNSTDSPSTSVTTNATSTTAATTRMPRRGPVLLRGGFEHRSSATSTPSHSPVRDYARAGVAVNAASTSGAIGLGISTHEARVGSMPIRQVGDERERYTEQGRRQSASIAMIHALNASGAAPTIGTVGRYRPSSGTAPGSLGREEYGKREGREGTERRTESEGWEHSRKNRAEEEDDVADDELAGLMNGLGFEKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C044</accession>
    <name>A0ABR3C044_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616224.1">
        <property type="nucleotide sequence ID" value="XM_066755938.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988240"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="179"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0254003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="346" mass="40376" checksum="F00CB06E39B3F9DD" modified="2025-10-08" version="1">MASLFPYQHAYSHNSTMLSSITPTALHAPFYHTTRPNLLPFMSDKHLSLAAPVLAYWLYSFFFHFLDTAQFSYFEKRRIHDSPEVLARNKVTVMQVIKAVILQHVIQTVLGIFWLEDDEAIFRREVMKDHLAAMSNLSPWVADGVLLVLGRRVGEQVLKSNGEAIVRWMYWWGIPALQMLLAFFVIDTWQYFWHRSMHTNHWLYRNFHSHHHRLYAPYAFGALYNHPVEGFILDTLGAAIAEEVSFMTIRQATLLFTVSTLKTVDDHCGYRLWWDPCQLLFANNADYHDIHHQGYGIKSNFSQPFFTNWDKLLGTRMTREEADSKGRWRGVGDEHILEQGPAKKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C060</accession>
    <name>A0ABR3C060_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616241.1">
        <property type="nucleotide sequence ID" value="XM_066755955.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988257"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05510">
        <property type="entry name" value="Bromo_SPT7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22927">
        <property type="entry name" value="HFD_SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="68"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="400"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="483"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="772"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="779"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="851"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0254020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="867" mass="93936" checksum="AD1F0F44E5A18B64" modified="2025-10-08" version="1">MKASPPARCTAHPPQYLLSFLGDVPHAPNLADPAFQQLLVDVQSVKGAVKISADAFYDSLENIVNELKTSPESVPFQKPVSKREAPDYYDVIKRPMDLSTILRNAKARKYKNKAEFAADLDLIWKNCFEYNSQESHPLRAAAQFMKQKADHHLEYLADRTERNKQLQSLLPSATGTASPSLSSVAGPGPGPAVVLGSRLRDDASGGGGGGVGGDDEDAAGESDDAFGEGDAEGEVVVVDDDDRDGNDFLDVAGQGFRGGGAETRGERGTPAGRGTSVPLSSRLNGQVNGINRPSPSPLPFAERPPLTTTLDNVPALLRTPYSIPSLSFLSLTHAGPSFSDKGKARETLRAYPPPPWYPVPSTSLHAQEDDQEGEEEEESRLEGAWWGKMMDDESLITGMPAIPKMVPPEPVTRYRPKPPPPPPPPRLPNGIASGGDSEALHSEHDKKKKAVSVKAVVRRTINNLNAARQAMQRITEFQRIEADGGGILPPRGLSPTPAEKEKAEDERIERRDSLRIENKAARERRITQGGEVGQEEAVRVMKKCSAGMLAHAGFEGANEMALDVFTRMAVDHLDGLGKTFRLLLDGFSHKMTPEEIILHVLHENGQVEPKDLEAHLKNDIEREDVKIAEMQRKMRQTFYEVATAPVIQDDMMFADDGEMLLDGNFADELGEDFLGLRELGIDREYGLTSLTVPQSLFYGRRKRLANSANGAGGKSDLAYPPPPPFIPLAATTLTTHVPALLHAFYAARIEAGHSLDEDDAFEPAHSQIGSLGQILVKGKTGESKGDGKGKGKKREREGEDETGERKKSGKKQPGVGKGNWTRPSKEEKARLADEKNTANSVKADAAAAAAGDEDAVGEEEDAEGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0J8</accession>
    <name>A0ABR3C0J8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_101539</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616380.1">
        <property type="nucleotide sequence ID" value="XM_066756094.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988397"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="385"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0254159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="468" mass="53426" checksum="DD734AE4C5EAA41F" modified="2025-10-08" version="1">MTLNLDRYGEDWAGALTLLDVIETFFDSRLDLFNRRLRAQSNRLKSRAVEMLPKQLRTPKGGGILLLDDEGQDEGKGTERNKSRGERYKEDVEREVERIKIKLAAKVTHLSGTWKSEQVVRTKDKVSFLFGVLSLAFTCLLIYTYHRKAWHYFLFDLCYFVNGLDLLWIWVFPSSTFLFICCYLLTLGPLASAIITWRNSLVFHSLDKVTSIFIHIYPPIVLTVIRHVIPNAEEKYSGLKHVGEYKWYTMILLSSVPYILWQGAYYKFISVDRKSKIESGERQNSFRYLLNDKRGPIGKALQGIRPEHRELWFIFGQLIYSIIFMIPPSTLYIHSSTASSTFLIIIFTVSAWNGATFYVEVFGRKFERELEKLRKEMEVISATMTPSTSAVGTSPAVGDAPISSPLSSAEQMNDAEDDLNDSPLVLPDAQGTEASKEAQIPDLSLGKAIKEIDNEAEDQVTIRQRKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0U5</accession>
    <name>A0ABR3C0U5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616470.1">
        <property type="nucleotide sequence ID" value="XM_066756184.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988488"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="216"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0254249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="453" mass="49503" checksum="0A1A175D7DDD9A84" modified="2025-10-08" version="1">MKSQPKTHPPPLHPQVDQAPGYDPHDFLARPASHPHHGHTLYTYPQDVDQLFVHSHYRYLDPSHRQLSLSLPYPTIPSYPISRGAFTCTPNPSTNTTTNPNASSYSTRQPPPPPASAPELPATGTGTGNGERSGFQVDYTRVSSREAVRRPRIVLEADEFQKMIVLRKGADSKGADHNEVGEIRPPPLEAYIVLRPHRGEAGLGWDDGIPGDIPTFEKWSYELEIMQSPTRGRALGLHPLSRGFPPLSAPLIVQLVVRDGSREIIPPSDAALSRRLVHTVMMVDLVSPDGRESRGVVRVREGGDGGIYCRRNFLGGTFRLSSTFRSRLPLLSYDNGKGKEKGTGKGEGKGEGEEKGEGKNVFVFSEMAVRTPGEYALVVRLLDIAGPPHLGTSIGVTRSLAEVLTKPFTVFHSSEFPGSVAVTELSMGFAKQGERNLGQRKARDVMASSEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0Y2</accession>
    <name>A0ABR3C0Y2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphotyrosine protein phosphatase I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616262.1">
        <property type="nucleotide sequence ID" value="XM_066755976.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988278"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="4">
        <location>
            <begin position="7"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0254041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="165" mass="18562" checksum="A5CEAD5BFB35A489" modified="2025-10-08" version="1">MNFHLSICRSPMAEAVLKHQVTLRPESFSSNFDIRVDSAGTGAYHEGESPDSRTVAVCRKHNIPISGVARAVDKHDFQEYDYILAMDRHNLETLLHRKPASSKSHITLFGSYDPSLPQSSIGHPKTRASAIEDPYYGGRDGFDKSFESCVKFSNGFLDWLERNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3H0</accession>
    <name>A0ABR3C3H0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616285.1">
        <property type="nucleotide sequence ID" value="XM_066755999.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988301"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0254064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="84" mass="9360" checksum="F1AF756CE4463041" modified="2025-10-08" version="1">MYSWAHWIFHSLATMRQLGDLLSHTYTRGKGGSGKCGEYTWEFGYKDNQFAGFLPSADIEAQHHNSLAIFMAGIRSCGQLCPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3N3</accession>
    <name>A0ABR3C3N3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_100031</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616512.1">
        <property type="nucleotide sequence ID" value="XM_066754611.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986889"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1077"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1115"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1185"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="88"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="718"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="672"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="692"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0255235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1329" mass="149088" checksum="0F1ACA5FCF1CF396" modified="2025-10-08" version="1">MEKHKEQQCLLRNEICTNHHLPKEQLPRVKCRRWGGGKDGKKAVWSVVDLRSPFFQVTARVQDKVSLVCPVFWAEKGDDDVMTWRPGMRTPKKDEPGLRKGERYLLKNFSGVVKSGELMLVLGRPGSGCSTFLKVLAGHRDGYAGVEGDVKYGSLLPGKDFRPYKSEVIFISEEDLHDPNLPVGHTMDFALRMCAPSRDSRLSENPAGNGMGRKEYQDKTKWELLEMLGLTHIHDTKVGDQYIRGISDGEKKRVSIAEVLATKASVQILDNATRGLDADTALRYAKILRTLADIQRNTMVVSLYQGGNGIYDLFDKVTVIAEGRVIYYGPRAEARSYFEDLGFVPPEGGNTADFLTAVTATNERKTREGLVGPIPTTPAEFSALYERSDIAQRMREELEAHLTHPALDEQTKEFRESVQNQKDRWASKCRPEKVDFRTQVLEALIRDYQQRWGDKCVDCWLGLFLRGGTLFLSLFFPSMISLSETTAVFTGRSVLSKHKGFSLYRPSALLLAQTIGDMPLYFVMIVMFTLIIYFMTGLQVDPGLYFIYLLFIYFTILCTIALFRSIGYAFSTFNNASKTSGFALLMLSMYAGYIIYPPQMHPWLSWIRWINPFYYSLEALTASEIYGLELACGCAITGAEPNSVTLDGPLWVETVLDFHKSHVWRNFGGGGKHIRNAQKDGASPRDEEDGPDTSQLNEKSQGTSDDAAAEVHAVNSVLTWKNVCYTINANGQPRQFLNNIFGYCKAGTLTALMGSSGAGKTTLMDVLAARKTDGDIHGEILMNGKQLPISFQRTTGYCEQVDVHLPQATVREALEFSALLRQPRTLSNKEKLACVNVIIDLLELHDIEDALIGTSEAGLGVEQRKRLTIGVELVSKPTLLFLDEPTSGLDGQSSYMIVSFLRKLAAAGQAVLCTIHQPSAALFARFDQLLLLKSGGNTVYFGAVSELTNYFKKQGVTIPKDVNPAEGMIDIVSGSLSNGRDWAQVWIESDECKERLRELEELNEAGVNVTTLEGDEYEFTSTNMTQLKLVTKRASIQLWRDTEYVMNKVALHVMSALFNGFSSWEIGDAYEDIQNRMFTIFLSVFVAPGVIAQAQPKFLRNRDIFEAREKKAKLYSWYAFCFAEIVAEIPYLLVCALLYFALWYPAIGFSFKPEIAGAIYLQMTLHEFLYTGIGQFVAAYAPHEIFAALVNPLLIGVLAMFCGVLVPYDQMTAFWRYWMYYLDPFQYLIGGLISRALWDVEVKCESDEYAVFDPPEGMTCQSYMSAFLSEEPGYLDNPNATSNCEYCVISKGSDYLKTLNLEEVDDGWRDIALTFLFVLTSYGMVSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3Q4</accession>
    <name>A0ABR3C3Q4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616545.1">
        <property type="nucleotide sequence ID" value="XM_066754644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986923"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="61003" checksum="6570F48494FEA8C3" modified="2025-10-08" version="1">MSSTNPERLSAFVSFPSPYTQSLLVQALVSTLPSLSLSLAQFPEDQPPALQWADYDLMSFDIPHRNPSKYLISSYIYRKALIRKHQLHNTIITYLAKCSHRKVPSILSPLPEEPVGDGDGTDLLGGGVPKGWIVDLQFADELDEALMDDLYDLDEGMRANEGKEEGERRWWILKPGFADRAQGIRMFSTEEELRAIFEEFEPPSSDEEDDDGDEDDDEDEQESGDAQQPAQSGVDGMIDMLAKKAVELGFNGEDDRDVDKEKYGDEEEGTGVMTSQLRHFVIQEYIHRPVLFDIAQISGEPPSPLEGYKFHLRAYVLITGAYTVHLARTMLALFSGLPYTPPRPTKNGQLDLRPHLTNTCLQTDAYGAPAPPEELVKLFWELEGLSALSCSSSPSSNGNYSYLHRGEVTKEWLDKTFAKVGDVVAETVKAGAECGSFGLQFMPNAFEIFGVDLILSFPPSTSKCTSLPIPTVTLLEFNASPDFHQSGDRLRPKLLDMFKGVIRLSVAPFFGVETAEDEEKEKGEMQPGEERWGWRLVGKGEVRGSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3Y7</accession>
    <name>A0ABR3C3Y7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein ypt1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616621.1">
        <property type="nucleotide sequence ID" value="XM_066754720.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987001"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="205" mass="22614" checksum="20B2DE66A1A26F13" modified="2025-10-08" version="1">MSAPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELEGKTVKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDRDTYTNVKQWLQEIDRYAVEGVNKLLVGNKSDLATKKVVEYAEAKAFADELGIPFLETSAKNATNVEQAFLTMSKQIKDRMGSSTMASGPGAKSTIKGLGQNVEQKTAGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C413</accession>
    <name>A0ABR3C413_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616648.1">
        <property type="nucleotide sequence ID" value="XM_066754747.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987032"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01791">
        <property type="entry name" value="Ubl_UBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="203"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="272" mass="31507" checksum="CD9495BE6AEA42B3" modified="2025-10-08" version="1">MPRSPSPSRDYDRPRSRSRSPPPRKKPKELSFYKKSSSSMGSLSHRRDPLDEPTSKERAEARERGEVPRRFGGTREQGVRNTMGNVPSASVGSFKRGGDPLDRYGVRGDPRDERRDEYRRDDSYRRDRDRDDRRDRDRDDHRRDRDRRDRDRDRDRDRDSGRRTDRDRDGSRRDAPPAAAPSSTSVPPQRPTAAPSAASMRLIEVIANDRLGRKVRVKCLPTDTVGDLKRLIAAQTGTTAQKIQLKKWYTAFKDHVSLQDYEIHDGMSLEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4G4</accession>
    <name>A0ABR3C4G4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616798.1">
        <property type="nucleotide sequence ID" value="XM_066754897.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987183"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="217" mass="23832" checksum="94F1524C1D785338" modified="2025-10-08" version="1">MFPNKSAVQDPAKGNAKSIEQASEDKLQGLVEENADSTDSSLRYAAYLRRVRDVARAGSRYTAYTSDVGEAFRPVVPPWVVTAAYGVSWAYLIGDVSFTTYKSSQLGPSPIESANMSERTRLAMVAVKRSVFQAVASMALPAFTIHTAVKYAGRAFAKSQNATLRRWGPTAVGIGIVPALPYLFDHPVEQATEALFEKLEESYFKKNVLESEPKREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4N8</accession>
    <name>A0ABR3C4N8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Conidiation-specific protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616839.1">
        <property type="nucleotide sequence ID" value="XM_066754938.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987225"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF1">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12762" checksum="C8B7896A871F22D9" modified="2025-10-08" version="1">MSEQHDHHVIGGYKATLANPKTSEEAKAHARQAINEYEKKKNSGSGTEHDHRVTGGYKAALHNPNVSQEAKQHAKELAKSRCEDSVSRLGSSSGANVEAVVIIVVLAGQILHGFLLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4N9</accession>
    <name>A0ABR3C4N9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616864.1">
        <property type="nucleotide sequence ID" value="XM_066754963.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987250"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="11"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="260" mass="28086" checksum="91E19ADC836A2E15" modified="2025-10-08" version="1">MAPTRPPNVEMATKRIKKEIADLAKEDLGSIILAPDETNILHWKARIPGPVGSPYEGGVFDVDIRVPHDYPFSPPHLQFMTKVYHCNVASNGAICLDLLKTAWSPALSLYKVILSLSSLLTDPNPADPLVPPIASEYRNNRRKHDATAREWVKKFALPKSNPPPAQLKPKLQPPVLRRTISRSLPAPTSPAPPPQVVGQRRVILEVGDSDDEGDIQILGDSSRGNSSQPAAVTTNGGGRQKRARTSGQGGSAGDAIVIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4P3</accession>
    <name>A0ABR3C4P3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pre-mRNA-splicing factor CWC25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_100401</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616873.1">
        <property type="nucleotide sequence ID" value="XM_066754972.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987259"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="156"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="215"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0255596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="434" mass="50466" checksum="10ED2D6DE5BE4375" modified="2025-10-08" version="1">MGGGDLNMKKSWHPVLLVNQERVWKAEKVANEEKKMLAQLRKEREEERQLEELHRLQEASTGKKRVEKLDWMYAAPGTEGGALGGARIGEREMEEYLLGKKRVDEVLGQGDKNIGAASREFIALQNANTVRDTAAKIREDPLLAIKKQEQAALAALMNRPDIRKQLRAAKKAKETKEREGETKEERKARKRVEKEERRKSKHRYRDSRSPPFDYYDDRDHRRHRDSYDSRDRDGRRTYRDRSDRSRTRSESPKREKGEKDYSSRDRDYRKRDDSRRRSLDQSPRKGGGNRWTHGSDGYRRDDHRDDRFRARQRDNHIPPPRYPPRDLPAPYVRPPSPSRSSVAAPVNNNTNTLDDQRAARLAAMSASADELYSSRSKSLAARAEEERREQESDEKMRQKYGKEQASANFFSQQSQLGLGEALQRRGGKGLLKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4T1</accession>
    <name>A0ABR3C4T1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616903.1">
        <property type="nucleotide sequence ID" value="XM_066755002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987289"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="265" mass="29316" checksum="9E46B0CD6A7C5497" modified="2025-10-08" version="1">MPKNAAQNEKTCAVCSQQPPKYRCSCCLVRYCSVSCYKAHKIQCNAVTQQQSEVHPIQPLGSEIGVRSQATEGASPECGSNREEQSTNDVFLRPLTSLNWPPEPDPSLFTDPLLKDDPKPLRHEELLRIAQSTSLRTLLADQTLISILQLLDTLRPPARHSALSKLLGFDPQSLSNTSNTLINGRDSPPPLDELLDALARGADDTMEEAVQEGGWWLNGPKNKVWITEREKKLMRLFAGSVCLAIDGKVEDGDLVWGQGELTWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4T7</accession>
    <name>A0ABR3C4T7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pseudouridine synthase</fullName>
            <ecNumber evidence="1">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616902.1">
        <property type="nucleotide sequence ID" value="XM_066755001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987288"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="3">
        <location>
            <begin position="114"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="495" mass="56312" checksum="815CA30BA49A1F27" modified="2025-10-08" version="1">MPDTAAPPPDIYPRGMNPRLRYIKPYWWPYKTFVKQRWIGRQLLEVITTEFRDRSMEYYRHALESGVTRVNGVVARPDLILRNGDRIDNTVHRHEPPVTNDPILILHIDREREFIVISKPGSLPVHAAGRYFKHTVLEMMESDYGLKCYSVNRLDRLTSGLMILALSGKAASKLAREFVEGKVKKEYVARVKGKFPEEEVTVDKPMMTVDRQMGLVIITPEGKDAVTIFNRIAYDPVRDQSVVRCRPQTGRTHQIRVHLQYLGYPIANDPLYGIPSVWGPSLGKGGVDLTPSTSGISQADALKARAGTSTPQSTDTDREYDNIDLNSPIRLSNQAREIIAKLRRQKDDAEDWIKWSEVIFSAKKAQDDLELESNPPTPQVVPRLTGRQEALKLPDPLPDDTLSPLKPPLYLPPGFCTECYVPVPDDPDPETLFIYLHALRYTTEQLGTWETPMPRWASADWDGDWRGWEEGAILPHALEEDRRKREAEAAKEADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C577</accession>
    <name>A0ABR3C577_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617044.1">
        <property type="nucleotide sequence ID" value="XM_066755143.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987432"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="656"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="748" mass="81722" checksum="1BA2678CC2522D99" modified="2025-10-08" version="1">MPDDLDPASLAAVLSAEYALIDPALIAALLSDYPTNTLLQNLDQIKEHLGILEATLVPDSDDPRPQESMYGEGESWSGSDANSGDRIRMDALGDRMGRIDIGDRDSGGSRELVSECGSELEFSDEIDLLKSLFPNLTHGEMQKALSSEQNLPGAIDHLLSLDLIRETEQRGYWVGESEEVLRPVVENCEIIKAKNTKTKADNVGSSLSSLTHSASKSKRKKKPKTLQTITLVDTLQRGARSLTPIPPVVHSVSSSSSSRASSPARDTKESNSATTSLATYLHELLPSLSISHFLWHLESTEYPSLYHATRASLTSIPRSRASSFLSSYNEDDISSGLLQDVYGVSLEVEGNPWSVPREERERHKDLEMCIGIAGQDVATVMDLMDLLVDLRTFQSHEPEPVSELFDTSPRHSISPSPPVEEEEQEQEQADDDDDGWAKPLAASTNKRPVSSLPGPVTRPVPLTKIPKSQKTRVVPGALPSSMANATDSFGVASPSPGMIKPHAVGGPHPTNWQTVRSKSRTKDRKSQQGQHPLAESIPAYSRGGATTHGLYNQRLSSSFHGEGDSQDKTQMEEYLYQVQVERARREAAIRAAGRSFVGGGRAVRGAVSGHYAREAREAAERIRHLEMRAAELVIASQLDSNRPTRPSREENRSKMIDLHHLTVSQAVNVSEKAVDKWWIKEREQRAEGWGTKGKESQGCLVIVVGAGRHSAGNRGVLGPAVAGHLDKAGWRVDKGETSRGYLVVHGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5A4</accession>
    <name>A0ABR3C5A4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617086.1">
        <property type="nucleotide sequence ID" value="XM_066755185.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987476"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="140"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="364" mass="41398" checksum="7D1DF21FB3EC14DD" modified="2025-10-08" version="1">MPSESPTVWKFELEKTLQACTNDYRDLALEQAQILPEPPSALLALRMIHHSHPHLIKGFSPLEKETASSYDWSRAETYKEISGSRRVTVAVTDDGLADSVRECHDGRKTFVKALETEMTVSQLIGKLGRSGDQDSFIYYLQSQDGNIYRDQPSPSGPPELEAFQKYIKRDVPWMKEAIGKQAEAVNIWIGDSRSTTSLHHDPYENIYHVLAGSKTFTLLSPLETIHLDQRFYPPSTLKRSSSGQLYPEYDYPDPSCGPRIPWVGNLCLPRSARSISVTLHEGDTLFLPAGWWHRVEQKEEEEGIAVAINYWYPSEILPERYAYERFFRRIGIMSGMEGLIPPMGDEESINSDEDDDSDRYSASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5L0</accession>
    <name>A0ABR3C5L0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617188.1">
        <property type="nucleotide sequence ID" value="XM_066755287.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987580"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF14">
        <property type="entry name" value="ARF-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="681"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="4">
        <location>
            <begin position="1022"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="844"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="877"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="972"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1154" mass="124542" checksum="4B148CC12C32FB5E" modified="2025-10-08" version="1">MSHIQVPFPDASPLPSPTTLSTASSDDVYPAISYPDHGGESTNNTPRASSGNISLQPSREVSSSSAAVRDTLLPIQPMPDSLLLKHTLSALDASATTLKRFSKSVLAYAAVVHTLSEQLEKAEDDLFGALGELGRWLETGYGVQTDRQKSGVWDQDGIRKVNREKRRREREEMDVRVEQGLKDVKAHLKRRGLAGGGAQTKYESSAKQFYHATGAYLAPQSPILPSHTQQTSGSLVHTSGNLQPTHDMAQAVRLAQWDLTRYTHHSALLSAVPPSSEECLNLLVGLYGWVASMLNEQPGVAEGMDEDAMAVIQQSSHVRPHQLRRSSTPAQTNQQLKSTLSSCLSQLSSTRARLLLAWARRDDQTRLLQEAAARRQIEYESACTDEPSGIKLGEGLGLGNIGSGNAMASVSSSGMEHKKLKKHKFGRSMGRLKDFLSPSSSSHSVSTISPVPERPSRASFDGLMRSDRRNEGITRISTTGIAKLPTHSEVLDRPIIVTSPTLVSSTAASTPTLITSPLSALTTISPTPTVPYPSGASSMPPLPPPKEYTRPYMPTRHSVQMPSGDYISPFIASTSASGSSDYDASLHLPSPFESSPDLHLSVGSGDQVRHSMDSSRPVSGIGYSRTSPNPSMASISPHPMPNIGLGHPTAAAIPGIIGTGVGGVGGLGAGGDEDELREEAGRKKEGVLWGLGTWEGLTKGSGSKGKWEKYWVVLDHSSIYEYRDNMGPPGGAHAVIDLKFASVREGRGTGRRFVFEIVTPSQGRRLYQATSDQEMKQWLYAICNAIESCINGTSTVRTMDHAKARGPSGAYDDHALPTRSKYNLGFSTRNLSLGFVPLVQTGRKSMPPTPVEAASGEARTRKTSFKKVLKQSGERFTNAMTGGTSHANLPASTDQPPGKAKRNSFGGLEVPRPTFGRAGSRQSLPASAPDRLPLQQQFNQLLPAISTPPGAKSSWADNDIESRVLKMAGLGLGASPPSRSGGGHGALPLAESPSSAKRRVKSEAIRKPHSNKHKLEDLADDKKELKRIAAEEGNARCADCHGGMKASRWATTSLHNTPIVLFLCIRCIGIHRSLGTHISKARSVDMDNWTLEQIALAREWGNIRGNAVWEATRGDEEPRPNGPEEMKEFIKQKYVEGRWLRPEDRPKFGFGPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5M6</accession>
    <name>A0ABR3C5M6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_100731</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617197.1">
        <property type="nucleotide sequence ID" value="XM_066755296.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987589"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="11">
        <location>
            <begin position="96"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="10">
        <location>
            <begin position="160"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="9">
        <location>
            <begin position="280"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0255920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="50811" checksum="44DF0DB1755BA673" modified="2025-10-08" version="1">MSDHPVLRYIPAGAWSLVEPLVSNRAKTLLITLIDFLENDVISSEALYHAQLPADPVTRWQAVPQVLENLKMKAKKLGLWNLWLSGGDFQGMAGGEGGGLTNLEYAIMAEVMGHSIILAPQATNCSAPDTGNMEVLARFGTQEQKNKYLVPLLNGDIRSSFAMTEYGVASSDATNLHNTQATLSSSSTLSLSGHKWWISGAGDPRTSVHIVLAATDPNNSSAYKRHSLLLVEPTQKGVKIVRPMMVMGYDDAPEGHCEVIYDNVQVDLVRGVVGGKEGLGRGFEMLQARLGPGRLHHCMRSLGVASRALDLLLQRVSDPARKTFGKYLREHGTVLADIAHSRAEIDQSRLLVLAAARQIDVAGAKGALQDIGIAKFTVPKMALQVVDRAMQVHGAEGLSQDQPLASWYAQLRTLRFADGPDEVHIQQIGQRELKRVEELQNRTQKIRRESERLLKEGGKERAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5T7</accession>
    <name>A0ABR3C5T7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cerevisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100796</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617262.1">
        <property type="nucleotide sequence ID" value="XM_066755361.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987654"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047168435" description="Cerevisin" evidence="7">
        <location>
            <begin position="19"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="41"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="188"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="54143" checksum="3B1FA8F8D7EFC713" modified="2025-10-08" version="1">MRFTAAVSLLLLPLAALASPIAQPTLAPLEATSGDHIDDAYIIVFKKGVDVNQVALHVGQVQELHAANPLQNSFSDDGEVDEGGLRHVYSPPTESTNFGFFGYAGKFSPSTLDAIRAAPEVAYVEKDQIMTTLEVPRGVDDDVSGEAALAATDITAENGAPWGLARISHRDHLRLSTFQKYIYHSKGGEGVVAYVIDTGINVEHIEFEGRARWGKTIPKNDVDKDGNGHGTHCAGTIGSRKYGVAKQAELVAVKVLGSNGSGTMSDVIAGVLWAAEQAVNDAKKAAHEVATTGRTKHKGSVANMSLGGGKAKTLDDAVNAAVEAGLHFAVAAGNDNKDACNYSPAAAELAVTVGASTLGDERAYFSNYGKCVDVFAPGLNILSTWVGGNSTTNTISGTSMASPHICGLLAYFLSIHGTETFTVIKSESDESLAATAPSIVSMAYAQAYAMLPSLAQAVFPKPELRPVPRPGNGTLTPAELKEALLKLATPAMLSDLPSGSPDLLAYNNATLPKKNATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C8A3</accession>
    <name>A0ABR3C8A3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100506</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616976.1">
        <property type="nucleotide sequence ID" value="XM_066755075.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987364"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="457" mass="50666" checksum="3B561480BF7ED52F" modified="2025-10-08" version="1">MDGTAAGLDAQFNRAVDIVQSLPKAGTIQTTYEDKLLLYSLYKQAIEGDVAIPRPGMLDLLGKAKWDAWNRQKGIDKSQAKRLYVSALVKILRKYADAEDVLKYLQILEHESRSAAPAPPIPSCPGSPASSSSSYHSSQASPALLPQSNNLPTFPQHDMLPLDPSQPPQGIEPNFIPPSSFHSPHRSLSSSMKEQKNGALDAVSRTSKDGSLRDQGPSMAQNLASESHAEMLPDIIPGTESKAASGKPGWIHSPQRQRRDSQASARLASPMPHPTVGSRDFLGTPEAISSPFFGLNQSTPTHSRRPGSSSTFLNSQATSLPYTLQQIQTSLTALHERLSTLERTQALILRRDERRKSWFSWEGQESDELDNFENDHAKEMWGRTGVTTVTKFKAKKKSISIRVLWFLLRTLRRALMDAGVGVVVTFIVIMVLNGGWGRTRWMALKYKERLRRFLTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C952</accession>
    <name>A0ABR3C952_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617291.1">
        <property type="nucleotide sequence ID" value="XM_066755390.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987684"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0256014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="261" mass="28475" checksum="6B3AA4A7589C44D0" modified="2025-10-08" version="1">MASQPSADIRLYKDRASYSLRAALDIFREGKIAHVAFVHPGDEEGEGTKRLRNLLVTIADHVNRTAAINNSGLVEASTRGSGNFTATTTRIDGLVLSPTAHDHSLSYRNATLHLHEPVVLSDETDHEEKRAALAAITNTILGYDRISSVGQPMDANVKSTTVIRCKIAAVSCKQRYGAFNGGKEPVTEVIHGEEGNAFKGVIPCWTQWGDLIGFGNDSEELEELFKIRNEEAKAFAQKLAWAHEDGAIEGLGKKRKPATRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI21</accession>
    <name>A0ABR3BI21_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610739.1">
        <property type="nucleotide sequence ID" value="XM_066761199.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993633"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0240231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="847" mass="93156" checksum="F41B59C000F529CD" modified="2025-10-08" version="1">MPLLFPHFRVHQVFGANTEVGKTLLTTALLRASASRYVSKSEEARKRVFYLKPVSTGPDSESDTSYVQRNTKPYSSYISTHNLYQYREPMSPHLAAQLAPDLPFPKTNEELVRGIEAHANKCLQQLDGQDGCLFVETAGGVHSPALHLPHTQSTFLRSLRLPSVLVASPHLGGISTTVSAYESLLLRGYSLSAVLCLHDSYYRNHTFLEEYFRDRGIGYWTIKPPPEKYGTVEEDGVRLEQWYKEVEKSFEGEQGGGVGAAARWLEEGHKRRIEELGEMPQRTLDSVWWPFTQHQLINKKEDVMVVDSAFGDNFDSYYAKPQSAPSSTNESLLKSYFDGSASWFTQSHGHANEHLTLAAASAAGRYGHVLFPSGTNAPALSLAEKLISTVGEGWASRVFYSDNGSTAMEVGLKMALRAAGRRYGWDGEMGGDVGVIGLRGSYHGDTIGSMDATQASTFNKAVDWYKGRGHWFSPPVVQFVNGAPTVLTTGPDSWSLLPSSIASSSKSTRDGWALEFSSFKDVYDISSRSPSPLATYYRAHIRSTLERLVREGKKFGALVMEPTCLGAGGMVFVDPLFQSCMIEVVRASGDLFAGEKWEGGSFEQELEGLKTRSGAEWQGLPVLYDEVFSGLHRFGYNSAATVLGHTPDISAYAKILTGGLLPMSTTLASPSIFSAFLSPKKVDALLHGHSYTANPIGCAVALEAMKLTTDYEAKGGWQGEKDMWGVEKGAEGRWSFWKKEFVEDISRVEGVKGSMAMGTVFAIELQDDESDYSSHAALDFLTTLRQVVVTPSSSHAAAEDIVPFSPFQIHSRPLGNVVYIITSLWTKPDVMRAMEKVILDKLTKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIB0</accession>
    <name>A0ABR3BIB0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610696.1">
        <property type="nucleotide sequence ID" value="XM_066761156.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993589"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="3">
        <location>
            <begin position="235"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="355" mass="40062" checksum="00E27958190EFC78" modified="2025-10-08" version="1">MSDYEDEYYQDEESEVEYKDDDDERECERYESPPQSPDRSSSNSSSNVSYHGDGSDEDGRYEDLGYRSEHESNDFGNPAAMGIMTGMMGNLMSGGNGVSNRETRGNYHQAPPRQHQNGYSGYQNDYQQAGYNQNMYGQEDYLYQKQDHGGNEYGNGGYCGGYPHPGPPQQYEPTNAGYVPSPAPYAGQQQYYSGYQANKDDNGMPHPQHFGPEFYDRQTGQVAQAYFEYSRCIGRRKALLIGINYIGSDALLAGCINDVHNVQKFITERYGYQLDNIVMLTDDVNDARTMPTRDNVIKAMKWLVDGAQRDDALFFHYSGHGTQRKDINGDEQDGQDEAICPVDYETAGLLIDDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ12</accession>
    <name>A0ABR3BJ12_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611182.1">
        <property type="nucleotide sequence ID" value="XM_066760910.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993337"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="76" mass="8706" checksum="275AA4B29E754C8B" modified="2025-10-08" version="1">MVWTSRKTLTAQIHESRVEERFSSSTCVLQMKRHSRPPASTLISVTSHYAVPAVTVLASWWKRLLSRIQKGGGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ13</accession>
    <name>A0ABR3BJ13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611177.1">
        <property type="nucleotide sequence ID" value="XM_066760905.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993332"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="93" mass="10400" checksum="598AF6667DBE3F0D" modified="2025-10-08" version="1">MFAARSLLRSSTMRVGRNMMARKISTAAPAPVGPIRAFFQDVPIPVDVYPLVGIVVVMCSGATYMLNKHIYEDRDHLRWAPQRGDVKFLLPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJU0</accession>
    <name>A0ABR3BJU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106176</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611384.1">
        <property type="nucleotide sequence ID" value="XM_066760623.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993031"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF218">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046617267" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="703"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="821"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0242002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="864" mass="92010" checksum="C84B75D52007C675" modified="2025-10-08" version="1">MPALLPLLPLLSLVLPQVSAGARSSSLPHNLHHPYRRSLKRSITSDASSINGESFDFVIAGGGVAGLTLAARLSEWSNVTVLCIEAGGDGSNYEDQIDIPGYSYLHSLTGTAYDWAYNTVPQADALDLTKYWPRGKGLGGSGAINGLFWGRASSVEYDAWATLNPNGNETWDWQEVDKYIKKAENLTAPSADFQEKFGMVVNTSAHGDSGPIQIGFSEYIFDEVAKWIPAWQTLGLSGKDLAGGSTHGAMISTSTINMQNQTRSDSKAGYIDPLPPRSNLVILTNQQVTSVIFNGSTDASGNIIASGVTFQADASSTSYSVQANKEVLLAGGVIGSPQILQLSGIGPKSLLSNLAIDTKIDLPVGYNLQDHVSYSMYWSTPQGTFTWNNLSVSSTLQSEQLTQYKSNFTGMWTYVNEAVGYPSMSDIMQSSTSASSYASTVSSAIDALVTNVTSWLNLPDNVAMGLKSQYQIQQEWLNEEIGQLEIVLTLLGNGGNEIGIQVALQHPFSRGTIFINSTDPFIQPNINPDYFGVGYDIDIMGYGSDFARRLAAASPLSEVLITETAPGPTVTGDSLATYTKQKCGTEYHPLGTCSMLPKDSGGVVDTTLTVYGTSNLRVVDVSIAPLQLSAHLMATTYGIAEKGADIIKKKYWYVEPVTSSTATTATASEPTTAAIGDATDTAVTNINQNNAESGSTLSSGAKIGIGVGVGVGAAAILAGLLLFFLMRKRNQKQDEKGWYNDRQAGWNPDAAGAYKEPGPAYPMADFDSHDSYASPTPAFIGNHSRNQSINTIATADLASRTPIRNSSSFSYAAGGLDVGRAASPYRDDMSEDGNGQGHVYQGPGAPAGPQATRAQQRYHPVNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKG3</accession>
    <name>A0ABR3BKG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase assembly protein subunit 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105907</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611660.1">
        <property type="nucleotide sequence ID" value="XM_066760356.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992762"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0242278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9380" checksum="9DFD7667123638A8" modified="2025-10-08" version="1">MASLVANSSEISSPATALPRSTSSSPDAAVKEMNPLNPNNLKPCCACPETKQARDDCFIKSAPGEGETNCREFIEAHKACMRGYGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKP3</accession>
    <name>A0ABR3BKP3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611368.1">
        <property type="nucleotide sequence ID" value="XM_066760607.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993015"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="692"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0241986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="816" mass="91578" checksum="14B5826C88D6C599" modified="2025-10-08" version="1">MTQQPPPSGSDIDLDISLPFDSQDSPGVTSPLPPARSSFINNYDEFEIEEDFDGEELGKAMDEAERRYRAQIESSMRHVDGRAMLKPLKPPFKVGDIEDIVPDQIESSPLPSQSTVTPLVFAKDAEQIQSQELKKDGEAEISLAPFFQFRKRGFFNVTDLAAPVWCETQYNYRLRTLPFLPLAERPDVITTTSGKQIAVDKGIREGGERIMNRGRKVHKRLEREIHPDEVVVSTTTREDVWGLKFLNMLSAVEALLTIGKCREMPVVGFVNDIMVLGIIDEIVRSPIEPSKLKASKSITPSKSPNDTSRQTSLANFFTSTKPSQVAGQIPSVNLPLTSLSQQSKPRTHKLYISDSKTRSVLSVPREEDTKAGKIQVMMYKEMLDAILLAPYQSSTPSTDQQPLHDPLSILPSRTSEPFAWKKIFDHLSLSPTEPFSEQFFKESRIVIKGNKLRHGANNALCLQDFVHVWEKYVEDLGLGYNRESKLSGVREEGEEWENLGRTEDKLELVYRWAGGKKRGNRREAGKRRKRGFDRESTNEREDSLDVELQGEETSPNRTHGPLETAEEQCLIQLAIAESLSINPAAAPITPYLTTPILTPSYTLPVLHASPTSVSKRHKNDRAEGTAHEDEEHWTTTDDEFYAHAIENGLGEEHASGERFLSGSVDIVSDKAATTSPITPAFKVLPTRTPPNLESFNFQSPLAPSTPSKGSNNVHIPQPFSPTSQEETRTKAKSKGGLVAGSIIGHTVFSHSPKFLAKHLESVLQFWMGERPPKGVEIHEAKRCAYCEFEDGCEWRLMKVEEHRRQIEERRKKYDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKT8</accession>
    <name>A0ABR3BKT8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611771.1">
        <property type="nucleotide sequence ID" value="XM_066759825.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992224"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF26">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DDB_G0283821-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="762"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1042"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1397"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="616"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1406"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1452" mass="159273" checksum="92184FA2AC8DA878" modified="2025-10-08" version="1">MTATALSNYQLGDLLGRGASGNVYRALNFLTGETVAIKSISLLSLPPSSLPDIMSEIDLLKNLNHTNIVKYKGFARDKENLWIILEYCENGSLQTILKKFGKFPESLVAVYIRQVLEGLIYLHEQGVIHRDIKGANILTNKDGSVKLADFGVSSRAPTAILDQSDKSNDGGAEVVGSPYWMAPEVIEQSGASTASDIWSVGCVVVELLEGKPPYGDLAPMQALWRIVQDESMRIPEGASPIVKDFLYHCFQKDPNLRISAKKLLRHPWMLSIKKSSSNQSPVTPSLANINPDQNNIDSKASSTGTIPKAQGDGDRSRFESESEDEKQLRQGTIKPRKEKMTVYDEAVQRVQEWNEALQATPKSPSQPLPLPFPFPSTSSASASKALPLPVRSTNPSIPKTRQRGDSNQPLSLFSLPPVSKSKHSSSSLPQEQSMLLPLQLQNQVGQSGGLLSKNIMVSNVLERAREEGEETWDDDFAEGISFSKFGRNEMHDHPQVRLHIHATSSALYSPTAREEVDAADQKTVRQNRALALPAPSSKPKPKLNLSRPVGEVEDYSDMEQAFGENEGSLEKKLRILKLKAIGRTGLMHPDDIHKYPLSPIKPTAPSRVGVRGHQRTISTSTTIASTTSASASHPRAPLTSTLLSSSIPLPSLSPPTKRSSSNPIPSSSNTLTVPSLSGTGLEAEKERGDNSPLSQGAPNRSSPSFRSKSLRSKARIGEEVEEQIKKYTEDEDEDYDDIFGGANKACSSLQVPFKLSLLPPHSLSSSSTLRDVAGGGGGRGAGAEGGSISFSDRQFNYPNFDYPDSDEEDMSDPFAEIEDEFDTAEDLEKKLMRDKKVMMQGKVGKLVDELMIGGAAAGGLRMVCDDLLDILGNSPPEMGLEAHFVAQHGLIAVLEVLESRLRRDVIVRLLKLVNLIVTSDVELLESFCLIGGIPVIIPYTSKKHSLETRLEASTFIRQLTRSALTLQMFISCRGLRILVELLDEDYALNKTLILSSLEGISSVFELQSPTPRNDFVRMFVREGVIDPLSTALLAILKDKDENRGANENENGNGNGEMEERQGQEQGQSMMEQASRAVGVLLFFCQVAQADARVREAFATRTVMMRLLKACDLLPRKLLVTAIKSIKHLSTSPQLIEVLQNSNAMEILVDLLGKSIKGSHSNEICSNIFQTIYSMTRLSKSRQEEAASSGIIPLLKRVIQSKSPLKQFALPILCDMANAGKGSRRLLWQNDGLGLYLDLLEDPYWRVSALDAISAWMQDETARVEDDLLEKFASDSLVRCFVQASGVSFEGILDPLLKILRLSTSLTSSLSHPPFFSRLSESLERSTKAVIKLNLLRLTKVVCECHPDKATLVERFGLAEIVERLSRQDGAVLVRELAKEILPGLLFGGDARDPAASSWYTSSSTAGEEKVGRMRKSEGRKEGKRSSQLRRTLSENVATDALHPIVTVQPYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL16</accession>
    <name>A0ABR3BL16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611686.1">
        <property type="nucleotide sequence ID" value="XM_066760382.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992788"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0242304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="55016" checksum="19D4B229D5C5B739" modified="2025-10-08" version="1">MSVVPKCDETGCTENAIRVNSRCRFCKLNFCWSHSENETSHPCLTASHPETNRDGFEFEKDPEVSEILRYLDVHAIKQEVESIFPGHVCNYVGKPQIWQELPRLCGNYNYHIVLGFADGQRWAMRIRLKQRKYLPPEALIASLNSEIATARALEDAGCAVPRTWERPKDSQLSEQLTYFYQEFVPQGDCAIYTLWTEPFNQQTKVFIRNHAKFMIGLEKVHFNQIGSLTLTENGSVTVGPFIEKRTTIDTPPYFLGPFNTAKEAYLAIIDVRLQQTLNKSRYKPSRELLHYLVLLEVRWLVSTCAELDNGPWYIRHNEEDTNCIRVTNGGAITGIIDWKWATLTSKGGAFAAPFCFPDDKYSEGLNALGVRELALIEAYRNLGRPELADLVRTGRKYHRLFDVLFRECVTLTTLNALRRAFLGLPDGRQGLPQTLKEWIQVAKQNFSTDEHLEEMLERSEEFVKNSNQSAMYSEHWGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLJ1</accession>
    <name>A0ABR3BLJ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611653.1">
        <property type="nucleotide sequence ID" value="XM_066760349.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992755"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="209"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0242271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="289" mass="31530" checksum="EC604D072B2DF3E9" modified="2025-10-08" version="1">MSTLATANLSSDESDTEFIPEAAKSKRSRKPRAKRIGSGSASDSSSCSSSSASEGENAEGDERAAKKAKLEEDAKNEAEERRRKAREEFERMKAEPSGAPTESVKETEELVEIKRPRRFAGETIYETVRLRASDPEAVAYLNRLAAKPGHDEDKSDSATKQPLPQQETPTPVPSAPSGQDKSTTDAKADVSVATSVVAPSVAARPKGPPRRKRQTLEQMSAALDKGKKMTTLEKSQMDWKSHTSSSASMEDELAANRRNGGFLEKKDFLDRVGERRAGAFNEQASTRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLJ9</accession>
    <name>A0ABR3BLJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611866.1">
        <property type="nucleotide sequence ID" value="XM_066759920.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992320"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF5">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="113"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="257"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0243499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="434" mass="46010" checksum="CFA2E004AE1622B9" modified="2025-10-08" version="1">MAAPFVQYGITPGQSAEAPKRPHLYVGNLSPRVTDYILTEIFAVAGPVVSAKIIQDRNFQHGGFNYGFVEYADMRSAEQALTTLNGRKIFDAEIRVNWAYQGNQNKEDTQHHYHVFVGDLSPEVNDDVLSKAFGAFGSLSEARVMWDMNSGKSRGYGFLSFRDKADAEQAIASMNGEWLGSRAIRVNWANQKTQTGGSRTGGGTPSYSAPPMGAPPVPAGVPSAYGAAAPGVVPGVGVGGAVGSFETVASQTPEFNTTVYVGNLIPYTTQADLIPLFQGYGYIVEIRMQADRGFAFVKLDTHQNAALAITHLQNQLVHGRPIKCSWGKDKGSMEGGAPAAGYPPMQPQLGYPNYNYYGGYNYNQAGVPGQPGQPGVAVASHAAPAVGAVGAVGAEGQAQQGAWDPAAAAAYYQAGGWGGYYTQQQDAQQPSAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLX6</accession>
    <name>A0ABR3BLX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105429</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611830.1">
        <property type="nucleotide sequence ID" value="XM_066759884.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992284"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="10">
        <location>
            <begin position="223"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="574"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="498"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="574"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="669"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0243463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="715" mass="79452" checksum="CAE59190E40C7A7E" modified="2025-10-08" version="1">MGKGKNHDRKANPGFGRVKSKSGTSSGEFTLKRVKGENFYRDAKSAARVKMLNGGKAVRDRDGKIVEAAAFQKGEKEAEPGRVKPDRRWFGNTRVISQSALDHFRTALKEQKADPYSVLLKRNKLPMGLLQDDTKDSGGRPHIVETEPFGDTFGPKAQRKRPRLDIGSIEELGESSAAAAAAAEAATAESQANGTADLADVYHPTTSTAREPIYAKGTSRRIWGELYKVLDSSDVVIHVLDARDPLGTRCKPVVEYLRKEKAHKHLVYVLNKVDLVPTWVTARWVKHLSLSAPTIAFHASINNSFGKGSLIQLLRQFSVLHSDKKQISVGFIGYPNTGKSSIINTLKKKKVCTVAPIPGETKVWQYITLMRRIYLIDCPGIVPVSAKDSDTDTVLKGVVRVENLATPAEHIPALLERVRPEYLERTYGLEHVDGGWHGEQGATVILTAIAKKSGKLLKGGEPDQEAAAKMVLNDWIRGKVPFFVAPPVKSELESQPGAPAATATAVEAEKKKTEAEEQELAEERETMEMLEEQERSLGMVLGIKRVKGVEQPISKIVTMTKFIGDDARRYVEEEVVDEDKEMAEEEEEEEDEEVEEDEEDEEEELAWEDVFPEEADAVDGGEEEESDEETDNEDVDEEEAVPSAKQLGKRKAIDSDEEETATKSKRMTTSKQKATNFYTHANVKNRNRDRKVPKNPGKRSRGDDETTGKKAKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM81</accession>
    <name>A0ABR3BM81_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611058.1">
        <property type="nucleotide sequence ID" value="XM_066760786.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993210"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046067242" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="225" mass="22511" checksum="2215A300A71A2FA7" modified="2025-10-08" version="1">MIFTNTVAYLLSAALAVNSVAAGIYITSPVAGTAATGGQVLNVAWQDDGKTPTLGSIGACTVDIYTGSTNKQIFLQNLAASVDVSKASSISATINPSIGQDDSHYFVRFTSLPLKDETNSQYPYEAFSAMFHIQSMTGTFNATVLAAIDAANSSSSSVITSASSTATSGGASTSGAGFAASNTKSATHSASASSSSGSSTSAAFHQAAPATLALALIGAASYFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM87</accession>
    <name>A0ABR3BM87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612276.1">
        <property type="nucleotide sequence ID" value="XM_066759629.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992028"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF122">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045791196" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="75"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="275"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0243909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="497" mass="56276" checksum="1FF2505811C04FD5" modified="2025-10-08" version="1">MVHLSTLFLLPLAFAAPAKKAARDIPELSVSQWASIQESFGDKIGDFAAWSWNKAENIVGDFGAPKDAGDDKTELTIWQRLKEDPHSFSRLVKIIEFEGKAIEYLDDKDLQITFFAPNNDALKPPHHHHHHHHHHHHDDDDNALDALEQAPSLAAISDVIEREPALINGDDDNDDDDEEKKRKKEILRKIIGKVLAYHGLPKAYSVQQLSQNSTVETTLKAEDGSYAGLHRRVRIEKCLVPPSIKLNFYAKIVAADRKCGNGYLHALDHPLIPPASILDELFLFPDSFSTLTSSVQKIHMAHALDFCIEHDEDYKHKVHGTPLATLFAPTNTAFALLPPKLKFFLFSPFGKKALTKLLAYHYVPHTLLLSEALHVEKHDHKDEFIEQFTLADGDDPSFHKEFKIETGLPNATLSIEIDKTKLFPVEGAVKTRIKVNGQTVKIIDVPSRNGAFHIISKLLVPPHKHHHHHHHHHDKELSGDNSWENWEQWLPQWANEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMR3</accession>
    <name>A0ABR3BMR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612440.1">
        <property type="nucleotide sequence ID" value="XM_066759793.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992192"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="281"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1284"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0244073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1352" mass="147462" checksum="1AE07C1FD0990F34" modified="2025-10-08" version="1">MSILQRRIPSLGGDPQLATWQQLFRHTDRVIAAHPCRVRAHYNPFRHASALLVVTSAQPTEAAAVFIVAAPEDGKQPEILYTIPIIPTFKHNLEQTPPSPSTSFFHQSAKPHITLYLSCDDAAIELRIAANQSAKVQKFVTELRKYSDLANNTLYPSSLTHAWIDLYPVNSPDDENADAADESAVDPSKVIVVDHQEKTENTPIVTPSASHATLTPTTPLSETSSLSTPIPTSKSPKHEVNTTTSKQAEDPQPNPYLPTFSRTSFLRSRLFSSLPSWSSSIPIKIRTVSYNVNDKVPPKGTLELKGLVGGDDEEASDLIVVGLQEADLRSQALLISQGNSRADSWEVALFAGLGDKAGEYEKLVMTQYVGVVMIILVRKTLRPNISRVESSERGIGLLGFGGNKAGVAVRLKVHDTTLCFVNCHMAAFTSALDRRRQDYQILRSGLTFPRPLSSASLTSAPLSSSSAASISILPISSASSASSGTHASAVGTGTAAGAGAGTMSTSGTREEKTKSEGEEETINPVFEEFWPEVKDKLLTLEDCHLLIWMGDLNFRVDLPDGEVRKLVENKDWAGMLIRDQLKNDIKEGKSFVGFEEAEITFPPTFKYVHGSSTLDTKRSPAYTDRILYSFPCPTSTSPTPLSPCVPVSINKEKYTSHEELKWSDHRPVSCVFEVGVRKVDVEKRREGSRRAQKELDRLEEVWRPSLEIKVLPEPGDANADEKEEAQEEDEGGIHFGKVRCREKKERRVRLKNGGKVPVSWNFRQAGIGRDICKPFLWPFPSSGTVEPDGEMVLTIVLDVNEEWAAKLSLGEEDGNDVLVLQVEGGKDTFITVQSIFLPSIISLPLTFLSALPSPIRHLSLSERKSLFRSLLETAEKQPAASDENENDNEAAISIPTPFKPVKEIWTLLEYLMANPPSLSTWCRPSLYTSSFSSSASSAGIQTIMEHLNTLPSTTPLPPDVPHLIPPTLIYLLSSIPGGLLPESVQEQIEQKGVEDRDAAFGVLEGVKMVNTNTLIGMISVVRLCLGDGVGAQQGGAKIEEDANGREHVVEGGRKVEEPNPNSSISKGGINSTFNVVIPSTPESNTKASRNSADLSTSHSNAENNANLESVLESRDDTANLEPEGGALFELGDDEDDDDEGEVKEDAEDEDVVKDGDENQEERDSVPEIEKESKDASDAVKKDAEEEKNDAEEKKKDVKTKDEPTSSFDASIPITEPKTEPSLQPAAELTPSKPRPKTKRAKSLAEEFLGEASLIENDVSIDDTDSRTSGKVKIGDVTMDKVEKVDGETLETPKAPSRLPAGTGGANAATKKEEACTIDKLVDVLCPAVFGRVHVSAVGRERRRKFIKLLLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMX2</accession>
    <name>A0ABR3BMX2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nuclear pore complex protein Nup133</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104518</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612479.1">
        <property type="nucleotide sequence ID" value="XM_066758992.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991374"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="87"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="853"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1214"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1232"/>
            <end position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0245395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1244" mass="138377" checksum="018019EAA9498657" modified="2025-10-08" version="1">MFSSPATRRTQTPRRQQPQQPLSRLQAFRTTDHSPAPSIAETIRTERPVNEKEKVFWSKDERHSVTSLGKLPGEAAALIKASDLVVDPVTAQIDGTTGFAILSSARACIAWNYSKRTHSAPTTYAFPAPLPTSSPSRSPPPVLSALCTSTPEPGMILVSSTGEFRYWESMSLTLSNVERYQQLFLDLPQGDWIERLVKVDGNNFILTTTSSQAYRLSITSSAGMLSPVVAPLMRPGGMFGRASPLIFGAKHDRFGIRSVTSNGADVYLMAQKSVQKWSFTNDGQKLVQEYDVYEAIGRELFDEWSSANITIILEDIVTLDSDSLAVLITYSDATSPSSHALVLLSVHRSNPPIIDRTIPISFTSGQDQRMLDIPKLVIPTGSTMAFVRFGSAVVMLSLDFDIPYEETLTLKDPNNIYIGAGPVTNSSNIPCVVLIPAEGGLMNVEALEPRASPDSPNRLSTATARLKSKMEQAIFFGQRSDNPLSFELEEDVRGQGDVAEAAELVSGEVVAARSPYTPTIYELRPQLLDRLELLKALVKYIRANGLISQLPQATRRRLSGDGEKVRGALELWDYQNRLMDQSSGQVPSQAKTLLSTSIQVYFSSRHHSLAPSSSHSDELEQDLVRLFFRTEVSNLDKLLAVVFEEFREKQGEGVEVGGRAGWVGEVNQIFIAVERAAAQYREEESDLYAIDREKPAIEMWTASDNLIDSLDHLYTLTEALIKERTRELGSVIDEAPVTGGPTGRIETGKEELRKEQVVQAMLKRQMGWLAAALCTNMEDKCRVVVRRQMDDGADEQEGIMLKAKWDAMKPRIIRPLVSVDRISEAYELAEHHHDFPTLVILCNDPVAGQGKGDSRIQVYIEKFGEDFAFELYRWYIDQGQLHALLTQDEVYGSLVTRFFDTHHYPELGWIHNIACKQYGEAADALAQVLDEGEGKEENGALDFRKAVGSIAKLASMTDISLRGPSEARDQTFQKIGRQLSLIDIQISLRTYLLSLFPSTARSSRSISKHLAPILTRLSHRPGPESGSAFLALFYNLAERVIDGEAVDLEGMLDLLTLKDNIGREDDGVDALRVLVLDRSLPKARSEVALLAVWRRIYIRDDWAEVSNTAGRSEQAQRTKLKETMIYRVSKALRSVPEFPQAAIISPYDTSIPPTTIELSARFPTLTSEGIAALKADYDDEVAMLMEYVEKNGLEERVKEIKRMIEREWEEVQGGEIDEARGAQPESEVVVVEAEDVETDEDVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN81</accession>
    <name>A0ABR3BN81_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104653</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612605.1">
        <property type="nucleotide sequence ID" value="XM_066759118.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991509"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1314"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="422"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="542"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="664"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="705"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1621"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1686"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="554"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="787"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="820"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="866"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="936"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1025"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1147"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1622"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1636"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1647"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1702"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1720" mass="184268" checksum="4DAB6E505DB1EC82" modified="2025-10-08" version="1">MSSLGSHTPSAHTAPSPVSPTAQFTPRHLPKCEFPSPPHPPAHQLPHPTNVPPPSDQRGLLPSSSSIASMSSSPRGRRAPAPAALDLGARTDRSKYADVGLGLGSHRMSRPLPHPPGQPGHEAWDNVYQLPRDASYSSTAQPHPADIDRRNLVGVGELSTPRWPGSGSGVQSDIGRPSSHLPPLPPTATNPQEDHPAMNEARPRSISAARTPPRPAPTNTRETLTVPNTAAHDGQLYSVASLAQFNFDSTMEGSLAASLATLSTPPKTNSPKSPVISQIDSILPPSPGSARSRIYARRQERANAAASISQHPSQPIQSFSQPPAPQPSPSRPQPFAESQTLSQRTGRDVRKTPPNATSSRHSTSHDILKQFAVKDFSHLPPSPSSASINQFLRSSGSTQNISSGTPPGSASASGAYFLSKGVQREDSQNSQKHQQRTTPKPKELDPNVDEALRKLDGLTSTPGKNKARGKSSGGPSAASSRPGTPVAVAVAVAVAVAIPESRSSRSESKIPLKPSIGSFKDTTGSPLNNWIDLTEDIPAIPIPRARIPPHPNRESSSSASATGTPNSHESQSLPTTATTMSSADLAASNKPPPPRRPSGGSETSAQGGMNADHQPEGMEKSVPPVPPLPQVYVNKKQQGMPSAMQSGGVQPPSYVLMRELSPEPLISSPSKSTSPVTTATTAPVPVPPKMHKKWSFSSALNLKSAVSPVSSVDEMALSQSPQTPWSEIHRGELFSPNVHVQGQGQGQEPRGDSGPRQGATPLAPPPPSSSASSSKASSSNVNKRLTPSSIPFFRRSSSSSFHKTNQSVVVPETPKQVDKTTATTAAATTTTTTTAAAIPSSQSRKSVLGMHFPSMLRGSSSKRGLAQQATQQQAGQSQVPVKEKEEIKAASAPSATSGWTGRKRGKTLSISGDLPKPFPGLKHQSSAEISFGTRGSAVSNGSDATISSSNTYDRLPAIKGSPARPPPPDGPRYSNSPRNLPSATPTKIPRMAQRPAPSPATVTAHSGMPPPPFPTAKKISNTVSGAGGGGGGGPAVSEFGLVDGIIPTTPRLTTSGAHRAHLLAPMSARHDTRRVNNRTFDPPVRKDTSYTSGVPPSRRQLPQPPTSTTVTSMTLSASAKRASREFKKKRESKDPQDGGWSSSGKNSPVKPSKSMHSSMVVPSSSRLPSSSSAGAPGSNYRSRLSLADDSSPSMSPADDDEASGDAEMEAYIKRRRERAAVNKKDNLSDVTEFPRDITPVEQPLSQRAFITNNLAKMSDAERKEVLDFDHIYYSPSPGTIRRPSQPGGATYNHGYDDERGDYLVVEGDHLCYRYEVVGILGKGSFGQVVQCRDHKTGKSVAVKIIRNKKRFHAQALVEVKILQQLVEWDPEDKHFMVRMTDSFSFRNHLCIVTELLSINLYELIKANHFAGFSTVLIRRFTTQMLGSLQLMRSHRIVHCDLKPENILLCHPAKSAIKVIDFGSSCLETEKVYTYIQSRFYRSPEVILGMNYAMAIDMWSLGCILAELYTGVPIFPGENEHEQLACIMEVLGVPDRYLIEKASRRKNFFDATGAPRPFVNAKGRRRRPGSKTLAGVLKCDDELFVDFIARCLTWDPDKRLKPQPAMRHPWILAGRKRYALTPSRDEKRAASERSSRLFGSSHTSTRISSKNLSELSSPSIKDKDKSKLLISSPVPLAPARHAYHSSIASTSRIGQAMSPSRLAHQTSARSGPFNTSELSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNB7</accession>
    <name>A0ABR3BNB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612642.1">
        <property type="nucleotide sequence ID" value="XM_066759155.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991546"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="1">
        <location>
            <begin position="431"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="534" mass="57782" checksum="DBF1F78242A2B8DB" modified="2025-10-08" version="1">MRIPLDVAHSVVRALHTIRADSAAGNVTQASVHVPNSQPAWAQPLSPNLAAISIEMDRWQDWAGQKVGQPNQYVNQVLTNLGERTGAMPYLRVGADSQDRATIDLSFEVMNATFPTPTAEVPIPEAAHISIGRDFYALSGNLPDGTTFQWGVNLASLNRTETVAQAALIAEVFQGDRASLTANVRLDGLEIGNEPDFFTTGKPGFDATWTPVNYTQTWVDYARGVSEVIQLGGDGPYLTPCAFTDFAAPAWIPQAAIEAGLLYDDDIRAVIKQINAHVYSGAFGMGYPLSPVGGLMDKATVRTNLTMRANEVTAAKSEGLQYVFSEGNSYANHGQPGTSNTAESAIWGVDWMLQLASMGVERMHFHHGVGYRYNFFQPVAADADFNDGLNLTSRAHILPLYHAALIVNEAIGTNNNSYVAEISTANDNVVAYGIWEGKELVRMVVANNEVYTTDDEAAQKGRNMFEVNLVGVEGRNATVKRLFVPQTTAMRGITWAGQSFDTEDGKPTGQVTQESLNNGVLEINASSVALISFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNM0</accession>
    <name>A0ABR3BNM0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydroxy-acid dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611583.1">
        <property type="nucleotide sequence ID" value="XM_066760279.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992685"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="3">
        <location>
            <begin position="115"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="4">
        <location>
            <begin position="366"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="4">
        <location>
            <begin position="449"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0242201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="55982" checksum="04FFC92076F586CA" modified="2025-10-08" version="1">MLARRIAIATPATHARAFHASATKASKEVIMNRYSRTITQPKAQGASQKALRMTKTLTKLWLALPVFGTKATRESTSIGARLTFQMQSTHLGPWSEGEEVSYERWHHWLPIWYLSYSLQSRDLIADSVETAAGGHWLDGMVVLPGCDKNMPGTLIALGRLNRPSMMVYGGTIRPGSCNGEVLDIVSAFQSYGRYLQEGQTPEAEKTRYNTIRNACPGPGACGGMYTANTIASASEALGMTLPGSSSFPAEYPEKHAECDAALTMALGGSTNVVLHLIAIARSVGINLTIDDFQAVSDRVPLLADLKPSGKYVMEDINTIGGTPSVIHYLIKNGLMTGDEMTITGKTLGENCDRWVEKHGSKWEGQKILRPLNDPLKSTGHIRILRGNLAPGGAVSKITGKEGLRFTGKCRAFDDEESFVKAVESGSIKKGEKTVVVLRYLGPKGGPAEEAQVGGPIALVQDGDIIHIDAVGNTLSVDVSDEEMARRKESWVAPPLKVTSGTLLKYARAVTDASHGCVTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNV2</accession>
    <name>A0ABR3BNV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612836.1">
        <property type="nucleotide sequence ID" value="XM_066759349.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991744"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="118" mass="13242" checksum="24786B744A44B76B" modified="2025-10-08" version="1">MTRLRRLSDLALRCRSSSQVSLNDRAPATSSFGARINTQKRAPETRNVLRKKNSIRRKNVPNMYNAAGNPAGNGQNKIESRTRFVPSRGQVQGSDCTADFVQGDQHLRMMNAERSRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPF7</accession>
    <name>A0ABR3BPF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiotic nuclear division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MND1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612489.1">
        <property type="nucleotide sequence ID" value="XM_066759002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991385"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="6">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Mnd1 HTH" evidence="6">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR026991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0245405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="224" mass="24870" checksum="1344D2033EA7D925" modified="2025-10-08" version="1">MSKRGLSIEEKKTKMLEIFHESAEFYSLKELEKIAPSESFLPSSFLPPRLKLWCNSESKGIVVQSVKDVLDDLVSDGFVFMDKIGTGNYFWALPSAAGVTKNAALAKATKELERIEAGISETRAGLMEAEKGREDTEERLTLLATLQQEEQTSVKLKAELAAFGAADPVRYQKKSEAVKVCKDAAARWTDNTLMLLQYTVSLGVEAQAIRGMLGITEEWEDLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPK4</accession>
    <name>A0ABR3BPK4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA repair protein RAD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611913.1">
        <property type="nucleotide sequence ID" value="XM_066759967.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992367"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="541"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="1197"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="480"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="678"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="753"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="753"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1359" mass="150452" checksum="DE3E6D2782194672" modified="2025-10-08" version="1">MASINGVSSSPVASTANGNRLQPHTSNDTSIQPPSLRSLESIDLTGDDSSGDEVVESPRHGGSSIIRSPKTSGSLFTSAHNARPAKDDSSSASLHAPSSRRLPFTIDQRPSAFSNDGITYAGSSTKSPSASASFGTMPAGPNPAGFGQYASQPSVSGWTSGESSSNYPNGNDSTGAFYVNGTDASSAIDLTNRNIPSPPSIDEKKPLCIGSLRSNALMLYPCPAVVVGAQPPPGSKERYDLVVYRGVEFVKVKLKYRGAGTLARKDDPNSVLQRDTIQVLTPSLTTYVGDLDSRVAVHLANLMSRGLCRLEGFVPRLHPDAPQFQVRVDVLVFTLPSNVQYIANFLAGYNLFLLDPIPPYDPSRHSDHPPYQNGHGSGEAAMQLLAYAQRRIMGASGNTGSEFVFSDKEREKATQIEVQRKQVDEVFKSLDNGTELEQSDPGPLIKTDLFPHQRKALTFFLTREQDSSCLKQCKKTAKKALRKKRGHTADAEAEEEKTKEKEKKKDEEDGGNSLWEPVKDDKGKIRSWKNKITGEDLRGKKGKPAESKGALLADDMGLGKTLSVVSLIAATRSSARKYARTKLESLTSTNETSDEESDIKAGDFKTRIFGMPSVDEQIAADTANKKRKRDEDPVKNLSARRSRITTRSKATLLITPMSTIANWEDQIKEHWNGPVEIVGGASGVMPPKKIERKWKPPKGKGQESSDDDDLENFDLLRIYIYHGPSRRPDPKFISEFDVVITSYNTLANEFSKQNGTYDTESNTPGETANNSGDEGTESKKIIDSEIKPAEVAALIKGGKKGKGKVKTGDQTSPLQAIDWFRVVLDEAHYIKTASTVASQAACYLEADRRVALSGTPIQNKIEDVWALFKFLRISPVDDKDIFTSYISSPCKYGEQIGIARLQLVMRCCTLRRTKESTHEDGSKILNLPPRSERQMWLTLREDERKIYDERANKAKDKFGELKANNEVSKMYVNMLQEVLRLRQICNHVDLAMEGPVEEDYDGTVMDYEVAIQGIERNGLTQPRAVAVVCSMKEGEGATCTSCGLDFGDWFPWVGLGGVEEEKEKPKMKKMPTKPLLTKCLHLYCLVCFKAQIYPEYSKRMKGTLARSCHCCNTMIRLPSDVIEVIPPDSADASEQAVAEQAPLKRAVRKKYIRPPGEKLNLSTKMQFLHDELLRFSKKNPHSAHYDPFSLEGDDVEEMDAEGKPIVTKSIVFSQWTTMLDRIADMLDETNIRYARLDGTMTRDERSKAIDALRHKKNVEILLVSTRAGGVGLNLTVASRCYLVDPYWNPSVESQAIDRIHRMGQTRPVVAIKLMIKDSIEEKLDKIQKKKAELAQLSLKNMSRKELMAQKSEELASLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPU3</accession>
    <name>A0ABR3BPU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DIS3-like exonuclease 2</fullName>
            <ecNumber evidence="4">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNR ribonuclease family. DIS3L2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613178.1">
        <property type="nucleotide sequence ID" value="XM_066758730.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991108"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03045">
        <property type="entry name" value="DIS3L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028591">
        <property type="entry name" value="DIS3L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNB" evidence="6">
        <location>
            <begin position="1094"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="607"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="689"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="958"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="962"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="1106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="1115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1650" mass="178927" checksum="C4DBEE49168E86ED" modified="2025-10-08" version="1">MADPVSPTPDHQSQATLAPPPVNPSRPSSANSQKSNSSRGRGKNGSRGSSNMSRTNSNTSGQSDSGRSDKKRQSGPTTTISGGVSLGVSGEAPQQGKKGKGKGKNQDKEKEGEKKDPSMGVEKPQKNNSQKGKRSASGRRPQPIGTSESPRTVSRNSEGVSMSADAGTSQSAPGPKSIHAAVSAPRTAIEAAVEAATEKHRLQTGGDALASLQKMISDLKTLPPTSGPGSGSSAGSRSTSVTRDRPTSSSAKTEPVAIPSASNSGSHKTLKADAPTFTPSFQSFSPVASTSGLSVSPTNTMPTLAQSHPRSQSQSNGAHPRRNSASSMSSVNFAPPFNPSPIQAFGNPLPPFYQTPLSVHAEADDESLSPLSFAQHASFQYQQQQLLAAQQQQYQYIQLLQAQLAASQLAHQQAQQAAQHQNQQMGNFIAPRFQALAAQRAASLQQQQAAQLAQAQQVFELQQAQLLQQQEEARTSIHAAVEAAHPQNQPVFEEESPELQPRTVGPSGRPQLAPSFTFGARPKHGATESVSERGSGRESLSPPQSSLSPIVVNRSEGIGGAAATGLAGLAARAHKRTGSEMSSVLQQQDLAQQGDSPLAQLNTAYAQKPTPSQNVSRHRRVQSSLPSASVPVDFEREQDQPRSMKSVSEMPPPSLPSGHGRRHSVNVLNKTAGSGMGFGLADDIPEGVVAPSGHHRSGSRSGLESGSWRLGASSSNAQSSQSQVADLAAAQAQLQSLAQFRAAAGGGHSKMASFSFPNMLPNLLAATTLQAPVGQSLWQQQQAFQMQLQQTTQGPQRKSLFAPYLPQASLPPLLQAGKLVVGVLRVNKKNRSDAYVATDVLDADIYICGSKDRNRALEGDIVAVELLDVDEVWSTKKDKEEKKRKKEENATYDLKPSTLKKLEKKKDDVEVEGQGLTLFDDEEVNDDTKPTYAGHVVAVVERMPGQLFSGQLGVLRPSSAATKEKQELERREREGDKARKEEPETRPKIVWFKPTDKRVPLIAIPTEQAPADFIDNPDAYSNKLFVATIKRWPITSLHPFGTLVEELGTIGNSEVETSALLKDCNFPTEEFSEMTMKCLPPMPWSVPEREYDVRTDLREERVFTIDPHHAKDLDDALSFKDNKDGTFTVGVHIADVSFFVKANTQLDREARKRATSVFLVQRAVPMFPPVLSEDLCSLVPDTERLTFSAIFTVDEEGNVLQKKFAKTIIKSCAKLTYDDALTVVNGGALPRSKTSGTHLATDIEGDIRSLHSIAKKMRARRIENGAMVVSSLKVSFEFDAQGRPVDCQTYQKGKASTIVEEFMLLTNQSVARIIGNALPEQALLRRHEPPSERRLASFVTRASKLGFDMDPTSAGTLQKSFENVLDNDSALCIDLLRKKVIQRARYFCAGMLDIAKYAHWGLNAPLYTHFTSPIRRYADVLVHRMLDACLTSPNPNEVKFLMDRDQVAKAAQQCNMKKQSAKLAEEQSVHLFLCILINDLTEHYGPVVREARVTNVLETAFDVIIPEFGVEKRVHVDKMPVETAVYDEHRDILSLYWTTKDVISHLADTTEDRHLLKIKSLGEQRALGSSVSKATDDSALFDGNNAGVVSKQYAKSANPSPLKFEGLRSVDGGHKVQDIKELMTLPVIITSDMTKSPPVLVVYACNPYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQA8</accession>
    <name>A0ABR3BQA8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612804.1">
        <property type="nucleotide sequence ID" value="XM_066759317.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991711"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="145" mass="15824" checksum="D5F10D5625A6D51E" modified="2025-10-08" version="1">MPPKETSIHHITFHFYRSAVLLSVPNITTFTSLKAALLPALQPLAQTLPISLPTSPDDIQFWEFVNSNSAGEEGDATAVGAAGEEKTLRCLENDPGIAGRDIKQLGWPRWKTILVSFRGEDGSFKEPIYTIPDPDDDNGGSETEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQG2</accession>
    <name>A0ABR3BQG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613377.1">
        <property type="nucleotide sequence ID" value="XM_066758929.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991308"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17860" checksum="9F35838A66DA4283" modified="2025-10-08" version="1">MPRRNQPRQSAPQASQPSASSSRQNDALQEFQARRVQRRLDDLERTNPTDIPASSFVPAESSQTAAPGPSQQLPARKKQTANVRRILYNKKSLKDWIDELPAEPVPPYLSATACAPSTPPRRICSSCGYFGAYKCPRCAEWSCDRVCMEVHERDGGCGIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQJ2</accession>
    <name>A0ABR3BQJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613415.1">
        <property type="nucleotide sequence ID" value="XM_066758967.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991349"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="142"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="429" mass="49405" checksum="4DDEA6E24275132D" modified="2025-10-08" version="1">MVFRLTYAYVAIIVCVTTLIFIAHIHPGTSFYLPLLPSSYTTNYYTYTFPDPLEAENRHLTEEQCQERYPDLYLEADRAQEWFMAKGGISKKMVDGAEEEGNARLVILNNQLFVKAYKGGINTRTQAAIAAVYGTILTATEPLPDVDFVIQTSDAGGGHHPHFALCRKANQKDLWLMPDFGFFSWPEPGVGSYSEVRTKTLDYELDMGLEVNDKLEVTESDWFNKTQQLFWRGSPMVEVRNDLLRASQDQPWSDVQPLDWGKVGQDEAERLKNNGDLKSPAEHCKYAFLAHVEGWAYSGRLKYLQQCRSVIVAHPLEYIQHYHHLLNSRDGDPNQNYVEVPLPLEKNLPKVMKDLLNEKNEEKVQRIADNNWKSMRQGWISPAANECYYRHTLRQYASVQTFKPSLEGRAVPYESFLLMGKTHWDPHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQM0</accession>
    <name>A0ABR3BQM0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LAA1-like C-terminal TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613451.1">
        <property type="nucleotide sequence ID" value="XM_066758049.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990411"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="898"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="4">
        <location>
            <begin position="1828"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="2014" mass="217460" checksum="94097104E2EDDF42" modified="2025-10-08" version="1">MPGISPEVLRVEEVRDGSDLSLLHWLRQAEQAIETIDPEDLSKQIQSLHAFFLKLILPNLNPTLPKPGRPIRHLVTRCVVKLHQRVESRSLFDFVQALIKAVSDGGSKGMNTAENLGRVASWYCIGEVIKEHGKNSVLLRTQAMVAFSRSLHSAGKALPDALVKDLLKSLRSGLQDKALSVQRACAGTFISLHLYTPAVQLQPTLDMVAPISFRSLETADHLTRREFSRMLAHFLAATQVPGSGVVPELPRKSKTETEEQSGEPTVMTSAAEDRTSKTLFTTQEMLKYLSIPYNKPQSPRKLRNAIIDVYTTLFTTLGGEYVEARYGEIVKHIMDEIVLPQRGGRYEVLMTRQVAKILLRDLTGERLLSEPGQVSAIRELTVNYLKRWQPTLLPGQPRMNKNVLIVVLREIAGLLEQLGNAPAQITELLAEPLVRLLAHESYSVRLSAAFTLRRFCTTNPSQLPRLLSILIADIEKDLNLLSSPTAPKEIAPRLIGKAFGLSALIAISPARPLYVSHDVPTKVFDLAVSLLKRAGDHEIPQASTEIQVAWYLVTGLMSLGPSFVKLHLPQLLVLWRNALPKPSSKDISVGERGEAEWNFLLLVRECALSAVLNFLDHNQSLVNIDVARRLATLFTNTLNYVNGFATAYAEALREQANSPNPSPVFTTRPSLVDREATLRRRVLRCFTALGPSSATESTQPALLQAAITVFADPENYSGSGAQAAIAAQAGNFGGIWHSADGYAFGVTSLARARDDYGKNGEEDEGEEGWLNRDRMEIELEEQLSRPILGSLEHDFLPLLAAQQPLSSPAPAPAQTGVIDAGLSLFSILFPHQNLEGQVQSLATLSSHMRSSKLEKNPGRKQAVVVNTVTALRKTLKGVEGSGGKARKVVGSVQVSEMIRSLLQDAIFDPSPNIRSTSAEALGLLSSLASSTHLSSQVQWLVDQVVTNRSPDARAGCALAFGAIYSSVGGLAGGPILKTIVNILMSLATDPHPVVHFYAMKALARVVDAANLSYEPYVPTTLGMLSNIYLLETHEPEGGSLGSVNLRGDLPAYQVICRILHALIGVLGPELQEPGKVRSLVFLLVHEFGEETDEGLAVEAIKCVQQFLMFAPTAIDIPKLVQTFRTHLASPRRPLKVASITALYQIVQRDPVLISKLGGNQLVEDLFGLLDDDPSIDGVKKVISSWLRGTAAALPSGWIDLCQRIMTRTAAQKAAARRTQQASAPAAGPAFIDDEGESLGGGASTSTSSNALSSRWRTQLFALQCLHDIVVSVAEGNRPEHFDPVLARRIGANGRHMLWSRVGDLIRMAFSASAAGVMEVRIAGLVVLRDVIEKFSASPDPDFESALLLEQHQAPIAAALTPSFGSDSAPEVLSLAVQVCAVFVGSGVVKEVPRMGRILKLLTGALEQCKNGEMLSLGDMEEPSPSAVIMLQISVLAAWAELQISSIRQSYLTDVLKPYRWLLAPFWIGALRDYAQLRTDPEMGGLSGAVDSTAGLGREVLLPYYEQAVPKLLHAVAISFAINDPFAFGAMDGQRYDSPNSPTSLPSIRPEPSANFYIVYGLSFESLLKTIGDVCASSLATACLKAMQSLVKPVLSGTTVFDGQFFDELCTVCYRIAMSEPANVKSEAVEMMSSFATSRKGTGTMDSAQTRRVLAVVAFTLRQIVPTKEVIPSWNHVDSTQDKVNLLRSAFMAYAQIIECVEVSQKADMYAVGLYLFMGLLESESPVDLVGGCLGCLKVLVEGLVAAQVPGVSNGEKIVQGVVSACLSNVGDMRARINPVANIKIKNNLLAVTLILTALPTGLKVSKNLVESVGYTIGQYLGADIERPELGLTAIHCASTILSASLRLLPSPLGPNSPPAPSPVLQHSTLHLLPPMITYISDNVVAHATNPDYAPHLEGIQAVIKSLVSWSTGLPDEHKARGYGVVLPTLCLMLDPPGSTSQGQSASQLHGVAAAVLLGLAQSGPTAFKEATMAMKEGERGELEHAIRDAVGQKQGAVNGGVAKERKGIELKSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQY3</accession>
    <name>A0ABR3BQY3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613564.1">
        <property type="nucleotide sequence ID" value="XM_066758162.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990534"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1373"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1420"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="678"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="796"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1436"/>
            <end position="1454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1454" mass="155193" checksum="45930946946D7D3C" modified="2025-10-08" version="1">MPDEENGTPLSQETAVDTGRGGERDSDVRHEQQEQQEQQQQQQPDDTQEKPPTAKDSNPAPAPPPKKKVFTSLNVNQKFLSKTTTPAPTPGPQKQPNGRQASPVPIPSTSRQLSTKLHTMPISKPSVSPNPPPSSTHSSPWAKPSVPTGPSSSAASTLLHQPAPTRPGISASIPATSAAAPLSGASSGPGTGTAARNVWRMGGLGSRSGMTTEFPTAKEAADGQKAAAQAAALAAQVQAAHNQAIIQELDTFTRLEPHSHRWDEEDEEDDMIDFPDVPHTSPPARPPPQLPSTDDQPQQPVSKSDRFAEDFDRSWPPRRSGGGDDARSKDNTNEKVLFNASSNRLESRPEQQSTRLDTGKSGEKERPWGPKLLGRETGDVGSASASASASASGLGGKRSLPPHLSVSDAPSPSPFGTAGEGPSAASGSWRSSAPARPAWSGSRPTPSSGAGGGGGGGGMGEQRQSWESRNDERERERERAVGSGSGISGQGRRSFNAGQPPRSLYTHPPPHTLPHPHATSTAAPLAPASSTSTDPDPQSLEMHTAAEKARLRRLEEEKEREAAKERARMKAKALEEKLKAAQPESQQQQQQQQQQLQLTIARREGVPLRTTSSEVDKPSRAESEPSWRARAQPPPPPVPAAASSQETPRLPSSSSSSSSFVRGERTEEEKEEKVMIPLDDAAGLGASSSPSLENAQQPTSSSSAATATATATAQQQPALSSSSFDGMLARVKAAMLEMQQTREKEVREKELEKEREKEAVKQVQVEEKMPAKEEVEKRHVLKASRAEQVKEEKTKPVTTTTTPKATTPKATSTSQTPNQTSQPPSSKLPTVSAPAAEYEPPQFFDITYPQPPRSPPPAWRTYNIRLPKPSSLPRPRCFDLPAISSTQQTKWEKGVAAPKGWARTFEPPLEDEETIEDVLDRAKMLLPQSRVVTKVGEIVVSISPRVLERVKERRTGVDGEIKEGREKRRAEKVGRSVVEEEGEGEEEVRTGVEKAAVLLESSTKPVQAPAPVPPTTTSSTTQQQQQPPPRRKSPVKSAAQAEKDPSTFILQGVGLAIAPPPHISLSSLPASSVSGSTSRDGKDGSFSLLSEDGKPGVRFMVSSELEGDSLLEEVNKMSLESVEEAKGEKNDDKEEIPTTPPLAHQSPKSNGPSTPWSKTSLAYSSQPHDAIKSVWGADTSATTSDTPMYPSLNAPVSTETTQPLATGLKSGFPTHAHSSSSGPQFSPNLSAANVPFTRHPSQSQIQSPYFGSPHHTLSSPPGDPSMGMTMPLGGYNRQAVNAMGVAGVNGFQQGVWGGFGVAPGYGYTPQPQHAAHQANQGQQKFQQYTNVPPYSRVNPNVTYSYAPTPSPSYSHPSPQVRPQGRFAQAATNGDYRHHPHQGQGTSGLQPQPAGFGMSMDGSNQGYYGGIGMYSPQAQHAVNQGGPGQIGQSQGQGQQGYGRGMMRGGMGRKMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR25</accession>
    <name>A0ABR3BR25_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetochore protein Mis13/DSN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613315.1">
        <property type="nucleotide sequence ID" value="XM_066758867.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991246"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="69009" checksum="8F26DF914335D682" modified="2025-10-08" version="1">MATRRSTRLSGELDATNKVVNGKRKGAAGGKDDNSEIIIRKKKQGGKKSTFQPQPVPLPDSSDTPPSPTIPLDLPPPPPSAKIARRRESTRAIRERPLSESPPSGPLLQPGIHPAKKQKVARGKSVEPLRGVAGTADDPLKDVEETEAMRNTGSVPFVQYLTFSKSSKPRPSAPRPSSPPRRTFASSSAAAPLRTPSANALTKSGTMGPPTGFVRKTRKSMGRVQELSKDVMMPIMDSETPVIRKNQELRGQQARRSSMDHRGGRASSSWGRGDITMPHKSVDHKLFYRHIPTAYPDPIKTRMLLVWCTNRAIDENLKKSSASRKGKGKQKEVMTEEGDRMLKEVMEEFVQSMNRGSVDTSTYALPGQETVSFSGLQPHPRNVQNRKAEAEMTAAIRKYKEEGAQWSAIVNATNNKQQETIRLLEKKMMTNAEPDMSKAAPWMQQALALADSIIAEEHGGLQHTDDFEDVEYKVDTLHQTSHVALQYVLQASRFLDGIFSSLTADLRARDRLGLPPDLPPHDTDGPDTTALLTSARLSAAPQSSTFASTSSSKQPRGKSRPDAMSLLRSLASAESRDQSDETVTAAAKVAPMLAISSMTPRRPAAGMTPRRHPLGAATPRGMKGMTPRPERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR94</accession>
    <name>A0ABR3BR94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613390.1">
        <property type="nucleotide sequence ID" value="XM_066758942.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991321"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="88"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="338" mass="37092" checksum="954ECD9B6D87F8B0" modified="2025-10-08" version="1">MEDGHPHASTSQPPHWALVLRAKALRNAASFGYMIHHYANPAAPSATITRWIDCTLGEKKGKKVIRLDVYVPKGVKLGTAEPANRPGVIIFHGGGFVLGHGTDDARWAGAVCEKMGAVAIAVSYRLAPEYPFPTPVEDCASSILHVTEHAKAYGTDPTKLFISGFSAGGNLAFSSYHLLHTPSKWGYTLPIVPPPIRGIITFYPLLDYSLTRPEKRAACEKPEFTLAPSLTTLFDSSYLPPGVDLLDSRLSPGIAPDGMIEQLPSVHLAICEYDMLHAEGVRFKQRLESKGIEVSMREIKGEKHAWDKPPPMSPKPSVKEEYDATIEIMKRWLDGKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRC5</accession>
    <name>A0ABR3BRC5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103642</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613531.1">
        <property type="nucleotide sequence ID" value="XM_066758129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990498"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="245" mass="27722" checksum="4213DE014B80FCD0" modified="2025-10-08" version="1">MPTTPTRHPSLSSFFLSHFYSKYPDFSFRDIHKQHITYTMAAHSEQIKNNFLNNPYAQQVCNIVNGQVSALDAELNRYPVLRQLEQQTKVPKAYGVIALGFSSVLLIFFNMFGLAQPISNLIGWALPAYLSIQAIESPQSNDDKQWLTYWVVFGSLNLVESMGLRAVLYWVPMYFVFKTLFTIWLMLPATRGAETLYFHFLRPMVGNVKSRSQASFGTTDPLAKDTGFNPAGTTAPSSFAHEKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRE7</accession>
    <name>A0ABR3BRE7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613727.1">
        <property type="nucleotide sequence ID" value="XM_066758325.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990700"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="50535" checksum="61BDBE9F5031453E" modified="2025-10-08" version="1">MPAPPPVAYATLSSPLPDAPYILGITPSPTTPHLVLRHPSKSLTVADNQTLQSVATLQGAHGGHISSVSCDGGELWSAAVDGSIIRWDERSRQKATVIKAFIRKPLPVTALTISAHDSLVIGGTELVSSEAHILFWDPRNSSAPLYTHSSTHSDDITHLSLLRSSSTFLPASHNPEIKTPGTLLLSASTDGLIALSDMKESDEEEALVAEENWGQSIADAGGYMHKGKMGVWARSDMDEMCLWGVGRGNIGEIELQDHKQYPSSEFKFKTFTPPKTGPSITQTALDEFKSKTTYKSDYLINVVPTLGISSDGAPMTTVGTNEGDMILQHHSASTSSYKPSAFFLSGPGANRGHKDVVRAMYHDLANEALYTGSEDGVLAGFSLASLPERLTVGDPDVDDDGGDSREDDEDMDEESEIETESSEESDNDEDEDMEEEGPRYGPIIGAGSKGRPGADKKEDRRKKRYEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRF8</accession>
    <name>A0ABR3BRF8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612543.1">
        <property type="nucleotide sequence ID" value="XM_066759056.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991444"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="172" mass="18082" checksum="C6BAADAD74B5D115" modified="2025-10-08" version="1">MRFFDIFSCCGSRRDKLKDPEPASESATLLPPARAESIVSADSLVGYGATEQHGLTEEQRTRVAAIGREVGSYMLSVSTSPQNHSSSPARRFSTSSAGSSRPPSPSPNRPETTPANGKLEAPNGNHEPKGDEEDGVVRKNLFPGGNMASNSKAKKGKGKGKGKGKGKGKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRG7</accession>
    <name>A0ABR3BRG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BD-FAE-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613747.1">
        <property type="nucleotide sequence ID" value="XM_066758345.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990720"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="306" mass="33312" checksum="66B200F1FC50D937" modified="2025-10-08" version="1">MGVFKTITFAQHDGVDIKLDYMLPQSASSASNLPILLWFHGGGLLQGTRSCAWAHLVSAVEKYKLCLVSADYRLAPQTRMPGIMKDIKAAMDYLRSAEFLSETGNAVDQNKIIVSGGSAGGWLALLIGSGVGFEACGLTPPAMPLGVVPIYPITDIEDPFFTTKQHPVSYVKEIIPESAVAAYLDPKAPQSSGCPLTSPRMKCYPYMVQEALEQKLLLDGTKIPPSAFSIAPAIASGKFTLPPTYIIHGTIDDKVPIKQSEDVFKACKQQNIDVTFEALEGVDHLFDMDPKYTLDEMYAFITKLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRK1</accession>
    <name>A0ABR3BRK1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103557</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613453.1">
        <property type="nucleotide sequence ID" value="XM_066758051.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990413"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="8">
        <location>
            <begin position="26"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="476" mass="53720" checksum="188B09799B91A8B2" modified="2025-10-08" version="1">MPLPQLFKLPYDRVSPKDKESFAYTTLVKRWPVVLTNVISAVSNANHEISMSSSADKDAKVTEGKKIISQISEMKYEMGHNALLSPIEDDGEINVDCYNEELASYPEEDRKWANMNWLFAECYVYRRLRSYFALTQYWKSYDPFFDQKAETYRSSSGAILHLAKAINSAVAEKYELDKDFEKPGSALEIAFMEMIQADLWGNATDLSLLIDLKYEDLQKLQAVGSEAQAEQAKFILRNDLSKTWEHIKGLKDGRIDFVMDNAGFELFTDFILADFLISCTPFVGTVVFHPKAIPWFVSDVVPYDFAWTIDSLLDATFFSQHASQPLTDEDTVSVTSLGKRWKAHLEAGRFKLSVPLDTPFGKAPAVGGFWSTQYAYQDMPAMAPDVLAELQKSDLVIFKGDLNYRKLVGDAWWPTTTPFDEAIGPLAGQITLLSLRTNKADTIAGLDEGVAERVDKVAPDWRVSGKYAVVIFSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS15</accession>
    <name>A0ABR3BS15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613917.1">
        <property type="nucleotide sequence ID" value="XM_066757533.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989887"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="137"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="781"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="791" mass="84732" checksum="DDCDB07A8DAD3CF2" modified="2025-10-08" version="1">MSNERGRGRGGNRGGRGGMEGGSARRGAWRNGPPSAGSFPHSRGGSPALGQSPTPRMSINDHMHDLKIVQGERKGFQTDTDISRTAGPVERELQPWVPDGPSPQPQSNGGSGNADFETFGTSNNITWDQFETNERLFGAKTDFKEELYTTKLNKSGPDFHKREKEADRLAKQIMGQTSKNAHIAEERGQTIDNRDEEEKYSGVSRAPNAYVPPSARRAMGQSSTALLPNPATESKTNGSTSVPAKSPSHAAVPTIETAPPVPERRISDDPIGSKVEAPAMKVTGTTIRPITESAEVAVNGASSIAETKPELSGVVNEWRQFVGTEREKVEAKKQSVLKSEKEKQLADFKKFQANFKVPLPLPKDILPILSKDEAKQKDIEAKATSALQAAKERKSSIAKDSPAKTPAILSSVKTDAPKPAPPKKIVMKIPEIPPFNAAKRKAPAVPVPVSATKDIKVITSPTPSNGSLASQATKLNPTASTFVFKPRADAAPFKPGQSSVSPSIAPHQPSAGPSNVSASPAAQKGNVFFRDKLPEKTHINAREDFNPWRHGPVPRPNTVGTGWPYPGRKVGVPPPFMSPAAPQQMQMQFEDDPTSPSPHPAQPAMMPGMPPNYPPYGRFQPGMPPPYGVPGGMQNPMFSPGPQFSPHPGQPMGQPPQHMMPGGPQPNMPMYFQNGMPQNPAFLPPQMQQFPHNPQRPGPGPGPGPGGPQMFYPNQMPPMPHQTSLQQHPVPFSGPSPAQSQFQHQHQHQHPHPHQQAPPPPPVQISPAHSGPGGPGGVVQGGPQQNGQTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS41</accession>
    <name>A0ABR3BS41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613969.1">
        <property type="nucleotide sequence ID" value="XM_066757585.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989940"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2221"/>
            <end position="2296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0249782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="2514" mass="275376" checksum="660B7D101CDDADEB" modified="2025-10-08" version="1">MASLFSSSAPMRPLVLHDATTRVSVHVPASPLSAWVTSQVVARDFQDSIVGKDTAAPVADEEEEPSAPSIEPQVTLLAQFLSFVADRAAQDASSELSEVLLAAYNRFNELFLSTINVHSLVQSFDPEVRAEILKSYFKAFATAREQLGDKVQIAHPSALLEAAKNGSTELYALFGGQGVNEHYFNELQLLYDTYTPFVAPIISEITDLLISLGHKADNNGYTYYSQGLDLLSWLDGSSPRPSVEYLASIPLSLPLIGVAQLAQYVVSCRVTDLSPAEMRERFKGATGHSQGVISAVAIASSSTWSSLYENILKAVKQLFYIGLRGQEGFPLLSIDPKIVSDAIENNEGVPTPMLSINGLGVKALEGHIKKVNSHLPSNSQIGISLHNGPTNFVVTAPAKALYGLVTALRKVMAPAGLDQSKVPFSKRKAVFTMRFLPVNVPYHSHYLEGATQKVEKDLGEELWDPKALAMAIYHTEDGSDLRSSEISLTTSLCDQIFTKPIHWVKACNFPSTATHAIDFGPGGNSGIGPLTSRAIEGRGVRIVVVGEKGKAAAEFYDATKIRREPVWAKEWSPKLVKTLDGKVHIDTPFSRLLGKPPIMVAGMTPSTVGANLVAATLDAGFHIELAGGGHYNPKALRAKVAEIQRRVKPGVGITLNALYINQRQFSFQFPLWQEMRKEGLPIEGFCVAAGIPSSEKATEIINALKEAGIKHIAFKPGSVEGIRQVVNIAAANPDYPIIMQWTGGRAGGHHSCEDFHQPIIATYPSIRQNPNISLIAGSGFGGAEDVWPYLSGEWSVKMFGLQPMPFDGVLYASRVMVAKEADTSASVKQLIVEAPGVDDAQWEGTYDKPTGGILTVRSELGEPIHKIATRGVKLWREFDDTVFAQPREKRAAWLENKRDYVIDRLNKDFNKPWFGEKSDGTVVADIGKMTYEEITKRMVRLMYVAKQDRWIDVSLRNLVGDWLRRAEERFAGVDGIRTKESLLQSFSDLDKPLPTIESFFNTYPRAKTQLVAAEDKAFFLAICQRPGQKPVPFIPILDNNFEVWFKKDSLWAAEDVEAVFDQDPQRVCILQGPMAVKHATVVDEPIKDMLGNIEALLVKKILKEFYNNDESKVPEIDFIGAKPGKPKAGLVSESVSGDVRTLKVGKNVPALDDWLEVVAGANVSWLRAALTSVNVVQGAGYISNPFRRIFNPRAGQTVVIKSENGKVVSVTVYGAARSFGPYAADFKAVELTFNSRTNAISLVMNEERRGVSVPLHFAFAYHPEQGYAPIHEVVEGRNKSIKDFYWRLWFGDDEKLPSLKLDTTFTCDESNVDALAVQRFCDVVGNQGEAFKSARNEKIMAPMDFAIVLGWQSVMKAIFPDDINGDLLKLVHLSNGFRMMDGVAPLRAGDACSAEARVVSVINSDSGKTVKVKGYVLRGGEPVIEISSSFLYRGKFTDYENTFETIDESDYVVELSKPTSVGILQAKPWFEWDDDSVPLDVGTTLTFKTKSELRYKDKSTFSSVKVSGAAFIRDSTKALIQVATIDYEAHNLQGNPVIEYLKRHGTAVGNPTPLESGYSLIEDPTTAVFTTPATNEPYSKISGDFNPIHVNPYFSDLASLPGTITHGMWSSAATRKYLESVVADNHPERVASYQVGFVGMVLPGDEIQVKLTHTAMRDGKKVVKVEAFNQRGEKVIDGSAEVLQPPTTYVFTGQGSQEVGMGMELYNNSEVARAVWDAADAHLTSTYGFSIVDIVKNNPKELTIHFGGIKGQAIRQRYMDLTYDTIDESGRVKTLPLFGDIDLYTTSYTFSHPQGLLFATQYTQIALVVTEKAAFDDMKAKGLIDQNASFAGHSLGEYSALAAIADVLPISSLADVVFFRGITMQRAVQRDAEGKSQYAMMAANPSRVGKTFNEMALREIVDTISQQKSVLLQIVNLNVADQQYVCAGELRALATLTNVLNMLKIQKIDLEKLSTMMSIEEVKEQLAEIIEGCWDMMKKKEEKDGSVILDRGFATIPLPGIDVPFHSRYLWPGVLSFRNYLVKKIDPSQLNPDRLIGKYIPNLIAEPFEVSKAYVQKIFDQTASPRMEAVLGNWEKEAWESPSQRQRLAYNILTECLAYQFASPVRWIETQDVLFTYAKFERLIEVGPSPVLAGMATRTLKAKYEAQDGAISLQRQILCHAKNQKEVYYAFEDEAADEAPAAATASTAAAAPAPVAAPVVAAPAPVAASAGPAAAVEDVPPKAVDTVRVIVAQKLKKQASEVPLSKSLKELSGGKSTLQNEILGDLQVEFASAPEKGEDLPLDELGAALSVGYAALGKHSMALTNRMIASKFPGGFNITAARAHLNKQWGLGPLRTDSALFFGILNEPPKRLGSEAEAKAFLDQLAQSYASYSGISLSSGAAAGGAGGAAGGGAVMNSEEFDKFVLKQEEHAKREIELLSRYLGKDPREGEKKADEEKATAEELQAKLDAIKLEHGDAYIDGITPVFSALKARTFDSSWNWVRQSSIQLFYDIIHGDLDPSTVFNDPPRYRSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS65</accession>
    <name>A0ABR3BS65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613949.1">
        <property type="nucleotide sequence ID" value="XM_066757565.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989919"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02648">
        <property type="entry name" value="nuc_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF56">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0249762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="411" mass="43898" checksum="C9910C6689C4430A" modified="2025-10-08" version="1">MPHKVILDTDPGVDDVLAILLALSSPEIDLALISIVFGNTHAPVAHSNLLKIYHLLAQEVAQTAGAEARYGRLKGQVKTMLAMGEDGPIGGEKAVAAYFHGPDGLSNISETHPHFTPPEIQPGDMHAHLDTSPKPSYEVILDILKAEPDDSVTIVALGPLTNIAHSLRADPETFAKVSRVVWMGGAIDHPGNTSPVAEFNCFADPYAAASVVAAAKEGKIELIMAPLDITTPHSIPFSDLIHPSVAAIPEPSTGVVRKTSETPTPLEAFISAMLVRVRSLQANFGLPDAMEMHDPVAVWYALAHAGVPRGAGPVEGWALNGREFTIERTGEYTRGMCVVDRRGTGEVGVDRSKDESILSHGLEKKEKENNALPEKKNGVVKPRGLPLIITRTPGAEALRSTLLGRVFGKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS79</accession>
    <name>A0ABR3BS79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614003.1">
        <property type="nucleotide sequence ID" value="XM_066757619.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989974"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="3">
        <location>
            <begin position="108"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0249816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="215" mass="23285" checksum="1A8FF2334516336F" modified="2025-10-08" version="1">MALPTLRNTFASSSRITLHQVPFPSRSLAYLRYGSSLAQPSSSQSYTPTPAYSGPVASSSSSKPKGGVKDMHAAPNPAPPVAPAKNEVTGEKKEPRRRVPLKGQRNAITMTPTAISHLRELLASPTEPRLLRISVKSRGCAGMAYHLDYVPPPGGKFDEVVEQDGVRVLIDSKALFSIIGSRMDWRDNRLSAGFVFDNPNVVDTCGCGESFNIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSD5</accession>
    <name>A0ABR3BSD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional repressor Tup1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103139</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614024.1">
        <property type="nucleotide sequence ID" value="XM_066757640.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989995"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053299">
        <property type="entry name" value="ASTRA_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44156">
        <property type="entry name" value="SUPERNUMERARY LIMBS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="8">
        <location>
            <begin position="31"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="328"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="422"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="482"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="524"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0249837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="564" mass="62406" checksum="8F4C762F8C2F16EA" modified="2025-10-08" version="1">MQPPAIYNHHRLPPAGTPSQPSVLAQPSTARLNELFDLIRQEYESLGTDGNIWKQQRDEYEAKVQSQINELGMIRQSLYELEANHAKIRQEYESEIARLRRELESRGGPSSSAPSGTAAALNNPSPPSELPRPGEDRPSFGMALPGPTLNGLDAGRSRSPYPNPTAGPPILRPPSSADRDRERRVTRPPQFNAPPSPPVHLSDLDPDNVSRELRKEGPDWQAMWSSQMRKQLDVTLVHTLEHETVVCCVKFSNDGKYLATGCNRTAQIYDVKTGARVSILQDELANRTGDLYIRSICFSPDGKFLATGAEDRQIRIWDLKQRRICHLLQGHMQEIYSLDFSRDGRFLVSGSGDKSARIWDVEKGTCVFNLQIEDFIHNEHGPIDAGITSVALSPDGKLVAAGSLDTMVRVWNVSTGQQVERLKGHKDSVYSVAFSPDGKCLVSGSLDRTLRIWDLTGTKREVESLPPGKEAQKNLGTCQSTLNGHKDYVLSVAISPDGQWVVSGSKDRSIQFWHISTGQAQLMLQGHKNSVISIDLARSGGYLASGSGDCMARIWKYEPIPGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSJ7</accession>
    <name>A0ABR3BSJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103238</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614122.1">
        <property type="nucleotide sequence ID" value="XM_066757738.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990094"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="12">
        <location>
            <begin position="147"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="435"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0249935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="468" mass="51863" checksum="2E5C3CEF4B14F9E0" modified="2025-10-08" version="1">MLARSAIHRALRTAARRPPSRLPLAPRLLARSFSVTPWRHSQQPLQRPLPPLEQSEAASTSTSAPVPSTPADLLPQPPADAATPTLEDLILHSGKSVQEVLTSEEAVHAAMKLSDLKLIGYDHGILSITGWFTDGLVALHTELGLPWWAAIAGTTVLIRLCLTRLVINTQKHSVRLAAVNPQIQELMTEAKTASANKDTHMQTLISQRLRDLMKEHNVNPLRPLMLPLIQMPIFLTFFSIVRGLANLPLPQLKEGGLGWVTDLTAADPYYILPATSLLFTNLVFKFGADGVPTAAKAGSPMTTAHIRNFIQLTTFLSFPLIMYFPSALLFYWTFSTGFTLLQSIILRQPIVKRYLGLPITKAQALEPGAEPFKSPSYMDTFNAAKEYFQKSVKQASEESAKRVHAEQNAKRASSVKRKQQGEFVERIQEPGVEVKEAAAAQTVKKPEGGREAEKQRRIEEARRRRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSL6</accession>
    <name>A0ABR3BSL6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613828.1">
        <property type="nucleotide sequence ID" value="XM_066758426.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990801"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11332">
        <property type="entry name" value="AmyAc_OligoGlu_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="18"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="563" mass="63596" checksum="A072A5399FDEB5E7" modified="2025-10-08" version="1">MTDQEIDPDWWRQAVVYQIYPRSFADANGDGIGDLKGITARVPYLKALGVDAVWLNPFYPSALRDGGYDVANYRDVDPKIGTLEEFDEMTAALQKVGIRVMVDIVPNHSSDDHEWFQAALKAGKGSPERERYIFRDGLGPNKDQPPTDWICSFGGSAWSPSGMNDGQWYFHWFDSSQPDWNWEHPDVKADFLKTLKFWGDRGVAGFRIDVAHGLAKDMSEPLPNWEQLKKMTHQKLTNGNSALDHPLLDRKEVHDIYKSWREVFNQFNPPLMAVAEAWVAPDQKPLYASSEGLGQTFSFDILLCNFDAEEYRQCIKSSLEGSKKSNSTTTWVLSNHDVMRHPTRFGLPNVPNANHATATAAYNKFLQTKLMDPKLDVEQGLRRAKAATLMILALPGSTYLYQGEELGLQEVIEIPDEERQDPIFIRTKGEEIGRDGCRVPIPWHADEKNFGYGSGKRAHLPQPAWFKDYAVNVEEKDPNSVLSFYRRALGLRKELQAAEELEWVENPNKEVLHFRRPGGWEVIVNIGKDSVDLPKGSILLSSSSNALKGSKVPGETTVWLKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSR9</accession>
    <name>A0ABR3BSR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614174.1">
        <property type="nucleotide sequence ID" value="XM_066757790.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990146"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="74635" checksum="CFA7BF030426FB0C" modified="2025-10-08" version="1">MPHPFDSYSSRSSTSSSESDSQESSATSYSLPRYNEKPRQYSLPRRASAKFRSVLRSRRRSSLPFVHVVRRRTTQLALAAGILVLGALLLSEFKNHNERQRLWNKEFPLQEWESKHSGDREVNLFALRADYESKRREEMLAERKQRIDSGSLDKEQLWTSQQDEALQQEASDKWPSWWGNPDVVGRSPFDHRPDPLPPTREKRRFLMLTDYKDYLERMNTHTYEIVDAALRHPHLIVDVWGPGWAGYNRSIPLSANIRKRAHRVSQLEKNKAEFEKKQRNKRGNLAEGEEQETWQTPDWPDVVPDECSDVRYDVVLTISNIYREADPHLDFLDCGALMIQQLGDCHSLRCSYEWYPQSNNITLSKYAFELLELFDYNKVKAKYPDWEMGMFGHSPDTGNEWDFWPVTWSKKTSEARIFGFDGSFYPIRTTVTNHLRDAGKQEKETLISRHPHPGYTVSVPQEARDNPLETYERNHKYYATHLKLREDFAKGMRESKICVFDASLERKMIRKYAQAFLSGCVVAADIPTEHESALSKFVIPLKATWSIEEINTAIQYYLDRPEVLQQMAVDGFVYARQHLTTTNKISHILEMADHYREGSRGYEFPYGFSLKCRAYWSDQNGYRPPWCRNTQGYRGLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSU9</accession>
    <name>A0ABR3BSU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614211.1">
        <property type="nucleotide sequence ID" value="XM_066757827.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990183"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473">
        <property type="entry name" value="BTA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="150"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="839" mass="95197" checksum="2B17A8AF5901AEF0" modified="2025-10-08" version="1">MAIVLAKAHHESIALPHILLILSAGATIIYLQPLKSLLTAFVPLSRPSLGYALVFLSSIALTLGLWPALHIPFRFMYNCFLKPFLHHGSGDQKNNLEAFYAGQADLYDTTRSHLLKGRETMLQLLAAHLKAQPVVRLPVAAAPAKPKIWVDLGGGTGWNIEKMDEYLPLTYFDAIYIIDLCEPLLEVARARIKARGWKNVHVLCQDASRFVLPEWESGAVDPRGSLTAITMSYSLSMIPPFYQVLDRCDQVLDPQRGLMGVVDFYASREAGSKERAIGTASKRVSWFSKWFWECWFDLDGVHLHGSRRDYLEYKMGTIKTYNARNNFLNTWFIQIPYYVFLGCSRQRDASASAKSFTLEAGNRLGQSDLGLLTPTSPFTNSPSIFGSPSPMLEMPELVLGPSATQATQTIFEVGAPLSPFHYHLRKAWRVPYLEEKIHEQFRTHIYGWTWEDPAVDVKKLNINKDDHILAITSAGDNVLHYALTAKPARIHAVDMNPCQGHILELKLAAIQALEYNDFWLIFGEGRHPEFDKLLTTKLSPFLSSHAYAYWKTHASQFSRNFYFRGYSGWALRLAQIAFFIAGVRGDVKRLCKATSTAEQERIWQKKIRPVFLNKVMVKLFLGNPLFNWHALGVPQNQMNCFLQDGTVEDYVKATLDPIPTLSTLKDDNYFFLLCLNGRYTRTSCPAFLKPEGFKALKNSKSTDAFKLHTDTILNVLRGLPDESLTKIIVMDSMDWFDPIPPSTPLPQRDSTALDTLQMTPEKALEHLRAELDYEILEMKRVLKVGGIAVWRSAAKRPWYRQRFEAAGFKVQPIDIRENQEAIDRVNMYASFWKAVKAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSX0</accession>
    <name>A0ABR3BSX0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L6 alpha-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613098.1">
        <property type="nucleotide sequence ID" value="XM_066758650.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991028"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="21295" checksum="4942E721B1F5E2B2" modified="2025-10-08" version="1">MTARPVVSLSRQIHSSAARRSQVGKVPIPVPPSVALTLPASSVPPHVHPSSPEAHRVFTVSGPLGSTTLPISPSIILTPPTPSSSSLTISVHDPAVKTQRSLWGLTRTLISNAITGVSAGFNLEVKLVGVGYRAAIEPIPQVFMDLAKQTSSLPTDALPRERLNIKLGFAHPVLIDIPPQIKVTGIFVGGETIRLKEVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT16</accession>
    <name>A0ABR3BT16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614286.1">
        <property type="nucleotide sequence ID" value="XM_066757902.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990261"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05696">
        <property type="entry name" value="S1_Rrp5_repeat_hs4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05707">
        <property type="entry name" value="S1_Rrp5_repeat_sc11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05708">
        <property type="entry name" value="S1_Rrp5_repeat_sc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057301">
        <property type="entry name" value="Rrp5_OB_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24685">
        <property type="entry name" value="OB_RRP5_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="337"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="437"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="528"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="617"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="703"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="810"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="904"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1073"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1455"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1073"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1173"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1200"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1456"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1477"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1486" mass="163443" checksum="B73F30D0429D260C" modified="2025-10-08" version="1">MAQKKGSQLDNDKATKNTQKESLSGAPRPAPAFTSTLQSDETNFPRGGGSTLTAFEFKQVREEGRREAENEAKIQVSKGEKRKRQMSDRQAKRLKKNEDAKKKEERDKDNIRVEILNYKRLVPGTHVLARVHTVLPLHLILSLPNNLLAHVPITEVSNTLTKLLTAEEAMALDEDEESDDESTAPDLAQLFVPGQYVPAKVLTLYPTASQSFISQYPVTETTRLASRVELTLVPEKVNSEVAKKDLETGYFLVGEVRSEEDKGWIIGVGLNTEDGSSVEGFVSKDEVAKFVPAQALIPGQLLPATISAIAAGGRVVHLSLNQQDIARSQISEVSTVGSIVPGHSVNALITAVVASGLNVKVAGFFDGTIDLAHLPLGEHDIEDKYKIGKKIRARVIYDNLAANPHSFALSALPHVLNLTSPTQEGDDTPLELAIPIGKVYQSVKVTRVLNDWGVMVRTQDGLEGFVHISHLADERIPVLSNATPQFKVGTLHRARVIGHSPMDGVLLLSFEQSVLSQLFMQVSELKIGQQLRGTIRRLTDKMLFVNVHGNVDGIVHPTHYADIRLKHPQKRFKPEASVKARVLYLEPARNRVVLTLKKTFLESDLAVPQNFEDLKVGEVTLGSVLKIVDKGVIVELFAGLKAFMPHSECSQTHIKDLSEAFYVGKPLTVRVITLDPSTSRIVVSVKQAAPTAPATAAEKLEVGGAVSGTVSQVHTEQVVVKLESSGLTALLSLSNLSNQRHTGIEELRRSLKQGEKIDDLVVVSKNPVSGLIIVNIKKTIAAKKEKAKKEDKAPSGISANVKAIDAIEVGQIVTGTVQEQTSQGYMIQLPNNLRGRVHPCDSSDDLVLAAGRGPLSVGEEVKCYVLAVNKSKRAIDLSTRLSRVEGKEDVVDREINTVDDLKQGESVRGLVKNIAGHGVFVSLGTNVTARIMIKELFDEYVKDWESRFEINQLVSGKILSINPKSNSIEMTLRKNPSKSAKKTALLSLSDFEEGQKVVAVVRKVEAYGMFLKIEGSNVSGLCHKSEVTDNRKADVAQALKGFREGDQVKAKIVSIDTEKGKISFGIKASYFGEDFEGGEKSEEEDDDAEEENDEERSEGDQEMESGDEESGEGEEDEDGDEDEEVRAVDGDDEEASSDEEEIATQNSKPAPKTALNLGAGFDWTGEVPPAASESDDESDSDEEVTAPAKSKGKSKAVDLTATAPSSRPSSTAEYERALLASPNSSFLWIQYMSFHLQLHEIEKARKIGRQALEKISYREEDEKLNVWMALINLEIAFGTVSATEKVFEEAAQYNDKRTVYMRYAEALQVAGKDEALEELFKKIVKKFSAYPESWTRFAEFYLNKGDVEAARALLPRSMKSLDRSKHVETIEKMALLEFKHGDTERGKTLFEGLVDKFPKRLDLWGVYIDQVAKVGDIQGVRGLVDRALEQKLTSKKAKFLFKKWLAIEQRIGDVTGQDKAKTKAREWVEANAKPAQNEEEGSDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT22</accession>
    <name>A0ABR3BT22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104217</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613143.1">
        <property type="nucleotide sequence ID" value="XM_066758695.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991073"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="130"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="43"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0247182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="229" mass="25621" checksum="53B6E80265529848" modified="2025-10-08" version="1">MDSSPTALFENYDEDLKQLFGSLKDKLDGEAKSLTGEQRKAALKRVSEEIDEAEEIVAQMEVELPSMPVSIRQTYQGRLAASKQSLDKIKKTLKDLRLQSQRSDLLSGPGYPHGDDPYTDDPEPYSTRSRLLAGTQTLEDSTTRLDNAHRIALETEGVGSEILRNLRGQRDQLENTRDTLVQADSSIDRAAGTLKKMIFKMYQQKFLSAGIIIVLVLLILLVLYSKFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT78</accession>
    <name>A0ABR3BT78_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lethal giant larvae (Lgl)-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614345.1">
        <property type="nucleotide sequence ID" value="XM_066757961.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990322"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="662"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="5">
        <location>
            <begin position="745"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1170"/>
            <end position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1283" mass="140614" checksum="12088A551A9F0440" modified="2025-10-08" version="1">MFKNKAPSLPLDVDYTRNLRETNFYRYGHLRSLGFTGEVTALAVDPGLSLFAIGTSSGMVHCYGAPPFQFTLPVSPISSSGPAHVIKFLFFHPGHNRIIAIDDGNTIHTYTLEHMTDHPNPSLHPPLPMKEIAYTLWGTVTSVEQPSPCHTHLFLTVKDGTTLTWDLSRRGLGNWKIGNCWKDYEERMIRSGVPGREKTLGGPMATCLAMNPRDLNIMLIGYEGGVVAWDMQRSMVVKTFEMILPPGAPGGGSYQDADGSLWTERTPPVTFITWRPDGLIFAVGHVDGCIAFWAFTESDKPLMVRTITHEDVNVADAESLLESGALPNQDKKVERDRNGNAIVPAVSANREPIYKMAWASFPDQTSLKALISAQGTPQAGEPLTNATVELAERGETLLLILGGQSPGDKPGINILQFPPYRPPVNANPKSSSESMPLQERYAFRDSLSPTGSFNWLTRTPPEDFILIPRNNPYFNLSHDPVSIVISLAPDPSIPEIKQPYATRSLEAWVFPPPRSNVPPPPSGRKNYMQPGAGEKAVAMAPATVTSPTPISPRTGGGWRLPWSNRTPSPTLSIPAVASPDTPVSDISGLSGITTTLQRSAKMRKQLSFPSTVWSGALSVLGTELYALSTPVFKRLISWTIEHAGEEEMPRLPLRGGLAVPDLQSHGAPEVMVAKMESYRILVTYHADGTVRFWDVSPHILILPTPLRFEFPNPLPHLTISIGDYLKHPDVSHLPLAQLWWNDRSKVKIKSVHLAREALECVITFMTGEVLVTKFQKAKTLTDDDRYQEMLNREGDHVMEESEGSYFPPQPKQQGKNEWVEEVLEIGHLAKPKTDGFKPVAIFTMKQGEPISCAVSDIGFIAVAFSSKSLAIIDMRGPDVILREGFDEDGAVMKKKKKKGNVQNVLPESSVVGSLKWVVSGMGGDIVKRPRLIVSYDKGMTKIYALVNVLGEWVVEAKPPTFTNDSLSGPIASFVLDPMSGNELVTSATALQAAMQESTDHGKGKEVPIHCLWVAASKKSIRCAINFSGERIAKVELEDEELSNVFYITRHGHKIIIAVTTTGSALVYTVPFLQPVTRLNLFFGPQGRSSGKLSIDDRSGDFVEYNGPLDINLRTFFHFRKPLPPRIDPCAHKKSVPPQPQPVNAGLISWIWGAALTGAQLDALIAGPLRPPPPKVPASPHKPLISWGKPEEEPEKPPQLPSNTLPNRSAVKKTKAPKAQEGERQDVYTEMTNAVSLRGDVLDMLGESLNNVSMSATQYLGQAKNTAMKETAKAGAKGIFGKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT93</accession>
    <name>A0ABR3BT93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614053.1">
        <property type="nucleotide sequence ID" value="XM_066757669.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990025"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="140"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0249866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="542" mass="60504" checksum="CCA2D52436720366" modified="2025-10-08" version="1">MNFYKSAALALDHLDKHQGSVKGSLAAAGVKASGGEAKRILALIIETLKYRPVLQQLLKTVPILTLERITFPSRTPANTPTSQSLLLVLLHDLLFSSRSRIEASDKWPPKPAVMRHQARLKAELVKIQIREGKTKKEDLAKTSGEGEAVRYIRYNPNAGRSFIELEEYLEKKGYTKLDEPVYPVPDGKYFADPHLSDVLLAFPGSANWWVDDEWYEGGGVILQDKASCFPARVLMEGWVEGEGECLDATSAPGNKTSYVSALMANGGKLHAFERSPNRFKTLEKMLAKARCSNVQAQRADFTGSDPKSKEFRNVTRILLDPSCSGSGIVNRLDYLVDDDAQESDSKSERLEKLASFQLQMILHAFKFPSAQRIVYSTCSIHAEEDERVVMAALQSNIAKENGWGLAGRESVLPKWERRGRPEEMEGDEELSNGVIRCLPEDKTNGFFVSCFVRGDASIRPKTTKKSKDQRPPKRSLMEEDEETAEDGFPSVGGDDEGGEEDEGQDKLTVNVPRKEKTKAQLERAKRKKAQQKVKAKKRKVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTT1</accession>
    <name>A0ABR3BTT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614541.1">
        <property type="nucleotide sequence ID" value="XM_066757072.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989384"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="423"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="701"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="718"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="861" mass="95706" checksum="D3E50EE08271E2B9" modified="2025-10-08" version="1">MNQSSYEYLLDQPFPKSQPPELHFPSIACPRHTAPGSAYAPKPHPHLTSPVIYINSYPHDLPNGLLLDCLEGSPVKITLPPAVLPDVRLMPDVYYDWMPRSGTLEFNSLADAEKALTIINSHSMLAPRGVWVSPSPPNQTVSFPKSDIAERLIRPSKFSSLTRKPTQSVPKFAPSPSELYDAIRPWGSLKSVSTWLAGVAPENPATPDWFAKVEFWYADEAQRFETDFGQTGSLIKGWQVVIWGNTPVPFTDGILPCFAAPLQPPIITADIFAPGSYDPLAPAFFPSPFSEISHSSFPPITIPPLLTMQPFFPPTPPSISSSPPWATHNPFAYKSRSPPDPSQMLSSKSSVTSLRNNGSCLPLNSGPRRWSLTMGETPDGVFQPTGLVSDDGKIIQHGPGQHIRPAPAFGPGSQSASGLVDYSNIFVKNLDPDINSFFLEETFSQFGRVISARVMRDDHQRSRGYGFVSFYTPEEAACAVKAMNGTQFGRQVLSVTLHEPRKLRPEKIAERMAQGLIHRQAAPLHLARRSSSPIKSRRSFREMSTCDRSNNSERLDDIRLLSPESRKEALEKRLIARVRVYAKKRSVSEEMIQPIVNSLLPSDLALIPLLHNRTQLDNRIAETLFSIQEVPEMPAAAPRPTQRDIDDLCIQITKIDPDDVEHVMRILLDLLKMEDWEKVLGSKAEVAIKYGEAKRLLLKERSERKKESNDDVNNQDAVVDEPISETGLSEEPDVTIPLETITVPLLASLSAQEIVRNLSSLYGSRILLKLGVKAPSEQEKNSLLAWRTKAASKGKAIMRAEIVGMLERQAVDNGLKRSQRIKTLREFVNAEDDDESLCELVLYPALLNAKLECFISSRESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTX3</accession>
    <name>A0ABR3BTX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter NIPA-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614586.1">
        <property type="nucleotide sequence ID" value="XM_066757117.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989429"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF82">
        <property type="entry name" value="NIPA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="60910" checksum="0DE8DD947F122CD4" modified="2025-10-08" version="1">MATTPVSTDFGSVTASVTATLFDAIATSISSVSVGDTVYETQTLAGLNDTSLVNGGMGTSEAASDDSEGNYVLNTFIGLFIVLASSVLNALGLNMTKLDHVRQQSIPKRQRKKEYMRLLWLSGMGMYIASQVFGSPLALRYLRPDWVAPLGSSSLVFNFLFAYWLVGTPVTTSDIRGTAVIILGVILIIVFSSINHGLQQSLSIERLNSLWSRPAWLAYFIMSLLASRASFSPLASPSLELPTSRSSSPNPLVKSYKKLTGIWGKFERFAVGKLEVVFQRTDDAKVTWLQGIGWAVAGGSLAGLCLVFTKAVVKIMWLPGHPLVHPSALISLLLVILTAVLQIVCLNRAIVCADTVVVVPLFYAGYTVFGFVNSLVFYDEIKQYARWVLIVVFLSIAVLISGVVLLSLKSSANTSSDPYTVSAQPSGSMRLRPRTPKSEMDAGNNGEAAGPSAYLHKEEEDEEYEGVSGPGNVLWEVGSVSDHSGDEHEGEEERTGKGVGGVKGGTGERRGLLGEEEQDVHEGEDKEGEDKKGATRNPFDDEEDGFGEYEGVNVEEEQRTEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU01</accession>
    <name>A0ABR3BU01_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">A1 cistron-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614618.1">
        <property type="nucleotide sequence ID" value="XM_066757149.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989461"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="3">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="2">
        <location>
            <begin position="191"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="46154" checksum="6F320D1444B1944E" modified="2025-10-08" version="1">MDKLNAEQAQALWEAGGFLIITDLPEGSEFGIDGTFHTVRKFLGIKFLPPGLHFIAWSPPSSSTAGPSVIQIRQALVRNFSAKERYVIHYDNDTENVSLPENDTIMSDDHLKRLDNELAPYPFESFEAWKSLTSHVTPTISQSVIGTDGKVDGLMPVIDQEEDTLTRDMREKLEEIKRRSKIFGFTKSLMFVRFNLKKSWRDGAIGEEVTVYSKDKSWLLGNVIDEQLDRNPTALLGHLQLSFILFLHLSSYSSLLTYKRILALLCQSSSFLVSPSTFLSPPRLDPNAHVGEGTKTLYKELLKTLRVEIEALPDGVFDTELPEMDVFYLDQLENLRRNLAFAIWGEVEEGTACTEPERQSFKSLWNALRDSAWKKWKWDIDELGHRVDEEDEDEEGEYAPVIVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU16</accession>
    <name>A0ABR3BU16_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613785.1">
        <property type="nucleotide sequence ID" value="XM_066758383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990758"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045319532" evidence="1">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="93" mass="10679" checksum="82B040AFD8B0DC01" modified="2025-10-08" version="1">MLPTTFIFRLCLLLLFPLTLGLTLGAAIPRANHSPNLHLPANRLRSYQNNDDLPVRQAWLVKQAQVLRSKWILWVLTRGLKFPVQSIVDAIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU46</accession>
    <name>A0ABR3BU46_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="4">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613815.1">
        <property type="nucleotide sequence ID" value="XM_066758413.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990788"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="6">
        <location>
            <begin position="78"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="7">
        <location>
            <begin position="204"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="313" mass="32603" checksum="AE08340150BDE83C" modified="2025-10-08" version="1">MGYTLAVLGCGTMGVAILSGVISSLETRASLPRNPNASSQPPSGISTPTASQFFDAPEASLPSTFLATVGREETGRKLRRTFAEMGPIGKQVQVRAGQGNVETVDEADVILVCSKPQVARSILEEEGMSKALEGKLLISICAGVTISQLKSWVPATTRVVRAMPNTPCKIGEGMTVVTPLSDALSRTLILNIFTSCGRCRFLDEKHFDACTALAGSGPAFVALVLEAMADGGVMMGLPRSEALELAAQTMQGTGRMALQTGLHPAQLKDSVTTPGGCTIAGLLTLEDGRVRSTMARAIQVATNHASGLGQDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUL4</accession>
    <name>A0ABR3BUL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613683.1">
        <property type="nucleotide sequence ID" value="XM_066758281.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990656"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 8 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="301" mass="32697" checksum="DE8F8E6B4CD4CEFF" modified="2025-10-08" version="1">MNTLLQQVQQPSKLDAVAVAEDEFASSDPAAWGSMAGFGNLSRTGSVSGMSVPRVHDPTSFLDMHTDSMSANPEAKIKIAHGTTTLAFRFKGGIIVAVDSRATAGSYVASGTVKKVIEINKFLLGTMAGGAADCQYWETYLGMQCRLHELRNKERISVAAASKILSNIVYQYKGMGLSMGTMVCGWDKTGPCIFYVDDDGQRLKGDLFSVGSGSTFAYGVLDQGYKWDLSDEEAQELGRRSIVAAGHRDAYSGNTCNLYHVRQEGWEFIGNYDINELWYEYEGKKKAARQAAVGSPMAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUU3</accession>
    <name>A0ABR3BUU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytosolic Fe-S cluster assembly factor CFD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102896</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614900.1">
        <property type="nucleotide sequence ID" value="XM_066757431.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989752"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="331" mass="35475" checksum="73CF630F8308DB73" modified="2025-10-08" version="1">MADIIETPVSRRLSSVKNIIIVLSGKGGVGKSSSSVQLALSLLAQSPTNRVGLIDLDITGPSLPRMVGLDTPTATVHQSSAGWVPVYVDQGRRLGVMSIGFLLKDRGDSVVWRGPKKDGMIRQFLSEVRWGDLDYLIIDTPPGTSDEHISLVTHLHPLFTPTVSNPTTPTSILISTPQTTALNDTLKSLSFTRKLSLPVMGLVENMAGYVCPCCGEISDTFGKGGGETMAQREGVGFLGRVPIDTVLVSLLDAVSKGEVLGEGAVEHSSDEATEGQTNGSTEHFPLLDKYLETASSKVWKDITRKLVDKVEQRKLDIHANLESSSEKPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUY1</accession>
    <name>A0ABR3BUY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614683.1">
        <property type="nucleotide sequence ID" value="XM_066757214.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989530"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="60"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="484" mass="53479" checksum="B7D09F42B21C8271" modified="2025-10-08" version="1">MSAFATATTNKAEDCSSEVGMSEKGVESPEIKDVGDIEVQVASIDRTVERRMLKKQDFGLLPVLAIVYLFNALDKGNLSNAKTDGLDKDLGLVGNQYYLMITVFYIPLCLCGTPLSIAAKRFSAARVIPLMMIGFGSCSLLSACVTNFGGLFALRFLLGIFESPMLPSVVFYLSQFYTRGELARRVGVFYAASSISGAFSGLLAFGIFQIKSERLHGWQYLFLIEGAGTVTFAIFAFFWLPRSPATCWFFNEEEKKTSRMRMLRDGTNEIGEKVDFRDAFMPFINDWRYIVWALLALGLGVPLASVGNFLPQIVARLGYSTVKTNLYTVAPNIVGTCFLVLFTQSSDYFRERALHIVVPLIITMVGFVILGTIDVLSYKGVAYFACFLLCIGANTPSVLLSTCGLISANIFRAQDEPKYIPALAASAAFGGFTALLAFSFGLYMRIENRRRNFAQGLPKSYGSKDVPTEYLGRGPKDQAFRYMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV32</accession>
    <name>A0ABR3BV32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division control protein 73 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614145.1">
        <property type="nucleotide sequence ID" value="XM_066757761.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990117"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="6">
        <location>
            <begin position="252"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0249958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="418" mass="46231" checksum="E9DED484771AFCB2" modified="2025-10-08" version="1">MASNDPLDLLKSSLQSSNAPQLLTAASEPAPSLALAAYLSFTSTANPINLPKDTPTRYTSKPGSTSEFYNIGQLYLAWVERDSGVRDYLIKGQAGGVGYVAITDRRPAVDYLLGKGDGEGRIAAKGEEGAKQQPAGDSAASATAEALPSALVPSTEAGPSRVSTQAKRKYEVDVVDREFCRKLRSEEIELRDRNSVLRSSAGGKANNFEAFQRNVIHEKIKTLRTSFEKGGKQPAAVAASQSDLNRAKKARSTNPIIVISSSPTSLITMWNVKKFLEQGVFEPSETVRQREASQGNIKAEDMIPVIRKRSGPHGDVTSKYYIVDSADALQKFGQDAWDRVVCVVTTGQTWQFKPYKWDDPKVLFQNVKGIYFQWGNDPVNPTVKDWNVTEMKIDRNKRHTDRQVVADFWRILDNAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV77</accession>
    <name>A0ABR3BV77_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Integral membrane protein S linking to the trans Golgi network-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101692</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615023.1">
        <property type="nucleotide sequence ID" value="XM_066756246.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988550"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29727" checksum="67287CD531F531AD" modified="2025-10-08" version="1">MRVQGWDPLLIICQIITLQTIHYLTLSTLLPPFLTTLTSTETLTYSGGPSTVSHVMDWREMAARPTVNKGTFPGVEGWKKLRGAWAGGKWIGKVKGEAQVEGEKEEEGEKEEIWDYGVDKKRGWVIAGTWMLAFAIDILPLYFIIRRPTHILDFALTLIFNHFILTTYYSASFPTSIFYWLVQACGAVIMVVSAEALCVRREMKSALEIGWTPDPEVGLPLFEDQPDVNGDVSNVPRAGPSTNSVKQPERVEPAEEIELQELQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVJ2</accession>
    <name>A0ABR3BVJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615108.1">
        <property type="nucleotide sequence ID" value="XM_066756331.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988637"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="79"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="214" mass="23370" checksum="CFD1D9BC477F1919" modified="2025-10-08" version="1">MSVRAPLAAIRRLATSARRLQDAPAPPAPAPPPPPSGFTAIRDLTSPSAFTPPPAPAPPAQRPARGYRPDCLPPPLDPTLDLLTNCLMKHGKKSDAQKMVHNILALLQGSTHLPPQPLLRQSILLASPSIKILSMRKSAKTILTPRALNERQRTRQGIAWILKAAEKGRKGGVSRDQRIAKEVLAVLEGQSEVFKWLEDVHKVGYLNRSNMNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVJ7</accession>
    <name>A0ABR3BVJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Multifunctional methyltransferase subunit TRM112</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRM112 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615137.1">
        <property type="nucleotide sequence ID" value="XM_066756360.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988666"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21089">
        <property type="entry name" value="Trm112-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14087" checksum="03609C0D8596E978" modified="2025-10-08" version="1">MVRLITHNMLACHVKNCTKDNFPLVFSEVELIERPAPINPDFIKRFLPKLDWKALVDTARSLGDTSLPDTMPENWTDEEIQALHHVLFELHVEEGIMTCRGCGHAYPVSNGIPNMLLAEHEVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVU2</accession>
    <name>A0ABR3BVU2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA phosphodiesterase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3'-5' RNA exonuclease USB1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615132.1">
        <property type="nucleotide sequence ID" value="XM_066756355.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988661"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="280" mass="30690" checksum="2D32C7A59B6AFB7D" modified="2025-10-08" version="1">MALVDYGSSSDDEEGHVPQRLATPAKKQKKLPILPSNFNTTPEDDPSLHQGRTRSRPYVDGEYNTHVYISLSVSLELSKILKTIIAKLPSSPSPIHALLPNLHISLTRPVPLRRHQIQPFRDELASRLGQTCAFKLSLVGSVNPYYNEVTGGGSNRAFLALRVGAGASELKKIVDGVLDPTLKELHLPTYHDDPEFHTSFAWTLFSTKTDGQDTPRGVLPASDGQSVKAPGLPFDKKDLDKVNSIFESKILKAQPRGGWTISSVEVKVAKEITTIPLKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVZ6</accession>
    <name>A0ABR3BVZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615289.1">
        <property type="nucleotide sequence ID" value="XM_066756512.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988819"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="158"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="429" mass="48245" checksum="3E84EBEE7A06D3F7" modified="2025-10-08" version="1">MPKDKKIQNAFKRSEVHRKTKRAKEQAKLQRRLEIKKAEKDKVTGAALRAERLSKNIPVTIDNTRVYDSSSYLTANPASLQNLAQKAEEASALVNGGKKSAEVLSNGEEECADFRSSSDQQEDVDGSSEVSDQEIEDEMDEEDQEGPARQGMTIQPPPRILITTSPSPCKQTYQFCDDLKNVFPGGEFFKRPKGKGFEIGRVSRWASKRGYGALIVVNEDHKIPNAVTLINLPSGPTAYFKLSSITLSSNIYGHARATPHSPELILNNFTTLLGNSVGRLFGSLFPPQPQFRGRQVVTLHNQRDFLFFRRHRYMFSSATSAKLQEIGPRFTLKLRWLRKGLPSVTAPDGHVSVGGDPEDDIYGADVGPSSEEIAQEEKDEEDEALKEIGHPVQKKNAYEETEVPALDEEQEYEWKWKPKMEVSRRTFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW35</accession>
    <name>A0ABR3BW35_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Pyruvate kinase</fullName>
            <ecNumber evidence="4 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_101988</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 14"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615316.1">
        <property type="nucleotide sequence ID" value="XM_066756539.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988846"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 14 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="16">
        <location>
            <begin position="53"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="17">
        <location>
            <begin position="414"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0252596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="552" mass="59481" checksum="31962C928D8D8860" modified="2025-10-08" version="1">MTLGHYAPQSHTTVPPPPHPSSNMAGTPSSQLAWLSGLSTSFNEMSAEQKFLRKTSIIATIGPKTNNVETLVQLADAGMNIVRMNFSHGSYEYHQSVIDNARAAAAKSPSGRPIAIALDTKGPEIRTGLMKDDTDVPIPAGHEFWVTTDKAYAEAGTAEHIFIDYANIVKVTAPGKLIYVDDGILSLQVISIDGEKLRVKSLNSGVLSSRKGVNLPKTAVDLPALSEKDKSDLAFGVKNGVDMIFASFIRSANDVKEIRKVLGPEGADIKIIVKIENEQGVMNFDEILRETDGVMVARGDLGIEIPASQVFMAQKMMIAKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVIDGADCVMLSGETAKGKYPIEAVKMMAETAFLAESSIAYPPLFDQLRALTPRPTETAETLALSAVAAAIEQDAGAIIVLSTSGVSARLISKYRPACPIICVTRNEQTARQLHLSRGVYPVWFPEPRGIPAEKWQIDVDNRIRYGLRVALGLGIIKPEATVMAVQGWKGGLGHTNTLRILSVPSDPADLDLHSIERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW73</accession>
    <name>A0ABR3BW73_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102012</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615340.1">
        <property type="nucleotide sequence ID" value="XM_066756563.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988870"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="550" mass="60016" checksum="13D6F4C7D278501B" modified="2025-10-08" version="1">MNDDILTKAVLPDNELKDGEKKAVDFGEGKVLLSKINGRVYSTSAFCTHYGAPLEKGVLSHDGRLVCPWHGACFNVCSGDVEDAPGLDSLWSFSTIVQNGQIVVSASKKEVTSKVGRIVARKRTKDQEQKQGQVNEETVVIVGGGSGGIHTIESLRMNGYEGKIVMISAENYAPIDRTKMSKTLLDDVQKLQWRTPDELRDSFGVDFHPSTSVTKVDFEAQTVTDSSGSVYKYNHLVLSPGARPKKIPIPGADLKGVVTLRHVEDTKTITSSITKDSEVVLIGTSFISMEAASAVLKKGPKSVTLVGMDEVPFQGLLGKEFGSALMEHMKGQGIKFHMSAQIEKITASETDPNHVGLLHVKGSDPIPANLIIMGTGVSPATSFLEGSVKLEDDGGVLVDEYLRLKGFKNVYAIGDIAHYIQYPDKFPRRVEHWNVASNHGREVGHNITHPDNLVAYTKVPIFWSSIGKGLRYLGTGAGYDDMYVDGNFKELKFAAYQAKEGKVTAVAAMQRDPIVSKASELMRLDLMPPLEEIKNGKDILQIELINKTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW89</accession>
    <name>A0ABR3BW89_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615361.1">
        <property type="nucleotide sequence ID" value="XM_066756584.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988891"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07600">
        <property type="entry name" value="BAR_Gvp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0252641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33294" checksum="7DC3F251A636C58B" modified="2025-10-08" version="1">MQAFRNFQAQIPALPPVDVSAVSKSFRQTVQATRERIGNVGPEGITELPAEYKQLEARVDALRDVHNKMLKITKVHERESYDYPSDITEGISEVGHQAASAWSTFANKNLKNTNLPIPIPSPTAPTPHEPKTLPHALSRAAKSGATELGAEDRLGVALGIYGAALEKVGDARISQDQLITERFVTPWQATLSTSIGLAMKARQNVKTSRLELDAARAALKSAAPAKQEQARLHVEEAEDKLVQNTETAIGLMKAVLENPEPLQNLSNLVKAQLIYFSTAAETLSGIQGQIEEAATVAESDYRQSRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWE4</accession>
    <name>A0ABR3BWE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="8">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102596</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="8"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614610.1">
        <property type="nucleotide sequence ID" value="XM_066757141.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989453"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="330" mass="35908" checksum="6C376EC516EE14AE" modified="2025-10-08" version="1">MSHTAHFQVPPLQISSVLHGGIHHPTLRTWQANGRNLTKSMLIYPIFISDDPDAEQEVVTLPGQKRWGLNKLEGFLKPLVEKGLKSVILFGVPTTMEKDPRGSAADDESTPVIQALKLLTNLFPQLMLCVDVCLSHSNAPTLDAEASAQRIAEVAVAYAKAGAHCVAPSDMMDGRIRAIKYGLMQVGLANRCALMSYSAKFASGLYGPFRDAAGSAPSFGNRKCYQLPPNARSLARRAIQRDAGEGADILMVKPALPYLDIISDCAQYAPDHPTACYQVSGEYAMVVAGAEKGIYDLKEMAFETTESMVRAGASIILTYFTPQFLDWLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWF3</accession>
    <name>A0ABR3BWF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615439.1">
        <property type="nucleotide sequence ID" value="XM_066756662.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988969"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0252719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="70" mass="7443" checksum="C420AC927DF672CE" modified="2025-10-08" version="1">MVLNEPAMTGGLRNGGGMDGSKVGIMWDNGDVARCTSTSWVLGSFLSFNPPFSATKSNKGCRPYKLAIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWR3</accession>
    <name>A0ABR3BWR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615294.1">
        <property type="nucleotide sequence ID" value="XM_066756517.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988824"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="34824" checksum="D915C62B6EAB27B9" modified="2025-10-08" version="1">MSATEQVNQAPAETTNVVIPEATPSSEEAKKMLKAEKPVSETAAPNITEPVVEEQPIIADTEAGTGHSGPELARKAENTEADKHVEGTKTEEGAKTTEELPKVVKTKEDKKDVKKSAAKEKTEKTKAEGKGFFAKFFGNKDKSPKKEKKKTPKTEKADPVIAAAPIETKDGGDAVPQSVSTATEPAIDSAPPTEAVEPAVESPETAAPTGIDTATAPTDAPAEAAPVPEENKIAEKKDEVKDHAGKPNLKAHRRLSARIGDIFKPKKKEDVSSPKEEISKEEATAPLNEEAPAVASEAPKLEEPVATEPLNLEEEPKTAPPPAAAPVAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX20</accession>
    <name>A0ABR3BX20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615647.1">
        <property type="nucleotide sequence ID" value="XM_066756870.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989178"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019488">
        <property type="entry name" value="Nucl_pore_RNA_shuttling_Mtr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10429">
        <property type="entry name" value="Mtr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="2">
        <location>
            <begin position="39"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="178" mass="19433" checksum="8055D8C9F44E1966" modified="2025-10-08" version="1">MASITPSTIPPSSQSGIPTTVPPGAQSWGPLAIDAAAHGAIAFCQIYYEAYDEPSRRAEEIPILYLPSSKIIWNGNPISSEPTAFAEFLRSMPLSRHDLQTLDCHPVASEEGSAPSLIINVTGSVLHGPAVLQSSNDKPQERDMPRKFHEMFMLKVIGQEEGMQPRYAVHSSNFRFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXG8</accession>
    <name>A0ABR3BXG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614733.1">
        <property type="nucleotide sequence ID" value="XM_066757264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989580"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="25"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1419"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1425"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1486"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1525"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1547"/>
            <end position="1562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1730" mass="193237" checksum="D6C370186DE3FB97" modified="2025-10-08" version="1">MPPLTKEELWSSGQDEDVEVNQRALIDKILARYSGEHTIFRELLQNSDDAGAQHVQVKFYTEDGLEALKSGQEPSKLPDAKTALIHSYVVSNDGIPFRVEDWQRLKKIAEGNPDEEKIGAFGVGFYSLFSVCDGPFVESGDKWMAFHWKDGKDKLLARSGHLPKSVDNLSSLSGNPWTTFSMALREPSLLEGPLELARFFVTSITFMRTVKKIEMLVDGISVLEVEKVVKRKEKAERGGLNTMAAGGMMTVTSVDVTDMVITAKVMKWLEAAGFSPPHLPSTISQFAKPARGLASMISSSFFGRYTSSSTPPPSSTVRDPPSTIENAKEITTFYRDILIYQGNVKVNVTPAFARELERATKKPAPDRMPASIVYSRGTDDDETKDLNGKPFKKDVAGVFDGLCPKLDSDMSAKVFIGQPTGQTTGIGGHVASRFIPTVERESIDLVNKHVSHWNRQLLWVAGFLCRLIYELEMQGIADEWVKITKTDELGLSRLTARALHVIRFFNFRPTTPSTVVGQEMEASFYGCSKNNQLFPILSEQGVQSVKNVRMPQASISKFLPELPVISSAVLDQAIRLTGQLHAQRLLVDISYDDVVKQLGKRPLTEGEAVDCLKWWEDMASIEGFNLSLRNRLLDAAIVLRDDGKILPLSMVQTFIRPHSGTISSDMPIPQHTIPYSITKNLRANSISRIFGWTELNLLQYISFLTNPPMSKPATDPSTDIRSSPEFSEKVLAMLGRAWPNLPSNTQTAITLELKDVECIPTKMGMKKARETYFEGNLLFDDLPIIALPKGTALRGSMEKMLLAIGVRKTVDLQLVFSRLIGGGTWSCQDLMRYLVSVKDTLSDEEIKRLRQTAAFPLLVEHPEEGKELHPVRQKPWQLYEPTEAMKSLGLPVLDWGNGKWRSNSDEAKLLFTLGLNRYPPVDTLLKIAAGRAPLNQKALEYLLSNHRYHYPTFKSDAYPDIAFIPAINTRGINVLAKPGEVFTNPECAMLGFAVAQPYVASPENAAKLGIQKDPPLQQLVIALINNVTVDVKAARKIFEYIGTFIGHATPSSVDPLRHTAFIPVQKGADPSSVVLFKPPQVYFVSGDSEDDLYSSAFTFVDFGLKANMFLRYCGVKSEPSIKDITLLLMKDSEGMLRQAGSSERYLEQLRLVAANWNRLDNQTRSAMKAASFLLASQRIPVSKKTLSMVAQPVNGGDDEYYREWVLCRASEVVLVDRVAYAQYFGQYILSAPEERILEDFYLELGAKPLSSLVESKYISTPLRNHSASDKALALRQHVLERLAIFLSDRRKSALYTVEELAREDKFRVEEVQSLKVQHLYRKGNKEHIHLQSLYAFASTGKGKSITLTISVTAEPDYYDVASALCEVLFKSQKADEALLLFSILTTPLLALRKRGFNVDRILNQQREEKLRLQAETRKIKEATGPQEQGQTEVTIQNKDNSARRASVSGESYGVKGLFNKLSRGSSRVKEKEMEMPGGMLGGLPESTVQRVAKQNQTSTGGTSEDLMDGNKSSGVTRETRHGRSTKNPTDLSNIRATVKKAMDASRPETSTQIRDSRQAVNDVSESQNDYCNTSVHVDLVIAFDASPNSGMPLQIWCPRDVDDPNDFLRDKMEICVRFARDVLVPICQVFLLRPAVINIFWDHEGPTIAFNRGGAVFCNARYFAAWHNDMCIRGQHKEPWISWYFSIAHELAHNLESAHNASHEFYFSSIAEQYLLSLAALLQNRTSFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXN9</accession>
    <name>A0ABR3BXN9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615609.1">
        <property type="nucleotide sequence ID" value="XM_066756832.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989139"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32962" checksum="0C0C4927E3661C57" modified="2025-10-08" version="1">MPKDPQQVIRLMAPFSMRCNRCGEYIYKGKKFNARKETAVGEEYYGIKVFRFYIKCPMCSSEITFKTDPKNADYTCEQGATRNFENWIENDPNGKAGAMPDAAADDDYDSDGNLREEAQERDAMADLERSQEQSKREMELMDELADLRQRNARVELNKTDQDPESLLAALHAEKISAEEEARRKAEQEEDDALVRQYFAKVAGPAGSDAQKSEKTESPDGEAEHTEGVNTALPQLTVKRRPVPGTGKAGEPSVQSLLAAKGKVLETAGANGPGAPPQVKRKREGMQKLLGIKKKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYZ6</accession>
    <name>A0ABR3BYZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615839.1">
        <property type="nucleotide sequence ID" value="XM_066755553.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987851"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="5">
        <location>
            <begin position="52"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="856" mass="95588" checksum="C761B09DFCDA703C" modified="2025-10-08" version="1">MSRRDVDEAALLKFYGIYTPYPEHWEEVDHEKDGPLAGTGTLGEDGGASEISDPLGLRGKLTGVTDLDIKTRAATSLSSKTFDPKIFLSAHHPDASYQDLRKGINNLERAIESRSEAVRILVEDNFDRFVAVKASSDVVYRDMKEGFLADESDHGTRELREIFKVAAHRADQVFLPVLENAVKASKLRSTLGVFEKSKFLFNLPGQLLESINAGKYELALRDYKKGLFLHNTRSGQLIPGVNASREQQKKVFDKVWSSVEEIMSDMRAKLDSGLKEAARGVEEQERTIEILVELDQSDEPAWTYLDYQHAHILSTMKIIYEKAQESARIAGQECTREPSSSTAYLNLLTRQLSSPQYQLNSLAPTTVDAAWLAIHYLVKRLSEYVTKSFAGFWRIGKACMDGKFRKRDSSDNIAASNRPANTCRIMALEILKLYSSLLSQFFKLSDPAVAESTSRKDGRHQLPSFVPAGTTVITACYFAEKLAEYVSDCAGELAVHEVANDSGNSMKGLIESMKWKMQEVIGAAWARDAKILHGLEDWSQATNPKGAIRYLTVVDEFQLRITSSVKKIAATSQGDKESFSNSLKKRIREDFVETQCYIYDGIMKATDVDLRDESGDVEQRRRPLRRTSTDVSVVQNPEIRLLVSLAKFNQMQGTSIKAICREVGKVLDVDMAKQQDLLLQVIEGMDTQAFKAYINLRAEPLSKIIGETLLHDTDWVNAGKPTEIRPYVHKIILLLVEAHAQTGDIAPALVPRVIQALIEVVANVALSCFQQIKKYGPGGMLTATVEIEYFHSVVSLYVSSQANDNFSQIYDTIGSVYGRQQSPEELSKEMDGLRKLLSATRKATGMETLCLRAPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ24</accession>
    <name>A0ABR3BZ24_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spp2/MOS2 G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615864.1">
        <property type="nucleotide sequence ID" value="XM_066755578.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987876"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spp2/MOS2 G-patch" evidence="5">
        <location>
            <begin position="227"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="444" mass="50334" checksum="AA6C764BD9CF562B" modified="2025-10-08" version="1">MPAPVSFTVRPPGSAPYRPSPLGSGARGPPSQRLFEDNRDEDDDEDDGYYNVRRSQKPKDERIEGFGNGRIIGGDKPEGPLIIPALPNRDWRASSSNRRAPSYRPDSRTPTEPVETHERVGDEPQRSGLRSIVKTEVQADDGEAAVKVERTEEYETPASLNGTSEAGIKVKKEPLTLEEQALQAILQGDVPTETEEERLRRELVIDMGGNKSLSEEDALKRDIETLPEESTLDDYAAIPVSAFGEAMARGMGWNPSAQDTKIHEPKLRPALLGLGATALETPVPPSRPGSSTGKRPAKPSKRDSMKYNLSGALVKRGENGGSVTPGSERSSRHSAESDGKRRRDDDDGRESKRRDDGYRDRDRERGRRDDRARDRAYETEEERARRKAKERERRDRYDDRDRYGDRDRKDRDRRDERERRSYTDRGDDRDKRDREGDRNGRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZE2</accession>
    <name>A0ABR3BZE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615770.1">
        <property type="nucleotide sequence ID" value="XM_066755484.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987780"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31804:SF2">
        <property type="entry name" value="CUE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31804">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="78646" checksum="1839AC3A239F5E6D" modified="2025-10-08" version="1">MSESSVKKRPSTEMGGRDPKRAKHAEAGNGDNGASASAGAGAGAGAGVSSEPDLLKGVEKLYSQVVIQAALIFQYMDYARRIGLKNTKVPVHLQQQLELSWRAYESLRTRIHWDDSKGDRPKALSSTPPLPLPRSVTLATSIPTPPIPPLPLKSSTSACPSTSSSLQALKISAQAPLPIPPHLREKHDGPQSQAHTQMAPLASPIPLGAASSLAFDGQALQEAPPVPPPSLSGTVSSSIAIPADGTTVTAGGSAGTGAGAGEGAVDFSSLGFNELNQLINGDPTPFGIHLDGTSSASTQINNQNQPQQGQALGLGLGQVQGQGQSQAQAQTQGKAQGQEGIAQKRTEVIDLTLDDEAVDMSKSQSQSQLATQLPAQNQTQTQNQNQKQPEPEPSSLADDVLASLGFSTDLNLTINQDQPASLPPFTNQGAQNAADGGKGPLDFGLNTEHDFSALAGLFQGSNGTPGAGTGVGFGMGMGLGVGVGMGEGDSNPASNAATAGADDTRPVTDTNPATETDNSNTGAGASAGADTSGIDTTTKPGQQGPAKQEDTFEDLFAAADDIISTMRPEDDIPRPEAESAAETKTAQAEPQAKPQTESQFQSNQTLSNQNQNQNQPQSQSQSQNQNQNTNKNKNKDQTPTTTSTSASIPPTDQTPNFMLGNIGNMGGMDSMGNLTNNLGGMDNLGGIGMGNNMDNLDLNLGSMGGMSMSGMDDFAGMGGMGGMDSNGFGDLGGIDMSDFNFGDAGGDGNGGGAIDTEEFDRLMAEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZR2</accession>
    <name>A0ABR3BZR2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615890.1">
        <property type="nucleotide sequence ID" value="XM_066755604.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987903"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16166" checksum="51F9A3C437AAF2FB" modified="2025-10-08" version="1">MACLKFMQNVWQKTLSKGGHDANVLFSLRLLEARPGYIKGALTINAKHLNNHSTIHGGVILTLTDTITSLSLSTHGLLAPTGVSVDIMEQLGRTLAYTRCEFYTPPGGERGNKLVAYGAQTKFMGGAKPVTKFSADGETELSLENTEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZR3</accession>
    <name>A0ABR3BZR3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616043.1">
        <property type="nucleotide sequence ID" value="XM_066755757.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988058"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="254" mass="27518" checksum="74EDE31D59248AD0" modified="2025-10-08" version="1">MLNLSIFRPATSRPRLALSLPTFLAPKTPTQGVQQVRFRGQLAPKRTKYRKASKGAPGTQIPTGGSLKGTALHHGTFGLRACSSVRLSAAQLTSCQAAVRRKIKPIKGAQFYLRVFPDIPVCVKGNEQRMGKGKGSFEYWSCRVKPGKVIMEIGGGDIREEIAKAALKLAQARLPLQTEFITLSSPPRLGRIATPALADPPAAQPIPNNLAYLDAKEEGGARRVIMRREERAVEEIVDGLRGLEMKDAAKGIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0A4</accession>
    <name>A0ABR3C0A4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616287.1">
        <property type="nucleotide sequence ID" value="XM_066756001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988303"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="296" mass="32928" checksum="87CDB31FAB755B5B" modified="2025-10-08" version="1">MPSNPSLEAVSAANATKRKNAPRDDEDSASESGSDVSMINVDFDFYNLNPDVDLIAVKRLLRQTLSYDEERINVHPLAELLLAEGVRLQAGSSIKTDGEESDPWGLVTVIDIVKHMDHPALKPFLEYLCSTLANNSNSPLQSIFNFSSPNIRPALVFSLRMLNLPLPLIPHLYRMLLEELEVKEEGRFTHFIVWGRGYKLEGSEEGMGLDMNIVEKSSKKKKASGNETVALSAGSFPYHPEEEFMDKIANQVHTYNFKTAAPRDAESFGVEQFGRLVLLEKAKLVSAIQSMQAACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0D0</accession>
    <name>A0ABR3C0D0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616314.1">
        <property type="nucleotide sequence ID" value="XM_066756028.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988330"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="322" mass="35335" checksum="BEF19E556F87BD26" modified="2025-10-08" version="1">MSSHASTPSTTVAVCQIRSTSDPVHNLKISEKVVRSAVAAGAKACFLPEASDFINPSKAESRMFSRPLQEHEYTIGLQVLAKELAVVISVGVHEGPEDENEERVYNTHVLIGKDGDILASYRKIHLFDVELSKPPAPDGSPRPPQRTGESERILAGQAVTPPVEVEGIGKIGLEICYDIRFPELSIILTRLGAEVLLFPSAFTVKTGRDHWGTLCRATAIQYQSYLIASAQYGAHNAKRTSWGETLAFDPWGRQLGRLRSVDDTPPPKEGEEGDKDVEKMYEDSGEFFLCEIDGRTVKETRGQIPLAMQKRSDVYGVVGKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0M0</accession>
    <name>A0ABR3C0M0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_101086</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615931.1">
        <property type="nucleotide sequence ID" value="XM_066755645.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987944"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="15">
        <location>
            <begin position="364"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0253710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="715" mass="77054" checksum="9DEF4580EEBF23BA" modified="2025-10-08" version="1">MAEQLKQVYANKKAQDQAAFVTFLTAGFPTRDATVPLMLALEAGGADIIELGVPFSDPVADGPVIQKANNVAIGNNVHYSDCLEYVRQARAQGLKAPVLFMGYYNPIIAYGEEKAVKDAREAGANGYIIVDLPPTEAVDFRNTCTKAGMSYIPLVAPSTSIDRVKFLTSIADSFIYVVSKMGVTGSSSTENISASLPELVKRIQMFTTIPLAVGFGIDNRTHFDYVTASGADAVVVGSKIIKLIFEHADDGLAPKVVEDYCREITLKGQNPPPLGRKNAAAPPPANGGTVSPPLPIPSGASLNESEVKVTAPGKLPSRFGLFGGAYVAESLVDCLNELETAYAEAKEDPAFWKEFEDMFGYINRPSELYLAERLTEEMGGARIWLKREDLNHTGSHKINNAVGQILLAKRLGKRRIIAETGAGQHGVATATVCAKFGMECDIFMGAEDVRRQELNVFRIKMLGGRVIPVTSGSQTLKDAVNEALRDWVTRVDTTHYLIGSAIGPHPFPTIVRDFQRVIGREIKSQMHEKMGKLPDAVVACVGGGSNAIGTFYDFIEDPSVRLVGVEAGGHGIDTEAHSATLTKGVMGVVHGFSSYIIQSKEGQLVPTHSISAGLDYNSVGPEHSHLKYSGRAEYVVADDLQCLTAFKMCTQLEGIIPALESSHALWGGMQLAKSLPKDKDIVICLSGNGAKDVAEVLLTLKDKEWADKLDWHVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0N7</accession>
    <name>A0ABR3C0N7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616409.1">
        <property type="nucleotide sequence ID" value="XM_066756123.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988426"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="395"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="578"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0254188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="685" mass="72881" checksum="B347CDB4119233F5" modified="2025-10-08" version="1">MSASSVVPAPVPMPMHMHGWYSSHWANGRMAPPSNAPVSPQASAPVASLVNKAGQLDRGHSPFQRLHQQKISAEQHLESSAPMTVSISQTTLQMRASFIKMNAVDTVLRKGFASRRYVGSDGQATVTVVKQESDLPHTSQSLPQQSNPYPCNSVSVYVQASIPVEVSGRYDSPEFAFSPRPSPQHSFFISNCINPSPSSKASKAPMPGQRQSAETRTEWSSVQAKVEDSPYEQAPVSPLPAPMAQQSAEVPAQGVYYSTGGEMPTLNGLTGDGEGWTNGDGGAGDVGGSGNGGGGDGGMGQDGSGIGSGGSGNGDDGDNKGRGNGAGGKGKKLALACHFCRRRKLKCDGRKPLCETCAKRGEVCTWDEAVRRRGPGKATKERREKAAREAMAAGLTNANSIGARSSSSGAGPSSLSIPLGDPSQGLGASTGVDIPEGLDPHLGLEEGHHAHHQHHHPGQVNDAHDHVEHHNLDQQGEHHVHDTQGHEHDALQHQLDLDIDPTLIALSAVMPETLAELEKVRENHEHAQAQTHVHTHEHGHEHHTRREQENGHEDLNGDEQQERDTRAALAHLQAHSEFPPHAPELVHDESGNQGAPEEEEVEEFHGISDIPEAGILTDEISSAAVPEEGSTEEGFVAGQKRSAEVDVQGENEGVKRFKVEDGRETMNVVGNAGSLEHVGGEEQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0S7</accession>
    <name>A0ABR3C0S7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribosome biogenesis protein ENP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616444.1">
        <property type="nucleotide sequence ID" value="XM_066756158.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988462"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="9">
        <location>
            <begin position="15"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="8">
        <location>
            <begin position="410"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="7">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="581"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0254223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="771" mass="85437" checksum="85EFB0D146ED7EFE" modified="2025-10-08" version="1">MVAFPKVYTVNGPSSTSAASLPSWLAVKAKPTGPGKHKKRTKTQHQIGDLELIQDFTFPGSSIKIKTTEDGQHAIATGTYKPMMKVWDLEALTVKFERVTDAENVDFVILSSDWTKTLHLQRDRSLQLHTQMGLHHTIRLPIYGRSLAYHSPSADALVGCTGNEVFRFNLEEGRYMTPLRVAQGWGDGNEDDVEGVNVVDVNPRHGLWSFGLDGGGGVVEFWDPRSRSALTRLVLPSSTLLPAHAFDQDSVLAPAQKLSITALASHPTDGLSLAVGTSTGHTLLYDLRSPTPFAVKDQGYSEPIRRVDWLRGGGAHEDAGRVVSADRKVIKIWDKNQPSENQLSLYPPNSLVDLHPVPQSGLMLVACDAPQLSSYYIPDIGPAPKWASFLDSVTEELADDYIDGAGKSAYADYKFVDKAELETLGLTHLIGTPALKPYMHGYFLSLKLYTTARLIANPQSYSEYRDRIVNEKLKAKSESRIRARKDQPKVNKALAERVRRAEEREKALERKKKERRGLAEAEGEEMEEDEEGGAAPGLLQDPRFKELWENPEFEVDEESREFALLNPATANNNAKRKTAVEEEEDESDRMSSDLEEEQESEEESELEQDEGSESDESDDGNLLQYDPRQLAPSQRRPMPRGKPTLVVGGSQPTSLPTFGQRLHSQPKSASSKISAEQDPSILATRRAADGGMEMSFIPSSKPRSGGRGGGSDGEDDQDEYSGGTRRRDRVERFGAGMEKGHLEDDELEGRGGRMQRRRPGRSASKNAFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0T1</accession>
    <name>A0ABR3C0T1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616461.1">
        <property type="nucleotide sequence ID" value="XM_066756175.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988479"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0254240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="86" mass="8954" checksum="3869DACFFF46FE4D" modified="2025-10-08" version="1">MGLCCSRHHQPVVVAAGPPVVVRPMGMGMGMGMVRPGFGMRPNVVVVQQPRRHHGGYGGPRYGYGGPGGRPGGGGGYGRPGGRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1D3</accession>
    <name>A0ABR3C1D3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615802.1">
        <property type="nucleotide sequence ID" value="XM_066755516.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987812"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="34688" checksum="A51BFA3746AEB281" modified="2025-10-08" version="1">MPLRRSRPTHGAVPNDDILTLSLSEVKERLARNTALLNSPLFAQPTPPSASGSTSKVQEAGQEPSDPVKEKLVKAREALLMREQELMLQNMNIGASSSPEASNAAGDKKGKGRESVGGVSGKQRVLESIRAGEGALAKNGLILPMDQTLSLGQRDYINSTTNALSSLTLDHHTRSSSPKPRNSTRTNGVPRSRPSRSQLLASGNVSDSIGGFGGDEVARAERLARLSAFMSYKGSDDEWSDSDEEEDEGYYDYPEDGQGEMVFETMDDNQIGYKPNGMPLRRKNATGEEVDEYGMEDDDFAEGNSDYENGAGDEPTSGAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C2B7</accession>
    <name>A0ABR3C2B7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615910.1">
        <property type="nucleotide sequence ID" value="XM_066755624.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987923"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="286"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="439" mass="48052" checksum="B982175B0E500680" modified="2025-10-08" version="1">MEEKPLSPRVHHLLIREQRSNELTGIGLRPILTDRSGSRAHLSHNAPSPNTPMSPLGANADITTSPYSQSQHKSVRRSVSPSQKSFQPSSEAIPLPNRRTNSILSLLNGPMSSSPPSCAGPSSSFTSKVEQDKHHRHRASSPHPPRPPPATFPIIEHNQSTYFEEWSRLPPTPGPMETCNPAPPSFSEFHPYHGPTAPYMPHVIKRPGIYRRHSSHSNEHHSLYPLPIHPSLYRHSAPHPFSVTPSTGFNVPLPPPPPLTAYANGPYEPDFRASGIRAPISRTTKACNGCRNRKVRCDAGAANGGRAGETPCTRCKESDLECVYTNVQKKRGPCPGTARPTASRSRRSSAQKQQQKAPTSQPPLPPSRLDCSWTDQSNYLNSVSPSQRSSIASIQTPTDLITPEETTFGYVGTHGFPFPTGQHVGPRGSYSAAPWEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C2F6</accession>
    <name>A0ABR3C2F6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616162.1">
        <property type="nucleotide sequence ID" value="XM_066755876.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988177"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0253941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="258" mass="26758" checksum="54C9EE51D0EA5C31" modified="2025-10-08" version="1">MPTEVTPNSHQLAVNAAFYHGWSSMPPSGPARASDLLPIRHIPGSVMPNGLRNPWAHYQGESYTPSAHVAAVQGEQRFAGSDSYIGGGNMVGGRAVSLAGDGGGSVIAPPSVGLDGYREDDGWNGSMGRVHAGHAPDMSSAAGAISQVRPVGCTGGWLNQPATWSNHARMTPTVAAGLAGSEVAPPFYGLLPSYSSIGGHHRSSSVPLNSRRRNSIVGDCPQCHSHGHRRLSSTPVPIDAAEEAEISVKVIISSSEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3V6</accession>
    <name>A0ABR3C3V6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100111</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616591.1">
        <property type="nucleotide sequence ID" value="XM_066754690.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986969"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="235" mass="26595" checksum="21F5C779644831AE" modified="2025-10-08" version="1">MRHLTLIRPALQPIVPRTFARTLITTPPRLLATPSGHTGPQHITPGPPKSPNPLQTGTQDAISAQKYPDYSTGPSAIDKASQLLFLTEIVRGMWVVFEQFFRPPYTIMYPFEKGPLSARFRGEHALRRYPNGEERCIACKLCEAICPAQAITIESEAREDGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVETQNQEFSTETREELLYNKEKLLLNGDRAEAEIAANLQSEHYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3W4</accession>
    <name>A0ABR3C3W4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100104</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616584.1">
        <property type="nucleotide sequence ID" value="XM_066754683.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986962"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23810">
        <property type="entry name" value="UBCc_BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="641"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="880"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="889"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="908" mass="101077" checksum="0F5DD995AB24A446" modified="2025-10-08" version="1">MGDRALSELIDMGIPLGRAVAALKRSKGDAMSAAERVFAGEFDDIPSDDDEEDGAEGSSSVQDKADSAMIHYNEDSAMDEDEMGHEDDENDEDDEDDMNDDNFDYDEDMSDDEQMASDPYAGIFFSKDRVEDIIEPIETEETTTISIPGINTTEVKILGRGEWMSGCPESGEQSFLFQLYNTLEEGRMPCSAGCGHSFTRKREDFFCLFPKFPQYTTYLNRIIRLHCPQCHQITCLACGERVDRPSALHSQHTKDKAPMVSAPDIPSPTTQEALLHCPNLQGVILGVGLHMIERTFSQSGDPTSSIENSGKTPPPKKRKTNGSPPLATGKGAVKGTGYAGNMQEDRTGQIAAEKAQKKADQQVATILQQVQQFLPNPHRAGGPATSDYLVHPTALAHLRRRSAFMNDLLRNDSLFDMSQRGDIYRALFDWLEIVSNNESLASMLAMPQMRQAKSVLSPTVPSSLIITYEGAPPPRELLENVVLQAKAALKGLEGVPLAQIEGLELTEEELRTNIKELEKKEAERVERESLDENSVLKAFCLRIIKSAETIDKRLVETKGKAFVQRMKEQLPRIDESGIQIEKIPAEGQTDEEIIKMYEEWATRARFRYVDLRTGSNIMDAASYKHAYSALITDIELDNAPKRSLAIAKELAILTTSLPVAWHSSVFLRVDEARVDVLKAMIIGPEGTPYENGCLLFDIFLPLEYNQRCPLVKYMTTNGGKWRYNPNLYADGKVCLSLLGTWQGPGWIAGQSTLLQVLISIQSLILCEEPYLNEPGWANMSGSAQSKAYNANIRRMVLADAMANNIKNPPHPFENEIKTHFRLKAKAIRQQIEKWREMDDSKEVEADYWGGAHAHTSVTSALSKRSFEAAAKEILRLLDELEGKVQPGPKAEKGVKIRSPKEGKKKPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C459</accession>
    <name>A0ABR3C459_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="9">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_100222</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="9"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616695.1">
        <property type="nucleotide sequence ID" value="XM_066754794.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987080"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0255418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="485" mass="53353" checksum="9882CC1AF83B1604" modified="2025-10-08" version="1">MISRKGLGFAANILHPKSSEKVVGAHTLHRTFTAQSTQCFPPWPLRSQTTAREMSFSPREGSNHRAGKHLTWELFAPRCQKRSSHSIARQTGDTTVDSSRPFFSAHPIPYSPPFKTVYGAANAPIPKLPDLNLPHPTAPAAPISAYKSLPPLTWKRLLSVYSALSKRNLTILMTLTATTGLALSPLPLSIPLLLNLTVGTLLTSAAANTFNQILESPIDAQTPRTRVRPLVTRRVSPFHAAIFGLVCTVVGGAILWYGCNPTTAALGIGNLILYAAVYTPMKRFSVANTWVGAIVGAITPLMGWTATGASLWPTSDQPLLLHTPWSDLPNLPNPLTPLTLFALLFSWQFPHFNALSHMIRPFYALSGYPMLSVLSPRLNALVSLRHAVLLVPFTAILGPLSGCVDWSFALTSSVPNYFFVRDAWRFYKLTNEANAKKLFFVSLWYLPAVLGLMLVHKNVIGWLDGRKEAEEQEKMKMEVPMKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4E3</accession>
    <name>A0ABR3C4E3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616770.1">
        <property type="nucleotide sequence ID" value="XM_066754869.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987155"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="842"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="725"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1110" mass="120175" checksum="BA0D0943213ECD4F" modified="2025-10-08" version="1">MGPSVPPPQLHHTNSAHPLSTSARHVAHRPHAATISTSRPADALLDTPRSHRPSLNGKPSTIAKPWDHLESLSKRELSIVDTRFDLMSDDELHEYLQNVPCAPEDPTPHVELSSPVFPANGRTSSSAGSSSTTELTPSRDTGDKSPLFPPSPPLLQNNAQITDHPLRVLSRAVRELREVIERLEEENSRLRMNHIEREPSSGKATDQISIHDDLNEAISTSLTSSSSLREVPSRTSALSIPQSELPSVSPTTSRFPAGFSPSSSSSLPFTSASVDPHQPDVDAASINENNDRRSSRQSWASGLWVWGNKKSSVTKKSSMGSIASANQPVTPSSNAIPRSTPEDEDEDETWRKGDGGSSPSYRAIFLATRILTPDPSSILIPTETPPKALIARLAHSLISNARDEGIVAKEPANHRRSRDVSRSRAISLGDQERLQTDEARNKDGKGYGDSALTATASLGRTLLSSVTGATIRGSRSGTSVAGEEARPSLLSRGSSGHGFSVAAAPSSPAISHSAAAVGSPAFEGTPLPSVELSSIVPDESRPPTVLLSRENLGSFFQSNRVNRAKMVTASRFESDEPPLTDRYGFIYDIQHAKMLKDASVAGTPAPMSLNGTLFKNDDPEEEGWIAKHRRGSHGSQKSDSKSIRNTADVKENSPLASPRPSIDSTSLNTQPPSQSSDTPRNVASPATRSRSSSHADQHRHRSSTILSLNPSPARPVTGKDHLTVSARGSSSLHSGVSPSITSTTVPQSISASLSKPISPIEASTNVSRVTISSLLDQLTDLHDRQQKERVAEWDVFIKKRAKSRAADKGRGWTAGLIGVSQMGLSGKGQEDWKTFSRLARRGIPLKYRGDIWAECSGAKDLMVPGEYAEILTVHKDDVSPVMADIDKDVSRTFPGNVFFGGDGPGVEKLKRVLVAYSWYNPGVGYCQGMNMVAATLLLTHSDEEQAFWILICIIDRLLPPNYFSPSLVGSRADQLVLSQIVAQILPKLHAHFLALGVDLASITFGWFLSLFTDCLPVETLFRVWDLFFVEGHDSIFRVAIAILKINEAEICNCKTVGDIFSFISTMTSRLWAADKLISLQHNFKPIIRHTDIAARCEKASELLEKEAEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4Z2</accession>
    <name>A0ABR3C4Z2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616954.1">
        <property type="nucleotide sequence ID" value="XM_066755053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987342"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="341"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="515"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="210"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="730"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="767"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1015" mass="110770" checksum="935B9F6B369AF937" modified="2025-10-08" version="1">MSYQWNHNYDTSTSHQEQEPVYQDNDKQNFGFAPMQGQGMLDLMGIPQQMFFPGVQAEFNNGRTAASVTGGYQSSMPPPPQYQYRPALALDTTGGYLGPQPQTSSSYSELPPGLRTDLGSNTDSDLVTPNSYPSAGVQYTPYSNDFMTPLSVSAGMVNPGQSGGSIEQPQPMLGTYHSTIMPQYGFYPIPHPEMQQTQQPVEQSVQLGTISPSELGQRQPLKPTKSFSDLMMGSRASSSSSLASQDVPDGWNGNALEDWTRPLSRALPSSGTSVSTSTSSRPLPAAADISFLPDHTKRPSFASSPLRNPSFSPLSPSATDGDSIIKQYIRAPNRLAFGERKIIVMSPKVGQKSYGTEKRFLVPHPQAILIGSGWWAKSPDGCPLSPLQPPRINISLTGEQAVKDSIISWTDLNGKNMDEKASTQGIKIDDQPFTGSVAGKNLHISDNDPKRKEVKALVTVKAPLNKHAGPNGWGSAKGTLSDVTNDDVFGVFESKDIKIISKPSKKRSTAKSGELTISHGTTVALFNRIKSQTTSTRYLSVVPDFTRTLGSDGRPVTGAKAPQYASDKGALRGFTADASFWESFIIWLVDPSLPPGPSNHQAPNPDWPRPPSNIIPLNTISHSIRYNSTIVLQSLRTGVISPTLVVRRIETDSDAVGMDGHVHEVPAMPPGELASDLVSQLQKVAFEIYSPDTMNRLQRESKYGGSWLSCYQDEVREHAIKAERKWAVLQAPPGSKPGSRPNSLPNTPQQRFGVLPMTPHTNNMNLPSTPSSPVSSSSSLDYFNYQSQRSSGHNHPLLSPGSVETGLPSTDGGPIRRQRTSSMGKGPLSRPLHRKRLSTDSTGSNSYEYMPSLSSAMSSAEQPMQPQRMFWTMDVGDSCVWSIISVEQASYTFFTPPISNFEQFEPVAPFPVANRLLPANLSSEVPSKYAHQYTSTVNMPLVTIYGKHFAKNVDGRAKHVMYYGDEPARHNEVRCAEVMVASEPEPSTKSDRKKPIFLVREDGKVIIPTPLHYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4Z5</accession>
    <name>A0ABR3C4Z5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616972.1">
        <property type="nucleotide sequence ID" value="XM_066755071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987360"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="30"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="317" mass="35966" checksum="395B63066490020D" modified="2025-10-08" version="1">MSMLRTVKPKNARVKRALEKREPQIVENEKTAIFVRGQNSSDKVRNVMKDLYSLKRPHAINFSRKNDIHPFDDASSLEFFAGKNDASLFVTGLHSKKRPHNLVFSRMFDGRVLDQIELGVEEFKAMSEFPTLKSSLGVKPMMVFHSDLFDTHPTYQQLKSQLLDFYNGHPITEAPLLTTLEHVISITAGPVSDTTPLPRVHFRVYTVKLIPSGTRVPRLQLTEMGPSIDFVVRRLQAPDEEMMKAALKRPKMAKSDVEKGLGKKRKNIETDEMGDKVGRIHLGKQDLSKMQGRKMKGLKVKDGKKRKTSGAEVIDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5A1</accession>
    <name>A0ABR3C5A1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_100616</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617084.1">
        <property type="nucleotide sequence ID" value="XM_066755183.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987474"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 13" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="14">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0255807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="104" mass="11732" checksum="5768792A46A3E2C8" modified="2025-10-08" version="1">MRSFAVGPPEPLALTKDEISDMLLRVLNQFKQIDSSKLIGNASFTSDLGFDSLDHSELIMSIEETFDIDIADNDICELDSMDRTVDFVAKSLETRRFVEKVKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5B0</accession>
    <name>A0ABR3C5B0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GSKIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617079.1">
        <property type="nucleotide sequence ID" value="XM_066755178.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987469"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSKIP" evidence="1">
        <location>
            <begin position="79"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="145" mass="16302" checksum="5434F75D5C97DE97" modified="2025-10-08" version="1">MAFTSDCILLDPLPEINAALSSSSFGILPAPDSQPLLEQTFPRTAEELKSVREESDRSHEISERVVGMCRVGLLDGEGHVLVRLDRAGWTIETADGERHVTNKIGTTYESMESLLISASKKYVEAMNKEIWKRFENHPQVTEERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5H3</accession>
    <name>A0ABR3C5H3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U3 small nucleolar RNA-associated protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616697.1">
        <property type="nucleotide sequence ID" value="XM_066754796.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987082"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="35191" checksum="7B7A83C86C3D8926" modified="2025-10-08" version="1">MVNAARKNLMSRRNHKERAQPLHRARLGHLEKHKDYVHRARDYKSKQERIRKLREKAAFRNKDEFYWGMVKGKTKGGVAIGERGFEALSTEVVKLLKSQDLGYIRVQIAKDEKAITKLRAELEVTSPASHTSEEWSAASELAEVEKLAEMGVVLSPALSSKKGKGKSKAPADVENYGNESEEEEQQKLEEEQVDLGWEEPRPVKKRKAKTVEPMKDEFNEEAAAEEAREYRLQLLSDLSAHLNRLKLLRQAEAKLETTKGLMGKGAVKKVREHGWVEDESQPEDRNGDRKKWQGKIWKWKMERRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5J5</accession>
    <name>A0ABR3C5J5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_100704</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617170.1">
        <property type="nucleotide sequence ID" value="XM_066755269.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987562"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0255893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="480" mass="52932" checksum="71968D63913D9988" modified="2025-10-08" version="1">MLLATALLLPLALALSPPPQTYVNTAIARTVELGGATAQVTTQYNIKATADEPGEYHLALSGDGDDIPAWWEVAIGGKAVEGVRILDDRPPTVSVPLGHLKNGDTATLSLTYVLTHMSRPLPAEIDQREAQYLLFTTNSTYVDSWYPTSVERVKYRAPHIILSHTSVPDTYTRDSTVTKTGSSLTLGPFHSLPPTLGERKFEQQPLSVHYENKQPVVGLKTLRRNAEVSHWGANLNIQDEMSLVNIGPKLKGHFSRLAHQQSRFHASTPPQIFTELSLRIPATAHSAYYYDTIGNVSTSHFRPGSTLAQKSKTSKVRTSPRSVDGLLELRPRYPLLGGWNYSFVVGYDMPLEDVLKSDQANGKNVLAVPFMTGINDVVVDDAELKIILPEGAKDVEVYTPFAVDSIEHSIHKTYLDTTGRHTIILKKARCTEDHAKTVYVVYSYPFSALMQKPVTVASVIGGLFLLAMGLRRVNYSIDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5L6</accession>
    <name>A0ABR3C5L6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_100733</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617199.1">
        <property type="nucleotide sequence ID" value="XM_066755298.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987591"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="15">
        <location>
            <begin position="111"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="219"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="288"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0255922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="420" mass="45775" checksum="33D03220DED31BA6" modified="2025-10-08" version="1">MPIAIPTSQPSSAAAPNTPAPVVPPAPRNPVRLSVAARDHYPPSAGPSTVSSTRVQADSIPSVDASIAPAGGEDAEALKRAAIRKAQLQRRVERWMDKLMEETVDRATFKKSVSHFTPLNYLEITHERHLNSLCSYPVCPNPPFRPYSSSRRFIISTRARTIKPKEGNEEEGYCSKKCKARSGWVEGKLDREAVWLRGKVEDIELLEELEERGEIDLEAMMKEEPRMANRRESTARTTPSPVSKPALPPTQIISNPKQPFASESPAPAPSANAVTSLIESLTIHERPVPSVAPAPASPSGPADHSTSSQVPPAVEPQPQPLPLPQPQPQSSLSTHARRNPNSLLSTSSTLTRSLLSATNSIPAAAISQSSRHGDDSEEEESEVSEWEREMSFGEETEEVKGWFEEAMAAREMLGDKEGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5V8</accession>
    <name>A0ABR3C5V8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_100814</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617280.1">
        <property type="nucleotide sequence ID" value="XM_066755379.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987672"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0256003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="117" mass="13011" checksum="E6BA53BF72FC7C9F" modified="2025-10-08" version="1">MPSATDQTLENQNEEELNSLHSKIKSLRSVTIDILDDANRQNDQLDRTTNTFSSFASSLFSTSRHHSRSIAANSALRQYRMIAYIVMGVVVLWLVLKVWRSGAGPTAPAATPLEGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C609</accession>
    <name>A0ABR3C609_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616877.1">
        <property type="nucleotide sequence ID" value="XM_066754976.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987263"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="6">
        <location>
            <begin position="145"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="721" mass="79364" checksum="9E7568D32FC399F9" modified="2025-10-08" version="1">MPKATRKKKEKQADFVKAKLKLGKGKKQASNTTDTSFKARSIALPGQEALNRALQISEGTGPSEPTTGSGLTLEDIFIRLRHPNSVVRKEALGGLKEILQVDVSREVGKVLRALGGLVADDDAAVRKSFLALLDWYLAHLSQSILSPHLPLLVLQASSALSHIFPEIRLDACKLVYLMLQYVPSHVVSSWPYESSNILEGLRLAVGLGGEKGINSQIGRLTGGAKLVTMKAMREFVRIGLENGMTQKWGERYLEGRKGSKGKFEVMKEESGMGNTQLEGWLVGARMARLVDGGDAWELGRLGSLGGKGDEEGVVNVLAQLYIQLHPLLLSTFLENAPTAFSPSTATFTPASEDIPLALCVMTASLTELLADAILTRATPDANTPELRQVKSCISDFHRRMTGWFPFNSGTTPTPSGVTPGFELSLAYARLAVLLAPQPVELTFIKHSTKRGKEVGWRERVKATEEAWKTMREAERAKGKGKTGQNQWAMEEVADWVVEVLTPKKDVLAPSLNPEAYSALLPIVWALLTQPPSCPPSDGSDIPSHVGSAFMSHLLRQGSSSPIREIGEEFLITLILVHEKKYPILPFYIVPQSPLRPMIKSWFEGIPKTLFELGTKNERASERLLRFLLEIGSRGEGAFEQPYSLIDPTTFPDLTPKLAPFWHLQHPSKGSVPGAWTKLSSGEIKRLGLDVAMIWKQWNGIRLRDAIGRVCGHDQWGFHCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C622</accession>
    <name>A0ABR3C622_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'/3'-nucleotidase SurE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616508.1">
        <property type="nucleotide sequence ID" value="XM_066754607.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986885"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="2">
        <location>
            <begin position="95"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="387" mass="41131" checksum="8A15301EC6F5EE74" modified="2025-10-08" version="1">MPPLQTYGERPVVLLTVRASAPAGLTFAERRRPALRRLAEHLFVCESAGEPARVGCAGGDPGLAKVMGGQGICDQRQPDGRTGEVTHVPRPLKHGESMEWVLLSGTPSSCANIALHNLYPGEIDLVISGPNHGRNSSTAFALSSGTVGATLAATLSVPLPGPPAPAPALHTEHVPCIALSYAVVSRPIAPRLLALAAETSVDVCKKLFDNWAHDPAPGRAGKVQIYSVNVPLVEHYLERGNRKAVYTELWKNAYGSLFKPTTRDHSHFDPGDDPDQGNATTGHQPNKPQAAPVPSHTKTSDGTPGPAALPTPSLTPAPTPTTAQTPRQRQLKFRFDPDLQPVLFPSEDTLTEGTDAWALAKGYVSVTPLRAEYSCVPVAQFGSELHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI41</accession>
    <name>A0ABR3BI41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610868.1">
        <property type="nucleotide sequence ID" value="XM_066761043.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993475"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="109"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="373" mass="40942" checksum="2CD593401B0BB8D4" modified="2025-10-08" version="1">MGISWLLKPVALVSTVALSTLGLLSRRYQRARFYFNITIYVSTLGLMSVWGVVVSILATAAGQRLNINYYVARSFYGLGSPLLGIKFEVEGEEHLEGLMTARDGQHQGAVLLSNHQSFLDILYIGRIFPKRAAIMAKKELKWAPLLGQFMSLSGAVFVNRKNRHDAVKALAIAGEDMKKKGISLWIFPEGTRSSSPEPTLLPFKKGAFHLAVQAQIPIVPIVCENYHRLFDGRTRFESGVLKIRVLPPIPTTGLTVDDVTTVAESTRESMLHALREISEPGPSSSLSTSSATHLAPPIPEHITQPPAGAPIQLDISDSIALRQRGANFSSISSGVSSEWSESERKFEEKSEETTEDEMDEDAVLLKKPKESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIG2</accession>
    <name>A0ABR3BIG2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chaperone DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_106626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610874.1">
        <property type="nucleotide sequence ID" value="XM_066761049.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993481"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046814760" evidence="6">
        <location>
            <begin position="21"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="137"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="137"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0240375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="370" mass="40776" checksum="B4FEAE397656224B" modified="2025-10-08" version="1">MLPTTLFFLLTLALLGGCLAESLYSVLGVRKDASDADIKKAYRKLSKKYHPDINPDEAAHEKFIQVSKAYEVLSDSETRTIYDRHGEQGLKQHEAQKSGGSQDPFARFFGGGGAAQEQKGPGMITNVEVSLADLYTGRTLEFQIPRRVICSHCHGSGAESEKDIHTCNKCGGQGVVVQRHQVFPGMFTNVQMTCPHCNGKGKQITRSCHVCHSEKTVQTQHTLALHIPAGAPEGFEEIFHGEADEQIDMEAGDVVVRVRSKMNEGEGAWRRKENGILGRVTLSVAEALLGFERRLTHLDGRTITLSRTGTTQPGEVEVIEGEGMPSYMDIPPGDMFIEYSVVFPTSVSSETRQKLSEILKYAPPVYHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIL1</accession>
    <name>A0ABR3BIL1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial splicing suppressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611031.1">
        <property type="nucleotide sequence ID" value="XM_066760759.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993181"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="1">
        <location>
            <begin position="92"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="2">
        <location>
            <begin position="203"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="60890" checksum="EF225AB7964DC387" modified="2025-10-08" version="1">MRTITAASLRRTRIASSRLVPSLPIAPICRPIALPHSHTQVRPFFSIFKKKTPAPAASQAPLLSQDDLFHHLSESPFPALREKADRIKSVSLCPTSFEKHHERVRPAYDCPDCGWPTHKNRERWEEGREEHKEYCGRLREVNEDEHDLRSGRPMVEFENMPEEQPYESAVNFASWDTLFFTRGFPSIDSDRSVRHVSKILTYPMTIAGILHQNGPFTSANGRITRQGRRSMAALHSVLHLPPGSTVETAVDEKPQPPFRLFLLGARAESTLPPHLWAQLCYLFPRTTFQIYFIGPEVGLPLLNATERAKPTYSFSQDGGWGVPSYNLNYNTRLSLTSVQASYEQIHEQLGPFDPYTDVFFAFSPGFGFPHQPLLEKITKGGKGQVLLDGSEEPLKAEEHNDTPAGIESDVPYAPPETLVQAQTTWCRPLQLILETKCPFFFTAFSPLDLQRDVSALFGTNPPSASSPGSPVREFPDYVSLPTGPIEPIEGVTDEFELVLTPGVNPFGSLKWEIAEWDVRVGVKTNWGTWGIRGKKYDVVEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIT5</accession>
    <name>A0ABR3BIT5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610994.1">
        <property type="nucleotide sequence ID" value="XM_066760722.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993144"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33236" checksum="9396766527FBFBEE" modified="2025-10-08" version="1">MDSLPVELIQQIHLLALNPFFPLTSRTIYASLHRSSPFYTAQYLLRLYRTHGPNEVLVRALRHPVCDIHVIQALLEAWDRSRSRRTDSHNDQNRPRQIPIVPPLTCRELPRRLFRSLPLPSTPISPLVIYIFDTFGQSSDPAYDPSPNSHKGYPLCRAVLQSNYELASYLLQKGADPSLKDYMAVEIAVSMKDLKMVKLLVEREQNGSGITRTENKSESPAKKIKLGDRITVPAKMVESAMKKGAKDIVNYLVYDKKVIPPLSSIMDLGKADAKPKAKTKHQFTKPKKRKAGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ29</accession>
    <name>A0ABR3BJ29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_106564</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610813.1">
        <property type="nucleotide sequence ID" value="XM_066760988.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993419"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="362"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="553"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="629"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="699"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="306"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0240314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="743" mass="83463" checksum="16F14D6E82D6A7C2" modified="2025-10-08" version="1">MPPSAHPQTRPKPLLNVDSDPASWLNFSLPPRVRSGAGVPGSGVPGPPRRSRKGGEGWRGGVLNREKYLNASFKFVLKPNEALSYGAHFADPDISLHWPNILQILVPTFSALSVAQGYVSESHAEDGYKSHDLEEMGEEAAERRRRMEEEKRGRMCPICLGKPVAGRMTKCGHIFCFPCILHYIQLSDIPKSAKCPICGDMVQSSTLKSVKYLDAEAMLEASPHSANDAFEASLEEAKKLDSGDRHDKGHRLHMRLVQRPQMTTLALPSSSTWPSDAVPPHTAPWYFLPDIITYSRYMLATPEYMDKELEREMTELRREWELLRGDELGRVFVKAAIDKVERQMNKVKEELETDFVRRSERKGREAWGSAVGGDKEKKQQQRERERKEQERIEREKQPGIGPAPVESLANQQTTFDNSANINIPPNLPVEPNPMPPLLRDKKSRRRLSAAPPPQSVPPTPSYYFYQSSLGANVFLHPLDIRMLLAHFGSYNLFPSNMTFETTGYDPGTINDDLRKRCKYLSHLPLGSEVVFVETNLADLVSSTILAQFEQPLKARRQKRRDKMRKEDRAKQKWERAERSKTAEELQSVRSVPSAFVRGGVEEDRELELALARSAVEFEQNFPMAYPQPGMASSPPRSNAWGQPPIQTQSEGQQVQPRSFATALHQRYDPSLSRSRREVDPEVDALWQQFESMDVHLEPGMTADVGAGTGTGAGADVRESERGGGKKKKEKGKKLILGGGGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJI5</accession>
    <name>A0ABR3BJI5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611337.1">
        <property type="nucleotide sequence ID" value="XM_066760576.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992984"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0241955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="307" mass="33308" checksum="1F24660AF480E273" modified="2025-10-08" version="1">MSITPVSPSRPVDNSVQHPVQSIELSFSSGPGGAWDDRELINAANSAMKEFHIHHPGPGSWLDKATAAMALGRPLPGANDYGSAWYTASTPAAPVEETSSAAPPKKKRKTVKKPNAVNPYDPVNTTYNSAGNGAGPSGTAIINRNGRASPVYQPPSPGGLNAVEQAQVEADEQAAEDAEWGDVEENWDEEDEEDEEEGDWETEDYTYPRQAGPVQPQPAPPAPAYGVYPAAGISRDEALGHAMTAQYWAGYWMGIAQTKEAEEKKCRRKTPRPDKAVVEEEQEQQQPSNLIVTKHQYSFNMLNGLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJN4</accession>
    <name>A0ABR3BJN4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610975.1">
        <property type="nucleotide sequence ID" value="XM_066760703.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993125"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="3">
        <location>
            <begin position="452"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="700" mass="79585" checksum="B9E253F18338DE42" modified="2025-10-08" version="1">MLCDTDKGRDLRQKSTSPLPIPYWSHRKLTVDPSNKERIDRSARMTARQAALLEWDINLSDPEQGHIALAVEQVRKYIYPRNLYQVGSARPQISPEVSLAFAIVKQYDMSKSIFDDFLDDIENNFELIEYDVLSAIERLETPAEGDNDKLVLRTMSGLFERLATWQRSWGLPLRAFQDNIYVALFTRKFHHLLHSSFPPSFPDHLLHFLHASLASLPEYLTNPPPQQGYLHSVPINYQKVLPPTSHLSRLGVFPRYAGSLSKVAHEEIERIAREEAGKGWGERRLGRARQRIGDGVANWLSGMFEGNEAVQGALRPMFSRFDYFLCKCFFDIRTDELFDIIIDFPDSMAALEDLKECLFKVDQRLELVNKLNAANLKRLLHPGAETHVILNIYISTVRSLRILDPLGVLLHAVALPIREHLRKRPDTIKCIVEALVQGEELQDENEGGLIGEGDSEAEDFSDPRWEPEPADAAPEFRSGKTSDIVSTLVSIFGTKEVIVKELQNYLAGRLLQVKDYDVVHEVRTIELLKLRFGESALAGCDVMVKDVADSRRIDGHVQEEKKSVVHPLVLSKVFWPNMPRSSLKLPSKLRKMHTEYESSFHIFKPDKHLRFVPHLGTLSLSISLSDRTVTVDATPLQASIMELFENQDVWAVDQLMDKLGVGKGEVVKALGWWAERGVVKDEGAKGWRLLEIAEEEFEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJW1</accession>
    <name>A0ABR3BJW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">B2-aldehyde-forming enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611467.1">
        <property type="nucleotide sequence ID" value="XM_066760163.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992568"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046853650" description="B2-aldehyde-forming enzyme" evidence="3">
        <location>
            <begin position="18"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0242085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="37365" checksum="CDE69452480A02EC" modified="2025-10-08" version="1">MLALFALFQLLPILALAAHSPPQRRAHERARKNYEQTHGRNAEDTPSIVERDNHYDNRTIVERDHFDNRTLTPRGTTYTGVGTFYYTGLGACGLNSQDSDFMVALNSAQYGSGYPGPQCFKYITIQMGSTTIGGVEILDECPTCDYGSLDLSPGLFTHFADYDAGTIHITWWFDDDSPASTSTSETPTSTYVPPTSTWVAPSSSSTSTYVWVPPSSSSTSEWVAPSTSPTPSSTSQWYSPPAETSTSTTPTSTWVAPSSTSTSSWVESSTSSAPNSTITSSYSSASAAVNSTNPYAIISNASNSSVSATISSNTGVSDGSSEASVEVVGNLEMIGALAAQYGQLVVEAALQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKE7</accession>
    <name>A0ABR3BKE7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611275.1">
        <property type="nucleotide sequence ID" value="XM_066760514.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992922"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="301"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0241893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="364" mass="40234" checksum="6B3640DC702C499E" modified="2025-10-08" version="1">MGFFKRRNEPLIPPVAPTAGQPQPQQPQADPYATPDASTYAGAGGDPYAKSKPRPSDQSGEKGRSDPYAATPTYAAGGGGDPYAKRNPGPRPNPNAANDAARAELFGGFKAEDVPAERKYGYEGREMEEDFDEDEEIEGIKQEMRGVKQDSLASTRNAVALARQAEESARGTIAKLADQSERIANSERYLDMAKANNQRAEDKTTELKALNRSIFRPAIVWNKDAKRQAQEDKINERHAMERMDRAKALLDVQDTRKRLGAAANPAPYGSSSTTPEPVPGQQKARKDARSRYQFDATASDDELEDELDENLDETLEISRRLKTLATAMGDEVSGQNSRLTRVTDKTENLEFAVMKNTERLKRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKE9</accession>
    <name>A0ABR3BKE9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611652.1">
        <property type="nucleotide sequence ID" value="XM_066760348.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992754"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="788" mass="86032" checksum="9CC2E075FA1E0F9F" modified="2025-10-08" version="1">MAISFEGYPFPVYSIDVKYCLDIEKGKANIKDTKSASLSLGEHLSPPVFLNLPCLALLSLSSRLTLRTNIMSVPRTPASVPRYPSSLSQSPSGPSRPPRTYPIPSIDSSVASPPLPPAPLNEYTSLQDLLQRAGYKETRVYTPEAEKVRKHIKKTLDDNEEEVDALYGTYGFDRREGPGIHHAHQNVTEPIMPMKRSASILRSLALQAAARSKAAVKEGVPDNSWWATWGKTQKISSPEAPTKVGLGLARNGEGVRKVQSAWDVEKGRCRRAETDSPPQEERPPLPQMRKTSTPHEMTAATGYITKETPTRPIDRDIFSSPPPPQALSDDAYGYCPLPDDYEAQCEEDEALYAMGVNDYDVYSIGSYSASESAHSTHSRTPSDDRAEREIKDFEDEGDDGLLDEVNDVGKRLLANAVEYDEDLEYDSPPLRTWVLPQVDTPRPHGAPKIPLPSPPTEIIPHEEKMNSVQEPAKPLKYGDRATKLRLAHSTPNLKKADVQSPPLPAGWLGSIRNALLGSTQSLSPTPATSSWNPSIPIKVTAPTPARPRLVTAGPVICDSASGEAEDLPPIPTPKAEQSSGPISLLRLRPSLAKLRDAVLGQQVEADKDDPLVLSPRMDWKQQGEQFAGWSPMRKKGDGSEGESLYNVRDEGIDFSKSFFYKPGTPPKAKAPRGCETPKANNTNPSRGLRKQRSIKSLQAALLLPVASSPIPPVPPIPSHLSTPKKRIPALAIQSPQAAQPRELILDGDEFNPQSVPGSDKRGRAKAKKGNGVRRRKSKKKNVLKGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKJ3</accession>
    <name>A0ABR3BKJ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="8">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="7">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105937</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611690.1">
        <property type="nucleotide sequence ID" value="XM_066760386.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992792"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="67"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0242308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="546" mass="59761" checksum="1A5DDA74F801B395" modified="2025-10-08" version="1">MTSQLATFKVPVIDNEPMRNYPPNSAERAGLQAAVNKMLAAGPVEIPCIINGEEVKTGDIQAQPMPHDHAKNLCTYHAATPKVVQKAIDGALGARQAWEEMPWADKAAVFLKAADLISGKYRYELMAATMLGQGKNAWQAEIDAAAELCDFLRFSVKYVEELYQQQPPRNSTGVWNRVEYRPLEGFVLAVTPFNFTAIGGNLVGAPVIVGNVCIWKPSPMATYSNYIVHKVFLEAGLPPSVIQFVPGNPPEVVKQCIDHKEFAGLHFTGSTHVFRKLWKDIAQNLDIYRGYPRIVGETGGKNFHLYHPSADIKSGVVQAIRAAFEYSGQKCSALSRCYVPSSLWNNGFKDTLIAETEKIKTGPCTAWENFAGPVIGKPAFDKITGIIEQAKKEGGEVIAGGSYDDSKGYFIKPTVIVTKDPKSLTMTTEIFGPVLTVYVYEDAEFDNMPALIDSTTEYALTGSVFARERSVIASASHKLRNSAGNFYINDKSTGAVVGQQPFGGARASGTNDKSGSMAIFSRFVSMRSIKENFVAPEDYLYPSNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKP5</accession>
    <name>A0ABR3BKP5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spc7 kinetochore protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611380.1">
        <property type="nucleotide sequence ID" value="XM_066760619.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993027"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="3">
        <location>
            <begin position="592"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="810"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0241998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1090" mass="119976" checksum="AA386EFE79575A3C" modified="2025-10-08" version="1">MSLATRSPRSRKSLSAVDTNININDNFTLPVTNKGKRRVVASMGGEGIKDMDAASLKADNFSLKSNPRRNVEPRKSILKSFSAPYIARQAEDETLDYTNSHQYAHTVAFGPLSNGDSDPASRNSRQSLGGRRVSFAPNAHVRMFERQVTKNPRASVGLSFTETSTPSLKSNHSRRSSILNIGSVSKPNIFASGIFQGEGEAQGEESMEIEDDKELSGIDVSERDEAQQEYSHDGGTEGEESMEMEEEDMDITQQIYGGIVRRSSIAPSVAEPSELDAGADTEDESDSGQEHSHVEDEEKTMDFTIAVGGLLPHEAPATATRNRNSIGYSFPNPDGPALPNLMPGQPDDHEIEYSMDETEAYGAIIGQDFSFSSGSEDTMGSRNGDKTMTFTYNHHTALPSQINGGDGMDMTISVGGIVSLPPVSPRPVVSDQTRPINGTPSFARPTVSSAQKSTASKRNVFAPSPSPLKSATPRKSGIQTAAEVAKRLSFGSATSSGGKKRVREDSQEAEESVKKSRIEAAAEEVFGIPHHASPVTKQNAEPPALVVQNTTPPSDPPQGTVTSARRSSLGTALRLSLPPRQEAEEQYEENAIELQRHMHEQLQDVSLAAFLEIAGVQFMEGLPGLNRKRSSVAKEILGHSYANERDFALHEYTEAQVNSIFLNMYTWASNKLFQDIQTGDEELAAVSARCDIDSPPVIQEYLAASDEDKQLFEMTFKSFKTNTHLKAKEMWYDWMLQLLETIKPDVETVLMGMKEDKKRLTAFEEQAAVLLPQLRARKTEVETKLVKERKAVAEIESCDQAELAAYKEAIAEQSAQITNFSTEVADLKDELAALTGKLEELNAKKHEYETAIAHAKGQCDQFTRSDAIRLQEESISLQHLHLWRPNKILPGRMELSYDAEILLSINCANYVPDISSASLEYLPERMQSSKRKCLGIRGESPTKCLFEVFKGAVGDVIKYRTWDLPSFVQQTGLLWSNAQRIRAELRYIEFHHPLFIRYNPSTFLMSASVSIMVPQVKSKVLVWFDVDKSVIGGFPGSLGGVGVSVKRVYGQADANLLEQTARQTIEVSRPEACLGTFLQVCVEVGARYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL48</accession>
    <name>A0ABR3BL48_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611864.1">
        <property type="nucleotide sequence ID" value="XM_066759918.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992318"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04043">
        <property type="entry name" value="C2_Munc13_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="611"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="795"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="4">
        <location>
            <begin position="1025"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1226" mass="139193" checksum="4C27B119B7328894" modified="2025-10-08" version="1">MSTSNDELLEYILRVAYIHGELEQQQLRGRAAQADSSSFPFPPSSSSRRTPESSSSSSFFAFDFGSLVNRDTSKSPKFPEKLLKTIDVTLQRIAMGQQAKYSSPSFRRSVALFWSSTWPEKSFQRQLKESRKIEDLILAFVTAATKSLKKEDALADSWKMELSRQVSLFFDLLSDCISAMGPVSSELKARLESYQGYLKVQDTSNVEDKSLGSSLKSSNSLRSLAPKEEEIPGKKSVDLIEVVTQLFGMPTEVCRQKVEDLKEACTRQAALDDLKICLKRLNTEDPYPYKPQDFDDDTTSWASWKADELSSLSQTMLQMMQLDPTLVQSSSRLSQSNSLQASSSDSVTYPFTFIPSNPRQRYYQLLGKCLDHDLEVLKTLPEDQDVPLSILSGGHALLLSECAGRWRLPSFFRSRVFLEAIVRRFSEGLVPSACVQEALSMMDKVQTDQPLSTWPVSEVGHESVIAQRDESFLIAIRHAIDGPEGYFSEEFLEAAEDWSVLNTRFTNSQNIRHLRRDLEDAIQSAAFTLYVNEATNGLDLQESKSITFLMHMVTWIEKGVKTLRRRFKGPIGQDIPITKLVLQRQLDLWLRDLEDVLQANEFNGEFLDDQFELYNKARMLGEMCDFFSGNKKDSYGITIASMFDQVVRQWIDHTATKTAEWSSQALAVDNFEPSSPHGPSSSVTDLFASLTSAAQFLMDLEWPDEPQLAVYVNKLAKLEELFLSDMRQSETSQTMAKKKAWLEKAKETVATLQGERKLQAFFNFTPESCVKLNNIQAARQQLDKLYNLLRVDDLSAYDTSASQSDNQQRKFLFTVKIVLAEGLAREGSSGHPDAFVTVSDEHGTRYAKTRTVYDDSNPRWDESFDIPVQHRSWFMVTVRHRNMIGKHDLLGRAYLQLDPSQFSGVMTRDSRLTLDPRGHILLKVGMEGEEDDMQFHFGRAFRCLKRTESDMIHTLVDKMNPVLRHTLSRSAIKSVLKGHANYPPAYNEALGKLSAVYKSAMRTQEFFIPPTKEERHRGPTDSEIETAIHPLFDYLDVNNHTLASTLSSDEMELVMAKLWKQILVTIEGLIVPPLSDKRSHMRPLGDMELDIALSWLRFLKDFLYAGGDSSGVSSTILQNQRYHDLLSTRLYYDLSTDKLMEECVRGFQSTLKYRVTKPSKSLRAQRNLGTIRARKDAKQARVVNTSGNTEMIMRILRMRDGTQEFLAQQLQTISMASASKAKRDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLC0</accession>
    <name>A0ABR3BLC0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF985 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611394.1">
        <property type="nucleotide sequence ID" value="XM_066760633.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993041"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387:SF3">
        <property type="entry name" value="DUF985 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="RMLC-LIKE JELLY ROLL FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF985" evidence="1">
        <location>
            <begin position="17"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="243" mass="27259" checksum="1A1C75EB9074252E" modified="2025-10-08" version="1">MPTTPRPNYPYPVPNSELIATHSLQKHFEGGFFVQSVAAESAVPKLPAPQNAHVPQSDALRGRVQHAFGPGTELLCGPSGNELVGEDKRLDATLIYYLLTPESYRGKMHMNLHSTFHLHHSGRALYTLIRPPQKDGDEPTVRHVMMGSNSSLGEVTQLFVPGGWWKASEIPEEDMLLLEAVKDNDLKERIGCLISEVVVPGWNPDQHQFIDEDKLRAMWGTESGWEQYTKYIHPPQGVEYPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLH7</accession>
    <name>A0ABR3BLH7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611984.1">
        <property type="nucleotide sequence ID" value="XM_066760038.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992439"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="381" mass="41470" checksum="AB782F975E419CCC" modified="2025-10-08" version="1">MSTSTLLPMSKVNISAQSSEETSSHGQTKARHSFSSSLEGTRRQRISMACLYCRRRKIRCCGGSPCRNCQRSKRECDYAPVPEEDNRTTREKKAFAKASKIANQLLPPATTSSPYNVSRPTYHEPVYGPSVRSAPYVRKRSSSMPGEAMPMGVPSAYDPPQWIYSQPNYHFAPPNQPSLVSTVPPYSSHFEEPLIQAPMSSQQSAPFDQHQVQPLKVLDTPSPISSSMSSFAALTRAPSSDDEHVPGAWLTPGLSTPLYLPPVSSGSLSPSFVQTAPCPGTLATLHQTSTPPTPTSMTFPSPHVIPTLFFPYAHTQPTNCTTQSVPADKNGQSPMISGSAGMMMKEPLSGLGLAENRDMYLGHGIGEDYYSSPLYHQEQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLN1</accession>
    <name>A0ABR3BLN1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Metallochaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105671</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612068.1">
        <property type="nucleotide sequence ID" value="XM_066760122.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992526"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="429"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="539"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="60"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0243701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="66687" checksum="D6D70E91CF59055B" modified="2025-10-08" version="1">MPHPDLSIPLLPDAEHDLPLPHPHHRPQYTWPEAGPSSPRGTSAAGFLGNVDAEYAYTTRYPQSEIGDGRGRGQEQRKRVDRERGMGVETEAGRDADTERDADTERDTDLSKAGIFGAKAIAAMTGAMATSLLMTPFDVLKTRLQTVPPHLHPSFTPASGPIPPSAPIAINSPSAAAAAAAAADCCQTTYSGAGTSIKPQHPLVCTHSSSISIPFTKPGGGMDVSALRPSPSPPANPDANPNANANALRPPSGCLNPSKWAGIWGEPIPGGGGGGVLVLREGPGVALGGSSNIGVGGLLSSMKSSTSGAVSGGIGIGSSTSTATGGFWKEVAAVRAESGIRGLWKGVGTAITMGIPSSAIYMLGYEQLSTVISPYFLDSSEPVYTTTTTTTTSSLTEPGSFGDSIEFESLSTLPSSSATTTATRTLTASLTPAPLIAGSLARTLSATVISPIEMFRTRLQALPIPGKPSPTYTSVTKDMYRLVQSKGPLILYRGLGPTLWRDVPFSGIYWASFELLKTSLTSPDSPLPFSPLSTTLGLGPIPISFMSGFVSGTFAALLTQPFDVLKTRRQVFNPTPGCVSDRQGGGIGMGMRMGAGTVSLVRHVVKTEGWAALYAGTSARCGKVAPACGLMIACYEGVGRLLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLS5</accession>
    <name>A0ABR3BLS5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612124.1">
        <property type="nucleotide sequence ID" value="XM_066759477.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991873"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="773"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="773"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="667"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="866" mass="93989" checksum="FCCE133A7C409DF9" modified="2025-10-08" version="1">MYVSHLNLNPHGAIGQPSPSIGVIGKQSQAIDSFSPAPAAAHARQLVTSLSQGGRPRTPINRDRDISGNRDVVSMGERREQGNVESDMTNLLAQARLHRTGLFSDREIHSQPHSPSRTESQSRSQSQSPMQPQRQYQSQPQSQEKDDITGGIDDFRKRWERESGEGRKRFDEETWDRNAVRMGMSTVQRQGRGSPAPGGFGIGLGGVGMGSGFGLGGMGAVSGGTQSKTTTGTIPSYQPFMDKISSVSSAQYRPSLSPSNNYLPSSTYGNQAASQSQPYSQPQTPSHTAAPITLVAGAGGQNDTATQITRHLESLTILLNPLVAQADEVERLRKEVEMWKSEWARAERERKKLEEKVGGMGMEFEKAVGKRTDNAGPSFTAVLINGDDLIFQDTYLQAGFKGGQLAAQRLLSSISNLAAGSPLSNASNIGVIAEEVILGLDGLPANRDKERDNSDGGGGAKTEKGGREMGNVVVQIFVNKQGLGEILVKSGLVPSWNVCDQFWQGLSSSQELFTVCDIGQGKEASDAKIREYLRLYASNAQCQSIILGASHDNGYANVLSTLQRESRLSNLFLLGGCTTFAPQLKTYFSRVVSIPELFRLEEVPPLLLSFTSTTADAISAIQAGDSPDLMSSVSSVGGISFSSVVASSPKDKESDIAASYNPTIRDNTTAATPTRNISLTAIKKAGISTPKREEEESEEENEEFEYEWGSGAQFKGRSDLAPGFAQVSGKKKTSAPYSRVGGKDREMDDEWTEMTPKKKTKGKRKEAAEYVRSLKPRPCHTFYLGPRGCKNGDDCQYGHEYKLNGAQLDELSRLAKCIMCPYVKDGRCRYSNDDCVYGHQCPNPGKCVFGETCRFYELPNGHGELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLW1</accession>
    <name>A0ABR3BLW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612119.1">
        <property type="nucleotide sequence ID" value="XM_066759472.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991868"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="171"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="567" mass="60946" checksum="350E7ECEDBFC37D9" modified="2025-10-08" version="1">MPSLKESKNSKPAKKQPVATKAQGTTFASILSAIYYYTLGALFSNISNSVYSLVGSLGMARWARDIVRIVPRKPGVINLRSNLGSGGAKGGKGSKSLTEWIDESVPSLKGRFTPAAWLPNGHLQTLFTAAGNFTKVDKVHYVRTYLRLPDGGTLGIDATPENHGELPADAPTVVVCHGLTGGSHESYVRNILAWVAKPKEDGGLGGRGVVVNFRGCAGVPVTSCQLYSAGTTMDLALALHFIRNRHPSSPLIGIGFSLGASIVSRYLGEYGSSSILSAGVVLGCPWDLTAMSHKLENDWFTARVYSSTLGRNVLRLFFKAYDQNPAVFDEPDSPIREYIEELKEERKNQGMGSRLRRIDDLLVSKIGGPKGIGAWPFPSAKEYYDWASPTHVLSNIKVPLFAINAFDDPVIDGGALPLDEFLASSHIYTAVTGGGGHLGWFDGPFFDKTKSKHRWVLKPVSEFILACTRDLSPPDEDHDSGVDVIAGSRIGPKGADVKLGTEANGHADVKANIDADVEANADGGWEWVVNPKYTIPGLEKVGWKVLREGEVVEGESDEGEGGLVQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLZ2</accession>
    <name>A0ABR3BLZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611845.1">
        <property type="nucleotide sequence ID" value="XM_066759899.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992299"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1138" mass="124332" checksum="610DFDE83B7CE5A7" modified="2025-10-08" version="1">MSTAERSPLSIQPPLNDADLFSDYPYPPGTPTAGIYARDGLWDEPEGIDASFSSGLNWDDRSSSPTIYWSAQTSRKTSLAPTIDNTGKSMGRRGTFFSDNERGPTVRKKASKGERILGVDEPMKRVVKQKSFRMLNGMALGRRNELNVQVADGADDSFEAPPPMPSSPSTYILSSPASINSPLQSPINHTYPGNYYSSPSNYPSPLHDFGPPLPSTSNLQSSKENVKPSQSSMSSSWKKGMRKLFKSKSQAALRQSPKHSDQPLPPLPTGRNNYVSHTPPTGDRRAPLGELKRNNIMSFFAQSTPGGNERGFTHPSLPPDPFESHLDIAADPSVLRPPSPLRPKLRSNSPSLRDLKNMLSLPSRPKIAKAKSLANLRSTSTKKINPELEEMPVRRIEETDTVRGLVQRPDVEKKEDLRSSPQEPPRHPRLDLPAPSPPLLPPNPPYMTRSTSCGPTESGTPPDVPLPPAPIATPLSDSSSSTSPIKRSGSTPMLLPRSRSTSMSLKSPPTSSSFFDLYEQLGIWPKGEKEEKKDDGILGKSEESVKSSPEDTLADGTVEQCSSKASPAADLIPTKTMSLSSPVMGASSCAWGPVLGHVSEGPSSPASAHGPPSVDASPSGAAAKLDQQQQQQTSLSNLVGPSEEEVNPAEEITPNAKPSSSRSSDSYPAALEISTFTVDPRLSSDTQPTSVAMSIKNSRVSRRFDVSTDPSSRDEARENLDMGGTEKVDNDEDDLPLSTIHPNAAATQQQRRDVRQTPERSQTLSKVKVRGRNPGGDTDWDGEGGVPADVLTTKLEKALVMMEKVDLMRSVSHRHVSQADGKPVVPLQINRRPTWSESLAARELSPLDAVSKRPESPLPPIPKPPMKLLSAIVVLDKSTKQITFELQPKTTARDVLVDACKNGDLKEPKNGMSWVLCEVFVEMDCERYVREYETLQSIISGWDISKGNRFEVRQSARGGTTSAKTVPTTPPMYGAWVLYETKKGKWSKRWLETRGGHVFLSKNGKGRDEVHLNALFFDVYTMLGDYDKKSYVFTLKRGEISVNFMDLSEYRYVFTCDGKEAWKLVSSIYDAKSYTLAQAHPHEIAAQRTAQLSQSPGNLRAADKASVLSSSRRLVELGKQGGQKEKALPVMARGLPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM16</accession>
    <name>A0ABR3BM16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="6" type="ORF">I308_105096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612201.1">
        <property type="nucleotide sequence ID" value="XM_066759554.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991952"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0243834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="338" mass="37696" checksum="10E14FB62B0DD43D" modified="2025-10-08" version="1">MNRQQLCRRLYIARSTTALPAARIAACSITTASSSTPSSNASTFSTINASEISHFSKLSSQWWSETGEFALLHRMNPVRVEWIRQKVALAPPPDEEWSFETRHMDAQREAARGTGAWLTGLRCLDVGCGGGILSEALARLGATVVSVDASESNIGIATTHASQDPYLAKKMEKGELEYRFSTAEALRDAGEKFDVVCSMEVLEHVDEPGEFMKCLGQMVNPGGHLLLSTISRTPLSQLLTITLAEDILRLVTPGTHTYRKFIKPEELRRFVYSDMGGFETWHRNDDASDIRENEVGETRGVIYDPLKGAWRLWDGVEGSWWKEAGEVCNYMYHAKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMB5</accession>
    <name>A0ABR3BMB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612305.1">
        <property type="nucleotide sequence ID" value="XM_066759658.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992057"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46201:SF9">
        <property type="entry name" value="PHD FINGER PROTEIN MALE MEIOCYTE DEATH 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46201">
        <property type="entry name" value="PHD FINGER PROTEIN MALE MEIOCYTE DEATH 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="690"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="459"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="884"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="950"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="980"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0243938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1007" mass="109720" checksum="D8E1DFEAC4622F94" modified="2025-10-08" version="1">MCEYGGTERIKAIAAERRLPAQKPPPYDGPNLFPAINLSSNLLPPPSSLPPLVAHTSRAPLLVPSLPLPIAEDTPHHGSPAGQRHTGQKDTVTKLATSVYKLASDPYVPLLHHTFLSQHCYRSPVMAGLVIYDTPFDPAMPNSLGQELMTDWNPTLGSFAGSSRRRKNDMTEHTIRSPYQNSPESPYLQGQTVIITNPTPYHLPYPTISGSHLQPVAPPPHRHPVSHLAQPQNYYPHPSDDARAYAAWQSGSPNGFAESSFQHPMASGLAVPFHYAPNEEKMSKKKKGKQPMREAEAVNKSRALKRLRSADSLRSSKKLKREDGTQSQLLTPPSTSGGEIALTPAASHIQAHAEDMMTPIDEAPEILVENESARTQDDISDPSAKSSHRPLVITRHHEEGRKLGLLGIARGELEESKSPEEETKSPRLKTIDVVETDESGKASLATKDVLETEIPWFEENGKVTPPSSPARPQLQTPAAIPTTTRGEEEADDLPEVNSQKVARRLQSFFESPVNVIEQPLVSTRIEMFGRVAVRKSTALSFLQLSTTDSAVEEMKMGEESWGEHLGISPVRATLRPMWPDDEAPWALAGGVMKDRLRREEGEKEALLRRYLEMSSDDSEDEEYEPVYPFSLPSTTAKGKWGRGRGKTVISLMPEEIRECRRRRDDGSARAALLGSLRSRPVPLLPQGVVACVCGNNNANGMGSMVSCAACKTWHHLVCNGIDDISKIGPNWWCSSCNASASGMRTPVHSYTPTRSHSTLGDPRSSAVKSDIDHIALAPSPMFVNNVSSARTPVRGTQQSPQRPRHSRILSYGSDMWAFQEDVVPPSTPVPVLQDRYSTPRINDTPFDVTSTPSRHLDFNFGQPSLFALTPLGGRSRVPSTMLIDGTPVLRATPRNVSGPGGPLEPMSVPSRADFFRELNKGNAPHSAGPSLSLHPSGAASAGAGDRENTHATSSPRWPSLLSAHNLSPSPFGGAGHRRTLSGNKLSSIRSSSRSGLGMGVPEEKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMC8</accession>
    <name>A0ABR3BMC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="2">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_105218</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612322.1">
        <property type="nucleotide sequence ID" value="XM_066759675.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992074"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="15">
        <location>
            <begin position="211"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="239"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0243955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="544" mass="60094" checksum="D8C5D2FA7DA1F4B3" modified="2025-10-08" version="1">MATEEIHSLYDTILILDFGSQYSHLITRRCRELNVYCEMLPCTQKISELSWKPKGVILSGSPYSVYAPDAPHVDPDVFNLGVPILGICYGLQEIARVHGGTVDAHTHREYGYAKIEVVKSGKKDQDALFDGIEMEEDGGLQVWMSHGDQLTSLPPHFVTIASTPTSPYTSIAHESKPIYGVQFHPEVSHSPRGKEVIAAFVKNICGVRDGWSMESFIPKEIARIRQICGEKGQVIGAVSGGVDSTVAAKLMHEAIGDRFHAIMVDNGVLRKDEAKKVHKMLTIDLGVNLTVVDASELFLARLKNVEDPERKRKIIGNTFIEVFEAEAAKLEAAAEKELAEKGGEAKGKIEWLLQGTLYPDVIESISFKGPSATIKTHHNVGGLLEDMKLKLIEPLRELFKDEVRALGRLLNIPEHLVGRHPFPGPGLAIRILGEVTREQIAILQHADDIYIEEIRAAGLYDQISQAFVALLPVKAVGVAGDARTYDQVVAVRAVSTEDFMTADWFVFPPQVLKRISSRITNEVKGVNRVVYDITSKPPGTVEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMD5</accession>
    <name>A0ABR3BMD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611938.1">
        <property type="nucleotide sequence ID" value="XM_066759992.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992393"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="190"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0243571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="312" mass="34242" checksum="570AF2B358C4ECB0" modified="2025-10-08" version="1">MPIRAFTPGLSLRLRPQVRLQSKSYTTVGAHIPHGHAHHAHHAQRVPYKKPSALRKWGIRLALAIAFPATYVLGAAFPPQLVLLIFPRFSPPPPHKDSVRGKAHTNDVEDCMQKLQLVENMRKEIQAGGEWYETRPYDKYDPQKVHNSLTAGTLRGPGKLAIPPVLFAKKDESEAVAIIHLGRALCGHDGIVHGGLLATVLDETLGRNALLNLPSRIGVTANLNINYRSPCMADQFVVVKTKLVELKGRKCTAEAKMETLNGEVVADAKALFIEPKWAQFLASSGVTEAMGRPLAQPENEPGLLDNDVEKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BML7</accession>
    <name>A0ABR3BML7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611520.1">
        <property type="nucleotide sequence ID" value="XM_066760216.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992622"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046893007" evidence="1">
        <location>
            <begin position="19"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="228" mass="21077" checksum="6142971C2B81BBB0" modified="2025-10-08" version="1">MHVSNLVALAALAGSAAALSINTPASIVECQPAALTFGEGTAPYIIAAIPGGQVSAAAIETINDNLSSSPYTWTVNLAAGTNITLKITDSTGTVAYSSPIVVQAGSSQACLNASASTSGLSSAAVTTTQSSVAGGAAATTSASQSSAAASSSSSAASSSSAASSSAAASSSAASSHAASTTSHSSAASSAATSAAATSAGSTSGAFPNAIVGVPALVAGLFAGVAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMM1</accession>
    <name>A0ABR3BMM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612401.1">
        <property type="nucleotide sequence ID" value="XM_066759754.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992153"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="199"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0244034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="39734" checksum="67B9C083B55E18BF" modified="2025-10-08" version="1">MVADNEFKGWAGLDEKACDGHMSFQEFAPKKWDEDDVDVKILYCGICGSDVSSLSGEWGPVGDICPQVCGHEIVGEVVRVGSTPENGLKIGDLVGIGAQSDSCRECEWCKEGKENYCATQTITFNYPYNRGPNGKGSIARGGFAKYWRGPSKFAVPIPSDLEPDVAAPMLCGGVTVYSPLARFEIGTKRKRVGVIGVGGLGHMAILFAKAMGAEVTAISRTDAKREDAFKLGATDYFATGNNLQEAVKAHSRSLDFILCTINPENFPIADYLPLLTPAGIFCIVGVIPTPLQVPAFPLIMHSACIAGSNIGSPKEIAEMFEFAVKHNIKPWIQKWNFDDINKALPSFQKGDPRYRFVLVNADNGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMN6</accession>
    <name>A0ABR3BMN6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="5">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612428.1">
        <property type="nucleotide sequence ID" value="XM_066759781.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992180"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046617268" description="alpha-1,2-Mannosidase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="8">
        <location>
            <begin position="767"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="895"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0244061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="940" mass="103950" checksum="29B16BC531E335DA" modified="2025-10-08" version="1">MLPSRTGWIWLVACLCLPNLLGVWGMTSARKIQLRDETSALFKHGYEGYIKYAYPADELRPLSCAPLRRSKNAADFGINDLHANVSLTLLDVLSSLPLLHPHALPSALERITTQVSFDQDVKVQVFEMTIRALGGLLSMYQYLDDLPDSPYEQVKVLGIVREGKEGWLGLGLGAQEKVDKVDVKKYKQRILELAEDLGKRMLPAFNTKTGLPYARVNLRHGVEKGETVETCTAGAGSLILEFSLLSRLTGDNRYEQLARNAYYSIWNRRSDHNLLGNTIGATHGHWLMPGLSGVGAGMDSFFEYGVKAGIMLGDDSFYDIFYDSYAAIQTHVRTSDGFIYRPIHTRLLQIPSPTTIDSLSAFLPAIQVLAGDIPSAIRAHLVFWNVWRKFGALPESWRWQERQIEWAGWPGRPEFIESTYYLYQATKDPFYLRVGERVLKDLARRTKTSCGFATIKNVLTGELEDRMESFMLSETLKYLYLLFSETPFPNQNKVFTTEGHPLYIPQPLLQPSTNARKSLHKGEWLTCPAYQSSFAAGGIDFRETDNVGSRGEKAGIIVGIEGTSEYEYARALVFGWGEEGLKVEDQKRMWFDGGVCSIQEVPKFAFDIVLTTPSNQTLPEDPSPGPDKVYQNTTTGDYVINNITGIRLGVRWRLDGQGYDVSSIGPHRVRTGQQVTVIDTSMRNHFPLPTLAPGPSQPEYEPTEVILRFVFLSPVIVKDKHLEAGTVFLHALGATATFGKDFGALATSPNKEDQQGWQLDGGALPILVPPNPSDGCSPLTLSTPDRPFILLLDRGNCTFAEKAQNTETVGASGLLIVGYPYPPEGGVTEGDQTVYAVPEEGMLRPSAEPNEVEGLDSMGIVYMEHLVGELVRNASQKGEVGAAIMRIQGVGEEAAGSSGFPQAGSRATKKHLEGDSRTREGRLAVGDWEICNLMIVETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMT3</accession>
    <name>A0ABR3BMT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612470.1">
        <property type="nucleotide sequence ID" value="XM_066758983.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991365"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="65"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0245386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="224" mass="23483" checksum="D5A377E4C8177D83" modified="2025-10-08" version="1">MSLRIGITTARAIPTRSIASRSIMTLRRVTVPQASPKGYRQSSILQETAKTAHSAFANLAAASPIKKGDKMPDVEIKIDGVEGKLNLGTEKGKNVVVLVPGAFSGVCSSQVPSYITSYSDFKAKGVNNVYVVAVNDIFVVNAWKDKMLGELGSGKGEGVKFAADDTAALASALGLTFDAQPVFGGPRLKRGVLVVNDGVVEYVGVEDSPGDITVSAADKVIKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMV8</accession>
    <name>A0ABR3BMV8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612331.1">
        <property type="nucleotide sequence ID" value="XM_066759684.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992083"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="143"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="336"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="482"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0243964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="765" mass="84923" checksum="F1D2D252521FF11D" modified="2025-10-08" version="1">MATGFQPAETFISFEQPASPPSEDNEVSSSARKGKRKASDTPAPGEKQTKKKKKEKKKKGNKKPQPVEQPDKKDGLPGLSKKQKKALKEQEHKARNGDRKRGNNRGIEAGPRNKKEEEKAAERHAPWTELVDVDLCRDPVDLLTEEINAFYKYVSPTREEFEVRLFMIELITRTINKLWPEAEVTPFGSWQTQLYLPQGDIDLVVAHKYLSDANKQRLLAELGKAMRQANITDVVAIIARARVPIIKFVTLEGKINVDISLNQGNGVTAGKIINQYLDALPGARQLILIVKYFLSQRSMNEVYTGGLGSYSVICMVISFLQHHPKLRRSEINPELNLGTLLIEFFELFGRNFNYNDVGISIRRGGFYFSKASRGWMKGQSFLLSIEDPQDKDNDISGGSFGIRQVRNTLGGAYELLSMRLFERAEEMSRNARGGRRGTSWKDKDGDDWSILGGVMGITKETLKQRNELTRIHLQGRLHHKLSIPLGADPKPYVQNYRPPPVISVPSVNDHGRGASSPPPPAESSRRNKKDVGAIMVEDDELGSDDDDSDSDTSYSSSDSDDSDSDPVAISPPRIKSRSTSHLAQEDISDTDSDEIVEIPQLFESSRRGERPLGDSEPSEDEIEVLSNPPEESRYAGGKGKGKTKVKDAFGPPTPPLPGQEGQLSDSSRPPTPPLPHGEEEEEKDEIDSDEEALRRILAESDGDLGSEDEIGKEWEGAIQVDSDSDEEEKNGRKRSKRGIGSEARRAFWAAKGVNRLGQGSGDISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN41</accession>
    <name>A0ABR3BN41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612391.1">
        <property type="nucleotide sequence ID" value="XM_066759744.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992143"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF67">
        <property type="entry name" value="MFS MULTIDRUG EFFLUX TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0244024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="359" mass="38665" checksum="00172CAA7AF41FA0" modified="2025-10-08" version="1">MRSRPLYQAANNITYGLGAALGASLGGILSDSIGWRFAYFLPMTAITLFMLVINLGGSIIPWSSSANPILFVLSIIIALAFFRHEKRVKLPVLPINLVTNRRMVSQVGLNLFGAMTIFGTLYLIPVFFQTTLVTSASVASRRLLYPTLTAPIASIVTGIFLHRHPDKCHVGQRLGAISLTAGALIMFALTFSNNESKGEWYFIARLICVHAGMGVMSISSLIDILSISGTDHAVATSLVFLLRSIGTMLGISISQAILQNTLSYQLITYVTGPGSKPIICGIPKSVDYLIQLDPARREVAVKCYVLAFRGAFGGLVRAGVCVLIATVLGIGTRENMPEEEAVDEEMCNPPLSEGVPVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN97</accession>
    <name>A0ABR3BN97_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">I308_104667</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IND107</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612619.1">
        <property type="nucleotide sequence ID" value="XM_066759132.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991523"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0732">Signal</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046539824" description="Autophagy-related protein 27" evidence="19">
        <location>
            <begin position="17"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="20">
        <location>
            <begin position="17"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAL0245535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="275" mass="29367" checksum="3CBD840EF706A9FC" modified="2025-10-08" version="1">MRPTLTFLAFLPLIAAFDCSLTASSISYDISPLTGLRTASKDSSTPPTTSEAKVSMNLCAAEGLGKEDGVADEDQCPENTRVCLKLVNHKPSSSEPDRVTAVVPFWLVDTPDSDITTTPLGKNGEQGLKITVEGQEYAGLRQSVNLTLLCDTSSDSPNPTLVSYTAGALSLEWATPDACPRSGDSSSPSSSDGGGSGFFSFVKTLFWLIIIGLILYFAIGIFYNHQQYSARGWDLIPHRDFWREVPTLVQDLVSHVMANVRGSGSGGRGGYSSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNA9</accession>
    <name>A0ABR3BNA9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612634.1">
        <property type="nucleotide sequence ID" value="XM_066759147.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991538"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="1">
        <location>
            <begin position="431"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="534" mass="57729" checksum="96266B3660258947" modified="2025-10-08" version="1">MRIPLDVAHSVVRALHTIRADSAAGNVTQASVQIPNSQPAWAQPLSPNLAAISIEMDRWQDWAGQKVGQPNQYVNQVLTNLGERTGAMPYLRVGADSQDRATIDLSFEVMNATFPTPTAEVPIPEAAHISIGRDFYALSGNLPNGTPFQWGVNLASLNRTETVAQAALIADAFQGDRAHLTANVHLDGLEIGNEPDFYNGGKPGFDATWTPVNYTKTWVDYARGVSEVIQLGGDGPYLTPCAFTGFNAPTWTPQAAIEAGLLYDGDIRAVIKQINAHVYSGAFGYGYPLTPVGGLMDKTTVRTNLTMRANEVTAAKSEGLQYVFSEGNSYANHGQPGTSNTAESAIWGVDWMLQLASMGVERMHFHHGVGYRYNFFQPVAADADFNDGLNLTSRAHILPLYHAALIVNEAIGTNNNSYVAEISTANDNVVAYGIWENEDLVRMVVANTQVYATDNEAAQQGRNKFEVNLVGAEGRNATVKRLFVPQTTAMRGITWAGQSFDTEDGKPTGQVAQESLNNGVLEIEASSVALISFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNG4</accession>
    <name>A0ABR3BNG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612692.1">
        <property type="nucleotide sequence ID" value="XM_066759205.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991598"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="904" mass="99942" checksum="1D983180E186FE3E" modified="2025-10-08" version="1">MSASSSSQRLPLAGPSATATYPTQLPQTATPLIETKKPSQNLPKRGYRACTNCRLRKARCDLGDVNAPSEPPCSRCRREQRDCVFLPSKRRRRTSVADPALREGSLDLPQAEIYPAQAAARPSSANAYSTGTQGAPNVSQTPHQGPPLASASVVDPSFPLLPQQAPNKVESSGRMSFTQTGIWNDAVQHTAGAEDQGKHQVIPGPATYPTMHSVSSTQHHTATNTPGSLGGSSGASTTALSPPYRTKKRKTEPSNRKIVNANLSNEMDALEILANAATDGDDEGEDIKRKQLHDPKKVTWKVGEENKAPLRELSEFHLIKAGILDEHGLHAMVDNFFRYYHPALPIFQTARIPRCREQLLDLAHNDSFLLTCIIAVASKHPSDSRYKDVHDRTWAVIRDAMSDYSFNGLPGSVGFVEGVLLLAEHLPRERGTPPRRTSVDMLAGPGTESAGVHGTDNRRSWSLIGLAIRAAYLLGLDQISLEIDESSRTPDAERARSVWTWCYLYDRTIDTCCLAFWSRGPALCFVGYSHISQTGEIAARLNFPLQLSPGAELDGTAHDDSASLMQSLVELTQVMTNAHDILYPSKLRTEVLVKQGEYFLFLDHFRRALDSYRTIWKPKQWSNRTLEELSWMTFHYVRLYISSFGYSAHIKRAQWRGDKEFSTSRDGSRQAVQLFPRGSATSPDALYIYDSIAAANEILHIALRLAQMGSLRYLPSRYLINISYAAVFALKSSYSGAVEEKDMHRIRELVDHVCTGLVLSCPDKDHPAVRYGQMLRMLSKRLEELHDASAVPSRYPTPEPIETSTNSNASPQTSYDQSSLFPWLAPANASTENSAPTPAFQLAPFPDMSFLPNSQVNPDYLGGNNAANSEPEAMFDCGDTNFDFDLKGFWDDFTLGEGSGFPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNG7</accession>
    <name>A0ABR3BNG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612696.1">
        <property type="nucleotide sequence ID" value="XM_066759209.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991602"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF1">
        <property type="entry name" value="RECYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1022" mass="114404" checksum="C53236C6FE5AD7E4" modified="2025-10-08" version="1">MDKWAPIAPSKPQFQSASHLSNRFASVLKSSKHDPRPKAPAQFIGKWPEDVLLRIIELLPIPDLPNTARVNRAFARLVRDERGWEWRCSLLEIQPEPTVPSSSILKDNELKPPISTKRKSSFPARQASVLDDDFGDFAEQNKDVFEDVDFGDFEAVKPTIPQGRSGPSTQQWDTSKERNLLDFDDLPLPSRPTGSSGSHSRTTGFFALAPSMPPPSIPCTSYSPGPYYLAYKTHHLSLLPFCRHLRSSPSPSSTLSLLFPPSSTTALLPSLSQQSSILLSLIRFLSSQLQPLRDWGFLRQALLAAADRFDSTCLVAFEVSDGKKDVEGMKEAAESSWNVWEAGGGDREKWECGRVWVEKREVFYDTARWDSLENIIKVQAKSGATVRQLDFTPMDAFMSHVLEAFRIDAETAHSVFPPKAKVVLSFCDRLSNEVIGEYIHPLLSQARAISQDLFLRATAATFVQAWKLVDVTMEVLGDEQNVIKKEQVEDSVFHMFEEHLDDYLDDETERVKDHLEDICRAWEQQLGTSDSAQLSKSHAPTFLTSANPDQVKRNVLASFKDALLLPVTIVPRTVTFGVNAIVSGGTQAVSGLAMLNPQKWTGKGGVVKEVKEGEEVVFEVKDMDEIEETANDEIMEGVRTSENVENVKEALEPNHGVSLNDVNARLAAGSLETSHPSTPSPTQQNNKSFDRLQLLVSLDTALELIQVDRDSLKRAETFAKYPGKVGLKVKEAIEEIFIFLLKAVGDRHIAPGFKIATNEMSTYKPAEHEETTSVAPLLQFFELVHIGDTIQSMVQVYFDKELSPYVDKTDFLNAVMREKKRFESVLDDAVAAGLNAGIEVLMNQVEHIILVKTGPREYYPVEGTPMELGPTQGCKEAIACLEMHCNLLKGSTSKEVLEVFYQEVGIRLEAIIQRHIKRQIISLEGGFQVIADLNAYYNFVSSLKQQRITDDFSDLKMLGNVYIVSDARDLAQIVRDVSRYGGAFTPEDIYEFIQRRSDWKKIEKTVDKAMYALSVREDCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNT0</accession>
    <name>A0ABR3BNT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VPS4-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612505.1">
        <property type="nucleotide sequence ID" value="XM_066759018.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991401"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20431" checksum="EA98A15ABF2B7EAF" modified="2025-10-08" version="1">MASPALQKPTTPGPLHNVYYERKVATEKPCYICHRPTTTVLTTLKMEDWLYTCDGHLSDPGFASLIPPPTPASSTPAKPSAEDIRKVVAQYQARESAKSKSAAGKDKGDGSGSKGQDKEKEKGKESPKSPASPAPASTPTPAPTPTHRKFALHRAIFDMRRNELKRREMGVKAREVGRGLPQVPRTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNX7</accession>
    <name>A0ABR3BNX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrodipicolinate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612691.1">
        <property type="nucleotide sequence ID" value="XM_066759204.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991597"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="43843" checksum="36A2822240965338" modified="2025-10-08" version="1">MMTKEERRHRPVTPGTHLPSRVKRIYCKHQLSLSCLFLSVHSQVSHLFPPKLTVKSTLETIFPVMATINTSNGTPSRVWAGGPSVPLITAMNDDESINYDALAKQTVRLAKAGLGIVLLGTNGEASHLSPEERKQCTIVVRKALDDAGFVNEPLLVGTGAGSAQTTIQVTKEAAAAGASHAIVITPGYFSFAMGRDRKAIKDFFRKVFDESPIPVMIYNFPGAAAGIDLTSDEIIELSNHPNCFGVKLTCAMIGKGHRIAAYTQSPEYLAKHGSFLKSCTATGQFQVLPGFSESTLPALVSRHTGCITGTGNTIPKTIRRLWDKSVAGLQGDPKALAEAMELQDRVAEADWTIVKAGIQGTKYFLDHYVEKGLGGAVRLPLGAISDDVKKLIEVDLKGAWEFEQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNZ9</accession>
    <name>A0ABR3BNZ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4'-phosphopantetheinyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612874.1">
        <property type="nucleotide sequence ID" value="XM_066759387.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991782"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0245790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="172" mass="19161" checksum="EC8D987C187C538B" modified="2025-10-08" version="1">MLSGLGIDILSLTRFRDFVIRRGAEKVAKRICTPGELVRFDKLARGSVTRPLGPESVHNSQTQLEDKASVLGTEDILDRQVRFLSSRWCIKEAAYKSLSPLLPRPPSFKTFELVHSSTGQPRLDVITEAKDKYVLLSSLSHDAGVVVGVVIAMDKTFHLLRKDGVGIPYWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP27</accession>
    <name>A0ABR3BP27_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612912.1">
        <property type="nucleotide sequence ID" value="XM_066759425.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991820"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="213" mass="23708" checksum="6AFC342A741CA5CF" modified="2025-10-08" version="1">MKYKDSSPFQRYLYITNLPPGLLPAHLRKILAHPPKPNGKRSRKRDTGVKLIQVYTVPTKSKRRKLPKSKWAPPSNLSDPKNSHHPRPVGRLTSMFRTILCLPQAPDLEPLHPSTSTENQGSPKSQLPIASPLSSDIGDRNGTETEVVIERGVGKGGLDGEKSGQVSLVDEDMVDQKLEGDGEETVAYVHFCCERHSELFFLPTEFLELCSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP68</accession>
    <name>A0ABR3BP68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0246989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612950.1">
        <property type="nucleotide sequence ID" value="XM_066758502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990877"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="105"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0246989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="484" mass="53837" checksum="22BF18A4015EB2E9" modified="2025-10-08" version="1">MPKAKNMELSVKHSGKTYTVPVTQEITTQAFKDAISQLTRVPTERMKVMVKGKLVKDNTDYVTLANQKQTVMVIGAAEALPPPPTEQTVFLEDVGDEDIRSDGPTGLINLGNTCYLNSTLQAIRAIPEVHQALKEFTPSSASSSFVPESRVANSLKNLFITIDNTPNAVPPLEVISNLRILAPQFAERDQRGQYAQQDADEAWTQLVQVLRAALPKNGEEGSVVDRLMSIELTKTFKNAETEEEPETTSTETVLKLECNISGSTNFLMSGIQDSLNQQVEKTSATLGRNATYSMQSRISRLPEYLVVHMVRFYWRRDIQKKAKIMRKVKFPLQLDLSDIVTEPIRKKIQPLNTATKQILKERDARASILKRKPGQGLDEEKKKRGEEQATVEDLVKEGGLTNGERSGMYELAAVVTHKGASADSGHYIGWSRIDDGAYIPAEQQRWAKFDDNDVTFTDANKILSMDGGGEDSVAYILLYRAAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPV2</accession>
    <name>A0ABR3BPV2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613176.1">
        <property type="nucleotide sequence ID" value="XM_066758728.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991106"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25722" checksum="56F19F23D5AA99DA" modified="2025-10-08" version="1">MASSEPTPRALSVSSTLSSAIASLENDQNLRKQIKEAMEPIEDLARSAWSEINKIHSAPASQHPDICNSSLEVIKKIAPLWVGVAELIPQGEFYRYLYAVGPTMRSLTTSIVFARFLLHDELTPAFTVSSLIGLEQQETKDLLLSAEDYLQGVIGAVNELPRLSVNAVTSQNFELPVKIAAFVNDIFVSYSLLNLRNDALRRRFDSLKYDLKKCEDVVYDLTLRGLAPAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPW0</accession>
    <name>A0ABR3BPW0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613193.1">
        <property type="nucleotide sequence ID" value="XM_066758745.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991123"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="420" mass="43088" checksum="EEDC60B9A63EFDFB" modified="2025-10-08" version="1">MPFQSSPNDAGTVSVTTQEWLEFQEFKKFQAAQRAKHNSQSTPSTEEITKDLSSVKLDESSIPNGRQSHPQPPAQTSAPVETATSDGGWGEPTSVPVPASTSEDSAGGWDEPSTINSSEACPTEQNEAHSHVTPESEPEQPKKSAYVPWEGGVVYSQPITSPDPVELPPLAFRSKRNKKSKKAKKAKSAAAVDGEGSAPEAADPGGWGETASVTSTPSETSSTPARIHPSRLRMLGGAPKADPVPAGPSHDYGQPQSRRVSGANASAGGGDGWGNKRRTPSAPTNGGVTHSPNAGSFTYPQPDARPAPPSESGSASGTAGIHPDRLRMLGGAPAANSPSMGLGGGSRDNPPHMRDRMDEFGAAADGKPRDNGWDPLSNRAPAAQAPVSNGAGNGGWGQTTNGGGGGWGNDASNSGVSGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQA3</accession>
    <name>A0ABR3BQA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104392</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613317.1">
        <property type="nucleotide sequence ID" value="XM_066758869.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991248"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045555065" description="peptidylprolyl isomerase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="329" mass="35953" checksum="B8FB8FF6843C24D1" modified="2025-10-08" version="1">MTSKSFLSLLVALFAAICFVLSPGADAAKGPVITNKVYFDIEHGGKPLGRIVMGLYGKTVPKTVENFRALATGKNSDGEDLGYGYEGSSFHRIIKNFMIQGGDFTKGDGAGGKSIYGGKFPDENFKLKHTGPGVLSMANAGRDTNGSQFFICTVKTSWLDNRHVVFGHVLEGMDIVYAMENVKTSRGDKPVEPVTIAASGELPIEHEVDEQGNQVDPDQPEGTDIGEPQEETSTKEDEVQGGIVPSEDLDLSSPTEAELNNDNHDDEEYATISSPSKYLIFFAAFVILPVGAGVYFYGGGKERMKKWKWNRFRQGKGKKYQKVEDEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQV0</accession>
    <name>A0ABR3BQV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoglucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613240.1">
        <property type="nucleotide sequence ID" value="XM_066758792.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991171"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046539825" description="Endoglucanase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="30942" checksum="7B36CA05B2D432B3" modified="2025-10-08" version="1">MRTTIALFTSLFAASGALAHLQLSYPYALHSPLDPQTPEENKDYSITSPLLTDGTYPCKGFINNPASDMYSRATWDAGSTINYTLVGTATHGGGSCQLSMSYDSGATWNVILSWMGGCPIDAMTAEVTIPTDAPSGEALFAWGWFNLLGNREMYHNCAPVTITNGGSGLNENDYPTPFVANAGVNDCVTIENTAVVFPNPGKNVKYGGSYASTKPTEPAGFTGSNCVGSGASSNGSSSGSSTSQSTTSSSAAAIASSSANPSASVSAGNASADSSPAAAAATPSSDSCKRKRSEGPRRSRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR36</accession>
    <name>A0ABR3BR36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613616.1">
        <property type="nucleotide sequence ID" value="XM_066758214.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990588"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="197"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="312" mass="33604" checksum="86AC9237CCF31447" modified="2025-10-08" version="1">MRPIAVPYPCIIPRTPGRAILRRFYHAGSSNPPDTADLLRQVMRNVAQPVAVAVASVPPTSPLAPLAKYHGATLTSFTSLTLHPRPLVAFSLRLPSRMADCLRPWRTGGSREESKARQAVEAQSVQAGNTLRLPPKSELPWPLSTLPMPEDPPPWAQSLVSKIPNPLAPSAGPIISSTAPKVPPERSPATLIPPIPLTISLLSISNEAIADALSQPRTDHSSIFALPSTWEETPSTSTDEAPHPPALLGSVGSLQCQVVGSVMLKDLCLPGEVQEGEGSEMFICRVVAVKMGDMSEPLLHWRRKYASVKEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR82</accession>
    <name>A0ABR3BR82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="9">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ALA1</name>
        <name evidence="12" type="ORF">I308_103750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 9">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="9"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613634.1">
        <property type="nucleotide sequence ID" value="XM_066758232.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990606"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="11">
        <location>
            <begin position="23"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="743"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0247673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="975" mass="107764" checksum="9BDC52C867350E7A" modified="2025-10-08" version="1">MGANDKPAVPTTAPHAWPSPEDWPAAKVRQTFIDYFVNQPGFEHTFWPSSSVIPFDDDTLLFANAGMNQYKPLFLGTADPKSELSKLIRAANSQKCIRAGGKHNDLDDVGKDTYHHTFFEMLGNWSFGDYFKLGALTMAWDLLTRVYGLPKDRLYVTYFEGDAKQGLEPDSEAQQIWRDLGVPESHILPGNAKDNFWEMGATGPCGPCSEIHFDRIGGREAAHLVNADDPNVLEIWNNVFIQYNREPSGELRTLPAKHVDTGMGFERLVSVLHNVSSNYDTDVFTPLFSKIQELTGSRPYEGKLGDEDKDGIDTAYRVIADHIRTLTIAISDGGIPDKDGRGYVLRRVLRRGVRYASNKFGVKIGTFFSSLVPTVVESLGPIFPEVTKKIPELIEILNEEEASFARTLTRGEALFNKYATTAIAEKRTVLSGKDIWRLYDTYGFPVDLTQIMAEERGLKIDQEAFEKAKLESLEASKAGGKEKAGAQVKLDVHDLAALEANDAVPKTDDSFKYNLDDIKAGVKSIYHNSKFLNSTSELPPNTTFGILLDRTNFYAESGGQEYDTGVIAIDDKAEFKVEDVQVYNGYVLHIGRMEEGEIEVGDEVICTYDELRRWPIRNNHTGTHILNFALREVLGDHIDQKGSLVAPTKLRFDFSHGKSIAVPELIKIEAICNDWIKKGVPVYAKDMPLAEAYKIPGLRAVFGEAYPDPVRVVCLGYPLEEISQNVEDARWRQTSIEFCGGTHVAKTDDIKDFVIIEESSIAKGIRRIVAVTGHDAHDVSRKGAEFERKLQRIRELQGKEKELAMKPFLTELGQSGISLIKKNSLKEQFEKVQGELVAAAKAKVAADSKIISEAIKTYFQENPNENVFAGSFDVGGNSKTLTAAVAAGKTASKAVYAFSADPETGKVAHVNYLPKPILESKALDAKIWLNEVAKVIGGKGGGRDDSAAGVGSEISKIDEAIVVAKSVYKKRVEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRJ8</accession>
    <name>A0ABR3BRJ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ERCC1-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613778.1">
        <property type="nucleotide sequence ID" value="XM_066758376.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990751"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="105"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="455" mass="49557" checksum="907ADD050CB7233B" modified="2025-10-08" version="1">MTEQNGASPSNGGSIIPSMGPPVFQTASSVLRSTAAQTSSAASASTGSLRNASGGQPPLSVSTSAPSPSTVGSSSMAAAGLGDTSSNAPQISRPINRPAASKNSIIYNAVQRRNPVLSAIRNVGIEVGDIAADYQVGAHNGVLFLSLKYHRLHPEYIHQRIEKMKNMYNFRVILVLCDVNEHHQSLRELTKIAIINEFTVFVAWSNEEVAQYLVTFKQFEHKSADTLKERVQQTYHDQLAHVLTSGKKVNKTDADNLAAEFGSFETISRKSAKSLSNVKGLGATKVTSLIDAFTKPFLVGGLRRSERGKTEQTDKEAATFGDDDIADLTESVELAAGNKGANERYVSDEVNGGDMVSGQVWHDPLDDEDDDIAVGEEPVSKRARMENPIWKSSVKNSRIQRRSIDRPYKFVLNPRSSVEMFFNLGPQSDHQPSSDEKRCHLTLFGIDTERSTLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRL9</accession>
    <name>A0ABR3BRL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613804.1">
        <property type="nucleotide sequence ID" value="XM_066758402.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990777"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="574"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="386"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="663" mass="70493" checksum="A1AAF9631BA9373B" modified="2025-10-08" version="1">MGFNSPIPVRLQEETRKAANILRSFVDVNNNGLDKVIPRTVMERAAGFAIFTVFKAGFLFSARAGSGVVVARLPDGTWSPPSAIGLGGLGFGGQAGAEVTDFLIVLNSRSAVTSFMSAGSLTIGGNLSVAVGPLGRNAEGSGALNSKGQVAAMYSYSKTKGLFGGVSVEGSVILERQDANRLAYGGSPSSKQILSGMFDPPEWADVLIDQLEKSTGMPGGQRWKSRDEEGEGGGMGWSTPEAGRGGGGYVFGEGVGAGGSVGSGRKRAGSLFSKDPDRSNSPSRPGMPRRSSILNPFSSGNSSPRKGSAGPHHTSEAYNAGLTWDSQGSLGVGAGNAGASAGRARSGSLRTDGEVPQPFSYMTAAKLEGNKNKDLLGEWDSATINSTKSRSRNNSDGGDRDLLGQWDSNGHGLSAQFNRLSTSDTRSRSNSRSNRPPFDDILEYPKKPSTSTSYTHASGEPDYNPRESISNFAKTDWSSFEDQQRYDSPSKKTRPFSSYISPMPKSSSSKDFSPFDDDGVGRLRSSSANRPFEDYHHQSDRYGSPSRDFSPRRLSGASPKPEIRLKRGLDTVDDGYARAVALFDFKPGAAGDLGFKTGDVVIVLDYAGDSSEWWEGRLASEGSAGRKGIFPCTYVEVLGLPKDLRGGVSRSDLRRRIARNEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRS7</accession>
    <name>A0ABR3BRS7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquinol-cytochrome C reductase hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_103656</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613543.1">
        <property type="nucleotide sequence ID" value="XM_066758141.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990512"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="10">
        <location>
            <begin position="62"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0247582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="125" mass="13948" checksum="8F06FB06FB982346" modified="2025-10-08" version="1">MAADNMTQQTAAAPVEQQQETSGFFSSFVSYFVPTAHADDSEEEEKEEPAEEEEEEEEEPEDIAPAIREECEKSVCAEHVHHFAHCQEKVEAGDGFPGEDCVEEFFHVLHCVDACAAPKIFKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS39</accession>
    <name>A0ABR3BS39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103072</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613957.1">
        <property type="nucleotide sequence ID" value="XM_066757573.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989928"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="172"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0249770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="416" mass="49616" checksum="61130903379477BA" modified="2025-10-08" version="1">MPGPAVTPKKPSQRRRSSVTSALNQIPLNHEQASSVQPVEEVKPLTSRPRPKSKGKRDALPEIYSSNGFWDDVKTGRWMLIPSSSFKLMLIPPILYLNHCLLVHYGILGPDISNIFEHLIFPSNRLPDGRYGKSWWDLAFMANYIIFWSFVRQFMTLKVFRPMAMSLGIKGGKIMRFTEQGYAFFYFSILGSLGVYVMHGLPTWWYKTEHFWLEYPHREMTWELKTYYLMQAAYWLQQTILLAAKIEKPRKDFKELVAHHIVTLWLVGWSYNIYLTYIGVSVFVTMDVSDIFLALAKCVNYVSDFWSVPVFAWFIFVWSYFRHYLNIWILWSVWTQFDLIRPSERSGFDPLNDNWLSWWMKWQIFTPIFLLQLINLFWYFLIWRILVRAVFYRDLKDERSDDEEENEVEEVKEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS85</accession>
    <name>A0ABR3BS85_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MRPL25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612858.1">
        <property type="nucleotide sequence ID" value="XM_066759371.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991766"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23151" checksum="A50B3922A142C831" modified="2025-10-08" version="1">MSFASSSRTVLARTNIPFIGSTRGVLHRARPPRMPALPSPHNPKQPLPTSGTSHPVPPNLGTPSVLTTVTALPDSGLTFHHSPPPSAPSYTNGAIPDLFRWTAGESVRLSGEEAATALGERRWHGSKVDWSEELVQKMRDLRVQGLSRKGISESLQIPLEEQRLIPRVAPQSREQASAKAEEFAERKAKWGYRKRLARDVRQKRKEFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSC8</accession>
    <name>A0ABR3BSC8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613200.1">
        <property type="nucleotide sequence ID" value="XM_066758752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991130"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="177" mass="19309" checksum="EC524CBF61CD93C7" modified="2025-10-08" version="1">MSHCFSNQDSLDSHCSQLLSGNFLSYLNKGLSQFTDQPLLTTTPSIAGSFDYLDPTTRNTAYPTLFCIIGCFHSISINISISNLLVFYLAAGLPSSKDTGLTKLHLCCHITNIVTFTGLFGPLNKRFKFTRLGNARLEASIRFYPAPGRGFRHDVLEPDLGGMIEGGIRSPVPSALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSL5</accession>
    <name>A0ABR3BSL5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH15-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614138.1">
        <property type="nucleotide sequence ID" value="XM_066757754.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990110"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF9">
        <property type="entry name" value="GLUCOAMYLASE, INTRACELLULAR SPORULATION-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="2">
        <location>
            <begin position="95"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="569" mass="64059" checksum="73414ADBBC36B0EA" modified="2025-10-08" version="1">MESDLLSCQKGLLPRSVTLRPPGSIIEHNDRRHRSVITKGLFLCLLILSAIVTKVSLGLWPHCLNSQSVHVDHQSNHQSLLWESRILANIGPGIGAKEGLVVASPSRGHGKEPDYYYTWTRDSALTISTLISHLRSDLADIDNVTDSWEMYSALSDTLKEYLFRDYIESQAEIQIGKNPSGDLKSGGLNEPKFHVNGTAFIGNWGRPQRDGPALRAITVMIYANFLLDRGFPSDVSYVKQWIYDPRQLKAPGKVLKNDLEEVAHGWSKGGFDLWEEVDGHHLFTLLVSRKALYHGSIFARRLKDVGAADHYLAQAHAITQKLPLFWDSKRGYWLSSLRGRDLELAQIKSEFDPTNIYPRREWLDCALPLSIIHAGSHTLQPIHNFSFPFSAIDPNVLSTMHLYIKSFDGLYGINDGRSWLDGWALGRYKEDVYDGKGHSQGNPWFICTFALAHSLYLAYKEFREVGAIVIANQTLSFWEDVVSISSTPPKVGAGDVWIEGRDRRFTEGMKCLKEVAGRFMEVGLQVAKKNGGRMSEQIGRDDGQFKGARDLTWSYASLLDLIRVRSDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSN0</accession>
    <name>A0ABR3BSN0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614129.1">
        <property type="nucleotide sequence ID" value="XM_066757745.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990101"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="183" mass="18979" checksum="6B4A499FE144C5E7" modified="2025-10-08" version="1">MSSNTPMSSSADSSSLRSRRPITLDPQTPTSSLHSLPSLNSTVIGTSNSPPSDGVELSVPTRSATTNGGPPSATSSNVFFPGGLPLPAVKGVISGIESPRHGRGSPSIGNRRDIPGSPITPTTSITVPAETESAQTTPTGGVVVQREEYKPRVVFRSDPTVKSCLLGLKMEKKDEIARLFGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSP4</accession>
    <name>A0ABR3BSP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vacuolar protein sorting-associated protein VTA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103776</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613659.1">
        <property type="nucleotide sequence ID" value="XM_066758257.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990632"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="471"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0247698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="53901" checksum="614F3EB47F11AB1B" modified="2025-10-08" version="1">MQNVNIAADSVPQGLKHIEQILKRAKELKQTEPIVSYWCSFSAAQKALNVQNRTKEDTLFLMSLIDALEQMKVIMGNNEAIHSEAAGAAYIENFALKVFMSADNDDRAGNTGKATIRKFVVAGQFIEVLRCFEHGMTDEMEQKLQYARWKAADGAKALREGRTPKPGPPIPEDEALLPAPPVGSPDALSHDIQLPSNALGGSRNGSFSSAVRPTVPSPPIMSPHPSPSLNPRNHDDVNATPIDTSTADSLRTAEGQNSGSGAWSTIATPGLPDDENAQVHFDLGRTEIPSSDTLGRPPEERLSSDERKSVKFMGPDGAPLSPASMHNTVSSYGAPPPPPPTHIASPVAPSKPPASARSVPVVGNPPDGRPRGDSSASTWSNDRHNQPGTHISDVSAHDAAHGTTSPKPKAAPTSDTRTSPVPSSINVPPAPPPSLASAPSLLPPLHPQSHDLGLTSPPISLAPTPKSLSSRDVEQTQKHAKWAISALEFDDYETARSELRKALNLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSS5</accession>
    <name>A0ABR3BSS5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614194.1">
        <property type="nucleotide sequence ID" value="XM_066757810.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990166"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="31942" checksum="786071BF81A35D4F" modified="2025-10-08" version="1">MHSRLNSISKPFFNLEAGSPFNPASPRSVSPTLAGNDPFHRRFLSKFLADIDPSSVDLISIYMCFLTGLTASPSFAACFVWCGFQTGNAAQLGLAIAKIFTSDEHKTIGFQKMDQQALTSLLTFLMGAVVGQLGNRVGGRKRIWLIGATLGQMLLMMAAALAAHFCGESGLSDSRGDPSWITPIGMAALGFLSAAMGLQGAVGTKLGTPLGTTVPLTSTWIDLFNDPFLFSIKHIRTRDVRALGCFALILGAVISRAILGAIGQAPTIAAAIGFRAILAAWWFWLPNAPLSGEVLHEVGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT44</accession>
    <name>A0ABR3BT44_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTPase activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614306.1">
        <property type="nucleotide sequence ID" value="XM_066757922.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990283"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04399">
        <property type="entry name" value="RhoGAP_fRGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF17">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN RGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="341"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="600"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="908"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="864"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="939"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1144" mass="122594" checksum="0CE15E8034E848A6" modified="2025-10-08" version="1">MAPVTLPPSFYNSFWSPDYRSGLEVLFKNLEQGCLENEDVTAFIESQARGHRSLASTLLNPPLPSTSAESSSSLSHTLLSLRGASSARGEAHLALAQELEERVLLAWKAWVDRHGIRIKEAKAEMLGKSGVIGVWEKDAHKLEQLKKAYLTKTRAADDAEDDAKFAPATSRSPPLDNYTSSPKLPQAKLSGANLRRTATVADRITEKLRGASISSGSSAPGTSPSKHLNAISVDGKVLPPPPSPLKTEDLVGGGSLDSPGSPREERFIPPTDPHGKPTLPGVEPTTHELPSSPDPNVAPILLSGLSLTPRGLKEILQRLDTHLLTTVAPNAEPPTTSSTKSNPALASRQRSTILGSYEKTVSGAEIVTWLADNVEAFGGDWERCADAAGELHKMGYFSRIGVGRGFDAGDDTYFILKVNGPEAVSNQSFALPTPLAPSTATNAIPNIFKQYQSYLPASLANSDEPPHVRLRRDAHKADEMYREGVWSAEEKRLEMEERIERGLRLWERWERERLSAVKTVLKQYETTLAKLPGKLANFQKSTELSVEAFNPEADIKALIEGNRTGPFRPQSHVYESVDTDVPDVNFGIDLRRWSGERGWKSLVHAPKREKGAIPEALEALLGALVEMYEGISEEERRRAWIYEVPLMETHMLRNAINNPKIPVDDLVSIVKKFNAPVAAGTIKLYLLELNPPVMGWEGWEDAKAVYPAVGADQDVDMTSAVASVLGRLPGSHIFALDAVIKHFRTLIDTTKSAEPDEVYITKLSLSVGRTILRPQFETDLTIGDRTPSLFLADLIRHYTALFPPLVEKLKAETDRPMPVKKRTALVDQRVSRSSLGKDVDPQHLLELQRAQMRATSPASKGGKDLPPIQQPQVVPTTPSPAPALAATADSAANPVSALGFGPAIETKKGEEEAGSDEDEPFIPPSDTQPNTSTPSNPLASHRSSVHSVHSVRATRSEGKTDPAPAATSRTTSPISPAATSVSKDTKQVQESEQAAVAAPADGDIVISSGGSAAGLKRGVSGESSRLRGPRAARGPRPAPGRAAAHGHGPSTSVSERPESPQSITSSVGQGEVLGRVKSRPTSIHAGAGAGAGAGAETSRPSTPAAGERPTSRYGNHATGTATGGGHGKRGSVSAMAAKFEKRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTG8</accession>
    <name>A0ABR3BTG8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clampless protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614422.1">
        <property type="nucleotide sequence ID" value="XM_066756953.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989265"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="471" mass="51693" checksum="2FBA6E0385238FAF" modified="2025-10-08" version="1">MTTYLAPRVFSNKENSAVPSVVLNDIDAISLSLRTSLSGVTLAPKKKSAALGLGHAPKFTYRRHSNKPYNRSTSITRAKKAAVQAKGARPKVIARQSKTKPPPLKLTQGPEGERARLERLRKAVWNPPAPIPGQVKIPLKLPYPRFPPFEHIDNEDLKEIPVQYIFDRLVPFLPAIATINLAYRIYASIPHPDPKLLNKANLAFAIPEIVDGSKPHWAGKARGREPDLALAVVGKTGEGSKGNMVVAVNNLVFATQCAYWPRLMTASIPISAPKRPAPSESPVSASLPDIVETEEGDSDASISSSYSDGDSEVQRVDLPRLPRSVKDDKGFLHLPLVRLPIPSPSTFPIIHRHLHHPSRALIPDLLGLPEHCIIRSQILDAISGLSVQQLMDKLTTLHGVWQNFCSLGFGRPGSWQQLGEAWACVVGVIAGHGLLVAGQEEAEMQRTGRKRTAAEDVAWEWVRRQKAKEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTM5</accession>
    <name>A0ABR3BTM5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614200.1">
        <property type="nucleotide sequence ID" value="XM_066757816.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990172"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="674" mass="77430" checksum="17A6E2E216A60FD7" modified="2025-10-08" version="1">MSVADTDDVDGHLLLFDLPQLTPLPDEEYPRRLEERKPDRGYYIAMGLVLMVWMITPMSCAYLLWFILLSPYPHSLTATLFAAYALTEALFAIYLSYLNSSVQRPSPPSNVSDEFRTALIQRVFHSGLRYPIPPKGVLAHNDVDPARRDAVAERAEEDYQKGFISAAELHHIRDREYEESVGLRERQRTGRMTHAERAVIDAFVEEDEGDREKMLRDQIEGNVKPMEEECGYEGIIQNGKIVKLHRWDRRAIEFRERLRTWFNHAPWESIKKVNIQIWLAWSCYGSPLEDVRANKEQSDFINLATELLEARTGMDFEDGFTSKVDVMRLTLDPVNARSRPLILYALTNVMNFWLRRVVYPYQGMGLYREGDIEYLIRIPKNWTPDKGRKIPNAMPVVYLHGLGFGLLQSHLLIKHLIQSLPTHPLLIPLSPHTSQALFHHRHLQPWTRAELITAMKNICRKWGFWDGDDDESKAPDEGGDDREEAIGGVSMLSHSNGSVGHAWILKDCPSLIRRSTFVDPVVFCLWEGDVCHSFCYRKPSTALELLLYYFIAAEVGIANYIQRNFDWTENTLFIEEIPHATDPKKTAFFLGGQDMIIDAARVRKYLERHGVTSGLHWDATAGHGDGLIGQARDRVVMFVGTGTTKWQNWLGTGRRRHSLGMKDLRERGGIRKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTN0</accession>
    <name>A0ABR3BTN0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyruvate dehydrogenase X component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613338.1">
        <property type="nucleotide sequence ID" value="XM_066758890.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991269"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="33"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="172"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="36967" checksum="3B4604E63F81BD5D" modified="2025-10-08" version="1">MRTTRQIVGVLRNGRLVSRTAIPGVPIHVRYATTNMAMPAMSPTMTEGGIASWKKNEGESFAAGDVLLEVETDKATIDVEAQEDGVMGKIIVQAGAQKIPVGQVIAVLAEEGDDLSSITIPETPPAPEQPKQQEAKEEQKSSEQKSAEQKAREQPRDERTHREHKEIKHPKPLFPSVSRLLQESSLSSDEIAKLKGTGRHGMLTKGDVLLALGKVKNRYGSAEKLNVDVMGPSGKRLSEAGEGKEEKKKEEEEVLDGPALRRLVVKGMAEATQPAHPIIHHETTQLPRSSDFEFDSILAPYAALLPSPQPEIKIPSRDELLSSEGHLAHPKKDAFAGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTV2</accession>
    <name>A0ABR3BTV2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614290.1">
        <property type="nucleotide sequence ID" value="XM_066757906.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990266"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="61"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="183"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="397" mass="44918" checksum="DA451FE2B5D7053B" modified="2025-10-08" version="1">MDFRRFLTTLSCASLAKIDNEYTPRTKDFLPGPTTISSPKSSTSISKRNKHTQQLSEKASGRILVLQEFIVSEITYVYLLQEFDHVYIHAAYEPLPSKFGSKISPDTTFGTILTAEERKIMFRGLEEILKLHSQYILPRLVDATQDVLQGIDDLEDDRSIKAVINICKQETLPTRHDWLSLLPVQRLTRYKMLLEQLEKFTPSPPAGTHDYVKDVIARISTVLAYVNDYKRVLDSSSRLCHWADHISLAGPSSLVQPQRILIREGPVNFIARGAMMKAPSGIRKPHKNMSRDIATVDKMCIAVLCYDLLVLADSTTERYKGKLRLVDVVRLSAMGDARVEWGNVVVFEAYDVTYYLQVDNQNVAEGWVQAINHCRRNKGPITASTFPAQLKGFGYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU43</accession>
    <name>A0ABR3BU43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614652.1">
        <property type="nucleotide sequence ID" value="XM_066757183.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989499"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="62"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="331" mass="38948" checksum="CC79D8A8EAC409EC" modified="2025-10-08" version="1">MRLPLDIYLDDTRSSATPSLYSPSDSEDERSSTFSSSKSERRRTSNVSRKRRRERSPSKDVFVVEHILARSLSKWRNPESNKYEYRYLVRWENYKPKDDTWEGQSGLMEGSKQLLEEFESREYQPFTILASKSAPSKPTMYLVRYGVVNDSISPSPLYEKVWHSASQINRVGSIPKAVVKDAIDKYEEMERLQEGKGLARGASPRPLQLQKDKCMLDILGRKEEGDEDRPTVMFHVRWRDKWKLKEEWMNYEKIVFTFEEDGKQFLMKWEAKRGYTKTTGVTTMRLLEEPDNMKRLATSSHGKERQPMTDYELERLKNIEANKELMRQLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU88</accession>
    <name>A0ABR3BU88_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102682</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614691.1">
        <property type="nucleotide sequence ID" value="XM_066757222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989538"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="874"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="423"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="879"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="898" mass="99764" checksum="E830414291FF9106" modified="2025-10-08" version="1">MDNFTDKSSEVLKAALDKAGEMANAQVHPLHLISVLWEEPNQPSSGPDQPTLLKAALEHVGGNPTLFNRALMHKINRLPVVDPPPSPPLPLANSFNAVIREAQKLQKDQNDQFVAIDHLILALLHTDASDMKELLKGTGAEPKALEAEIKRKRGGRKVDSKGAEGQFDALNKYCVDLTALAEQGKLDPVIGRDNEIRRVIRILSRRTKGNPVLIGEPGVGKTAIAEGLAQRIVDRDVPASLISRLLALDMGALMAGAKYKGEYEERVKAVLSEVEKSGDEGTQIILFIDEIHLIMAGKDSSGGMDAANLLKPMLARGKLKVIGATTLNEYREYIEKDSAFERRFAQVIVDEPSVPDTVAIMRGIREKYETHHGVRIMDSALVLAAQLAKQYLTARRLPDSAIDLLDEAASAVKVARETRPEAIDELERKKLGLEVEIHALEREKDEASKERLETAKKAIADLEDKLGPLKREYENDKHLGDQIHELRRKIDELRAKADEAERRYDLATAADIRYHSIPQREQKLKELEEKEAEKGSGQQVAPEMIAEVVARWTGVPVSRLVETEKAKLLRLEKLISKKVIGQPEAVKSVANAIRLNRSGLGNQNRPIASFLLVGPSGTGKTLLAKTLAGVMFNSEDAMVRIDASEYSEKHAISRLIGAGPGYIGHEAGGQLTEAVRRKPYSLILIDEIEKAAREFHQLFLQVLDDGRLTDGKGRVVDFRNTIVMMTSNVGSMYLNEHPSEGAVDPEVRAKVNAAIAKTFPPEFINRIDDIILYRSLSRADIRKVVDVRLKEIQQRLHDNNRKIKLDVDEPSCEWLAQAGYSPTYGARPMARLIQTEILNPLSRLLLQGRVRDGEIVHITVDLRKNRLVVIPNHEPDVIQPDDSEDEDDAMDIEVEEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUE1</accession>
    <name>A0ABR3BUE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102738</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614747.1">
        <property type="nucleotide sequence ID" value="XM_066757278.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989594"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="347"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="438"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="652" mass="72421" checksum="21E2841D44508E56" modified="2025-10-08" version="1">MTHYVPTSFKPMRSLVAAAGIQLSPSSPSDQDEGTIEAEDGELLLGNIIIDEFPADGDLPALEGEHFQPPGLFSTSMMPKIINTGGKLHVELKTRDDEATVSEKDQGEGLMLPQHVLLETSSAVQDAEDGGDDGEGGHHSLGGDDFLEGLHFVDDDITRGSRRYFNPEPEDDLEVEATFLSTADSRKVCQNCKRPGHQASKCPHIICTTCGAMDEHERRDCPLSKVCYGCGRRGHHKSECPDPISRNKRWAGCERCGSREHTDKNCPTLWRIYTYRSDSGRRDAIKLKEKAEGWMKEAIGGDAMEDWCYNCARTGHFGDDCPQRRGSLVRLTAPSAFSREIARRGPFFSAPKSSLPTPTHSRWEDDDPSAIPYTSAYDSFAGSNAGHRGREKEKQRMMARDSDFNDEDDWFSGERNRNIGKGAGTPRNNPRGGKGGKRPWDSEMRGKEWDRDRYDRERASRESFDRDREPPRSRGRASSRRRSRSPNRRDGSRHNAMQEAAPNSAPPKAVYRPAVKMGDGPMDSPSVREGERGAKAGSKALVSRALSGQNSNNSTPRGRKSSNSPSALPSLLSRIESPTPSNSSSRRREGRGKEQERDWENEWRRRGNGGGKVASWGKDFDKEIEGLTTKRKTKEDGTSRGSSGQKYYGGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUL8</accession>
    <name>A0ABR3BUL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614811.1">
        <property type="nucleotide sequence ID" value="XM_066757342.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989663"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1142" mass="120542" checksum="F2EBC179B8C9C60B" modified="2025-10-08" version="1">MPKPTFIQTVLRKPARSYADPHAPLPWSDNYHDADRSALSRRAPVRYSLRSASSDASLGGFPKPGEPTSVVLRNGEIVRAPVKESLSEVGTSAASSVRRENPLAKPAPAKAIKKKRKTKPDHSHASLPLRVPADSTPALHSRLSETSSASSSPLASSQSVTPIPRIIDRSESDSEDDVFYTPRSSFSFSFETTSPIAIGPHAESIQLPDDAAMETPKAVETPEPNLIPITTPKPKTETAFRSATPPVFNLLPPTPAPVPDPTSTPFHSHPPSPVPVPVPIDRSSLHPTARPSLLPSRLIIPSRNTMEPTAPSAPPPKDEEDMESASGQAGSDHEMASTRNTRPSSRAQSIRSSSRRHHPPRTSLESSRPTSEASFGSGTASVRDGAAASGGGSRQSSMAGFGKGGWAAAAASASGGGGSRSGWEGFQPAPVGAGGGPGGGGGGARQSRFTPLPAASLPCFDKLVNSPSVYAATSSIGSPSNASASASPSGNDKRGKNGVSYSSPSEYSQASGSDNWPIPSRSYAKHYTRSDTASQSRSPSPTPSQHSSHATSPPLPPKSPLRHSHSPIPPPSGTSTIRPITPTRGAGFEPPSFLHPDILTVLPEMTPQDSERLYRSSPLPPPPILPERSWARLSMYIQDNGGQASLSRSHSRRSSIFKSSKSEVGLSRANGNSNGQGQGSEAGEEDDGLGELPSPSMIKRSKSAAGGYRGGGGSVGSKTEGSCYADGVLMESHGRDQEHASGYTNLILPLGAYKQSNPAKPTPDLDARILGLPHASMASITLHSTFDHHNATPAHLRDQLPPLVEFSSHAKPPQGGKTGKNQVLVQVYAVAVDQLDVRAVDEKGKGDVGKYVPGRSFVGRALVVGTDEKEVVRGDVVIGLLDIRKSGALAEYILVDRRRVSRAPFPTLLTLEQLSILPLQGIPAARCVRGSLNRQSRAIVINAHTGIAALVCQAMSRAGVSVTAIVPGGDDSHDGHQKCIENGANGVLMGSPAAVMINLEENGYDFVFDTQGGQRVYDTARRALKNGGKLVSTKRPEATLNHVPSHMASRPSGIKTLKTVFASKRKDSKFIVFEYLSPIGSGEPEIDASGMDTRDVMEEPCMAIFKPVFEGENAVVPFERGAQVFKRQGWDECGVRVVRIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUX7</accession>
    <name>A0ABR3BUX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614917.1">
        <property type="nucleotide sequence ID" value="XM_066757448.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989802"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="17"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="239" mass="26074" checksum="CBCF97D46083B633" modified="2025-10-08" version="1">MAEPTETVNAGEEHDPHFEPVIRLTEQVEAKTFEEDEEPLFKMRAKLFRFHKDTTEWKERGTGDVRLLKHKETGKVRLVMRRDKTLKVCANHILSPDMKLSPNVGSDRSWVYNVAADYAEGEASAETLAIRFGNSENANLFKQAFEDAQAHNAGLSSAAPKEEQESAAAAEPEAAAESVAPEAEAKKEEAPAAEESKPEEPAAGAEAETKVADAPAAAEIKEEGTLEADEAAAEKKDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV95</accession>
    <name>A0ABR3BV95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614971.1">
        <property type="nucleotide sequence ID" value="XM_066757502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989856"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="258"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="368" mass="41630" checksum="CFBD5D244603E0CD" modified="2025-10-08" version="1">MPQYISAPSPYGSVSAEARRRYEERYAKKRAEEAAKARAEAEAANQPEQPQQPVQQQQSPAPPISLQPGYSQHHPNGYPQQHPGHPQQPQQVAGGPPHPHQNYARPPPQVVQNDPSVQPQQYHPVQSSAPRQQIQPQQQQSWNNPAPQGQGLALGHLSQSHPQQQPEQRSHQQQQQWKQAQKHSASPPAPVEDQDLQTMFLQFDSSRTGQLNAYDLQRLLAKDARMEAREDAVKMLMNIFDTDRSGSINFQEFEGLYRYIQDWHDIFRRFDRDNSGLIDRLELSNALQGFGFSLPPELVAKLVKRFTPPPTLGQTAASRPGISFDRFLLACVTVKHYTEAFRRLDPGNTGYITVAYNDYMDIVLDAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVB0</accession>
    <name>A0ABR3BVB0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_102560</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614574.1">
        <property type="nucleotide sequence ID" value="XM_066757105.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989417"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="525"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="937"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1016"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="254"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="396"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="837"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1016"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1026"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0250387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1207" mass="137202" checksum="9EB64CB152EADC6B" modified="2025-10-08" version="1">MPLQRLELYDFKSYRGKQVISFGDAPFVSVIGPNGAGKSNLMDAISFVLGVKSAQLRSTQLKDLIYRGRRAATREVGSETQTQTESGDDSNDARSAWVMAVYMDDAGKEWTFRRSVSMSGSSSYFLDGRSVAWKDYNAQLAKFNILVKAKNFLVFQGDVEGVASQDSKALARLIDRISGSLDLAPSYEAAKAAQEKATEASSMNYARKRSMLTEAKHFREQQEEIKQWERLNDSKDALTQRLILWRLYHLTNKISQSTQKVEEASDRLAEFRAASSEADSRLSDVKREQAKAQLNVKKREANLKKAEKAYEDKKPDLVAIDTQIAHSEKRASGAAAQEEKVKKDEKRQADTVKELEKGLEQITRNMAEAGERQRQRSQASGITLSEADLNEYRQLRASANLHAVQERQQLETLRREQKNLRDALASVEDQMQQAQRQREKLAGEVDSLGEREETMNEMNDERERIKGQLDHAQAERRRINMRETEINERLQDTYHKLLQAGADRRENERETRLKETLASLKRIFPGVHGRVVDLCRPVATKYDTAVMTVLGKNIDAVVVEHEKVAIDCIEYMRNQRTGQATFIPLDTIQVKPVPERLRNFARGARLAIDCIEYDPAVERAMQHACSSSLICDTMDIARYVCYERAQEVKAVTLDGTVIHKSGLITGGQGAGGGRKFDDKEVEGLNKLKETYLGQLQELYRSKPQDKGDEALLESLSRLDAESNIAKDDLHAIQVRLRGVREELTHAISTIERLAPDVEARSQSVASSEERSAALVETIEQADDEVFSAFCQRIGVSNIREYEDVQLRIAKEANEAMESFAAQQARVKHQIDFESSQLRNTRERIAHLRDLATKAENSVNELRSQREEIQAEIESLGAEIDRQRGKLNDANNVRDEVVRRVDDMRERSRKAQKTLDRAIKEIATWNDEISRLDKVPIEEPTKDEDGIMEEEEATQKPVEVDDYGLEPDFDILEEGDRENEDEEVGREFEAQISKMRNDLERLAPNMKAVERLDEVERELDDAEREAEETRRESKRAKDDFQAIKKKRCDLFNKAYNHMSEVIDKIYKDLTKSQNQVGGTAWFTLEEAEEPYLSGVNYSTMPPGKRFAEMEQLSGGEKTMAALALLFAIHSFHPAPFFVLDEVDAALDATNVQKLARYVRSQADRNVQFLIISLKSTLYEKADGLVGVYREQEQNSSMTLTLDLRKYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVD6</accession>
    <name>A0ABR3BVD6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615075.1">
        <property type="nucleotide sequence ID" value="XM_066756298.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988602"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF24">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046224046" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="4">
        <location>
            <begin position="258"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="313" mass="32254" checksum="816789EF48CD7339" modified="2025-10-08" version="1">MFAKAAVIALASASIVVAAPVNCARSKPSSYAEGYLEDYDTYHARYLALSCYTQHNTTFFDDCCHPLLANETLADNRASYCTPNSTDVASVNATMAEGAAATASATASADVEAESQYYNASSSDATASVTASSEATASETASSEATASETASALNNVAEIAQQSASATSSSEEQPTSASSSSSEESAASTSSSSASTSSSTTSSQVYTGGYATFYSQDGVAGACGTMHSDSDYVIAIDSNGWWQDYESNDNSPYCGKQITLTNTNNGKSVTATVADVCPTCETNNSLDLSIGAFNQIATEEEGMVPITWSFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVM4</accession>
    <name>A0ABR3BVM4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614679.1">
        <property type="nucleotide sequence ID" value="XM_066757210.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989526"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="183" mass="17662" checksum="1AFB47589F08B37D" modified="2025-10-08" version="1">MTCNCTPEKATSCCSTSEAQVNCTCQKGKCECEACPNSTKTSGSGACGCGVKEKASTCGCNGSGAACTCPPGQCACEDCPKKAKSVSTCGCGGSGAACSCPPGKCACDNCPNQAQEKVSSCDCNGSGAACTCPPGQCSCSGCPAQAKESPADQPTTCGCQGVGVACTCPPGQCACDGCPAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW15</accession>
    <name>A0ABR3BW15_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615302.1">
        <property type="nucleotide sequence ID" value="XM_066756525.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988832"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="723" mass="80431" checksum="E15C1DFDBF567955" modified="2025-10-08" version="1">MTSMIHSQSFDGGLTQGGLHTSPAASPGSGRPRSQSSLHIVPQSTYSPPLPTQSPHPISAYPVQAYRPYPQGESLQLRNPVNSTYPSTAPALPFYPAGPMSMYDSSGSQPMIRTISHAHPMNSATEQTVSSQYSSSPHSAHDHLADVPPITGGGQPNPWSHSAFHIQTEDGRSINPSMFGPGGDYSMSRSTSGASDSEHNTTRLLTPSLDYRSDRRSPHEVDLRKVIDSLGDKKHLSQVPFTPHFDLQSHSLGLGPHPQPEDMFFGNRGYSNAAFNLSSERGAREGTDLTGETEYERERAEQIMNNRKLLEDVGLGGHSLSFGSSHMSGTKGSNNLKKSKKVSTSVKKRIQLEGSVRASPRIRTMGRSISYANLDGGSGSDHDEYLSEEDPQEEEEFRPFKRSRGQMGFRQKSSSYTQSSNKAPSKPQLSLWGLLQVYPEIPHLFPLFYYTLNNDLTINSESVPLIGSIPSNCTPMVKAETLQAYFHRGRRVLSQIDAFTSRCDRKYDGLEIRWTELDYHTRIAIRDVRRKVVERCENYKYTRRDILDKHVGKGQWQPIEQGMIEWRVGMAANDPANDLANVTLTLPTPPPNAYVHQIRQQTTPSLYHDRVYRPFPQDRRAVPRTVSVIMAEPDEQAHFSYPPTANSAIEFYGYAPQQTPIPPMYGEDQVPMSVQMPDSVIAEPTGDILDETSKEANASCGESRRLKRAREDDQVEVSPENDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW65</accession>
    <name>A0ABR3BW65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614283.1">
        <property type="nucleotide sequence ID" value="XM_066757899.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990258"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="10521" checksum="B444E134FAC21000" modified="2025-10-08" version="1">MAAPGTIITSTPGAVPTGPAYQYSVKMTCTGCSGAVNRVLGKNITAPNAYHISLPKQLVLVWGPSLPPFETVTEKIAKTGKTINAKEVVEDASTLPPLEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWG1</accession>
    <name>A0ABR3BWG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615427.1">
        <property type="nucleotide sequence ID" value="XM_066756650.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988957"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045438686" description="Protein CPL1-like domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="3">
        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="199" mass="20989" checksum="E6D5C0070AB8D2DA" modified="2025-10-08" version="1">MPPIPPSVRRLVILFLIAAPLLSIVLPAAAAPADTDAPSKLQPRAPQPSRRMGATKRSKKMEPLKKKDYSSFLCPGGSVACPIPGDEVTPSSVEALEQSLNSLADWFKVGFECVELDTELNSCGGCLALGSGQDCALIENARTTGCESGSCQVYSCFDGYIVSPDRTSCVKKGSTTPATPVTAVNIEEFVADDQLPLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWI1</accession>
    <name>A0ABR3BWI1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="12">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_102123</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="12"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615451.1">
        <property type="nucleotide sequence ID" value="XM_066756674.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988981"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="390"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="591"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="14">
        <location>
            <begin position="1014"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="108"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="896"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="952"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1138"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="904"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="918"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="958"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1140"/>
            <end position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0252731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1209" mass="134740" checksum="DB862E6D45CE1847" modified="2025-10-08" version="1">MLSRVSSHLMTPTSNVGSPNPFNVKGKAPEASAIQPPGTNPRDNGKTTTQLQTMLVKYMEEKDQLKDQKFAIATGQDGMDDLDMDMVEEKIELVTKRILEIKTLLTARAQNPSSSTPPAPSRQSSFQPSETRQSPFQRAELKPPSLAVKNYPTPTTASSSKVKLATPDHWNSSRSNGVPSDESDMPVARGLLQRNRTYPSSTVAGSSRPTSRRPSPLHDVPEDLHDLDIAMAEKDFHGLDEEPVLVPPSTPPVASPPRIAVRTSTRQPQPLLAPEAIFQDTGHLPDEFHDIPFSEIFSSPISPTRNLPNAPLRVESSPPKPIDLPRPSAIAGPSRQPMETHSPIKETVPAVPQHRVIPLEITHPWSKEVNQKLRQVFKLPNFRKHQKEAIDETMAGKDVFVLMPTGGGKSLTYQLPAVCSSGKTRGVTFVVSPLISLINDQTRHLISRGIPAIAYTGDLTQKDKNVAHEELSKREPITKVVYVTPEMMSMGGHIKSILRGLLQKKQLARFVIDEAHCVSQWGHDFRADYLRLGELRRDYPGVPIMALTATAQNKVQEDIIRSLRIEGCVCLRQSFNRPNLHYEVRPKTSAVIQEIVAFVRTQEARASGIVYCNSRDNCENLAKKLREEHGLRAYHYHAGMTKENRRKMQEGWQDHKFEIMVATIAFGMGIDKPDVRYVIHHHLPRSLEGYYQETGRAGRDGNPSTCILYYTFKDGKKILGQIDQEKDLTRDQKERQKASMQEVLRYCNNKVDCRRSQVLAFFNETFDAANCNQGCDVCLGRDRNVFRTEDVTEDAVTVIKMVQAFSNIKITILNAAECFRGYKGNSGKRLDQNPYFGAGQSWERNEGERLIQTLVIEGALEEYCVESKAGWTNAYLRVGKEGYKYLNGTARLKMDFREASPRKSTTKSKQPSKRQSSKSKSQTTLGKTTSSNPIARKRSLQQIMAEEAEFDNSHWGDTDDEYHPEEDGDPIIVSADETEVDDGVPQKRRKSIEASKEKTPRTTRSKAKAATPDGGVESSVEQCFKALEKMRNQSTARNKTYPVLTDELLQMVAALMPANEKRLREIEGMTPQLIEAYSTKILGICIKFRPTNQNTLNTTATVVHKDVPRAAVVPAPVTLPRANSTTMHQIKQYAYEPSSAPKSPITSAVRRPSSTSSLKRQTLLFSTPSNVAGSGNTATPTAAKRQSNVGTVRPVLTARGGNVVRKDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWK4</accession>
    <name>A0ABR3BWK4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADH kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615488.1">
        <property type="nucleotide sequence ID" value="XM_066756711.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989018"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="45917" checksum="16049A0182B2E1F8" modified="2025-10-08" version="1">MQPQPIISRLSYVQYILLRFRMSSIFHFPAVYKLLRAPKRSPLYLRKSRRNIHYLRDLPVSPLSQLTSKPRLVSCEPSIAESSAMGAAKFPPAAHQLKKWTSEPTTLLLIQKKDDPRTTAAMGFILSHIQEHYPHLRLIVEAHTALDHPSFDNLIVASPGDEKLLPLHTSLVLTLGGDGTILHVSNLFSQGECPPVLSFSMGSLGFLLPFHISALSSALENTLKGPISVLNRMRLACKPIAANGDPLNRCTESVGEAGWQVMNEVALHRGRHTHLTVVDTYFDGQHLTEAVADGILLSTPTGSTAYSLSAGGPISHPETDAFLLTPVAPRSLSFRTVILPGRGEVKLEISPLARSPAELSIDGKEVCLLNAKESVVISRSPFPIPCVERSGSENGWVKDINSLLQFNVGFKNKSLMGHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWK6</accession>
    <name>A0ABR3BWK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="1">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_102153</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615481.1">
        <property type="nucleotide sequence ID" value="XM_066756704.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989011"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="111"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0252761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="259" mass="28072" checksum="8DD74A13C76908BE" modified="2025-10-08" version="1">MSSIAPEADTSLRRSSRVTKRIVIADNDEGHEGSQPAPKKSRASKPKKESAVVISDVVEIPVEAASSPPQAKESGGAAVSKSKKVPTGKKNEITPDEGNEEPEDEEDGEVLKMGDKLPSIKLNDEEGNTVDVSTLIGKKGVVFFLYPKADTPGCTNQACGYRDMYDEIAAFGYEVYGLSKDTPTAQQKWKTKKSLTYHLLSDPKSKLIKRLGAFVPPKNTKRSHFIFEKGTGNLIDVAIGVKPAEDPNNVLGFLTEKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWV3</accession>
    <name>A0ABR3BWV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614760.1">
        <property type="nucleotide sequence ID" value="XM_066757291.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989611"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF3">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046111843" description="DUF1748-domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8281" checksum="23F3D3CA14451929" modified="2025-10-08" version="1">MFGFGRLGHIVFDLIAISTILAGVKKSTGYSIQTSLFTDTAIRSFIDSYLSVGETVFGMLSGYAVNSRYFKRNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXJ6</accession>
    <name>A0ABR3BXJ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 6a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615564.1">
        <property type="nucleotide sequence ID" value="XM_066756787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989094"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000277">
        <property type="entry name" value="COX6A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13330" checksum="33C3A1C227A9DFDA" modified="2025-10-08" version="1">MFRLAARAVRPAARGFATSTAAGENEFVARRTAIRQHAAETTDLWRKISFYVCIPGIVVGALWTYKVESAHAEHLAHSDEDLSQRPVYPYMNVRVKPFPWGMQSLFFNPKVNIPAGPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXW6</accession>
    <name>A0ABR3BXW6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_102067</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615395.1">
        <property type="nucleotide sequence ID" value="XM_066756618.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988925"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="298"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="556"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0252675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="639" mass="72132" checksum="CA968BAAAA15D476" modified="2025-10-08" version="1">MPTITVDKAELYRRLEKEYSFEEFDELCFEFGIELDEDTTIQVEEARKRGLPTPPPQLKIEIPANRYDLLCIEGLARALRIFLEKDVPPSYKLDIPEKMQEVYVEASTSPLRPYFASAVLRLARPMNQLEYESFIDLQDKLHQNLCRMRKFVAIGTHDLDTIEGPFRYMCKDPKQIKFAPLNRDTENTAEELMTIYEADRHLSKYLHLIKDAPAYPIIYDSKDRVLSMPPIINSQRSKIVPGKTTNIFIDTTATDKTKLDIVINMVCTMFAEYCRVPFHIEPVRVHMPDGTSHITPPLEPRATTASSSYINAAIGLSLSRQEICKLLTRMSLSATPSPSSEDLLDVLVPCTRPDILHECDIMEDAAIAYGFNKLPREMPTTNTVAKAFPVNRLGDIIRKECAMAGWVEALPLILCSHDENFAWLNRPDPGHYAVQLANPKSLEYQVIRTSLLPGMLKTARENKALPLPMKIFEVSDVAVQDATEERQARNYRRLCAVYMDRKAGFEVAHGLLDRVMQILAVPFLEKKENEGNYGYYIASADDPTYLPGRAAHVFYRPKPGAHPSKPTPSTSSSNPSTSSSNPIQSFTSDLKVALHAEKGSSWERDINIGSLGILHPSVLVNFELIRPCSALEIDVEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ35</accession>
    <name>A0ABR3BZ35_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein SYM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615869.1">
        <property type="nucleotide sequence ID" value="XM_066755583.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987881"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0253648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="195" mass="22089" checksum="B9A91AB7DC6A2F9A" modified="2025-10-08" version="1">MASLMGKYAAFLTRRPVLGNMISSAVLFATGDVIAQQLIEKKGADHDLPRTARIVTWGGLIFAPTVNLWFRTLERIPIRSRWPATFTRVGLDQFGFAPVVLSGFFTAMTFMEGKDFNAAKIKWHESFVPTLQANWMLFIPFQMLNMLIPLQYRLLAVNAVNIPWNAFLSLQNAKGKKIEEKIEESHVAIPKKEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZA1</accession>
    <name>A0ABR3BZA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101084</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615929.1">
        <property type="nucleotide sequence ID" value="XM_066755643.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987942"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="544"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="811"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0253708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="856" mass="95615" checksum="988F31C0813BF139" modified="2025-10-08" version="1">MSSVLPLSPMRSPLDPSSKPRQMIILSIILAALLSRSTVVATPHAAVKEWYSERTRIRNERKRREAETPLNTPALEKKLVDLYIRDPSSDSRTLLVPHMGKISKVRITPTSPELYKQHLPLFPRMTGSEKLGVNKEFWRMLKAVLKVTFPSKRGKEVFLLLLHSFFLVSRTILSVMVARLDGKIVRDLVSANAAGFLRGLGWWFILAVPSTYTNAMIRYLERKLALAFRTNLTRYIHDLYLNYNLNYYKFGSGRGGHTAMEERGEKKRAEFGHSSEAAAGTADQFITTDVARFCDSLAALYGNLGKPALDLLIFTSQLSSSLGPLGTVGLFANYGLTAYILRKATPAFGRMAATTARLEGSYRAGLSRVGRDAEEIAFYNGGKRERGILDGMYRKLKEHVQAVNKARIPYGMIEDFVIKYLWSAAGYGLMSIPIFFPVAKTALGSMNQRVTHEVAERTEGYMSNRRLLLSLADAGGRLMYSGKDLAELSGYTSRVYALISTLHSLDNGIYPEHPRPSSLSPNEAFYDMANIQGQVSIGPNHVLLRGVPIVAPPEGSGAERGGEELLKSLDLRVEKGDHTLITGPNGVGKTSVARIIAQLWPVWKGLLERPRHGEGGIFFLPQRPYLSIGSLRDQVIYPHTYAEMKSRGRTDTELMTILEAVHLEYLPGREGGWETRKEWKDVLSGGEKQRMGMARLFYHRPQFAVLDECTSAVSSDVEGLMYEHAKALGITLVTISHRPSLLKYHNRHLRLGDPSLSRVPSSLSRAQSMYSLAAFQAPPHFDAPHHKLPTTPLASQGWQLTTLSSSSAEEKLELDKEIEALEMTLNEEVEKWGNRLQEINKELKYGESYVEESEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZH2</accession>
    <name>A0ABR3BZH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615996.1">
        <property type="nucleotide sequence ID" value="XM_066755710.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988009"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0253775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="415" mass="45605" checksum="825AAB96D3D7D5C6" modified="2025-10-08" version="1">MGENARSGHVDSSTLPPITTAVSDQPYEDTSTDHSSWSKQYPLGSSDRTTPGGTYQDNFVSSSRVAGTRPLIARQVRTPTRPSTAPSSRPSSWSLDVSRRPLYEEVLPPISALAEDLRHSSGHSWFPDPRNDMQRPTSSSSLRSRPHTSHSTDLSTAPTDYSIGRPTTTSSTTSWHLPLNSEYKGFAHGSQAAEDSETDPGGGPDDSKMPTPSAETQTTSPRPSLPGYFTERFSLYDSPQLPNSYHNSHYPSNVALIKDWDSFHSQDLNTKKEIPCIAPASAASTLVLVGKRHTPCNKLKDEHGQLGLFFFATDLGVRTEGRFCLRMKIMDLSLFLRAPNPGDSVPILAETVSQPIEVYSAKRFPGVIPTTKLTRLFAAQGIKLAVRESHKQKYRNKESVDMDVQDGIDEDEDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZL4</accession>
    <name>A0ABR3BZL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616041.1">
        <property type="nucleotide sequence ID" value="XM_066755755.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988055"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0253820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="630" mass="71053" checksum="CF20F565184AF91E" modified="2025-10-08" version="1">MPIRPSISAPRGLSQLKMPISVSKRAVTNKPLYASQSTIPHLPVPPLSSTLHKYLETLSPLLSQPDFSQSTSVVKAFAESDQAKVLQQRLKNRAQEKDSWLSEWWNETAYMGYRGRIIPNVSYFYIHKRGLGKGKSQEDRAAELVRATVEFKKLVDSELLEPEKVKGQPLCMASYRYLFNSARQPDRPSDFAKAYGPGNHHIVVLRNNRYFKVDTYGRGAKELAETFRKIKAIADRQPGPNVGVLTADNRDVWDSARKQLFSYSPTNKLTVETIDSAILLICLDSHPAPTTDDSRAWSFWAGGHDNQKDGRGFNRWFDKHEIIVDSEGESGFNGEHSMLDGTPTLRLNEFILASTDSNKIPLELDSSETSRRSATEPEELKFELDDKLKQIVVQSKREFEEEMEKQDLKMVTFGEYGKNLIKTYRVSPDAWTQLIFQLAFYRLFQRLPVTYESCQTRKFLLGRTEVIRSASNEGKAWVEAMVNENFPEGDEGRERLFRKAVERHVQYAVWAADAQGVDRHLFGLKKLIAPGEPTPEIFSDPAFARSSHWELSTSNLGSRYLDGWGYGEVVEDGFGLSYSIEDDALKWGITKKKGANGALASATELGHALGAAAREMASMMERAKTAKTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZN0</accession>
    <name>A0ABR3BZN0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616065.1">
        <property type="nucleotide sequence ID" value="XM_066755779.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988080"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0253844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="457" mass="51036" checksum="A336DF5714BFC850" modified="2025-10-08" version="1">MAPRASSRTHAKPYDRPAANSKSKGKGKAAAHDLGAPATHSQSSRKGKKAWRKNIDITHEEEALEKAREDERVTGGPMTTKSNNELFTVDVVGDAQVGAKAKRQHKPLRSLAILSERSAVPSLTSRVSKTAPQKKKPLLSSAEKERLKRIARKTQAFSDGTGLASADIKARGPVENDVWEEEQAFEVEGGFGEETIVKKKVKVPVTIARQRAAYLGSVDKAVETPEGGVSYNPSAESHAKLIDEAYKEELAAVEREKEEAALIEKFGSVVEARRHIERSEFAEGMLVGDGESDGEESSGDQDLPEKKASKRKTTAQRNRQARQRAIEEAARQEKEKRKLANSVSSLAAFKREVERKQKEQAEKERIAKLAKKEKEKRGKQEGEKVGKYRVQKKRVEVQLGDDLAESLRQVKPEGNLFKDRFLALQKRALVEPRVPQLPKKKALKIKEFEKHAWKRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C089</accession>
    <name>A0ABR3C089_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616055.1">
        <property type="nucleotide sequence ID" value="XM_066755769.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988070"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42476" checksum="9FE321C5EF909889" modified="2025-10-08" version="1">MAEQESLPAPPPPPLAPPRYVSAYSDDQVMYQERYVALQRLIHELEDENNLIAYRTLKEERRLGEHGTTFRGFAPEEGDVNGWFNNSSGRASRSGPVGDESAIESRINDSISERIKLGDDDRAEIQRKERERIEAERRELERLQAIERKRRLEQEEEEREYLGTGGRPSPVSATASIPVEGASDMQAAGTFDEDLELDRRRWLEFERELENRGEAPKHKPSEPLDVQTEQTGARPPDVARRHPSPGAPEGEIRRSWAKERDGYPERHEKRRREEDRGTIGAGVKRRRGSAMDDHVEQPFSRHSQQSPPIRTPLPTLGSPRPDQESPFSTRPAVHLSPVGLRHPVSPTTSLQEGRRRSLGASRGHNLSPGEEERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0G2</accession>
    <name>A0ABR3C0G2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616334.1">
        <property type="nucleotide sequence ID" value="XM_066756048.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988350"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046107945" description="Cytochrome b561 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="23"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="148"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0254113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="52065" checksum="B305DB40798623E0" modified="2025-10-08" version="1">MSRISIYVLSLLAYAHYAQAHGHHNVTEIDTSVPFDARIYIHMTLQTYVWAIAFPLGMVLGLSKSKYHVPLQSVNTMLSFIGIYFGHHHGGRQFPATVHGFMAKVLIWVMVIQACMGIFLKLHISEKKIRPWVVPFHSVLGKTFPVLGWTQMLFGVATALGFCRDGNLGQCAAHYIMGSAFIGYGAILVIMLNLGGKWLERRGCSQELLDSSVITVWGIVNTFTEHHGGPWTHKDMQHTMMGVLWWAGGMLGIFLSRGGRRSFIPSVIIIMTGWGMSAHEQAMMISSKIHALFGYALMSAGVLRIVEICFVLNDKPAPSNGAIRVFQHLPPYLLVLGGTLFMSATDEELRNADSLGIDHVTYALFDFSLSFLIYLVITFLVHLYSNSGRNALQKADNGEEIFDSAPAEEHGYAKVPAEQREQRGGDDDLHEDGPEAYEMADRDSSGESDAVKIGGEDEVDWMGRRGPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0R6</accession>
    <name>A0ABR3C0R6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616438.1">
        <property type="nucleotide sequence ID" value="XM_066756152.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988456"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0254217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="414" mass="45577" checksum="89530976728E48C1" modified="2025-10-08" version="1">MSQINNSQFGSGRRRKSLPSRLPEDVYNTSMRDLLELKPFSRDEEWDTDWSAALTRLWHRNFGEEVDYTYELVPNLTRCIRTRTLDPPNLPVYVAVGIVQELSLSHVLSAMMRTPYSETKVKAAVDKWVPIGETAEEQAEEDGDWVASSKLTGMSADGMQPSTSQVKSKTTTSSLRRGIRRPDLVIRVRCRHIGGSKSTSVPLTIEIKAFPLNDSGHPQSELKAGKAFVRGLSQTAMYTLAGCEMFRCRRGLFICGPAFCRVFVLDDTALAVEVASPPASLSALSVSSFFSSYNYSSMPHSFISPLASEQSVSPALFKLDPDYTINPLSCRLLESFIRGLVERTLSQTVGEASGCQTEKIDISSLSASHPDISFARWSPASNRLDSIGHARDSATISKVVNSDTGRKKKASSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C126</accession>
    <name>A0ABR3C126_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101465</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616307.1">
        <property type="nucleotide sequence ID" value="XM_066756021.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988323"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="778"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="780"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0254086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="826" mass="91753" checksum="2CBF8D0562051CB3" modified="2025-10-08" version="1">MFSFSQPKQSSSKPSQPSADNDISMDTQGQDQTPVQTLYLKPEAYPRGGKGKWKATGRTISAAVGPVGGEVAVWVTKKPSDDPNKPAKLTDANPTVSDEAIIFASINSLPQPLIQLYTESHLLFTSLQQIVADSARRRLSSVGFGVNGGAESWDTRGNFGTEGLLGPPDAETVINMRRLADFYVDQLGDLKTLPDIDAALRDRFIDAYNIFNIAEILYLPIDGKGEGLVGEELLDWVNEVDVAPDNQLGNEIMSTLNSWDHPSFWPYISRSILRGFHLPAASFLRSLSSHPYAPISKLAVLLAQHLTILPRSSEPKWRVDMDFLQAHKQWLGKFKSELAAQLGGKGEGKWFEGEWISWEEDFRCVVELMEGKMERVLEEAGDWREALGAWGVLVDVDMRRDHLPEVMSIITEKIPVDKSLPDHVAQAALCSADIIKALMSCYSLDTWLSAHLADLLDKLSLIPDDEEHFENSLRDFFLLEYAQVLQDNPNYKAFWRVICDYLGCAGEEGRGRLKEHLRRLDIPLERDVKGKSKESSASASVNEQEGLDATMDIENPTESQEEAIKLLDEVRSACVDFRLDDVWQGISQVLATRLISAGQYGMAATLALMARDGLALSRIADKVLEAFVTYGQDEYLSLVDTLPSTLLAEAPTALLHLQQSTSNPTDFPSHSAVSVFASRITFLSEFRDYLLFLSRGARDRAAGRVVSLLTSGIAPVGFWAVLLVESIGLLEDSEILFSSNETFELLRVLEEVYANAAFAEEDYLGQLVQYLRRTLNTPSAKEEGQSGKKDEKKVTMEDARRKMEEVRLAISRNLARAMVAGFNSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1A7</accession>
    <name>A0ABR3C1A7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616352.1">
        <property type="nucleotide sequence ID" value="XM_066756066.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988369"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0254131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="27573" checksum="8B497A2AD9A703CB" modified="2025-10-08" version="1">MVLRTPTAALRASLTPIRCMSSAARPSAVVKNSSSRQPSAPRVYPARKTFLWNLYNQVLTKSSLILIFDHANISAAEWSKLRRAIGSIKKPVVPYDPSLPKEEQLERAEIEQAQLMVVRSGVLTAASKACSSPIIPHLSGQRAVLTCSTLSPTYLNKIITVLSRTVKSIKRENSTIQPTLNLVAGLVEGGKVMNEKELEELGKVPELDTLRAQLVGLLEGQGRSLVGVLNQAAGGSLVRTLQGLENDLKEKEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1L9</accession>
    <name>A0ABR3C1L9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit TIM23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615892.1">
        <property type="nucleotide sequence ID" value="XM_066755606.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987905"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="30440" checksum="E12B83DA237296C5" modified="2025-10-08" version="1">MSYASVASHNIPFGEMPEPDQSLAENPPPAGEAIAPEVPLASEPPTTVELNPPPEPEPSVSDVAPKPLSPPPKSSVHLPESGAEWEKKKSKAGQETSKKAQEAKKGAKELKKEARVELNKAESKLAPYWEKTKDVVLRPGTLGGLLGVVNVGILGTIGYFAYTKRNQRWDNRIIGGTVAGTLALFGAEGYLAESYLSTPEGRAEADRAKAEGSKFYLQAKEVILRPKVAGGLVGALNVAVLGSVGYFSYKNWNRIWDPRIVLGVAAGLVGLSGAEGYLGKRYAGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C487</accession>
    <name>A0ABR3C487_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616566.1">
        <property type="nucleotide sequence ID" value="XM_066754665.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986944"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="12"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="310" mass="33695" checksum="A193D95EF9030960" modified="2025-10-08" version="1">MSAHGSAEAYEKYVQAGRLAAEAYYHAINLAKMKSDITLAELSEAGDKYIQDRSAGQINDGICHPTTAQLDYIICNNALKTGNPLKAEGSQLLKLQVGAHVDGYGVVVGGNFLLGDSLAAKKLAKAATEVAKLVLDTIKPGTTNGDLVKNVDEYMRRTSYRGVPGLLAHNHTQYDIQGPKEIDLFPSDDKPYQEGIIFETGEVYTVEVWITDAEDPAPQPAVDLDKTLHQIPPSKDISALSAPFKEAYRCITNKVGTFPFHSRVLNDSSLVKAADDLETAGVLAAYPAFQHSERSFKGSGTERRELCYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C494</accession>
    <name>A0ABR3C494_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_100252</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616725.1">
        <property type="nucleotide sequence ID" value="XM_066754824.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987110"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="11">
        <location>
            <begin position="37"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="12">
        <location>
            <begin position="184"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0255448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="434" mass="44451" checksum="4004AEF1046C1736" modified="2025-10-08" version="1">MYSLNRLPRSAALKNSANLLRRNASTASAGGVNVVGFENKGPAATSSLTVAIKAGSRYETTPGVAHVLKSFAYKATASASALRTAREAELYGGVLSAALTREHLLLSAEFLRGDEEHFLNVLASVLSSSQFYQHELNELVLPVVEAETISAQAIPSTIALDLAHSLAFRRGLGNSLYANKNYPVTIDDVKSFGDAAFAKSNIAVVGTGISTEVLAKAVGNAFGAGTSSASKLSTPQATYYGGETRVPLDIHAPATATPTMVIAFGTSSPASADLKVLKHLLGGETSVKWTPGASPLAQAADKIPGASAKAFLLPYSDAALFGVVLSAPTSAQTKALAQEVASIVKGAGEFKEEEVKRAIAKATFEDAASTETLPGFVAAAGPAALVGSVPEAQSFSGVSASSISKAAAELLKGKPTVVSIGNITVLPYADELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4E0</accession>
    <name>A0ABR3C4E0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose and ribitol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616771.1">
        <property type="nucleotide sequence ID" value="XM_066754870.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987156"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF26">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_4G05870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33001" checksum="B9FE8056065D8540" modified="2025-10-08" version="1">MSPPSSVPKEYRPGYLPPSITHQAQKDLPGKQRPLDPTPFNDVMADGSKYKPAGKLEGKNAVVTGGDSGIGRAVTILYALEGANVLFTYHPNEEADAKDTIDDIKKRVPQAKVEAVAVEIQTEQACFELAEKIKKWSGNELHVLANNAGTQNEVPNIEDLPSEQWRHVFDVNIHSMFYLIKSLIPIMPWGSSIINNASINPFIGHPKLLDYTATKGAIVGFSRALSNQIVGERGIRVNCVCPGPIWTPLIVATMGEESLKAFGPGTPIGRAGQPIEVATAFVFLASIDSSYFTAQCFHVNGGSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4K8</accession>
    <name>A0ABR3C4K8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616835.1">
        <property type="nucleotide sequence ID" value="XM_066754934.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987221"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="366" mass="39346" checksum="E346CD37342D0A4B" modified="2025-10-08" version="1">MFRQTSIRLASTAAPTRAVLRPKAHFRPPQSQYNGLRAVRRTYATDVPPPSQPSGGSGGSNGPMFLVLAAIVGLGAGGYYYLKPVRDVAAITHQSIDSIKDNASSLGDLAGYAKSMLPPGAFALYSHLSKQEGGINGFLSSLKDKDLKEVLEELKKAGGDDVKRIVEKVQKKVDEAKGNVEKVDWKGLAQDLKGELPEGSQRVVDMLIGRIPDKADIENLVKKAKSIGDEQLKQFEEAANKVWQKVEQAKKDKKSQADALLSGLKEAAPADVDSLIKQLKDVAKKAGLPADTTEAWLKSKVEDGKLDADAFAKQVEGKLKTAAKFIPGEPKDLVQQVEQVSPSLAKLVSQALQQAGVSDEKGNKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4Q0</accession>
    <name>A0ABR3C4Q0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616854.1">
        <property type="nucleotide sequence ID" value="XM_066754953.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987240"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="59"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="481" mass="51637" checksum="A99CEF3471DA1964" modified="2025-10-08" version="1">MSQDPETIKTFDINVDDNSSTNKNGGLSRVVTALETEQVQVVDGVWGTLDESAPNYRSLGWIRASVLMIKVQIGLGILAIPAVLDTLGLIPAIFVIFGVAVATTWADYVVGKFKKNHPEVYTLADVGYIMWGPVGREVFGAVYWIQLTAVAGAGLLSVSVALNAMSGHGACTIIFVVVAAIINILISSIQTLDRISWIGWIGLGGIMSSVITLAIAVSVQDRPSAAPATGDWSPDIILVGKPTFAAAIGALSNIIFSFAGAPNFFNIVAEMKRPQDYNKALMSCQTFVTATYLIIGCVVYHYCGQYIASPALGSAGVLMKKVCYGLAFPGLVVGCVLNTHLPAKYIFVRLMRNSKHLSANTIQHRVVWISCVVLNCTISFVIAEGIPIFNDLIGLIGALFATPNAIIFECVMYIWDIYHSADKYPSQRTWKQRSILAFNIVVLLLSMFAMVAGTYAAAVIIRDDVASNATTKPFSCGDNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C541</accession>
    <name>A0ABR3C541_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U2A'/phosphoprotein 32 family A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617024.1">
        <property type="nucleotide sequence ID" value="XM_066755123.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987412"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF23">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="7">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="370" mass="41891" checksum="0C590AAFF981C1E4" modified="2025-10-08" version="1">MDQQQASQNVSSDTQQSASQHVPSQVKPRARLGPTEVVQLPASDSEPDDDEGNSQQAEAEGDGDPDFLKDYPDDTEDLQLLHLRLKTPLLVPLNFPRFGNHLKRLCLRQNELTSPLPSEAFTNLAELGELDFYDNRLGPLVRDEELAGCPNISTLDLSFNNIRHAPSLPSLKNVDTLYLVQNKISRLEEGELDWCQETMKSLELGGNRIRVIENLDKLIHLEELWLGKNKIRVLENLSTFSSLRILSLQSNRITKLENLEGLVNLEELYLSHNGLQKIEGLHNNIKLTTLDVGNNFIKEIENLSHLSNLEEFWASNNQIASLHALESELRPLTNLCTIYLEGNPCQKEDMSNYRRKIMLSLPQVKQIDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C565</accession>
    <name>A0ABR3C565_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617038.1">
        <property type="nucleotide sequence ID" value="XM_066755137.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987426"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045948980" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="47686" checksum="74B7315D20FE570A" modified="2025-10-08" version="1">MHLSALSPLLLLLSLAHAHASTPPLAPAHPRRHHARALAVADANRPLLPRAGAPIDNGTLASIAAAEAAASSTAAASATAILSSVSSSVSAASSNALASSAVSSTSSGETSSSTLATSTVQSSSTAAVPSSTVSSEEMVPSTTSSDTESSTSISSTEVIPSTSSTTTSSSVVSSTSTAQLSSQLTSSPSSSSIASTAAHSTVVLVTTASRSATHSSTVSATSEADSASSKSSGLSKSALIAIIVVASVVGLAAIGWTAFRKWKLRPSNRFDSKMMPIDFSPQNGNMDDDFFEKTLQRTTSQSSANRQRQELVAQLDDDPNHVAGIPEHDFTAGAGVGAYGYQHDQYAGEQYEYDQYGGGYDNAYEHAYPPLPSHAMQHGYEYDQDDVLQQPATAVTTDSEGYAELQRGPSIGSGSGHGHGQAPLMSDTGVYPGELQFPVADTYGLGRPTHVTDGPYAQAANFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5N3</accession>
    <name>A0ABR3C5N3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I308_100749</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IND107</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617215.1">
        <property type="nucleotide sequence ID" value="XM_066755314.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987607"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028840">
        <property type="entry name" value="Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL0255938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="382" mass="42259" checksum="745E3ADC7C7837C2" modified="2025-10-08" version="1">MLYGARPRRPTVLTYTLILRSYSTPAQQKSAHPTTAYDRLRPVISTFRAPIDWAAAYGSGVLPQASYKPPAPGEAGPLTDLLIATPDAEVFHNINLAQNPGHYPVYARWMGGKGVGWVQEKWGAGVWYVTMVDMNGVNVKYGVISTPTLEKDLKEWTTFYLSGRLHKPVLTLLPPPLSLSSALRTNSHSALSLALLLLPTSFTEDALWEQIAGLSYSGDPRMSVPGAENPEKVKNIVKGEGAREGFRRVYGGLLRRLGISWEGEEKGDKKEWEWKGNGEETMVRPDGSEYLVSLTLSLPLSLRQSLTVHYPTLSSASSEHASWAPVVQDSRFRANLSEALRKIIHGPALRQSIKGLFTAGPVKSFWYSLAKVGKWFKGRKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C693</accession>
    <name>A0ABR3C693_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617133.1">
        <property type="nucleotide sequence ID" value="XM_066755232.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987523"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF40">
        <property type="entry name" value="YSC84 ACTIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="172"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="522" mass="56068" checksum="14CE15DBA7AA2FB2" modified="2025-10-08" version="1">MSNPPPPPPRRTYYPSASSLAPDPSAKTWKDKVKAKGSIWGKYAMDKSVKVSDNLGGKVNDLAERRFGTEAFWPVTGDFPKEMDKCARILRAFTVDGIITEEKEDKGASGSQKKKVIRKIPPAVIAKAKGLAIFTSMRSGIAPFGGAGGAGVVVAKLPDGTWSAPASISPNNLSTGFLLGVDVYDCVLVINTQKALDSFKTHKATIGAELAVAAGPYGAGAAVEAGLEKAPLFSYVRSRGMYAGVEIVGQVFVERYEENGAMYHWPDIKAGDILNGRVKVPVEAASLHKALKDAESGKAQKEKGNALDIVIPEGATELELNDGEVLKLPPTPDQTTGREQESDPETEKVLYPSRPGSHNPSFTSVDKISRGHSPASEGPTHESHFSSSKLTVPPPLPTRRPKRPSLEKNKSSTSNYSEEANNAAPTSSLETDVPPSYAEAYVNAVAGTEDPEERWESSLDDTKGEQMSAAEKKEWEQHLAEQKTQGGPLPESLQDGIVEGELSDRLQNQVLGYDEKDTDSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C7F7</accession>
    <name>A0ABR3C7F7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616706.1">
        <property type="nucleotide sequence ID" value="XM_066754805.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987091"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047522401" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16305" checksum="9CA509A0AA17935D" modified="2025-10-08" version="1">MPRSIIRIVPFLIAVFLALAVCLVGASEEKCLMACTNWSRVIEHCRWEYLNRFRNNQHDYTYNNGFVGCLCRGETAAGGIGNKTISASAGVCLNCPTTPGLVRKDLIALLQLCTVQAQNGTAADALLYRPQGFHTNITEPQPYEYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C844</accession>
    <name>A0ABR3C844_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_100444</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616916.1">
        <property type="nucleotide sequence ID" value="XM_066755015.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987302"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="14">
        <location>
            <begin position="72"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="15">
        <location>
            <begin position="588"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0255639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="792" mass="86026" checksum="C9C6942E11762DD6" modified="2025-10-08" version="1">MVSSRYLVRGANSLSRQSMIAKRSMATVQSSIGEKKVEMSNLEKGKYINYQRIEDNLQVVRSRLNRPLTLAEKIVYGHLDNPHEQDIERGVSYLKLRPDRVACQDATAQMAILQFMSAGLPQTAVPTSVHCDHLIQAQVGGKADLARAIDINKEVYDFLATACAKYGIGFWKPGSGIIHQIILENYAVPGLMMIGTDSHTPNAGGLGMVACGVGGADAVDVMADIPWELKAPKVIGVYLDGKMSGWTTPKDVILKVAGILTVKGGTGAIIEYHGPGVESLSCTGMATICNMGAEIGATTSLFPFNHRMSSYLKATNRPAIAQYAEEFNHNLQPDQGCEYDQRIEINLSELEPHINGPFTPDLATPLSKFADEVKRHSWPQELKVGLIGSCTNSSYEDMSRSAHIAREAASHGLTAKSKFTITPGSEQVRATIARDGMVDDFEKVGGVVLANACGPCIGQWDRRDVKKGEANSIITSYNRNFTGRNDANPATHAFVASPDLVTAMIFAGDLTFNPMTDSLKGADGKEFRFSDPSGYELPAKGYDPGENTFQAPPADGTTVSVAVNPSSDRLQLLKPFKPWDGKDIIEAPVLIKAKGKCTTDHISAGGPWLKYRGHLENISQNCLIGAINADNGEANKVLNQETGEYGPVPTVGAYYRDHNIPWVVVGDENYGEGSSREHAALEPRFLGGRAVICRSFARIHETNLKKQGMLPLWFKNPADYDKISGTDKISILDLQNFKPGQDIKVEITHKDGSKEQFLTTSSINEGQWGWFKAGSALNMMASAAKARAEKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C8H7</accession>
    <name>A0ABR3C8H7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Charged multivesicular body protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617051.1">
        <property type="nucleotide sequence ID" value="XM_066755150.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987439"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24710" checksum="AF2FAF56EB92F2A9" modified="2025-10-08" version="1">MGIWQNTLVRLGVAQAGPKITTQDRAILDLKLQRDKLKQYQKRLQVILDREHEIAKEALKAGNKNRALTALRQRKYQEQLLSKTDSQLVTLQELVSTIEFTQIQNTVLHGLEMGSHVLGELQKEMSLERVDRLMDQTREGVEYQREIDEALMSKMSPEEEEAVQEELERLQSEALPNVPEVSAPVALPDVPVEEPSVPEPVERNGSEVVQEDRVALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHK6</accession>
    <name>A0ABR3BHK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_106743</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610703.1">
        <property type="nucleotide sequence ID" value="XM_066761163.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993596"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0240195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="367" mass="39776" checksum="EEFD7A48872B3C5F" modified="2025-10-08" version="1">MQGYSNGYTGLPPSLNPNSVVGQYAPPQQAQLSVQSRSGSVPSSQSHEAIKVQPLLCSGHTRPVTHLQFSNVLDDGTYLLISACKDGNPMLRSWLGDWIGTFIGHKGAVWSSKISLDTSRAVTGSADFTAKIWDTYTGEALHTFSHNHIVRTVALNPQQTPQYLLTGGHEKKIRLFDLGRPDAEPLVLGTNPDGLSCEGIVKSLVWDEGQNGTMGVSAAEDGKVRWWDLRTLSQVASLDLGEPISSMELAHGGGTLSVTAGKNVHFLDILRQHPPVTIPLPHPVTSASLHPYLRDRFVAGSTSDPWVRVYDLDSGKEREVYKGHHGPVLCASYSPDGEVYASGSEDGTIRLWQTNPGKAYGLWQTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHQ8</accession>
    <name>A0ABR3BHQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610744.1">
        <property type="nucleotide sequence ID" value="XM_066761204.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993638"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="45709" checksum="F7B578C1CD8951A0" modified="2025-10-08" version="1">MSGSKEVENLSYVDIQHDAVDVFDDVEQSVVMKEDIWISGYHHGETSVHGKAMVEFEDGGSINITAQNGVKVERITKTDFMVDVPTLGVSNRPVHFPKHVLHPPYKKTSDVDSPLQINALAVNPKTPHIVVGGPNGYCMILPTGVMASPEKEGVKLKGHVGDVRAVKWFPSGEVILTASADLTIRVFGINGVNPRTFKGHSRAITSLAILGVGKTVLSAAKDGSIRLWDVGSGEQVKQWLTGGEKGSLVIENLILVEESTALEALGLQGQERAMLVQDQLGVWVQPWDGQGWLVEADKQIASLAYQKRTGTIAIGYSSGIVEIRDLSSLAPGTTGKRKKIRRNESPVYCLTFGLDVEDGEMDLYLGTAAGLPCRLGVKCVADGYQVVVKDELAGWDAVGIECMEVARDGMWCGGGEGGLRRYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIB8</accession>
    <name>A0ABR3BIB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_106692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610939.1">
        <property type="nucleotide sequence ID" value="XM_066761114.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993547"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="532"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0240440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="557" mass="60092" checksum="ED5EB5142FC02164" modified="2025-10-08" version="1">MQTKHQAFFSRNPPGLNPNRLSLFKGRPLGTFQRGTISMPSSALRGVQSMGNFGNMGSVLDAPHSAKGVFEFHKGVNESLSPLFPQQNAAADTNTSSQDPQSWLPFSNSTSPQLDALHSQPPQGPSLFFDSGTPMVPTLTTTVTNSTSHLHPKNMTLSSASSLRLDGYSSDEYDGLKKETLDNGKQRKKKRAQVRLACTHCQKACKKCSDSRPCERCDKYGLPDCVDTTRKPRKTGIKRGPYKRRASKSARNTGSDVYLPPIHSQPQSRFKFNSLQPFQHTCSQIPNVHCPASTEESGIPSYPPGPRLKSISTEAASTSLLTQALNVALTEPRWVDGRRVSLSDPSLGNLEDIGRNGEPKFSPMYPRTPVGGFPMALGTAGDPFSRAVSPIRPFGMGINKGESGGHERGIGENGRKYGGPIDIDLPQVPSRDQSSLFITITNPFLPNTNTSGNVSGTQNDEGYSPNPIYTPSTLHSPAPLSPQSQLQPHLDACAPPGTVSPMYIPSKTRKPSLWTLVAADSWNGGLAPFSPPLDLSQSQSQPQPQLQFSGMGGGLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIC2</accession>
    <name>A0ABR3BIC2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610941.1">
        <property type="nucleotide sequence ID" value="XM_066761116.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993549"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="89" mass="10434" checksum="C85131F261640C09" modified="2025-10-08" version="1">MPDYLSVPTCVEWRRMMPSIPHLIRAARPYGCELNLHSHALLSSSHIKLHPPKWYVKLLPSSPFFRPILLRENTKKNESETSLQREQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIN4</accession>
    <name>A0ABR3BIN4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611021.1">
        <property type="nucleotide sequence ID" value="XM_066760749.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993171"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="7">
        <location>
            <begin position="263"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="552" mass="60937" checksum="BEDF045364EEFBE5" modified="2025-10-08" version="1">MLRLCRTCRVGAYAPRRTLATAAAAGPDLPPGRPQAQLQRPDRAGRERDRFRAPNNKLRLADILQTLAKYKAENRSPTPVAYINIIEAASEFALGHRVDGDQGDGLGFQVALAAWEDAKRGGVELGQEGIDAMMNFAVIYPHLLSSLLLYTKNRRLTTYNAMARVAASSFEVEQMIYLLEEMSQQGFVPNTTTLKHTIRQACEWGYPRLALQIAQKAEEESSFGFRLDQSAWVQILIASADNHYLHGVETAWERVKSSYTPDEGLILSMLNAAGRWGRPDFSSTILELLPGPPQEHHLGPLLEAFCNAGQVPNAFHVLSTIRSTGLTPTLSSIQPIVNVLKSAEVIDQAYYTLEDMHKSGQAVDITALNAVIAASSAIGDLQRARATQSAIPEFGVTPTIDTYNCVLQCCVVASHRALGDTLLSEMAAQDIQPNATTYDYLINLCLTQPAYEDAFYYLEKMKADGFKPGYSVYASLVKKCVKMGDSRWRLVVDEMKDVGHKVEYELQGFINNGGKQRGGSRSREVAGQRRANDEMVGSKRRSWIKQATEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIR3</accession>
    <name>A0ABR3BIR3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611077.1">
        <property type="nucleotide sequence ID" value="XM_066760805.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993230"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="568" mass="61242" checksum="A7DDCB47A0B13FC3" modified="2025-10-08" version="1">MTSTLASNFLINPSPPIPASSSPNSAFQINQVPYSTSVSPPLQLPGGRLTTPLAPPPPPPLHLSSHRHVPGPERQIRYAGADHTLGPTFSEEEDGDDSAFIAAKMAALGLDPNGVPYSQNGYSGSHSTRAPRAKRSRTPTVPRSHQQGDQQYTQQQALLSLLAHQSSSAQVREALALLELQQAQQAATDRHYHTQMTAQHHARLAAQRQAEKQAEYEKQLYVQQQMQQKLLEQLAIQREATKRQFQQQQEEQYMLQQRGLQQLHLQQQLAALQTDSYVAQAQAQRQRSALRAQMQANLQARSERAAQANWALGVNEADLKSRFESAMPIKGSVHEDHSRFETGVYGTHGASTSSSSSGSSTSPSWPSAQLSSPTKSTSGIAEVPVSSKTAPGGRFAQARLALAASGTSSYGTLTATLSKRSSSEDQTTFTVTEVRTPPDEMSRTTPASPTTQLARRSIGFSLGRPTASVTLAEGKITRDAADAASARTFDLSFGGPHCSGNDDSRSSSQPVGLSMKKISVTRQPSGPPGDVKDLGDRNFQARIRKQVGLNLGMLNRRTESPAEIASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIU2</accession>
    <name>A0ABR3BIU2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="15" type="ORF">I308_106403</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611104.1">
        <property type="nucleotide sequence ID" value="XM_066760832.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993258"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="12">
        <location>
            <begin position="8"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="11">
        <location>
            <begin position="281"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="538"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="14">
        <location>
            <begin position="776"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1042"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="640"/>
            <end position="642"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="647"/>
            <end position="653"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="740"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0240605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1070" mass="118314" checksum="4274E81E7E3032C1" modified="2025-10-08" version="1">MRKQLDPRIPALINNGVKANHRSFFVMVGDKGRDQVVNLHFLLSQARVSSRPNVLWCYKKDLGFTTHRKKREAKIKRDVKRGIRDANEQDPFELFVTVTDIRYTYYKDSAKILGQTFGMLVLQDYEAITPNLLARTIETVEGGGIVVLLLKTMSSLKQLYAMAMDVHARYRTDAHQFVQPRFNERFILSLGSNPDCLVLDDELNVLPLSKGKDIQIGKAGEEDDRGRKRKAEELKEMKENLEDVDIVGSLAKLAKTVDQAKAILTFVEAISEKNLSSTVALTAGRGRGKSAALGLAIGAALAHDYSNIFVTSPDPENLKTLFEFVFKALDALGYEEHIDYDVVQSTNPDFKKAIVRVNIFRGHRQTIQYISPEDSHVLGQAELVIIDEAAAIPLPLVRKLIGPYLVFMASTINGYEGTGRSLSIKLIQQLREQTRPSITKDSENTAANAAGSSSKAAAAGRSGAGLVRSLREIKLDEPIRYSPGDNVEKWLNNLLCLDATIVSKSIQGCPHPSKCELYYVNRDTLFSYHPASEVFLQRMMALYVASHYKNSPNDLQMLSDAPAHHLFVLLPPINENDNTLPDPLVVLQVALEGNISREAILKEMAQSGMRSSGDMIPWIISTQFQDNDFATLSGARVVRIATHPDYARMGYGSRAMEALESFYNGTLYNFDDVPVDMGESFADAAKVGPNANLQNDTIAIRDPSHMPPLLQRLSERKPETLDYLGVSFGLTRDLLKFWKKGGFTPLYASQKENALTGEHTFVMLKVLASAGGGGEWLGAFAQDFRHRFMNLLSYEAFKKFDASVALSILESTIPRNSPSPAPRLLTNTELSSLLTPFDIKRLESYADSMLDYHVVLDLVPTIASLFFGKKLETGLPPAQQAILLALGLQRKNVEALETELGITSTQTLALFGKLLRKMTKSLEDIQKASIASELPAEPTLAGLSANGSNKFVALQQTIEQDLADSAVQLNGEDDDATKKEQRELLDTLNMEEFAIGQGGDWTEAEKQVERLASGKGSARLSSTVSVKVDRLVDDDKAKVVKGEYAGAKDAKKKRRESGGEKGGKKKMRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ94</accession>
    <name>A0ABR3BJ94_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611254.1">
        <property type="nucleotide sequence ID" value="XM_066760493.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992901"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046302565" evidence="6">
        <location>
            <begin position="22"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0241872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="266" mass="29200" checksum="2C32F2F48F0B6D2C" modified="2025-10-08" version="1">MKLNLTISLLALAILSAAASAVQLPVGLNLDKDPNGKKVNVSLYVMSKCPDARLCENIFGQVLRTESILPKISLSLHYIGTLNSSLPLGVDVKHGFTEAYGNAHQLCLYRHLPLTEFWAAVECMNFPSSFPKDIGKVGFTKQCAETVGVDWWGSGVGKCVEGKRGKGKGKKDKEDYRVGKEGRKLLVENIRETEETGITTSCTIEIDSTLVSEGKRTCVVDGGVWKGCDDGHTAADFVRVIDAEWKNLKKDTSFNDEAFEDDYMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJE6</accession>
    <name>A0ABR3BJE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">transketolase</fullName>
            <ecNumber evidence="5">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_106091</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611299.1">
        <property type="nucleotide sequence ID" value="XM_066760538.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992946"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF6">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="385"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0241917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="724" mass="79222" checksum="3C4C9EAC2995749C" modified="2025-10-08" version="1">MSPVAVLQHGDSASHGAELSKNPHVKSTDVGTEKLVINTIRCLAADLCQQYKGGHPGTVMGAAAIATALWKYSMRYNPSNPDWINRDRFVLSAGHACLLQYIMLHLSGYSSWTLDQIKKYHAPTMDGIAAGHPEIEFPGVELTTGLLGQGIANAVGLAMANKNMAATYNRDGFPIIQNKVWCFTGDGCLQEGVGQEALSMAGHWGLDNMILVYDNNSVTVDGNIDICFTDDTNAKLKSLGWHVLEVEDGSNDLAAIVDAFEQAQKLTGKPVFINIKTIIGIGSINQNSGKVHGAALGEDDVAQVKTALGFDPKQKFFVPDAVYDYFKETKTRGAQYEQGWNDLFKRYKESFPVEAAEFQRRLDGKLEEGWENKFPSKDALPKDPKATRQSSGIALRSIVPEDKTFMVGSADLCESTFVNWDGMVEFQNPKSGYGDYSGRQIRYGIREHAMVAAANGLAAWHKGAIVPIMSSYFIFWLYAAPSLRMAALMKLRFIAVATHDSIGVGEDGPTHQPIAFPLFLRTLPNFNYIRPADAEEVIGAWTLSLRDADHPSLLSLTRQPVPLLAGTDRNKVQYGGYVVYGDENRIPDITLIATGSEVARAVDTAELLKGKYSVRVVSMPHTGRFDAQPLEYRRSVIPSTKSLVVSIEPYASFGWAKYAHAGAHMTGFGHSAPYSVLFEHFGFGPKNLAEKIGTWAESKRNGDGWNLPGVGEFEELLANNANGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJP6</accession>
    <name>A0ABR3BJP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation protein SDO1/SBDS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611391.1">
        <property type="nucleotide sequence ID" value="XM_066760630.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993038"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="135" mass="14841" checksum="566245687018DF44" modified="2025-10-08" version="1">MSSVAVAVVYKPNEYADEYMVFVDDVADYERWKDGAKDIALSRFIGQFSIYKSATSGHTGSLGEISKQEIENVFFGDEKNVKDKSVEAAIMIILQNGKMHKSDFKHSYKLNMNPSRGAGDTRATGASGAAMGFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJP7</accession>
    <name>A0ABR3BJP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_106285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610990.1">
        <property type="nucleotide sequence ID" value="XM_066760718.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993140"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="283"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0240491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="636" mass="70676" checksum="A640FB415E74A335" modified="2025-10-08" version="1">MSSTSPRSTSSKRKTLPNLSDSEGESAFSEVLTRQARRKQKKVTLAHIRDLILFIVADGQKPQWIQVNNKSYISHTVLLFVPGLLPTHLGLSSDTTSVSMPFAISSISADEDILDREGEPIQKVPAIASLFTYGCPTRAPGDKLRMHSAINQLLMCPIPEHVKRKREAEKEKNHHHTAAQVDSYSPLLYLLTPNQMIDNDYNIPSYLPHVDRRVVPGLDRSMIPDQSNFLLSSLSEVEDIKVRDEPERLTGIDSTRSTKGNTREGGWVETSPAEGPPKDGIYPILAIDCEMVVSKDGDELARISVIDFNNGKNVFDELVLPPGEILDYRTQWSGITAERLSSTTHTISSIQDLLLSGPSPLITPHTILLGHSLECDLNVLRIRHPLCIDTALIYKHPRGPPFKPGLKWLAQKWLQRDIQVSENGHDSEEDALACVDLLKMKLANGPDFGDSINNMEPIVERIGRYQDNSPESRKTSAYCDYGDPRWLYGAKATTAVRCTSDDDVVNAVVKNAQSHTFVFGRMMELSEAQGWNDGGASLSSNSTVSLDPVLQRFNNRLTTLHSSLPPSTALIIVTGHSDPLPMVKLTKKRQRWERSVKIGGIEGLSGDDRWMAEDDRDLEKAVEDAKEGMAFFRVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK06</accession>
    <name>A0ABR3BK06_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alkylated DNA repair protein AlkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106118</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611326.1">
        <property type="nucleotide sequence ID" value="XM_066760565.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992973"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="301"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0241944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="427" mass="47857" checksum="F5198324B05C2E25" modified="2025-10-08" version="1">MSMENTSSTLTAFRQAEKHFKNRANKDIYPSLRQWQDRLIDLSRPDSQEEDEIWAAGWWSPDHDIVPVATNGRRRKGIVKKNKGERPELDTASHKSLPLHGGKTGYIVAPGCILIPGYLTAKQQLSFLYDSLVQYTLPPNPLSLSTHYDLPPDLFSLFVSDPEATVLPKHMTGAVNPEVLASASQPKSRKLNDTEPASVIGYEEIIARNKAWTGDVPSDKLEAKEVRKLWKEIRWANLGWVYQWSTKSYDFTPETPIAFPAPLAELCSEAVASVPWENVFSSESDPDAATYGWQSWPRDYKPDTGIVNFYQLNDTLMAHVDRAELDPARPLVSVSLGHAAILLLGSDSRDEVPRPIILRSGDMLIMSGKGRQAYHGVPRILEGSLPSHFLVQESDSENMKAAKNWISTARININARQVFPPGFERLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK41</accession>
    <name>A0ABR3BK41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105789</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611542.1">
        <property type="nucleotide sequence ID" value="XM_066760238.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992644"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045398580" description="P/Homo B domain-containing protein" evidence="10">
        <location>
            <begin position="22"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="747"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="11">
        <location>
            <begin position="505"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="494"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="657"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="807"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="860"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="882"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="895"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0242160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="916" mass="99913" checksum="4F504DCC2A2807B7" modified="2025-10-08" version="1">MRPLFPLWGILLGLIVPPSLALQTPQPRAYDTHTYYALELDPSTSSAVASQISELLGVELVERIGELDGHFLVRTEGWTPEHAVIAKRSASHDPILKRWEALPSGLGKKSLTPLSLKQRAKRHKSYSSRSQYSRDDRAELIYAQNELHLSDPMLDQQWHLINTQMKDIELNVTGLWGRGITGEGVHVVIIDDGLDVESKDLKDNFFAEGSYDFNDHTELPIPRLKDDQHGTRCAGEIAAVPNDVCGVGVAYGSKIAGVRILSAPISDADEAAALNYAYQLNDIYSCSWGPPDDGRSMEAPDGLILKAMVNGVQKGRDGKGSVFVFAAGNGGGSDDQCNFDGYTNSIFSVTVGAVDRKGLHPYYSEMCAAMMVVAPSSGSGDHIHTTDVGEDKCAHNHGGTSAAAPLAAGVFALALSVRPDLTWRDIQHLAVRHAVFFNPDDPTWELTAAGRDFSYKYGYGKLDAGLFVEAAEKWQVVKPQTWYDSPAVYLPTTSPADVIKRQDETADGTPSTDEEASNPAPVVEPTGSFITEDGIISTYEVTQSMLDDANFERLEHVTVRVWIDHQRRGDVEVELTSPNGIISVLCRQRRFDDADSGFPGWKFMSLKHWDENPVGKWTIKVRDQINPDKTGRFVAWSLQLWGESVDPALAKLWAPAEEGQPDEEQTGSDSSATATQKPKPTELLPGDHGEASGEANQPGLVSPTAQPQPTYTTGNDGDIAEPTSPTDADADEGFFSGISNLASSSTWLVAAGAIIILSGTAIIAFFVFRARRQKRNRFGLSNNGQGARGAYQPVDDVQMSLLERGRRKFGKSKNESQGTKDLYDAFGDGPSDEEEDDLDERTALRYHDGFLEDNEPNEEEGSKTEYRDEPEPEILRDEEEAAGTKDKDKGKGPSEGESGSGSSSSWQDAAEEEARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKA9</accession>
    <name>A0ABR3BKA9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105838</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611591.1">
        <property type="nucleotide sequence ID" value="XM_066760287.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992693"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0242209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="381" mass="43123" checksum="11DDD05FB2A67452" modified="2025-10-08" version="1">MTTRDPSHSPSYTIPTKYILTKAHLAAFQRSKTYSEIFGFIDELNEDIVGKKLTEAGEGSERTRPLIGILNSVHEIAESTPPVDNKLSRFGNPAFKTFYDKVGDASHELHTRIPGLPKEAIQEVEVYFRESWGNKQRVDYGSGMELNFLSWLLCLAKLGLVTKEDYPFLVLGVFWRYIEVMRYIQSTYWLEPAGSHGVWGLDDYHFLPFLWGSGQLRNHKYLRPKVIHDPEVLDEFSKDYMYLSCISFINSIKTASLRWHSPMLDDISAVKTWEKVNEGMKKMFVAEVLGKLPVMQHALFGSLLPFPTPEEDPELKRALEEEGQPAMDAHGHIHDPSEKGWSMDCCGIPVPSAFAAAQNANTLKGVSTLSNRPGIKPIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKP2</accession>
    <name>A0ABR3BKP2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611735.1">
        <property type="nucleotide sequence ID" value="XM_066760431.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992837"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22700" checksum="752E6349F1982AE7" modified="2025-10-08" version="1">MPPRKGSSTTAKSSGKTKRIAGLSQPTLGFQSQRKHSGTISKSKPSLQRQTSAISEVNTEQEEQGDGDIELLARPHANDQTAHKGKDKTTESNVLPEQTTKDGELRQLKVKSKEWAQALKAAKEAMGNLEPIHAGPDTHNDVHHILRVFDMTAKYGPCVGISRLDRWKRAQKLGLEPPEEICMILTTQQGQEDPSYRENVLNGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLE3</accession>
    <name>A0ABR3BLE3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidyl-prolyl isomerase CWC27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611982.1">
        <property type="nucleotide sequence ID" value="XM_066760036.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992437"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="490" mass="55366" checksum="4A923912980B7254" modified="2025-10-08" version="1">MSNLYATEPATNAKVIIDTTAGEIEVELWGKECPKAVRNFLALIMEGYYDGVIFHRVVPGFIIQSGDPTGTGMGGESFYGEPFQDEIHGRLKFNRRGLLGMANNGSRNSNTSQFFITLDAAPELTNKHTMFGKVVGNTIFNVLNIGNLDTDKEEKPLIPPKIRRIHIIENPFDDIVPRITAEEKKAQQKAKLEAKKDMEQRERRAKAKKNTGLLSFGDSEEIPEESVTIKKKSMTRQDLVDPSEVQGSESRTSKMTETFVNIPPSLKDLGKSRESEAREEKKAVDLKNIRAKHEREKTGGSAARQAEIKRMEEDLRRLKKRSGSLSDTDSDSSSRARRKGPSYLEQELAKYASNRGRAAMKAGNKRSRRDEEEDVLAEMRKFSSRVMQAEDEPEEEQAEEIEEGETKEGTGIGAAMAEEEGGIEVDDDIGWLKHKLKFHVDEKELTRRAEDEYAVIDPRAKARDLQEKPDKKKWKGNPNRRTVRDVARNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLL1</accession>
    <name>A0ABR3BLL1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612041.1">
        <property type="nucleotide sequence ID" value="XM_066760095.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992498"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="819" mass="91704" checksum="0676DDA107AF6A91" modified="2025-10-08" version="1">MSSNPPILSIPHQLSSPASHIAHYLSSIRPHAAGHARAGINDFQRVLEAGSSKTSSSKSSEGREPIIFGKQQDDDDRGSDWVATRQEIIQRTGDARKAIKKAQVVIHTDGSPLKAIQTNTFKMPLAAVKKINDSHSKPEEKLRQPTKDNVNGAYAAEMDSAQRRLERKLRRRERAAIGKPKLPTPLRPTSKSKRKIKAPSIDGSKEESEGSHVSDRRKKKGKKYRALPEIVKSYQAKNVQAPGGRITARPVQRQGFLGHGKASLPIRLPSEKARMAPPQPFSEDRFLGSHGVSLDPMMGEDQEIWNQWRIRAPQPGPLPRSHPRGKQPQQQSEASWQLGSSQFQHSSIPASSFTSIMPSNHRHEAASASQFSNSRLPPPGHTNSPSWHTETTERPSYENQQPSSLDKKIIDIQSKDKVTSGQAIISIQSHPKLNPTSNVESEPAEFVGSVSNTWPIIKGPNDLACTAGAPWKENRPSFGRPIHAEDLSFGKTPIHSGDNGQAIGYFQRSQNNSLPASWSNRVAPDIERSHNPPQFQSSFTSISESMGEFMEVGRAPTENEFQSYSDTLKQHIELMKGQQNYQVQRPCDTTFHADGPSVLAMPQIPVLLPFQMPRYNQFHSSRQKDYPYQDDGDLDQGSLRPHLFSQQKINSEQIHAPFGAYQRRNQQILLSKCDNAYHSNQANITPLHELQPQAMSFYDPSEPMYQETMADDPRLFLAPFDGAFDSIEPQQHLRCLGSSTNIRSNRPLLVPPTVNDAVDLYGDPLNPVNDQHLSFDQFDQSHFVEQGMWQERPGGRVEEQVGMTEEDWHGLWGQRAYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLR3</accession>
    <name>A0ABR3BLR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104991</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612098.1">
        <property type="nucleotide sequence ID" value="XM_066759451.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991847"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="60"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="499" mass="54218" checksum="0C435B33CF3777FB" modified="2025-10-08" version="1">MPLETPLSASLTQEGKSTAVDQQDASNIVDSASDEWVVKWDGVDDPECPLNITLFQKWAITTIVSVSAAYLTACSSLASFTYPAMEVEFGVSCLVCTLSVSLFVLGMAIGPLLTGPLSEFTGRRRVLLYGILCNFPNNISVHLVFRFLTGFAGAAFGAVSGGVISDVFPNEKVGTPMIIFTTVMLMGPVIGAILSAAINVNANWRWTYITVLIWAFIMTMLVYFLVPETSAAQLLTDKAKRRRKDTGDGKWRSPTERENRSALLAFKRSLGTPFVLLSTQMMVLFLDLWSSLILGILYLSFSGVPYIFTMQYHFTTLQSGLAFIGIGLGELFAIVVQLLLGRHYRQIALFHGGTAPPEVRLVPGMYGALLAPLGLLLLGTTSLPKIPWIIPILGSTFFGCGLVLALSSTFTYLIDAYRPVAASALSSNNFLRAVFACAFPLFGHQFYNRLGVTAGTCVLAGLLFAAAPLPFIFYKIGPRIRARSPYGNKVETLSLNNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLZ9</accession>
    <name>A0ABR3BLZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610968.1">
        <property type="nucleotide sequence ID" value="XM_066760696.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993118"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="73" mass="8242" checksum="88F2353269E79F16" modified="2025-10-08" version="1">MKIEMLSGALQLLELHDVTTYKAIKSGAIFGQYIPSLNFRILNFAWLSFALFVSVGEVLVKRGNVSRFISDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM18</accession>
    <name>A0ABR3BM18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sec39 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611649.1">
        <property type="nucleotide sequence ID" value="XM_066760345.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992751"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="6">
        <location>
            <begin position="224"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="846"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0242267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1079" mass="117282" checksum="EF1A96AE9A52E63E" modified="2025-10-08" version="1">MTVQMTEEELLETLPIPVTSASFIQTLITLPDSEAIVLCFKLLISGTVEDVILAKDVIGQGLEKGLVYFADVLALPEEVTEEELEKVVAVREETLRAYLGLEEMRRRIDTWEVISPKQIAAPEAKGEPLDTLMIDNEEIQSLSQEDMELNDPWGEEGGPKDGEGDPRESTLLDDPWLQNSSVLASGSTSQVVNTRASSSTGATESADPLPITMSLFLSQPILISALSLASTSSLQALKLLCQHRNEELYPYRFDLLEAVPGWVSPNDLEAVELLPALDSEDNEIWVRPVATSPIVTHYATPKIISDLYLPSSMSTIPPTILLHPRQHAVSPSDLTKWYTTHVLSLDEVGILDTQLAWVQHGASLGVPSLDSLGEDLSLLSRLVYDANLTQDQHAKWTIGNWMCAKESDIIAAYLSNSTPESIASDVRRLVMPYLYVLESRAERAGMPSANLVSDSLSSTILSLPLRLALPLFEASKATLPPSERVIRDDLDVARLALSCLYGSQERGGAVWSTMSSIFECLPVWELTGEDAEDEELTSTTLDSISNFLRPTSASTPPPTKSDILFFFQPLPFASLSRALDILDVQLESGEILARWGVEKRLGELLGMTGDQKGQMELAEKLARQGGPSIRKGGEDRWRKLWNDMERLSSGEGLLKGALGTLTLQARGRIYFDGILRSGDFEIAKTMLKMLQAEGAIDNSAVEEVVLKVSKDFYVSADSCNIYTGNMKLANDSLSVAPSTPAIVAERQYIEATSRLSSFSTFTLTPREIRHDVNPLSLLSAVLSDNSSDAFRHPDLMLELAEKLGCRGDTDRGLVWGIMGRAAIAKEDWPMASKAVENMVQTVKKSQDSQTAVKQEQQSMANSGSTLRSETWTLAQTLSSQSEFSDISAKLSFVSSAIELCPASEIPSILETFRQIEKGRIRLDEAAKRRRMKGIAAPQLPSEPSIGVSSVAAVQERVLGSRTAAKAAKLALDIGGRLTAHRQLPSPSLLSSATFSSPFAGYELARPLSRNSAAGSEGGSDGGYKIGGSLSSGTAGARDLFEHLGREEAERVRKGARRALVRGVGWLLGADESEIAGAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM26</accession>
    <name>A0ABR3BM26_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612217.1">
        <property type="nucleotide sequence ID" value="XM_066759570.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991968"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="179" mass="20931" checksum="809B889758BE861E" modified="2025-10-08" version="1">MYISFFHTVEEFPKDRRSNQNKMAYKAYTGFAMVEPRSNTQVAPRKVSPSVRELPPSLLVSERNFKGVKLKDDTFFLIVDQYQRARALKIFDNQGMKAIGEISEVYRWLKMFPNVERVEIKASALISSPEDDVQKKIRRNRSYEPETPVTHHFQQQLGDRFEELAIFIDGDYGSPQDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM53</accession>
    <name>A0ABR3BM53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611028.1">
        <property type="nucleotide sequence ID" value="XM_066760756.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993178"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="421" mass="48126" checksum="9AB92C258A64284F" modified="2025-10-08" version="1">MATANDTSMSLVSVLGASALIISVHHAYKFDKCKCLIPKKEEWFRVLLTWMLLASIFCLFTWGAGWCYIKYKLGWIYAEGYGAIPYPNEMFSRRYVKLNIPLTIIFNIAFSLQTSLNAEEGLYWYHLMRAVRQPKSARSWLTSTFFYAWIVISIVSTMLQCSIGWIHRGKLNMNRQMATVMAVDGIIEFAVLCAASVVIWKFPAFLDNVKASGAGPEVRSRLHFYHEANKVRTFFRFLYSSCMMVLGIDGLTTRRLIASTPLASDLLSQMIFGSFFFMLIISVMLYLPRNWYPEGSQRNNIMVGAPRNALNNDHVQLASGVALMSLLREGGQWDTDDMRTKELQGEIPYNLNDPKMYSPEEPLTSKEMDWELERESGLGVPNVLENFTSPIAIPVKENSMPTEIRIRVEQEVHQDRGENYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM62</accession>
    <name>A0ABR3BM62_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612252.1">
        <property type="nucleotide sequence ID" value="XM_066759605.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992004"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="110" mass="11026" checksum="E445B3B2D9571D0A" modified="2025-10-08" version="1">MSQPQQGGGMGMMNPMMGMGGMGGMGGMGMMNPMMGMGGYGMPGGGLGSGAYGVGIGSPYTSTWLPSWVQQLILYGDYGIGMGAMPGGMMGGIGTMMGGYGMNMGMPWGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMH4</accession>
    <name>A0ABR3BMH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612351.1">
        <property type="nucleotide sequence ID" value="XM_066759704.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992103"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="323"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="769"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="984"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1089"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1153"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="769"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="831"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="879"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="992"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1022"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1153"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1163"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0243984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1197" mass="127624" checksum="1CAF4873DBD70EBD" modified="2025-10-08" version="1">MSNSPSLGSPIPIIPNLTPSTSPRRNTGLSPPLLPRTGLLPAISSVRRSSGEFESGSPSSPPVISSRPSVVMGFSPAATHQVLSAVPESFSTSPRSGPLSLNTKRMNSRSPPLSTPIDQAFQFAEGSPRPQPSSPRNGGLNSDYLPRSRRNSAAIVSISLSSRSRSNTPQGGSATVSGHNSGNDTSNKTSAAVTPRGNEQPLHMSDSWAPGVDELDDWQPAGGMLLDHGDDEVSAVDDYMDDYGDKVEQAWSGFSDSSPVVEDVLTPGMVIGEGLKFQGEIIVPAVSRMAMADGSDVGLPLRRGGSEATKVLRQDGRYEKKRYEVVRRLGTGSYAVVYLVKERGGKKEYALKCLSKQDLKDEQLETQLFEAHIHLSLPIHQNIVTLHQTLQTRRWLFLMLELCPGEDLFYWLEKSRDASPQAVHASLPDERTALSSSKLSSSSIPFSSSQMFSNLNSMSFSQSPGAAFSQSHSHIGASPASLLFAHHNGGQYSSHFTPSQTPPTPSLLSAFSANTLLSQRRLRLIASMFSQMCEAVAVCHDAGVSHRDIKPENFICCDSVELEAAADGEFGEDEGESTKPVNFGPQAKRKVIVKLTDFGLATTDYESGDVECGSKPYMSYECRNNLGPSYLPAPADVWSLGIVLINMLFHRNPWKDPTHGDPNFDNFLMDPIGFILSKFTGIGREVASYLADHVLCIDVDQRVSAKQFGAWIKTLPEMIGGRKAMHSLKLSRLDTHKATTVDKGMFMKSPMGNSNVGKKFSTSALTSAMSSSTTGLGSTPTLSGLPPPSSLLEEDEGELEQESPVREQEEVIEPEPILPTPPLESDGMYSVATSATVDEQTTPTDESAFPSPSAALSTGISDEQDDSRDCVDSDTRSLSTHKRRKRGVRKGKAAQAAAAAAAATDDPLSQSSRDALLSELASASQSLAREMSKFHKPSVDVNRIEDFPPLGVTAAQVAAEKKSKWKDMMKLSQGNPELAALAKRVKERDSDGSLNLSAPAQLQGSERGGFGAKSGKGRNAHTFATTSLTSGATSTGAEDELGVKHAAHRPRKEGGDDSRSRKAAQAAAAIAGGMEPMGSFGRPSHIKPVHHHAHTTGSIDYGIPSPAPDANSFSAQKAQLKNNGQAIPPASQKTVFKPALTSVDSATTIKAASVVSESPSSPGTVTLGPTSPNKPKLKGQISTLAKMLSGLKTKGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMU2</accession>
    <name>A0ABR3BMU2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cohesin loading factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611595.1">
        <property type="nucleotide sequence ID" value="XM_066760291.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992697"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="86712" checksum="06A7F613B709C50A" modified="2025-10-08" version="1">MSSTLPRPLVTVSTLNNPPSSDTIVASSPLNATAPDRRPHLQSDEHLTPLKRRKISPDMFEPTAVTGRLSNQQHAPVPQSPCIPIAALLYHYAQVAHQTSHVHLQQAFVPTHVSTDRSSGYPIIKLYSSSSTQQSSSPNRFNHDPQAFAKALGLQLYALDLLRAGLGMNNLSDMERVAFSLEFGVVGIKVYMAQQQILQSKSKGKEKEKIQGAQVVDCQRLMDDMQDIVGQAFFVAQRQSSLTLMRLELELVNARLAFMQGKFNLGKKLVQTALAASRDNAVHRYSLCLLYLEYVESTGSADFQIIATEFLNEARRNNHQMIVQLALLIKTRIAFVHRRWELVPTVLAELASSIGWSDSSPSTDLISGQKEERTWLACLNIHYLILRALWEGRIGNDNVTKEIMKRAYALMDETADKKVFNELRANGGVITLHIPNSRPLQVQTTPPNILYMLTYLTTVVARRDFTGSNATCKSIVHPRVMRETENIARTEDMWDSGFSSLHSLSQAIALRKQVMSIKGEVMIEQATAMIYRSCFAEGRQLLYETVEQLHDHNLFHPLSPHLCLTFAQHAHHLGLTSSAVRYYKACKDLINSGSELSLIAEIGLLAVQNKLEGLDQSVERQDEVNALAEKCKGSSSAMFSAAGYFLASLTDDNRVNSKKKLSTAYEISQKANNNILRLLIFAFTTSTHHYGGRERMLRQLETGRDISKMLGGKDRDDGVGQVVLGMWFARRLKEFYRQEGYQQGVRVAKESEKLHFARLNDLRREAEKVVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN85</accession>
    <name>A0ABR3BN85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612612.1">
        <property type="nucleotide sequence ID" value="XM_066759125.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991516"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="213" mass="23415" checksum="F45780F244128E51" modified="2025-10-08" version="1">MASSGTTSNNTQNSSDQGKYSKKVAKTWPDSSSTKAKKAAAALSQNVEKAYYSIAESFGGEKQINKFESIGVLQIIVPIFQWPFTLLASFLQFTFLYSSGIEEMQKGFASGQSAAKVKSILTVFVITSTLQLVPSFFFDTHCHFKALWGFFLPYTLFIAPWKDAPEQTVGALLCDTLFTPLSTNIGIPFTSIFPDHDGQITAMLTFIILALML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN98</accession>
    <name>A0ABR3BN98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612627.1">
        <property type="nucleotide sequence ID" value="XM_066759140.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991531"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="755"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="758"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="786"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0245543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="957" mass="106306" checksum="1155C730DB602846" modified="2025-10-08" version="1">MNDLSAASREKVRRGYRACLHCRSRKAKCDLGDIDAPSSPPCSRCKRESRECVFAPSRRGGNNKKRARTDSEDISKEDDDPPRALARSTAEVTSGEENPAQTFPYPQPPPQPRHLSVHNLLGHSPPPARYLQQFGHTSSSTHSSPQTNFSAEHATPQTRPTLPSIQSHTATGYADSPPSPRRKRMANPPLHAADPSSIVVADMRNESDALQILALASGQAANREGEDERSDRYDGQSAAGTVDSTGMGGHQQQMRGIPSSPEKEIQLAKLAQFSLVKMGILSVEQTRRLVDMFFKCHHHFFPIIPSDGIPRTLEQLSVFAQNEKYLLATIIIISSRVENTPEMREIHERSWSVMRRWISKVQCLGEPPTIGLVESLLLLAENLPRTSCEQMSDDSTETEAIEEPHGVENRQAWQMIGLAVRSAYEMGLDKLGLQLIPETERTLELERAKLVWVYCYLFDRHISMRLGKGFWTRGGAVCFQGYSSSAQTGPAAALVNFPFLREIKPGDPNSEHPQDDLGSLVQAYLELTMMMSNAHDVLYPNAARTRSLVVYGEYFKYIDEMARSLDGFKILWRRKKWTLFPLTDTVWVMFYYIQLYICAFSFQAHVERATIRGEEEYKILEQRHKEQGGTTKLARPSLTLFPRGAAQSPDARYIFQMCDAARELIHICVDNLYPGGALPYLPSRYLLWFTYGAIVLLKAIYSGAMLRADHKRTLDLIDRLCICFAQCSTDEEYPAVRYGKQLEALRNKLAGLSDVKTTHSPSAGSGSQAIRLPRTQQNRAPEVRVSPSQTATSPNTLPPQQQFDPRPSLASSQPARYHAIPSEHAMNTPAWQLPVMQQYTQPVTFPYPTTPVPIPAGPSAEMPAAPYVAPPHQQPFMEFGVAQSSDGLNLGMNDHNNLGFTSLDDWFGFGAAGTGGGAGQDGNGVDDPMGLANVGLDLQDFWMNVGPGEAQGGFPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNM8</accession>
    <name>A0ABR3BNM8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612758.1">
        <property type="nucleotide sequence ID" value="XM_066759271.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991664"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="792"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="848"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="905"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="384"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="564"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="624"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0245674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="933" mass="98735" checksum="67BC501AA5605561" modified="2025-10-08" version="1">MDSSRSSQQGKRSERLTRTPYARPTPQKTRGTPNSALGAIKSALSLFTSPFSRSPSTLPTHNAIEVDQRSESGSEDNWDGEAPATMKEQDVFSLAAAAGRSGEDFEGRQIAWRSKGEVPGSKHDVVRRGLQLAPPKASIGIQNGQPITPNTPIFPGHFNRDGAASQTGPSHSKRALPAPLVPSSGILKAITDQNSTTSVTAEPKSATTSSLSLPSRLPLPASFMTPTRSAIASASSSQCALALSSFLDDKQGKVLTSEDRTIIEALSARIAVEENASPAIQERRGGWLPSSTSGEVAFRGNLSQSSSSSSLGSGSPYKQRYLGPGMSPKKMPSSRSSPASSRLQSNQSNSPASIGPDASALPPSFPNRHLVNTILRYSAMSSPLRQSYRPGAPSTPAAAAPEPPVSSPATGGKRKPESSADPAVSKRRQIEAAGRQRATAIMQSLIEETDTTTSKSDIEPVRWNAYDRGSLHAKATEEPFAGPSTPAKQVPAVPISTPSTAHAGSTPRKRTPLRGAAAKLEAHRQAMKGAKPLSTIERIKGVRPWENGQSSISTPAHKDKETEQQVEEPEESEIDELDSERDTDAADISEVEDTAKARKRATPLKPTEEMPQPSKIPDATKFEPFPIQPISFSSSSISKPAPSSPAPAAAENYDSPLRKSIIEAPKKAEESAKALTFSFDQPTKPTSESETEPVIQPIVRSAVRKTSEQEKTDLSPKEAALKVDKLALPFFTFIPSAPTSIPANSTKEQTEKAKSEAAKSSPPTFAFKLELSTPIRASSAPSSSAVKPANGGKWTCSMCMLENPESATEKCTICEEPRSKKSAPAAPAISGSFGFGGFGAPKTGGNGGKWTCSMCMLENPDSAKEKCQICEEPRPQSTKAASTAAVSTPFTGWGAGAQQKKQDGGSWTCSTCMLQNPDSAKDKCTICEAPRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNQ8</accession>
    <name>A0ABR3BNQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612786.1">
        <property type="nucleotide sequence ID" value="XM_066759299.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991693"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="45204" checksum="E131C2BEA62C6198" modified="2025-10-08" version="1">MTQPRPYRAGLGIPQAVTITSGPAPLRSAHDDIDEYTSPSGSTVQPSADAPPQASISRQTETKTETYVYESLPKHAAWREWNINPSHHGPERLKHPPVFVKSQTAYDEVGRSVVDGIGVEVSLGKEEDKSDKILDNGGSVKDWYLSLAKKSDVQQEGSQLSSKSAVTVTETTMEPVTTSSHLDPSAEAVRIHPSEWFIRRALLSKSQTPNSTPETSRPATPSSITSLLTMPPQAQPNKMAPNYALGPENKGYGMLKGFGWRGGGLGKPEGWQEENEDLTKEDRKGKRRGQSDDGIQEVDASGNAIIDLTISSSEVSSSEDEEAPSGPGRTAPIPTALKLDRLGLGHRSASESKITHSHKEIVQAQKRAKYGQRRIKKGEEKGEMGKKQKIDWKKKDRREREERRRLMAALNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNX6</accession>
    <name>A0ABR3BNX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Signal transducer</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104875</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612824.1">
        <property type="nucleotide sequence ID" value="XM_066759337.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991731"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20824">
        <property type="entry name" value="C1_SpBZZ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09394">
        <property type="entry name" value="LIM1_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="82"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="987"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="1057"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="586"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="877"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="659"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="804"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="587"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="883"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1253" mass="136085" checksum="97742EAEBB19B32A" modified="2025-10-08" version="1">MSTLSQHSTTSLNTKKSSTKPPSSILSPRIPSPTNVPSSVGSPNPQHHHHDHMHAHSPTGTKHTGLGIPQGDGFPPMNGMDPKCGGCGLMIDQESGGVVVAFGSSLWHVDCFRCAKCQEKVSADTNLLLLSDGSPVCGNCSYQCFVCKQAITEEAIMTGDESYHAHCFTCRTCKRRIEELVFAKTSQGIYCMSCHNERVAKSRRHAEAKRQRQARREAKEREREEEEQRLREEAARQAASSGGQAPPLNYLNAGHSTLSSMSLSKFAQKPQPRPRSPCAGATNAGNAFEDAERDNTHVKPRSGSPAGRQLIEAQNMPLPASPSESNDGSQLKPRTSSPQIRPSPHFVSQPGLGVPTSKAEKRRSISPGMTFNLDAQNSTFTEQRLGTHPPSPLRSSFTDGSGAVSNEQRPVRSPVSPSPTPSGNHTFPFKDGFESGAKLQQAQAQATGQLSRSGSVNEAPARTSSLPEHLANRAKSDEHFGLETHSSQPDSAELVPGPSKAQPIGDTPTPQLHAPALPNMSFSLSDPDFAVILSNMDQSPQKIKTGEKIKPEVEIPSGGSNPPSPVISSPSLARSPTLDMLSAIESDPQSRSQQGHLTRSRLSPNDSSPHMLNKRQASADSSFSVRSRLGEGSFERLVELLAGAKFREEESVNVEVGLLSGIIKEVEDLKEAMVSLKSRYTGAKRSSQQYSEGLSVAGEEYDKERSKRTELEAEVSRLRAQLHSQTARLSVISGDEKRAEHMKRRSRDLASNLTGLERDISKLRAERDMKLAEINELAERTPGGGVVDPVSLAESLSLRLESIRDQYATELETLSGQVENLEHEISELRQIKEASLEESAALAAKNEDLAELNAQLTRQTEALQDTLSRMRPPTIFNKGKGHQLQNSPSLASLTGQGLQDVPEETITARVVKVSKPEPIEAAPVKRFKWYKSSKGPDASSTPANISKPMASFDVGKTRGGMTLGVAGLAMGGIGGGPRPSTEFGMRDHAFQQHTMMRFTRCELCGEKMWGLQEVKCSSCGIVCHSKCAEKLPRGCTGTKGAVKDEHEGPLPPSMFGRPLVEQVSADKQSVPVIVTKCINAVEAVGMEYEGIYRKTGGSSQSKQITLLFERGDYDAFDLADVDAFNDISSVTSVLKTYFRSLPNPLFTHELHESFVTAATIRDTNNKRQAVLALLHELPKEHYNTLKALMLHLNRVTSYSGVNLMSSQNLGVVFGPTLMRSSDPNREFGDMAGKALSVQWLVDNAPSVFTLDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNZ4</accession>
    <name>A0ABR3BNZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612877.1">
        <property type="nucleotide sequence ID" value="XM_066759390.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991785"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="178"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="273" mass="31516" checksum="31A5037999C6294E" modified="2025-10-08" version="1">MPGPSDSRRRDDSRSPRRDRDSSSYHRRRSPNRPNSGRPSKPRDNGWGDRDKVGEREKDGGYDRGSDRGDRGLYRSSSRRDRDGSYGEKERDIERAKDRKRYDDDVKKEGPDHPPVEPEKPNFSNSGLLAKETNTVKGVVVKYNEPAEARKPTKNWRLYVFKGTEQIDLIHIYRQSCYLIGRDEVVTDIPIAHPSCSKQHAAIQYRQMTERNEYGDEATTIKPFIIDLESTNGTFVNDIEVPKSRYYELRASDVIKFGTSSREYVLLHEDVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP00</accession>
    <name>A0ABR3BP00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">I308_104934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612882.1">
        <property type="nucleotide sequence ID" value="XM_066759395.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991790"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="664" mass="73293" checksum="EF2D017DE77CD87A" modified="2025-10-08" version="1">MNGSSEQRSSSIIAFEDLRLSIDPTTISLALGEKPVKSIEGDGTLVYDEHKMPDAKLTEQLERIWNEYPSGLLEVTEQKLERLPPNEDANKPEEEGVDEAKKRDPFSMMTYEEMEKLRSEIFLQLNDARNELWFVLELAKTLSLSSSFTTQPPPPPTALHQKKGKVKPAPPALTTLPSIPGEPPILPPGTFSTTLSEFPAKPLHAQIYELEQLLLAKQIALNECQGLIDGAVGELRLMAHAGDRFWKDIRNLKEGEGGRGKWAVVPKPDFGRVGGKGEKAKDVIIPYAIDEAPSGTRARCLAGFDLDPTKKNGLTFGDRHHLRLRATLRDDSGSIISSTPAEVEDQSDVRAMMDAAQMEAFDEDLFNEIRFVAARIPKSEIEPQCVSFPVADQVLSFELYNTRSSPSSSTSSICDVIISSIRLSLLNIHRQRKINLVAPSQNLTSPVPSILQPIIDTLRFRQLCSVVGWTLNEFDKTLRNARLDSRIQKELLKDGQDDVNEMREVLLGKRGVEVLTGKYSLGIDDSYAIVVGVSAPYSTIVHLSSISFPLANPDELSQVVSDDLSIQLLRLAARHLHGKLGDEHKEGLYCDTLEEVVRIGEIALLRLSIIAPFYAICGSVESERISVPAYDSRQSGVGIFAWLDTVTQSIENSLSSSGSATRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP10</accession>
    <name>A0ABR3BP10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612896.1">
        <property type="nucleotide sequence ID" value="XM_066759409.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991804"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0245812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="146" mass="16160" checksum="9FD17DD88BAEA65E" modified="2025-10-08" version="1">MPKDPYTAIQESLEDARPQLTAFISGSYNAQQTRALLKLLDVIQDAAYSYVKSKKNKKKKGGDGDSREAEQVKIDWLDTEGVHLWNLASQVNRATPTTPKLSKDELSTVAALRLTGFRLVEAATDIKGPTTCKYQALATRLTTVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP20</accession>
    <name>A0ABR3BP20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA endonuclease activator Ctp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612736.1">
        <property type="nucleotide sequence ID" value="XM_066759249.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991642"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033316">
        <property type="entry name" value="RBBP8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107:SF0">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107">
        <property type="entry name" value="RETINOBLASTOMA BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="6">
        <location>
            <begin position="548"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="594"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="67"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0245652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="673" mass="76147" checksum="B28A4876E2BDF5BF" modified="2025-10-08" version="1">MDIPKRSQLLTRTRTDTERASRWWTEGIKASASASCDLPSVLNSPSKHNRAMEEEIKRLREYLVAIRKGYERQIEEEENISMNLRDRIGRLEEKFRKEKAKVEQAQVKESEMKVSLELLEDQLTRERDDWNKFMHDLKETLAKEKDEKERLQQEIDSLKEEKSRSAEVSAAPPTNVFMSPRALQPINTNIPAPLVSTTPSTPSRKVAAHPPSPSALRKSYAHLESQHKALKVAYDKLNERHERDMRYLKTYAAVVADREERRRKKRAEKRAQRSVRKGSAHSVSFSHEGNAPATVYHKKDNAGPAMPSVTTDDETDFYEAIEATDKQIDTGNVALNSTTENGQPASIRTSILTNTTLQPVSIPIAPGAQSLAQPQNQNRASPLTEPPQPPATPTTWKRKGSDNDLDLLSPPDKTSTVTTPSVFSRNLVRDRLRESSLRKAVISRAHGAGAPNPLITRSETSSASTPGPSSTKSDSSGAKRKAVDLEGLSPAEKAAQRRLINKLPTSEKRELYKKYKKGGRYMVPEALERRATEEFEIDPAQNEGAAFAFHDVKRKKTERMQMHGGDCECCKGYYEAVGVMPKFHQAPSWKDQEQLGEEDEEHAAREHLNKVSRHREDWVKPPTPPGYWQIGFPTTQEVEEQNRKADEMARGRDERIRKEAMQKGGKWRKKSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPD4</accession>
    <name>A0ABR3BPD4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613012.1">
        <property type="nucleotide sequence ID" value="XM_066758564.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990940"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="305" mass="34023" checksum="C1292A53E9E1E8F4" modified="2025-10-08" version="1">MSGGDYLNFSPYGYTPAGWVCVTFIILFVTLACVHTALGVKFKYWIVFPTLIFGCLLEIIGWAGRYWSDQNVLYNPPFLMQIITLIIAPVFFSAWCYTILGMGINTLGQQYSFFCPKWYIVIFVTCDFISLVLQAIGGGWAASVDPPTPKTPTNIMVGGIVFQLVSMIVFVGLAVDFMQRAMRRRAYKGRGGEEVEMLPSTPELEMGMGKEEMYGAYAVARVTRAEEVVKRWRGVMVGTGICSIMIIVRGIYRSVELTQGWDGYLITHEVYQDTLDGIPMITALLATAVLHPGFFLAPRQGWKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPH3</accession>
    <name>A0ABR3BPH3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612504.1">
        <property type="nucleotide sequence ID" value="XM_066759017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991400"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="305" mass="33766" checksum="E3A1FD557134772D" modified="2025-10-08" version="1">MSSFDPFETRIQFISLLRKLNASQQSIQKVTSFAINYGSRCGEDLWECVIEQCNKGTLNTRINILYFLDALVEESLALGPSEAPYGVLLTRDLKTLVDSVVPDTNAGKLNLKSARQILESWRLRRVVDPGVVAEVLKSLEGRKFDSGPSQKRTHEHAFSKTDIVRRMEEDRERHKRLRERIWILPIPSLHPSKNTLAGPTTLSSSTSNASPATPASPHPSFLGSLAQHQPQSLQVSASVSAAAGARAEDDAAVPESALDVEFEQIWDRVPEEGLDDDDLLQMRADMRRAKLEIAPSSTAPIQTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPJ3</accession>
    <name>A0ABR3BPJ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611898.1">
        <property type="nucleotide sequence ID" value="XM_066759952.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992352"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="17"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0243531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="299" mass="31894" checksum="92C582FFEDEDB07D" modified="2025-10-08" version="1">MATAGPSRRPDGRTPAQIRPLHLSIGELDRADGSARFAFGSNAVLASCSGPIEVRLREELPDKATLEVNHRPLEGVGATPSRALVTTLETIFPPVLSLEMHPRSLVQLVVQSLVPSAGRAVYGSVIGTEGVGAEQNTWPATDMDEYAYVQECKRDAARISPAAGYTFTARAASINASTLALLSAGTISILALPVSVALVVTTEGRVMLDPEADEEKQAKARFGFGWAWGAIFGTASEGNSMEVAGQSEGDAELVWVESEGNFTRQEWSEALEMSKTATKAILEFIRIQLDAHLSSRQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPT3</accession>
    <name>A0ABR3BPT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="14" type="ORF">I308_104241</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613167.1">
        <property type="nucleotide sequence ID" value="XM_066758719.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991097"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5044932280" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044932279" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="118"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="490"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0247206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="524" mass="57895" checksum="C7BA0A2E6CC4BC13" modified="2025-10-08" version="1">MFFPQYGRVVTRSVNISYRHPTSVPICARFRRETVAASRPFVRSNSTKLPKFEPSGFKAEKRKTGSTDNVENHESSKGKPLNEKVAQAWSTPTKWYPIPIALGALVLLAVQYRKQARGEIEVETQGPEGAVIRKSGDRVDGPWQVRVLGALPLRSLSRLWGYLNGLVLPVWFRPFGFKLYATIFGCNLDEVPKDLKEYESLGDFFYRELKDGARPIAEAPMVSPADGRVLHFGEIAGERVEQVKGITYSLEALLGSQSDIHGHPIEIPRSRSEIVDDEHFAKINNIPYSLSALLGQGPRGKGAGADYSEAEPVGKIEDASHPPEGQELGHDASVAASLGTSALGSKTDGSTKLPSLSENSKLFFLVIYLAPGDYHRFHSPTTWIVERRRHFTGDLFSVSPYIANRMKNLFVLNERVALLGRWKYGFYSMIPVGATNVGSIKVNFDEALRTNTRVLTHPPKTYAEATYNSASILKGQPLLAGDEMGGFKLGSTIVLVFEAPENWKFNLTAGERVKVGQPLGAFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPZ6</accession>
    <name>A0ABR3BPZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613222.1">
        <property type="nucleotide sequence ID" value="XM_066758774.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991152"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="93"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="373" mass="41451" checksum="FBFE83E663A173C5" modified="2025-10-08" version="1">MFSCTPSTPEFQPVSPCFEERTHPASMAPCGIHNPALLEFIRTDVSRELVYYLADRTTSVIDQATKAAAPYTPPGTPTKKGADEALGLPSLETFVAVVCEQSNVQVSTLLATLVYLERLRYRLPKVSKSMPCTRHRVFLATLIVSAKYLNDSSPKNKHWFKYAQMFPVSEINLMEKQLLFLLSYDLSVDEQEILDNFQPFLSQYSFYSPSVASSPEIPPTPVTPARPATRRSSHKRHHRTSSRGSRTYTAPPLDRSGSSSSLESEDMPLTPQQPPSPVMVKAVRRGQDKLLVGQRPAVVYEVPVANTQYLTQSMSIDSITSASQSKVAPTIAAPSVKEGILQRLLRSDRRRKQAAVQETDKQTLAAVSSWTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ80</accession>
    <name>A0ABR3BQ80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613302.1">
        <property type="nucleotide sequence ID" value="XM_066758854.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991233"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38973" checksum="25CC0E21548A0998" modified="2025-10-08" version="1">MTRITTPSTTSTITTHPDILPVILSFADRQTLSRCMQVNWKFFHIASTYLYSNIRLIPNEADAFLYGASFGPIILADGSERDLKRELLAMVKVLNIERHQGCNGFIATACSRWRGLGIEFPSLNVLRIWVGPNMFEGGWFNCPWIPNMSPEKLVMRNVTAISAGGSYTFAPRDLLCKVQKVVVVVSKLRNLSEINQDVLRSHRRTLESPIQPGTDTVIVFWTKSPDSGWWAEAPLADYDNIIDQIVLCSLAEADRLTICNAGSMYPVMSENGDCTTYASYEEREKEVTEAVKRKIEQVSRRRGELVRLAKRLESLRFMTFGDYLGKEDWKGEFDAEEVASWIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQC1</accession>
    <name>A0ABR3BQC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104134</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613060.1">
        <property type="nucleotide sequence ID" value="XM_066758612.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990990"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0247099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="639" mass="72434" checksum="F5C254D9B0A7AB94" modified="2025-10-08" version="1">MIAPKGSQWSEANPTRHFSSTQSPLSNSGSRWTRLVSAPCDFSLSVFISTLKTLSLHPEKLFQVVLRGDILPLHQSSISDRLFKGAEDGVKTAIPGLELVERIRTRLVPNQPQRYSKLDQTSSIYRFSGHPEITPQENSDITTQNDSGLVIFTPEVNSIEQIPYYYPQVNHIAFLWDSSIIDDSSEEGTEVRARISVHYLQTKSPSWTSHAPTDAQLHLTHPAIRGMTSRLNKPKRRSPLATVSQESDVDRSQKLGVVDRSQLESDGMARSTKELEDDLYKQCQHLLEKIFKYCQFANSPVLHPKNGAVRPPESFESLYLLLQDRHRHLNLSLSKTDMVKHRLSKLHATPSDDSGIPANNVSEWGRRDVAVAAYLMLLWKDMYPERPNISDKGKGEDVRKWDTWGRPEGGFVDLGCGNGLLVHVLISEGYIGKGYDLRPRPSWNMYPTMTKDALVKQPLDLPAWFPHTEKEWELGSWPMREECVVRDGIFIIGNHCDELTPWLPLLSIIPSPPVPYISLPCCLHTLDSIYSHVEFAHSSQWSNPSILLPAELDPTKSVYDSYIAWLGWCSSRCGWEWDIDKVGHGMAFDKGWAIIGRKRWASAKDNVKCRAWVLAGVEAVRRRGLFKVKENANDDHRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQG8</accession>
    <name>A0ABR3BQG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613379.1">
        <property type="nucleotide sequence ID" value="XM_066758931.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991310"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="553"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="72714" checksum="C53C089FB32891AE" modified="2025-10-08" version="1">MKYGKEFQQLLDSSYFPEEWKSSAIEYRQLKKVIKDVVAELTSMGLSPDILNKLLVVDDHSLILDGGDSNSRETPEDELIEFEFESEEGSPSVFRYGHIPLHHQPQEVLVDPVRDDGGYPGTDNLHPHPHKFRLRLLSETSQVTGPCSDERLSSRRGSEGSHRSRRIVKRAVGIGHGGIKAEYVVTGAPDHPVPQIRLHLSAPTSHLPSPSPSPSFTKSEIGTDTETEDEDPPVDLASRTPRPFDRLYMLPASPSLNRVSAAKSPIWAIASTGNPDELSDLSLGEAAFEEEEEESVPITRSLEISEQIPHLEREFIIPLSSDFTFFSLLTTALTSLSSFHARQQILFQQSVEKLCGMISKSISPQASIEIIPTPFTPSNEMTPSIHISKPSRKDLYAWREIFTLWIEAQIFESIAERDRGERTVEEAELRLQQFAKQVVKRGLGDRRTMKGKKVREAWEEFLRLNVLLLDLKKFQSANIKAARKILKKHDKRTALTASTGFQAFVRSTLSAPTDKDGNISTWVFYNTSLPHVLLASLTSTLLPILPSLDDYACLICTSIAFKPIRLTCGHLFCVRCLVKMQKAGKGECPLCRSDVILLADKTCLDLAVMNFMKEWFPKEVKAKQKENDEEIVKEQAQATGMDTRCCIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQH7</accession>
    <name>A0ABR3BQH7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613392.1">
        <property type="nucleotide sequence ID" value="XM_066758944.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991323"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039965">
        <property type="entry name" value="C3H7.08c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="134" mass="15249" checksum="63EA182E36633E25" modified="2025-10-08" version="1">MSSSLPPHDPSIETPQRKLSATGNLEQATRRVNRFAKRDPALYPLAFIVTGIFTVAGYMFWTKSVEPEPAKKLVSTGIVNPWDSADKLETYPSSVAQFKYRYKTRDGHYEDAFPTLNQSMEHLKDNNPHKYRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR23</accession>
    <name>A0ABR3BR23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613300.1">
        <property type="nucleotide sequence ID" value="XM_066758852.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991231"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="2"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="398" mass="44773" checksum="0276295717CF3537" modified="2025-10-08" version="1">MWFINNKIIDGLELRNWMGTVHETVVAKHAARMGLPFSTSRIVNMKINIGEELPDIERNRRCFTDGCGIAGREVLNQAAPALNEKVGINAQPSAIQFRLGGAKGVLSDWSQLVNEYEIRLRPSMIKFRSDLADLNVIRIAKYQAAFLNRQFINIMCANGVPHELIIGIFEDAIADIKGFRDRVWNNAITENDEQLIALCNDFPLAQLIKSGFNENPLVLDVAAIIELYLIGIADETGTLKEGEVFCQFHENDESPPKVVVNEVLVCRAPALHPGDVRRAWAVDRPELRHLKNVIVFSTQGMRDIPSMLGGGDLDGVDYTLIWDQRFVQSLKVYDPMDYEAPDPISVKHVTQKHLNENFVQYVLNDVLGQVDNCHLALSDMYTPFDPRCLHLSEIHSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRA2</accession>
    <name>A0ABR3BRA2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="4 16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">I308_103801</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IND107</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Chromosome</location>
            <location evidence="16">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 16"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613684.1">
        <property type="nucleotide sequence ID" value="XM_066758282.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990657"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 16 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="16" id="KW-0779">Telomere</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="19">
        <location>
            <begin position="1974"/>
            <end position="2562"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="18">
        <location>
            <begin position="2664"/>
            <end position="2976"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="20">
        <location>
            <begin position="2970"/>
            <end position="3006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="667"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="832"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="923"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2419"/>
            <end position="2444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="669"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="937"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="2428"/>
            <end position="2444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAL0247723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="3006" mass="335329" checksum="FABD29C0253616DB" modified="2025-10-08" version="1">MDSLHAALALYASDSARDRARALTLLAPILANPANLGAFHAAAAAATPAWLALFHCLFRAVARERAAVLRRDAGNAAAERLAHAIRLVRLVAEQAVHRIARKPLAALLAHMRHQLVASGRIFAPALLDYAKAIHTLLAYPPHRERLDRHTWLALMSMCFGAVLGDRLVSDDELDEHDILGVAHELALLDAESSPLPPPVTLDTCSLVQIIPALLCSTVAPVIPPTMSSGDTLAAGQKVGLGIILKIRRFFIMYPHVTIYHLHLLKALNTVLSEMELNCRDLFLLGGVKIWPHLVTLWAAPERDRDRRIPEQIAIAIHKILPHVNMSADVREDVEKLMEMLWKESTMSRGIEPLDLASTRLNTISHRRAACRPFETRSFSAGHLFSVDHALSWIAIETYCDACIYLYQTQASGTSTPSGTSKRRKLENPLASLISTVGGMARSESRLIALQTLVFIIDKHWSKLASDVQLEIRRTLILLLSDDSEILQSWAYIALSTVVLSSRAEDSQSQDDWQQVWNVALQKCHLPGTSRSASHAAAILLQFNMLDSTLTIKGIQTLLTSIAVQGPPTVHDSLYSLDLEEQVLSWLEKALAGEKFERDYTQRRFGDQTATPGDVLRLFSAVSRIQRHHDVPLAEPVTRALLPDSAVVEYALERAKTRPIRDFLLYHTYPPTPQQPPTPPQPPVAPSSDHSTFLDRRPRRLSDLLSRILDVTIAQWESTNSNPVIISSDTSGERLGRSINLLVLALGFQGLVQLDGYIPHAGCVKAAIRLLHLLKPSLTSSDISMPSLDRVWRGLTCLVDVELQKQQQEEEEWPILVKPDVQSGIRQDLLPPIMYDTPPHPTESPSRDRVSVSTKQVTQFPLTFPSTSTSTHVAPSSFSTFQNHASPASASASLVHAIWKLPDVSAALQGLFPVCLQVITRSSSTSQPAHPSYANDENNGENNDDGDGDGDDDFAITSGETTSAAPLLPDQVADWKASTSLLRSAVAFRLQGVMLANGASRAYKDTPLINAFLQADGVRAVEIGCAICKAIRKGWLRLGADAVEAVVAALGDMLDSYGYARDERLLQLCLEFLTCSAPIWMKNSTSSTSGGDSGDDDLMDEAMRLVCYIATKITAGSITSWKVRLAMLCFIEAFLHYDSAPKLWSECMVQEEVADDDRDDDDDVGMEDENHLFHYISQALCDPDMRVRTRAASTAASALYRPSIHPAEHSIIYDHASRLQAADPTFAEHYLSYVLWKLNCCIASAKQRQRVIFDLYETAISGTEYSDHLQAGLDAVARRLGLSSITALYLPYAPTTTISHDTSRSSAITFVLSTTHRLFGSSSSRSAFFTACLEHAGAYMLYCGKIGLFTSACEAAGVLPKDLALQHSVAAAAMAMVLFYSNDKTKTNSLRMNKCKAEAVALLSTFPGMSGDHPAAEELLHNYANGVAAHLWELMDLESSVDEIVAWLDMMEKDTAAGNAFAQMMANDDNAKTGKVKAINPAASFQSIYNVCKFLEKDYSSISVHAFTFAAILRLTSLINNAFLVSEQRRYLRALAMLLSVYQGTLQRPLIWEAFLTETITLLLQPDICRTVLSMVIWAFDRLESLSSTPSKLVNIFCQLGEIRIELGGSGISSSSQPNQIGDAVEEWIVKMSPKWSKSQISQEAFERAVALWPDSLKNRLSVLAIPLSLRDLADLSQNEAVHNAGQLCKQFLHLADAEHRQDVASVFVDSTFWSLKDKISRLWDKGGINAFQDLLYLCNGEVRAPSLDFYGQDTSGKALTATSGQHRKMEAMNALHLAICKTMVQPLHDRRPQIRSAAYCCLQRMKPILTGKDLKALPPDISDVVPILVPIPVGSTSQSQAIQLDGIINSAAWSKKAENFATWSHELSRLLCKVASQHDKFFLSFEPLLSTPLFPLHRFLGHFVHASLVCSRSMNFERSKAISEHFEMVLKNPFASTEAVQSIVNIVLELRKYEHPFKSGMLGYNAWLSVNFVDLSKAAAKCGLYVSALLFLELANDQEGSLDLGEHSVRQIMYDIYSNVEDPDGFYGVHNKDIRDSLRRRLEHEGLSWQALGWAGAVYNVDGNDRKSAIPVLHHLHDIGLSRLASVVANETRTCGSGPLDDPFFADLSWRTGDWNLPIDKKSGSTSSGLLYSALRAVHRSKSSDSASMIVDKASRAEMTRLSGLQKEMLTSIKSTVTNLLCLRELDHWLDPQLQQDIHEAIDKGTVVNLQDINDRFEFASVERIIATRLSVFDSVKQRESQDMIGDALTPKMEMVTKAESMCHIKLSRLALKSNNLQAAINSLTALQKLQDDVGEIDEAQDVFCEVLWKQGEHTLAIQYVEDLLLREKEKKSKGQRIPFLQGRLAHWASEARLKAANEIFGMFSDVAKSIKRSTSDISEHAEIFYQFACFADKQYVNQSSSADVKQLKEYSKLRSSQASRVTARQSRARESDHKDIASREAERDEQKLKKFEIQQKQYLNAALRFYAEAVSMTDNFNDCITRLVTLWLENDKNDESNTTFSRSIQKVPSYKFIFLGPQLAARLHRPETPTIFNSTLNGLMLRMSQDHPYHTLYHVIPLLWEHKQPQSINSSTLGRKSAADDIMMRLTSSSSNQLASGAAKSMKRFVAIAMEWTSFIEKDKRLEYKIPSDSPLRKAPRDIPVATSTPPVDITCQYNDIATFDHFSEWYTRAGGLSRPKVMKCFDSKGQIYTQLFKKDDGFRQDAVMEQIFVLVNDLLNRNRETRSRKLRYRTYGVLALPDATGVIEFVVGTKPLIKYLPPAHEKYHPKDITSHDFLKAMQEVQSVKNNDEKIIQVWTKLKKRFRPVMRQLFTEKYRDPMAWFSMRLTYARSLAVTSIVGWVLEIGDRHCSNILMDECTGELVHIDFGIAFGAGRILPIPELVPFRLTDDLVDALGVTGVNGTFRQCSQLVLQTLIDSSDVVLTILEVFKQDPLHTWMVDDKMKKAQDGNHKMYPERGQEKADRIMRETRENLSKELSVQYRVNQLIQEARDVNNLATIFRGWHSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS07</accession>
    <name>A0ABR3BS07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613926.1">
        <property type="nucleotide sequence ID" value="XM_066757542.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989896"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0249739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44873" checksum="6F4B95937F538B92" modified="2025-10-08" version="1">MPISSDKLQEFTIKAANQSQIELHAEASYVIWPRAQSYEEYWGVYKTERREAPWGKDAFQTWVLVRRADPEGEIYAACKTYRRKSFVKHRGADDIEEGYVYGIASVVTPKQHLRNGYATRLLSLLHRYFGPENTLPPVPESWGKGQPYIPLPPDIAPKVPKGLGSILWSDVGSTFYSRCLSGQDRQGWIVDDALNGELVWKILPNADPLEEDFAWIYQEGLGSVGQELSVRVQNELRRSDTTERSIFMQDPANPGTLFFLPVKGAWMNPEFKSFPVGLRIKAPSGNSTEDAIVLFTVSNRSVRKRFLVTFVSNLDPLQLPSVLKAFDTLATKVGHDEGCVWGLDAESVLVEAWKALSEREVKVGRREEVDGHLLGVAWYGREEDRGMLGDGQMWSWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS11</accession>
    <name>A0ABR3BS11_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613927.1">
        <property type="nucleotide sequence ID" value="XM_066757543.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989897"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0249740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="317" mass="34482" checksum="5D2B74265F08CA56" modified="2025-10-08" version="1">MASPSPSAEELHLLYVLTDSNLPTGGFVSSSGLESFAKHGFLSSQYSYANREFKDGISGKKNMTSGLVDFARAEVSNYASTTGGFVKDAWSCVDNSRKASKAGNGIIGEEVQRVLQKIQVLDKYHECTLLSHVGRRSSKAQGVAMLTLFSRGLSRPAGIDEYLSEDGGGPGSTDEMDVKIVEGYKKMVILEKAPGHLAVCWGVITAALGLPVDRALHLHLFLHARSLLSSAVRLNIIGPYASSQLLLHPYRDIIDQEVNKLRSSTTGIIEDKAKKSGEEEDFWAWTEGAEKGPATTWPLGEVLMGRHDIQHSRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS20</accession>
    <name>A0ABR3BS20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613925.1">
        <property type="nucleotide sequence ID" value="XM_066757541.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989895"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0249738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="44975" checksum="1BAF4A0C508D8707" modified="2025-10-08" version="1">MTLTTDSRTQQLQQFTIQAANPGQAEQHARAAWAIWNKGKTWEQFWEIFQMEINEAEWGKDALVCWVLVHIDDPEGDIYAGCKTFRRNGWVKHRGADDIEKGYMYDVTYVVTPKHHLRNGYANRLLSLLHRHLGPEANLPPVPESWGKKQPALPLSPEVSSRVPKAIGSYLWSDIGSTFYSRCSIGENRPGWVVEEPSITELVWKIHPSTSSIEEPLEWLYIHDLKAVAEELHVRQQKRLREANTSERSLFLADPATPGNLGYVTIKGSWSAATDLSLPAGLRIKSASGNPSDDAIILFTLHCSLIAPRFLIRYVSNLSPAQLSAALSAFDVIATKAGHTEGCVWGLTEEKELVEAWKAQPGREATIGRRPELDGHMLGVAWYGKEEDNGGLLDTQMWGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS28</accession>
    <name>A0ABR3BS28_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TATA-binding protein-associated factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103046</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613932.1">
        <property type="nucleotide sequence ID" value="XM_066757548.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989902"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="1293"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1635"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0249745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1878" mass="206706" checksum="9CB032B2CC11761E" modified="2025-10-08" version="1">MSFRQDKLILLLDSGSSQQIRQTAAKQIARIARASFDAATSKPDAKPHVDDDSSITLHSGGAEGDAWNDTLETISKILALYKSKSSETRHAAAQAIGLLAKSMPEYIQLVPISSVSLTSQPIDLLHILKNGQTLLASAGREYAAKPLPGDKAKRRKAMMASVGLGDAVGWGDDTDKVLDDEDDDMEDVRKTAPPSREASAPPPDVFEGLSARQITMLKRKKGTNIMEEANKMRRLNEKAVGTGSSSAAPSRANSPSLPESSMTPDLKTEVITIDPGAKARAAEAGGQIDPVIDADGNPLASSKTLTMISGQSPWTTVLLEVIPDLHDTTWQTRHGSALVIMEILRSLGASYATAHPELYVALSRQLLSLLVLDRFGDFVGDTVIAPVRETAAQTLGVVLKYISNPGVKEIHQTLMGMVKQPWAKRGKESDNLQKAEKFAWEVRHAGLLGLKYEVAVRGDLLSVKVEGDIKPDVEMGDFNLLDDVVNAAILALGDSDDDVRTVAASALIPIAETLASQLPTEELARLLQSLWDCLAEGGDELGSSTGAVMDLLGALISYSQVVVLLSADNNNLVSRVYTFLRHPIASVRLSVANILLAFSRLSSIPRQWSSDGYFSFMFQNLVLEERQDVRDVSFRAFETSLVEAAGMPEGVDGVFGGDVEDWYSIVMTPIGVALDTSLFRRPTKATGQTHNVDKAMMAGDMSLISMDTALQTRIAGANALALLRRHKLTETNDIELLRQFIGSASSHQTFLASVIIQEWALDTESRVSDPFSFSLGTSNPDVESLSTLLIDRIGSPPPSTYHEMAMVLQRIYSECSALLTAFNVEGKLSKDKIPSLPKRIDPLSNAPDVFSIETAHHAVTTQFDILSGKLSKNAIRNALPSLQERRNKVMGSVGYFSIMKEKYDVQVMAGIAGALVALKVMPPKFGPVIKNLMDGVKKEENEILQKRDAFWVAAFIQYTTSPFFTGRVNPSDKVVKNLFTFLCLDTSVTPVFSPTAQGATEGIITLLEERAAATVANARKKDIVEESEEQIASRMTRRGALETFKAMAKRFGSNLFEKVPKFWEGISGALLANFVDGVNIEQVDQHLTTNVQAGQDLIDALTSLRLIAPELDPVLHNRLYNLFSPIITALQSSFSVVRNAAAQCLAAMCDVMTDEGMKRVVDDVVPLVGDVKKDYSRQGAVEAIHRIIKILDLKALPYVLFLIVPILGRMSDPDEHVRLLSTSTFASLVKMVPLEAGIPDPPGFSADLLAKRDDERKFLMQLLDGSKAEQYQIPVEVKAELRQYQKDGVSWLAFLAKYQLHGILCDDMGLGKSLQSICIIASKHHERAERHKATKSIDSAHLPSLIICPPTLTGHWYHEILKFTPHLRPVQYVGSAFERTTLRRSLSSYDVVISSYESIRSDISEFSKFSFLYCVLDEGHIIKNTKTKLAAAVKQIKAQHRLLLSGTPIQNNVLELWSLFDFLMPGFLGNERTFNEKFSKPILADREGKATPKEREAAANALEALHKQVLPFLLRRLKEDVLNDLPPKIIQDYYCELSPVQQQLYDEFSRSKAAEEAGMEIENSASKEGQGHVFQSLQYLRKLCNHPALVLDGEPQRFKEIQKKIGGGPELHDLSHAPKMEALRQLLQDCGIGLPPDKLADDVTTHRVLIFCQLRPMLDIIEKDLFGTHMPTVSYMRLDGSTDPRKRHAIVQTFNADPRIDVLLLTTSVGGLGLNLTGADTVIFVDHDWNPMKDLQAMDRAHRLGQRKVVNVYRLITRGTLEEKIMGLQRFKLNIASSVVTQQNAGLGSMNTGEVLDLFKISAEGEPAKAKSAGVGAVSMSEMLEELDELPPEDEYAELSLSNFLGKYKYKHRYGYGALDVYAFFNHCDLLPCTWARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS37</accession>
    <name>A0ABR3BS37_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613946.1">
        <property type="nucleotide sequence ID" value="XM_066757562.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989916"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="310" mass="33729" checksum="5C29F4151F967421" modified="2025-10-08" version="1">MPPRLPFQPLALRIAPVIPHSGPSRLFATAPPTNPKPKGKSPASGDIPPLQRPLGTPIKPTSSPKSWQQKKDEMLDDDRAKAKRKALLHEAKQGYFHDYNQARTARGGKLWIAPNVLIREDKANYFPDITGKSLIGQNVHTTDVFKGKATLVTIISTRLSEEHVQSFVQPVLEDLEGHPDFQFLTINHQPNALKSLLVSFFTSSLKRIVPEHQWPTYLISAGTWSPIDIIEPLGLGNSLLGYVFLVDHNAKVRWAACGLATEDEVKSFRRAAAVLVGRMKGGVGAGPGADSKAGEKAVEGVVDPALSGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSQ1</accession>
    <name>A0ABR3BSQ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103987</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613870.1">
        <property type="nucleotide sequence ID" value="XM_066758468.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990843"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052639">
        <property type="entry name" value="TRAIP_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRAIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="494"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="208"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="701" mass="78285" checksum="F1076932F0405379" modified="2025-10-08" version="1">MGRRLEDASCAICIDSLFNKCDDLDDIIPIATCECGHVFHEPCLLEWFKSQSQAYLATAREAGIPGRHGSPTLSDAPVECPSCRAECFADPVTGNPIIYRLYITFDGRSSSVQPASSPLIREVDQQAKRREEEALRLARRAKALTEEVNGLGAESMEEEMGGLIKKTEGLVKDLELSAKAASGIKTYVGGLIVAVNKLCSVLEDHPVIHALQGRIFQLESTLKETNAEMKTIIPNEIRKAKEAEQAKADKKIKRIMDELEVIQRELEKEKVARRAGKKEMDERAKENEKKMLNLERREAKEKEDLQATLRERTKMLKMYQSKADSRKELKAKVQRLEAENARLQADLKASTNAPQSSRMISSRFLSPEAFDHQPNKWTSPQRDIKYDEIPSDNDDPSIQEILHFDRDLAGPHARLHASRAQLIPPTFADESSLLIDMPSFHDDSLRHATGLPGSPKRSGSRKDLDTRQHPTARTISFDLDEGLKRRKISKSKYFPVNSSSGFGSVGDMEEQVRGKERAREKEGVKEHRPRKRDRKGGDLFGSDAEEPGGEDKEVPDPQSRQNRINPFAASKRSTSSCAKLPPTSAILIPDSSPQRATFCPDSEPDHQLELDGNDDGQNSPGYKVVEPERVPLRIKEKEQAKDTSNASDKGKGKEMMRAGSVGKQKGSEQKSVVDWLGIRDQNGRPKAGTNLMLGRQIKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSV0</accession>
    <name>A0ABR3BSV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613903.1">
        <property type="nucleotide sequence ID" value="XM_066757519.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989873"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="70"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="871"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1563"/>
            <end position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1607" mass="174175" checksum="B309EC7FC593F20E" modified="2025-10-08" version="1">MAADPALASASKLAARAARFSNTLPGNRYKELEEARAKEVQQYHAQQRLVRDGKVELEDAVEMRGTCEKMCSDYEREFREWTREVHPFEATPDKRMDPAKAVAAYSRSDAGAGHGTAAILPSDLRTPQTLIRTLDYLFTSIMTLLPPSSSDLPPNNELAQRKALGYSAGFIRDRTRAIRKEFAMQSSWGHEQAIESFERIARWHILCLRELQEEEGTNNDMHIDSAELGRCFTSLRQHYNDRREESGLDMPCAHEPEFRAYMLIYDLTSKSISIPTSELPPSILSHPLVKIAWEIRRCAQRNFDSQKEGSKHNAELGMNNIRRFIKLLSSPKVPYLLACLVEIRLREMRRSALRAMTRAYPRLKTEPIRMNEKGQVVERRMVLVETLNKILGCMTPDSTPSAWDDVPTRSAAELDPDNESETICSRFNIPLFPPDNEGREKRGALINLGTPFDDNKDAPYTRRWALVSAKRGGKGFVQVVNSGSPLSSEGSLSVSAPLKITAQAQAPISAFGGGPGALSAFDFKKPLPSTTTPSSVKPVEGQTSTSAFSFGSGVGAGVGAGAGSVFGSTLTPAAAPSKPSPSAFNFGFSKPSSDSIAPPALTGASGVTLAPAPAGASLPLSMKTTSTSATPPLFSFSPSQPAKDTEKGKAVDVKAKGIPDFFSSATAPAAPASTSTAGLSNVPLFVPPAAMGESEVSVGGADAKSKEGEQKGKSGFSFVFGPTPPSTASELPSARTSGPATPAIDEKDRKRAAGDEGGKEDTKEKLGLFTFSADNAASSGSGIKEGAKDKPLFSFTATPGASVLGGASASATASSTAAPPLGANLNIGTSTLPAHTPPAFASSPVAGPASTTLAKETPNTIVRSRSRRDPSLLLSTSTPTSQSHPLSSSLSKSTSKVSLDAYHAKRLKRRQAIPSACEDLVTKVMEGMLRDYLTPDLEALIKQQLAEREYAARKACRSEMIKSWSEVLFRDHLLLGSTFTPSSGGRHRDGLVREIAKEAVLDEIRRRWRAREAGRWWKLWAKQKRERREGGERKRQEWLGGLKEMGLSASMGPLANVLGAKANGGGDEGLDVGIDSMDAALDSLQLDIEIIQAERDKDNFFAPSTFLTSIARYVAPQLSVAFTPATISLSDSASSSGLESTPLSPHQGHPVFITLLSKPSGGSSADKTVEEWLVSKFTPPNSSSQLEQVHDGEKEGGYTCGGVEFDMRVVDNGMLPKHSRDDGWIGLLVFEAPLKTADAKKASENVANAQDRMRLLVKILQNDGNRFVPGLIILSWGDETIDTLAERLQIQSEIASFSKKTVVSLGAADDLDQQFIKALEGLGEVETKEQGVLRLQDVAEGVLLHLKQFVDVSGILLSRRRNDAHLGWTCLKSGIELINSIPRLAREFIGARGLDNGNILDPIVLPEITSDAPSSNDKLVDQMAEYFENEIFGGIDELSLLVVRLSQAAQYGHALPIDSILQFLSLFVLGELQHHQLFARTFFVTETEMDQWQRDCLRQVIAKFDELVEKNIQLITSFAEPPPSSRVLVTSPFKTSSPTTISKVTNTTNTTTIPPGGKKRPRGEKDERAMLDREKKGKKESKATKAERLLRLMQKVERTLSERDNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSV5</accession>
    <name>A0ABR3BSV5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614228.1">
        <property type="nucleotide sequence ID" value="XM_066757844.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990202"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="155"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="827" mass="94479" checksum="F24E51626DD9AC95" modified="2025-10-08" version="1">MVSKGEDRQTKGDDGAAYGLNALSKFTLFRTKTRLYVVASTDSVHRVLKIDRTDSSTLNVVEDSTSYDETELHQLLRMVKDGNKSQGGLDKVMDFHGLVGFVQFTTCWYMILMTKRSEVGLLGGHYIYHCDDTTLYPIGPKVEKSAQETKMVNTFNLVDLSKNFYFSYSYDLTNTLQTNLTVSGNNRRWNTRFMWNHHLLSPAFNLEEPRGRSRWIIPLIHGFVDQAKIHVFSRTVYLTLIARRSRHYAGARFLTRGANEHGHVANEVETEQIVSEPLSTSFGQHDSSRPEKLISDFSAGYGGYTSFVQYRGSIPVMWHQESNQMTPRPPIEITIKDPFYTPAAKHFDDLLGRYGAPIYILNLIKSRESVPRESKLLFEYGQCVKYLNQFLPEGKKMEYIAWDMSQAAKSGQQDVIGVLEDICEESLQATNFFHGGPARNAVGAGPHRDHPLLQHGVLRVNCVDCLDRTNAAQFAIAKRAFGHQLYALGFLATPYLEFSCDAVDVLTEMYHDHGDTLAWQYTGSALVNRVDTYRRTKATQWSSHSRDILENIRRFYNNSMLDGDKQSAINLFLGVQPSIPTYDLKRPNYRQWYHPSHLKDPEPDDLAPINQVYAEYYKPDKLSEFNNMYAFNMNSTSRFHAKSRYDNVSSPFEPREQSSHYSVPNARRIASRWAAVADASGSPHQPSSSPDRTVGPKTIHFEPPPSAIELFIRSLYDPQDLPERILNYEFYTHYTESEGIDMVCEEQDLEMYHMVARMQEGKDEEFLHGTEMNMKLRMSDPPGDSGELAVESHQRLSKDMSTKDKQIIERYINMISVPLSTGGECIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTQ3</accession>
    <name>A0ABR3BTQ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614522.1">
        <property type="nucleotide sequence ID" value="XM_066757053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989365"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33055" checksum="EA9E6F8827D0F6DA" modified="2025-10-08" version="1">MPIHPHLHIFLPSSSPHVNLEARLYLPLTDNHVIPLTNQLATYTSPSLHYDKLEVEIVGAIREMGVERLITAAHPWGRMGGNMLDPVLYHLVSSTFAPAETADRALIPPLLPPPKTAILTYNVRGVGCSQGSQPWLGIGSDPADLAKVETVVADLLGNIRQVLRFGYSWGSLLVTLANPHPRLRHILIVSPPCKIFAGITVFSRRSFRMSLNDLLKIGVNVTMIYGTKDEFTSVDTFRAFGNDLPAVTTLQASGGMTNKDEGGTFEKLEIEEADHLYRRDNGEMLREKVGEWLGWPVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUK7</accession>
    <name>A0ABR3BUK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative tyrosine-protein phosphatase OCA1</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614810.1">
        <property type="nucleotide sequence ID" value="XM_066757341.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989662"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF8">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE OCA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="471" mass="51526" checksum="7F3981D83D189612" modified="2025-10-08" version="1">MVTPPKHLSIAAALPPHSHTLYRAAIPAPAHLPFLARLPLRAILLLHPHPLAPAHPLATWARTRSVRILWVRADAMGEERLGMAAAQVAHALKLILDPAHYPLYIADVDGTSHTTLVVACLRKLQGWHMDSIVDEISRAEPFALPPPPYPAWLWPVPPPAQPRPKARDRSASAPATPPSFNPLPFPHPLTARKHPTMRVVFPLPQSQSQSQSPGQQPQQQQPSLPLSPGPASASASTPACSDISRMSSMRHPREKTTLSSPAAQSSSPQLLPPPPQTESQTESQTESQTESQAIPVTTDTKDTKDDVGLGSPEQGVLGVAANLVHAGLHGLATVLAGTSPPSQLAENQVEREQPGKDEREQEQEYAQEQEYAQEQEHEYAHEHESDLRPKKEATEIPPSTTFSREPISSSKVAESSTSSVTVSDDQEDEHRLEDEEDEDEYDEEEEEEEEEEEEDIRAASQYISALDLAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUN5</accession>
    <name>A0ABR3BUN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NUC153 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614843.1">
        <property type="nucleotide sequence ID" value="XM_066757374.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989695"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="175"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="711"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="721"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="691"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="91396" checksum="4724D2E08DBB365D" modified="2025-10-08" version="1">MSDPRFASAKTDPRFRRPKQRNLKVEIDERFRDVLESEEFGGKNKGGAKVDKRGRPVTSSHKADQLKRFYRLKSPESAKDEVEGFVDYARGEGALYSSGSEDENEEDESEVEEKELEIGGKKKVRLPAMSESESESDDDHLDIDLSENEETTNFPPEADEIPSGDESEAEPVDPTKRIAVVNLDWDNMQAADLYAVFNSFLTRPAAKGEAKAPSALGKLLRVKIYPSEFGKERMAKEEQEGPGGGIFIGSKKKRDHKKERISIARKEENDDEEEKDNKEEDGEDGDEEEENEVSDEDFDLEDEGDTEEEDEESYDKPARKSNDKLHREIDGLEIISDIESEAGSEDIDMDQLRQYQLERLRYYYAIATFSSVAAAEYIMNECNGTEFEQTANMLDLSYVPEDMTFDEDSVKDEADKEPKAYKGNDFVTDALRHSKVKLTWDQDDPNRIKMTRRTLTREEIEEQDFQNLIAASGSEAGESDFDDEEDAESKSKKDKKKKMKERKEKLRNLLLAGGDDEDGVTDVWGKAGTAWANELEDIKSSAIKDKAKSASKAANKGEDLEITFRPGLSVARGDKEEENMTSLERYQLRMKEKKQRKKEKMELKAAARDRGDEEKTDGQDEFFGSDSSEEEEVQQPKPMSKPRSLEPTLPDEDDLAVIVGTNRPDSNFSMKDIIKTEKEAGKKRRRRKNKKGEQERDVELGPDGWKIDVKDDRFKALHEEPEFAIDPSNPHFVKTKAMQDLLAERTRRRDNQKKAEPEGRKSATGVKNVEQKEQDLDSLVASVKRKMDQNQHKAKRKRTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUP9</accession>
    <name>A0ABR3BUP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614846.1">
        <property type="nucleotide sequence ID" value="XM_066757377.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989698"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044617">
        <property type="entry name" value="TCHQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45374">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE TCHQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45374:SF1">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE TCHQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="286" mass="31452" checksum="0FA90736F112D066" modified="2025-10-08" version="1">MSGDKIQLYEFEGSVWSNVPKLALEEGGLKKDKDVKWISVDLPEGENFEPSYLKINPAGTVPTLVVGNDTFTDSISAVAEIVKIAPQKPKSKGVPSGGSIIEEIHSAAIDPNTTLLIATDDEDRKTKINGIPKGFLAGRQKTLDKLVKNPPEEFKEFLIKKQADNKQLLEFFIAEPDEQTRKAHYAQGQQLWNSVGNALRGFITEALTKNNQGPYVGGNEPSETDFHLITWLARTITNAGVEPGTNVDEAIKKLQAKTGGGAFDDSIKLYWKSWNARESFKTLGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUZ3</accession>
    <name>A0ABR3BUZ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614680.1">
        <property type="nucleotide sequence ID" value="XM_066757211.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989527"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="116" mass="13464" checksum="922D973FDAA970D8" modified="2025-10-08" version="1">MFPLGQASLQSELMRLKQAPALNPHYKMVIQYLDCLNRLADQLIPNSNLPAWLIEVQHLIKLLQKRVFSRMPLTPVERSALLNFAQYWKSMTRPPYNMGRPEAQIVMITLAEFAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV30</accession>
    <name>A0ABR3BV30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sodium/bile acid cotransporter 7-B/bile acid cotransporter 7-B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614974.1">
        <property type="nucleotide sequence ID" value="XM_066756197.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988501"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640:SF5">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 10 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="46912" checksum="2149B28B63F3AE93" modified="2025-10-08" version="1">MPSLATAESVNRHAAPITASAYAGGENVEKKRPWYHPSMILDFLIGNWFLIGIGVVIVLAWRFPHVAADGGVIRSQYSITYGVIAAIFLITGFTLSTPALFHQLANWRLHLFTQIFSFLFFSAIVFAIVNCVRASGNEAIDKYVLAGMVVMSVMPTTVASNITMTRSAGGSTEAATMEVCVGNLLGTFITPLLCEMFFSSSAWSYGVPIAKGGYEGSQGLKEIYRQLAKQLGLTLFVPLFVGQVILNIFPRQTRWVAATFRLPKVSTFLLLLLIWSVFSTQFQAGAFESISHISVIFLCFVNFGLYVVFTGICLYFTRLPFLPENFGDRPSSGVSRRDLEGQAIDGGVHAGVNTEEETEDGGRRTMKKPFWERFVSGLRFDKKEATAICFCAAAKGMVVGSPTLSILYGGFPARERAILSIPLVLYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVE4</accession>
    <name>A0ABR3BVE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_102590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614604.1">
        <property type="nucleotide sequence ID" value="XM_066757135.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989447"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="11">
        <location>
            <begin position="159"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="360"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0250417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="408" mass="46221" checksum="869268553B82EBBF" modified="2025-10-08" version="1">MSMSRPPFPAGWASVRMDPRNLSLANTLPVGQAFLWHRLPLPATAPPFEEYSRAIHSPPRVVCLRQSPTHIYYTAVYPPGSVAEPDPSFQLTRQWLEDYFQLVKYPDLETMYLDWRRRDPELFGKVHVNDRATGPTTSSALTGSFITSTNNHIPRITSLLHKFSQSFTEPVLTLKHPSNGNLIPYHLFPAPHQIPTRLEKSLRDLGFGYRAPFIEASLLLLRNKFGDKEGNIEAGLMGWRDEDVDIVRENLTALKGVGRKVADCVMLMCLDKPSLIPIDTHVANIAARHPAFPSRLKNKPMSKQIYEETQEFLLSRWGPMGGWCQAVLFAADLPQSQGKTKVKTKVESVLKTVVKTETSLDSVDSMRRKRREDEVEKPPALKRTRSATKQAQHVPMGVDIKYDEKTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVU0</accession>
    <name>A0ABR3BVU0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615217.1">
        <property type="nucleotide sequence ID" value="XM_066756440.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988747"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="532" mass="59648" checksum="2C504B3EAD4EF849" modified="2025-10-08" version="1">MSSSLTSTSSDDQTSSHSPLGSPCRHSRKDRSKCAVCQTPVNHCLKKARAFGRDWITFIVLHGCINPECSATYCTACAMVCTLHETRSKRMPICRVCRKPLYFRSLPKRVQFYDEAFMTHSIINTPIESRQSTREAYLFLISLVVERYRTLRSGSAFDIDDFYVWMMDTHYAFTKQPVNWASVDRVALTLVWISSFAGKTPVLRHDLIDTRLRFEDVWSDPGLRHAATLEGLLALHLHREGSQIILKLQTARRTIRAKEPQHPQIWTISERIHRIAVHHVTKARQLYVYCYTQTYAPLSATRPRINVNIPPNAGINELLRILEGLNPMIEDFDWDYMLHHPTVSAVWPHSDFRVAPGLGQPVPQAVKLLVGSRDSVPFPKQPAQPSSSSQTLGFSGSIAPPIATSLDPPPPRPTKNQSTPNTYEITQMLPLAQNTQALLQVTGANQPALPLSSHPHTSYLEGVAGDDYMDVDEEVRPSESQLRVSSQQPQMSSSTQSPASNPGKTKLLNEAPTKAYAPNESPRSFYSHLEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVU4</accession>
    <name>A0ABR3BVU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615240.1">
        <property type="nucleotide sequence ID" value="XM_066756463.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988770"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7204" checksum="81623CAFAF6D2137" modified="2025-10-08" version="1">MAEPIQGGQTAGTAGTAGATGQQDALDKGVDAALNRAGHGQSHSTTEKISDGIRNVFKKATGKDVPIKDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW19</accession>
    <name>A0ABR3BW19_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615207.1">
        <property type="nucleotide sequence ID" value="XM_066756430.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988737"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="125" mass="13890" checksum="50A2B5C7041EF843" modified="2025-10-08" version="1">MGTMGTSAFEREEMGVVGRGDALSQSQNLSPSQRKNIEGPALPKDEHPIRNLRTQTLQHTTFYPWPLSYYDPQLTFSRSCYRFKNIEGSKRPGTDRPKGSISLSKGSPLDAPKNSCAMPIRCGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW41</accession>
    <name>A0ABR3BW41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615322.1">
        <property type="nucleotide sequence ID" value="XM_066756545.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988852"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="BSD" evidence="4">
        <location>
            <begin position="423"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="811" mass="89681" checksum="A7DBE2A5F4AC3570" modified="2025-10-08" version="1">MVGRWADLACTNEHGSISVQQVFEVFGSFELMIPCFQEILEDIAHISNNQFGHFAITKLVSYPNFYKQTCEAIINSYPPVATTHHGVNLAKIALTEGGRASFVKYVEAICRQDDGRTPGIVTIATSSIGKAHLTFVMSCLTPSEHVRVRSTCRTYSTTLRNCQSGNDLLRALGIMHSTSTKHRNAGISNANPRQYRIWVPKVKDAMDRQSQAMNRAINMLASKPGKERVSLKILFKENVPPGGLLFVFTNASSREDDRKAVQDILIPFVAVNKNPTASTPDTPGSATTPNTPSAATVAAMSDVAKGKRKMNEMTPMGLSAASAESSPLPPAVRSQRRKYNTLRQRVLEKNDALRMLHRDLVLGRQITEEEFWEGREALIQAEEMAYAQKPGRPSRLLDDRFDLDAGRRGKTTGGTGVGIKQADNGPVILKLSKELTREIFEEFPVVQDAYARYVPGISETEFWSRYFTSQLWERHRASVRKSANDEISRKKDDIFDQYLEEPDWNLQPRQPMPDRDGVERYLDLAATEEDHGEASSIRDVTMQAGRERSALPLIRRFNDHSKKLLRAASAGQTIRNSAYGGDIDIYEEINLEDLHDPSTTPAIILDVENAAALDEGDDKLAPTGILLGHSDSELLAMATESASILRDSAPDFSSVCLANPGPFIDDDESRRNPAYEAFAKQRDGQAAALAAVRDMWSRANAENAVLPAFPEMLFEQIRSCHNSATEFLRQYWSAILPSVPGALGGQTPGAKDAKAAKMASYLKNTSTKIEAIVQTAQITGFDPERVRKVLAPTLGAVEVALERERKRVKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWA7</accession>
    <name>A0ABR3BWA7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615377.1">
        <property type="nucleotide sequence ID" value="XM_066756600.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988907"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="318"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="537"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="809" mass="91601" checksum="B9E3CE7275EB5AA0" modified="2025-10-08" version="1">MATKSKCNYRWESRKLLIKDELPQGNGSGEYAYQTTPQFWKECPAFAAGEPAYASVLLLSPTGEKTLDHPECRPMCLLTTRPLPLYEKYNMVEVNLGVGEQPTHRGCMKAINAGPLESLDDVQLGQTLRFTERLMRAELQRPIKAYLHHIKWLLLPLKYGYRQLGPVALEDIAWEQVKAIADGPLTVPFTFRNQDDLGAQCFDAMATANSEMARRSYITAIRQDLNPSSSHPEQPEKTILQVIQGETSTFPRLTQPNQPILQVETACLAKNGSYITTFTTPSAQRPKQYLIPEYENRHCIPASIFRTLTVFPFFIHQLEFMLIAYEMSTKLFGSLLHPELAIQALTAPSSLNVTPWTYERLEILGDTLLKFFITIHVYLHGRGSNSREDPLKVWQDRHKLVSNRTLTANAIKLGLVDHVRDKRLKVKDWIPRDWELDVSQGQTVPKKAVQTSHDGPETRRLGDKLLADIVEAIIGASYGTDKDFDNVISTLIRLNVPLDLFTTWDEIKHVLPSTDECDDTEEDGVDAEKMDSLSSFEILGYKFKSKKRYNDVISMSNQPDARRIRENYKMLGNAVLDLHVIELLLAKYPEEGPGSLSNMKTFRTTEGLRCALATELGLQDLLKDGDERAERELGRATYFMRDAKAQADAAGVSEDEQGGIHYWDNVAVNHFTGSVIEVIYGAIFQDSGFSLEHTQRIFDDHIVPFTEKYCKGPSATDLHPKGLLTRWMQAKGCAYWKLDAVGPKLCEGVVTCHDQDVARCKAFTTHMAVRNVCEEAIKRLRDENRIKDICDCPSFKEVIPEDKTFGKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWE1</accession>
    <name>A0ABR3BWE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614949.1">
        <property type="nucleotide sequence ID" value="XM_066757480.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989834"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF9">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="242" mass="26085" checksum="0B24081BDF3F27BA" modified="2025-10-08" version="1">MIGCFSSLPSAWTARIVASCGWDYVIIDCEHGNHDDSDMHDTVNVIASENVSPIVRLRAGEYGLIKRALDCGAHGIMAPMVNTPEEARNIVKWSKFPPMGIRGQGSSFSAMASGLTTPQYVSLANKTILTIVQIETPEAVSNAEKIASIEGVDALFIGPNDLALSLLGYVPARWDEPEFLDALEKVRLAANKYGKYAGILARNGAHAKELSEKWTMIGLGSDVRALQTAMKATVAASRSEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWY1</accession>
    <name>A0ABR3BWY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615622.1">
        <property type="nucleotide sequence ID" value="XM_066756845.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989153"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="5">
        <location>
            <begin position="74"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="285" mass="31752" checksum="11AD940F9B34408D" modified="2025-10-08" version="1">MSRHPPFIDVEASRPEFDRDFVPVVTKTPNPSFKPGQGLNDLPYAKEFQPNEGKWRSIIPEEQAGSDVYKMMISGITPRPIAFVSSMGSDGNANLAPMSYFAVVSHNPPTIMISVAAGKLIDGLKDTSHNIKETSEFCVSIISEPFLEAANFTSIDAPNNVDEWVLSGLTQRPSETVKPPHVAESAFSMECEVLHWYDLIGDEGQPTQAVILGKIKRFQVKEFVLDPEDQMKVLTERLRPMSRLGGISYARSTQVVEIPRPVWDQVKNTPEVKEALEQGPRKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXE7</accession>
    <name>A0ABR3BXE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615260.1">
        <property type="nucleotide sequence ID" value="XM_066756483.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988790"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="268" mass="27573" checksum="F65B575AD1FD2B9B" modified="2025-10-08" version="1">MGLFGSSDPVKETEKALAREAKAEEKNIKQSVKSLNQVERAEAKAAKAEQQAEKHHLKASKFEEKTAGLLNKASSKHEEAYHKENIAASEVTQKQHAHSTLTHTVEQKKAQLDALQKKHQVNEQSRQSKLHEIAGPEASSGNSAGVTSQHHPSSQTDSQAAGTAVGGQNSGAGAPTTGGAGRNIGTAGHQQPGNAAGGALGHSQQGVPAGNLPAQGGGHGMTEGGISQGFNNAQQTNVNPNPGYGGITGSGNQGMSQGGKVTEAVHRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXF4</accession>
    <name>A0ABR3BXF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102709</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614718.1">
        <property type="nucleotide sequence ID" value="XM_066757249.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989565"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="61"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="309"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="895"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="848"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1136"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1196"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="934"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="160"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1272" mass="141336" checksum="EC34DF00BFC40413" modified="2025-10-08" version="1">MSLSRRQSIASSSPLSPSAITTPNSSAGRHSFGYPRARLSSDASSISAAAKETLNTLENRNVKVVLRIRPSDPDDPSVPPRFRSVLVHPISKSDIRVDVDPAALAGHGTGIGSGGKKYSSFSFDHVLGESAQQTDLYQCTAGESVEEFMKGHNVTFLAYGQTSSGKSYSMGTTGDSIDYSGTEFTPRTGLIPRIVQTIFERAEDNRQKYGPGASWEARLSFLELYNEEIIDLLSGAGISISIREERDGRIVWSGVREVSVRSLSDVMELLQEGSTRRKTGETTMNATSSRSHAIFSITLVQKRSSSALPVLSASGSETPTRQLRRPSSMIGLPGSSLRSPIPSNSRGGPPSSFSRMTPSRPQSAFNPLASPEKFTVISSKFNMVDLAGSERLKRTAAQGDRMKEGISINVGLLALGNVISALSDPVKSRGHIPYRDSKLTRMLQDSIGGNALTTMIACVSPIEVNIGETLNTIKYASRARNIRNSAKVNQVEAGWDDVEYLQNTVLKLRKQLVALEAGGKVGMSEDDLKQSEKLTRKLAELQREHTELYDRYLGKCHENMCLSSELKSPSPDDGDALTRSKEMVDPVILEYEKVVFALNQQLDDLRAEITLLNEISEEQSRHLQDARESQLESETYLAELRARMVKLADRNASNEAFIQDLEAKLEAYADREDTHTLVVTELKKEIVKLCENGASSSKNVSELEARLATSETLRKDLAALIEKSERDATVHEKAFHDLETHMIHLEAADHNKRLLEELAQKNCKITELEDRLKEKVHCQFKQRGSELYEAVGAEQSMQKELDSKFDLSDISASSNGRPVTPRCERSDASASTFVSDDAKAMLGNGVPLNQADRERSQLEQLKKELEELSAKYSDSKARIADLTAKLSEASHARDVTDDMVEVSQLTTEKLSRTDNEEEDGVSTGDFPESDSTLDSDNKQTLMRRTSLPLLDRSGMSVEQGFRGGRGYSNSKRNRLQSLSLELSSARSSATSPRAMWSLPVTKFHLSSPPMAPARPAESSLSSQSMEAELRFIHRIIDERDKELRDKEAYILHLETQLETAIAHDILSHKPSAKINVEAGVTEAKQDFISRKMVESRLLEDEEQQRQLKMKADQALFELSRVRDECALERQNGGKQISELTERNGRLERVKVELEKVNAELMKVNAELATAVSGREAEREKEKIKEITKLQEEKVEVNNLALELGECQKMANNLRAQLDEARQEMTRMSIISREEQSRHDDLLQAAQAQVASLKVQLERAVDKKVAEKRLRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXX2</accession>
    <name>A0ABR3BXX2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615696.1">
        <property type="nucleotide sequence ID" value="XM_066756919.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989227"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="153" mass="16716" checksum="E9A569EC871461C7" modified="2025-10-08" version="1">MSIPRFYHSAASGTSSIASNLSRPVPFTGQHSSDPRYYYNPQSSNTFFISPSSTPSNPYTTFDSAQTSFASPLNSTTPTQPRSASTNSRSGPDTIHPSDPADDPPFSQPDRPPWASEKSWQPKGRPMSGLDELDRQTILNSLFNNIPPPVEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BY04</accession>
    <name>A0ABR3BY04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101802</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615131.1">
        <property type="nucleotide sequence ID" value="XM_066756354.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988660"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02867">
        <property type="entry name" value="PseudoU_synth_TruB_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="68"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA pseudouridylate synthase B C-terminal" evidence="8">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0252411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="446" mass="49259" checksum="30F118C7A40830FA" modified="2025-10-08" version="1">MPKALPTPTLPLNGLFPIAKPSGKSSMRVIDRITPLLLDSKLFDDPVKRAQPQMKGKRKKNLTQFGLKIGQGGTLDPLADGVLVLGVNRGTKHLNQFLECSKEYESIGLIGATTTSMDADDPVLSTAAWEHITREDVEKVLDRFRGEIMQVPPIFSALKMDGKPLYEYARESKPLPRPIPARKCQVSIELIDFTPASVAPGDGGHDYHWPEKRLTSEEKETFRKLTQIVHNAQTGPVEAAEASGNKDQVEEEKSKVVEPLVPDLDAPEYPEISPKTGLRPPTFTVRMTVSSGTYVRSIVNDIGLALGCGAHVVKLTRTRQGEFSLHGDEEALSATSVSAPTEGEEASVNSVNENNREVPGPSGGSIPWAVWERALAERDEMIKREKLEKEEAIMAGMSAEEIHQVYNPEAIKQRRWEGGWKEWEVEVLKRFKPVPVPINGGHGFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BY65</accession>
    <name>A0ABR3BY65_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615191.1">
        <property type="nucleotide sequence ID" value="XM_066756414.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988721"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="558" mass="61718" checksum="7F7DED00408536C7" modified="2025-10-08" version="1">MRPPPNRLPDSPLAAHLSSFFTPPSKTDSFQSRELLKTLPESSHNGRHGGSSKDEAPSSFPHNKPSHPYIGPSVPTLPSKNSSQSALFQPLLAQEIFVQNKGRKIMTASDRIMKAIEDLNDRLASVQEDVIMLKSDSRHTRDQLHDLQLGQRLLPVRDEIADEIMNILTPVIQDSLQSITHCLDNAMSSIAQNITGTFFPRLDAMTCGLEKVPQTSKRDTGMNFEHSNSLLQEQNKCMSDVIKKLDDSLEAQRHGSQVLNDCKKFFAQFERLIGSSMNPNDRYIQNSLQELHVKVNQLSAPFQSSEYAELKKQATHLVASSASITRVFDELRLILSNQTHLKMLVEHLLRTCNSSNLQNLPYRHEPLSSTSQHLSLDYLSKAFLSETSSTQLLSTQSGTIQSNCLDDSPLRSDGLADCFGSESCIAGPVNFPCNTSMREITSLNPHSMYAVNQNKPSSDLGVSATVSPKLCSASKAGPSSLINAQTHHRQTRQSCKSASHSPPYAVQSSGIPDRQESVLQPLEAKERDISNAVPTEARVSKGKKRTWDFSSDEEADET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYM5</accession>
    <name>A0ABR3BYM5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100862</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615711.1">
        <property type="nucleotide sequence ID" value="XM_066755425.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987720"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0253490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="841" mass="93947" checksum="A3172076C4F7E332" modified="2025-10-08" version="1">MAIRSDQQASAEIQTGNGHENVGMRLPHTPGQQHLESVPIAATSRAPASSSSIKIAACLACRAIKGKCETPDGVGPCVRCARRRQQCERPIIHRSGRPKGSKNRHSSLERAFKVIERGVHQSPAQSRKRPRLDRDGQDNSEGSHIYDQSGLAQSPITQPATSPQQPPYRRLPESSFCPAPFDFPALDAVEPQRPSSSTASLSITPYTNQQQPVIPMSARSYDSHQSSHPGGEMTREHDDGLSNPVRLLAEAAEEIGASEQSGHFSERTIQAATTQEPILPPEYNLPETLYAMLTDGEMDPISNTSGLSPEYLAQGLEILLSDGARRKLSDEDRVFFNPPLKEVKRDIGDEYCPLALALLTPREVKAFFATFYLKLHPMLPVLDPVVHTPEFVQSRSAFLFTAICAHGASLTAGAEEATKRLRIHTQRLADQISPRGFISVEIVKAFLIWISWLPSSVPFQEERLWHETKYAINMGLELELSKPLPSDLRDLRKDPSWTACLEGISMDDWDVVERIIRSRQRLWIHLFLWDSSLNLAFGKATRFTQDHLIRDETWCFHRLATKGDAVTTACVNLRRLSVRLSDMLRLELHIRANMTSEWVAERIDEVLNPWRAFWSQHCDGSAYLELVFRHTRLWTLSYALQALTWRSGLRAAAGFEGIMGKAHLLSSYEFVTLTYGQGFPNTMGPMLSFEALLAIRLLPQDAGTTLAFRARLFGVLSQLSLLLEQVGTTPSHRLGTAAVYGRHLQVYIRCRVIDLCVNHHQYETGQLHGHGSDHTAASSGSQAPLMREAEASINQLFSSDWISPTDQAQANMTLDGINTLTFFDTTAGWTDDFFRLFGKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYU8</accession>
    <name>A0ABR3BYU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615713.1">
        <property type="nucleotide sequence ID" value="XM_066755427.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987722"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06152">
        <property type="entry name" value="YjgF_YER057c_UK114_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0253492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="139" mass="15839" checksum="9B2DEDDC2F11D7EC" modified="2025-10-08" version="1">MSDLTYYNYKGFGEKAQGSHYYSQAVRVGDTIQCSGQGGWANEGKFEFYKEINAQIDQAFENVQSALTAAGGKGWDQVFRVNSYHVPLNNEALEAMVRNFRKWMPNHQPLWTCVGVTRLGEDDMRVEIEVQAYDPVKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ23</accession>
    <name>A0ABR3BZ23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101911</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615239.1">
        <property type="nucleotide sequence ID" value="XM_066756462.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988769"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="436"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="625"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1077" mass="122315" checksum="DE7FAE83296674AE" modified="2025-10-08" version="1">MDLENFISDNVVRILGSSDSATVDYVHSLAMSSKTPGDLYNSLLATGMASTPETQAFAAQVHSLVPRKTKTKAPKADKTTSSQRFALLMDDDAEGSGSRKEKKKKKEKEGSKGGERDVVGVKKARHARKRDTEGNWDSDEEDQETKRTRTRSPLAPDGGDDQAELPLEQQPGETEEERLERERLEDLRERDEFAERMKEKDRDRTKRIVEDRTSKALGGIEATRRANLMDDPAAREAAIADLRNRSRQEYLSKRELQQLDLLKMEVEDEKILFRNQKLSRKEERELERKKELIRLMEERKKIDDGTNGYMLPDDYITEQGRLDQKKKKDALYKRYEESKPVEGQFVTDVDQWEAAQQERTDLTTGALDKEILVEDYDYVFDESQEIKFLKEGKMDGTLTAEAQALLDQVDKLEKNAQSIQDTRKSLPIYEFRDELLEAVAEHQVLIVVAETGSGKTTQLPQYLYEAGYCKNGMKVGCTQPRRVAAMSVAARVAEEMGVRLGQEVGYSIRFEDMTSDKTVLKYMTDGMLLREFLTDPELSTYSALVIDEAHERTLSTDILFGLVKDIARFRPDLRLLISSATLNAQKFADFFDQAPIFDVPGRRFPVDMFYTQQPEANYMHAAVTTILQIHTTQPKGDILLFLTGQDEIEAAEESLKETMYALGDKVPELIIAPIYANLPSEMQSKIFEPTPEGARKVVLATNIAETSITIDGVVYVIDPGFVKQNNYNPKTGMSSLVVEPISRASAQQRAGRAGRVGPGKAFRLYTKWAFKNELLQDTIPEIQRTNLSMVVLMLKSLGINDVLNFDFLDKPPADTIIRSFELLYALGALNHKGELTRLGRRMAEFPVDPMLSKAIINSENFKCTHEVLTIISMLQESGSLLYRPKDKRVHADKAHKNFIKPGGDHFTLLNIFEQWAESNYSQQFCYENFVQFKSLCRVRDIRDQLAQLCDRVEVVIESTPNDVVPVQKAITAGYFYNTARIDRGGGYRTTKNNHSVYLHPSSCLIGMQPPPRFILYYELVLTSKEYMRQCMPIEGSWLSELAPHYFNKSEIDQLMGSASKVKMPKRIEQPKVGPVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZC6</accession>
    <name>A0ABR3BZC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Eukaryotic translation initiation factor 4E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615329.1">
        <property type="nucleotide sequence ID" value="XM_066756552.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988859"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33079" checksum="786C3DAB404D943E" modified="2025-10-08" version="1">MSSTAIPPAAVSANNNALNSALAAEQISSPASPIDKPEDEKKQLEEGEIEENPSEGDSQTKTIFDDASKFNVKHPLFSTWTLYFDSPQSKSLPKTPQTTPAMPQGSHGWMADIRKVVSFDSVEEFWGLYNNIIPPSQLPGKANYYLFKNGIIPAWEDSQNKNGGKWSIQVPKNSESKGSIDRMWLYTMLAAIGETFETPSTDSENAPSPTQSDLITGVIVSPRPAFYRISIWTREASDVNVPDTDAIKARLLNIGKHFKTSVLGYELEQKLTEGGFQTELTFDAHKDSEKKVNKNKFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZH6</accession>
    <name>A0ABR3BZH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615767.1">
        <property type="nucleotide sequence ID" value="XM_066755481.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987777"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="141" mass="15701" checksum="D4B2E409D9E8C9A2" modified="2025-10-08" version="1">MSGNNAEYREAFALFDKRGTGQVPRESLGELLRSLGQNPTQAEVAELEKTVGATFNYDEFLTVLNRPDGWKPAGTADEFIKGFQVFDKAGNGFIGAGELRYVLTQLGEKMTDEEVDELLKGFPVQDGQINYHSFVRSILFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZI1</accession>
    <name>A0ABR3BZI1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616017.1">
        <property type="nucleotide sequence ID" value="XM_066755731.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988031"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047049393" evidence="1">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="110" mass="12305" checksum="3B399EC01C04B7E2" modified="2025-10-08" version="1">MMFTLNAFATFTILLSFTSFVSATDYRLLVNKPSCQTMDQFKFNFETLCPVFQTSNTTEYNGGLYFRPGNYQGQNTDTQALVFCTYVNCTDNSIYPVTSELVTSLGGSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZX7</accession>
    <name>A0ABR3BZX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616164.1">
        <property type="nucleotide sequence ID" value="XM_066755878.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988179"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="635"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="695"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="491"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="768" mass="82946" checksum="5C56E52B12B1BBC8" modified="2025-10-08" version="1">MSTPAMETHAPQTNPTPAIVSEKVPLNTQALPKIVFAGRTGRILCVADIRGDYHELNRLIREHDATAVIHTGDFGFMTAESVDRMNDKILRHLIQYSPLLPPAARTQLLAIPSSAGRSALINQLNNSSVHFPLSQFPHLLSGAINFPVPVFTTWGLVEDVNVIEKFRTGEYGVQNLAILDEATSRLVEVGGVKLRLLGLGGTVADHKLFDYGAFCSKISKTTEQPTGEGHGSIAGAQGTMWTTALQIGELIDTAQRTFSPDETRLFVSTTPTSRNGLMTLVSNAIKADLTISCGLHFRYPVSYNEYSIHPDFESYRRKLQQAKDDFKGLFDQVRDRVFGSLDDKQTALFHKSLSAIDNVPIADDGMWANTWHWSLSDAGFGNMLLSITDSRVSAETKSSGVNFAHRTGKGPALPTGTTIPSAPSGLNSVKSFSSRPGPGPIGARPPPTQGIPSAHGAPGAFASQGRPPIRPNMGPGFSTRPPSGPRNTRQFGSGPASSMGGMSQSQMFAQAQAQAAVSGKTAAAASLANGKKDEKNEKPEGDKGVNEEEKKEKLAANGNAIPEKIKYTDKKEEKKDVKPIEKSEGKEKSEGENPWEEDKEEKKGSNPWADEVADEGEKKDEDKGEFTEDAKPKRYSLYIKGLPTPTTEEELKAVVGESGQKAIQVKIIFDQFTKQQKDFGYLDFDSEEVMNEALKSSTGTIRDTPVNVSISKPTVPRYNSRQFGGPGGRGRGSFRGRGRGFGSGPRRERGEREGSGSGNATAGGEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZX9</accession>
    <name>A0ABR3BZX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616161.1">
        <property type="nucleotide sequence ID" value="XM_066755875.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988176"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="54"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="657"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0253940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="678" mass="74160" checksum="141D6EDBB342BD65" modified="2025-10-08" version="1">MPAAVRERSPSSPSGRATKKSRNNTERAVLSSINHPSAEQVAAYREKYVNAAPFKHAVLSDLLSDELLEGVVEESKKFGMRGEEGSLPGWGWEQKETDIYKIQQTPDLSSLSPEHLPDETLEALPLLTRLKDALYSQEFRNLVRQVTGCGPLSGTKTDLSAALYNKGSHLLLHDDSISTRLISYILYLPYSIEDAPESKNVALQRSTNGKFLKGWDPAWGGSLELFPVEAGQEVGPPSVKRFAKVSATWGQIVFFEVQPGRSYHSVEEVVIDEGRRRFSVSGWFHRPVEGEEGYAPIDKEKEQMQLSSLAQITAAPSAPFTSYNTTPPAGLKPSDIAFLSNYLSPSYLTAATLERLSGQFVEASEIVLYNFLQPELAAKLKAETEGVDKKDQASFEGVIPPQELGEGDGWIIQGPSSKHRYLSLTSLTTSTPIVQSIHNVLFPSEAFRAWLSVVSSLAPTGHRNEARRFRNGLDYTLANGEGKDGDARLDVSLGMTWWADVPAGSDQEDALVENGGWEAYLAAPDEDEDPTVYQSSMAKKAVKEHSQEPKEPNGKKSEEKPKPHANGSSEKKDGPSISIGGQELEFDPDQFSPSDFDSDSEVDDEDDGPLLTQPVAFNRLLLVLRDPGVMKFVKYLGANAPGSRWDVTGEFEVGVLEEEPAEEGAPEAEGSGEVKADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZY5</accession>
    <name>A0ABR3BZY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616169.1">
        <property type="nucleotide sequence ID" value="XM_066755883.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988184"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF21">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="378"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="509"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="687"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="734"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0253948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="924" mass="97712" checksum="76509A22E8DC61D7" modified="2025-10-08" version="1">MPLSEARYLAALPAQSKDAAPDSLYQGAYGAVYRGKHVATGHIVALKIINLDTEDDDVADIQKEISLLQQLMLGGSTSGGPPPNVIKYYGSLMQGPRVWIIMEYAEGGSIRTLSRAQPLKELHICLVVREVLLALAFLHKNGVIHRDIKAANILLTTQPHRILLCDFGVAALLQSSTSKRSTFVGTPYWMAPEVVTEGRMYDAKADIWSLGITLLEMAYGEPPMSGQPAARAVMLLGDKRMRAPRLEGDHWSKEMRDFVVGCLNEEPADRLSAEELSKSKWIKQQSKTPLTAMNDLIARYQAWKESGGQRQSLAAGVGASVDDDDDHHHHPDGHPADGDWAFDHKTVRSRASMLLGKEQSGDTARPAPAPQSLRRLFHDESSTDPDPFQSFAHQQPPTPQTTEGSSTIKQTGRFPSPEHSDLPPLDDSSSPPQTPSKKNEFDGQTIRQARLGRDGRSPTPLMITTDYPPSSSNTPSAMPTATYHPVQTSQEPTPIARTDHTNTTTAAAAAAAVPSPRRIQNKMSLDNLSLTPTSKTQPAVEERSKSSGGMRRPSASDARDGLRGFQFPLMTKSGPGPSTTTASAASSSSTQAPSSDKLFPPSLNRNHSASPTFPFAEPLTTTTTTTTTSPTGTSSPGFGGIALGPRPPMMRQASVAVMEGRAASQSQSQAQAQALALALAQTQAQQLQQQHQQQQHQQQGPASPPTPKKTVALAVPSPIGLGRPGMSASTATAAGGGSGVGEGGQGMMIRSRSGSKAEDGHPVGLRDLLKFSPAVPDMPDLLPPSPSVATTPHKFFPSPSPLAQTTQAHAEPPSAAAVAAAISSLPIPAFASAPMSAAASQTSLASTGTIPASAPPGLATQPAAFASVNAKLGPLIRPLDLSTLESDDVFDELGRMVDDMQSWLGCVESGLEELLATGVDSHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C094</accession>
    <name>A0ABR3C094_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphogluconolactonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616274.1">
        <property type="nucleotide sequence ID" value="XM_066755988.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988290"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF7">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0254053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="40498" checksum="B648B53D600173C9" modified="2025-10-08" version="1">MSSYTLLVGGYRPNYSLISFDPSSAQLKVISDCPAPENASWVEPASLSEVKDGSRIFYSLSESQGKAVSLKVDGEEVAVTSERDTHGGACHVHVMKDRSGIAVANYLGGSIIFFPITSDFTLSSSSASPLLKFPLIYEVQQQTAPNPERQDTAHCHQIIEGNEGTLYVPDLGNDRVWVVWREGESGLSVKGWCQAPSGSGPRHACISNDGKHLYVLTELSNSLLTFPLSDPTYPIIPHPDSQLNVIPPSVPEEYHKYMNAAELVAHPVHPVLYASNRLEIDLSESTKGAFRSSVTGDAVAIATLTSDGKLDNVQHVRTGCNAVRAMQLSPDGKFVALAGQNGGGMEIWTVGDDGKTWALICRDEKLEGITDVAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0R9</accession>
    <name>A0ABR3C0R9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor SUI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616440.1">
        <property type="nucleotide sequence ID" value="XM_066756154.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988458"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="59"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0254219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="159" mass="17061" checksum="0DF5462CE0F85F81" modified="2025-10-08" version="1">MSTTVTQSKVDATTKKTKAPAATAGVENLGPAFDPFAPVNDLNDTPSIEKAVGSKNDKIHIRLQQRNGRKTLTTVQGIPSKYNHSKILKAMKKEFACNGTVVKPEVDSGEEDSPAPVAKNHGDVLQLQGDQRVAAKQFLIDSGIVAQKEAKDLIVVHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0U8</accession>
    <name>A0ABR3C0U8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616469.1">
        <property type="nucleotide sequence ID" value="XM_066756183.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988487"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0254248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="339" mass="39247" checksum="5D6F04D1C527D987" modified="2025-10-08" version="1">MLLVVLPRTGSHSDSLAAYHTVSLPLQLPLLPHNRSLVEMHSSLKPSPTDRSTRRQFAALDTVRDIILDHLCNIAPTTTILVNKHCYKRTVPVLYGKALLSPYLLYGITCGDKEQYLRTANALQHVRALEIDDMRCMAFLREFSIPSLTDSALFPIEPQDILGGVERLEMPWTVLHFRDWDSYRYEYAFKSLLKYDYGPVATVRVIFRLTEDITYKDERKWQDEFGSSVSEIIVKASQRRLRNHGKFADDPSRWPDSITKLEIYTPESQRIVGLVRKLVTKQDDKVWEYIQRYREIKDLKDARKRISTGWVGRYKGSDHSSCYGGKESCRKLCISPFHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C240</accession>
    <name>A0ABR3C240_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616057.1">
        <property type="nucleotide sequence ID" value="XM_066755771.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988072"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="433"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0253836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="67711" checksum="1D80C4081D7EE53A" modified="2025-10-08" version="1">MSSEGTPSPSPVVLYDIERSSAPNSSPDIPGILRAKRHSVFPRPRLHLPRPLTVALTCLSIAASALQANGVYCWGTYGPVVTTIRQLDATQAQTIVVGGIVGVYLMAAPLGSLTDRYGPRIGVGYLSFSAILAASTPETPLLYIWLTAAYFLVGAATVGSYFACLTCASLSFPTHPTLSLSVPLSLMGLSSLALSSFSSLRIFISPSTGDLDPVKFLFFLGLLSPSVNLFGALFMRIIQPTTPPPLEQDIQTTAQDEGTGPNLPIDQFLHLSEHSPLLIGGPEAARPALEETYASIRDGDEVEDASKPDHLHHMDGATWPGAGQWGVRDLIADWQGFWIFGILVALVIGPGEMTIASIGSILTSLLPSPTSLLPSPTSLLTTPFSHLSTHHAASDTNPLKQRNTQVFLISLSSTLFRLLTGLLADYLSPPPTAVPNPAYHPDQDDPFAPTPAEAEAVDDTNDDHAPAGAGGESAANGDRHGDRERAHPQPPHLWKQIKKVKMSRAAMTATCALLLGAVYVFGAAGLQGKQGQGGERLWVLSIGVGAMYGALFTLTPAIVSLHFGPTNFGLAWGMISYFTAFGSVVYSYLYALLSTPLDSQTECHGTHCFRVTFIVCAVSCFVGALGLWLLGRRWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C2T0</accession>
    <name>A0ABR3C2T0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616060.1">
        <property type="nucleotide sequence ID" value="XM_066755774.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988075"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="158"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0253839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="328" mass="38342" checksum="18B0F004DA051D58" modified="2025-10-08" version="1">MDILLEYTDEYVLDKVYNFLLPHPPVPSSLLSINTTVLPDSYPSSTTYYPSLASSSLLPRDSIIRQSISLFTVALLGAYALYFIFCSLSYYFVYDRRLEHHPKFLKDQKRKEIVSSVIAAPWIALMTLPWFVGEVRGYSMLYDNVADYGWGYTVLSVLMFLLFTDFGIYWVHRIEHHPAIYKYIHKPHHKWIVPTPYAALAFHPVDGYAQSLPYHIFPFLFPLHKYVYLGLFVFVQFWTILIHDADMITGHMLERYINGPAHHTLHHLYFTCNYGQYFTWADQYFDSFRSPAPELDPIHDSLRMMKKKGLIDEAGNPIPQTKEAKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C2U3</accession>
    <name>A0ABR3C2U3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616075.1">
        <property type="nucleotide sequence ID" value="XM_066755789.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988090"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046106307" evidence="3">
        <location>
            <begin position="18"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="374" mass="42028" checksum="067D356E60F05CC6" modified="2025-10-08" version="1">MKISIPLIAALAASANASPVRLIVASEPDAKSFDVGINNPETEFPRLSAEKSPIDQLHSGMVAEKKPCHGALSTFWSYMGWNGIPSSTTSTLGRHKGKGKFIKGQPGHKHKHKHHAKLIEEQQRHGLLDSLRSYFPGYTPYLLGGAAASSSTPSEHHIPSEHYIPYMTSEELNTVFYIDRTPEIKWWRPATGLRGKWEVKEGMGEWRAAKKGERPPSRGRKREKFFHRLRRSLDNLTFLESLAIALVIGIGLGSIAHLIMMLVILSCRRLGLAIFSGPRFGFGFRLPQCSSEQRRTGEEAERKEEKETQKATTEASDRQMIEKKEKEQSRGQAEIKLPERDEVVPGGPRFEDECLPEYEEGEDAPFFNERDLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3V0</accession>
    <name>A0ABR3C3V0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616390.1">
        <property type="nucleotide sequence ID" value="XM_066756104.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988407"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0254169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="256" mass="28766" checksum="E85713C295269C8F" modified="2025-10-08" version="1">MSRSSYDRYLTIFSPEGRLYQVEYAFKAISSAGITAVAIRGKDTSVVITQRKVPDKLLDPETITHLFQITPTIGCVMTGLIADARAQVQRTRSEAAQFRYKYGYEITPESLAKRMANINQVYTQRAGMRPLGISMILIGPDDERGPQLFKLDPAGYFTGYKATSSGQKQTEAANYLEKRWKTLEAEKKDLNRAGVIEMAIECLSSICATDFKASEIEIGISSLSPDEKHIDGQGGRFRQMDERERDEWLVRVGEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3X0</accession>
    <name>A0ABR3C3X0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter NIPA-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616609.1">
        <property type="nucleotide sequence ID" value="XM_066754708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986989"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="611"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255332.1"/>
        </source>
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    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="71985" checksum="39D661405BDB3F6F" modified="2025-10-08" version="1">MLGVSTSSFIGVGIACAGNILISLALTIQKLAHRNNEEALHVEQDPSACVTEPPSPPSRPGSRSRFGDPSPIMEESEPPTPQTDSFIHYGDRREEDNGNENGANSRYGQIGEGRYGLGFEGVVATPVTFVPERSISNPEPIPIASRQYKDILRSSSRAPPPAHIFPSTHTSLRVKLDPNPPPHRHSRQDDSGNGNEDVADDYDDDETAVLKITDGRDIGKVEEGMYLKSKLWWLGMVLIAVGEGGNFLSYGFAPASVVAPLGTVALIANCIFAPLILGERFRTRDMVGMALAIIGAVTVVQSSSDTSPRLNPDQLLTALTRLPFLLYTLFSILLLPPLVLLSNSSFGQAHLTIDVGICALFGGFTVLATKALSSLLSGDFIRAWKSGVTWACLVVVGGTSLGQIRWLNRALMRFQSKEVIPTQFVFFTLAVIIGSAVLYQEFRDITRSRFINFAFGIATIFLGVHLLTSTTSPILMAKDEEGNQPPAEQPYEHVPIPYTTSSTSLHHFFSNASERTPLIRSITPAALPVPTGGISGIDGLPRRHSDVPLSRVPSSAPVVGLSTTTPSKGTRLTKRASASSFQSSIPKLGLGSQAGLLLIATTPPSTGYLATRGRGWSVGPTGRTGAGGLRAGEEEASLEDEGQGRRGRSKSIASLFPRSRTPSVARRGGRDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3Z0</accession>
    <name>A0ABR3C3Z0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="91987005"/>
    <dbReference type="Proteomes" id="UP000054399">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="109" mass="11929" checksum="391E8DED085494AB" modified="2025-10-08" version="1">MGATKNEDRGLTVDNLHTLAVKRVLPIQESQGHSNRYGDLQVNAETKPSNASFFHSHHDSMTIILAHSSFDILPVPVIQKEGDILFGSSNLGITLPFSPQNLQICLLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C468</accession>
    <name>A0ABR3C468_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Killer toxin Kp4 domain-containing protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">I308_100232</name>
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    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616705.1">
        <property type="nucleotide sequence ID" value="XM_066754804.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987090"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046107383" description="Killer toxin Kp4 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11711" checksum="46D657151F4A1C7A" modified="2025-10-08" version="1">MLGPATLIFSLSVFFIFSGVIAANKDDQCLSACSDWSVVVGYCRGQYIESTAQQFNLTYMNNFVGCLCEGQTYTGALGNETIMGSAGICASCQTTLALIKKNIQVVNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4H9</accession>
    <name>A0ABR3C4H9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616656.1">
        <property type="nucleotide sequence ID" value="XM_066754755.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987041"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="134" mass="15616" checksum="F975EB5695B7ECF4" modified="2025-10-08" version="1">MSLLPPEEEGDGVEVAWEDQQRINTFSKLNNRLSDIQDLLKVKNEEKEYYDDLSTELELADEDNPQPVLYKIGEAFFYLPLRDARRQLKGDLKKYEKEIEGLESKGRECENGMKELKVLLYAKFGKQINLETTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4P6</accession>
    <name>A0ABR3C4P6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616731.1">
        <property type="nucleotide sequence ID" value="XM_066754830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987116"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33680:SF1">
        <property type="entry name" value="OS05G0489500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33680">
        <property type="entry name" value="OS07G0190500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="295" mass="32320" checksum="744A05D30E0A32C6" modified="2025-10-08" version="1">MPTYTAGNARISTPRRIQITPATPSHDEDGGVACTGHNRRCKRFVSSSAKNPNRAFFVCPLPREDSKRCKFFVWEDEIQKYTKTDQAPETPSAGGSRFGGSKGQVLGQTPVGHSSSSGGLHTPHSLSKEKEAASALSDDGDDFVPMEDDIDWGAIDVDGLEREAIASSQSSVKKHGTLDSISSTPTLGFNERLSSAMTGVKRDRGEEDEDLRTPKKANVDPNPFISSPSDTLPPHPKLLPSISTMEQLNDELYRMDRLLQGSEKLKQGLRNRVKDLESKNKALEDRVKELEARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4X1</accession>
    <name>A0ABR3C4X1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Asp/Glu/hydantoin racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616940.1">
        <property type="nucleotide sequence ID" value="XM_066755039.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987328"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="28675" checksum="F6479DF4ED089D3B" modified="2025-10-08" version="1">MAGLYHDQFGREVAKIQLLLINPNSTSTFTQDVARHLHPRLPNDVGITFYTPPPEAPASIDGPLDGISSTAVILKDLELQPKGQAVNAPEGSSGMSRLATGYSGIVVACFSAHPLVPVLKELLAGYDQPPPVLGILESSILAALQLGPTFGIATTGPQWEPLFDEAVRAMGVSPTRYTGTKGTGFNAVSLRGDKPAEALLDASCFLVQKGAKVIILGCAGMASMRASLQAQLADRVGQSVPVIDGVSSAVDMAIGYARMGIGRTFGPGANEHSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C542</accession>
    <name>A0ABR3C542_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100547</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617017.1">
        <property type="nucleotide sequence ID" value="XM_066755116.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987405"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040345">
        <property type="entry name" value="Mug56/Spo71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039486">
        <property type="entry name" value="Mug56/Spo71_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057379">
        <property type="entry name" value="PH_SPO71"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076:SF1">
        <property type="entry name" value="PROSPORE MEMBRANE ADAPTER PROTEIN SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15404">
        <property type="entry name" value="PH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23207">
        <property type="entry name" value="PH_SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prospore membrane adapter protein SPO71 PH" evidence="3">
        <location>
            <begin position="400"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Mug56/Spo71 PH" evidence="2">
        <location>
            <begin position="896"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1053" mass="119659" checksum="B0DF68D014512E02" modified="2025-10-08" version="1">MAPVHLPFLRYPPDRNSPAPLLKPSPAVLTQVPPPKPPADPSLHVLPRRFLGPIPKKVLNSSHVQEKRRHFHDLRRRAVSKVRYEFIGRNDSLSGLEEDDADEGITRRSALRIPVPGLAGTGGREEDLDPESDHESETYGPQIKVGNEVWFGESFDIGREFVSEGVGTHEPFFLAARERQAARSSESRNQNRRKYSQHERHSVPRRPLNATRSTEETFFTARSRNSEESSIDDCPTPIFEHSPDTQLSQSSSRQPLIRSNQNDADQHPSQQRGPNTKEGKGPANQSLSSSTFTAPQKLKSAFRHTSESPIGAVEPVGIDKPRATDPPRRIKSVQFPMDPTHSVAFETGKTKANHNSPVDPNTVLSRVGEEAQGTSSGAAADAMVEEPKSQKPLSRQGNVLYKDRMLVRVGYHNEENIVSFDEAAQRRNPCSKLDPFEEYIVVWRKGFVEFYQEWRMPFRERMTGSKRMCFAIPLMPHRSSLSIFNPDDLTLCLTTSVEKLQLEVEAVLKSPKTSRISAVRNRVAQSSQVQWLRGHKKGTQIFVLKLAERSRTLDWYWELWRDLGGRLPERIDISIPLISTSIRMSISEDEETVQADSGQLLRHFCPDMVVKTCWEMLRKKKAIDDIVQQAKLQGIKDEGDLRLVWKASDGLLDWVAYPDTVEGKERPWALLAGLARLQNNPSPRELQLRAARHQPKSVKLNDGTLLEEPPGIEGYLFRIHGPTNKSIIYLASHDGCLFMTNKKDSAPPLIPNQEGSTPSEFFSEIHKEFLEYEHRRMGSVIRKSVGCIDMRDIAMIQYPSPPGKDADGQRETFELKFTAGGSMKLEAHTSEIAREWVERLEALKSYWRYRHRVEARQRMDAMSAASGAMHDDGTDEFLGEIWNWCTIRGCRPICLSGRLYMKQGSHNKFRLKYMALTQGTFVSFKVTGKASFHVRKKNYPLFGAYTYSGLLAHEEIHEPHNRDAFLSQHRVYQDGLQSSDGPDDTTFCIRLAISGSHSGENARNPWHSSDNEDHTSIKLSKSPRSLLIFRARSKLERDRWNRFRAYGNVIDQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5N8</accession>
    <name>A0ABR3C5N8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617061.1">
        <property type="nucleotide sequence ID" value="XM_066755160.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987449"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046734524" description="Right handed beta helix domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="51372" checksum="45CBCAA1D83E6241" modified="2025-10-08" version="1">MIPLFSALSFLILISPFFVSAACTDNLTDTAGLQKLLTDGSDGYKLQLCQNQIYSLTNTLNYTASNQEISTEGYPTGDARAVLVVAGFNQSTAVSASGTTQDSAALRHIIINGNRAANESIYKGGGGNIEFGGANSNQVIEYVKSYNPRGWSCMHIAEGQLNCLNATVQYNDIGPCGTDYFQNWADGISLSCSASLVQNNEITDATDGGIVVFGAPFSTVRNNTIKAKTRVMIGGINMVDVKPWKPIGNYSHTVVEGNTIYGGFATSMGNETRGPQEFQAMIKIGLALGPDAWFSDQRFGANKSFGGVIQDNRFSGAFAFGMGITSAKDFIIQNNTFFGNTSFIGNYGPNCTTGDKTPHPSDPLLEEESTLQNTTISVPASSPFQFVNGTAIGLTCFVPPESASYSWPYGDGQVNSEQTDKGNGTSGTSTSTGSASQTSMASTGSPNRNESAAKRVTDLPGVKGLLLAIAWAMSQSITIGDFIVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5S8</accession>
    <name>A0ABR3C5S8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="3">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TIF6</name>
        <name evidence="4" type="ORF">I308_100793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
        <text evidence="3">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617259.1">
        <property type="nucleotide sequence ID" value="XM_066755358.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987651"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="3">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="3">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="245" mass="26331" checksum="B6C559C350AC8577" modified="2025-10-08" version="1">MAVRTQFENSTDIGVFSKLTNSYCLTALASSTNFYSVFEAELADVVPIVHTTIGGTRIVGRLTAGNRHGLLVPSSTTDQELQHLRNSLPPTVAIQRVEERLSALGNVIACNDYVALVHPDIDRETEEIIADTLKVEVFRQTIAGNVLVGSYCALSNQGGLVHPKTSRSELDELSSLLQVPLVAGTVNRGSEVIGAGLVVNDWCAFTGLDTTATEVSVIEAAFRLQGQTSTAVVNEMRDSLIDHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6D2</accession>
    <name>A0ABR3C6D2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein SYM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616613.1">
        <property type="nucleotide sequence ID" value="XM_066754712.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986993"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24987" checksum="568B0B28BFFF4235" modified="2025-10-08" version="1">MRLLHSFARLYNTNFDRRPVATLVVTNGVLNTIADVLAQYSTIVMHNPTPQSPTPTYDPYRTLRFAVFGMGMGPIIGRWMRFLERAIPIPAKASLGTAGKGAGGILTGPAGASAGVGKASGEGIQLVKRVVADQTVMAPIGLVIFVGSMGVMEGHTVEEIKEKFQDIYVPAILANWKIWPIIQGINFKLMPLQYRVPFQSTCGIAWTLYLSLLNAKGNKDLETHHTHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6L4</accession>
    <name>A0ABR3C6L4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Solute carrier family 35 (UDP-sugar transporter), member A1/2/3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616688.1">
        <property type="nucleotide sequence ID" value="XM_066754787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987073"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="631"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="73832" checksum="A12D5719AFC92207" modified="2025-10-08" version="1">MAHRTSNRSPSGLNRRPTDRSTSQSGSMQTASSPVQSTFGGRIYAAPEEDRGLIMRDRSERDRGEKDWADEKGNSMGKTRGMDVGVTRPKRRLSRAMSSTSVSSPPQSPIGQPGHNPYHSLQQQTFHNQKAHGSSTANNYSSYRSNPPKLDDKVGMVGYATAMAAASREREGPPSLWGIELKWISLITLALQNAFLTIIMHYSRISTAPNRTYSAAAAVLLNELLKGGISVSIALKRIDNEMIASPPPPVYSEKLDDKDFDRRSGQKLPSIIHPTRLQALSKAIFSPDCYKLSVPAILYVIQNNLQYVAASNLDVATFQVTYQMKILTTAFFSVLLLRKRLSRTKWASLVLLAIGVGIVQIQSSSAPATSHHTHVDVSHEHQLRSEIPVPDEPIMSPERVMHPIRGFVAVTLACMTSGLAGVYFEFILKSSSGSSAPDLWVRNTQLSLFSLVPALVPIIINPSGPDGAGYFSKVLSCFENFNGWAVGTVLTQTFGGLITALVIRYSDNIMKGFATSLSIIISFLASVALFSYPITLSFIVGASIVLFATYTYNSPPPPVSSTRKEIAVPGSPISTSAPILGEPEKPSRASSVINLLGLGSNHGSRKPSISDIKSYASSQLGLSSYPVSASASAPGTPAMNSHDYAGSGRSSPVGVQASHGGSGAGFGRGSVGDKVRPILSLDIDRKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6U8</accession>
    <name>A0ABR3C6U8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Flap endonuclease 1</fullName>
            <shortName evidence="10">FEN-1</shortName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_100305</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
            <location evidence="10">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
            <location evidence="10">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="10">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616778.1">
        <property type="nucleotide sequence ID" value="XM_066754877.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987163"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 10 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="12">
        <location>
            <begin position="147"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="273"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="409"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0255501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="453" mass="50176" checksum="2245264635716176" modified="2025-10-08" version="1">MGIKGLTGLLSENAPKCMKDHEMKTLFGRKVAIDASMSIYQFLIAVRQQDGQMLMNESGDVTSHLMGFFYRTIRMVDHGIKPCYIFDGKPPELKGSVLAKRFARREEAKEGEEEAKETGTAEDVDKLARRQVRVTREHNEECKKLLSLMGIPVVTAPGEAEAQCAELARAGKVYAAGSEDMDTLTFNSPILLRHLTFSEAKKMPISEIHLDVALRDLEMSMDQFIELCILLGCDYLEPCKGIGPKTALKLMREHGTLGKVVEHIRGKMAEKAEEIKAAADEEAEAEAEAEKYDSDPESEEGGETMINSDGEEVPAPSKPKSPKKKAPAKKKKIASSGMQIPEFWPWEEAKQLFLKPDVVNGDDLVLEWKQPDTEGLVEFLCRDKGFNEDRVRAGAAKLSKMLAAKQQGRLDGFFTVKPKEPATKDGGKGKGKDTKGEKRKAEEKGAAKKKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHI2</accession>
    <name>A0ABR3BHI2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610682.1">
        <property type="nucleotide sequence ID" value="XM_066761142.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993575"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF3">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="92" mass="9723" checksum="6811F74F752B6F54" modified="2025-10-08" version="1">MAEQVDTATDVIQQNAGAAQSAADAKRDAALGPLRSHRTPLPNELSELTPEEQPGGGRKKDDNTLSINIALDLLVEVHLTARVKGDITIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHJ4</accession>
    <name>A0ABR3BHJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610686.1">
        <property type="nucleotide sequence ID" value="XM_066761146.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993579"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="27"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="446" mass="50077" checksum="F24A35002065641C" modified="2025-10-08" version="1">MADTGMRGTNALQDSRFKDKELASIKSTKFPKHFSEKVDLRKVNISVLRPWVAEKVTELIKVEDDIVVEYVFGMLEDRDNPTPDPKKMQVSLVGFMDKYGAAAFMDALWKLLLSAQKTVGGVPAEFIEAKKQELQRKQQESSSLPPPPVPPSSTSHSQARSSAGPVGRSRAEDYYGREPRGGFGGRGGDRGGRGDFPRGRDSRDGRDGRDGLPPRPYPPARSPRNRSRSRSPPPRSTGRFPDRDRERERERERERDWGNRRGNKRGGESFRDRPRDDGWASRGSGGGGGSSANSGERNYRRPTPPHRPSPPASAAPTQSRGTGRGRSFSRSPPPPRRSRSRSRSRSRSLSRPLPPRSRSRTPSPSPVRLRRAHGHEYGRGSPGRGRSPSRSRSRSRSRGRSDTPPRTQTRKHPRSMSRSRTRSRSRSQSRTPVRRRTRDYTPTPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI85</accession>
    <name>A0ABR3BI85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610911.1">
        <property type="nucleotide sequence ID" value="XM_066761086.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993519"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="240" mass="27340" checksum="5790800B35657DD6" modified="2025-10-08" version="1">MTEFRRTQYEHRLANRHCFISVTQHIEIAHHEDALHCLISSPPLHMRPFFVREMLDILHLSLGHLPVGPLTNRIPYPLRLRSPILHHKPVFPHLSPLPILFRQFRHMHWYDLRQDQTLGGRDAIGTVTRVAILVGGGQELDDQSTTFEPRPKIGVVCGAGPVVFGELDDCSPRLEGIKEELGVLKELMPNLLALESKRNQNREVTGSEEGVARQQQPEALRDTSTHWSLTKGLRPISPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJK0</accession>
    <name>A0ABR3BJK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611352.1">
        <property type="nucleotide sequence ID" value="XM_066760591.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992999"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="81"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0241970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="174" mass="18352" checksum="B709488FC1CCEBF2" modified="2025-10-08" version="1">MSNSWYDTLTSAPALIATALGVSVAALFVSTRNTSNSNNNTAAQIKEQIKEVAQSVHAEGSKGKMAQAGASIMSAPAANLAPPKHDGSDPSKPIYVAIKGKVFDVSSRGEMYAPGKGYNVFAGKDGSKGLGMSSLDPRDAVADYSSLNEGQMNTLNQWEAFFEKRYSVVGRVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJX7</accession>
    <name>A0ABR3BJX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611471.1">
        <property type="nucleotide sequence ID" value="XM_066760167.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992572"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0242089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="412" mass="44374" checksum="1763604B83B943D7" modified="2025-10-08" version="1">MASLSPVSSSPTTTASSVLETSPSAPAAALAATTITPLISTSKPKASKPRKRVNTAEKRSQHNAIERARRETLNSKFLDLARLLPSLASSRRPSKSAIVNGSISHLTYQRKQRLLAAKLLKQVLVERDELLREVNEWRSVSGCALKAGTAWTEEMDEVTAVEKEVFGNFAGVAGEEDGDGEMEDGQILATPIEGNKFMPLNSGMWSEFNYGMNPANGFVSSTSDTISQTSPVGSQAHTTVLTPTSVTEPQTVYNHTPSPSSSQSVGRGAEAPKEGMPTVPSQSNHFNQQLLNWSQQFFQLPMQQPETATALPRPPQQAPPQMQNQRYNPMLPEPFNGMSNPLQMGNGVVPGQGQDVSADAFTQQLMASMFPGKYTTAQPSISDLQKAVRAGMGLGLGMVSNQWPQENAVEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKW1</accession>
    <name>A0ABR3BKW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BSP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611809.1">
        <property type="nucleotide sequence ID" value="XM_066759863.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992263"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0243442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="800" mass="89134" checksum="F09AFAB7F111027D" modified="2025-10-08" version="1">MDLPTLRQLKNSVIGNTWKKVQLAADTPTLTDLILLLHPANSPDTVYEAAVIVASIATVGNLTLRPIITNNTPARLLHLIHPLVHTQQHRSAQRQLTALLRALRNVLVATADMVWGHVWGVGAEKKVVGTGLVGENILRETPADRSRDKHWRNDALAALTIVFQPGNLSTLLSLLNSPNHQIVLPLYQLFSRLVALPSNLQALVSWISPDQSIAPLLQESEVDVHPWSTFFMLRHLLINIIKPDNELFDRHSRPKLMEAYLDLLGAIAKGDCSICGEIRQWLPPYKDDKLNTMEDYQLEVVVPQILEIAKSTHRAVRLAAIGCVTSIVKNDKGPYYDNHIRRIPHEDITEQILNDLTRLLQTDDHEERVKLNFILAALVSDEPLLQRSACEHKIPHQLLGKLCSLPELESTLSPDLYARLLESSLLALASLAMAYNRTRSIIADYPELDGPLPSCPIVLTPLKILRTSLIHESYGVRAAACQLARSLSRAVSVMRTGMVDEGVGDEVVKLLKRELETKSKEGMDDVLGDAAWTVEVAATATICNLIADFSPFRPVILSDNTLPIIVHLTHSSYTPLALNALWSIKNLLFHADLPTKSSFMSIFTYPWLRQIISSTMPEDIQEQGLEVVQNLLAEESGAEVMRMVERLGGEDVDGKRGGIDGFLDFLVDLLSDKGAPMCSEVRLSAMYVLVNLSLGNEKLRTALMARVELLEVLSEALNVPRDPLKIPAILTYHNLLESSAKTHRPRQNILDILEPYLLKPRLKKLSEESRNLDVVQKSIKLLDVLERERATKTVTVPSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL13</accession>
    <name>A0ABR3BL13_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611488.1">
        <property type="nucleotide sequence ID" value="XM_066760184.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992589"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27098" checksum="D9E02E6EEC12CD20" modified="2025-10-08" version="1">MTREDHKQDSGLRAVRAHLNNRPDLLLAIAMRHATNPLLHPVPDPLTKNPTRTPPSLRLSVPHGSPTYDALGIKLRTKAREVDVDIPLQSTAKTASEVKQAIDKMGEDALKYYKVPKDPQVNVFVLPKFIHTLIFLPLALLLYLAAAPPTSNTANAGRALVSKYLSDYMIPASLVFSFACHIIVEPFMLITKIDKHRVPIIPALCYMFTVILIGFGGLNALDRAVIQERLRIIRSRSAEAKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLI6</accession>
    <name>A0ABR3BLI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin efflux carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612021.1">
        <property type="nucleotide sequence ID" value="XM_066760075.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992477"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040254">
        <property type="entry name" value="Ecm3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274:SF1">
        <property type="entry name" value="AGL149CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274">
        <property type="entry name" value="PROTEIN ECM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0243654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15758" checksum="06DDE744B09C215C" modified="2025-10-08" version="1">MTSATGVIIYKAFAPTIKIMICITIGFVLTKKGLFAPANAKGVNILSLNVGLPALVFGSMVSAFTSENIKAFGPLILIAVLYMILGFICAWFVREFFFVPPDFRYGILVMGALSNWGNLPTAVVQTLAKSAPFDPDTDVELGVAYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLJ6</accession>
    <name>A0ABR3BLJ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611999.1">
        <property type="nucleotide sequence ID" value="XM_066760053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992454"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0243632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="178" mass="19507" checksum="05FFC4C94C3206D1" modified="2025-10-08" version="1">MSSLDPPAGHTRPIVFFDISIGDTPAGRIKMELFDDITPKTAENFRQLCTGEHRINSVPQGYKKATFHRIPQFMVQGGDFVRGDGTGSFSIYGAQFEDENFKVKHTGPGLLSMANSGPNTNGCQFFITTAPAEFLDGKHCVFGRVIDGLLTVRKIENVPTGANNRPKLQVRIAECGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLT1</accession>
    <name>A0ABR3BLT1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611559.1">
        <property type="nucleotide sequence ID" value="XM_066760255.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992661"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="144"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0242177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="314" mass="34483" checksum="70A5E641100DC6F9" modified="2025-10-08" version="1">MAEHLMFKGNLAGHNGWVTAIATSSENPDMILTASRDKTVIAWQLTREDNLYGFPKKILHGHNHFVSDVAISSDGQFALSSSWDHTLRLWDLNTGLTTKKFVGHTGDVLSVSFSADNRQIVSASRDRSIKLWNTLGECKFDIVEDGHTEWVSCVRFSPNPALPVIISAGWDKTVKVWELSNCKLKTTHHGHTGYLNTLAVSPDGSLAASGGKDGITMLWDLNEGKHLYSLDAGDIINSLVFSPNRYWLCAATASSIKIFDLESKSLVDDLQPDFDGLSDKARKPECTSLAWSADGQTLFAGFSDNLVRVWAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLU5</accession>
    <name>A0ABR3BLU5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612131.1">
        <property type="nucleotide sequence ID" value="XM_066759484.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991880"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="216" mass="24231" checksum="FF4A63255BBB2351" modified="2025-10-08" version="1">MTADWLGPRTFPNLWMKVCKLWVVVALGALIMPLIVWIMIFIENTKTFSDTMHHYLGNDQSVYDQMDRDPDAGYVGNTNIPKHLGGVIFTAALDIAMWVIIIIAACADLFWRFPICKQLIDAFHAQGLQNTKGLVDIEFFFLVANAFLKLFIVAATGSQTYTGLYPDNKQVDTPLFCLYATMILLCSIPLTLISLLFILHAMKREEYAAAQKTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM08</accession>
    <name>A0ABR3BM08_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612031.1">
        <property type="nucleotide sequence ID" value="XM_066760085.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992487"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="173" mass="18859" checksum="3C25655C7159CDA4" modified="2025-10-08" version="1">MGIYKNWKVYSTLIAEKRPQFCEEHVIPYFTVVGISCKGLSPSTIVGRIADLQRLFQDADALQKPNQHAGEGVTEEDIAKGIDTWDSDISTPALLQPTITDKEVEELEESDFSMMTNCHRREGISTADEGRDCVEDSEEAEGILSILGAAGKGSAVNQEASQGAQGQKQVLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM27</accession>
    <name>A0ABR3BM27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612214.1">
        <property type="nucleotide sequence ID" value="XM_066759567.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991965"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0243847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="283" mass="31363" checksum="7B066125B14A295D" modified="2025-10-08" version="1">MGISQNEKSVILTHESGTSVEIYFYGATVVSWKQGGKERMFVSSKSAMDGSKAIRGGIPVVFPIFGPPPPSPPEYASLSQHGFARTSIWKFDSVVMDRPEGVSVRFVLPSAPPTFPHQFKLSYVVTLAPHQLSTDLHVINSGKEKFSFQALLHNYLAVPDSSKIKITGIDKGTTYKDKVLGGKIDEWDGSTLVIDRELDRVYQKVPSREITVDDGAGSGYKVRFRGFEDCTIWNPQEATGSKMADMEDKGWDKYVCIEPGYVREFKTLSPSEELILAQTITVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM52</accession>
    <name>A0ABR3BM52_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF431-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611863.1">
        <property type="nucleotide sequence ID" value="XM_066759917.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992317"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24349" checksum="10FEA196D7BE04EB" modified="2025-10-08" version="1">MSNKSFKYVIEHMEEDDATTRSLPEWVTLEYSHMLSLVGPSSTVHFTSLSSTSIPPLTASLNNNPKAQPTTKPILELLPALSPPVDKARVCLLDPKAEKVIAPDDADKFDVFLYGGILGDDPPRDRTGELRKLGFEGRHLGEKQMTTDTAVGVTKKVIEDQVPLDEIPFVDFPTIKFNKVESIEMPFRYVKDENEEPILPPGMKAHLKADLDRTIDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMB4</accession>
    <name>A0ABR3BMB4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">26S proteasome non-ATPase regulatory subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105203</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612307.1">
        <property type="nucleotide sequence ID" value="XM_066759660.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992059"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF11">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25213" checksum="159220662EEBF407" modified="2025-10-08" version="1">MSSFSVHKAALEGQIGLARSLLNDDPKLINSKDQDGRTPLHWAASTSNLSVLQMLLNYHPDLEAKDSMGWTALMIASAAGHSEIVKELIGAGAKVDAVNEKGQTSLHYAASKGNVSIGRLLINHGADINAKDRASQHPLHRAATTGNNAFLQLLLNPPEGRPKTRLNTADRAGNTPLHLAMESGHGDAAVVLIEAGADRERSNSEGQVPEEIEGVGGQEQKKVREYVASKVGRRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BME1</accession>
    <name>A0ABR3BME1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612332.1">
        <property type="nucleotide sequence ID" value="XM_066759685.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992084"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="334" mass="38206" checksum="24C9590710D02FDD" modified="2025-10-08" version="1">MLAPPQRSKRRRSPSPSLEPEISDLASPLDILLKRRKKEQHQHFGLPDSPNSGPLVSPVHTYDQDYFNYYQNAQAESSSAAQLKPGLEMGIERRRTKQWERINAPPNGMHQHQQQYHHPQGHLATPVTHAAQTAESSPRYPFATPLPVHHASNTAPLMSSSPVRNQPPSSSPFREKVENMQQEQWIDEEEMRREWGEAYTEQNSLLHSLHLARLNTTVRPHSSPRSRSHPSHAYRSPNPSSSTLFSPARTSTSPYIQQTPYPQSSPYTPARPPPPLHTHSYSSHYGMNEKMGDDEDMNDESEVEIEVKKRYEETNRLLCELAVVRRQRWGEAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMK6</accession>
    <name>A0ABR3BMK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612372.1">
        <property type="nucleotide sequence ID" value="XM_066759725.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992124"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0244005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="532" mass="58594" checksum="5431EBACFEB4E073" modified="2025-10-08" version="1">MATVDDKYSIDHVEAGGDDFKHHVTQEEVKHGDNALKYLGDERVEVTEEDDVRIRRKTDKYILTLLAWVYFLQILDKTVLGYANTLGLSHDTHLVNNEYSLLGSVNAIVQLAWQPFSSYLIVKVPARYLMPAMVFGWGAAQACMAAAHNWAGLMAARAFLGLFEAGCLPLFSLLTSQWYRRSEQPVRVAVWYSTNGIATIVAAILSFGLSHVDSPHIKGWQLIFIVCGIITCLTAPIIYMFVDADVASARFLSEEDKAKGIERLRANQTGTGSNEFKLSHVWELFYDPKSYLFLALALLLNVGASVTNIFGPTLIKGFGFNSRITSLLNMPFGFLQFLAILAGCYCAYKFKLKSAVLAAFIVPVVIGLALLYVENAAAVLKQAPALVGYYLLAFLFGANPIIVSWIVANTGGQTKKALLMSVYNAGSAAGNIIGPLLFQDKDKPHYLPGIKATLGIFCALMACVGITAAVLFILNKQRQRQRVAVGKPQYIKDTSMSNKYEAYGSDDTDGRLGQNALLDLTDFKNDEFVYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMZ2</accession>
    <name>A0ABR3BMZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104559</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612518.1">
        <property type="nucleotide sequence ID" value="XM_066759031.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991415"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0245434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="174" mass="19366" checksum="1A724F9E27C4D185" modified="2025-10-08" version="1">MPPFTARPLNSSKSHPIFAQIRRHPFVLFGLPFVGIIVGSSFVLQAFTQTRYDYQETKVKSMGKEEELGMKSGRRKVDLKEEYYRLNNPASDSSSLDSALAAPTSLSSPSSLDASLVSVPAPPKKKKRFSMASVSQDDYEPVRVPRPEGVPEWGAGKSGEEAPMKGYRREDRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN74</accession>
    <name>A0ABR3BN74_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105191</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612295.1">
        <property type="nucleotide sequence ID" value="XM_066759648.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992047"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="601"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="724"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="777"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0243928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="864" mass="95506" checksum="7B433E87C87E4027" modified="2025-10-08" version="1">MPRQQSEDEHGMSGQAPRSPRGPQGKPLERNSKLEDEEELDLIRRYEDFSTVDWIQDSLHERTFQNKAPRSRLIARLDRSDGAVGYLWRLLRRALEEGEAYVVISLVGVIIGVSAAIISIITGWLSDIKMGHCTTGWWLSRKFCCLELSDEMEACAEWKNWGGVEPFGWISYVLFAAAFSFSAAYLVKNFAPYAAGSGISEIKCILGGFIINGFLSVETFFIKGLTLPLAIASGLAVGKEGPSVHVACSVGNVVAKWFSRYKRSHLKMREIITASSAAGVAVAFGSPIGGVLFSIEEMNQTYSNRTMWRSFVCALVATFTLASMDPFRTGKLVIFNVSYDRDWHYFEIPAYVLIGIFGGLYGALVIKFNIQMASFRRKHLSGHGIFEAVVLASITAIIGYLNGFLRIDMTEMLSVLFRECEGGGDYNGLCQASSQWRMVNSLLLATIMRTVFIIVSYGSKVPAGIFVPSLAVGATFGRMIGILVKAMYNSYPSAPWFAACAPDAPCITPGTYAFLGAAAAMGGITRLTVTVVVIMFELTGALTYILPTMIVVLVTKAVSDQFGGGGISDHIIKFNGYPFLEKEDKEDPTDHAFIEPIANVMKKDLIILEATGVPLNHVVDIVQHTDYQGFPVVKSDGDQTIVGFVRKNELRIALEKARRIRNLSSDATCTFQCIRSIPDDAHELLERPEILIPSQGGGLTVDTGTENREDTEGEISHVDFGQYVDDMPLTVAPKMPLEIVMQLFRRMGPRIILVSDQGRLTGLVTVKDVLRHELSEAHHRSRSTHTPLTPSHPGYVQSNGWETDWTAVDERGHSLEIALEEGLEWTRSKATWAYGAALERWRGIRGQDRRTATFDYELDEGRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNC7</accession>
    <name>A0ABR3BNC7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="8">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_104520</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="8"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612481.1">
        <property type="nucleotide sequence ID" value="XM_066758994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991376"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="411"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="13">
        <location>
            <begin position="500"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="146"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="277"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0245397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="833" mass="92938" checksum="9C08449042F8FAD2" modified="2025-10-08" version="1">MVAFTATGNRNLTRKIRVTIVAADSLIKRDILRLPDPFAIVSVDSEQIHTTSVIKRTLNPYWNENFDIDVKDSSIVAVQIFDQRKFKRKQDQGFLGVINIKVSDVIDLELGGQEMLTKELKKGSDGQAVQGKLIVYLSTQTNAPVSNNTAASSSTNVATPAPAASSLASNNTAGQSISRPASAIQPAQAPEASVPTSADTIASAVPQPATQTVGVSSSGAPNVNPTTQAASTGQTGTSTSVGHEFDSHSDQYGPLPAGWERRIDHLGRQYYVDHNTRTTTWNRPSDNQLSNSATQATSTGEARARHNQRTLPDEMLDVQQSGANSGGATTPTTGGAQANPVNASNATTAGQGPLPSGWEQRFTPEGRPYFVDHNTRTTTWVDPRRQQLLRFIAPGQQGNLSVQPQTVSQLGPLPSGWEMRLTSTARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKRDFRRKLIYFRSQPALRSNTGQCHMKVSRDNIFEGSYTEIMRQTPNDLKKRLMIKFEGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPNSGVNPEHLNYFKFIGRVVGLGIFHRRFLDAYFIVSFYKMILGKKIALQDLESVDAGLFRGLTWMLENDITGVIEDTFSITEEHFGEVVTVDLKPGGRDVEVTEDNKKDYVDLVTEYRISKRVSEQFQAFMSGFNELIPQELINVFDERELELLIGGMSEIDVDDWQKHTDYRGYNPSDEVVEWFWKIVKNWPAEKKSRLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEVTQLPKSHTCFNRIDLPAYKSYEALEQKLTIAVEETVGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNM5</accession>
    <name>A0ABR3BNM5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612445.1">
        <property type="nucleotide sequence ID" value="XM_066759798.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992197"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0244078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="363" mass="39217" checksum="CDBE31B4FB351611" modified="2025-10-08" version="1">MSASQTPTLPPSKPSSPAPVYRRTPLKIGCVQYDVKLGRVKENAAKVEELTKWMKPGHVDLLVLPEMCLSGYVFNSPISILPYLEAPRIGPTSLLARALATRLGCHVIAGYPELIPSSASPSPSPTITTDTAPKEMEGEALGVGYNSAVIVSPTGEVVGNYRKTFRFETDKTWAREGDGFQYFDLSEPLGRVAVGICMDLNPKDFIAPWDAFELANFCRDNAVDMLVMPMNWLSPPAEPPITTPASGEEPPHPVEPPEDPEAPSEANLNYWAARLVPLHDPTPRYSTAPSTSTSTPIPGSGPKSGREGEGKEVVFVACNRIGEEEGTKFIGTSCVMTISSTPSRIELVECCNISEERVMIATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNS1</accession>
    <name>A0ABR3BNS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612803.1">
        <property type="nucleotide sequence ID" value="XM_066759316.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991710"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF8">
        <property type="entry name" value="LD22649P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="161"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="588" mass="61742" checksum="753CBCEB3789B7B6" modified="2025-10-08" version="1">MQPPSSPASATFPSHLSDVAIWGSSNDHASTTNSVVLDRADSFVRRRHTPLGSAASLGVAAGRSTPSLLSDSGTVPGPGRHRPSRTLSATPSNEHPLSYTSSPPHDPQVLPDTRPALQRATSATERQVAESSRSGSEWGSTRGSLDVLRMSSVDESSGEVEVKPQESPAGIALLYGIDLATLRKVNKLWASDPIHIRTHLYVPLDACRWNKASETLVRGPGEGQVTLMPKNAKDKGKGKETGELVAAGSGAGQNDGVRFPQSISGDNLHSFLSSTNIAYDRPTLQSIPPAGPYPNGSAVNSPISPTPETIPRVLDVVRIPSSQLRFFPRPRPSESSSRTSTEHDRSSPRGGNTHRDEHDGDSLSNALRRTSLALNTDRSEGNGPSIVPNLSTLPEPFRSPSIPSGSFPLQAATGGKPSSHTRSNKSTTVVRLRPPQPPPIQTGKNNNTLANRLSSFFTVPPPPLANNNMSPISGGGSGPASSAGRLPQGGKARRSLESTGSHGTATPPKSATSATKRGSGIIDSSATSTSMGKCKSKTRGGGREQREEMELVTRVREQGVGSGMGMGMGNGFGARKPVVKGKKSQKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNY3</accession>
    <name>A0ABR3BNY3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612859.1">
        <property type="nucleotide sequence ID" value="XM_066759372.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991767"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="31"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0245775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="367" mass="43526" checksum="59423798589887DF" modified="2025-10-08" version="1">MNTIREINRINERELELGVKGSWHDEYKDSAYIYVGGLPFELTEGDLITIFSQWGEIMDVNLVRDKETGKSRGFGFLMYEDQRSTVLAVDNMNGTQVMGRTLKVDHTRNYRQQGKRNENREYEEPEEPTYNAMPPILSDSGSSSSEDEENDLDEEDPMAEFIRAEKKKEVKKIKGNDGDGKKRKHEGETKEERRARKEAKRAKKIEKEEKKKRKEGRERSERAKSVKSERDERKRQSKEPEDSFWSRGKNASDRDDWRQGKWELEKEEESREKRGERPRNQDGDVVKNVLGSHYNRSTGKGDTGSGREREREGKPSYRREDDRRQDDDRRRDARDRDRAYSRRDDRDWGHDREGYIRRGDRGRDTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP17</accession>
    <name>A0ABR3BP17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_105965</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611718.1">
        <property type="nucleotide sequence ID" value="XM_066760414.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992820"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="46"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="294"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="617"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="617"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="708"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0242336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="724" mass="81477" checksum="3D44CC150A54C7E9" modified="2025-10-08" version="1">MDAPVPAAPAFGGSWAKLNPPLSPWIMDVINTMGFKNMTPVQAGTIPRAVKNQDCVVEAVTGSGKTLAFTIPVLERLSRREEPYKKGEIAAIVVAPTRELATQIHAVFGRFLSSLIPPESEEETADVEGHAPPIASSSRSPSPLSDKPLFPLPMLVTSGTPTPYETFQSTHPSILIGTPGRLAAFLLNPRGLAIVRVSELDVLVLDEADRLLSSPDHRRDVERIMRHLPKQRRTHLFSATMTDAVEEMIGLGLRNPVRIVVNLKDKRKNGEEPKERRTPMALQNTYLVCRHAEKTLQLIRLLLSESTNHERSKFIVYFSTCAAVDYFYRILSRLPLLSKFHLTSFHGELPPKIRETALSTFTSHPSSHLSPAVLLCTDVAARGVDFPDIDVVVQYDAPTDPKTFSHRAGRTARAGRRGKAVLLLGKGREEDYVDFLNIRKIPLTKQPYISASLEEVDTPQILDPEATTLLHSIRQIILTDRELSDKAAKSFVSSFRAYSKHEASFIFRTLDFDFNSQAISFGLLRLPAMPEIKDWKKKKEAERQRLEKIKSEGGEVEEREVIEWGDAEVNWDTFAYTSKQREASRLATLAQRAESQSSNDAARAEARAKRKIKAEMREAWSEQKERKVRKEERREKKDAKKKYEWELEQANGEGDRQSDLADIAKAQAERKKKREREEESWDEEMGKEYKSLKREIKEEKSVRKSSKGGMGGGGIGGGMFDDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP90</accession>
    <name>A0ABR3BP90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612967.1">
        <property type="nucleotide sequence ID" value="XM_066758519.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990895"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="350"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="392"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="478"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="755"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="643"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="884" mass="97625" checksum="E3B59EC9406500B3" modified="2025-10-08" version="1">MKSNFVFQNLCGTVYRQGNVVFTPDGNSVLSPVGNRVSVFDLVNNKSRTLPFENRKNIASIALSPDGSVLISIDEDGRALFVHFRKGTVLHHISFKRKVHHVSFSPNGKYIAITHGHIVQIWNTPSHLVREFAPFTLHREYTGHHDEVVSVCWSKTSRYFITTSRDMTARLYTINPLEGFQPKQFAGHRDVVLGAFFSQDEKTIYTVSRDGAVFVWKAKKGVSEEDSDIEMDVLDAPTTSTSAANLALEHAVAYTRWGVHARYFFNQPGTKVVCATFHPKTSLLIVGFSSGVFGLWEMPEFTPVHTLSISNEKISSVAVSASGEWLAFGAAKLGQLLVWEWQSESYVLKQQGHYYDMNTLAFSPDGQNIATGGEDGKVKLWNASSGFCFATFPEHTAAISTVEFAKQGQVLFSASLDGTVRAYDLIRYRNFRTFTSPTPVQFSALAVDPSGDVVCAGSQDSFEIYMWSVQTGKLLDILTGHTAPISGLAFSPTGNQLASSSWDRSIRLWSVFGRSRATEPIELSGEATALAFRPDGIEICASILNGELTFIDVEEGQIKSVIEGRRDISGGRKVDDRLTAANNAASKYFNSVIYTADGACVLAGGSSKYVVLYDRAEGVMVKKFQISENLSLDGTQEMLDSRKMTEAGTMDSFDRQGEEEDLEDRLDSTLPGASKGDLSKRRYRREARTNCVRFSATGRSWAAAGTEGLLIYSLDESTTFDPFDLSLDLTPESVMQTVANGDHLIALIMALRLSEKPLIQRVYESIPPSSIRLIARQLPGVYVTQFMKFISDHIENTPHLEFDLVWTAAMLTSHGKFLRERKGEMAATLRGLVRGLMGLEMSVAKISDENTFSLNYILSQTGKADQIEFEEGEGDAFILDVDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPD1</accession>
    <name>A0ABR3BPD1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104086</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613013.1">
        <property type="nucleotide sequence ID" value="XM_066758565.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990942"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="361" mass="39698" checksum="15EDF1D8F93E7501" modified="2025-10-08" version="1">MVRISIPTLPPAPLVPPNALTLLPTRLAASHLARFLEKGDGKTVILTGAGVSVDSGIRAYRGKEGSYSNPNYKPILFHELVEDTPRGEMFRRRYWARSFLGYPPVRDAQPNPTHIYIAALLHLGLAPNLITQNVDNLHPKAYRLLSPNTKPPILELHGTLAKVHCMKHRHEQSRDEYQEQISRLNPIWGEAAKEAERTGTQPRTNPDGDVDLRGANYNSFNVPSCRICEAKGEKPGMVKPNVVFFGETIPPAIRDESFSLINSASSLLILGTSLATYSAFRLVKLALDQKKPVLMISTGPSRADGLPGLEKMDRVAGDVLGTYLDSVVKGNRGTEFDAVRKILHTGVIKPVPDVDRPRAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPJ4</accession>
    <name>A0ABR3BPJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613073.1">
        <property type="nucleotide sequence ID" value="XM_066758625.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991003"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="151"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="340" mass="36791" checksum="A4C2C25A825D1269" modified="2025-10-08" version="1">MSLPPAILQNNNSSGGTSDHVVPADGSTTVNDSTITLPSSQDPTSPSASTPNLIPNSASRVSVQLPEQPLSHQRSHSGSGGYTNNANLPSAMSHHSHFPRSSTNSSVQQEGKYRRKVGFEAFEAGPGTLFAFTCQSKSGGYKRSRNTRVFAVAVSPDESGDTALEWLMSELVEDGDEVVAIRVIEIDEGERHSEKAQEEFREEAQALLKTILEKNDEIDDLRKISVIVEFVAGKSTSTLLKMIALYRPDSLVVGTRAQRSRLQSWGKALGAPGMGSVSRFCVSHSPVPVIVVRPERKVKKHLEKRQNDPKRGQYAAIVGPDGLALSRSRSRERSAGGMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPR0</accession>
    <name>A0ABR3BPR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcium binding protein 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613142.1">
        <property type="nucleotide sequence ID" value="XM_066758694.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991072"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="38263" checksum="B0276ED5BBDB7C2B" modified="2025-10-08" version="1">MNFFNRQKTRTPADTVKGLRDNITRLDHTPAGEGSKKINEDISRQLSIVKTLLSGEGDSEPNPDAVAQVANEVYAQDLLSSMVVHLGKFDFEARKDVCNIYSILLRRQLGSRSPTVDTIATRPDIIFNTLQGYANQDIALNTGMILKEMLRYEPLARILLYSDQFYTFPSYIENTSFGISCDALANMKETLTRHKPMVAQYIEANYDRFFNMYNTLILSPNYVTKRQSLKLLGEILLDRANYNVMTRYIASEANLKMMMNFLRDKSRNIQFEAFHVFKVFVANPNKPPQIASILRRNKEKLLVFLKEFHNDKDDEQFNDEKQFLIQQIQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ39</accession>
    <name>A0ABR3BQ39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104342</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613267.1">
        <property type="nucleotide sequence ID" value="XM_066758819.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991198"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="29"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0247306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="538" mass="59064" checksum="880C589A7D31BDD0" modified="2025-10-08" version="1">MAGALGSLINKKALENTPKEVFNLYVFFIAFILSLSGGLHGANTSNISGILSMPDFIATFNMKHYSASAASNIKGWTTSVIVLGGLIGALTSSPFNDRLGRRWTLFLNALIFSAGTIVQLVATGNINQVIGGRAMQGFASGVGTVTGTLFLAEIAPKAIRGVLGAFFSFNIMLGVSLGYWVNYIAILHISPKSHWQWRMPVLFQLYPAIILLSALPFLPESPRWLILRGKNDQALHTLARIRRLPEDHSYVEEEYNEIASSVNTEIEIAHSTSWLGLFRELKNDRTLLRRFILVMIVQLGFNFSGGNSITYYQTSILSTINVTTSDGAYLFSGIYGLMKVLAVLVYAFLLSERFGRRKMLLIGATINILCVLWIAIYLGVLAGHNKAAGWVAIAAVCLFAIGYGIGWAPVAFGLNGEVFPNRMRAKIMSLTIGMQYLANFCLTRFFPNMIANIGAFGPFAIFACVSALIWVYVFVALPETKGLSIEQMSSLFGGHWFQNGFNKAGDKASESENVTPIEYDGVEETKKEYSHVERISTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ41</accession>
    <name>A0ABR3BQ41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105697</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612093.1">
        <property type="nucleotide sequence ID" value="XM_066760147.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992552"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0243726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="411" mass="45152" checksum="304DA6DF1F93ECA2" modified="2025-10-08" version="1">MGVGALSMLVPMFNAELAPPGIRGSLVALQQLAITSGIMISYWIGYGTNYIGGTGEGQTTAAWRVPLGLQLVPALVLCVGSCFLPFSPRWLMLKGREEESLTNLAMLRKSTEDAPEVQYEFRALQAERLVEREAAKERYGQEDVNFRVTMAEYKRLFTTKPLLHRLFLGAGCQTLQQWTGINAIIYYAPTIFAQIGLSGAGAGGTISLLATGIVGIVQFVFTIPAVLFVDNFGRKPILAWGEANMAISHAIIAALVAIYGDRFTTHKSAANAAVFFIYWYIANFACTWGPLAWVVSAEVFPLDMRAKGMSVSSGANWIMNFTVAMVTPHMIESIGYKTYIVFMCFCVVGFLFSIFILPELKGLSLEEVDQLFHDTSGAEDRARRDRIAAQIGLDKVANQIQHREKANDAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQK1</accession>
    <name>A0ABR3BQK1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104487</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613409.1">
        <property type="nucleotide sequence ID" value="XM_066758961.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991343"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="8">
        <location>
            <begin position="80"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="198" mass="21614" checksum="02A0B83FE9121636" modified="2025-10-08" version="1">MSKVSSTFTRQLTSLATKINRPVPQRALHIPPLKPSPASSSLKANSERSSILTSQFGQKRALHSSLPRWHGDLVRPEPGTGIKLIFRDSRGNDVKTVEGNEGDDILSLAHEHDIDLEGACEGSVACSTCHVIIDPEHFDMLPEADDEENDMLDLAFGLEDTSRLGCQVKLTKELDGMVATLPSATRNMYVDGAKARTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQK5</accession>
    <name>A0ABR3BQK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103526</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613422.1">
        <property type="nucleotide sequence ID" value="XM_066758020.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990382"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="819"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="863"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="969"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="825"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="864"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="981"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="992" mass="108462" checksum="95CA9217C27BD8F8" modified="2025-10-08" version="1">MASPDNPEAGLIHSQPQPPPADPQPADQQIKKKSKQQLSCAECRRLKLKCDRDIPCSNCVRRGCRELCPDGVKETRRAGLDAKTAEALQKRLSTLEGFLTEHGFEVDDDNGAVHRRPSSSSRSRTDSNPLTMRRGSIIGGGGSGGGSGGGGGEDWGSSKDTPISPFQSTRSYHRRSRSPSRRTHSISEHQQPPRYLYDSPAPSRDNPFSYNPSLSSSHNHNGNPSIPSQTQSQSQAQGQQPISLSHPHSHSQTQLHLPPISSFSTSTSSGTTIPAGSPVEHSHGTLVLGKSGRSRYLGPTAGTEWLKNQEVGGIGMETPSNSRSPVDTTCSGPGGPAGGRGGRGGEEGVYHGRESGGASCEPIYSFPFNESEMSTVEELFERLPPRADAEVLIDSYYRYFAWNHDPAPRRTFQPIFDRVYTSILQPRPENSVHLQQLALVYMLLAMGTVHNIELPPHDESAEEYLTLAQAAMTKGNFMNHATIAGLQTLVTMAHYYLETESGRNGDSAWPLWGLAMSLVVAMGLHRDGARWNLPDDVVQERRQVFWECHTIEVFQANCFSRPNALVPRYIDTAFPSPNPAEIAMGGKGWPTLKFELCQISSQVLDAGMTVHFQSYDSIQKLYSQLCEFELNVPYDLRCRSALLALPSVYPDPEMARRNSPEISRHNLHRTLQQFTLSLNISENILFLQRPYFVMAMHDEPADPTRSIYGHSYLAVVERCNVIIQVVSDLYKLHPTIISRQWFFWYHLFTAAVCLGTLILKNPQSALATFALSQIEQAIHVYSVLIKQNNSPSMVQNHDWLLRLQQRGARKIAQAAGMGGVNLSSGSGGGGGEGDAGGQEEEDRELLGWKTRLIERAGSGVHTAVNISSSSNPAGSVPQRTPSPDPLTQNGGGNSGITPAMHLLQQHFVPPFQSPPVSGMLGTTAQTLGMDNSTDLLLHQFWNPMMMADSTNMTQNTNWWSWDLGGLAENGTPIGGGAAGLQTQSQPQSTPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQR9</accession>
    <name>A0ABR3BQR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_104411</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613336.1">
        <property type="nucleotide sequence ID" value="XM_066758888.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991267"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="15">
        <location>
            <begin position="53"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="16">
        <location>
            <begin position="205"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0247375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="478" mass="52476" checksum="D5CB4FBDC7445E8E" modified="2025-10-08" version="1">MPASRILSRAIARPPVPRVLKPSLARNLAAVHPVAVAADPVTRTSTLSNGLSVSTETIPGASTSTVGLWIDAGSRADAPNASGTAHFLEHLAFKGTKSRSQTQLELEVENLGAHLNAYTSREQTVYYAKAFDKDVPQAVDILSDILQNSKLEESAIERERDVILREQEEVEKQYEEVVFDHLHSVAFQGSALGNTILGPKEHINSISKSDLQSYISKNYTADRMALIGAGSIEHEALVKLAEKHFASLPVSSNPIPLGGQSHTPAEFIGSEVRIRDDSMDTINLAIAVEGVGWKSPDYWPMLVMQSIFGNWDRSLGASSLLSSRLSHIISSNNLANSYMSFSTSYSDTGLWGIYLVSENIMNVDDLTHFTLKEWTRMSISPTIAEVERAKSQLKASLLLGLDGTTAIAEDIGRQLITTGKRYTPREIERYVDAVTPEEIQRVAQKYLWDKDIAVAALGRTDGLFDYTRLRADMSSMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQV6</accession>
    <name>A0ABR3BQV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613532.1">
        <property type="nucleotide sequence ID" value="XM_066758130.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990499"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="685"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="76"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="706" mass="77125" checksum="72495CE4EBFEFD30" modified="2025-10-08" version="1">MLGSPGAHSPATPSNPRGRKTGLKSRATQILALRFGWVVLVIWYEVGEFFHSLSTCRFPDSALRLAHPEAPAPTHVVLIADPHVPHPQLSYPPGNPWLNWAKQQMDELFMRKSWNVVMRLGRVDQVLVLGDMLDWGRGVMTDEEYEEYIALFRSIFQLPPTTPMHFVPGNHDIPLAPSSRFSSQARLRYQQHFETPNTVLSISNHSFVLLDAVGLVEEDYRRYAAEMQFGEWDGVKGGVIEFVKDLRDNPLPGPKILLSHIPLARPEGATCGPLREKGRISKGAGPGYQNLLGSETSRFLLDAIQPNIVFSGDDHDYCDYVHKGNIREVTVKSFSSSAGIRRPGLQLLSLVPPPTESTAGLLPTHADRPCFLPDQLGVYWRVYLPLAILTALYLFITNLRSAYSRWDRSSHPLSEKTRSSPALLSAEAISPNSFSSRRNGPVPLSIPSRKSSSHLPLSASSATSSFILPRPVRYNSMTAEYPSSSRGGPSNPVSPFGSPKMSAVDRFAEGDVERDGEAASGSVTGLNTPLTLSRRSSYVYMDRSFPSSASDSAPLSASGTAGGGLGVNTGIGSPSSSGFIRRVSSANFSSLTATNAAPPILSVTSPDTPRRVTLPSPSLLPLSPAHGQPHPLSQASSHATLAQPAVIYTFPTRSKSWLWFDRAKSFLRWTWKARKGAVGRSWRELVSVAWVGAVVWLGVNALFFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQX1</accession>
    <name>A0ABR3BQX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613549.1">
        <property type="nucleotide sequence ID" value="XM_066758147.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990518"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="117"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="402" mass="45295" checksum="41BAC3525A6E4749" modified="2025-10-08" version="1">MPSNAPIPGQFEQDTRVSFDQVSGKWQYEDDEGTEHEWNGTAWIPIIDDELVKAQQAAYSVPGVDESTPSNAAIAREERRNKKRKKGEKDYTSNTSNAPAAHVTSKPVPAPSVPKKTGVWVTNLPPNTTVQKLADVFSKAGVLHIDDEGNPRIKMYYDDEGNFKGEAWVVYFKEGSVDLAITLLDDTELELGAGYPPMRVKVAEYFKDQEKGKDKEKKEKNEEEKKKLTAEEKQRMSKRMKTLQSKITWRSDDESDDAAAPLGGAPAPTNNRFARVVVLKGMFVLEDLEKDPALLLELKEEVREEAETLGQVTSVILYDKEEDGVMTIKFKEPVSAQACVAKMNNRYFDGRVIYAGLYNGKERFKKSGGRTFDEDGDQEEKERLDNFAHWLVEGEDEEAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR50</accession>
    <name>A0ABR3BR50_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103738</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613622.1">
        <property type="nucleotide sequence ID" value="XM_066758220.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990594"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="223" mass="23534" checksum="5926BA064F7D1B08" modified="2025-10-08" version="1">MLDTTVKGLPPPPTAYDGSRLRIAVVHARWNDRIISALLAGALAKLRQQGVKDENIVVKTVAGSYELPLACKKLIEAGKTQSANAAPSMLASTTNLLSLIDNTSSAQHTSAQSQTPAQSQTPSQPTASTAPFDAVIAIGCLIKGSTMHFEYICEAVSQGLMNVQLQTGTPVVFGVLTVLNDEQALVRAGVGSGEDKGHNHGEDWGLAAVELASQYKEWEKGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRM6</accession>
    <name>A0ABR3BRM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104967</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612915.1">
        <property type="nucleotide sequence ID" value="XM_066759428.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991823"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="183"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="640"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="523"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="738"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="768"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="788"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="815"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="869"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="901"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="936"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="952" mass="105032" checksum="AC6FF76AB20BD34D" modified="2025-10-08" version="1">MSDPPTPLTLPTTLPYPITLTRLVARPGDKVKRGSRLLEYTFMSSDMREKVAKRQSQGGGMGEIANGNEKDDLSGTWESLIDGDVVEWKGAKPGMVIERNQASQVIVTVQQPCSHPVQLHGMCGICGADLIEDDYLSRPALNQTQAGPSRYPGGFEIAHDAMGVTVSKNEAQRLENLTRDALLSTRRLSLIVDLDQTIIHTTVDPTVAEWMDEIHREELMDAQGKDSAPTEEAKGKEEEESTTPPGSPGPSALNTTVELSKEKNPNAEALRDVAKFQIADDLPPGYVKLKTKAAEGQNPPESEGRWYFTKPRPGLQKFLDEMSQLYEMHVYTMGTRTYADAIVNVIDPDGKIFGGRILSRDESGSFSSKNLKRLFPTDTSMVVVIDDRSDVWGDCPNLVKVVPYDFFLGIGDINSSFLPTNKSTPPPSSAATTAAAAFSSSASLSSSLSKSPSPPPTLSPSPPSASSIASTPSPVTLSEVSADLEPIERINTAEPTIEEELMMKTRLLDQLSTSRPLARLQEELENEDSGDDESGQNQDGEANAAAETGMKTVTEKEKEEEQEEKPTTRERDESRKERSRSPSKHRKPLLNPDDYELVRVAKILQEIHSRFYKAFDALEGWDPKKALPMSCDVEFIIPEMKAEVLDGCSLVFSGMIPREADPSTTTIWQTAESFGALITPSLTSRTTHLVTALLNTEKTWRAGKMEGVKVVWAQWFWDSVALWERQDEEKYIAGKKEGTGGAEKRVEAEAGVEGETGNSDNHKNMSKEEEDGEEHEDMNDDTQVGQGWDEEAEREWEEFMAGEDDWSDEEGSVGSRKSMTSVKSESAPSTPSKKRVRYADEELLPLEEFKDPSPTVLSDAPPSKRHKAHLVEYTKPGEEASEEHRSRHKDHGMYEPDFEKDDEKSGDEDHGRSVVEGMEGTDGDDEFALLLMDSLANDDADGDEDDGDRDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRP2</accession>
    <name>A0ABR3BRP2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103938</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613821.1">
        <property type="nucleotide sequence ID" value="XM_066758419.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990794"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="12">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="278"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="377"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="592"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="656"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0247860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="696" mass="78720" checksum="F03D1F1764A70A45" modified="2025-10-08" version="1">MSVQRCPQCGPDGQLETDLSAGNIVCQRCGQIVEEGILVSEVGFAESAGGRVHVQGTFVSNYATGVAGSRGGRSGQQNIENIKAQGASRIEALSRQMHLSSAITRGAIRFFSLAVDNKFNRGRKTDYIIASCLYLQCRLKKDAHMLIDFSEHKGINVFELGATYLKLRSTLNLLDPMPEVDPAIYNLRFAHRLNFGAQVNTVAADASRLVRRFRADWMTQGRRPAGVCGACLIIAGRMSNFLRTPDEVAQVVKVHPNTIKKRLLEFAQTDMAKKTVGEWRSLSESQLDEVSEMEKPPIVREQERKRAQEERKRLFLNGENDEDEEDEEDVDEEGRPIKRAKLNKDKSHAPNDDDQMTGALQAAAHDFEYANVVSVEDDEDDTLDPLAPSDYVQQLESARDDPTQAREERRRDRTDLLKGIKGFGQEDTVEDIDMDELEQLASDAEKLEDEDEEDEVDEDGDAIAEPTQLKTVSQAEAAAKKPGLFDAWDDEAAVITFFEEKYFHGEKNLYQANMANRIKMWWGNRDPKEVYLEMEAVKRARWLREKNARQLNTDLDDLDDDELEAVFVLDEDAKQARARMWLSSNGKWLEEEKEKQEKRAALQRARGNDPSKNKPKRRRTAPHKGPYKSSDQAVQSVIKSKQFSGRVNYDVLRGLGLTGSSTAGLVAMEDEKEEYEEEDEEEKGEDEGGYDNWNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRP7</accession>
    <name>A0ABR3BRP7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613820.1">
        <property type="nucleotide sequence ID" value="XM_066758418.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990793"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="150" mass="15735" checksum="48311964C4B28EDA" modified="2025-10-08" version="1">MAPKKVRAPQEAAVSLGPQVAEGENVFGVAHIFASFNDTFVHVTDLTGKETISRVTGGMKVKADRDESSPYAAMLAAQDVAAKCKEVGITALHVKLRATGGTGTKQPGPGGQAALRALARAGMRIGRIEDVTPTPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRQ0</accession>
    <name>A0ABR3BRQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0246984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612945.1">
        <property type="nucleotide sequence ID" value="XM_066758497.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990872"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0246984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="610" mass="66750" checksum="B61A159E8E083F0D" modified="2025-10-08" version="1">MSNALYVLRLLWRTPPPPSPRTISSIALPLAAATTPSVPPPPPPPFLEDESTEYATAARTLADLPPPAPAPIPWPTLFPRHTPPPPSPKFCDPLYRLVVQAQYGAALAIHAELCAHKVYIQRRHEYLAPAIAALDAGHAEQFFLWLGLYPNKPATANTPELSRIWDPVVARVVAVFQSAGDTAFLERFLGTASKLGVLPTVLPPLSPHLTFTLSPALSHSLLSTSIAAYTRYTTSAESTSKRAHVQRRMVRRQVAVIWAAYLRGLVAAGWREQARELFENPPGVEWDAFTRGYVESRLQGFTPTATPPRDSPLSKQVLSTCLSPSQLASILDSLSSQPLCTTHPTLLPRFKHRFLRQRLGAASGPGTRERERTWLHAEIINLQKQGRHEDAVQLFVEHFFWLGLPPHPSLPSAFAATSESKQKQTQKHYPSIQILVTLLPSLLPLLPPPLSSSAPKYLNAYVQLALDSAPNSTLHSNSSSDSNSRGTTAPPALRPNNVMWSVVVREIVHWGGNKGLEHGRNVLSAAQTAAVDDSDSSGPGEAAYRALLLALAGRRRVHEMYELLDYMEVSDSVGTSTKTGFWKGVWGGLGRVGYRVSFSSSFYIISILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRQ9</accession>
    <name>A0ABR3BRQ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613513.1">
        <property type="nucleotide sequence ID" value="XM_066758111.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990478"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="144" mass="16901" checksum="536C347B46F1CBFF" modified="2025-10-08" version="1">MEQYKQYTFFKEWDHEDRFTVFPPYRETMEQAQGKIPFFKCHPGAQKIMLLKQCQYLWIQTANALLCMEEALDNYAREADAFGAHNETVDQFGFTSRHASKLFEDMEGVSLGEELMRNLLEDPAQWLPPLLELEDAPSDLLSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRS0</accession>
    <name>A0ABR3BRS0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613528.1">
        <property type="nucleotide sequence ID" value="XM_066758126.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990495"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="170"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="433" mass="48077" checksum="30D843FF426F0247" modified="2025-10-08" version="1">MLLMIQTALRRGTFHTTSTTRTPAALRTPPPALLSLSCHFSLLCKPLQPQRSTRSKLSKAPKATKSPKSPKLPKAPKQSKAGKPYKTRKPINPPKASVPPETQITIELPISAEVPVSPKYPAAPKNSSSSKHPPFDKLVIMVRAADVVNRMEMPEELPDFPLPPLPDIYDRELLRQVFTHTSYVGARKQSALFDKEAFHHDNEKLEHVGDALLGCIVTCLLHDLYPNLNPGNATEMKAICVCNQTLSQLSRRYKMPGRLITDVNATEVLKNGTKTTANIFEAYVAGLHYSYLKHGNTKDVDGGDGPKTHGQGLEHLQEWLRPLFEPIAEWVLGYMKKEQERLEAETAVKVGSMDTDLDDLANGASGKLNELFISRGAGMPVYTYEPWGVDMWKAIVIARNRDGKEWQGEATRTKKKQAATVAAYKVLMQLEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRX9</accession>
    <name>A0ABR3BRX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612753.1">
        <property type="nucleotide sequence ID" value="XM_066759266.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991659"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550:SF70">
        <property type="entry name" value="JIL-1 ANCHORING AND STABILIZING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="440" mass="48192" checksum="A6EFC88304B5D8E8" modified="2025-10-08" version="1">MSSSSPAVDDKPASTKKPGPKSKTGSKPAPVDHKFEIGDIVLARLRGYPPWPARIANPETLPRNVLKTRPGKNPNLYCCQFFPAGDFSWLQNKDIKALSSSDISSFLSQSHRKASGGLREAYQTAQDPTEWDAQQEEIHKQQEEAEANVDELEDEDEGEEVAVKGGKRKREEPKKKKTAAAAKKEEEPKSKKAKAAASKAGDKKKTAAASKAEGDEDPLASNPECVKVKDWRHKLQKAFLGDSMPAESEMPHWNEVFESVESYDSMTIEALQYSKIGKVMKKIMGLTTIPLNDKYELTKRAGKLMHQWQEFIDTANQGSMANGQKKTARPTAAAAAASAGEEETPEPVKDKEDKPVDETPARTTESAPVEEKEKKEEVEAAEEEKKGGATEEEKKEAAEEEKIEEEGEAKTAAAGPEPEAEAGAEKTEANGEEEKMQVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRZ4</accession>
    <name>A0ABR3BRZ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613911.1">
        <property type="nucleotide sequence ID" value="XM_066757527.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989881"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="357" mass="39188" checksum="15BD9E1D7206A526" modified="2025-10-08" version="1">MMMTSPLVQPHSRPISHTPSPTSSPKLVPVPSTMASISLPLSSSALSALPSTTTSQNTLNQSTPTRSFARGPQARPYGPPTLRKKELDGDTKRFAELVVETVEERRRLLLASSSPVSRGRTLEGEKGSIETVENVHLQGVHHEPRNIERRGTQGRLMSSSWEAERADLIVDYPVWSPGCFQDLSTLQSLREKTLSHIHLLLSHLQNVHHIHATYRLLARSAVSFPTTNPSPFHHGWGCIRLAPCASQEQGRAGAKVRRASPVHARRPLSFSPEQKMNDSAVIDSDDEDSSPQMSPRTTTADIKLREGFFNGSASGSEDEDEEEVADVVVAREIEKRGGKEGMAFLMTLFGQPAIILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSA0</accession>
    <name>A0ABR3BSA0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103122</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614007.1">
        <property type="nucleotide sequence ID" value="XM_066757623.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989978"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="12">
        <location>
            <begin position="150"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="321"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0249820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="380" mass="41666" checksum="DBDF29279F1DE74E" modified="2025-10-08" version="1">MQPPPTSLSDVLLPLHRCLADIQSYQLPRLSTFSGPPDMHSELVDELRTDLESIRHQLGIAKELSLYAPQQPQAQEVEEIEREYIRLKSDFRRAMVDSKKALASRQSRAHELSLKSDLEPNSSTDETTRDGEAKNAAQLGIGGDDELQTKTNEVTVALRRTTALMQTELERSVLSVQILESSTQTMTLTQSLYETYSSLLASSTQLVRALEKADTMDRLIIFAALFFFLCVVGWVIKRRVLDRTVGVVIGGVGKGVGWYLGGSWRLIRMALSGGGGSERGHKGLEFADQRIGGGMVDGIEEGVPIPQVGEDSAIGGVKLVPNHDDVPPPSPGSQPSQVQGMEEINKINAERRGGKVGIVPDDEGERIAPSWRQDQGREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSJ0</accession>
    <name>A0ABR3BSJ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612963.1">
        <property type="nucleotide sequence ID" value="XM_066758515.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990890"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009991">
        <property type="entry name" value="DCTN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28360">
        <property type="entry name" value="DYNACTIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28360:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07426">
        <property type="entry name" value="Dynactin_p22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27025" checksum="E19ECDF8F36D0D29" modified="2025-10-08" version="1">MTSSLLPLELRIRILETQLFGVPSSLLSDPDSPSPTSTSARTSPAITHRIRNVEQCLHQLGESSDGVKWLLEGYEQYLPLLTIPTASGPLPNPSFATQTSTLSSSEQANQTLTPTPIHESSLLPDSVKLAMVLEAASDIRGAERDLREIEILKSRQVEGSGELEQLLPLRPNLKQAMQEISQESHIVEHARKNVGQLLLRYNDFMSTVSELFIDLHHQIEDLEEDVLRVERKRRKELASRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSK7</accession>
    <name>A0ABR3BSK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613936.1">
        <property type="nucleotide sequence ID" value="XM_066757552.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989906"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0249749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="302" mass="32613" checksum="AF238827AC1655B6" modified="2025-10-08" version="1">MAEIPNSESTFDGFVQAFVMIVVSEIGDKTFLIAAIMATRHSRMTVFAGAFASLVVMSILSAAMGRVILGLIPKVWTLWAASALFLVFGAKMLQESFSMASGSSHIQDEMREVEEELEEDSAVHDSHNARGTAIPLESIEAGTSTRSPRGSTSRLERSASPRPSRSGPSIHFPLSGGNNVGPLEKGKHWTVVLKEKIRTTLQITTNPVFAQAFVLTFLGEWGDRSQITTIAMAGAHSVAVIAFGTIVGHSICTFGAVLGGRYLSTKISVKHISLLGAAAFIIFAFLYAMEAYYYDDDIEANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSL7</accession>
    <name>A0ABR3BSL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612993.1">
        <property type="nucleotide sequence ID" value="XM_066758545.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990921"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="328"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="457" mass="49965" checksum="E4AADFDD4BEA5149" modified="2025-10-08" version="1">MDISAALQEASSQQNQKLRSQAYLSLLQSLLQPPLTSASPLIAFGTHFTTSNTVIIIVGRRILGAYLTALLAGTTVVQKGTAKVPLDEEGQADEAEWIALGEAAFSGEKGEEVRRDVVEGVLAAGSSGWCDEQITVLRHLHSHLLMLEEDWEGAARGLMPIQLEGGSRLVSDDEKLNVYMQIVRLFLECGEWGQAQTYFTRASLLPRPTDKETRLSMRLSQAKLYDFANDFAKASVAYHEVSHDTSIDPSDRLLILSAAVTTSILAPSGPHRSRILATLNRDDRVHTELPAGLGTMLKKMLLEYIVKPEEMKEFEGALAPHQRAVVEGGGTVLERAVREHNVGACAKVYDNISFSALGAILNLSPSSAETIARRMIEQSRLRAWIDQPSQLIFFESRPQLDTDADAQGTAGGLGVEKEEKEVEKVSWGVRWDERIRGTSLRVEGIAEGILAKGLIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSW2</accession>
    <name>A0ABR3BSW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614232.1">
        <property type="nucleotide sequence ID" value="XM_066757848.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990206"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="150"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="551"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="589"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="632" mass="70074" checksum="88BCA34CFBBA92A3" modified="2025-10-08" version="1">MEHPVLPRRKRRRPQEDEDLNYELGLRVQTLESLLRGTGSFIDANQAHAAAHETVRDATKAAKAGSQDATNALAQLSQGVEGMSRGAQSSLLLDVLQQLTAASMGRPLSGDSSAASGERKGLELWSSLPKASQETTVAIASAFEDDDSPNKINICTPGYRDETGKLFVPPTVRYAEKQFHSESMVSREALPIEGHASFLDAGVKFAYGGDSHPYRHKRVAAVQAVSLTGALRLAGTFLSRFPTLPPTKTVFIPSPTTDEDVTALQDAGLEIRSFRFLDLKTGGVDWESLREDLQDAPMKSIVLLHVSGSVPSGAELTTNQWRLLASLLREREMIPLAIMAFQGLSSGDTNRDAQALRFMVHEGLPVILVQNFDATMGLYADSPSIVSIVTRNSEDKDRVESQLRAIGRGMWTHPSPWGAHIAHQILTDGKLHPSWLKEIRLMSNRLRSARNKLYVQLVDKLNTPGDWAHIKKANGMYCTALLPSAQTEALTAKHHIHLLPDGCFNLGSLNSSKINALSRAIDSVVREGIREAEEAQAQRLAMELALAAAKEQAAREETQREEEREAAEMRAAREEDTLLMERSIANAIERQKREEEEERKREEQRKREDEQQRKQREREEIARQAEAILATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT35</accession>
    <name>A0ABR3BT35_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_103422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614302.1">
        <property type="nucleotide sequence ID" value="XM_066757918.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990278"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="69"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="434"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="708"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="744" mass="80938" checksum="B9A7E01234C06B3B" modified="2025-10-08" version="1">MSNNPTTTPSIGAQGSASSMPSFPPTSSNQSSFKAPPNPNIPQDIAVIMELVANNEVVGALPPVDISAAEKRKQVEENSKSKKQVEEGSSSDSDSSSEFESSSEGESDDEKAVNKKPMTAEEHQTLKAQLDAFIGENHDAADVEFEYDSDPESDDSEDYNFSLDKMGFEFMEDDEDIGPVDPGPVLSRNEAPLPAVPPPPMTKLPEGERLSLAGDVVSWMPEKKLETWLEKKTGGIEGGEGKGFVDVEKRVDEGLLSGVEESEAKEVEKELAIDPQPESVDISIEIGAVAEQQTASKDTEAQTGQAATAAEELTKKASKTEPTFTSAGTVVVRAMQSRPGDFDDGWLEEGSILCWEDGRVLGTVYETFGPLTSPFYTVRLPPPPFPYPTPGSLATGTRLFYPFNPSYRSFVNMVAVRDPRYKGTDASNIYDEEVAEEELEWSDDEAEAAAKRERKHKKKSKKQPSVAGTPRGGRTSLPSREHWDHQHNDETMSEAGSLYGVGDDNRWEVGSDVGSNASRRGRPVPISYGDLDDLSGQSTGGRGSGGRGGGRGRGNQGRDRGRGRGGRSSYPSSPRPIQDQPYSNQWQPGQQFMPSYPAYGQSYPQMMPSYPQQPQNAFTQHASYEPHQPSAGMGAIAHTYTPQGQQGAQGMYSPQTQQQQQGMYSPYSQMQYGGATLTYPMQPQGQQGGVAINPRFAAQYQMMMGMAQMQAQQQGGQETSYGYGQQQAQQKHQGEEQAQEQPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTA8</accession>
    <name>A0ABR3BTA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylenetetrahydrofolate dehydrogenase (NAD+)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613530.1">
        <property type="nucleotide sequence ID" value="XM_066758128.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990497"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="1">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="2">
        <location>
            <begin position="186"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40198" checksum="AD27718CC9AB276A" modified="2025-10-08" version="1">MSQGILITASKVATPFKSELLSTLASSRFSSRPPHLVGILATKKEDARTYAEFTKKACETLGINYELRLVGEAREGMDGEGVGIEVEEAILEANEDPDVDGMMVYYPIYGGRQDQYLQSVVSPQKDVEGLNHQFLFNLYHNIRFINPLTLRPIPASHLPEILPNKSGSNAKNEDVAPEGTVKSILPCTPLAIVKVLEHIGVYNRLLAYGDRARGKVITIINRSEVVGRPLAALLANDGARVISVDLDSIVEFSKRPSKAVEGKKPLTSPHHIVTPLPDMTLHKALNHSDVVISAVPVDSFKVPTKELKDGCVCVNVAGEKNFDADVRDRASIYVPSVGVMTITMLQRNLLRLCEYRDMIKEQGMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTC2</accession>
    <name>A0ABR3BTC2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103354</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614236.1">
        <property type="nucleotide sequence ID" value="XM_066757852.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990210"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="426" mass="48021" checksum="13A4BF35785464F3" modified="2025-10-08" version="1">MPKRGRHSLSLFTSLPEELRRSIHSKSSDTTKLTIQHPVSNPSVPINTLLGTQTLLHTQPYSDHGQEEEEGGKEVDVLGAKSALVNDSRTNVESGEKDMTMMEVSQAQIPKERQPSPKQNEPYQMEVSASLSPNAQRESESYGLNWLGGTNKIVKPSTAKARKPAKKRQRQTGPIENPYIDHPWDCTGLVPRFTHIDHVPKQLQKYFRQRGLLFPEYDRLPLLLDHTGWFSVTPQPIAAHIAERCQCDVIVDAFCGVGGNAIAFAKTCERVIAIDNDITRLKIARHNALHHGVADRIEFILGDYTEFARSFAEKNPEDKIDVVFLSPPWGGIDYLNSPSATYSLSSILPIHGRDLFNLTSKLTPNIAYYLPRNMDMQEISELARELDYPDPERKGRVREWVEVEEETVRDKVKALTIYFGGLVADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTH5</accession>
    <name>A0ABR3BTH5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103721</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613605.1">
        <property type="nucleotide sequence ID" value="XM_066758203.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990577"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="38"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0247644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="338" mass="39513" checksum="F4FADAD439AF15F2" modified="2025-10-08" version="1">MSGGRSVARVYANVNEKLGRSWWDYDNLVVQWGVQDNYEIVRKVGRGKYSEVFESIHLPTDSKCIVKVLKPVKKKKIKREIKILQNLAGGPNVVGLLDVVRDSQSKTPSIVTEYVNNTEFKTLYPKFSDFDVRYYIFELLKALDFCHSKGIMHRDVKPHNVMIDHEKRTLRLIDWGLAEFYHPGTEYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGCMFASMIFRKEPFFHGHDNADQLVKIAKVLGTDELYTYLERYDIDLDAQFDDILGRYPRKPWSRFVSSENQRYISSEAIDFLDKLLRYDHQERLTAEEAKGHPYFEPVRQAATQSSASQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTP3</accession>
    <name>A0ABR3BTP3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102497</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614511.1">
        <property type="nucleotide sequence ID" value="XM_066757042.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989354"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="314" mass="36006" checksum="66521C077C47D97E" modified="2025-10-08" version="1">MGEQPEIDLDSVIDRLLEVRGNRPGKAVQLAEYEIKYLCTKAREIFISQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLQSMEQIRRVMRPTDVPDTGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLLCSFQILKPAEKKPKYGGYGGSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU41</accession>
    <name>A0ABR3BU41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BCKDHA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614139.1">
        <property type="nucleotide sequence ID" value="XM_066757755.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990111"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="4">
        <location>
            <begin position="139"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0249952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="504" mass="55619" checksum="424947C96168CA96" modified="2025-10-08" version="1">MRIALQAVTRCSRPPLIASASRRSLITGPPPNIPPIHNTTSASAPLPFPTPLPSFSPPSAQDAKPLYVPGSQAERQARAGRMSRPLRRGTHESWWSAEMGWFNAVAKTIPTFRVLDEEGHMVKDGHGSQATKEEMLSMYRTMTLIPIVDNVLYQSQRQGRISFYMQCAGEEAAIVGSAAAMLANDEIFGQYRESAALLHRGFKLDALMAQCFGNVDDKGTKGRMMPVHYSSPEHGFHTITSPLATQMPQAAGAAYMLKLDEDRQGDCVICYFGDGAASEGDFHAALGMNSVLGGPCIWFCRNNGFAISTPIIDQYAGDGIASRGPAYGLDTIRVDGNDALAVHAAVCEARKRAVEGKKGVLVEAMTYRVGHHSTSDDSSMYRPIEEVKEWSVVDNPIHRLRSYLVSRKWWSEEEEKELLKKNKAEVMKAFSRAEKLPKPKLGEMFNDVWGVSPGEEVPAVIIEQRAELGRLLKKYSEVWPPWKKELKKFAEQGEDVMDCDGKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU76</accession>
    <name>A0ABR3BU76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614678.1">
        <property type="nucleotide sequence ID" value="XM_066757209.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989525"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="6">
        <location>
            <begin position="297"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="573" mass="63522" checksum="7E39052748B0F58C" modified="2025-10-08" version="1">MSTHEKVHLPTTSLDRPCAPRPYGPRLKILLPLFGILVFLLYQNSSNVISKLHACQHFRLEKLSDSDKCPIQPNPLNVGEDWNPLMDQAYGDLAAKRLSKAVQIPTESFDNLPKDGSDPGFDKHYVLADFIESEYPKFYQTLKHETVNSHAHLFTWEGSNKSLKPILLMAHTDTVPVLPETLHQWRYPPFEGSITHNGTPDTPGTWIWGRGASDCKNSLLGIYGAVERLVTEGYKPERTIIISNGYDEEIGGIRGSGAIAKILEERYGKEGISFLVDEGFTGVSQEYGALVASLGMAEKGSANVRVKVETLGGHSSVPPVHTGIGVMSLVLAELEKNPFEPTLVPSTPYFKYLSCMSEHAPEVPKSIKRQIKNPRKWKKLAYDLASSDRTLNSFLATTQAIDLISGGVKVNALPEYVEATVNHRIAFTSSINETLEHISQLIVPLAQSLNFTISAFEPSATKTSNFHITLDALSGFEPAPITSSDSKSFELMAGTCKHVFGKDTIVSPSGMFANTDTKQMWNVTKNIYRFTPALLSENVNQHTVDERISLNAHLNTTRFFYKLLRNTEGWDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUC8</accession>
    <name>A0ABR3BUC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">No apical meristem-associated C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614229.1">
        <property type="nucleotide sequence ID" value="XM_066757845.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990203"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42240" checksum="ECACF986AF1748C5" modified="2025-10-08" version="1">MAHHHFVGINPAGLSFSHPTPPADHPAPPSSGSIHTPANFASIQEPIADPNAVAARRRGRPSTRGEAGVTPPPEIGWWEDRAPSWHKDAMQGGKSSMEFLMEWSEEMKNQGHYYWMGVRDGGNLHQGASRFRDYLYAQHGPIRRSSKAIRNKVENIKQKFFEAQEWLKDPNGDHTTMTIPDVEKKLNKICRNYRFWETIFVELPPVDHEAGQNAEGSSSNQTLQSASQPAVRQGSGPLIRGIPVPETAQAAVDDAQRNVRRRLNDGSAAPISSDASLVGRVLPASYLERTREEREREKHELAKKQQALSREQYELEQKRDERDQKRFEWEQTKHLVETALKIRELDIIPLEAAMIKARALYGQARDEDQAEATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUE4</accession>
    <name>A0ABR3BUE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613905.1">
        <property type="nucleotide sequence ID" value="XM_066757521.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989875"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0249718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="273" mass="28812" checksum="CC83EAE96C3F69A8" modified="2025-10-08" version="1">MPPAKSNKFKTSRFPAVRPSTFTAQTKLDPQARIKRIMQLDEEVGKLASATPVMISKSLECFIQVLLDESCKTVREAGARKLTAGHLKLMINTNPSFDFLRELTESIADLPSAGISASGAGPSKARKASTGVAGKGKGNGNRGDEGVETWAKGEQDRLRSEEGSMAPGWRAGVLPPTVATGTGMGAGGAMPWSGGESGSGSGSVPHVPPQSTLPPLQLQQSQLPPQPQPEEIQQPQQSVTMIGSWKRDMTGGGGTGEGGRGMFDDYEEDEDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUF8</accession>
    <name>A0ABR3BUF8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103739</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613623.1">
        <property type="nucleotide sequence ID" value="XM_066758221.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990595"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="7">
        <location>
            <begin position="56"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="8">
        <location>
            <begin position="428"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="10">
        <location>
            <begin position="629"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="9">
        <location>
            <begin position="828"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="11">
        <location>
            <begin position="999"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0247662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1220" mass="135532" checksum="7992FBC4ADE50547" modified="2025-10-08" version="1">MRSLSPLRLAVAGLPPALPPAAIALDPETAALYVAAESPSPHGVHVDILQVIGGSVQPIASFSSPARAPFSTPEYAPETLSLHCLADERSLVILLAGGDIATLALHGPDGSVAPVEVVGSVDSGIKAAAWSPDDEQIILVTGEDNLVCMTRNFDVVHEEPLRSRAFGQDKFVNVGWGSKSTQFHGSLGKSAARQPADTAPSVSHPTDHGLPIISFRGDASFFAVSSLDPYHPEGSESESGEARRQVRIYARDASAGFQPKLSATSESLPGLEPALAWRPSGNLISTIVRYGYHRGGEGRQGRWDVAMLERNGLRHGGFELREDKTDWEDGRIRGLGWNSDSEVLAVWIERKDRDVVQLWSMKNYHYYLKQELYSHDTQKPRFRGFEWHPEDPLSLYIICQDSIQHRTFTWDTFAARLPMPHDTASVAVIDGTRLLLTPFRTQNTPPPMSSYHLTLPSTPVHACLSNWDDTAAAVFANGHVMVWKLNTRLPGPKGSKLRGGGKVAEPVMDFERKVGDGERVFRNLALGPGGKVAVLSLAAVRPAGATTEQSGRVNVFGKGVQDEEIEVESGVERILWTDKGSILVLNGQGRLYSLGSKEPIDMTLPSQPTSILLSGHLLFTLSPTSKLHVVKRDVLAGAYRAAFLTCRKHRLDLNILYDLDPEKFMANLDNFVEQVYEVDYLNLFVSSLTSEDSAKAVYGEQARENTTSTIPIPADKVNTICDSLRTLLEARGLEKYVETILTTHVCKIPADYESGLRVLLQLQADHPEIVEDAIKYIIFLSDVNKLYDVALGMYNFQLVLMIAQYSQKDPKEYLPFLRELRALDKWDQRFEIDDHLERRESALANLKQAGSERFEDAASYLAKYELYDTAFKLYKDDQEKLIVIHDLYGDYLYDRREYTDSALSYLMANKPQKALKAYERAHAWRELFALAKKEGLSKESLDEMIERVTDYLGSRGRHLEASQIFIEYSSDVDSAVDTCCRGAEFSEAYRLTSIHDRSDLVEAMIHPGLEEAHEALIEVFEEMDGQLDKETKRLKELNEIREKDHDAFYIVEREIDIEGVDVATNATTVASAFTRYTVAPSTMFSQTTRMTGQTAKSKRGKKRATGRRGTVDEWEYLVMSIGRLLARVDEKSAEALTLLRHLILASSDHVALAQSLQSTIIAFRTKLSNALDEAWQERDAVLKEVVESGGSGLEGGLDKSLGEVKPQVGEWKGMGLLLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUS5</accession>
    <name>A0ABR3BUS5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102895</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614899.1">
        <property type="nucleotide sequence ID" value="XM_066757430.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989751"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="10">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="351"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="687"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="828"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="974" mass="108496" checksum="A824B4FC9B075EC9" modified="2025-10-08" version="1">MTGHYRDSHESPPDIPSTQFIPEANDADNLYEAVEIMDERGPPVDGEYLIKWSGTDEYGRPWKPSWEKKSGCTDALIMEWKEKKRRHPTIVGKEGEKLKRLDKQEKAPKTKKRKRKSELVVKTEPGVTPVKKTRTSVGKAAARSRESVDSPASTTKAGRKSRASHPSVSAGTPSESPAPVAGPSGRGSSVNLHEDVSEDSDGSNHVSRHGGTTRFRPRESHIEPNSPETQRSHAPLSKSSSAKAASPKSDQRPKKSAITLSGSKSRESPSQSSLRRTVTPLHFQSPNPQARSGDKSPLFLMNSSIEPNDTVEPSHTLASAVGSQTEGIERFSSPPFMRHELLACGQQEVRKLPHEQSSAVRRTGNSDDEEVQVITKSPSKGKGRASINIDNDEKAAKGDNILSSPNFNLNELSPSKRPVPVSRGSSSYGQHPAVVDLENAKKKIARLEGELTDSEKARKKAEERPKDLVDPAELRKAKKEIECLKAELKNAQDARISAEDLLAHSGNDETRKFSKLSKQISDLRENLMAVQVEKGDLEEKLKENPDSEELAKVQKEFDEQLKEKKDLELEKESFKLLLSSLNDDLDAARKELEISNTQNAKLEKKVNVDSAELAKMRKEMGDLRNELDSVTTEKEELKHQLRNHPDTAELAKTREEIKDFNSIINDALLKKTKLEEYLANHPDTAALADARSELKSLSSQLTEAKQSLSSSHAEVELLRERIASMERSHKNLVEDNAFMRKQYDEASNRAVEEVQQANLLRDQVKQLTGQLKIGLKQREIFNATVAAQRNDETCRLRAQIKVLLDQSRRTDDDIRHKAQFYKKYKAEYDNIVRTASEQSDKIERLEERVGTLVDKLETLRAVKMGAFDVDESEDENGDGRKGVSPLRFHTPQKGVAAARLPFPATSDNDNVFGVQVQREAQAIGPVIKEGGEGYVCKWRVGDEACQVVCDTVEEIHTHAIAHQREELEAKGIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUT0</accession>
    <name>A0ABR3BUT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102606</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614620.1">
        <property type="nucleotide sequence ID" value="XM_066757151.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989463"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045156">
        <property type="entry name" value="Vac8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="168"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="209"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="252"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="293"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="334"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="518"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="572"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="627" mass="66954" checksum="C1B2CD7D86AA7742" modified="2025-10-08" version="1">MGNALSSCCSPRRKNAYEPLLLETEREAVADLLQYLENRSTTNFFAGSPLAALTTLSFSENVDLQRSAALAFAEITEKEVREVGRDTLDPILYLLSSHDPEVQRAASAALGNLAVNAENKLLVVSLGGLEPLIRQMLSPNVEVQCNAVGCITNLATHDENKTQIAKSGALVPLTRLAKSKDMRVQRNATGALLNMTHSDENRQQLVAAGAIPVLVSLLNSPDTDVQYYCTTALSNIAVDAANRKKLAQSEPKLVQSLVQLMDSQSLKVQCQAALALRNLASDSKYQIEIVKFGGLKPLLRLLHSSYLPLILSAAACVRNVSIHPANESPIIESGFLQPLIELLSFDENEEVQCHAISTLRNLAASSEKNKGAIVEAGAVEKIKSLVLTVPLAVQSEMTACVAVLALSDDLKPQLLEMGICEVLIPLTNSPSVEVQGNSAAALGNLSSKAAEDYAPFNAVWNKPDGGLHAYLVRFLSSADITFQHIAVWTIVQLLEAEDEQLTNNIRSSPILISSIRQLAKSPPPSRAGGAPRRDPNDPSAGSSDDEFEDGLTDQEGEGEIVSLARRILDLTEVGEGDEFGERGGRNVPVSSHGQASGQGQTSNVGSMGSEHAALRASVHRALSGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUW9</accession>
    <name>A0ABR3BUW9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614922.1">
        <property type="nucleotide sequence ID" value="XM_066757453.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989807"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06105">
        <property type="entry name" value="ScCit1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="464" mass="51001" checksum="500A675E9AE5892C" modified="2025-10-08" version="1">MSFIASRNALRSQLRPSLARTFASTPAAHAQSLKDRMAELIPQEIENVKATRAAHGAKSLGDVTVDMAYGGMRGIKGLIWEGSVLDPNEGIRFRGLTIPECQQKLPSAPGGSEPLPEALFWLLLTGEVPTDEQVKGLSQEWAARAAIPKFVEELIDRCPNTLHPMTQFAIAVNALNHDSAFAKAYSNGVHKKEYWKTTFDDSMDLIAKLPNIAGRIFRNVFGDGKLPPIDPSKDYSANLATLLGFGDNADFVELMRLYITIHSDHEGGNVSAHTGHLVGSALSDPFLAFGASLNGLAGPLHGLANQEVLRWVQKMRSQIGEEASDEKVAEYVWSTLKSGQVVPGYGHAVLRKTDPRYTAQREFALKHLPEDPLFKLVGQIYKIVPNILLEAGKAKNPWPNVDAHSGVLLTYYGLHQQDFYTVLFGVSRAFGVVSQLIWDRALGMPLERPKSYSTEAIKKMFEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV58</accession>
    <name>A0ABR3BV58_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocon-associated protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102731</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614740.1">
        <property type="nucleotide sequence ID" value="XM_066757271.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989587"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="26984" checksum="1E6ED361D13F5BEB" modified="2025-10-08" version="1">MGIFTHSAEDDVLVSASFPETNAFGNVVNGENNNILLHLINSGSKNYTLVSASASYHDPANHWALVKNATTLKYGVPLVSGANFSAPYHVYSEFRPQELGLTVTVNLAETGTKDLHSITAMNRTVSIVEAPGSWLDFQLIFLYLILGTALTLGGWWAYDSYLAPKSKGKGKKKSGLGPKKVQAVVPGKESVYPEVKPYEEEWIPEQLLKNKQNKLKKRNVDGASSAGEVTSGGETSGAEGKGKKRKGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVC6</accession>
    <name>A0ABR3BVC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_103068</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613953.1">
        <property type="nucleotide sequence ID" value="XM_066757569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989924"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013958">
        <property type="entry name" value="DASH_Dad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08649">
        <property type="entry name" value="DASH_Dad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0249766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="106" mass="11514" checksum="E5B87CA81035EC9D" modified="2025-10-08" version="1">MSLSRPSNAYDALAPSESFFEREKARLIEEISTNFEELMGNMNTLNRTLEQVYGVGREFTMVASLWGRFSTLIKEQQTELATSADVGVPGTGGANFAASASTPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVG6</accession>
    <name>A0ABR3BVG6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquinol-cytochrome c chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615105.1">
        <property type="nucleotide sequence ID" value="XM_066756328.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988634"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="3">
        <location>
            <begin position="130"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="352" mass="39981" checksum="A70092A4E911E4CD" modified="2025-10-08" version="1">MRAPALRPLGQLQLRQLNSSIRPLHSAPLLLAAADSHSHSHSNSKKSKTKFLTDRPVKVDRTPSFPPPANPFAPKPEPVHYSDLTLSILWKVNKLLGYNGRRRTTARESGRMMSGIIEAVKHDKAFWYDECDLPKTFHTFFSVHLVYLLITLIRLRALSNHIPNPYSPIPQSALPGQPGTTTPVQRPSLMDRFEDLVSPAHEYKYRQTLLTHFFHIVENEIRLMLGVEITRDSAVQSRMKDYANWWREAQIGMDYVLGLTASENPQERAVADAELASWVWRLIFGRRGEGANGQGELVYPEGEALKEGKELEMAEQVEAIVRFIRREMARLDKISDRDVIAGNVGIFGKVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVL2</accession>
    <name>A0ABR3BVL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102952</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614923.1">
        <property type="nucleotide sequence ID" value="XM_066757454.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989808"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="43725" checksum="EAB735DB7B11483E" modified="2025-10-08" version="1">MVADTTYYDLLEVSVDATEVEIKKAYKKKAMQHHPDKNPDDPNSHETFQRIGQAYETLSNPNDRATYDQYGVDGPPRGGMPSDMDMDDLFSAMFGGGFDDFGGGMGGGFFDPSGGRGGGRRKPSKGRDTTVPYDITLEEVFKGKKVMMSIERDRVCGGCKGSGARLGVTPKECSKCSGKGVVFTDRMLGPGLVGKVKSPCPECNGEGVKLRDKEKCKKCKGQKVVKEKKRIEFMIEPGTEDGERIALRGEGDEAPDIPPGDVIFLIRHLPHPSFRAQPHSPGSLTILLSIRLSEALLGFSRVLFIHLDGKGVHVTSKKGERVIQPGSVWVIKGEGLPIRGKGKRGDMYVRFDVEFPTADWAKGVEIEGGESTKVELPGRKPDLGLSPEQIVVRELSDKPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVL6</accession>
    <name>A0ABR3BVL6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615165.1">
        <property type="nucleotide sequence ID" value="XM_066756388.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988695"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="4">
        <location>
            <begin position="42"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="5">
        <location>
            <begin position="439"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="496" mass="53532" checksum="AD046F07DBB38F3B" modified="2025-10-08" version="1">MLSRSLRLTRTLPRVSVASRVFSSTSYIMAEQKFRKEKDTFGDLQVPADRYWGAQTQRSLMNFDIGGPTERMPPPLIKAFGVLKKAAATVNQTYGLPADVAANIQKAADEVISGKLIDEFPLVVFQTGSGTQTNMNVNEVISNRAIEMMGGELGSKKPVHPNDHVNMSQSSNDTFPTAMHIAAVVEINEQLLPAMKELHAALKAKQDAFEHIIKIGRTHLQDATPLTLGQEFSGYVTQVERGIGRVEATLKNLSMLAQGGTAVGTGLNTRKGFDEKVAAEISKITGHEFITAPNKFEALAAHDAIVEASGALNVVAVSFMKIANDIRYLGSGPRCGLGELELPENEPGSSIMPGKVNPTQCEALTMVAAQVMGNNTTISVAGSYGQFELNVFKPVLIKNLLQSIRLLSDGARSFTKNCVVGIKANEDKIKKIMNESLMLATCLNSTLGYDDVAAIAKKAHKEGLTLKESTLALGKLTSEQFDEKVRPELMLAPTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW25</accession>
    <name>A0ABR3BW25_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Upf1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_101975</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615303.1">
        <property type="nucleotide sequence ID" value="XM_066756526.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988833"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="12">
        <location>
            <begin position="76"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="11">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="11">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="11">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0252583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1084" mass="119146" checksum="ED3057AE4D49B5F4" modified="2025-10-08" version="1">MEFPNFEGASQYGPDIDDNTSLYSSIPPSVVTAPTISGDIASQLGDLHLGETTSGHAAVGQGYIDDFDEEIERNSFGEGVEHACNYCGIHNPQCVVKCLHCNKWFCNSRGNTSASHIVNHLVKAKHKEVILHKESALGDTIPECYNCGSKNVFMLGFIPAKSDTVVVLLCRQPCAALTSSRDINWDTSQWSAIIDDRQFLSWLVKVPSEAEQLRARQISLAQISKLEELWRENPNAKLEDAEAQSGEEEMQPILLKYEDAYQYQNILGPLVKIEADYDKRMKESQTENDITIRWDMGLNQKRLAWFCMPKLESGEVRLAVGDELKLKFAGTTNSVGIKGLQAFNKGGWGSSGDAVWEGVGSVVKIPNNASDEICLELRRNDGVPFDCTHGFSVDFIWKSTSFDRMQAAMKTFAIDEKSVSGYIYHKLLGHEVEPQVLRTQMPKRFAAPNLPELNHSQMSAVKAVLQKPLSLIQGPPGTGKTVTSASIVYHLAKMNPGQVLVCAPSNVAVDHLCEKIHLTGLKVVRLAAKSREALDSSVDFLSLHSQVANADTHHELQKLIQLRNDQGELSQSDERKYKALVKACEKDILNAADVICTTCVGAGDPRLAKFKFRTVLIDEATQSAEPECMIPLVMGCKQAVLVGDHQQLGPVIMNKKAARAGLSQSLFERLVILGNHPIRLQVQYRMHPCLSEFSSNLFYEGTLQNGVTAPERLRKNVDFPWPVADTPMFFHQNLGTEEISSSGTSFLNRTEASNVEKMVTKFFKSGVLPNQIGVITPYEGQRSYIASYMQLHGSLKKDLYKEVEVASVDAFQGREKDYIILSCVRSNEHQGIGFLNDPRRMNVALTRAKYGVVILGNPKVLSKHPLWLYLLSHYKEKGCFVEGPLSNLQPSMVQFSRPKKSLAAAMDPFKRRETSAAEFLSKNVGHGHGQGHGQSSVTSRFDPAYYRTHNPLSFIPPDAQSVVSQALTSSAFPLFGAEGGGVGGKNKTYTGYASSVISQQPMDSGTAQGHRVAGQSQFDRFANVGGDNMMGMGMGNMMGMGMGKGRRLSIGSEAASASMYAYGYKAGEDDTQSIAPSQAGMTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW50</accession>
    <name>A0ABR3BW50_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615081.1">
        <property type="nucleotide sequence ID" value="XM_066756304.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988608"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="558" mass="60064" checksum="F3841BE6A9A3E492" modified="2025-10-08" version="1">MASTMYQRDPRAGLFLGGSRTSGAEVRDANVMACQTVSNILKSSLGPVGLDKMLVDNVGDVTITNDGATILSLLEVAHPAARVLVSLATQQDKEVGDGTTSVVLLASELLRRANELVRNKIHPTTVITGYRLACKEACRYMAEQLSTKVDKLGKDSLINVAKTSMSSKILSADDDFFAPLAVDAMLAVKTINAKGEKKYPVKAVNVLKAHGKSARESFMVKGYALNCTVASHAMKTRITGAKIACLDMNLAKQRMHLGVHITIDDPDQLEAIRARESEITLERVRKILASGANVVLTTKGIDDLVLKEFVEAGAMAVRRCRKEDLRRIAKATGASLISSLANLEGEETFEASSLGYAEEVVQERISDDELILVKGTKIVNSSSIILRGANDFMLDEMERSLHDALSIVKRTLESGSVVPGGGAVETALSIYLENFATTLGSREQLAIAEFAAALLTIPKTLSINAAKDSTDLVAKLRAYHNAAQNAPLNDPKRGLMYYGLDLLNGEVIDNRQAGVLEPTISKIKSLKSALEAATSLLRIDDSIQVAPEQKEEVDPHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW51</accession>
    <name>A0ABR3BW51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Capsular associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614859.1">
        <property type="nucleotide sequence ID" value="XM_066757390.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989711"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047484583" description="Capsular associated protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="62553" checksum="A21589F3DA235143" modified="2025-10-08" version="1">MISLGSSRRPHVFLAIVLSLALVLFLHAHPHPQSYFLSGPISKLKVQFGLYNASDGLEKKDKRIRERVERMKGYCEVEDAFEREYGRTNLRLARGYEGSHERMRLLLQKIMRGEPLTISAIGGSVTKGHQVWDNEIWFHKFWEWLTEFAGEDVEIKEVNGAAPATGSDYFSFCFPLHIPSNSDLVLVELAVNDEGIPEHVENMENLLRGLLDLPSKPAVMLVEAMAFSNGGMGGGGGRMHLPVAQYYDVPVINQRLPLVNHFARHPQLVRPYFAQDWWGNPDTRHINSHGHRDLGMLVASFVKDVACEMFSEPTFHVQPPSSFEALSIVALAQPPQTEDKEDADAEDELLASEQKRWPEQSRSWRKNSTEEQPIGELMPGLWSSPIEYGMLPRLRVLEGWNPHLDYSVPPFHPTCLSTRAREPRFNLTPSANEGWEYWVHPEHLDKPYLIARTPGARVSFELETSVGIVKMYALKSKTFGLGTVECWVDEERRKSVRIEGYWDNGNVNIGRFAPIRDNLQPGKHTVTCELLEETSDPGGGHEFRMISMMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW76</accession>
    <name>A0ABR3BW76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">IQ domain-containing calmodulin-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615111.1">
        <property type="nucleotide sequence ID" value="XM_066756334.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988640"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250:SF27">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="71728" checksum="B0ADDBB5F8B4657E" modified="2025-10-08" version="1">MPCSSPPLSHAFFTAVLPPTSQYRHLDFQITPARAHEMDPNNVVNSEIDAKYSSLGSRPNTMTAPVDASVPYRDTEREDETAANKNMQAGTEEENEKAGKAAVIIQKHYRGHVARKHVQELRLRREARWNDLVKHSQEVTYAKGQLDNKNDVVSRWRRAAHAASRLQTGDGLFSSPIAALPSSQVDECDPTKLTDKELRARKATFWGSLSLGVGKNRDEEKELPFHSKELETQHWLEMIDGKHRYGSNMKYYFRKWKEADTSDNFFRWLDKGEGKDLDLEEMPRERLEKERITYLSAEERLNYLVEVDKDGLLRWAHNNEFVDTAAGRWKDAGDGTGIVPADPQSEEDENKPKPQPTIDPYAPPHNQRMHKVTRASSLSSLSSDSYSPQSSELDENESTHYVGLDQKPEGWLERQKKRLTPGGVRRELLRKTVRRNTWIYVSDMKLNLFVGIKHSGTFQHSSFLAGGKVTSAGIIVVKQGLIKSLNPLSGHYRSSIDSFRSFISQLESKGVDLSHVKIAKSVLSLWGLSKYSRMTKAQNNLITHVQRTLHLSHEPTEEEKSQELQENAEREEREHQERMKVVMEAEEEAKESGQMRDNKEGAATEKDKEEMRELRREVLYGRRRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWL0</accession>
    <name>A0ABR3BWL0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615482.1">
        <property type="nucleotide sequence ID" value="XM_066756705.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989012"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0252762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11826" checksum="6EAA04F54272416F" modified="2025-10-08" version="1">MHHPFFSFSSSTLLCRISPSVLSFEEVPGGYRRSWRYGTSWPFEESLGDTVGRSGLSDRRSNKSRFTLQCPTNENGKLLIALVRFMSDYFTFTTLTVGTAYCYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWW5</accession>
    <name>A0ABR3BWW5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_102272</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615600.1">
        <property type="nucleotide sequence ID" value="XM_066756823.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989130"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0252880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="242" mass="26735" checksum="886A8BFB0D5D17A2" modified="2025-10-08" version="1">MPPKAQMAPISRSNRPTIVGADEPEAPYPLRLEGTVTKGFGRGARYLGIPTANLPDESLGPLNDLGLTGIYYGFARVHHSLSTPLPSALPTPVVSKPSTPGPEGKKVESEAQLEVLPTITAPYPPEHHAQRWSKEDEKVWPMVMSVGWNPYFKNEKITAEVHIMHPFKADFYGHHMSIVILGYIRPELDYVSKEALIDDIQTDVKVALNSLARPKYAKFAHDEFFLKQSLSIAGQSQNNLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWY9</accession>
    <name>A0ABR3BWY9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615617.1">
        <property type="nucleotide sequence ID" value="XM_066756840.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989147"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="138" mass="15695" checksum="F085282C2AFF2972" modified="2025-10-08" version="1">MSSGVQPTQECIEKFQELKTGKKLAYVIYGLSEDKRSIVVLKASEDKDFDSFVAELPEKDCRWAVYDYEFTLPGGEGVRNKLCFIVWSPDDASVKSKMIFASSKDALRRRLEGIHAEIQATDFSEITKDVVFDKVTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX55</accession>
    <name>A0ABR3BX55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615685.1">
        <property type="nucleotide sequence ID" value="XM_066756908.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989216"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="212" mass="24308" checksum="94CBCFC96DFBD6DB" modified="2025-10-08" version="1">MANPRQRNKAKSSRSHKPSLNAKRRMHQKLRKAPPLKGPEVLQEKWDKKKTVFQNYAALGLLPSIPVPKGASTSRSQRVKLPEVPAEIEAENVKVGFGRIIRDEERNVIDIIIDEDEQEQEEQIEVDEEKEMGPVEAKTEVVKRLEELAASAAPVKRHSSMSERTWLQQLVDKYGDDTEKMARDRKLNVWQKTEGEIKRMIKKAGGVQLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX65</accession>
    <name>A0ABR3BX65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_101857</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615185.1">
        <property type="nucleotide sequence ID" value="XM_066756408.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988715"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="29"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="453"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="639"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="674"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="822"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="852"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0252465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="877" mass="96146" checksum="EBA4996C03DF6EAC" modified="2025-10-08" version="1">MTAFHPFEVTVPHLAYAFLGGFVVIFGMVSLFVKEKLYVGEAPIATLVGIIIGPHCLNLFNPLGWGGGSETVADDITLEVTRVVIAISVFAVGVELPKAYMKRHWRSLFFLLGPCMVWGWMVSALLIWGLIPDLTFLASLVVAAGVTPTDPILAQAVIGGKFADKHVPAHIRHLLSAESGSNDGAAFPFLYIALYLLLDASPGHAVGEWFYMTWAYEIILGVVIGAILGFCARKFMKFAERKRLIDRQSYVAQYVSLAVLSIGVTSLLGSDDLLSAFACGCAFAWDGFFNKATEDAVFSNVIDLLFNCAAFIYIGAIIPFNNFNDLPDLRVWRLVVLAILILLVRRLPSIIACYKFIPDIKTFREALFTGWFGPMGVGAVFISTLARSSLPEGEPDKNTEAVDRLKAVIMPVTLFLVLSSIVTRQEIIVNRDDDDEEGDLGVRRKDTFTSEANGRIKEKIEEEDSGESSSSRTRQGELIEMKEKRSPSRRGSRGSQASQASQGEAAEEGERWRSSGEGSSDVANDPETQREVEEGREEIRDKEGGGRRTPTLAKYREGNHLIVERKIKDSDEVEVEVIRNHFADNKKTESDRFTHPHRLKSRELDDLLHHLPKSLEHATSRVQNGGKDAVDRLGLGLMATVTPEPTPPIESHDSPRHDYGYPLERTQSPEDLAEEGRDGESPGDVSHEGAYEEDEADYEDVPDETPRQTKKKMKPPAIVVSRQNSAGPPRRSIRSRLFGRRQQSSNSSSRAEEGLAPPNPSLLAPSPSLSRPQTIAAEPESILAEDSRGSSSSSQPQNLAIPLTRTLSASRSSPAVRFADDTSPSTDTAPGQSNYGSNAPGFKKNPALAMYRSTSVQSTGSNKDGPSVSFVEPEIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXU1</accession>
    <name>A0ABR3BXU1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615666.1">
        <property type="nucleotide sequence ID" value="XM_066756889.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989197"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="215" mass="23866" checksum="9E16434F64A0E8F3" modified="2025-10-08" version="1">MTTSAYSDLIGRAEELVKTHMAKYDPSHDWPHVDRVRKMAMTIARSMDNAPDLLVVELAALFHDLSDKYAKPGSPTLSDMLFPILQPQIPNETIERILSIIPCVSYTAETALLAAGEWTWQNDCLELYAVQDADRLDAIGAVGILRCAAYSGATKRVLVENGDTGGKSAEAHFEEKLLKVRDRMKTAFGKEEAGRRHQTMVNFLASLQAEKECLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYJ5</accession>
    <name>A0ABR3BYJ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615311.1">
        <property type="nucleotide sequence ID" value="XM_066756534.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988841"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="893"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1020" mass="110226" checksum="D63B106F0BE7CE01" modified="2025-10-08" version="1">MGQATPPQHLVALLSNPHTPANYAADALEEWIAHRRAKGDSLFHISLALAHLEDIVSAPPLGPRSHLQTPPHTAHVLDRARYLTNVPQPQDLTPPVGLFPLARSASIATILSHLLATPPPSIQHSREVVLEYVLSREAKLKEKKPGRAGKGTLGREAFEDIAKRMGELEDSLRGNPASSPSTSPSRDAYPSPRRSPRQLQAQLLNENQQIGLTLILSLRMSLSYFTLQELANQLMLVALGDAERMLIQHIRRRVSGEGRWGVGKELEYVERLTLSRRPALRPAFRSAKARTLLPPEPLYPIQLPAPSKSQCIKQIQALAKEIEAGGPAAGQEFLHVHAPSGIPAPIFNTPNSEKHFLGRRSANTSPTVKATLAREGSPQTPLSNLPPALDSPAFSPARTSQPDPNMLPNFTMELISEYITREKREQMLKFKWAKSGRAQVSKDLGEIEAALCLVSKSKASSIAPLLLPTFLLLRRTFALPPSPLSQAITEPYIDILPAPPDPDDVPFREPTVSSTTAALYVNPRLSDDKAYDALEELAEFEKEKVDGAGGTRQQMAEWALSQIEAVQKRFPDGSYSQVFNRMKGNLLQQRRPEEHYQSISFAKSPSIHRRVKSNAAENGSPVAVDPLRAQHTRSLSMPDRKASYDSDFNSEEDGHENASVIQSSPPIDQPSLPTTTAVSSSKPLPGIETSVPQLPPLMLTPGDDGDRRSSAASAGAAPSSGGGGGAGAGGWWDVVSAVAKEDSNSNRAPWDTTPEKRSSGRMSHMSQLSTTSSHRDRLTLSVNEPARNIVAAPLPPGAEPAQALDFTRPMMNLDLNDSPVSQAKPPFSAPVSPRREAQYLPGQTVRSAGATESFAPSSPPYGYVPQRKDEDEDLPPPPPLRFDQSRNGHTLGSSTTPSNHSSSFTTESTPTPTAFSSSILSQGISYPTSSNPSLAAAVAATPPIPHPAQTPASSSSSTTKSKLGSFGRSMSLARGKSKKEKEKDGEKEGKDKSNKKEKVLNDPGKWNRDLVANIMGPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ20</accession>
    <name>A0ABR3BZ20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,3-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615855.1">
        <property type="nucleotide sequence ID" value="XM_066755569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987867"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF1">
        <property type="entry name" value="CAPSULAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0253634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="58527" checksum="0B340FEF09B0765B" modified="2025-10-08" version="1">MKPVVSLSLGRKLPSAGSLLVGILVGLLVASLLRRGDLRPNPVSGSSRLQRSQIMLPSLEQRLHILDLISTLSAHHTKECLRNPQPLYVEQVKERYAPLVGYKRPWSNAGWLRRLFGGSDSHSTMASITGNDRMDTIKRDLQARQHKYFFAINLYNSFDVIPDIFATLFRAAAILGYHNVFVSIYENGSNDQTKALLKIFDALARTVGLRIIIRTSMRTRGLFNHRIEYLAEVRNAAMLPLHELRDNDGEVFDSVVFMNDILPCVDDLLELIWQSRRQNAGITCAADYMYHDDIGAPVFYDNWVARDINGTALENAPFEQIFHHTESNHRFQRHLPIQVQSCWNGIAVLDPTPFYEPPHVRFRMANLAQGECSASECSLICNDYFNAGYGRIIMVPRVKLAYDRKVWDIIHPERRNLTAIRGYKRIGGLPDDPHSDPQDRSWYGPHDRLFTPEETEELEFVPGPEYVWCWGWDGAGDLDGPDVDPIWEHMQPRSYSEEAIQIKHYRNMPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ51</accession>
    <name>A0ABR3BZ51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_101941</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615269.1">
        <property type="nucleotide sequence ID" value="XM_066756492.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988799"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="338"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0252549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="697" mass="75809" checksum="09651F78002949F7" modified="2025-10-08" version="1">MDRTMSGIILLSTAGFLAFCMIIDHPRFLARLFASFFDPKKAKVKQTPKTGLHTSLDPQDHSTEKVTGGGDLREGWFLKKEINRHIELLSPRTPTSGRCGRFSPWIGENESQEIRPGLSPFLQPPPHIPPLISYLPFSASLLCTPFNRLPEPFKSIITVKQIYIILGYVLLTAFALLWGSKLSPAEKTSGYGSDFKPSGHVAIAQLPVVIALGVRGNVLGLCVGQGYEKLKLLHKVTGRILFVAASIHMIGYTYMWLAAGRFVTSSSQRYAVCGYLSYAAMLLVTISSLPYCRRAYYELFKICHLVGMVVMLFGLAWHVNEAVPFCISGLIFYLTSFAGSLAKTRLAKARLHALPGSSTTIVTISALKSGWRPGQHVRIRILALGGRYGFEGHPFTISSASNGEGMVLMCKNAGDWTNRLFNFSRALEASTCEPEAGSGRNVTIIIEGPYGGTGNTMLSSFSSLVLIAGGSGITHALAIAHDLLKRAPTGAVRARTIDLVWMVKTEQEAKPLMATLLELVSDAKSWEDASVEGRRRQSNYASPTALRIQIFVTRCPASSPLTLVPDATVLSGSNVGTGSRNSDMADDTSGANREKVAYLSRNLSSASTMSAMRDKNPQLSGITARPARPNLNIVISKIADDTIVHHRRRLIEASGMYVTACGPESLVYSTMQAVKALEAYKQIAAGGVEFEEERFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ73</accession>
    <name>A0ABR3BZ73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615284.1">
        <property type="nucleotide sequence ID" value="XM_066756507.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988814"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="415" mass="44881" checksum="DFB3D44E8ED9FA31" modified="2025-10-08" version="1">MAHPLTQQPSSTISFPFAARPSPLTFGFGLPPAAPSEAPTHMSSAHSPNRITGPACSSPSRNSFARPRPSQAFTPPTRSLKRTRRSRSPSTSPAGSIQSPRSHSPTPVSSRLGSLPSPKGLRTDLSHAPKAVKRSKLQNCTSDEQSAEGVDIGIMLAALPPSAHLPILLQLMQLEPSLSSTVLGIMPKLEFRSCLKEMERLFAEIEKLAGPVANISFYPGALAESRRWDRVSNHVEVYCRTVSTYIKCFTSSNQQPVIDCPTLFLFLESHTRHLLTILSYIPSSSQLDGSTPPPASLVLDLAKLSLTIWSSWVSDLSSDVNDKGGMYPHSVVTHWNDTLEQLVAGPPSLSSSVLPPSNASARGSHWLSSTPLTADANQPAKLLVSSFQEAFTPIRDQFVSQVGWLVGRQPSMEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZP4</accession>
    <name>A0ABR3BZP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_101231</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616074.1">
        <property type="nucleotide sequence ID" value="XM_066755788.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988089"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="246"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="330"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="446"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0253853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="520" mass="59576" checksum="C7457240DC26D5E9" modified="2025-10-08" version="1">MSVMLETSLGDLIIDLEVDKCPRTCENFIKLCKLKYYALNAFFNVSKNFIAQSGDPTATGTGGESLASYVYSQSPSGSRPPRYFTPEILNSLKHTHKGTLSMAVAPIDPPGCGSQFFITLADNVDYLDGKHAVFGHVIEGLDTLDKINDAFTDKEGRPLQDIRIRHVEILEDPFPDPDNFMPIPQSPLRPPDDLSKVRIADTEDPNAVIPEEEAEELRRRTEAASSALTLEMIGDLPFAAVRPPENILFVCKLNPVTQDEDLELIFSRFGKILSCEVVRDKKSGDSLQYAFIEFDEREAAEQAYFKMQNVLVDDRRIWVDFSQSVAKMNRSMLSSSNPTGRGGRGGRGDRGGRGGNYGGRRDGDRDRDRDRERDSGWSSRQSGPDPRRERTHRNDDRHRGSRGRDASDSRRAPPPAVPMSSSRDVRGTEGYGLVFDDESAPSSGGSRRDRERSPRRERDRDRVRSPRRDRDREEDDRDRRDRDRNRRDRERNGDRERYRERSRERENERYRERDDRDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C027</accession>
    <name>A0ABR3C027_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_101369</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616211.1">
        <property type="nucleotide sequence ID" value="XM_066755925.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988227"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="11">
        <location>
            <begin position="39"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="582"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0253990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="880" mass="99825" checksum="7F5B3A5975A849FE" modified="2025-10-08" version="1">MQPGPSKDRDYSFARLCHLTPHLALKITSLQGSLPKHPFSRTLHNPDLAHQGIQQQTPSDLYVTCQLWADGKQYSLLFRTPHKDFPRGYTWNSVVIFPITYPSLLLSSQIAFTIWDVQGSGKAIPVGGTTMSLFNSNRTLKRGQQRLHVHRGVQADPSLNTTTPSELADKEEDEMGRLERLVKDFERGDIPKIDWLDRLTFRQIEKAHSVEAEKSDNLYLYVDLPKFDFPVVFSEQESLITLPTQPVVHPPSQNSQPTSALPPNLLSNDPHLWKTYDPEAWRENPVEIKHRKLLRSQRLGDEGRDLKPGPVDRDRLNEIFRLPPTASLSAVDKDLLWKFRFSLFRSPRSLTKFLKCITWSDPVEAKQAVEKLLPLWGQEVGMDDALELLGPGFTHKKVRAFAVKRLERAEDDELLLYLLQLVQALKFEHKSSLDTQPGHRAHRKRERELASQDEQSSGLSQFLINRSVANPILGTSFHWYLMIECDNRSSVGKMYAQVAFNFMKKLSETPEGQAQRDILRRQGELVQILSTRAKEIRASKDSRSKKIEKLKAYLSDSKHGLASLPEPLPLPLNPNVFVTSVVAEKSSIFKSNLLPLLIWFETIDSVRSTDDDSPDVVVSITPDYPIIFKNGDDLRQDQLVIQLFTLMDRLLRKENLDLRLSPYSVLATSTTEGMIQFVPSKSVASIMAEHGSLQNYLRIEHADDGALGSYGIEASVMDTFVRSCAGYSVLTYVLGVGDRHLDNLMLAPDGHFFHVDFGYILGRDPKPYPPPVKVCKEMVDAMGGPGSAHYGRFQSLCYTAFIGLRKNANLILNLVALMVDAGIQDIQLEPDKAVWKVQEKFMLDLSEEDAIKQFEVLLNDTSYLTAVFDRIHDWAQYLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0B7</accession>
    <name>A0ABR3C0B7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616303.1">
        <property type="nucleotide sequence ID" value="XM_066756017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988319"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057357">
        <property type="entry name" value="Znf-C2H2_ZFAND2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25403">
        <property type="entry name" value="zf-C2H2_ZFAND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0254082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="322" mass="34608" checksum="F214701BB8AA2ED1" modified="2025-10-08" version="1">MTTSTPESRSEMMFLGQECNHPACYLHDFLPFNCPACHLAFCQPHFLPSQHPCTAPLPASMVDRIAPTCPVCNEIVPYPKSMDPNEAVERHIMSGTCVGLQGGEERKKAEAKRRRDVGEVCWKKSCGKVLIVKMMCESCQHVFCPTHRHPTSHTCSDQTPSPSSSSSRLGNPQTPSTSRPAGKAALSRLLPPSMQPPASSGASTSIPPVKVNSANITLGGSKPLAASSEGNVRSNLDAKAAAAAAALKRAGQDVKVPFVKSSAEKRTQAEVNSQIQALKARHEKGLLTKTEQVKYAELVGQREPTRRTGGKSKNKDKDCVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0B8</accession>
    <name>A0ABR3C0B8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616305.1">
        <property type="nucleotide sequence ID" value="XM_066756019.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988321"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018852">
        <property type="entry name" value="DUF2456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10445">
        <property type="entry name" value="DUF2456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0254084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="63968" checksum="DCD78D51115B8316" modified="2025-10-08" version="1">MQSLLLPFPSPLTGKQWFYLLFLQGVGAGIIDGGANFGIAYAMYHNQKEIKMWVLAKNTIAGDLGVTPIIQCLASMLITSTLVHTDLHHHAVAPLPYVWPHVEHLPDPRILLDKIFRRKDVVREKTEDEKGNMNYSSSGSEIEGHKGWLYYPNMLVRFAFEGTEANILFSPFKAKLFIFKAFLTAAQGALLGIFCGLPLWCLFIVVLGPIYKNDNMAETGWKWAPMVIKCVYGAVLGWVTNPIIAGLALGSQAERHLLVIEHDEESVAENASQIVDVDGVPTILEEDELTPPQFPPSPHASLSHSSRLSPYPSPMSASRVLPTQNVNRPRTRSRASTLSRPPLTANCSDLPIIPSRSLNAPQYSGGEALALPKTAPLVQTGRMRSLSQATAQGAGAEAGAGAGTGSTSFGTPARTAVPAVGTPLTGPRETFAPPSPLPYHTIMTPSGPRRRGLTMSTAYTASSSTNGNNIAGGIAPTSTGVAPGTGGSGWSYALGGTGGRNQRRPRASSSLSGKGGGKEKILGELWSKSAIPMGASGTPAVTAAGEEEEVLAEDADRSGEVREGEGEGKRVPAWDVFGIVQGAERGSQAGNKSGEKKEGEEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0E1</accession>
    <name>A0ABR3C0E1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616100.1">
        <property type="nucleotide sequence ID" value="XM_066755814.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988115"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="191"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="291"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="439" mass="46445" checksum="8D33BB51E8F0A822" modified="2025-10-08" version="1">MAKSAKSAPASTVKVDKKDKKSKKEEKPAASPAPAKAAKKDVKEKKSKKAKTPTPPPESSSSESEDSEEEDSSDSESSSSEDEKPAAKTAAPVAEAKKEESSSDESSESSSDSESESEEQPKAETKKEASEESDSDSDSDSDSSEDEDEKMEETKEEAKPQANGNKRKAEEESVSPAKKARPDDGEEEATTNVFVGQLSWNVDNDWLKSEFESCGEVVSARVVFDRDSQKSRGFGYVEFADLEASAKAIEKDGSEIDGRAIRVNYATQRKPNEAAEKRAKVFNDKQSPPAETLWIGSLSFSVTEDQVYEAFGQHGDVQSVRLPTDRDTGAPKGFGYVQFSSVEDATAALKAMNGAEIAGRAIRVDFAPPKQDNGERGGFGGGRGGGGFGGRGGGRGGGRGRGGFDRGGRGGGRGRGGPPRGGARTGGIVKPEGQKVTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0G0</accession>
    <name>A0ABR3C0G0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616298.1">
        <property type="nucleotide sequence ID" value="XM_066756012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988314"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="7">
        <location>
            <begin position="92"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="310"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="352"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0254077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="622" mass="68854" checksum="047237BE757EA11F" modified="2025-10-08" version="1">MSSGEQINAAGPSRQQALTTESRSLITARQREKAPQLEDVALEEGLFEQEIDLLIGQYLECRGASKAARIWDEQVLGRGANGSTRKEQIEDVERAILDGDWGSIENLIARPGLLRLQTQKAFLYLVYRQQFLEHVENRESQKAFNLLQKRLKALEHYQPVPYDFYSLSYLTSASTVHDAPTFRDWAGMGPERDRLVGVWKELMDAERGGGVEERRYIPPDRLRTLLKQAAAWQVGRVGRKTDDIVKIPTLLQDYRPLELPSKLLHLLEGHLANVKCVDLIGSTAQYVVSGSSDCTLRVVSTEDGSLSHILSGHSSRIWSCASSPSGETIASSSGDGTIRLWSASKGDCRGVLVGDGGDVYNVKWRPNREDQVVSASYDRILRSWDIETGKQLRTFSGHSQSTLAIAYDSTGNTIASGSKDKHVRLWDAVGGVCTNTMTDCLGEIASVEFDDEGKYLLVGCKDNSNRLWDLRMQRSVYRYTGHQNTSKNLVRCSFACSTSLVISGSEDGSVYIWEREGNSNDRRSNSLVPSTHHNELLAPDRKGSGGDLTDFNTLASSPAYYPPRDIVRNPTSFTRHGETTVRPAKVLVGHGEGAVFEVRWKEGKMVSAGEDGCVGVWGVETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0J4</accession>
    <name>A0ABR3C0J4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine N-methyltransferase 2</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101299</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616142.1">
        <property type="nucleotide sequence ID" value="XM_066755856.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988157"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017408">
        <property type="entry name" value="Arginine_N-MeTrfase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038148">
        <property type="entry name" value="Arginine_N-mtfrase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RMT2" evidence="10">
        <location>
            <begin position="134"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0253921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="382" mass="42344" checksum="CE8A5F3D6563852C" modified="2025-10-08" version="1">MDMDSAHLDPSLLTLAFRLIKAAETAPPSVLAGLLAEGAPAWFQDDDLGWSCLHYAAERKEPECLKVLLQGGAVWNAVDKWGRTAGEICLSLGDEEGWSIIRNEGIRSEMLHHALAGTSSPDATNNIVLRAEDKTSAGDNLVFLKSKLTWDVGKDGKERVLDADGNGVMMGWEEPLMVEHVRRLTEEHPKAQLGAEGMSVLNVGFGLGIVDRLFQGCDPKPSHHTIIEAHPQVLKYIRKKGVHLLPNVRILEGRWQDWLLDGEKVGDVLSGTPDGMGFDAIFVDTFAEGYEDLKAFFEVIPDILDAENGRFSFWNGLGATNPTIYSVSSSLAELHLEDVGLQVEWHDVLIPESMREEVWKGVRRRYWDLPGYRLPIAKMGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0J9</accession>
    <name>A0ABR3C0J9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616376.1">
        <property type="nucleotide sequence ID" value="XM_066756090.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988393"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0254155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="148" mass="16977" checksum="AD468FD8DE826000" modified="2025-10-08" version="1">MPSLPPLPVFRPYLSMSEAPPIRSCSQCRSIPPHDCLTRLCDHCKNLNRERQARYFRKKRGKEAQSTPKVTFPSWLLLKHAFTEAFENHASQKATETEPIRPLHFKSECVLDDGLRPVDNTPAALDTRLRRLGLFLASVDTGLAYRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C140</accession>
    <name>A0ABR3C140_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615712.1">
        <property type="nucleotide sequence ID" value="XM_066755426.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987721"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="11"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="6">
        <location>
            <begin position="435"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0253491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="577" mass="64597" checksum="142E17B6B01CEFDE" modified="2025-10-08" version="1">MSNSSGRPRYHFVAPRGWMNDPCAPGYDPQTHIYHLFYQWNPKSHAWGDISWGHATSRDMVHWEHMSTEPVISPDQPYDSHGVFTGCFYPKGPSGQDDQNSVFYTSVNYLPITWNQPYKRGCEGLAMAVSKDEGVTWTKQDHNPVLAEEPPDIHVTGFRDPFLAPWAAMDKLRGSGRTLYALISGGIHGHGPRTFLYAIDPTDLTKWTYLHPLIVDLPVNHVPSSKWAGDFGANWECTNFVTLHGDSGRVRELVFAGAEGGKERPWVEDYHTSHGAAARRVPRYSNWLFGRLGLKESENEVRMSVDIVGLLDWGVFYAANSFKAADGRTVLWGWLIEEDLTDSELAKKGWTGCLGVPREIFLNTEHGVVGALVTKLEAIKSVEVIDDAIRPSSGSTVLTLGIRPIQEMKSLRKAVLYECLPGPLKAHRTVLPAASLTCEIQAIVHVFESTESVSLVLRHNDDQSIRTSIVFRPRDETLTVEREYSTSRDDVNTCPEVGSHTLFRLRPKDATENSIEPLRLTVLLDHDVIEVFANDRFALSTRVYTAPEHTGLSLMSKGGGWVEDFRVWEMAGIGLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3T6</accession>
    <name>A0ABR3C3T6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GabA permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616567.1">
        <property type="nucleotide sequence ID" value="XM_066754666.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986945"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF3">
        <property type="entry name" value="POLYAMINE TRANSPORTER TPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="58945" checksum="20F818ABEC31ACB5" modified="2025-10-08" version="1">MSLQEDIRPASLRSDPADVAGSDGGHSNKKPTTSLTRIEAVGDAQPDTEFSVMGYTPQLKRNRGQLTIQTMLLSLFAVPFGISSGFYTAMIGGGPASLVWGFILVGCLQECVAVSLGEICSRFPTSGGPYYWSYALAPPSIRTMLSYVTGWLYMLAIWMLDLGTHYGTAILIVGAINIYYPDWTAPVWVTLVICYGLYILSTLMTWKGHRWVPMLDTVNAVFTGICLVAIVASILGIAAEGRRSASFVFTHYDWSYSGWGRGFTFCIGLLPGCFVMCGIGFISSMSEEVAVPTKQIPRAMVIGIPVAILSGLVFILGCLFTLPDIDKLLNAPGGSPMPVILATATGSKAGGVALLSLIISNAAIACIANQYISSRTTWSFSRDHALPKSRLWSAVTEHSQPRNALIVSTIIQMLIALIGLGSSSAFNAFLNVGIIGVDLAYGMPIAISLCSGRKLVRDAPWYAGFLGKVCNIISVLWISFSLVLFSMPIAIPVDAVSANYAPLVLVFFMGFSALWYIIQARKVYKGPPPVDFLVSLDIPELAEREDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C427</accession>
    <name>A0ABR3C427_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CBS and PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616657.1">
        <property type="nucleotide sequence ID" value="XM_066754756.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987042"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="86"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="153"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="262"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="344"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="6">
        <location>
            <begin position="498"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="427"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="75374" checksum="16AD99E6850B9921" modified="2025-10-08" version="1">MSRIPVPYGGLHNSLPHSPQPAHADNMSTSSPASDTRRKQSKRDESLRKKIESELSRKRPGSNTNQQSNGSKRTSKRAQKGTVAGLRPSPALTVPEGMSVADASQLCAAKRADCVLVVDEEEGLSGIFTAKDLAFRVTAEGLDPRSTSVAQIMTKNPMVTRDTTNATEALQLMVSRGFRHLPVCNEDGDVVGLLDITKVFHEALAKVERGSTATSQLSAALAGVQSELGPGLNHNPQAAAMLAYVETLRERMALPDLTTVIDTRSAPPTVTPRTTVREAARLMKERRTTAVCVMEANAGTSAVSGVSGGNVIPKIAGIFTSKDIVLRVIAAGLDASRCSVVRVMTPHPDTAPPTMVVQDALKKMHNGHYLNLPVVEADGRLIGIVDVLKLTYATLEQIESMNEDRSNESGPMWSRFFEGLPGAGGDDDTASIVSASERPDTPSRSHLGHGRGLSSMTSPISEIMPNDSASVVDDNISDLGGKHGPASSVAAPALPVDDGTYIFKFRTPSGRTHRFQARHDSYELLRDIVAGKLLTDPFFTAPGAKEGEAVHLPDPSNFTLHYTDDEGDLVTMTADSDVADAVRIARGQKSDRIVLLVDGGKVWEEAARDLGGEKAVEKLKEVEQEVKAVEEEEKQMAQPTADPAVEPTYGNEHVHAQQWKDHGRTFRADGQELVGGIIPKDMVLPAAIGFLGVVILGVFIAGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4A9</accession>
    <name>A0ABR3C4A9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_100268</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616741.1">
        <property type="nucleotide sequence ID" value="XM_066754840.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987126"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0255464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="226" mass="26203" checksum="7C4951F0EA2653E1" modified="2025-10-08" version="1">MAQVVPSLDHPSSYRDSRSEIDRETERRLLAQSSTLYIGNLSFYTTETQMYQLFSTCAKPEIGGGIKRIIMGLDRNTKTPCGFAFVEYFLHEEAVDCMRYISGTKLDERVIRCDLDPGYKEGRQFGRGRSGGQVRDEFRQEYDSGRGGWGHQRLEEERRRQEQDRLRSQMQFDTYAAVGGLGLAGADVPRGEDFFADRQKRGRSEDEEEIERREDEKRLRGERDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4L8</accession>
    <name>A0ABR3C4L8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616852.1">
        <property type="nucleotide sequence ID" value="XM_066754951.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987238"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24868" checksum="80C70C311F4F12E7" modified="2025-10-08" version="1">MARPAAEILQTTGALRQLRRLGVATRSCYGARHQHQSTPSPARRPSPYRLLQPHAFLADFAPLHVSGWRVDALESSEKLLEADRVEEVLDGAQAMERGDLQGRRLVRVFELGEGKEGWRRLIKFVGHVGQVVGDQDHHPTIHISSLSDYISGSPSLLSFQTQSQSRTGYIVEISTHTHTPLPPYPLPTKGNKMKPGVTGKDIKLAQKVEEVYGELIGKVEVKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4U8</accession>
    <name>A0ABR3C4U8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616930.1">
        <property type="nucleotide sequence ID" value="XM_066755029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987316"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="105"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="448" mass="50678" checksum="994312D2F35EC42D" modified="2025-10-08" version="1">MTSTLRQRAVTPPAGQAEKDQLLREAEEKEISQGQQFVVPNFTIKQLLDAIPAHCYKRSALRSSLYVVQDAVVIAALVYGAFHIDSFLGRFSLSPVAYYAAKFALWSAYWVTTGLFGTGIWVIAHEAGHQAYSSSKTINNAVGWVLHSALLVPYHSWRISHGRHHAATGHLTRDEVFVPRTRKQLGYPEVEEEGEILGMNVSKERQSQLREALEDSPIVVCYNLFLQQLFGWPMYLIRNASGQLHYPNMTNHFSPRSFIFKASQYWQIVWSDIGVVLVFAALAFWASQRGIKEVATIYGIPYLWVNHWLVFITFLQHTDPILPHYSANKWTFPRGALATIDRDFLGPVGAYVFHGITETHVAHHISSKIPHYNAWEATEALKKFLGPAYHKSDENMFVSCYKSYRDCLFVEDGQDIVFYKNASGLAQRVPVEESGNISDSGIDMAESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C591</accession>
    <name>A0ABR3C591_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_100590</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasmic vesicle</location>
            <location evidence="11">COPI-coated vesicle membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the COPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617060.1">
        <property type="nucleotide sequence ID" value="XM_066755159.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987448"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="12">
        <location>
            <begin position="13"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="13">
        <location>
            <begin position="653"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="14">
        <location>
            <begin position="804"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0255783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="922" mass="101512" checksum="7E6F450AE218FE37" modified="2025-10-08" version="1">MSFKKDDEAGGISRVFNESPISPRKCRALLTRIVYLLYTGETFSTQEATTLFFGVTKLFQHKDSALRQMVYLVVKELSTIAEDVIMVTSSIMKDMQPNLEVVYRPNAIRALARIIDAQSVQSVERFFKSALVDRSPSISSASLISSYHLFPLSPTIIKRWSNEAQEAVNAKSVSSYSGASAYFSGGSAGGYQAVASSSYIMQYHALGLLYLIREKDRMAITKMVQQLGASGKGSSIVRNPMAICMLIRFARKIMDEDPNLRKQMHEYLETLLRHKSEMVNIEAARAICETRDVQPGDLYKTIAVLQLFLSSPKPVIKFAAVKTLSKLAQTLPQSVAALNVEMENLITDSNRSIATYAITTLLKTGNEASVDRLMKQISSFMTDITDEFKIIVVDAIRSLCLKFPAKQAVMLSFLSGVLRDEGGYEFKHAVVEAIFDMIKYIQDSRDAGESTLWELLADKIALAHLCEFIEDCEFTKLSVRILHLLGIEGPKTRNPTKFIRYIYNRVVLENAVVRAAAVSSLAKFGVCVDDPSVMKSVNVLMRRCLDDIDDEVRDRAAMYIRVLEEKSLADVLVKDEAQFSLATLEDQLTSYVHDNSKHASAFDISAVPKVSREQAHAEVAQTRSSALDVAGPSTVTPIAPASPIPSVKEAQSSYATQLSTIPEFEPYGPVLKSSTKPIELTESETEYVVTAVKHVFRKHVVFQFNVANTIPDTVLEQVAVIMQPSPDCGLIEDFIIPINSLTTQVGQAPVYVSFTRENPQEYAAGSFGCTLKFVSKEVDPSNGQPEEEGYDDEYQVEELDLGAADYITPTFVTFVNEWDKLASSPSLTETFALSSSESLKEACQSLVEVLGMLPLGGTDMPTSNSVHTLNLAGLAVPIGDGEKSSKVLARCRMTYAPGTGVTIELSVRAEVEEAARLIMAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5H5</accession>
    <name>A0ABR3C5H5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617146.1">
        <property type="nucleotide sequence ID" value="XM_066755245.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987537"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="4">
        <location>
            <begin position="125"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="311" mass="33617" checksum="49DEF5759635F8E9" modified="2025-10-08" version="1">MAGGIQNITSTAEFDAIVRSLPPSRLLVADFYAQWCGPCHAIAPVLEQLADAYKHVTFVKIDVDQQRELASRFRITAMPTFKLLKGGKEVDQLRGASPPQLSQLISRHTGTAPPPTAAASSGSKSQAATGEITESLLKQVISKGLHCLNEAKEHPLSSILGPEKGPRGNSYLESDVDPELLISIPFQDPVKLKAISIFSVISPSQAPKTVKLFINQPNIGFDDAENEAPAQELILTPEQVKGDKIQLRFVRFQNVRSLHILVKDNQENEETTRIDSIDVYGAQGEKLDPSVTSQSSAGGGSMLEKLLASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5I9</accession>
    <name>A0ABR3C5I9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617152.1">
        <property type="nucleotide sequence ID" value="XM_066755251.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987543"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="535" mass="58632" checksum="E32A7D7723E8D16D" modified="2025-10-08" version="1">MESRNLDHRRNNFKGKTQFSAQELRRRREEQQVEIRRQKREENLAKRRNLQSVITDEGIESDDEVSMDSTALGDVLPGMLQAVYSEDANAQLDATMKFRKLLSKEKNPPIDKVIQCGVVPRFVEFLSSTNSMLQFEAAWALTNIASGTSEHTQVVIGAGAVPHFIALLSSSVLDVREQAVWALGNIAGDSPKCRDYVLGEGALQPLLGLLNENHKLSMIRNATWTLSNFCRGKNPQPEWELISPALTVLTKLIYSLDDEVLIDACWAISYLSDGSNDKIQAVIESGVCRRLVDLLMHPSTAVQTPALRSVGNIVTGDDLQTQVVISSGALPALLSLLSSPKEGIRKEACWTISNITAGSPMQIQAIIDANIVPPLINILANADFKTKKEACWAISNATSGGLQEPNQIRYLVSQGCIKPMCDLLTSMDNKIIQVALDGLENILKVGEVDKDAAGPGGVNKYAQYIEEAGGMVAIHNLQHHENLEIYKKCFYIMDKFFPDDEEEEADAAAPAVDASGQYAFQSDVAAPQGGFNFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5U8</accession>
    <name>A0ABR3C5U8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617263.1">
        <property type="nucleotide sequence ID" value="XM_066755362.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987655"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="614"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="839" mass="92681" checksum="8D00196BB0C9D6D8" modified="2025-10-08" version="1">MVICSTRIALNRPLITYPTRSFVDKMALNTQPSIGLETLDGCPTRPGFGTSVQCRRLPLRHRNRPRRENQGGQKPRPLLQKIWDQMVQEATGSLKTALESAAFDHQKSFYTPHVLDLKDGKLEIIVGLKEDGIASTDDRRRFKAVIQAVDNSQIDLDTIISYSKGDKQTEQTRDVMLRAVQSVNVLLRQDAAKRFSMHGAAGRKFFTMEDGVPISGGAVVYKGFKQSFRWTSSGNPAVQLDNATSAFIEPGMLIDVAPKVLGLAGAGGDGRGGRGRCGPRGGFHGGAPGPLSDLLRGAKFTVTHWKTERIFAIARLTSQPAEGIKFTLNGKDGRPDRTYGKNFVPMEFVRLEPFNAIPMMKITPDQTAEIIREAAKPPNLRQGSIQGWRQKLNYEDLPKLKAWHLQVQNQMMSVPARVLPPPAINYAGNQSLRANFGGWNLKGVKFNKPGKPLTSWAVVSFDERCTVPDLQKFINYFTGVLAQYGCPVQNRRPALLQLNPNAGGPNMGVKPALQQAAKAAFMETKANPQIILCILPRKEASIYQAIKVTEALTSIAVTSSTMSIRLLWFAVPMSRILFLVDESFTLLSLLLLLPSMARTITLLVMSLSRGGRVEIIQLLDEMITHHIKTFEKNTGAKPQKILFYRDGVSEGQYRFCVDQELQSIKKACKALGGKYNPKITFVICAKRHAMRFFAASDADRDRTGNLPPGTVVDKGVTSPHNFDFYLQAHAGLQGTAKPTHYVVMADEAGYTADALQNLTNTLCYSFARATRSVSLVPMAYYADIIAEQARLISYNEDLETATTAPSSGSGALETVAFDPHRHFKRQFVGSDFGFTGWFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C606</accession>
    <name>A0ABR3C606_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616493.1">
        <property type="nucleotide sequence ID" value="XM_066754592.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986870"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF15">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="504" mass="55792" checksum="97D4A2FE39D6DB6C" modified="2025-10-08" version="1">MTTIDSKIAIIGAGVFGLSTSLHLKKNGYKNVTIYDYQPYDVNAYDPSKGCDGASADVNKIYRCSYGDETEYQDLAFSGRPIWLEWNKKITETPAEQLPPGLTPGDQPFIPCGFLRISNGEQLSEYDQMCLDELEKAGLRHHQHVIKDTADMDRLAEKEAADPSTNYSIKAASLKNLEGGRLTGFFDTSAGFTIADKACAWARYLAEKEGVKFVLGPETGKLDELLVQGEGEDKKVVGLKTVDGVKHGTDVVIVACGGWTPSVVPEVEGLLETTAGSVCTIQLPKERHDLWEKFSPERFPVWAYGLTGHYSPEYGGFYGFPRTKDGKIKIGYRGRKWTNYQKHPKTGRELSVPKTKYTTDKAESLPKKAIDNIKKVVGEIFPELRQIGITDTRMCWYTDSIDNSFVIDYVPGYSDSLFVASGGSGHGFKFLPVLGVHVVNALEKKPDQFTPLWHWRSVAPGEHANGLEEGKGSGRNLASLDIADKVDWKWEDGVGEIAEKIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIL7</accession>
    <name>A0ABR3BIL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_106327</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611032.1">
        <property type="nucleotide sequence ID" value="XM_066760760.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993182"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="15"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="319"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0240533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="358" mass="40465" checksum="29F755BB278EE9E7" modified="2025-10-08" version="1">MDLANQENSRRANRWDKGIKIGEGTFANVYKGTEKATGRKVAIKKIKVGEMKHGLDMTALREVKFLQELKHPNIISLLDVFSVKQNINLVLEFLDTDLEAVIRDKALIFQNADIKSWMAMSLRGLEYIHRNGVLHRDLKPNNLLIAANGELKIADFGLAREFGDAGNKMTCQVITRWYRPPELLFGSRYYSPTVDVWSMGTIFVELILRVPFLSGETDIDQLKKTFHAMGTPTEQDWPGHTKLPDYHEVGSFPKNPWWNMISSIGREGQDLARELLRFDPAQRPSAKKALLHSFFTSYPPPTPPIALPKPLAELRPRELAPDEVQGKPLLTSGAGQGLKRKAESPRTSHTVSRKLIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ92</accession>
    <name>A0ABR3BJ92_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611159.1">
        <property type="nucleotide sequence ID" value="XM_066760887.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993314"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF13">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="622"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="680"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="723"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="748"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="774"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="807"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="5">
        <location>
            <begin position="33"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="928"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="953" mass="104488" checksum="1F39C87605BC3C3C" modified="2025-10-08" version="1">MSGTANSSHPDRHTSVFVVTLVFAVIATVFFGLRMLSKVWIVKRFTTDDWFTVAAWLFTLGVTVSIMIGAENGLGKVDLDIPPDMVNPQESAIYSFTIFYNLSIMTTKTAILILYVRMAAAHAFLRRASIATMVVVNVAGAMLVLLNVFRCRPVRAAFANDDGSCINLISIFLSTSPINILTDLAILLLPLPILTRLRMEFRQKVVLVATFTAGGFVTIVDVVRVVYLQNALKAGYVNNLDNPSNTVSQQNTKNYNFHISYSLMWSGIEVSVGLMCCCVLVLKPLVMRVIPAILKDPNRSTITGTLPSFDFSQHHGSQSQSSRSAREFPEAIGTTAGIDGVGPMVISGAAESGARNALRHQQNGEIERNDEDETFDLFDMLASDPQPSGTGAHPTHPPPRKPERQSHSTTSKIKNIFGHRHSASTDTTQEPTQVFFDFVRMGGKKPLTELTAKESRKPVIFGSILFFLWGFAYGLIGTLNARVQEIHGFSSSQTFALSCAYWIAYFVAPALVAYWVITRQGFKATFITGLAFSSVGAMAFWPSAVLGSYAGFFISNFLVALGLSTIEVAANPFIALAGPGQHSEARLNFSQSIQAIGGLISPIIASKILFDELKADESRLFKVQWCYLAVAMFVLFTAVLFFYVPLSEAADEDLEKCKEERISRAEMPSNPRYCGMPMRIWAFGLGIVMMWFYIGAQETLNYYWSTLSVIIRPSFDDLWGETLARAVFVVGRFSAAVLCYIGIPPRYVLAGFTVGAFITTITTIVLPISKGTYASLILIEFFESPIFPTIFAIAIRNQGRHTKLTSTMLMMAANGGAVWPAVAYVINRRHGGHSRLLLVPAAVLFGLNSTYPVLLSSAKTYRRWVDPRWSKGKPLLEKGVREEDAGYGAGYPDGDIGDLGLSPRQRTEELRLGSEGAFLSAPLTVGLGLNLPEQEEQHPSGPEDSNEKETVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJR5</accession>
    <name>A0ABR3BJR5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611411.1">
        <property type="nucleotide sequence ID" value="XM_066760650.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993058"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="78" mass="9010" checksum="43CD43326E528F68" modified="2025-10-08" version="1">MDGRPGEKSVRTISPPKNPWSGKDHILHHHHHFVDFVIHFEKALLYTHYRGGRIVAIVGILGDLVWRERSYSESTARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJU2</accession>
    <name>A0ABR3BJU2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611449.1">
        <property type="nucleotide sequence ID" value="XM_066760688.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993110"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0242067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22140" checksum="CC24698FACD58888" modified="2025-10-08" version="1">MAMQSIKCVVVGDGAVGKTCLLISYTTNSFPGEYVPTVFDNYSASVLVDGRPVSLGLWDTAGQEDYDRLRPLSYPQTDVFLVCFSIVSPPSFENVKTWIPEIRHHAPTTPILLIGTKLDLRDDAVTISRLKERRFQPISFEMGVRCAREIGAVRYLEASSRTQKGLKNVFDEAIRAVLSPSARDAREKKKKKQQCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJX9</accession>
    <name>A0ABR3BJX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CDP-diacylglycerol-inositol 3-phosphatidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105727</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611481.1">
        <property type="nucleotide sequence ID" value="XM_066760177.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992582"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0242099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37168" checksum="B6F48D78410B0E34" modified="2025-10-08" version="1">MAPTTRSKQSTPVLEAEESTSKSTATSLGPAEGELKQRMREGSRSRTRDEVWDPKYAVDLATTTVDENVFLFVPNLIGYTRVITAAASLFFMPYHPKACTLLYSVSCMLDVVDGQAARALGQTSRFGAVLDMVTDRCTTACLLCFLSSVYPAYSMLFMFLITLDFSSHYIHMYSSLTTGSTSHKTVTSDVSRILWYYYNDSRTLFVFCFANELFFVCLYLNHYWTTPLMTNFPIPTALLTSDLTAAHPKLVGGVINVLKNLNWPQVVAAMTFPICAGKQIINVVQFWKASKILVGVDLAERRAAREQKLATQLRAHDNYLTGTRPIIHLLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK93</accession>
    <name>A0ABR3BK93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610695.1">
        <property type="nucleotide sequence ID" value="XM_066761155.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993588"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="148" mass="15927" checksum="EAA64E5A40569B67" modified="2025-10-08" version="1">MDLPYVYATDGTVKEPDLLTEASEGLLGAGMDILRGDTGGIMTSLFGAAKSAWAANKAGEKTKKTKTSPADVVMWSGCKDNQTSADVQEDGEATGAMSYAFISALNKRPNQSYQELLIAIRDEMKGKYTQKPQLSACHPIDTRLQFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKA2</accession>
    <name>A0ABR3BKA2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="9">FBP aldolase</shortName>
            <ecNumber evidence="4 9">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_106751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4 9"/>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610710.1">
        <property type="nucleotide sequence ID" value="XM_066761170.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993604"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0240202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="359" mass="39520" checksum="0AD70655C4E5523A" modified="2025-10-08" version="1">MSGALSVVPAGVITGDNVRKLFKYAKDNKFAIPAINVTSSSVVNACLEAARDINSPIILQVSQGGAAFFAGKGLKNDNQEASIAGAVAAAHFIRSVAPHYGVPVVLHSDHCAKKLLPWFDGMLEADEAYFKEHGEPLFSSHMLDLSEESKEDNIKDCVFYFKRMAKINLWLEMEIGITGGEEDGVDNTSVDNNSLYTQPEDIWDVYSALNAISPNFSIAAGFGNVHGVYKPGNVKLRPELLGKHQKYTYEKIGGDEQKPLYLVFHGGSGSTKDEIREAVVNGVVKMNVDTDTQWAYLSGVRDFVLKKKDYLMTQVGNPEGADKPNKKQYDPRVWVREGEKTLVERVKEACVDLGNKNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKJ9</accession>
    <name>A0ABR3BKJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bud22 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611691.1">
        <property type="nucleotide sequence ID" value="XM_066760387.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992793"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="90"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0242309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="531" mass="57167" checksum="D3ACC266A5F0E27D" modified="2025-10-08" version="1">MSALDNSTAPPLQSKKRKRTGKEREERKKAAIQAKQEAEATAEANGGSEEGTIVRESVQETAAPHEAASIEHQAGQSSVDVEKVAKRIPQALKSLHPVFKQAKTFETRRLIKKIKFLRSKGVTDETADLESQLKIIHEIQLHPLAQSHLLVKLRKHPLFRQAPLPSEVTSLLSPPSATSASSASTSATPALIKKAENRLCSAKIVAERVKNVLSWTVCEEGAKLVTEKKAATASAGKGGSKKAAESNDEEHDEEEEEGEEADFGGDIARPMVNGSDSEEDSDDEPVIQDRAADAAGWESGSVSGSDIESEDVGIVSESESESDDSDAIDIPSVKRAKATVPPPPSKSKPVKHEKADKPPKSAKDLTSSIFLPSLSVGFTRGDDGDSDPDLDDDPNGVAGKQPLVRKNRRGQRARQAIWEKKYGKNAKHVVKAQEEEKRQAQKAREKAEAKGRTRDSGWGARSGKAVGPAVNAASAPTAAAASHTQKVYPASKQSQTEQKKSLHPSWEAAKLRKQKMGAVQTEVKAQKIVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKP8</accession>
    <name>A0ABR3BKP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_105996</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611749.1">
        <property type="nucleotide sequence ID" value="XM_066760445.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992851"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="12">
        <location>
            <begin position="66"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="11">
        <location>
            <begin position="221"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0242367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="392" mass="42082" checksum="0135CEC8237CC14A" modified="2025-10-08" version="1">MPIATTSIPASKYRSHYDPAKVLQHPEFQSLAQDAPELSDPTLNIACAYNPAHEIHMIKKPRFAPGPGEVTIHVRATGICGSDVHFWKQGHIGPTMVVTDECGAGHESAGEIVAVGEGVTQWQIGDRVAIEAGVPCGLASCDPCRTGRYNACPVDVFFSTPPYHGTLTRYHNHPAAWCHRLADNMSYEEGSLCEPLAVALAGLDRAGVKLGDPIVICGAGPIGLVTLLAAHAAGCTPIVITDLFASRLEFAKKLVPTVKTVQIEKAAKPEEVAKQIKYAAGMELSLALDCTGMESSIRSAIFSVKFGGKVFVIGVGPSEQSYPFGYCSAREIDLQFQYRYNNQYPKAIRLVAGGLVNLKPLVTHRFTLKEAVKAFHVAADPSQGAIKVQIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLV5</accession>
    <name>A0ABR3BLV5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610923.1">
        <property type="nucleotide sequence ID" value="XM_066761098.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993531"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40726" checksum="CE5314E1161DA606" modified="2025-10-08" version="1">MARASQTMPSRSRLTLLSLRPLLPRILAHLQHLHPAKCLSLSQSLYEDLVPVVYQRVILDEKNVRSFFYGFLESPPGWGQARRGVGTKRKRLSSFPHLPAPEWPLPPITSPTQFSRGRKSAALRYTTHLTLLDPTALSILCAAHVKILDLSPVLHTASSAYRQPTTNTSVPTNPWPLGNVHTLEIGWDLMYYLADSHSPYPLFDPVPICCIPLNIRHLIIHLGDARSRSLTNGTGEGRGGGDGEGWKGGVKRFLKQAIYELAGEWELDTLELVAPRPEAGGVYIPVFDREDEQGEKHPPPARKVVINLSPLSQPGAPYEQSQRVRAYLKEAGDDGLRVEFKLNNARRVVGDLDIDMDVKGYTFVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM83</accession>
    <name>A0ABR3BM83_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cysteine-S-conjugate beta-lyase</fullName>
            <ecNumber evidence="5">2.7.1.36</ecNumber>
            <ecNumber evidence="6">4.4.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">I308_105173</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IND107</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="18">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="5"/>
    <dbReference type="EC" id="4.4.1.13" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612277.1">
        <property type="nucleotide sequence ID" value="XM_066759630.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992029"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="20">
        <location>
            <begin position="604"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="21">
        <location>
            <begin position="772"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAL0243910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="917" mass="97996" checksum="436D697B89D43EE0" modified="2025-10-08" version="1">MTTPSTPGESSLATSIYSLAPTPIDVHKERVANWRFSTICANVDGKDQYGASSTPIYQTATFKGMDGQYDYTRSGNPTRAALENHLARLYGATQTFALSTGMTCLDTILRLVRPGETVLAGDDLYGGTNRLLTYLGTHGGVDVRHVDTTDVDKVIPHLRPGNKVKMVLLESPTNPLLKIADLQEIADAVHSAAPSALIVVDNTMMSPYLQRPLEIGADIVYDSATKYLSGHHDLMAGIIAASRPAICKDIAFIINSVGSGLAPFDSFLLLRGVKTMSLRMDRQMASAQLVALYLDSFGFLVHYPGLKNHPKRDIHYKQASGAGAVLSFVTGDKALSERIVGGTRLWGISVSFGAVNSLISMPCLMSHASISAAVRAERGLPENLIRLCVGIEDPRDLIDDLEHSLLQAGAIVPNLQYTPLSETKAAELYARDGEGWILERAKGFKRPSTESTAVDKLVRGVKQGLGLSTPPKDYKTINEDIAVSAPGKIILFGEHAVVHGITAIASSVDLRCFSVLSPRRDRKVGLEVPNIGVELEWEINKLPWNLLPMHSNGERHVADKELDTALLEAVEGAVNAHVEVGKTGVGACVAFLYLYMMIAGEESNALSVTFTASSNLPISAGLGSSAAYSTCVAASFLLARQHLSIPSTDRLSKEDTDLVDGWAFLAEKVLHGNPSGIDNAVAVRGGAVAFTRSVGGKQGGMDGLHGFSSVRLLLTNTFVPRDTKTLVAGVSAKRLAEPQAVNHILDSIQAISDEARSLLGGGKPVERAILVKRLEALIKENHVHLVNLGVSHPSLEMIVAATAQAPFELATKLTGAGGGGCALTLIPDDFPESSLNELVQTLEGHGFQAHLTTLGGPGLGVLTTPSKLDQTSEQLRDAVRTHNEGEGMVVPKRASLREADKEGLHSWAERLGKWVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM93</accession>
    <name>A0ABR3BM93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611073.1">
        <property type="nucleotide sequence ID" value="XM_066760801.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993226"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT VIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0240574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="72" mass="8068" checksum="DEC239558E084E86" modified="2025-10-08" version="1">MSLLSQSTLRAARTLKTPQQVRSVHFENVVDHTLPTDVKNKYFLAAKIITFGVLGFGTPFYAAYWHINKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM98</accession>
    <name>A0ABR3BM98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exocyst complex component Sec3 PIP2-binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612287.1">
        <property type="nucleotide sequence ID" value="XM_066759640.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992039"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="48"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1170" mass="129771" checksum="1A485FE9615F8932" modified="2025-10-08" version="1">MSSVPRISPQDDVRAHITASLCAQRAPDGTPEETLITFLKVYEEDPAGGTKSRYLILAVQRTGRVFIHKAKRNSNLSFSKGKTWYLEDVRVLEVMGPSDFALTMTTRRYHWTTERPKDQAAFLTSVVKVYKEYTHGRLPELMNFAPPSSQPQPPFQQQVPPDTDLNEPPSAFPLPRVGNTDLTPPQPFGRSYRANSSSSVNSSQTLGSHYQPSHSESSRGRPSQDDDHRARRPSTGDGRAAMPPRAVGPGNGVGIGPPPAQRKMSDDRAERIGPSALRNVSAASEYEPGAAGDASLRMKKSESDMGAIAETETERSVSAGDGGKANQSNRIPSAPAIREPSPPQQSTSTPQASEQVKPKPAPPTITTTDLSVPSPGLTTSATFSSSPVSATRPSRRASFHPPPLDTTISRDVLLQSRTGLLPGAAGMTIDASEGDDGVLKNVEEMLEGFDWGMIAGGLGVSGEGRKKGADAIENRLLDELTALDSAIIHAFLESDDRTAQVLAHIDEALMELDDIDLQITGYRMQLNAVSDDISYIESQGKGLQVQTSNQQVLLNELRQLLQIVEVPADDLHTLIKEPPSSEQGAKALERAAASLYKALQAGMDTANAEVAATIARMQEYREQSSKFCKRMSDYLDITFQYQADSTLADFRKNFKKTVALESHQKMCEKLMIYTGLVLYIKEMDDARYQKLCSDYMSRVSQLHQSEMRELLTYLASLNVSSGDAGADAAFSSAPGANYAKPSALQKSKTAIGFGLGNQPKQEKRTDNNTSRAAELYRQAFTQIIRQIVVEENFINAFLRPVDTESTFADYMELDSYFRRQAARHASRARSAGMIQLLRSMMDLIFGFVEVELKNWVEATVEKVPVAIVGIIAVTERLAKEAEEENTSIFFAQLFDKQLLKQRLIMDMFVNKQIKSIEAAKTIIRRRKGIAFFVKHFPIFVERVEQQMDGNGDLPIRIKVNEAYERVMTSVFGSLEQLAKMERAETQANEDKGQLNYHVIMIENLHYFIEDVSQIKSTAMAGFLQRAKSLYEENMSMYIRLMLRRTFARFIDFFDGVDRLLQSTPANEVSLHHSYSRSALKKVLKDHGAKDMRKAVETMSRRVDKHFADDEEPSTSTANMALIGMVWKELTQEFAKETLRAQRIVAKSYVDSGLGLEFSAADVEATCKKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMA8</accession>
    <name>A0ABR3BMA8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611088.1">
        <property type="nucleotide sequence ID" value="XM_066760816.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993242"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="123" mass="13427" checksum="88646B5123AE85A6" modified="2025-10-08" version="1">MAFALQPLLSTYPGASFTPNGNFNGPHLSVQSGGPSVGYWGYVPWETPQMPEWDLPTAVKAVQEGRGTGVYGVTLEGGGQGKMFPYGWPRYGPMPLRPQLGGFVGKINPYGRSWPYGFYKTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN28</accession>
    <name>A0ABR3BN28_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612376.1">
        <property type="nucleotide sequence ID" value="XM_066759729.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992128"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0244009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="478" mass="52322" checksum="834015689763DF3F" modified="2025-10-08" version="1">MTTLAAHHALSASLDESTPFLVHTGSTDPPLDSPLSERIVTPLQSQSSSPVIRSSTYQCNCSRGRGHDDPARFFDPFVVADNDEDQEGKGLETKQAPSSPPPTSFQCIATDVQKATCSLTPPNTVVGSPDPSLTAAITNVNSTQSSRSTSPSQPAQRLTGTLSSLPLPFCANKPSHRPHLHISSNSEKVFSRSSLLTSPITFSRPALPFGVSAYYLAKPELAKRRRFGDSKQDVALSAVLLNRESKTYTAPIKFKIEAQLDGSLLERDLKDVPSKRRNVSLSAYEYEQSAKNQGIPGNGTTMRRNKAFVGKKRVQFTIDSFSELNASSVTNSQPSNLSTSSSQCTLSDYNDDPQYALERQPAHQPQVRQAKDESEDHMSIVSDMSVTAFLTVLHQIEVDMVKQLGQGLIPSWLVGWMRWVKNVSQSQSQSQTQAQSQSQSRCYDKVNFEEEEEEAFSMGCFSSFEDGCLSPGLELQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN61</accession>
    <name>A0ABR3BN61_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612593.1">
        <property type="nucleotide sequence ID" value="XM_066759106.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991497"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0245509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="199" mass="22473" checksum="6E2782ABCC16B035" modified="2025-10-08" version="1">MASINSKILRSANAPQTAPSEIEQQIAQALIDLEANVPELKAELRQLAFSSAKEVDVKGGKKAVVIFVPVPMVKAFHKVQQRLTRELEKKLSDKFIVFLSQRRVLPKQSRSTVSAQKQKRPRSRTLTAVHEKILEELVFPSEIVGKRTRVAQDGSKLIRVYLDSKDQNNLEYKLDTFSSVYRNLAGKDVVFEFPVVAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BND2</accession>
    <name>A0ABR3BND2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611493.1">
        <property type="nucleotide sequence ID" value="XM_066760189.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992594"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="636"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="794"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0242111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="942" mass="102881" checksum="F6441E7B1D797DA9" modified="2025-10-08" version="1">MATVETLLASTKQRVTAILHHDSAVTLYTLPSLDRAPPLPGPLPRTVHALAATTYSRGSPRDLLVLGGRKKVVLYGASPGAFSDVWELPLPHSPRHIVVPPPSSALPESIHLQFSPTASAILHLHPASPSARLSVADLTADPVPAVAPSSPSPPDAEEQSGYGKGALSGLGGYVGLGGKQPTPVGTRTVGGEVLLAREDTGVFYSSEGNYTRQRSIQWPCAPDGIVFSNPYIYSILPSAHSSPTVQIHLASTLSLRQTVALPLPPAGSWTGTCFSLISSPSSAPAPTPKLLIATYPTDKSLQPQGSTIHLLSSPPLSSEIQHFLLDGRIDDAIGLVEATQLTPVRHLKVLKAVQLFASGAYQPAMELFVRHNVNPALVLSLFPKSISGALGVAREAWMELFGAPSGARLGLEQGHESHESQGEEEVHDKDGEQSIHSVINSPDNQNTDDEAPGAALEALLYFLSDRRQKLSGAISSLPAHLPPESTFPALHALPPAALHALPSIPFTEMNPEELVRMAQVVYTALMRVYLKARPVLVGSLCRIENWCDVKEVEGLLKQQNKFGDLIDLYQGKKMHRKALTMLHELAKDETDKLDRYPPTISYLHKLGVPDLDLILEFSKWILEEDPRMGLTVFTGDEPEILSLPRDKITAFLSSIDRGACEGYLEYIIWTCGEEAGEFHDKLAELYMVDSRVHREKKGEQEKEKEEGNAYSKLLKFLNDSTHYRPYRVMNKLSGQEMPEARAILLGRMGKHEEALKIYVYRLQDYAAAESYCVKAYESNNNVFLLLLQLYLRPPPPSPPSPSKSKSQSKSGSGSGSTHLPPALSLISKHSSSLPASSVLDLLPPLVSISDVHPFFINTLREEHRRKLEGRVVRQLGKGRKEEVEGMLMGLEVKRVRVTDQRICPQCHKRLGMSAIAVHAPRGEVTHLHCKDKFSAKLAASRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNE2</accession>
    <name>A0ABR3BNE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612496.1">
        <property type="nucleotide sequence ID" value="XM_066759009.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991392"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12226">
        <property type="entry name" value="RRM_NOL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034138">
        <property type="entry name" value="NOP8_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48031:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48031">
        <property type="entry name" value="SRA STEM-LOOP-INTERACTING RNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="740"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="829"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="581"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="740"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="831"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0245412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="851" mass="93562" checksum="A3583CA637A3CE2B" modified="2025-10-08" version="1">MTGAETITKRLHIGGLKPEITTVHLKDRFSIFGTVKDVEELQPDALGNPRPFAFLTLETTPAQLKRCLNIMSGSHWRGALLRIAEAKPRFDLAINAINNPDPALKFKQLEKKRKRVMSARGEDVGKEAQDMILVDAKRAEKKKFWVAVNIENGDAKAARLVRPLCMRAERPIGVVERKESSRRRARFPPARSFRKVINPIQWGSQMVLFSTEEQVASPDQQEGEWGYEGFDKDEEEETAQDGKVPIGVWRKTVNGEVVQEEVVRSKRRHVGGDDYEIELDLDFGSDGMPAAGSAASSPLFGTRHLSANRESSPLFPEHRNHSDFPAPTSSQERDDEPQRRSSPILINHPAEDLEQGESLDSSLPSTSAPGSLPRASSPLFPISTAPKEGQHLTSASPAPSSPSPATLIPIPDSAPKRLSTPPIPTVPAPLIQQVRIEKSTALNVLGSLFDGPDKPASPQMERLTRNEWKGFLEDESDAEDVEIGRGKEKEKEKAPVEVEVIEEDDFKVQEPMIGISMVKESERAQNEAEISPSDEGNSSNSDDSSSNDDKMDVDPRGDGDEKQSSEKARSSSESESSDSSGDNEGDSDNSDDNSDDSDGSDDSDSDNSDSDDSDSDSDSDSDSDDSEESPSAASSAKPQVPAPSTLKDLFAPSAPSTSLFSGPSTSTAQLTTGFSLLANLAEDLELDDELDIPLPVPSAITTRKEEDELQPLSMMEGGRGKVKLNLENAADTPLFFAIPMDKESAERTKGKKGESRNPFNELHFGVPKPPAEEMEEHGYDQNGYGQNSYGQELDREEQEFPLMGFHRQPREGEAAMKGLWEKERGELTQAWKRRHREAKKQRRRKGGEDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNP7</accession>
    <name>A0ABR3BNP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104828</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612777.1">
        <property type="nucleotide sequence ID" value="XM_066759290.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991684"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04198">
        <property type="entry name" value="eIF-2B_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="12">
        <location>
            <begin position="440"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="295"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0245693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="542" mass="59473" checksum="BFF1D0BCEA21D721" modified="2025-10-08" version="1">MFDPRAGAPKRWASQSQDFQAVILVGYGQNLYPFNQGTNVISKALLPVGNVPIINYVIDWVLAAGLLDILIIVPNTFHDQIADHIAEAYNKSTHSRVRINLRKNSEGERDEDEGDSEEKDGTARILKRFRNFIKSDFVLLPCDISPPSYLPLKTILDKHRSSPKAVMTSVFYEPIESVKDAEEKLLVGLDKTSDELLLITPLEGMEEDLELRMSLLNRHPTLSLTTRILDAHVYVFRRTFLDLLATRRAKDLSSMKEQVVPWLVKGGWQRGLGEKWEPILDPPNRDPLSEALALSTTAPPSRSLLHPSSPSSEHTPLPQTTPASPSGDADTMYSSGILPTAPPRTRKGFKPEWKCQVLVITPPPAPPTPAPVHGKGGKQDKSRAPAYEPEHLIRANSLAGYWELNRRFIKSLSSATPAAKVAQPVRNIIPEDAGTAPAISPAAQISPDSVLGEGTRVGEKASIKKCIIGRHCVIGKGAKLNNCVIWDFVTVEENARIENSIICSNGRIGEKAQVKDCEFGTGFEAKPGAILKGERLIAGQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNQ0</accession>
    <name>A0ABR3BNQ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105494</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611895.1">
        <property type="nucleotide sequence ID" value="XM_066759949.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992349"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF333">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 31 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="149"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="225"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="891"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="901"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0243528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="911" mass="100839" checksum="180D5457EB668659" modified="2025-10-08" version="1">MAGGCQGARSQHSALCPATGSDLDSLSCTPSYPPGLGPSPSMPFHAVSIPAATSPSLAPVRHPLSINVPERSYSHTTSTDAYTPITPTNENGHIGITRRRHSISSPKSRAASLDYPPRPAKRNSNAWDWRMNGWTKNGEPSSYIEPDVTEEEATPVAHPIDLTPPHPPASSSLHPLPKDPNNILPLSVASSPFVSPSISRVPSPHPPPRVDSNAEQICTVSSAVHPVASSAPGSSSSPRTSVSTSSSRVWPTGRSASRSSAEDDDRGLYGSAAGPSYHFRSWFSRAAGSVSPKISAPIAPRIIRLSSGRLAGTRRWGWIFEWFGMQSGPYGPEVPKRGGLSRRSDRERERLMGQGVRRRGDKKVLGSKWLARITAFIPTEPWSISLFLIFFAVFAITLTVTIKHILNPDKEPLPWRQYCTTSYPSLYSLQYPSDQPNTKLTLSPLTPDHPIWPYKPHTSPLWTADMPQADLDAALEPVSVLIGVFTTDAGLERRHMIRQSYASHWRSRREGTEGVRIKFVMGKPRKRYEKAIQLEMEAFNDILLLDMDENMNSGKTYAFFSWAAENASVPDWEYPSHPRSDSDHVSSGARHGIEAAQGGKLHAPVWRGEKKPQYVVKADEDSFIMLGELERRLRVVPRMKTYWGYLVKNQFMAGECYALSFDLVEYIAASPVLKTLTRGKEDKLVAKWIGMHPQREEIVWSTDRCWIYDHPKAGTVYSHGFLYPSIVEQVRVENRTGLSPLVLAQRGGPGAADAYSTVSKFGTAYRPLSNDMSAVEQVEALVEGSPLSRLREYETSSSNHIVQQAFSSAESIRQKINRLYSSKPTRLERFMGDEEERGGTVVVHFIKKSEWFVETMIAMLGTAEEQSVWHRGIGTGLGALERRKGRVPVLGNEPEGFGAGDRVKLEKEDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNR4</accession>
    <name>A0ABR3BNR4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyridoxal phosphate phosphatase phospho2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612800.1">
        <property type="nucleotide sequence ID" value="XM_066759313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991707"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF12">
        <property type="entry name" value="LP01149P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0245716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28209" checksum="746BEE80C813C80B" modified="2025-10-08" version="1">MSKQLIVFDFDWSFVDQDTDRWVFEVLSTELRRLLQSRKSAGTGMQCTPDVVNDTMKDLYKKGFKKEDVLEALRILPFHPAMKRAVTTLQQRSAETTFLCLSNSNEVYISTILEKHGLTDLFSEIITNPAHWSEEAPDHLIIGRRLPASEPPHGCSVGCLANMCKGDELDRYLAANGGKDAFKKIVYIGDGGNDFCPLLRMRPGDLALVRKGLELDERVKKEGQQCGLKVDVKFWEQAWQIDEHFQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNZ2</accession>
    <name>A0ABR3BNZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612878.1">
        <property type="nucleotide sequence ID" value="XM_066759391.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991786"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="305" mass="34703" checksum="24534AFA8CEC2895" modified="2025-10-08" version="1">MSRSTISSLESQLSTATHELELATFLNKGILQTNTEYKLRIAELESENIILRKAESRLAGTEDALEDAEKRIKVLEEERDVWEEELETAKENMESAKRDKDAAIKERDHERDQRELWEERFWELRGSLEGLVERANYQTGESSRTQSHQAKSKNGLLPLLKDLTPVPKNKPKVSASTGRLSRKPRLQSPIQPLSPPIVTSSPLRRPIREVARKRKWLAESESEEEDVFVPKGGKRKVMVDPLADSNYTETSSQIASPASSRVPFNSKRRGRQSNTKQQVEITMQVKEEPISPGYENPSEDSDDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP31</accession>
    <name>A0ABR3BP31_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1/BLIP-II protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612904.1">
        <property type="nucleotide sequence ID" value="XM_066759417.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991812"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="230"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="47188" checksum="B979AA886AA550E6" modified="2025-10-08" version="1">MPPTLLSCGSNAASHLAINHPNDVSVFTPTIYHHSLPPIFPSARIIEVVSASAHSLLLLSSPNSSSSDDGQGKECRNILLGAGTNTLGQLGPRCSLWDDVRPEGQWKLLDLSQAYGLEGRWEPVKIAATWTTSFVVYQQVQETLSDGGTSENPKESLARQVIISCGSNDFGELGSSTPVMLSGTPSPIPVSQASQKPTLVDVGLKPGEKVQMIKGGQRHVIVVITGLECQRIMGWGASRKGELSAATLSSVTAAGPSNKAKGKSKANPHPLTSPPTLIDLPLQRGQSVVNIALGASHTIALLSDGSVLGWGSNLKGQITGVHELENVRAIAATWGGSYFLTSDGIYSQGSNTHSQLLRGQASSERGKVNIPEGRQVEKIVAGTEHLLVLARAGGQEEILFAGGWNEHGNLAMGDERDRDALERVELKSRVLGLWGGCASTWVWVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP36</accession>
    <name>A0ABR3BP36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS0</name>
        <name evidence="10" type="ORF">I308_104974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612921.1">
        <property type="nucleotide sequence ID" value="XM_066759434.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991830"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="9">
        <location>
            <begin position="208"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="292" mass="31499" checksum="526C310750258086" modified="2025-10-08" version="1">MTADKLPKALQATEDDIQLLLAAQCHLGTKNCDKSMENYVWKRRADGIHVINVGKTWEKLVLAARVLATIENPNDVCVISARPYGHRAVLKYGSFTGAQAIAGRFTPGSFTNYITRSFKEPRVIIVTDPRVDHQAIREAAYVNIPVIAFCDTDASTKFVDIAIPTNNKSRHSVGLMWYLLCREVLRLRGTVPRGPTGPSGWDVLPDLFFYRDPEEIEREAAEKAAAAAAQEGADAEAAATSAAAGVTAEYDAGNAADAVLAAQPTETALDWSDEPVAGDWAAEPAADAQGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP55</accession>
    <name>A0ABR3BP55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0246974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612935.1">
        <property type="nucleotide sequence ID" value="XM_066758487.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990862"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045359990" evidence="2">
        <location>
            <begin position="23"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0246974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="508" mass="53562" checksum="4C9AE7319E2C669E" modified="2025-10-08" version="1">MILSISMTKLIGAFVVLGVAQSCWYDVYLESPYDYYFRYCSSGCANLAMTDDNFSSCCLPFTSGQSTPVVCTSLSLSYAAMGTTCTWGDVSTTDAPTSTPVDSTYTPPPYIHAVTSAQASATDDCSTEESDDNPDVATETSWVTSTTTTPCSTTSAVTAPAPSDESCNCGGESGQAAESSNWEGNTLPASFTADNRRRDIMRRGSCECSAISSSLAETSAAAVATSVADTSHLAITSFEPAVTSSGDSCNCGKKSGQAAESTNWEGNTAPSGFTPDNRRRGRDVMKRGDCDCGEESSEDGARTSGIVASSYVYEGNTAPTTFAADNRRRVALKPRNIALANFNSDNRKRGYKGIVRGASVGGKPENEKRKYDMVHDKEVSSKDRRSPDHHSNVAGNAERKIPTAFSRYYDKRDTPTTTIHTSTTWVTTADCGTEAVATSAVAETDINASATASNSSTDAERNSSQAGESISATEDTESASAITGVPSTSVPWEGSGPPSSFMGDNRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPM3</accession>
    <name>A0ABR3BPM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">T-complex protein 1, zeta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612733.1">
        <property type="nucleotide sequence ID" value="XM_066759246.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991639"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0245649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="552" mass="59945" checksum="0F51FA0DF59F3E8B" modified="2025-10-08" version="1">MSSIELINPKAESVRRTQALQVNTAGAVGLANVVKSNLGPRGTIKMLVDGSGQIKMTKDGKVLLSEMQIQNPTAAMIARTAVAQDEQCGDGTTSVVLLVGELLKQADRYIQEGVHPRVIGDGFDIAKKEALNFLDSFKQTPKLDRANLISVSHTSLATKLHAKLAQKLAADVVDAVLAIQPPEVTEPGAHREPIDLHMIEVMKMQHKTDTDTQLIKGLVMDHGARHPDMPKRVENAYILTLNVSLEYEKTEVNSGFFYSSAEQREKLVESERRFVDSKLKKIVELKNAVCDVAVGSNEKPKNFVVINQKGIDPMSLDVLAKNGILALRRAKRRNMERLQFACGGIAQNSVEDLTPDVLGWAGLVYEHTLGEEKYTFVEDVKEPKSVTMLIKGPNAHTMTQIQDALRDGFRSIKNAIEDNCVVPGAGAFELACSAHLNSSLKTLAKGRAKLGVQAFAEAMLVIPKTLAANGGYDVQDAIVGLQQELEEAGEDGVVGLDLKSGEPMDPVAEGVWDNYRVKRQMLHGAATIAVNLLNVDEVLRAGRSSLKEGPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPW6</accession>
    <name>A0ABR3BPW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613191.1">
        <property type="nucleotide sequence ID" value="XM_066758743.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991121"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="612" mass="65283" checksum="8C660A6A99DB2B42" modified="2025-10-08" version="1">MPSLAESLDALAHHSEQIAYLSTLNASPPGPFTTAYLHLPPPHLSHLGKGNVLELIRDASDAERRLFKFVGENNLPGAAGGGGNKRVEKREGGVVTPLKELKRGGGDGEAEKDEVEVMLRTALKLVEDYRPMPRARAHVINLLDQHHRNLDRLAELEMLIAEASKPVDTPASPPPQSEKKEGPQQEPVKLTPEEAIKAEESALRALEAKIIPLRRVSQPSQDEQLLDPQDMVPPVGRNIPQSPPPSHPQYQFEPQPTPSQAQSAQPRTPGRSMPHVTNSLVNATPRHAIERLERAERIDRFSPLKLITPRAPGTLRGEGTIFGRRMGSSSASSSKLGAGLRTSMSDKRASDEAGETSHNPAPAIADAPSTPFEAAPDPSPAGEDPDETMRLTRVSPSTASPIKTAAAGSKLPAPPSPPKKVHLPVEGLLQSVPDIDVLAQTPQICADGELDGVDTDAEAVKTGVEKIWSNVGDIMRQGLESGVTVEKDTISSVRHLIHLSKSNLPPPPSPSTSSSLSSFSHGGLPPPKPITSETILFAHLFLSILRVSSNSDGSPGEMDMNEIKESLGNVAKEKGWDGAGGLGTKVIYAAVGKRVVKIERKGGGAGRVRFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ10</accession>
    <name>A0ABR3BQ10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613236.1">
        <property type="nucleotide sequence ID" value="XM_066758788.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991167"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="560"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="629" mass="68592" checksum="1D299B6257668A55" modified="2025-10-08" version="1">MREMSASSSSSHSSEVPGVPRVGAVRCYWALLKPRYDPNPDPSITQPQLELEFVHFDPVLDAHLSKQKGSMMVRSVLEFIHPHEREQARKDLLGAISADDLQGSVTRVRFARLSQIRTLLGCPPEENEIPADAAVIVEDDEYIILDLVLNWVATGLLLAFFHPIKDKDPIANNDPKRANEEWSNWCGTKFMGDDQIEALRRNVTYNIPIAPSTHRPPARVFQLHLLPPDNMSYAPTQLIFSWPPARPTGVPVGPDGLYDASEYCDMMKHVDMDPSQLKAGPGELRTNCTTRYGAHHLVTTEGLHRTVASVFIPYGKLIFACFQTIKAYELPRNQNNYAVQANGWRKGHTHQSVGGRMDPAATEHSINVPNPHTQAQSQLQQVLAQSHTQSGAPQPQPQHSAIDWSTDSSLLPGRQDSGNGDWDSSAAYGLANLGMAVPKPGSQTVSTMSQHQEHQTDGSHTASSGATYSTNSSSSALYSSSDYSNPLYSAIPPQTQSSTSVSSSAQMGPTQSSTTGQRPVHSQFLKGSIARAVQSGASSHSSGKSSSRPLVKPPGDVEACVMCGTRESPEWRKNTNGVKDLCNACGLRMARQVAKRDGKQKPRKKREQGNTPSRGESVTKDGYGISGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ23</accession>
    <name>A0ABR3BQ23_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613251.1">
        <property type="nucleotide sequence ID" value="XM_066758803.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991182"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="405" mass="44940" checksum="03561AAA1A3B1595" modified="2025-10-08" version="1">MDGQAPSPLMHTPIQRPYPYHPNAQFPYTQQQPYPSPLSTNPTRPLHTPHPYNPQQRPIHPLPNGHSPKFPMTPPYPPYLNGPIQTPPPSSSGSEALPSNHIHIMQTTPQAVMLRSNSTLSTTSTNRPPPLSNGPSPAVEEVIVDMSDQCDMYPAQQAQMRQVVVGPRMGMDRVQARAVVNATRPNEMDGVPRQMVVSQQIPIPNALPSTGVIPASDSGMGNLWQRPLGEGTGLRVVANFLEGLGAMQNKGLEDWLSFIISHFENNSRFQLVLTGEQFQMFDVPTTYLPRFFLSLPSSPSIILTDPIESLPSAEETMVLCPDMEWRCGAKSWKGALNMVVGRRGKIEKMDVVLGNKNDEGEMFLKGALRVLKMAQEMESFALVMRLAQQENLPPREALQQFIQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ58</accession>
    <name>A0ABR3BQ58_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104981</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612928.1">
        <property type="nucleotide sequence ID" value="XM_066759441.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991837"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="312"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="446" mass="50220" checksum="F11CA6287ECDDBD3" modified="2025-10-08" version="1">MSKFKISSALWDKIHHFASFPQTGVSLQQMILFGQNPSQGTLLKASQFLSEELPIRLSHRVVELEGLPDGLNKMPSINTVKEWYAQSFDELVSFPRPRLKPELEEILRIPPAPTQPFPSATPNPSLDPLMREGPVGSGFVSERHIGTGGNGIGVGKRLRIPIERRYFSPPPPTIIYPPEVHDYNEKFTELLQVIKHRHDPTVTTVAQGVLEWKRMQRASVIGTPIQEFLDRFYMSRIGIRFLIGQHIALNTLPPHPDYVGIICTRANIHDICQEAIDNARYVCEEHYALFKSPNIQLVCPPDLTFPYIPGHLSHICFELLKNSLRAVVERYGVDNDDEYPPIKVVVVEGREDITIKISDEGGGIPRSAIPHIWTYLYTTMSDEGLEDTIQGSDFKAPMAGFGYGLPLSRLYARFFGGDLRLISMDGYGTDVYISLNKLSSSREPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQB1</accession>
    <name>A0ABR3BQB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial K+-H+ exchange-related-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613341.1">
        <property type="nucleotide sequence ID" value="XM_066758893.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991272"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40050" checksum="B33A2C038491532A" modified="2025-10-08" version="1">MSPKLPAAKATRQFRILALPLARLPRPPPHSRTLPTTPPPSLESASPTIPPTPLILFHAVQPEPPADSPPSLITKALDKSSETWLKLGEKPRGSWMYWFYEKGEKLMDRIEYEEWALKAVKEGEGVKVSKDGQVLERIEIPLILPKLPNQEMPTLLPKLHRFLLKRIPHHKKMMYRSILFSPVTWPFAIIPIIPNFPLFYVLWRAWSHYKAWRGATYLEQLIKAGLVVEKECPELTEIYARKALHHPHDPLTIDQSGKIKVGTTEQPLPPPAPGPITSQAQHPSLLLSPSQIPLLAKTFALKANEVVDVTRAVEQADYRARKADQVEAEEKKAKEEKAREEKEKENENEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQD4</accession>
    <name>A0ABR3BQD4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612450.1">
        <property type="nucleotide sequence ID" value="XM_066759803.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992202"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0244083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="66760" checksum="715C271254483938" modified="2025-10-08" version="1">MSPVKIPDGIPNGVMKITAPDVDSYPYNVGGYSCKINTDSKDCQTWFDRGLIWSYGFHHEEAERCFRYAVSCDPHCAMAHWGIAYAGGPNYNKAWERFDEADLKRALHKCHLAVSKARELATTPLEVALIDALCARFPSEREGDYKHWNRAYSEHMDQVYEKHGDHLDVVALYADSLMALAPWQLWDLHSGAPREDSRTLRIESILEKALQRSESLSHPGILHFYIHLMELSSKPELAIPAADRLRNLCPDVGHLNHMSGHIDLLIGDYRRAIATNIDAIRGDELYMKHGSMTDFYTFYRLHDYTFPIYAGMFNGQFRIAMDTVERMEKSLTEDLLRIPSPPMIDWMEGFKSYRVHVLIRFGKWHDILQLAFPDDRQFYCVTTTILHYARALSYSVLDQVENALEERELFRESRKKIYPSRFEYPNSWQDILNVAETMLTGELEYRRGNYTYAFEQLRESIKYYDNLIYAEPWGWMQPPRHAYAALQLEQGNVEEAAKTYAEDLGFSDSLPRAVRHPNNVWALHGYHECLVKLARHDEAKILEPQLTLALAVADISIESSCFCRRVQPAANQSMCCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQH6</accession>
    <name>A0ABR3BQH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612228.1">
        <property type="nucleotide sequence ID" value="XM_066759581.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991980"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31041" checksum="E94026E87957F532" modified="2025-10-08" version="1">MITLTIVRHGESTDNLKPFWAGWSDSPLSQHGMSQAKALGESLKDTKFDYIFTSDLKRAHWTSQQILKNQADPKPPLVVSELLREQHFGEGEQKPFGDGSRWARQPGRVFKFPGGESLIDVRKRADQAVEQFIEPILRECRGRPATSKHVAVVAHGIFNSELLGALMARRKMNAPLEWSYRGMTNTGWTKAEVGYADEANIETTTRISTNPSGPISPSSAPSSPPSSTPNPDNLEPLVIKVLCSDVTDHLQGVVRQKGGLGSQSYDEKQEDIRKFFGGGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQM4</accession>
    <name>A0ABR3BQM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Allantoate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613448.1">
        <property type="nucleotide sequence ID" value="XM_066758046.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990408"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF59">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="62397" checksum="6F41FAAE0D38F463" modified="2025-10-08" version="1">MTSELKKFDSSLEDEKVLTEHIEVSHAVTRDDLERGRTKRTANTQLDDAAKLLEEAGGHVEYTHAENKRVLRLIDFYVCLPMCLVYFIQQLDKASVSYAAVFNLQVEANLVGTQYSWLSSVVYCAQLVCQPLSSYALIVFPVKYWVMFNMAAWSIVTMCTAAATNFTGLLLARMFLGIFEATILPSFILITQMWWVRREQSYRTIAYQIANSFAAIFGPLLSYAVGKACDGSDKIKAYQGIFLFMGGFSLVLVPIVWFLLPNSPTTARFLKKGNDRLIAIDRLAENNTGTKASTFKWDQFWETYKDPKTYMWAAMWFCCACPSGGIGAFGGLITKGFGFDTFTTILLQMPPGAIGIITLLVSIYVTNKIKLRWPVIATVCVFPIAGGIALTQVPSTKTGGLMASYYVAYLFAALQPLLISWCNLNSAGTTKRVLTTATMFGALTVGNIVGPQVYLKREAPHYHTGLYVDIACWCILLILVVSMGIYLKLLNKRQEARRLALGLPADLKDMSIMSMEEAEAYKTELTQVMRAQGKDLDSLNANSFDDMTDFENPMFMYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQN8</accession>
    <name>A0ABR3BQN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104254</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613180.1">
        <property type="nucleotide sequence ID" value="XM_066758732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991110"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="316"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0247219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="407" mass="44937" checksum="EE9F374B83C78C83" modified="2025-10-08" version="1">MLMLQRPTSSSPRDIPPHSVLQFSSPIDYSLSPTTSFTGLGDREAINLHLSHTSAPLFQTTPAPSAIMESSWPTQSSISYYNQGSIQTSRQPSSPTNEYSDRTPKRSVAQPQMPAFLPPPPPPGHQLPESGGSSLPSFSHSLYSPYHGPGGNLPPSNPPNMAHSMPSYSHISALSGTGSGFQYTNHSPMGLNEPLTSHSRSQITHSYHEPPRLSGYSSSPNLHQLSPVSPTAHLIPNMHAPSASPSSSSFPSSIPRTPATLPKGMKRQSLSSEQSFGSWDDEREMSTGKISGDRKHEKDPQPWGMPQEEYKKLNPKDKKQVRNRIGARRFRAKRKDYVSQLETGIQFRDDEIANLQSQLESQRNEINELRLQLKLPLLPRGELPGLGLTMEAHGQVERWENNDSMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR12</accession>
    <name>A0ABR3BR12_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613598.1">
        <property type="nucleotide sequence ID" value="XM_066758196.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990570"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="106" mass="10981" checksum="3AC38A563A5F9FCA" modified="2025-10-08" version="1">MSSQAAQQHTANQPAVTQIVDPNDPNAVPPPSIVAAGTGLSAAPREMADSSQEAATAPGSGNISDHSEKLSFKDQVNGYAKKFAGAAFRNTEEKEWGEKKLAGDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR22</accession>
    <name>A0ABR3BR22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613574.1">
        <property type="nucleotide sequence ID" value="XM_066758172.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990546"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="186" mass="20556" checksum="568F26C3A426A910" modified="2025-10-08" version="1">MTLDSSLDLLFDPSILPASVQDELGPDLYLRPLSSTDVSRGHFELLSVLTSAPPQSVSTYETIFQEMKASPGIYFTVVVVHRPSDQVVACGSVIVERKFVRNAGLVGHIEDIAVSQSMQGRKLGLKIINTLVDIGLVRGCYKIILDCSEKNIPFYEKCGFKQKEFQMVRYLLDPSDVVKVSTASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR40</accession>
    <name>A0ABR3BR40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613330.1">
        <property type="nucleotide sequence ID" value="XM_066758882.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991261"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050659">
        <property type="entry name" value="Peptidase_M24B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112:SF2">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="265"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="514" mass="56209" checksum="ADC2ECC2E93E57DF" modified="2025-10-08" version="1">MSLSCFASPASRHNQQGTYDGLLGEDDLPEKSFETSFSSIEEDPKSTRPVQTLDQRVIVAVLFLVIFMGALKYMPSSSLMDIIASLSTSDSPSLSAAVNHKCEALLTPPPKTYSNRLNSLVSELPQSTVWIAEPGPSASYFIGAFSTQDWQLSERPFLVAIGRSPRGSPRIFLVTPEFEMLRASLIKLPKDLDGSVIWVKWREDQSPYEALKTALGYGVDAFILDGLTRQFVAEGLRSMLREEKDDGVLEKIGLIRERKSLWEVELLRCANQKTLHAIRKTKKRMYLGISESQTCRILEQEMAKTGLVGGGGLVLFGENAALPHGSGTDRLLNKGKMVLIDAGGEWGGYVSDITRTFALPNSKIAPSHIELWEVVRKAQRASYAHLKTTNTTAPATFAQLDKAARGVVDSWTGITAGTDTPNFDIFTHRLGHGIGLEGHESPYLVQGSLGERQVQSGHVFSLEPGIYLPVNGKTVKGINGVGVRLEDCLIVTEDEDGSLKGEWLSGPVQSWGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR93</accession>
    <name>A0ABR3BR93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histone acetyltransferase type B subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613134.1">
        <property type="nucleotide sequence ID" value="XM_066758686.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991064"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="236"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="282"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="326"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="435" mass="48446" checksum="9204E09672155087" modified="2025-10-08" version="1">MASNEPITIDDAGDDFDAVEDNQAINEQYKVWKKNTPFLYDTVITHALTWPSLTCQWLPDITDVPDTDYTSQRMIIGTHTSGQANDHLIIAEVLLPKKGAGISDKALADLYDEEKQEIGSYTASPARIRAIQTINHAGEVNRARYMPQNPELIATKTVTGEVYVFDRTKHESKAPANGECKPDIRLQGQTKEGYGLSWSALKEGHILSASEDTTIGHWDIQGYSKQDPSLQPLRLYTGHSAYVADVEWHPKNENMFGSVSDDGQIMIWDTRSDNAAKASSQVQGHNAEINCISFAPSSEYLFLTGSSDNTIALWDLRKLSTKHHSFEAHTNDVLQLSWSPTSPVHFASASADRRVHIWDLDAIGAEQTPDDAEDGPPELLFVHGGHTSKVCDISWSPNSPWTIASTSEDNILQVWEPSRHLRTPYEAEFDEKDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRI0</accession>
    <name>A0ABR3BRI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613224.1">
        <property type="nucleotide sequence ID" value="XM_066758776.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991154"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="205"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="565"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="754" mass="81957" checksum="F913350D8D22D8EC" modified="2025-10-08" version="1">MQSSSNIVPDTEMVNADQHPEAGPPNGEASRASTPLTIMSSTEDPQPSVGSKKRKQSEESLSASARTTRSRRQTPSKMSSSTPITTFSRKKGKSPAGPLSILVPPSNGQIPESSQNAISSKATSPALDSDLALAVDADSIRREAAAGYESRLRARQPGNAKRDGGQRMGISASGRDVRIGGSTRQAAQQSKKDKGKGKSDVQPNQDFCSACRGIGRFLCCDGCPRSFHFMCLEPPLKLDELPSEEMWLCKQCRSEKAKAEGAVLVNEVEIPAVPAVFRAICKKIEEENPEQFRLPADVRKYFAGVATGANGEYVDSKETRTKIDRKGFLEDRDPFRLRDGRQRKVECYHFSCDYCPLSWHLDCLSPPPTTMPSAGKKWMCPNHPDHVMPRRRNLQENLQTIEVVGRGQSNNGNIEIANDSDGSETSEMEFEDTIINRKKFRVPEKVIRLDFWEKLKKERDVVQTPVTVQEEMSADEQDAQGTIPPMEDLNAAAMMMALAFSRHTHHTPAIPPVSEPSGITSAPIQQIGESSLGPSRAEKEKSAIDTPPSKSNSVLKAAPFLSLRPTQSWTPAGSRFHNQRAGHAPSQSQPISSTPSDSSKTSPKSPRPIQQSSILSPTSADVTKSVQESSVPAMLPIPPSRSRFEPPSTIRFALPPKPQSVSSASMSQTHFPLPTPPITSHHLAGAPGPVGSTKLPPSPWLNAPRTSWAPTESNMGSVRNEGLSQEGKPKIMLRVPAMKNEEGSFDQTGGNRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRL2</accession>
    <name>A0ABR3BRL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_104651</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612603.1">
        <property type="nucleotide sequence ID" value="XM_066759116.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991507"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="432"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="361"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="645"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="698"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="796"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="723"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="819"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0245519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="980" mass="108563" checksum="40200AF13F325380" modified="2025-10-08" version="1">MTVTGSTSAEVAASSYVPPYKVTTSYAQSPEVTGSVNPTVSSSAISGVDYATAYLEAHMMSWPSYRYAYLFWIILAGLAAIYALSHHLRLSAGSLGAGYSKWGMRRKGLGSKDGRRGTILPSNNILLSIAFLIVLSVVLCVVGYDYINPSSATLNFASYQKRGFVPYGISKAFWTLGNRFGYMAFAMTPLVVLFALKAPPFAFLSLRPLTHLYNDKLALFHRAAAWLVWSFTTVHTILWTIQLFRDKRDGRAVWFTIWNSYHFIFGCIAYGLMTAVMVLSLKPFFYIAHVVLVFLTIVCSIIHHPVLWFWMVAALILWGCERTVRLIRMIRINGIFGKDKYNAVVSGRSYDQYSYRKQDFKQNGSYSTPQRNPGNPYDDKSLPQPPSMHRSQTGDVSEFGASKSQIGYDEGSLQPLGSYDARYSNIDPTATSPPYHERVKSVANSIPPNLPIYMPTTIPIGHAQAQLLPSRTVRLTVRVARPFHWAPGQSVLLYLPELSWFQSHPFTILNNDPNEIMLLVKARKGLTRRLFNYVRKRSLAAIGINSVKDRRISLPSMRTSSGESNLYVPPIFLKAWVDGPMGSSERVRWKDHSSVVVVCGGSGVSFGAAICEHILLGCKRDMVSADQLQIDIFVTKGQRLKDDFAPPQPVFARGGTHSREASVGSVTSEMSVDSSSADRDEAVENTLKESYADVIDLTNYEDEEDVNDPAENRLSNKLEQQGKLRRARSRKIAKRKSAAKLPRTPSYPPSRFQSTYSYDNPEESYAPINLGYGHSPASSLYDPFQESRIPTVHSSIAMSPSASQSIPPFNPHHDKRQSIRSVPDSTNTGNDPFVAGSSQEHGSSSVGHSTLTDETQGAYPGDPFRDIQNALSRTSRTQSMVLLENSGADPNEDAGLWIDEADYAAMSIMSEMARAGKPKLSAVLEEEIEIALGSLIVATCGPVTLNTVVRNLVSKSISPSRIHRGDKRGHIVVYSEDYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRR3</accession>
    <name>A0ABR3BRR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613827.1">
        <property type="nucleotide sequence ID" value="XM_066758425.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990800"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="642"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="744"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="649"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="90743" checksum="859688D1F20624AF" modified="2025-10-08" version="1">MLQPENDGTRRSGLPNETGPSRSAPKRKSRSTRGLLNKVVALEDQMQHVQSNLENVVSLLLRLAPTNLPAGSQASTDLARHNIPQPGLSGSNNNVQTHLAGFCEASEQRPVSSLEQWVQQIAGDAASPTVDLQQQFVPQDRTVGGSTAEGSEMSSEDERDHTVEEETKEGLTFMRDMLRSEEKKRLHADGHWKSPIESGLSSHRDHEHIAADDRGHRTKTDDRLRNPCLKRKRSANDWGPSDRSPARVRDPIHLGLCSEAQGKELFDLFFQVAHSFIPVFDPSKDSWESLRRRSPFSIFAILFVGQKIRDAGHEPSKLQQLLREHAESIGKTTLFCPIADIEALQAMIILASWGDTGWRPGSHAVSMAIDMELYKCLPRLAERLQTPSAFTNDRDEDTERRLVVGSRLWLLVCKMAIEMAYNYGRPMLIDECLIFPHLHALLKHPAHLPTDSRIVAFCELLYLRLTLHRNIIADNRQELDNLLQIFNDEARGWEEKWRNYYIQQGVHMDNILVTDLTTQRCFGSVLANSCLLRDIRSPHDIEKLSPHRRCLLLASLDDARLICSRIIATEKDKLLHANHYSHVALASVIRIYIRLATLFPRSVDLRRVARDLSQLTEVLARFPGFYFAQQLRYAISKARQRRILPPETRPTSPKSLFNQSAEYTRQNQPKPRSSSVPSMPWFNHFPPSELQPQQHRTEKFPEQAGSTGTTMASESPMEFDPFLAEHLLNETFNQVRPLDGISEWNPQSGEGGNWNQSSQGGNEAEWLPSQSSVGTAIPDAHNSFLSWLEFPVLDFNEFGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRZ0</accession>
    <name>A0ABR3BRZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613909.1">
        <property type="nucleotide sequence ID" value="XM_066757525.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989879"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055225">
        <property type="entry name" value="DNAJC11-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22774">
        <property type="entry name" value="DNAJC11_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0249722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="622" mass="69383" checksum="31F352AA08402A42" modified="2025-10-08" version="1">MSFDPGPSSNYYRNFAASADGPLQPPSPPRSPILGATLPPQQAERDLYALLNLPKDASEATIRDRYRSLATTFHPDRQRSDRAREAAHAQFTEIQRAYEILTDPTKRAVYDMFGEEGLKTNWELGPRVKTPEEMRKWFTAHSYEKRSMEAEALVKPKSDLEVVLDARAVFLPKKIFPDPNAVKHDPISRVLRVRPGRTVLKHSFEMPLSSNTQFVIEGQALSRNGRGGANVLGTVKHQFSPKFWVETGVTLMHPRIGKVKATYTVDEDQYVTASVVQSTLTAPPQLGFTYGRRLYADTTGFMLFEPGSFSIGPWGRNRPESQLNPSSLSVGLTNAKRNGSGWTVQTTAGLANNQITADWSTPIPGGLKMKFGAELGLGQSIAGFITAEGKVTDNVKAGLILQMEIGGGIILKVKVNRLGQKISIPILLAERLDPFILLGSTLIPAAAYAGIYKLYLLPRKKRALVDRVKELRHEHKEFIRQKRQEARDAVHVMERSVEVKLAQERERNGLIILSAYYGLASSFTERGIIISEKINHEEEEEEKEGEEKIIDVTIPVQALVQDGRVYIPGGKGKHNIIGFYDPCIGEKKKLRVRYLFRGKMHEVTVDDTSPLRAPVRAHALEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS68</accession>
    <name>A0ABR3BS68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612843.1">
        <property type="nucleotide sequence ID" value="XM_066759356.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991751"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0245759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28384" checksum="6068D9D67FAC5130" modified="2025-10-08" version="1">MSTQQAAETPTSWPVNKEKLNMPSDCKSGDSSAGPTASDVDKYLNSKILSPSFGGDPIFQRISARAEQAGLPNIAVSPQQGQLLTILALSIRAERILEVGTLAGYSTACLARALPSHGQIDTLEVKPEHAKVAQENFIDADLYPFPKIHLGPAIEILRRMETPDEGPYDLVFIDADKSTTLDYFLEGMRLLRKGGLIIVDNAVRGGRIALSQEEDSNPDAAGMRKLYDWVHADDGKSILMNVTQTVGDKFWDGFAIAVKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSA9</accession>
    <name>A0ABR3BSA9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="10">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103144</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
            <location evidence="10">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="10"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614029.1">
        <property type="nucleotide sequence ID" value="XM_066757645.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990000"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="206"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="530"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1084"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0249842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1116" mass="124750" checksum="6228785215E13D87" modified="2025-10-08" version="1">MSMLPPKSPSVKRFAQNAEKRSTSPNPSLLMNLNTPSPAAAKQPKVVLGVCAMDVKARSKAMREIITRLVDIEKGGLEVKIFGDVVILEEDITHWPPVDVLISFFSTDFPLPKAIAYTQLPNRTPPISINSLSMQSLLWDRRLVLAILDHIGVPTPSRAEISRDGGPRIPRSLRRQVRRELGLVLPGPKAKDEDEWGEVIIPEKWRGKQRKDTVPKATEVILREDGDAILVGDKVIEKPFVEKPVDGENHNVFIYYKGGGGRRLFRKVGNKSSEYDPNLYHPRTIGSFIYEEFINVDNAEDIKVYTVGSKFSHAETRKSPVVDGLVRRNADGKETRFITPLSEAENQYARDVVEAFGQRVCGFDLLRCEGGSRSMVIDVNGWSFVKGNQAYYDKAAEILSGVCQLARERKVQGIQTGLASTATINAPSGGSTTSTLRATVTVLRHADRTPKMKLKFSFPAHEAWSQPFLRLLRGHREEIILRDTHQLQYILAAAEESSQTPGITQEQLLKLSQIKEALWKKMSFPGTKAQLKPSFVKKKGDKSEKKDKKKKNAEKEDEGDDTETEGRKKVNDWLRKGESAQAATTDSTLPIEPLTSVADSVDATSQPDMPRNPEPEATQDGTAHGKHAGCVNDPDIPEGLEKMQLVVKWGGESTHSSRYQSRDLGDAFKKDIMIMNKDVLNNVKIYTSSERRVINTAQIFAHALLGVEGSSSSSASSIANARNPPEQGPQISHLIQRRDLLDDNNAAKDLCTDAKKKLKMLLRTGETERRPDLAWPKSFKKEPVEVVSDVIEQLTELRAIMRRNYENGNVEKIPQQRWCSGDSPWLFKERWEKIFDDWVGVKQEKFDPSRVSELYDSIKYDSLHNRTFLFAVFDPEGKGQASKAGAPNQDRRLHDLYGRAKTLFDLVAPQEYGFDADAKEEIGVLTSLPLLRKVWEDLDEAKTTGKSLACFYFTKESHITTFVHLLLASGLPFTNVRIPELDYCSHCTIELWEKSTGSGQKDFSIRLSISEGAHSPAVLDSNVDARHSLTVQPRKKLSSHIDYELARQCFSKHFNKGLSFSTTPLEGDEVYLKKSIEDESVLPLSSLQHKAGDETPRMISSASSDRSHPGASDGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSN5</accession>
    <name>A0ABR3BSN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614152.1">
        <property type="nucleotide sequence ID" value="XM_066757768.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990124"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13425" checksum="0541CB101EAFD81D" modified="2025-10-08" version="1">MLYALGFLVLLFIIIVVWLVRLAILHANLAGRVFTGRYQSSSDSGPSPYCRGNDRGAVVRQSNGSEASLPAYGAESLPVPPETAYQPSQTRIRSDQTALNSVMIPEVPPPKYTAASEPVSTTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSP7</accession>
    <name>A0ABR3BSP7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613023.1">
        <property type="nucleotide sequence ID" value="XM_066758575.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990952"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="172" mass="18348" checksum="B12872F05190CE09" modified="2025-10-08" version="1">MSSQSATPSAPLFFSHTPRTQLLLHSALSSAELFAAFTPPVYLISTLVLRRRPFSIRRLMYNSMGGVLAGAAVGGGYAYLRGMREGELKVRERLARVAMDETQVRRNDYATISAALSALLVPAIFLNRARLPVLVLGGGSIGLGVGAAAFVVERLTKGQDTGVNMPGDEKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSQ8</accession>
    <name>A0ABR3BSQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_103296</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614180.1">
        <property type="nucleotide sequence ID" value="XM_066757796.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990152"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="13">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="14">
        <location>
            <begin position="127"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="12">
        <location>
            <begin position="232"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="15">
        <location>
            <begin position="465"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0249993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="614" mass="68052" checksum="8919D685FDA2A5CE" modified="2025-10-08" version="1">MERAKRDLPKIRDEERETMFGTVFSVSGPVVIGENMRGCAMYELVRVGHDELVGEVIRIEADRATIQVYEETSGVTVGDPVLRTGKPLSVELGPGLMTNIYDGIQRPLKAIQEKSQSIYIPRGINTESLSREIKWDFNPANLNVGDHIAGGDIFGSVYENSLVDNHRIMLPPRAMGTITRIAEKGSYTVEDVVLETEFQGKTTQHTMMQLWPVRAPRPVAEKESATYPLFTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQALSKFSNSDIIIYVGCGERGNEMAEVLADFPELTLERNGREEPIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDQGNNVAMMADSTSRWAEALREISGRLAEMPADSGYPAYLGAKLAGFYERAGKVSCLGSPSRYGTVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLSKSLAQRKHFPSVDWNLSYSKYLKILDPHYEKNNPGFIDLRTKAKEILQKEQDLAEIVQLVGKSALGESDKITLEVARMLKDDFLQQNGISEYDRYCPFYKTSGMLKNFVAFYDGSQRAIETNDMTFAQVRDATSDIMFKLSQMKFESPNVQSEEEIQAKFDALHNEIGETFRRLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSW1</accession>
    <name>A0ABR3BSW1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613083.1">
        <property type="nucleotide sequence ID" value="XM_066758635.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991013"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="354" mass="40247" checksum="1CDEFF92E8C2038D" modified="2025-10-08" version="1">MAACVASPTKHSHPAKYTYLATPPLTPAIPTTSFLPSGGLSAGISHVKSSSMDSVPSYAALRAHHAYALRYVIAKLRWEQANNLYLPGQDAVWNHDQMIIELEKELHNVEEAKKSLNKFPNCFAPVWFPKPHGPRTQEEDEEIKKLEAEKNKIIDEKLNQHFPFLKQLFIGPKTKQQARNDRLLREQLREGDFEDLSVLLPSANMKMLLAEQQKKAGAPKKDYEQQRMEKERAKIAAYLEAHPQSPRTINMSNPASVPMASVSSKFMGPLTKEQHVASRVKTSLQIKDQTLYEAQRRQRQIILGWLHKPWDKYDKEAAGLMETMAELAKERLDIKKKGTDLVEPKKNEKVIAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT28</accession>
    <name>A0ABR3BT28_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 12 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614292.1">
        <property type="nucleotide sequence ID" value="XM_066757908.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990268"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="9380" checksum="E0E2B43BF6B8BFCE" modified="2025-10-08" version="1">MATTPTMDEYRERIKSREEHVRESWIKAMEARIVRDELQKCYRGEGVNQLQNCKVLAEKYAAMIRDNKVKGYKQVDPDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTF8</accession>
    <name>A0ABR3BTF8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103256</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614140.1">
        <property type="nucleotide sequence ID" value="XM_066757756.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990112"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0249953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="152" mass="16965" checksum="129FA26191035C58" modified="2025-10-08" version="1">MSTTEQTYIMIKPDGVQRGLVGEIIARFEKRGFKLVALKLHTPTKEHLEKHYSDLSDKPFFPRLVEYMMSGPVVCMVWEGLDAVKTGRVMLGATNPLASAPGTIRGDYALQVGMNVCHGSDSVENGQKEIALWFPEGINQYKLSSQAWLYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTR0</accession>
    <name>A0ABR3BTR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614526.1">
        <property type="nucleotide sequence ID" value="XM_066757057.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989369"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="61"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="538" mass="58260" checksum="0F7983547D5F5E6C" modified="2025-10-08" version="1">MSDHALPADFTKSPNVQSPVDKKSMTTAQNKVEKGVQDHVVNVEDAPHILASLGQSRKNLLLLIFSVATFVDVCNVSGVAVAVAQISQDIKLSYSQIVWIITSYSLCFAACLLLAGRLSDLFPASIVFEGGFFVLGIFSLIVSFVTSNKYGFLILRGLGGIAGAMTVPSSYHLTVHMFPESGEQQKKLALLSLSGAIGNVLGLVLAGICMLANYKWFFRVLAIICIAFTAICFLLLPLTHSTRKLEGELPRWKRLDLVGVGLMMACLICFILSLTQGPIDGWGSASFIAPFILSFPLAIAFFFWESKIPAKSAVLPPSVWKITNIVITSLAIGIAFPFWATSQLMYATYFQEVMRWTPIKVAAAMLPQGVTGLIVGGLAQHIPQIITKPKFTLPLGGLLIIAAELLQIFSDGGHGNDYWRYCFPAFILGSAGAILTYFCTSINLIIYCPPEMAGVAGAWVQVMAQVASAITLAVQASFEGGGVADWNMAARRSFYFQIAWTAVLCIQFVIFFKKPSSPEEAHEAARRRIAESGKDVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU48</accession>
    <name>A0ABR3BU48_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614398.1">
        <property type="nucleotide sequence ID" value="XM_066758014.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990376"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="12">
        <location>
            <begin position="66"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="11">
        <location>
            <begin position="217"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0250211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="391" mass="42421" checksum="019FBAAF544C1E07" modified="2025-10-08" version="1">MSPVAFDEVSSATFNGAGLIINKGNASNAVEHIIDTNVLSRPNLALWVTKDHRIYQTEEAFPSCQPTECIVHVKATGICGSEIHFWKSGRIGDCCVTHDIILGHESSGQIVEVGSEVQDFKVGDRVSIEPGVSCWECNMCLRGRYNLCPKVKFSGTPPSDGTMRRFVAHPARFLHKMPDSMTYAQGALIEPLSVAYNAVVRAKPYLGQPVVICGAGPIGLAMALCARAAGASPICITDLEQNRLDQAKALGFDRTVKIDLGWDRLRTAEQIRRVMGAGCIPQIAFECTGAASSINAACYALEDGGTLLQVGCGKPEVELPLMAMGFREVNIVTSFRYQQSWPVVIRLVSEGVLGDVTRLITHTFPMEKTIDAFETCADRTTLAIKVQIVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU57</accession>
    <name>A0ABR3BU57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614154.1">
        <property type="nucleotide sequence ID" value="XM_066757770.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990126"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="514"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0249967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="555" mass="60792" checksum="34EEDEB7CAA5B6CA" modified="2025-10-08" version="1">MPGLGEIKQDVPSRPSQVVNLSGSSDDLQRPNIAADIHSDGKSQDGVRQLPWGAKWRSSAWFITLVVTLGTTTDILTYTIVVPVLPYRLQDTGYSNVSALTSWLLFAYSIGIFLCTLPVAYFFHKHPFRRIPLIVAVIILELSLILFMLATPFWAMVISRFLQGASSTVVWSVGFALICENVEEKNIGRQIGFAMAGVSIGQTIAPPIGGALYSKMGWYAPFIFCIIVCFVDLVLRLFVLERTDLRKWEEKRLGLAPGSLQPKVVDGQVIMSSEVEASPFMHLTTAEKARLSGVELSPWQVLIALGSSPRGMTSFLTMFSFGMIIGALEPTLTLHVQSVWNKNADFVGLVYLAAAAPTFFCGPIVGALADKYGAEWIMLPSIILTLPWLPLMLLNKSLAGFIVFFALAELFANCAMAPTGLEVTMVARKVEGVSEIHQFAAMNIAFAISTAIGTIAGGQMYDHLAKGWVAAIWFCFAMAGVIMPLLFFFAGNKSIYQRCFHRGKEADAKMEEAVAEAGVGRQTEDESTRAAIERQSTTLSSKEKFDDKDVNSCHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUA2</accession>
    <name>A0ABR3BUA2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Saccharopine dehydrogenase (NAD(+), L-glutamate-forming)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102699</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614708.1">
        <property type="nucleotide sequence ID" value="XM_066757239.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989555"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12189">
        <property type="entry name" value="LKR_SDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="7">
        <location>
            <begin position="217"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="921" mass="100565" checksum="6904E23189807443" modified="2025-10-08" version="1">MRSFPLTRSPFSPFTTRRCLTTLGLRREDPSRIWERRTPLTPQAVQNLLADAKDELRVEVESCKRRCFSDALYSDAGAKIVSSLSKDVDVVLGIKEPRLADIRYLVEDSKNEGKKRTWMMFSHTHKGQEYNIPLLSAFLHPTQTLIDHELLTAPVPGKDDEPQLKRVAAFGWFAGAVGTGEALSLTGLALLRRGLATPLLSLSRPYSFGSLAAFKEALKKAGEQIQSSPDLKGHEPIVIGVTGAGHVSSGAKEMLNELGVVWVEPEELAELRQSGSPNKIYACAVTPASYLQRIEGGIFDREEYYKSPDKYMSIFAAKIAPHLTALINGVGWSKGFPRAITSSSLNKLIEKENGKQKLVAVQDIACDKEGGLEFVDQFTTIDHPYFEGPGDILISAIDILPTELAADASTYFSSALYPYIQGLLFPSSQGDKTDIADTLSRAAIIKDGVLQPQHEWLGGRIEQWKTGGAVAPDSLKQETLRKGGKKKVLLLGSGLVAGPAVDVFAARPDVHLIIASNNLAEAQSHIRGRPNVEAVALDVADDAKMSEAVEEADIVVSLLPAPMHPRVAKHCLDHSRHLVTASYNSPELQALHPQAVEKDVIFLGECGLDPGIDSMAAMRILERVKREGKQVKSFVSWCGGLPELSASKGPLRYKFSWSPKAVLTAAQNDASFKLDGKHVKIPGNELLARRFPEVKLWEGLPLEGPVEGLTDLFRGTLRYQGFSSLLNSFRLLGLLRSDPLPGSPKSWTEFFTMTVERELGLNKALKGEDVNSAVQDLVGEGSKDVLRALKLFSLFPGSDTSLLPLPKLPTPSPIDLFAHLLFRKLAYLPDERDTCLLHHSFTISTPSGDTQQVTASLRHIASPTQSSMSITVGKTLAFAALRVADGEVKVRGVTGPYEREVWTGVLSSLEGEGVVIEEKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUD9</accession>
    <name>A0ABR3BUD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103724</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613608.1">
        <property type="nucleotide sequence ID" value="XM_066758206.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990580"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF15">
        <property type="entry name" value="VELVET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="5">
        <location>
            <begin position="11"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="188" mass="20995" checksum="DC92207F32AC1375" modified="2025-10-08" version="1">MVNPSSHVPQNFISRTYRITPIQQPLKSAAFEKAYLSRLPLSPPLIIQLDCWDAQGEQIIPYDELPFLVCHLSLETPNGQDAAIVTSPDSEPVSMLYGTLVATPIEMDDQTGAQGVYFVFPDVSVRYVGRFRLKALLMRITGGPAVHVCVTRTFEIVHTKDYVAPPITALTRHFDSQGIVRFGLPRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUL3</accession>
    <name>A0ABR3BUL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614817.1">
        <property type="nucleotide sequence ID" value="XM_066757348.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989669"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="294"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="584"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="684" mass="74404" checksum="E804BC2DAB402447" modified="2025-10-08" version="1">MSPQQPPNPPVTSHNAQFLQSHDLVASLPTPYLRLLVLFARPIALLKHVLEVFFWSPGRRVESWMVIGAWWALCLGSQSAFRFLLPPLIFLPLLPLATLRFKSTQKRPTENSPSSPATPDSLLLALSDLNEIYALLPISPLPAMSDVYARFRQLGPVRLIRGLVVLWGTWLVLGQIVVGYKTLLALIGTIILLLPSPPLAHFINLLSGSLFFRQAVALAFLFTFGSPPETSYRFKLNFSLWGWFKSKWTASRRPSLAFPSRPKMSSKALSGSALEVEGEKPEGKEESYVKVEAPVYFRFEIHENQRWWMGLDWTSALLPQERPSWCDSHLLPVSPPQAFTLPAPVSVIINTATMKDRYARVMRSAEWKWLDDDWSIVRSGPGANAASSTQTTPILPSENDPDSGYSIPQGQHHNQPQSPQARTAASRPSSFISSFGSPISSSTVEDATSSTGSRAQSIAEQAFTKGLERLKARAVSGTAASATTGSPRRSVESVRGRTGSYDATDEESSEGGQSTQVGQPAGTAPLPSETIPERDAATDADGWVYGDNKWEHMGSKGGLGKFTRRRRWQRRAICIETVHKLSPSDDPAISIPPSTTESGVNTPTPSTFAAAPSSPLKSKPAVGLSDALTKGTSASEEASEPVRESTIPDHKMGSYGASSSGSAPVSRDEMLRMRLKKAMGSVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUT7</accession>
    <name>A0ABR3BUT7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614903.1">
        <property type="nucleotide sequence ID" value="XM_066757434.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989755"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="247" mass="26775" checksum="9EF6923CFA436D54" modified="2025-10-08" version="1">MATVTAAMDDLIASLSANMHVSQEGYDLKALHEFLAQSLPLPFPSPTAYAYPVAPRPHSLSRKPSSLPSYTYPSPSPTSLPLPYTQAPHPPVSYERPQSNQTPGQRPAPPRRASSFGTVPHSYAPAASAYQIPEPSYAAFESDAFAPAWQGAMQEAEAEDPWARIRGAPTGDFGFAAAQAQPQITDRTGKQPYQFEHSLGGSGQSQQNVKAAQNNDAIGMDMDEDEDMEDNELVESMMECGDEDDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV18</accession>
    <name>A0ABR3BV18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_102991</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614962.1">
        <property type="nucleotide sequence ID" value="XM_066757493.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989847"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="12">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0250775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="89" mass="10088" checksum="AF9069C7F69858F6" modified="2025-10-08" version="1">MDFSQFNGAEQAHMSKVIEKKQMQDFMRLYSGLVERCFNACAQDFTSKALTTNETTCVQNCTDKFLKHSERVGARFAEHNAEQMQGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV76</accession>
    <name>A0ABR3BV76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613893.1">
        <property type="nucleotide sequence ID" value="XM_066757509.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989863"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0249706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="377" mass="40880" checksum="0E48ED109CCEC7FF" modified="2025-10-08" version="1">MNGYYEPQQPQPTNIEIPQGPTNQPRLLLRNLNETDATFHLSGVELAYANSLRRVMMADVPTIAIDQVLFTQNTTPLADEMIAHRLGLIPLISRNVSKGLRYTRDCDCDEGCYYCMVTLRLKVTFSGNDGEQFMRVTSDMLEVVPSPGGPPPPNPYGPPPELSEEDRIIINNRDPEMGQPCGKGNPSIPPILIAKMGKGQEIDVLCKAYKGIAKHHAKWSPLSTVAFEYDPYNKLRHTTHWFETDERAEWPLSSNAAFETPPNPAEPFDYNAVPSTFYFSAESVGSIPVRSVVEQGLDLLIEGLANVVLGVQKETGGEEEEGDDGAGADGGVGDGMGIGMGGGLVEPNIPTGMGQDQIVMGSGYGGYGVQQGYGGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVC3</accession>
    <name>A0ABR3BVC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614235.1">
        <property type="nucleotide sequence ID" value="XM_066757851.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990209"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="29"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="287" mass="32850" checksum="51A3BF11FB4D796F" modified="2025-10-08" version="1">MSKAVLAAAEKTKSKDKAGASEGVKPRKDKVLMLSSRGVTQRMRHLMRDLEALLPHVKRDSKLDTKSSLHLLNELADLHSCSNTLYFEARRHEDLYLWLSRSPNGPSVKCHVQNLHTMDELKMTGNCLKGSRGLVCFDGSWEGEHWSLMKEMFTHVFSVPKTSRKLKPFIDHILLFSLLDNKIWFRNYQIIEKDPLTPSGPPQSSLVEIGPRFVLTPIKIFEGSFGGPTLFSNSEFITPAAMRASVKRIAGEKYRVRKEGEKDREERRKRVREDVEEDELARKKVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVH0</accession>
    <name>A0ABR3BVH0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613998.1">
        <property type="nucleotide sequence ID" value="XM_066757614.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989969"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF3">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045359992" description="DUF1748-domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="7663" checksum="594B0481D0B7F92D" modified="2025-10-08" version="1">MVFGRLIHFTFDALAVSTILAGVKKTTGFSPATDLIPDSSIKSITDSYLGAGTTIFDIVSGQAVTSQYFKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVH1</accession>
    <name>A0ABR3BVH1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614878.1">
        <property type="nucleotide sequence ID" value="XM_066757409.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989730"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="229" mass="25471" checksum="D8458D145602196E" modified="2025-10-08" version="1">MSTSTTPAPASGSSNPSLINKWLPSNPFDLPETRELIAQKVAMGEITDHDVAIMEKGYKWMIYTPPATAISFTFLIWQLMKKQYPRPRLITRLFWGGLSAGAGGLLGFGAAGVAAAMEVEDEVEDVERKSLIFEEITEHSRALQQSRLALSRPAPPPAVTSPSLTPAMRQAANRGESRLPRDFEFPNEKEEERKERERRMLEGLKLGKERVEEETKGTLGWVKGLFGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVN6</accession>
    <name>A0ABR3BVN6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="1">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614355.1">
        <property type="nucleotide sequence ID" value="XM_066757971.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990332"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="3">
        <location>
            <begin position="51"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="388" mass="40827" checksum="9397B4FF9CEE87B0" modified="2025-10-08" version="1">MTSMAAALAASLPAAISRQATPQPAAQQPSKVPQRLEGVVDVEAAREVENVSLSSLVFLKMMKHSTDSLPAPPASVLQQDRNPPPPTELSSHVDALGVLLGLDLDGVMEVEDCYALPGGETSLGPNSYSARLLSRLGTVATPDSPVGIYLSTHNGGFATRVSIELLSAVEKAAGRGKAILVVHDASRSNGGDLSVKAYRLSEGAREAAKLGRWDGQVLTEQGITASTLLTSIPITVSSPSLVNAFISTLNTPSPSETAAPPSLTNPSVPLPPSFAPLINPLPGSLTTYLQNTLDALTLHSHEANNIAFLTRQIAREKTKHEQAIKDREDENARRRKMGLSEFPSIPEEIRGGTKEPSRLEMVCLGGTVEGIAKGMAAEAGKGLVRAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW93</accession>
    <name>A0ABR3BW93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_102024</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615352.1">
        <property type="nucleotide sequence ID" value="XM_066756575.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988882"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0252632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="598" mass="66248" checksum="2E370EDFBA09B73D" modified="2025-10-08" version="1">MMVYPASTPPHPSLPLIMAQIQTSPPSVSPTRTRCLNIVLSLLPFLVTFAHVLLSPYTKVEESFTLHAVHDVLAYGFNPHNLRLWDHVTFPGAVPRSFIPPALLGILVYPFSVVTVAAGVIKTKFGVQILVRLVLASLFSYSFNKLAYSIQKTFSVFVRVWFTLLSLSSFHIPYYAGRTLPNFMALPGVLWSISHVMMAQTAISEADRVASLRKAVIALTALATIVRLELALFVIPLALSLLINRQAGFGQVLKWGILGGFGSLSISSAVDYHLWLPTLSHPSFPFKSHFQLFWPEFSGLIYNAVEGHSAEWGVMPWHYYLSSSLPKLLAGNASLVGIAMGGWLLNKIGFDTVVKKAGGWDRLTGIGGVNIVIKVWALSVVAVIGGLSFLGHKEWRFILPVLPIFHIISALSASSLWSLRPSKLRNFMRLFVLGVLGLNLLATIVTTLLSMANYPGGEVWKVLENIPGLHKQNASIYFPSYPLQTGATLFTFIHDHSVDGTGHLGPWSTFPEVKEPRWIYNKSEDKMMEDPLSVWESGIDFVVTGDYDQFLALPNKWVQVASVEGLDSVGRKPGTYRVEAKWGRKLVVLQRRESIQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWG4</accession>
    <name>A0ABR3BWG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GLTSCR protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614373.1">
        <property type="nucleotide sequence ID" value="XM_066757989.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990350"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701:SF1">
        <property type="entry name" value="UP-REGULATED DURING SEPTATION PROTEIN 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="851" mass="91096" checksum="554E31C7794C82FE" modified="2025-10-08" version="1">MTDQNKPRPKVTSHITSTPSHSPSTTYKASIRAKVTPSAITASQTPPGASSKASLKSTPSSSSLRAHVSASSAGTPRTGARSPLQRTPSTPAPVPQARVTKPFQAQRSPLTPGFAPSSGRPSSSSSSVSASGVASGTPVAVPRVRAAKSALGLSSVSNSSASKRKNNTESGTGSRSRSRSGNDDGSEYEQTPDAQARRYAVDKATTTVGTNGRIDRAPRARVKLQPQPQTQAQTGLQPKSSSKSTPAPSTSSPSSSRSSSRSAIHAAGTADTPTPPVRPANTGNDTENGSGSPPKDSNSTTSALGIVNAYLSSSPWPRLPSPEHPSAEREPLPHAVLHRLLHHHYHLYTGPGLDSLPLERSRSSTDNLESKAYTLDKDQALNQNQNQNQNQNQSQNQGSHLPPHVPYYLLTHPTASAPASPIHYSQLQDPNPDIQAQDQDPNLPSATSTTTSFTMTRRTSKPRLPPMVLHPSERQQALKEGRKIVGAASVGSGMRMMPGSPEMKTVELPALTPRVPGTPVLAGQGNGEWKDDELVEEVEEEWEVEGEGEGEGEGENGHGNGEEYKYRYENGNDNEDNHEDEYEHRYEYNDNENENGNGEIYTTKNGYGNREKSTEQEEVTNKTGGEGEGIKRGRVENEVEIEAGTEEKGKEEQEVDDMLGTDAVEAKINRKIADLEISNASLLAINQALEATKSKQRAEIGKLRRRLRETLAFPHLSAGGASGGSASSFGRGFGAGFGGSHSNSGLDLGTSTLEDEPEPEHDFDLFLLHEAEMADPQLDARWCKMEDLVLGMKKAAEEAVRKGEEDGSREGRGRVLGWAEMEEMRDMGDGDASFTSEGNGERSEEEEGTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWT6</accession>
    <name>A0ABR3BWT6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615578.1">
        <property type="nucleotide sequence ID" value="XM_066756801.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989108"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="4">
        <location>
            <begin position="1126"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="595"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1414" mass="159349" checksum="962A8115681FD8C5" modified="2025-10-08" version="1">MAHKDVPQNAQRVRMVTPFSMRCNRCGEYIHMGKRINANRETIQGEQVDGLNTLRLHINCSMCSSEITFKTDLLNAEYVCEDRATCNWETEVHNDDLGSASGGEEQETYGGGLGRYRTGSIRRTQENSGGKERELMAQMADLKERNKRLEIANSTLLAALRTRRTILKPLDFSRPNAEPPVDERIHQLLSTNSPLSDPDAHTILEYYQEHDLCMPVVDDWLDNIWKLLNLFYLSSHDLPKARRSLALFMFNAIYVHIEQLSELRNKFVSQVIVPFLEKTLSQQTDDWFRQTALDVLVKAAVIETFEGDEERRQARAKKKENELEEEDAAALPSQGMKAAAAAGSFHAMRNIIVTQATAVRCRREDLVLPKVEEKSESTTPPSIKEPPSISSRESFSSSSGFKGLMSALSPPSRTKELPSMSTPSIAPSIASSMAEDSQSADHSPTPTPPPSHSTCPSQIAIRSLIAIFNQLAFHFPSSSPSLSKSTRTLASSRCIAVYRDLLGLLYPTRHMSGDITPASRVASVHASCPKARVIILQFLFRLRADSTHRIYIRRKIDEVVRPFADILSRTREAVETQRANILADAEEARARLRARQMREAGSAPRETMRERASTASSRTRSRSRPGHIDSNAADTYNPLWQIPDALSFDMPAESISSQVLLTYDPDHPSLRVKDEPPVEGVWLPVSEYVACLCEILMHEKNWEIVSYVICFLPLQLGSRLFFRGVRATREVRKLLKVLCDTIPQDNRIERRCKHHAFVKRPNVNAVIYQALTILISYKDDLDSKECDTLIATFEMCLESNTIVAKPCIQALTLCVFELEQSIAKRLLPIISKMRDINLTSGIAVHLLEFILALGDHQSLFRNFTDAHYKDVFTLVIDYIAEHNARSDELPDMTSDKRESYTLSQHVIGLAYHAIYVWYLALKLSLRPDLVRHIITKLLQSRSIRVATDEMVEVCLDWLARYTYGNPDPKPTSSLLNEMVARESGESDPPKKQSWYLGNAILTITLHPGSGWASITSTRPTGATELIARLENLPLSEIDEDGLDLFVLPNLLMENRGLIMKDEEQALFTPLSTSSDSAGSSTPSQRRKEIAVDPAYFAIQLLSYPADSLDSIHGRPIPNEERFNRSLRNIELTPVIDTAKLGILYVASGQTDELDILSNTDGSPFYREFLAGLGSLIKLKGQMDIFTGGLNREDDSDGEYAYAWWNDLIQTVFHTATMMPNHAHDPKFDKKKRLIGNDFVKIIYNDSGRDYKFDTLKTAFNFINIVISPHTTPETYAPTPYVEMTDPETILGVRTRDDYFKVIVQRAPGIPDFSPVGQLKILSKETLPGFVRHVALMANDMAARFAHIRNASDPTEAEYITSWRSRLRAINRLKAGLPPVEAKIDSEEEKKREEMLQDFTKLLSDQPIANLNEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYQ6</accession>
    <name>A0ABR3BYQ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615341.1">
        <property type="nucleotide sequence ID" value="XM_066756564.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988871"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="691" mass="76395" checksum="A0F12BD11B705B08" modified="2025-10-08" version="1">MADTSLFGAYTKAMLDPADELDGDYRESPRKKPRITLPRGHACVACRQRKLKCQEGIRPCITCVKADIDCRDEEIPRKKPKHVILEERVAELEGLLGLQKGQPVPRNSNSSSTAFDGHSASPTSSEHFIPEHPQVGSNYTVNSYPDYSPLWSVTSMSTPPSQIEIPPGSAIELSLIQFILPYTPHLLLPLHPQRFLASLSLPPEDNFRPHPALLYTLFSQAVSHLERGIPPPCPPDRPLDLFPSLSPPFPLPALNTGFILSQLRGASGPLLARARLELDQGIREVDRPFDLTRAAIGIAHALYRRGNFVEGWTMPVASLVVACGLHRISGNCVPPPTNSKGIPGLPQPYAHPDYYWNAHTPSQVIPDRQELRMRPVLIPPARDEIEIAERVMTFWAGKQQMWISSGGWGWSDPLPDAECTTEWPWGWGHVEVRAVSPLERYTLNDIHDPDSNIHTGAYADTTYTLAMKSMALLCRAGRLFDLPKIPQPTSLSNEGSFPLLPHIPSLEDVESVEICLALFRQHIPFPFTFPSALSAANGPAMASASLDTEVYDGPSDPWWILFHFNLYAAEMLMWREMAFHRPESSGAALQCARAIVNLTGSIPDEKWANVDMMVALSISLAARLLVKEAARFQATGALTAASHALADAGILQNCLDGPFNKYMEVAGGMFSRIVDNVREGRTEKNGEYERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ04</accession>
    <name>A0ABR3BZ04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Regulatory protein ral2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615816.1">
        <property type="nucleotide sequence ID" value="XM_066755530.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987827"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="579"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="699"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="795"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="880"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1021"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="982"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="754"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="890"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="912"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="924"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1036"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0253595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1073" mass="116517" checksum="F724B8AF65713B3D" modified="2025-10-08" version="1">MDAGTAHVMSWSEPTKGQVPPPLTGPSITISPLSAPHPPTIFLFGGKSVQTRRLTSEMWAMDLSTRIWERVDAGPGPGPRYFHSMDVWEDKLVCFGGMSDSEPMSVHNDIWFFDCISRKWIPQPSPSDDASLGIDAAAQDQALIPSARYAHLSAVSRDKLVISGGQHSDNTWIYEINVYDLKSRVWISKTEQPQADGMYSKGAYRSIATSSKKRVQRPQQGGHLKSTTAHTYSVDEKGEGGDIWCYSNYDFAKVRRELDILSPESSEHAPSNKHAPPPEFTIRDESHRMRGSSQPQGLRFPTGGIVGNSFILCGLYLASVSGAFSIWALNLETMTWKHLEPSVLSNGSWNRALVWADKAKVLVFGNAQSDLASDYSRRAVNLDHIAVISLEAFGIYQPPNLVVPTKVQQAGLSMLDEKLASDFEVICDDGRRIKCSRKILSERWPWFAEQERELAGKVQGIISDAPVVDINDTLLGSFTPARLAPNNLMLSEPFPVCVALLQYFYTLSLSTPLQNRASVLSALLFISKQYKIERMNRIVVHALHERLDLSNAVGIYEIATLAGEQCLQVRALNIIHSAKSGSSRDHNRQNPGSAVPGEGGANDDSTPGHTQLGNPANGVPAGATRPGAIDAPVKRARADSMTIPENMMSSSPQLNPLQDDDDKISALLAALDVSAKEITTLPRQRRVGHRDSDRYLISFQSSQSPISPPLPSIPQRSHMRLPALSPPPLSRLPSFPHTSDPAQPERSSFGRPCSPTNSDVTSNYPQTPSESLHESWILPQHRDWSAFSGLGGGLMDSRSSSGSGMGLPALPEDDAFNPRPRGSLGRTNRDAFVHPFSTQKKPSQAIVEAAGLSQPSTLQNFDGLQQTRTDSPTMHHCAYDSSSMRMSPAPSISRTPSVSSHSPSVLTPPPSCSSKNTRHFSINTQSSGASNSLSSTSTAWGEKIGEPLLGAQTVTSLMSSAFDCGSSISSGSTGTSSSKKVAKAEAKAIRQAEKAAKKAEAQAHFEALRADQTKKMALLKAEAQRKAETQAAKEQTPSEKSLKREPKSKWGKLANGFKDAVLFPDGGPKSTMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ32</accession>
    <name>A0ABR3BZ32_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615846.1">
        <property type="nucleotide sequence ID" value="XM_066755560.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987858"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0253625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="120" mass="13422" checksum="7C3EC4E1C5A38446" modified="2025-10-08" version="1">MTEQIFPSAFSVLISSLPTEDGTTTLSDMILLGMMTRPRSTFPYRIRPPRTTFYASGQSGTLSKQVSPFSRQCEVRGTVDHPVEQQTPAHPPVHKPYRTDVCVIATLPSPSKVWITYHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ46</accession>
    <name>A0ABR3BZ46_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615861.1">
        <property type="nucleotide sequence ID" value="XM_066755575.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987873"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="80" mass="9025" checksum="711B64E12BF45571" modified="2025-10-08" version="1">MGGGAQYPYPKEVWTPSGGWWSRPSNWKGNTAICIAGITIATFGVWRLSANREERHVAPTRPIPSQMWSRQARELGVRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ98</accession>
    <name>A0ABR3BZ98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase mitochondrial F1 complex assembly factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615314.1">
        <property type="nucleotide sequence ID" value="XM_066756537.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988844"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32430" checksum="C0B04FBA8098A162" modified="2025-10-08" version="1">MASLRIPSRPLLAALRHVPRACRPATIGARTLSTSFAKWAVVKDGPPVTQTNRAEHTLRRFWKTVNISSTPSDGFLINLDHRALKTPFGAKLEIPKERRLLAALIANEWENQDEVLKQHALPVTSLASRAIDGLSEGPTRPAVIEALLKYLETDTILYPDDAPAPLVRLQKEHWDPLRAWLKEDFGVELQLAQGFGAVKQTDDNVEKLKKVVEAMDGWELAALERAVYATKSFVIALALCRGRLTAHEAAQASHVEVSSQIERWGEVEDTHDVDYQDIRRALGSAACLLIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZJ5</accession>
    <name>A0ABR3BZJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_101188</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616032.1">
        <property type="nucleotide sequence ID" value="XM_066755746.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988046"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="823"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="854"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="883"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="13">
        <location>
            <begin position="1175"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="110"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="963"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1019"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0253811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1233" mass="139230" checksum="D8F2D747A559F8B5" modified="2025-10-08" version="1">MADSPETRKKEQGKIIRLAYFLRRTSTDTTSTMPPPSSETPFHRYSHLDQISPSDTQENSPVDGNHDPRRQSAGFDHHNYPNPYAQRDACAVSNHPQSTNFNQQPYLHQDRSESFDEPVYEAPPPGQNVGYEDAEPNEHEQHDSTMWSERPSYSTPYDSDIKAPLDPTPYTPDLEADGMVVKEKKVLATEVMATSKARRWWIRITWMMTWWIPSFLLVHLGRMKRADVRMAWREKLTIFMMIFLSCAVVLFYIIFFGKLLCPDSDKAWNETELATHQGDDDYYAAIAGKVYDFYKAQHSDLSSYTTSSELMLEFAGQDLTNYFPMPMTVYAVHTSGPLQTVENTKLNDINWYTDTLNPALEHYYKGYYVFDKSEIASGADSDNKYWAIYNNKIYDLTNYIYTVSYYSSSSGTDLPNYSFLNSDISDLFQTSAGQDITKDMNEKLSALTAEDAANQMTCLNNAFYLGELDFRKTPKCTVQNYLLLAFSIILIATIASKCEESLKRTIDSLAGLNYDDKRKLIFIICDGNIVGSGNNRPTPRIVLDLLGVDEKLEAEPLLFKSIGEGSKQLNYGKVYSGLYEFEGHVVPYIVVVKVGKPSEISKPGNRGKRDSQVLLLQYLNRVHFDAPMTPLELEIYHQMRNVIGIDPAFYELIACAADDQQIIGICGETKLANENESLTTMIQVYEYYISHHLTKAFESLFGSVTCLPGCFSVYRIRTAEGGRPVIISSIVIDEYAEPNVDTLHKKNLFSLGEDRYLTTLMMKNFPTFKMKFTPDAIAHTVAPSKWSVLLSQRRRWINSTIHNLVELLFLPEMCGFCLFSMRWVVFLDLLGTIILPATCGYLIYLVIVVSTGKAAIPVISLAMIGATYGLQALIFILKREFMLIGWMLVYILAFPVWSVFLPIYSFWSMDDFSWGNTRKVVGEGNQKTVVIEDDEPFNEGMIPYRTFKEYEWNAWEAASLHSESPAPSEKSLRTTRTGQTCRPHPNSIHPPSFHSSASELPSGADYWRDSSTLGMAHESRRLYQVSSDPSMRGDKPINKGRKPQVERMQSMAGMSMWGSGSVYDPSKQAVGGPAFLHPLMAGNSLASQPTFYPPQTHYPMSMYGSPMMMTMGMPMMGLQHIGNANVAEGTAGPRGTMMTMGLDDQSRVTSFSTGGPVAESGTARLAGLSINEEEEVQDEEVLAKLKAWLSKQDLMSVTKRQTREVIYTLFPNASLQSRARWLNEHIDKILSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZY6</accession>
    <name>A0ABR3BZY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615917.1">
        <property type="nucleotide sequence ID" value="XM_066755631.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987930"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="380" mass="42233" checksum="FE64BBF197E8712A" modified="2025-10-08" version="1">MRIPPEAPQLKMNTFAHPPPWGAYITYPPGAVVAYHATIWRCESSHTSWEEPAGAPSSNLAFWTPIGVLGPNISTSAQQVSPPSYTQSLNTQAEKVPPYPTSIQSSSSHNVGDEKPGFGPGHSGALGYLSDKAGDAFRGAIINEEENESKHEDNLKDEARGKRFWRVGGVGIWAYGLDRKEESTREKLWREWSDKHDEDDWINISRKRTKFYNESGGRHVRPLFSWKLVEKGERLPVDALPIGNEQDGAVLYAARAWHQGGVHLGKAGHHLYKGASIPYGGGEISFDTYEVFCGPINEPHLVKWMTFPHGQIAHVEGWQPVEGGREKDGRALLLAKGFYDNGQHPGKIIVRDDHACVGYGGGEVWVRPYQILAYADPHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZY8</accession>
    <name>A0ABR3BZY8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616170.1">
        <property type="nucleotide sequence ID" value="XM_066755884.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988185"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="605"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0253949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="676" mass="74398" checksum="1A89B64A0D9B681A" modified="2025-10-08" version="1">MQAASPAPEPPATPPVPLPLSLPVLPPLCHVPSPGPGAGAVPAAYHQLPDAPTPSSSSSPGRRGFYDDPQHYNPAPPFVDHTEDQMLREDDNRLRARRTSATLSSSPAANISPSSLSVHRRSLGDNTQRLPSDFAPSPVPPHVNPVPPYLDYIEDEMLRNDHVRVRSSARGNSVGTFSSEHVPAAFPTNNIAPSHASSSSSTSAISPSSRHQPVASEGANDRWSRDRLTDRRRAMLASQRDDNNRPGPWTQAWGRAADEPFNAETNNDRYWDAEYSPAYIERRPLQQLASSSSSSSSVRPSPVVANMGGHDRQALNRDINETVGRRLGSLRPVQMQNPSFPLEASTNTLRRREVSRGAHRAAATAAATASEGNLWGELERDNRSSYTTLPSLSSLSSSFSPSSRQSAAPSANNGDSGITTPTQESVFRAYVNSNHGQDEDDDFGDGFGDDFDDDDDDDDIDDEDYDDENENGIGEMLNPDIMREVYNLLTARPVQPMATFSGPGMVAGEPIELIHAHAQLQQQHAHVASAFGRIFRQRPPRQSLEDLRLSPQMDDHTIQETLMSAIKGLKHVSDGKKRRMTMGILENITWAEFGEREGMVRDEYCSVCHDEYEDTTEISITPCKHMYHKDCLCTWLNTPKISSCPMCRRDLALLAAFTNMVPSKTVDEAIPYWYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C031</accession>
    <name>A0ABR3C031_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616218.1">
        <property type="nucleotide sequence ID" value="XM_066755932.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988234"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="161" mass="17510" checksum="631854301D6375B9" modified="2025-10-08" version="1">MSTRYYHSGPSGFAAASISSVIKAWGGHGGLGRDHLPHISDTYFKRSNLMVSFIRRYVPAEAMGCLDGSGGMFLWVRLQVEYHPQLCILSPEEISDKEIQTLIGEKIMVAPSSYFEIPGGPTTSPVLSSSYSLISRLPGLSNAIAAVSFRSTHNCTNQKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0G8</accession>
    <name>A0ABR3C0G8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)H:quinone oxidoreductase, type IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616326.1">
        <property type="nucleotide sequence ID" value="XM_066756040.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988342"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="17"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0254105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="219" mass="23309" checksum="3465F02BF12823F8" modified="2025-10-08" version="1">MNVRQPIKMSDVKKPVIIVAFYSTYGHISALAEEVIKGVESTGAIVKPYFIQETLSAEVLEKMYAGSSLKPKYPIITPNDLVEADGIIFGAPTRYGRLPAQVSAFFDQTGGLWAKGALVGKFVSLFTSAAGQHSGHESTAISSFPFFAHQGLVYVPIGYSEPSVGNVDELSGGSPYGSSTVAASDGHLQPTAKDLRIAAHQGKYFADFVATFVRGKNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0G9</accession>
    <name>A0ABR3C0G9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-actin capping</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616359.1">
        <property type="nucleotide sequence ID" value="XM_066756073.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988376"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0117">Actin capping</keyword>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50337" checksum="EC7514DD8112061A" modified="2025-10-08" version="1">MVDLSVEDKCKLAARLVEQTPPGEINDVINDIRAIINDDQALMPHVLPALRSYNLSQLHVVEHPELGEVPAHTSLLSEAVILRGSESERYVDNIGKNSFAFDHLTFTISDYQPYELPEEEETFRAVLAKSLEAYSKNHFPSGFYSVACSQFPLNPQPAAAPITEPEAVIPGGAAPAEGTPEAEGPIPATAEGEASAEPAVEKMDAEEDADVTDVVNELVNSGDLEPSSTPAVGDVGIKEDITDPEHLEELDEAVEEEKEREEEEERETGEGNAVEKTTEPKVEEEDGPKLPQEEEEEIEKKVEGLKVEEKRQERIENPVYTLEVVGNRYNPSNFWTGRWRTRWVVDQTAGKVNGTIQVDVHYYEQGNVQLATNHTASFPYPTEPNGSQSIASQIVTTISKIETNYHLELNDVYSELGEKAFRALRRALPVTRQKMDWDKVTGYTLGADLSKART</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0I5</accession>
    <name>A0ABR3C0I5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616365.1">
        <property type="nucleotide sequence ID" value="XM_066756079.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988382"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="269"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="508" mass="54807" checksum="E3E975793C7910B9" modified="2025-10-08" version="1">MDNTNDPTMGGLDALVAAASSVSAGKNRRQQPDNIAMDMIDPALHNESGDTSNAVETISSLLANPAVVSLIAEYNAKKGHRQVSLYTQLLSGSSGGQPPATPVQQTRYGRISRPPIHAPGTPGRINEHGGSDSQIQAIKDALENVSQQEGEGDVSYDSLVGAVVPSGAESRFWRPGGEGSGPTSWVGDAETLAQAADASHRAALNRAAAMGANVTGDAGEEQAKGNNRGTTEMSMSTDEDGRVPDKEGNLPEWPLPPSGKGGRKNMPRDELLARRRARNRVAAQESRKKKKQFFGSLAERLQEKEAAYNELETHCRNLEREIELLRKTVTDANLPLPNFTPEVHVPAAVSGGETPAPAAETPAELAFSELFNIDDNDDNDADFVPPSSPKRDSDSEDSDDEVDEEQPRRKKTKRAQEQEQEAEPMAEDEDEDLFLPIVDVPVPPRDSEDQQKLVKQAMTELHVDTPEQLMNVVKKMVETAEFGGVTEEQVGMLSKLLALGQAQGVSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0I9</accession>
    <name>A0ABR3C0I9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">I308_101523</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616364.1">
        <property type="nucleotide sequence ID" value="XM_066756078.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988381"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="223"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="494"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="750"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="812"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="383"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0254143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="838" mass="94249" checksum="027F731A675E0C89" modified="2025-10-08" version="1">MAPQPLKMGTSNQSKVDKTAPRSAAGLAKKAEKSKKRAVEQVEEASDEEFGDQGSGIDMSDDEEELDGDDEEEDEDEAFPEFDSELEDNDEEEASDEGQDEQDTSDEGEILEEDSGSESGYNTSDIERMYASDDDLSSEENKDLPVDEKLSRLIAKNTVKPDDSIGTDDKISRAKEGVGRLVPSKHVKGSFVREYDDYEAGYGSESSTEDNPNTVGNIPMEWYDDLPHIGYDVNGRKIFRPLQGDELDKFLANVEDPSAWTSAEDKLLQQNVQLSDKELDIIRRLERAENPDADFDPYQPTIEWFTGEGKERVMPLSAAPEPKRRFVPSKWEHKKIMKIVKAIREGRIIPNKPSAEKPRFYPIWSDADQHNAHVMYMPAPQLPPPKTAESYNPPEEYLPTEEEKAEWEATDKEDRKTDFLPEKYDALRKVPGYKNLVQEKFERCLDLYLAPRTRRVKLNIDPESLIPKLPAPKELKPFPIASTVQYRHPGDTRVRSVSTSPDGQWIASGSEDGVVRVWDLGNGREVWRWDLHAGPIQYVEWSPSREESLLVALVAGKIAVLSPLALVAPHIAAQTLTHSNTAFATSSATTKQGAGNEVKGTESVKWTRPSEKERERGVLVYVEVPGTPKQVTWHRKGDYFATVASDAANKSVLIHQLSRHGSQSPFRKTPGTIQRVAFHPSKPHFFAATQRYIRLYDLAAQKLIRTLQSGVKWISSMDVHPGGDNLIIGSYDKKLAWFDMDLSAKPYKTLRYHNRALRSVTYHPTLPLFASASDDGTVHIFHCTVYTDLMQNPLIVPLKILRGHRVIDGIGVLDLRWVPGKPWLVSSGADGEVRLWCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0Q5</accession>
    <name>A0ABR3C0Q5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616422.1">
        <property type="nucleotide sequence ID" value="XM_066756136.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988439"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219:SF1">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0254201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="107" mass="12284" checksum="F02FED1CBB5707CC" modified="2025-10-08" version="1">MAKSIRSKAKMASRARKRNMSHYAATEAARTQRLSNKLLGKDKKEGEDNEEIKEEQIEGDDAEMKEEPKKISTSGYRGSRKEQWRTARGMSARPKGSTKAKRNTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C243</accession>
    <name>A0ABR3C243_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transaldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616411.1">
        <property type="nucleotide sequence ID" value="XM_066756125.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988428"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF39">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0254190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="42650" checksum="36C1E4CDB709E782" modified="2025-10-08" version="1">MISRPELTLLEQLEAAGVKVDTDSMDPKVAANLPVKAHDMTSNQLLTNEQLKNPENKELVERTIRELKGANWFDIQTVLTARFAKRVIPYIQGRVLAQTTPTRAFDKDAIISHARAYDKAFQAEGISRDRYCIKVPATSAGVQAAKILNQEGIRTLGTSLFSLAQAIACSQAGMLSISPYYNEVRAHVDYNLWPDVADPATQHPMSFRMRHIRETYDRLAKETGKVQPLIKSASFITAREAMAMPELGADHATILVGCMEDLCSTSRLPEYRKGGEWQVRVRSELDKPNVKWATWSAPEPSVSKKRMVEMAKADPLSTLMEKDWKMASTDVDYLADGVLDKYNEEDEVTKVRLRDALELFKGGEEESRVEIERLQKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3N2</accession>
    <name>A0ABR3C3N2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LSM1</name>
        <name evidence="8" type="ORF">I308_100048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616528.1">
        <property type="nucleotide sequence ID" value="XM_066754627.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986906"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="135" mass="15241" checksum="76779094801DB674" modified="2025-10-08" version="1">MDALIPFTTSGSLVDLVDKKVLVILRDGRKLIGVFRSYDQFANFLLESCVERLHYKLEYADKDIGVLLVRGENVVALGEIDLIAEDMVPLQQVNLQEIEEKISAENKQRERDHAVKESVLSKMGFVNEGKEGDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3Z4</accession>
    <name>A0ABR3C3Z4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616627.1">
        <property type="nucleotide sequence ID" value="XM_066754726.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987008"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="903"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="999" mass="112200" checksum="A4BD27B577E543E5" modified="2025-10-08" version="1">MSETAALTARPQKTQTSLSMGPMTETPSPQPPLVYPQSPGNPEVGSSPKGYETSTSISLPPPKLLSAYLVKHPNHTVGKAIRTNFPQPNPLLRLIRRFKVKHSIISGLTEKEMRKYEERGEELRRKAGWKFEGEEGEGTVVSQLFWKMYISLLPTLDRDPLSGLVPPDLLGSTTTMPLSIISLIPDIMQHYRDVIIRARTEVFLATNYWQPSNSVNTVSQALRDLSAQVLKDGRPKVVVKIMYDRGSWEQLWNAHAPVHHSDWTPLDLPAKEDIKGLDMEVINFHKVLLGTFHAKFLIVDRKVALINSNNIQDRPNLELMSHFEGPVVDAFYEIALHSWYNRLSPPLPCMTKPYEPPRGPNGKAHYLFQDQNPYFDDIEILKAAKAARILLRRQTKDNEAEAVHHEGAGERLREAVRKVVDQQRQSLADWKPGEEFEARAQTAMKELREFKDRWSLGMGSRVNSRGPSRRPSKEKYHDEEKRRTLLAPSEADSSPTMTAEHPPKSKTYPLPNDRTGDVENSCILDDEIPFKNTNESDVISRRSLDGRHVNEEKGLSKHHVCFAPLEMKGVDGMGKIFPEAGMTESPHTSTIHLPLGMNQAVSSNRSLIEPDSETVAPQTGSHPQNRPIPEEDVTCINRLGDRTIERTSDIAATKPGVPSASKAESHHALESQIVEPPTSEGNEALPLSAQTPKESGETYERTKKHVEMSISQGESAEKLKEEEIQPEGTGSKRMFQLSKKFNAGALSDAWATVEDSDELDNFRPHVVHAPHDPFPIAMCCRKPHGLPGHHDIRNPQNAAWLAGFRYAKKKVFVQTPTLNARPIVRAVKQACRRGVEVVLLLDLGFNDKGESIPFQGGTNEEVVDRLYKKLSSEKKEQYLKVYWYTGKDQVRPLNAVKKQRNCHIKFAAYDDEVVIIGNGNQDSQSWFHSQEVNVMIDSKQIVAEMMDTLLSNQNTIKYGLVDSDGIWRDKDGHTLEHYGATAKGAFRGLSAFITFAKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4I1</accession>
    <name>A0ABR3C4I1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616813.1">
        <property type="nucleotide sequence ID" value="XM_066754912.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987198"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="369" mass="39480" checksum="42AFB2C6CCF9E3AC" modified="2025-10-08" version="1">MPVFAGSLLNKRKPELLEIGAALGLPTDDVRVTDLVKSIQAHLDANEAKLASNPTFKGLFYRKRSSHGNGGGNGSHTPERSSSPTIGADIKKFESSAAINARALTNKASDRLQEAADAAKVPLPETPVALSRVSDATHALSESVQNALVPASVPSGDISSKLQDIAQQFLQIQHKGQERVNIGIRHTRDAISTPQALTITALSAELLFLLGHVLPFYNYTYFFPPIPGKSGTLSSLVHSLFSWSPTFSWTVRLPEASGFVSNELWGAIAWWVFSTVLPPLALSTVVSFVPQKGIHRHNAPRTRYQEAHLPQPTPDPLVFALCRLAILVLPLTSAAPTSLVDALEMSGNLQGRALGAALFAGLILAAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4N1</accession>
    <name>A0ABR3C4N1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616716.1">
        <property type="nucleotide sequence ID" value="XM_066754815.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987101"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="93" mass="10326" checksum="E45FA63AC0628619" modified="2025-10-08" version="1">MESGDLVGKWINRTDLGDIAGSATSVRKDNKGTFRNKNGLSGPYRFMQWKFVAERMKECAALLRENGRMLEAQACSEKAGTIQNGVKKLPISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4Q5</accession>
    <name>A0ABR3C4Q5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100273</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616746.1">
        <property type="nucleotide sequence ID" value="XM_066754845.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987131"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="654"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="845" mass="93842" checksum="619C80076D5C7DF5" modified="2025-10-08" version="1">MPFPGQQRTVAPEKFKTVSPSASTHRRSGAGSAKFHSTTRPSTRASTHIGDVPSHVVALLQGKGHGIEIGIAAICLLTGQTAITQVADNASFDKTVQHLYSHPPNTIIVPDTMLQSGPAEVRRGNQRDMNVKEHLMNRLEDEYEIECIGVDRSHWNRETGRDFVEDLAIDDERKASTLMAIENKFYALCALCALFKYLQTWRNIEFPERSLRMKYMVAEGIMFIDIQTAKNLELVRNNLTNNATHTLYSVLNHCHTPMGMRLLRTCILQPSNVLSIIEGRLDAVHELVTAQEKLTALRSKLSTVSKLDLESIVAQILHQDLAQTDVTITDHRISLLLDLMDYLQSIKLINVELAGERCKLLDMITRCLSDKQLDNVFCILSNCLSRDATSLRKNRKHQNARIARLFAVKAGFAPLLDVARQSYQENLQDIYDLESEVNGKYGLNCQIENVGGTFQFSILSGQPESLLPSEFIGIEKAKNKIRFSSQELLKRCAKLSQSHQEVLLISGKTINDLIAQVKHDLGGLYHCAEAIASLDMIASFAFSALNSSYIRPDFKETLAIHGGRHPILDNLLGAGDCIPNNIYAAKGPATFQIIQGPNMSGKSTYLKQIGLLTVQAMIGCFVPAEYACFILHDSLLSRLSNDDSMEKWLASPRSLVLIDELGRGTSSLEGMGLSHAIAESLITRQSIVFFTTHFQDLGVILGNLPGVVKLHLKVQRNTKAPSPTEFSTSFAYKVAEGAAPMEHYGLEIAKLASLPTTVLQRASEVAAQLSELEEQGRQSNLGNTSMRRRKILWELRIKLKQVQSSSRLDNETLGEFLQNLQAQCYLDLRQCLEMAHTTISSSETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4Y4</accession>
    <name>A0ABR3C4Y4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616965.1">
        <property type="nucleotide sequence ID" value="XM_066755064.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987353"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22457">
        <property type="entry name" value="KH-I_Rnc1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049786">
        <property type="entry name" value="Rnc1_KH-I_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="115"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="273"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="365" mass="37737" checksum="DDD94439CB738FC3" modified="2025-10-08" version="1">MADSSPADNLSPKAVQEQLPSADAQGAEHQLSLRSLVSTKEAGIIIGKSGATIAAIRDSTGVKAGVSKVVQGVQDRVLSVTGDLEGVASAYAEVARLLLETPLSDSSLPPPPVGSFTSIRLLISHNLMGTVIGRSGLKIKQIQDMSGARMVASKEMLPQSTERVVEVQGSVDAIKTAVLEIGKCLLEDWDRGAGTVLYHPGAAGDAGVLAGGLGAQAVTGSTGGIRRTSVAAGFGSYSGDRRPSRGGSISGPSGVSGERKPSEGPQVNLNDPNLRTQNISIPSDMVGCIIGRGGSKITEIRRLSGSRISIAKVPHDETGERMFTIQGTPEATERALMLLYSQLESEKERRVNGSGSEAPASADFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C521</accession>
    <name>A0ABR3C521_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616984.1">
        <property type="nucleotide sequence ID" value="XM_066755083.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987372"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="278" mass="31465" checksum="625BE33087206E68" modified="2025-10-08" version="1">MSATKQGATAVHGSNPQYLIEKVIRARIYDSLYWKEHCFALTAESIIDKAIDLRAIGGVTDRQTPTPFICLVLKLLQLQPEKEILIEYLLAEEFKYLRALAAFYVRLTFRSLEVYEILEPLMKDYRKLRVVHAGGYSLTYFDEFIDELLTQERVCDIILPRLTQRSVLEETEGLPPRKSLLEDQESEREGSRSPSLPRYASRSPSRTPPSSPGSHGRSRSRSSVSSGNRYVSRSPSRSGSELGGEEGDTRDRYISRSPSMSPDRILEVAEDDVLEGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C529</accession>
    <name>A0ABR3C529_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100519</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616989.1">
        <property type="nucleotide sequence ID" value="XM_066755088.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987377"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="265" mass="29783" checksum="F0CC1A09E7CB839B" modified="2025-10-08" version="1">MAASLPIFHLLPDHHSSYPPSPTFSDPAFSAQYDSSFPANIDLSKSNHHPLNSYSFPTPPGTSAPPQYASRHIPSYPNLVPPNFSRGSYSAVQGGQDPTAFLGLDLSQPGPSTYHQQQTQAQTQPQPQHQSQSTAHHYQQPDHDYVHSDAEDDESLVRVKEETQDEQQEGDAQGVDDMDNEEPLYVNAKQYHRILKRRMARARLEELNRLVRSRKPYLHESRHRHACSRPRGKGGRFLTAEEIEALKRQEAEKESKGEEAAQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5A8</accession>
    <name>A0ABR3C5A8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aurora kinase</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617074.1">
        <property type="nucleotide sequence ID" value="XM_066755173.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987464"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="187"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="454" mass="49424" checksum="B799955904C90F0F" modified="2025-10-08" version="1">MSSQNVSGLMAGLSLYGPQSPKGSKAQQAGKTQGSSHSSQSQNRLPPVLKKYMNPGLVRPPNSGLANNNHPSSSYSDPSSRGPLLTLAGVNVSYPKSGTVSPVSKSKGAIGYHSAHGIHGAAHATSSRAMASSINPGAPKHAIATSSAHVMNSTSENGKSLELGRYDGGLEEDEANQGDVSGPTAKMLELSSVSDGAIPLSLLSFTIGRPLGKALKCLHKAEIIQGKVESQVRREIEIQQNLRHPNILRLYGYFHDSKRIFLVLEFAAKGELYKQLSRLGRFDEKKSSRYIAQMADALSYLHKKHVIHRDIKPENLLIGLNGELKIGDFGWSVHAPSNRRSTLCGTLDYLPPEMVEGKEHTAAVDLWALGVLTYEFVVGGPPFEDLSGNAATYRRIRNVDLHVPSWVSPEATDLIKRLLRYKPEDRLPLSQVMIHPWIKMYEKKRSTGSGIRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5B9</accession>
    <name>A0ABR3C5B9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617092.1">
        <property type="nucleotide sequence ID" value="XM_066755191.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987482"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="822" mass="93646" checksum="D62336D8581496A4" modified="2025-10-08" version="1">MKAGLLRSSSVRGTVLRNVSPIIPRKSGSIYQLLMRQDQTCASSGHRLLSTKRPLEGDGFESDATYLAHVQPLASSSTSPIPISQVIQILQQTSGDLVTLVQLVSDLEKGDLAYVQEALRYLLPCIGRRRMAVLLPRVLDIWMEKVDVEIEEGRVEQAQVQIWYYQIVKKLSHFINTHGESKHQSPQSPLPGNVKKQVVRLISHLIDILTLFPSTSIQRPCIKFSLLELLFRRRYLSTELRVILTKHCVEHGIELSARMWHECVMASLSEGDIKMVRKLEKKKQTALDKETEAQGYVLEGLRIQTKSKPRRLRKVADLISRLQIANTDLSYEKLFQALEPYLDPQLLESPPSLPSDLSADKELSHIAQHAWSVLLTRLARDTTVSADMLLELSDSMPAKYTTGRTLTPIMHGLLRRGEGPRAWSIWRELLSKESQSEKRGEKGLFVDRVSLSVGAQICHDIASLDSAIEMVDLWAHRPWQPPPVHGQMENSVYLDTQCVNILLTLCQSDGATSTAFRLWKAALPRWGVYLDHISLKILIDVARYHSIHRKSVQPDADVFKERLRQMVDGFSLWGHGHMEEGTAEVYDAYEDAGFAKGSTSVLLAPPGNSGAREKEDWRLEKPWQMARVIFRQVVLGNWPHLRETRSPLDEVDQSTFDKFTSLFDGDLHIPRHVSPNKLRELNQDSLPDPNARYTHIIPTASTFHSYISLLGYYNYPHEIPVALAWMKALSIVPTWFTMRLALMHICEAEGPRRWVRGWGKEGKGRLVRDEEIMRRWLEEWLLQEDSGGNGRLGDSWTDKVPSEEEVAAFRRMFAERNQRITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5E9</accession>
    <name>A0ABR3C5E9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617128.1">
        <property type="nucleotide sequence ID" value="XM_066755227.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987518"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="9">
        <location>
            <begin position="500"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1051"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="508"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1072"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1081" mass="119127" checksum="D4B5B5EFE8C2FEF0" modified="2025-10-08" version="1">MLILSRLRRLPPLFKHSTPTHPPVVLRMASSAAAQDHGNFKLLKSFPIGYAPITVSKWRSEKTGLTVVLGSHQAPITNGYFAIASEIFDDTGRPHTLEHLVFLGSKQYPYKGVLDQLANRAGSNGTNAWTANDHTAYTISTAGSEGFLKMLPVYVDHILHPTITDAGFVTEVYHINGAGEDAGVVYSEMQARENTAGDLMALEGQRSLYPPGSAYRSETGGLMHKLRVLTAQQIRDYHAEYYQPYNLCLVIDGAVPISELFDVLNNEIDPMIIANKSGSEPIIPADWKRPFVQTTTAESISISKPITKTVEFMEEDESVGEVSITYLGPPPSDYRTNLAISVLDSYLTQSATSPLSKEFIEISKPLCTAFSFYASDRVNKNEISVYISDVPARHLEDIAGLFQEKLRKIVKEEGIDMERMKRILRKDQRKLLEYMESRATEVLSDAIIGDFLYGKMDGKELPLAFNDMEDYSVLHSYTAEEWLALLDKYFVSAPSVTIVGKPSAALSVKIEKDERERIARRKEELGEEKLKALEATLESAKKESEISPPKEMITGFPITDPSGLTWVPVETAINNAVNDNVKSDGGEVQRFVDADGDRLPYQTHFSHVESNFVVVVALFDTIDVPVHLKPYLTIFQNALFSLGVKRADGTILSHEQTVNELEDLTVSQSAHFEFKGNFAEVMAITLKVEKDQYEQAVAWLRDLLAGAIFDSKRLSVIVAKLAQELPTEKRDGNTIATAWANNLTYDASKSSSQACELLNRLEFIPRVAEMLEKEPDVVTEKMEELRKHLLDPRKMRVAVQGNILRLQKPLSVLARSFLPIVEALPLAPLSTSQQTLTSLGKSPSKKCVIIPMPAIEGSYATFFATGPSGHSHPDLPALRLAASLLNALESYLWKSIRGSGLAYGAHVMVYPEAGLVGFNVYRSPNAMLAYEAAGKIMDGLVDGSVELDQDLVDGARSSMTYDYARRSETVLGAAGTAYLNEVLKGLGKNADQDLLKSLPGVTLEQVRDVISRYFSPLFKSETSIGAVTVSTSKADEVEAGLRKLGFETERKELPVLQGDDESAHGSDVDMSGSESGSEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5L3</accession>
    <name>A0ABR3C5L3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617189.1">
        <property type="nucleotide sequence ID" value="XM_066755288.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987581"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="352"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="770" mass="81763" checksum="E62AC219C494D2BD" modified="2025-10-08" version="1">MPASPKRSCSEKDIPVPPSNPSTPTSSSPNPLAPPTPVQPPSTRPVTRRQGLTRSRSTSYNMSSLGMATRRTSTLSASSSLPNIRSPPGSLIGNGDGVGLGITIPSRSRTTGTGMLLRTQSTPMLSTASHASFKAVVAAAGSTGCVEKPEKDCFDRKRLGRGKENIPPKRDKENDDNAPRKRLRMTSRGSFSDASGRRRSGSVVSVRSETSGGRHGSLAPSTSSSSISSWGTGRFPSPSPSDASFGTSIPDPPTPCRALGMLPSSSEVPETPTKSRINQASCLLTPPPSSPDLATEGAADFKPTGEANPYKRLKAALRLSTISGFTDNEVIIGREEEKAAISQYLIDEKNDKDVGMYVSGPPGTGKTALVTAFGRQKAEQGWRVVEVGCMGLKINDMWPRLGDELGCGKTEEEVTEFVKLNASRILIILDEIDSLMPPAPSTSPPATSHLFAKLFSLPFGSPNTKLIAISNTLDLTVRARLVLPNGLQPSVLPFKAYGAPEMSNIVNARIANANVRDIKIDSTTMTLLGRKVEAQNGDLRMCLGVLGSAISLAEAEWIKRRSQAANDPSEQVPMIKVAIPHLMKALTSYTAQLRASAGSIAGSTSAAGRKIKSVQLQGKMVLVTILIYLARSRAGMNGCPALGPSASPPGPPATGPDIPAAALYTTYSYLLSHSSSPFPPAAESDYQDMLSNLETLGLISLPFGSGKGTNTSANKVVLCVREEEVKEGMGLMEGQDKGVAEEEVKRVWEREEAKIQRVKQRLERGSNHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5L9</accession>
    <name>A0ABR3C5L9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_100269</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616742.1">
        <property type="nucleotide sequence ID" value="XM_066754841.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987127"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="11">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0255465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="141" mass="16064" checksum="AA2966741FA2D749" modified="2025-10-08" version="1">MATHRPAVLHDKQYSDPNPLPSNVPHVDELGVTSAPLKSASFFIGQHCKEVNEDFMLCRKVTRCAQELISKLRETCLTEFDAHWQCLEKNNQYFQACRKPEKALNQCVFTKLGLTKNIPGSPEGQPQIHEKKSPIYSRVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5P4</accession>
    <name>A0ABR3C5P4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617221.1">
        <property type="nucleotide sequence ID" value="XM_066755320.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987613"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="67332" checksum="389BBCA542DA02C3" modified="2025-10-08" version="1">MVQIEKRNSTAAEKQKKVLVVGAGAAGMSTAYHLSQHPNKFDVTPIDALDYCGGQAFSIPINKESHGASWCNQGVQGGSYIFHHTCTMFQRQGYKADPCELQVSFGKDETFWSNMFPTNLIVKHQREVRRLVWMLKIMRWFEIIFAILSLKVVFKLFWFSDEFTNAIALPMTALFLGTGNATPDVPAIMSERLCTSPSYGMWYAPNKDSVVDNQPPMIVFPNLSEFYDTWRKSLVERGVNVKLSTELVEVTKRDKNGVVVILKTSTPVKNGHKPDGEDQIASKIEENYDELVLCCLTDTAKKVLGKTASWKERRAHGSAKFSNDITITYNDSAYMKRHYENFYPNDLAVKTLNAIDQSSRIAYARKNFRPMYYIKEYPQDRSKLEMCFDCTNYQNQFPPDVPFDHHVFQTIYLNQSRDSHLWSDDEINKEKVIRKDWWHQFCHSYTHYLFVVPWMMFLQAKRHTRYAASWTLVNAHEVAIISGIAAAVDLGAEYPADLENDEFAFLCFRLYYLLSYGTWYRGKYTSKKGRNSEEKQKGMEGESWASGLYGSVYKGPGVSEVEWHTWKEEAEKGELGTVIMSDNSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5R8</accession>
    <name>A0ABR3C5R8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616953.1">
        <property type="nucleotide sequence ID" value="XM_066755052.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987341"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046106146" description="Right handed beta helix domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Right handed beta helix" evidence="4">
        <location>
            <begin position="136"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="606" mass="66282" checksum="F23F1D3E6DF26F0D" modified="2025-10-08" version="1">MLIPLIPLLLHVASTVAATTTKCLVSGNEDSINNALALGGEGTTVTLCPGSVHRLNSSIIFTAPSQTLTTLGNPKDRNRAMLVVDGEDVASAIKADCKQCSHAMIRSLVIDGNRPQLLRIPKGDALIELGNAESQTVRDCKLYEPRGWSALHFREGDTKQCRYGHIVDNEIGPCGEEWDDAYDGMDEIKPPWGNPRADGISLACKDSVVERNIVYDATDGAIVLFGSAGSTVKNNHIYARTRVILGGINLVDYEPWDGDYTNVKVHHNHLYALGRYFKVGIVVGPASWSDDTESIVHSASVTDNEFSGGYWGYGIVVASANDFEVLRNKVIWDGEQGVAKFSGVPGSRCPKAPENGKPTAFLINRGSAKGTFQDDFINGEVQHIICLNPDQDPPYKPWRFRDSPEAIAAKEAENPAANSAFDSRIAEALVSYQMSLLNSMDAITQKVEHLTNPVVDDAPPFLHEHERAEADQRARQEARRKERESGNKDVDMLNVKVEELEKGGRRLKKALDGLKSDFEGLSGRLKKSADENKPIIETIFVSSQNLLLGATSQQNLISRSLDGAYSGPSFANALGGMAGLAVIIVTARRLRKWWIMKQKTKSNKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5S4</accession>
    <name>A0ABR3C5S4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metacaspase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617248.1">
        <property type="nucleotide sequence ID" value="XM_066755347.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987640"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="161"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="457" mass="49814" checksum="D24D718ED77181D6" modified="2025-10-08" version="1">MSWNQYPGGGHHQQNGYRPPPPQWAQQGFPPPPPPNMGYRPPPPQGYYNSPPPPQQYQPPVPHQGGYQQGGYQPHQQSQGNYRTNNGGYAPPTGAPVESNYHHTSAGYTPLNAAPHHNYAPYGTGAPTQPPSQAQHYGPQLQGQNGQSAQPYFQYSQCTGKKKALCIGINYIGSSSALAGCINDAHNVQKFLIERYGYKSEDIVMLTDDARNSRQIPTRANILAAMQWLVQGAQPNDSLFFHYSGHGGQTQDLDGDEDDGYDEVIYPVDFKTAGHITDDDSRHNIMVRPLPAGCRLTAIYDSCHSGTALDLPYIYSTEGVIKEPNLLAEAGQGLLSAGMSYLRGDTGGMLQGIMGIGKKVMNQNSGALEKTRQTKTSPADVISWSGCKDSQTSADTQEAGRATGAMSYAFISALTKYPQQSYVQLLNTIRDELKGKYDQKPQLSASHPMDTNILFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6T9</accession>
    <name>A0ABR3C6T9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100664</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617132.1">
        <property type="nucleotide sequence ID" value="XM_066755231.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987522"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="219"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="5">
        <location>
            <begin position="500"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="65735" checksum="085E35DFC81BF1F6" modified="2025-10-08" version="1">MPPPHLPSPKHLYSHLSKYVVGQERAKRILSVAVYNHYQRIAPLLPSVNEQELSPPKPSRPQPPPIILESPIPYPPTSSISYSSGSHLSASTFKKKDRASYKPLDPASFQWDPSTAGMSPQDPTITHDLLTLRSREGQWARNGYFEPLQPSVPFQTLSGQTTKRQRVISEHDKPLSNEKPPKFSKGKVYAASTESKGNDPETPKHDGIRVVEGESVIIEKSNVLMIGPTGTGKTLMARTLARLLNVPFVTCDATTYTQAGYVGEDVENCVLRLLQAANYDVSKAEVGVIHIDEIDKIAKRGGSDVGGGGRDVGGEGVQQALLRLLEGTSLTLSAKAPAISSSTHNPSVSSFPPVPGGGIGPGNPSNTLKASSRAVSGDPPGWESNNSSNKGPGGKRSVREGLPGYSSNGGGTPAKGDTFIVDTSNILFVLSGAFVGLEQIINRRIGKGSIGFGAPLPQLATNFSNQSSPLKGLSTVDLTTYGLIPEFLGRLPILSTLHPLSIDDMVRILTEPNNALLKQYIKLFGNYGSELCFTDKAVREIAREGLDRGGGARGLRGILEEVLLDAMFEVPGSSVRYCLITEAVVRRNCAAHYFSRGQKVAFLEAVERERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C807</accession>
    <name>A0ABR3C807_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100414</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616886.1">
        <property type="nucleotide sequence ID" value="XM_066754985.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987272"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="736"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="9">
        <location>
            <begin position="87"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="797" mass="88713" checksum="C315E5445631A820" modified="2025-10-08" version="1">MWEVIYYLNLTLYTILLLSISFVAVLIAVVCSLTGRRLNTNYYVARTFYHVAGPILGWKFKVEGEQYLWELSGEHGGGNAGEKGRSMVMVGNHQSFVDILYLGRIFPKHAAIMAKKSLQWIPGLGWFMMMSGTVFINRSNNKSAIASLQQAGEEMKRKRISLWIFPEGTRHNSPEPELLKFKKGAFYLAVQAGVPIVPVVCENYNHLFNGKSHFRRGTLRIKVLPPIPTAGLSTADVPKLIEKTRNAMLQTLQEISTPSPATSQTGSPDPLLGRSGRGREEYYTSGSPVPPEGVSSTVEIGAEEEAEAAVEDAVGREEADNGERHPPVFGQNDRGDETMTTAENVQKSSPKRLAIAMVSDFFFPIIGGVEGHIYSLSVELMRRGHKVIVITHSHPDRLGVHYLAPSLKVYYLPYFPITSSASLPNFLLFLPYFRHIILSENIQLVHGHGALSSLAHEAVLHAPLLGVKAVFTDHSLFGFGDAVGVLTNKLLGAALRCVDEVICVSNTGRENTVLRAQLDPSIVSVIPNALEAEHFKPDPSRADPDWITIVVISRLVHRKGIDLLISSAPQICALFPKVRFIVGGDGPKMVELEQMREKYELQGRVELLGRVNPGDVRDVLTKGQIYLSNSLTEAFGISIIEAASAGLFVVATKVGGVPEILPQDMIEFCRADEDDVIRALTHAIHTIQSLRHSPWSAHIRVRDMYSWSGVASRAEIVYLRAMSRPRREIGERMKRYMELGPVFGVVMCCILAVEHYFFWLLEWWNPRDKIQQVAKFQDVENFEDGGKKEGKQVRIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHH8</accession>
    <name>A0ABR3BHH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106728</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610688.1">
        <property type="nucleotide sequence ID" value="XM_066761148.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993581"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0240180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14299" checksum="9DE680B5913067EA" modified="2025-10-08" version="1">MRPSSLLRATHYRPMIKFLGPRKNIEIPPHKLGPHPCAPKEVQESFQSFLSKLNSSSSSTSSSSSSSSSSAGSASGARLSSLESTFKPTGKKVDYENYWEAPTYLWVQKEVTEREMEAVMSGGATDIRTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIF5</accession>
    <name>A0ABR3BIF5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610859.1">
        <property type="nucleotide sequence ID" value="XM_066761034.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993466"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="450" mass="49689" checksum="F5AECF92D362F1FF" modified="2025-10-08" version="1">MSIVSLFTKLFKRIGKVFEHTSSSPIPPSSCFPSSSTNSHSVSTPTISNSILPLNIKTTLPTLSTIVADVEKMKKDVSVNVVLDLGSNEQVDEKIREKTIQSSRLAEEVNHTSSCLSSRRISHTYNTIEGTNQTFHRVNTPASSPTSSHMDDPFHISPVKVQVVRTFNYLGVTNKLRSLPPIRPDSLYCMDELDKVMKAITTHYLPNKAQSDTSTPTVRLDNTAVDRSSITPEGGLDKDHHTTALGAINPLGREHTRTDSVTSLFSMYGHMSEDELISRDRSVASTLIFFPNETSNNSPNPTTLLQPHTTLHTALSLSYTPWSALDSPTESDDSNNSIPEIIITPENSQDSIDYFSSSPTKNNSKDRRSKDSLDIPIRGYKKKTCQIIVSSSKGDMEYSTAGIVVGRQPQSLPANPSSKLTKLTPLRYAPTCELYSSNSFVMGDRFPRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BII7</accession>
    <name>A0ABR3BII7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611002.1">
        <property type="nucleotide sequence ID" value="XM_066760730.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993152"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="72649" checksum="72012AA895887B24" modified="2025-10-08" version="1">MSPSTSSTGLTSPQRDTNSKDANAIRRTQRAPTSCLQCTKRKIRQGERAAGRARRSKRRYPYIGGAVTGGKSTVYDQSIARTFVSTTESGGTVNDLEKMAAVMLLLEMGRGREGNADTFEFAKLQQPQSWSFPRLFATSSLPTVPSTFLSTRLVTFAVEALGFLHGTIHGPSFLQEHSRFIEEKDTQGLLFMGTAWLGFYFSQLTLALHHLPPLTIDAWGIHDPKSLAQLWFNTSLQLLWSSDFMVFPDIMSLHTICALSCVFYAYGPPVFGSILTTAGVRLAQTLQINQIHDETLCKPAEKADPCRLHGVTTTHIAGGPDMLDREIRRRLWWFLLYRDWLSLPAGFPYIVAAESLQSPDPLNLSDHHLVSHGPVVVPPVWLPTNASFHLARTRIARLTHQFFIAYRSLERHDPKRYDLVLSTDARFASLFEDMPFFNPGSDCQNSSFPEVASWLPFARHLVLSLVAHKRLLLFRDHFAMAFSNSAYGEARDMCVARALEILDILRAYPQPSYLIPEMSSHWAAAANVLALDLVYTPSSRQWSPEDRALRIADVRELLSVLKVNESCDSHTSKIVTQVETLFALDQCLRDGNYDEGASALLAGQSVLLPSEEEQGIFPQFLTYDTSFANIFNELRHDLENEAETNGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIR5</accession>
    <name>A0ABR3BIR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bud site selection protein 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610846.1">
        <property type="nucleotide sequence ID" value="XM_066761021.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993452"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00998">
        <property type="entry name" value="G10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0240347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17328" checksum="8082085880DEE0FF" modified="2025-10-08" version="1">MPKIRTQRTKPPPEGFEDIQDVLEDYEKKMRDAESESHEGKRKVEAVWPIMRLSHARSRYIYDLYYKRELISRELYDWLLKQGYADANLIAKWKKNGYEKLCCVRCIQTRDMNFQGSTCICRVPKAQLKKGTVVECPHCGCRGCASSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIT2</accession>
    <name>A0ABR3BIT2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor TFIIA large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611102.1">
        <property type="nucleotide sequence ID" value="XM_066760830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993256"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="22603" checksum="FEA2214B51031E10" modified="2025-10-08" version="1">MEEEILMHLQQRWEAKLLETRVADFARAGSSSKSPSPTLESKPEPSSPPAGPSNSQSADMFPFPRQGQVQGSSAAMPGAPGVGAVGTNGFVNGGVQVPGGQQGEIRVKMDPDELMRLRGGAAEDGHKPEPNAAGLLPGDDVIDSDLDDSDDELRGDVDGGEDDNDVDIVFCVYDKVQRVKNKWKTVFKDGMIHLNGKDYLFAKCNGEFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIX8</accession>
    <name>A0ABR3BIX8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106441</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611142.1">
        <property type="nucleotide sequence ID" value="XM_066760870.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993296"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="740" mass="81815" checksum="BE3ECC490203DDA3" modified="2025-10-08" version="1">MDADNDATSPLQSAPAGPSTAASQKIPIKVSCLQCRAAKRKCNTLGAHTTCRRCQGHNLPCEYTPPNRRGRKKKAPSESHSKLENSIHSLSVSGPPSRASVGPGEAFSAGDNDASGFCGSITGPSQQFPTNVQLQRYNTAINNEASIRTLNGSAESSPLDRQSAVHSCSSTDRLGSMPVEGTKGRFDIHYSHVIPGEKNSLPSNATNKDVLAQQQELLIQKLRPECPDPVTAGFLREQDIVEIFDFYFRHLNAAVAILDPVLHTPKYCQRHSPLLFTAVVTVTVRVIRPNTYPQCLLLANKLVGQAVEFGLCSIEVVQALCLLTHWKKPDDETSYVRMGYAIRMALLLQLNTKAPRPLPQDERHAREILSRERAWYNLVLGDYHLSIHHSLPKMITDDVEDPADWVAEHSHLPTPGESSFGPFITFSRMISLYADSLGAMSGDPSNMRMLSWMDLEWTRWRGRWLKDNERYGFVQFQISAIHICDALFRFHICEYRLLFIARYESQGQVLDTSEPSPLSMAFTECADAAVGIGGVVLNDFVPYGYLAYCLNLTWSALASSAIWLTKNIEPMSGADRARVIRLLSDLQFAMEEASCSSDDMAAYTHRLLKHLLSGISPEWQLASFMTKPYHHPLNQTSGQAHHQSIPNTSVFTQNTSNTASSGPLNWAPSSAQELIQSYLWSQQPQNYFPAPATNTAPAQSSVGGQPDVSQLSGVMPGEFQNLFPANDDDLWKHLFPSGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJB5</accession>
    <name>A0ABR3BJB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611272.1">
        <property type="nucleotide sequence ID" value="XM_066760511.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992919"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF203">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="717"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="970"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="473"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1506"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1578"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1510"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1523"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1586"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1602"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1615"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1642"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1662"/>
            <end position="1671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0241890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1689" mass="185610" checksum="18AE65F4E768D6CC" modified="2025-10-08" version="1">MTRKLKLSASPSALELLSIRPALVTLSPLPASPSSPLPPVTLRHDRTALALSLPLVLMSGAHQKDYSENNRDLELPSKPATSSISIPPTQSAHTLPPRPNFALPPRPSTVPCPPRSARPLRSSLRSPSPPRVSWRSRITDTGARISRSRSPSPRRYRSRSPERYRSSKHTKYRSPSPRYQRRSPSLRARSPFAVRRPSIRRSPSSRPRSRSPPREKLREKSKGSLLSRIVGQHPSKTDHHIAPPATSLERSLSPTATNEQSRKLPAVSVPVPTGPRTSQIPTGPRTDRIPIGPESLQNQSLNQGRPTKLIPTGPRNSISAPVPPSISNTKAVAASENQNYKYTLEEMGNPRKRGGGSKPPPTGKKSLSPPIHDLVYISETYGKGITLKSQWAENPKSPVANFILKGKSGDINGCYSYTEGIVDGKKVHRVTMTPVNGIYGIGDSTNKKEAEKLAALSSLLQLISIGYLEKGKASNGPSEPNNFTKPSTSTQAVSQIDPEDTGETATLSDGKTKIDYDRARQFMEYYCHRYRFRKPDVEYTQTTVKDPRNKKKTKMVWEGVIIVGNRRIGMGSGMNKKKAAIQCYLDVTQYLESCDPDLWQDFIEHTKKDKSLNIGLAPHLVFTMSEALIDDVQGTCIDIRHSNLYQNAPPSGSAGNEVQAPPTWHGGAQYIPTENEIYYKSQELQARLAAYESDPRMARMRRTRASLPVYSRANEMLRTIRDNDVTIIMAATGSGKTTQVPQLLFDEMIKQGSGGGCNIVCTQPRRLAAMSVAERIAEERGQVIGQEVGYQVRFDAQLPEANGSITFCTTGIFLKRMQSALGENANEVAVQRMDQVSHVVVDEVHERDIDTDLLLVVLKRLLQDRKRRGVPIKVVLMSATIDPTLFQSYFTDAGGAHAPVAEIPGRTFPVEKSFLDKIVPQLQNIPAQRGGWVFNEKNVKEYLSRELSSNASNFGPGTGIELEIPYPLVALTIAFVLSRSEDGHVLVFLPGWEEIKKVADILLTGRYPLLGMDFRDPRRFSIHYLHSTIPAAEQKEVFRTPPPGVRRIILATNIAETSITIPDVVYVVDTGRVKEKRYDPERHMSSLVSAWVGSSNLNQRAGRAGRHREGEYYGLVSQRRLDSLEAHQMVEMKRSDLSNVVMHVKALNLGEVQEVLAATIEPPEPSRIIAAMEVLRMLGALDARQNLTSLGRVLLQLPVDANVGKLCLYGAFFRCLDAALTLAAVLTNRDPFLAPPAQKAKADSIKDRFSPKAFRSDPLAIVAAYNQWLPYEESGDFYSATKFCDNNFLSKPTLLQIKQVKQSLLQSLDKAGVIAVSAGGMVDRIGRYGSIPPALNENNDSLPMLAALIATATAPNFAIRTSEKTCRTWQDKVVVIHNSSVNSRRREVNGPEESSASFNPAEKRLYAFAEKSRNVPVGGNPNSAPTNLRTVTRLDPMTYMLFGAYELVVTARGLECDGWLPVTGNTHALDDVQRLKAALDVCMLRVFEGLGKSLVMGRDQRWMNGAGGVEVHEGTSRIKEGGGEEENESDDEDYDRPREKSDQASSRYAGPLTVEEINELEMLTTDIVTILNKYADEREGGGVDTVPQTRVNTRPSSPQGRAAQWAADVAAAASYGGGGSAQWGDASGGASFGGGGWGSDLHSARKQGDGGKRFDTWDDGDGWGSHQGGQGDQDDSGWAVPKYKPPQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJH7</accession>
    <name>A0ABR3BJH7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_106125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611333.1">
        <property type="nucleotide sequence ID" value="XM_066760572.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992980"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="937"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1107"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0241951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1200" mass="132996" checksum="2300A022A817CBBC" modified="2025-10-08" version="1">MQEEPKKKRRQNVACDACKHRRVKCDLAPLLQSIHAESTDRLDISIAGGTSTSSTSGNSPSLVDISLADLVRQNPEVYCTNCKSKGLKCTTDQILNPSKPKKGGRRIDEARERFGGHGETSGGDTEPVAGPSDVPASGVSGTAQVWSELNPWIAEDFIVLTPSQPSSFVQPPSDVNDSLPPEILELNRATPVPHTTSLLGLGSESWMDFGPSILPAESVPINTVDPNSMAIPPFLPTSVASNTPSINLSHPTETLLDDRNGSTPVWWPFSDLPRETMEHVEHAGKTSVATSPIPPPNQFENGQFFGNTSLDHTPASISRLVNSYTEPFAESLSSGQLSDYQQLASNFFPFPRHDSAQTKKRDREEISSPGSAPGNKVLVRRKDPWQLYTKEEDLRMVRWGKKEAVQEKLADRALGIELSRHLVKTFFQAVHFSYPAILPESFYLEWMRAGQRSDRMTPAQEVLCSAIEAWGARYSDSPIVLGLSPEKAKMAPKVIQANGTFMPGAQARAYWGRARLAACKALLERTRQLIDTNGILRKPSITGVQALTLYMQLINMTDDTVDGPAQYMEGLMIHRTITQQMQILGLMWDSDQPIVTDSDELPMSLTQLRMKQRQVAHHFCVRCEHYAFWAAASGNEPTVPKTDMDAAGNWLRSVTDLLSKNSFKALSFYLTCYYRVTLIGRDVATSLSIPSKKKGAVDVVKFCNHVQRIWKDIDAFDTDMNPQVAHLMSACPRDDILAFSPLSYFSNLRLASPFLLLIIHQLICEQLEFCKTLSSAYITASHDHLDYNKASSDASRDEVNSGWTKAQSHEQMLQDLSLQSIDFMLKTCRAQVGMFKALMPTGTIQTSMLLLRELLAAAQFLAEVPTNEQGYPDDTPGGYDWTWEKKQEEVNCCVDALYQVGWAWADVASALDNIMVTMERLTPGPAELAAYKERVASRPPSQTPKMTEIASKREKEKRDDEAALKAVLSHWPPLSVPELIENAIETGGLDLLNDQSVLRLNFFPNSLVDEIESLGSGRSPHGASSTFASPEEETPKSVSRAQSGFGQDRERKSGCTHLSSADPSTAKALDDIFPHMCYREISDLDSNGQRLIYEEACFVRTWLSNGKPEDEKCNGQSSKPTRESNTREVGYQGMEPRTPLMGIMTPFNRVESKANSVIPEISIGGQTENSSEESFTLKDADEAQDQLQKFFDEWGKDMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJK7</accession>
    <name>A0ABR3BJK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dehydrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611359.1">
        <property type="nucleotide sequence ID" value="XM_066760598.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993006"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0241977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="35564" checksum="B6AB6F9E178BBB76" modified="2025-10-08" version="1">MVDLGAPIGSHHQSNIPASEQTGFNSGVGGEHASAGIPKGTPIADQFMGGHSSGATRATGTTGGVESKLDNALDHYSSSGSADTTGTGHHNSGLRSGAATGAATGAGVGAGAGTLVFSGQAVSGQYSGGGTKDALSGQTGHTTGAGVGYYGENLPIPAGAGTHPSAALHSSTTGSATRVEKDAVGGAYVGGPAQDALTGKSGATTVGEGVGPYGENLPHPGTTTGTGVGPSGGAGGHYGKGAAAAAGVGAIGGAGLAGTAGQHGSALGAGEGGISGTPLGPGAGDGSTGAGITSGVAGVGAGAGAAGAGSELGAGGAGAGKHGRAQPDEDRGAPLSDPKELDTGGPHSLVYQESTGKYVHRHELEGELGSAEAAVKNASERRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJT4</accession>
    <name>A0ABR3BJT4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611432.1">
        <property type="nucleotide sequence ID" value="XM_066760671.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993093"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="133" mass="14715" checksum="872B6DB579F7A9B6" modified="2025-10-08" version="1">MSFYPQTEGRHTSVRRTDFKYIHPTSTTQAPSVCNDPSCRDPHCGLGPISRVSTMPTPSGCRSNEPCSDSRCNDPRCFAATTRRSTELLPPTRQGGSAVYPYFPPPINSGGWEDNEHFSKNGGYEFPNTYPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK67</accession>
    <name>A0ABR3BK67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105766</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611519.1">
        <property type="nucleotide sequence ID" value="XM_066760215.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992621"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="83"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0242137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28945" checksum="4702C1827CBC78E3" modified="2025-10-08" version="1">MWRQSISRVYFDHHSKISAITMLPIQEDVSVGTEPLPIPISHLSTPIHNFTYITDSQLGHGTPLSLTHPLLPDSAYHKQPSSSPISSTKSDNSSDVEDVWTCTCASQHESEKELSLCTAKCGDLCDCVAQFDSASDKKRYGEGQGNYILSLRLPDQTIHIDPRWKGNVGRFLNHSCGANCVVHYVKWGGGQGWPRAAIFTNKNIHPEEELTFDYANASGDPQRALELIQETIEEDTKGKTRCHCRAEQCRGWMPFDETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKA7</accession>
    <name>A0ABR3BKA7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611004.1">
        <property type="nucleotide sequence ID" value="XM_066760732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993154"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="397" mass="45363" checksum="A089522B09915BC5" modified="2025-10-08" version="1">MMMQGSVDMTDAETFAKHCVAFYFTTSIPPQESTAYIIYALSALPPAQHTVFAGIQASIRSLAHIYHFQIRKVLFNKLIHETSISDFRPTFSETPSQNVFNVMERRARLSMFISTWCSKEKSELFPFFHGLYGVLYIQSQSSKIGVNDGEYRVVWEIDDAVFQESGGSEFMYDAIFILKNVLKFDIHTTYNDVEDQDIYRPIIIRWLSRITHPSQPLAPFSHLPDVNDQARAPSQPMNSLCNHSSPSTDNQLLFEDPHALEMINSSYQHVFIDSAGIYTSNDGELAVLETKLNKPCFSGWEFPSAIGNEEILGLMSLFPRVISKMPKPHFVQLDPEGIVDQQYHGHTPNISYQAASQKVAIFGTGRVWVGLNKRTAGWKGSWWFRFKLWWCWLFGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKF0</accession>
    <name>A0ABR3BKF0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611657.1">
        <property type="nucleotide sequence ID" value="XM_066760353.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992759"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="74"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="283" mass="29900" checksum="033D57029521DF26" modified="2025-10-08" version="1">MQDKPLSAERITEERAFIKRYTESLADYTVQYPADFSAPLHERPRKVPAIAIPVPNPPSADAMDVDAPSQDTVISLTVKSLKPSLTIPVTAQLTDTVSDLKSIISESSASAPAPDAQRLLFKGKALTDTKLLKEYALESGATVHLIIKPPSAAPPSAPTPSVSTSDATIPPPSSVAPHPPALTITTSANESSQAGTSMPLTLADQVAPPLGPQPEVSSATFHRTISDPTFWQKIHALCVSEFNNEQEANSAWETFLISMKGGLSAGEAAKIRDVVGVWGMGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKK7</accession>
    <name>A0ABR3BKK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerol-1-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611335.1">
        <property type="nucleotide sequence ID" value="XM_066760574.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992982"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0241953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25408" checksum="87886A52E423AB6D" modified="2025-10-08" version="1">MRPTTIKARGILFDLDGTLISSTTICESVWHKWAEVYPVDLTEVFKSSHGIRTRELLRHWLNITDPIELEAATEKFETDILKEAQRLASTGKGGITLLPGVEKLLLALNTATKDAIKWAIVTSATNAYATNAITTFSLPKTSHLITADGVSQGKPHPEPYIKGAAALGLKPTDCIVFEDAPSGVKAGVASGARVIAVCTSHKRSALEGLGAHFIVEDLSDINFDTEGDEVTIIFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKU9</accession>
    <name>A0ABR3BKU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611611.1">
        <property type="nucleotide sequence ID" value="XM_066760307.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992713"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0242229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="132" mass="14516" checksum="D5916EC56A78A5B2" modified="2025-10-08" version="1">MTFKRRGGGRNKKGRGHVKFVRCSNCSRCVPKDKAIKRFTVKNMVEAAAVRDLSEASVYAEYALPKLYIRLAYCVSCAIHAKIVRVRSAKPGAINSRKNRNPPPRAIFKDGKRINPAVAAAMAAKTAQAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKW4</accession>
    <name>A0ABR3BKW4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611626.1">
        <property type="nucleotide sequence ID" value="XM_066760322.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992728"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF1">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="854"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="909"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="958"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="997"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="152"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="589"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="878"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="1016"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0242244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1252" mass="140291" checksum="4734CB09F06C8760" modified="2025-10-08" version="1">MPFQETKTPQPPAIKFSSSNVPHSERPIPFPSTPRSPLRSTSSSSGEQGESNGTPASRKHKGSHNHVRINDDPEITINNGDEGPSGNGHRKRASFAFTVDDDAGRHDAENKGSGDDDQINEKTRSEKFKILAGLRLKKILGHRWFCWIGPKLTWGKLKPVIRCAIAAWLGLVLLVIVPVETAMGNGAFFLLIVSFMLPPSDPVVQTLEKYLYLFLFTALSWVWVIIAVLIAGATRGPPDPNRVAAAEAKWAYLKDVNPTKYQQRIIFDGTYLQAKPAVVCSIFLSAGTGALLCWKMKTQPSPATFPFVLACILMDVSLTTVVFFPYNFYTSGLLFFLPMAIQVGIGTLCSFLIFPESVGHSFQSKFPGILTPLASAMKSIEALFGEAEKPDNGQEENTDDLLSVRNSEYEPKFYADKLDDWAERSKKIRAQLLQSLAGLPPLRAQQRYLAVDVSYSRLSGEDLRNLFDRLAIVQARSGGMAFFFDVIVTNAKHSHLDSSAWSVHQVSQSRPGSRAASIRHEFLDERRGSVDDSFHADETVTPPPEVDDHAESPHHDRGLYFGSRKFNISGILRRSNSPLGFTATQKGSHLSLLDHLRKSQQPVGVYESTRYMDIERNFAVDTEHVLEQLDILARGSAPVIRACEAALSEATDWILNVNRDRKIFPWPSQHRKARKEKGRDEKIVATTRLEEVTGHLQSALDDFCVTRLEIIQPYKHLFDPTHPEDEGHRGKMHFRSLFQNFVAQYHVIEFAEALLKLLRLMEELDKSRQKRRLWYPHLTTMVDHFRHSHKDEHLTGGDDGHENEVAFEQEEEEDFLGEAKKRNPEYKPFDSPLLNLTAKCSGALDILSSRSFMYALKAAVLGALTTLPNFIASSASFYYYNRGVWCTIMAQLTLAVYSGDTASAWLGRVVASFWGCLIGMVLWYIGSGSGQGNPYGIAAVCAVAFPLASFFRIHFPGPLLTAVMTPVTMGLVIGYSYYNGTIGPLTNAEWGWDVAWRRYVCVFIGISAAWAFSYVPPVYSAKRAIRYSYARTIGVAGSIFCEVLSHANDHHYHLKENDAIRHNLITWKSKLNKLGKRHINATREFSLRGQWPEERYKALFETLQDVFSLLSQLNHVLTQLERPWRKALLDRTRLSDPIFLGDVMVVLSMCSTALRAGTPLPQITPSPLVARFRMGKTKGLDLPQDPTDQSGELPSLVTVDVLESDNYMRYALGITTTFSLISRLDRIVVICKTLLGENYHISGLHLEQTTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL75</accession>
    <name>A0ABR3BL75_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine-specific methyltransferase SAM-dependent domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611917.1">
        <property type="nucleotide sequence ID" value="XM_066759971.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992371"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="4">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="4">
        <location>
            <begin position="161"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="269" mass="29618" checksum="38E5CEEF885DFAF1" modified="2025-10-08" version="1">MTSTIFTLPPTRRSSSESPDSDTSPWSLRSEIESALKGTDEPTIPGSGEEDKNWAFKRSVPTVVLYDEIGLRLYDKITAEAPEYYLFNDELNLLKVHGKEIAQCMGFSRTNKNDQGSPDGTEYPPEKRWKPARWGDEAVGKWNEGVNGEEGLGGGWQRGWDVVELGAGALRKTAHLLTALASSLPDPSSNSSTLPPPITYHPLDLSYPELNRVLGEMHEAIGDKIEGKVACVGLHGDYEAGLQFIRDGKLAQMRKSLNDKPENFAEELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLV2</accession>
    <name>A0ABR3BLV2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612142.1">
        <property type="nucleotide sequence ID" value="XM_066759495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991891"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0243775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="360" mass="39778" checksum="E938DCBD25488E18" modified="2025-10-08" version="1">MSDNAAFKFGSFDYICQHAALVVCPMLGDQQGIAPTCYSRNVQLGSQIIFQPSTCILHIAALIMAAIMVLHVRSKYTAVGRKEIMLFFYMYMWVELFAIFLDSSIIPTANKVYPWFAAIYAGSVGALYWCLLINGFVGFQFHEDGTPMSLWFLRISSLVVGAVCFGIAAATFKGTSSSMSPTNTVGLFITYLVFPCVCVLIYFISQMLLVVRTLDDRWVIGDLLFMAGFYIAGVLLLIAFSVTICDSVKHYVDGVFFSTLAFLFAVMMVYKYWDSITKEDLEFSVGSKQAVWDVKDPLLATGMDYYEDDTQSAYHGAGGSLVGGYNGNQYYSNQPGYAQSAYGQQGYGQYGAGGYGQGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLY7</accession>
    <name>A0ABR3BLY7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612177.1">
        <property type="nucleotide sequence ID" value="XM_066759530.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991928"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="67169" checksum="B6D8A59048AAE448" modified="2025-10-08" version="1">MPENHELDSYGIQASAETSSSSRPLLSRDPSPPSSPSRHGRPHSTAPYGYPSIHSTYRRLWKPILILSIPFLLVFIYSLVHPHVKGLPPLPKISITSGNAVGQPYYEEKIVQECICGATDEGKRLCSLYHEETLRSSRLIEGTGARIRQVLQKARNGEKIKVSVLGGSVSACHGVHPSNKFPQGDPAGPGCYTSLLMGWFKKTFPDADHEFMNGAIGGMDSSYYAFCGTHHIAANSDLIILEFDVNDQNDVLYETFFDQLLRALSEFQSEPAVLILGAWAPQVAQDQGYGDPQVVHSPIALYYDVPYLSMKRVLFNHYLRYPHSTAKTFFQPDLLHPNARGHRVLSDLLIAYLDSQLCMLSKFGLPIAHPLQDTISTTRPFTDLIDVPFPLDTLHLVDPATPPEGWEETFNTEPLEALSDEKRFFAVPPTPYSVPPVGMFTPLRDVVNPTSDDPITGEHITAIAQPHLFCADANDKKNPMKPTVADGWEPFVWNGEKHYWVSHKSGSRIRVEIKVNAGKVAVYYFRSQHYDLGDAKCWVDDNEKGAVTLSGYWTKQYNVAVAAYIDEKVTPGDHYVVCEVLDTTSHPTNPNAHHFRLTAVMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM65</accession>
    <name>A0ABR3BM65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612251.1">
        <property type="nucleotide sequence ID" value="XM_066759604.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992003"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="725" mass="79987" checksum="F90FDAB794D82CD4" modified="2025-10-08" version="1">MGRIYPRPGQPHTSSSPFSMSPQHERPPTRAHTATSSSSFPVLATPPSFHLDSLSLIDRGLTRKLEHPLDPLGQNSSVKRSLSALPFSPLGKSHGFSSPIATHALEDYHFPSNYTPAGTSQRIPKNFIPQTHSPLISPDALLQVKRPKKKTKMDMNMAQTGSLAALPGIQTPLASYVAQMIVWLWYGQFQQQQPPSPISPSNSSILDPFDPTYHPQRISQLMVQPSSVFSEFVARLLQVTMVSHSVTLVAVLYVYRLKMRNVFYSTPGSENRPFVAALMLANKYLDDNTYTNATWSELAGIPLTEINRMESEFLVGLNYELGVKIDEYERWKMLLDEFMLSRGPSSAATTAKHRWNSGQTPFGAHPVCTPTFSYGTRAKSASPPRRLRPDYPAAPSSRKRSAADAFFLDSIPPPLHHDYLSVPQPSQSYSQDRPLRPALVTQTSNSSLARSASLNRQLARLPSNFGGRRGSTGHVYPASTLKEPASQYQQPSPSTYGQLVQAAIQTEWDSSRALLAPYDDSLSQPQLVPPEHLMFYSLAAEPQAGTAGHPRKSILRYQAPIAGHPSSHPPHPSYPPYNPQASQAPYSYQAPPPEFSPQDVGVFDGQVHPPASYYPAGHASSHSETQGMYTPDPYTVAPGWPSMQVDPQPAQFANAGPPGYAYNPYVPTPARWEGFTPATHGEVMYPGWARTPDGVLYYHPEPQIGGPPMWTSRSEWSSPISRFHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMJ3</accession>
    <name>A0ABR3BMJ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612379.1">
        <property type="nucleotide sequence ID" value="XM_066759732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992131"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0244012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="97" mass="10916" checksum="B03B267543E707CA" modified="2025-10-08" version="1">MYAHSLPLLGPTLLRPHFLAPARPLEDLGFGPSPLFGWGSVMPRGHSYGQPKYLRYQKPDHRRFCYSVGKAEVPYASLPGGPLWGYPAHMAEQLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMN2</accession>
    <name>A0ABR3BMN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611223.1">
        <property type="nucleotide sequence ID" value="XM_066760462.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992868"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0241841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="38163" checksum="3360BA8C1A873C9D" modified="2025-10-08" version="1">MSFVDEIDWDQFLVDTDLGDKNTNVSPATSTATLSSDQSAALDPQPTNFGFGMDAFNSSPSTGITHRLENMLPVVSPEAAHDQLTTSFGLFNGFDTGAFCQSVTTPAASDSSTELFAAISQLVGSSTTSSPSAVEPLQLSLPPTPDSTTDYHPNSNKRKASDASDVGAPAPKRRGRPPGTGKPKASQPMERRQSKTSSFSSVSPSSFNDTLPADDSDLETASPPVKVTATGKPSTDRPKSVVPAKFLKDGTAQAILGMTIPEILSFPTYEELLKKVSLELLPGAREFGEKIADNRDKAKDAAKKSRDERRAKIERAEYFEKKCEQLQEQVASMSSFLMTLVELNVLKKDQIQAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMU1</accession>
    <name>A0ABR3BMU1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612461.1">
        <property type="nucleotide sequence ID" value="XM_066758974.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991356"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0245377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="94" mass="10758" checksum="A699D20FB538E7FC" modified="2025-10-08" version="1">MTRSSTARMFLAQAFENVQSALTAAGGKGWDQVFRVNSYHVPLNNEALEAMVRNFRKWMPNHQPLWTCVGVTRLGEDDMRVEIEVQAYDPVKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN58</accession>
    <name>A0ABR3BN58_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA repair protein Rad8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105119</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612223.1">
        <property type="nucleotide sequence ID" value="XM_066759576.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991975"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF26">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chromo" evidence="10">
        <location>
            <begin position="86"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="2168"/>
            <end position="2331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1658"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2317"/>
            <end position="2393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1601"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1661"/>
            <end position="1685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0243856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2393" mass="268431" checksum="682592E3FBCEC4B0" modified="2025-10-08" version="1">MVAAPTFDGGPSEDSRRTSLRRATSSTDVSYNIDTKFDIDMDGIEDRAVNGKNTRNIPRCSSQSQKRKRTSLSRDMESEEDGDDWYEIDYIADSRVIKRNGRQILQYLIHWDGYAVHERTWEDEDGIGGDDCSLVQEFYQKNPRKPRLLPPSVRKEVKSARKVEVVITTRRIDGKNSRATYSTDQPSPHRIRRTSLQSSNVDEEDPIRCPVLPAASKPAEESSSRKMHPNKKRKTSSDDESDFAFEESEWDEDEDDDVEFKSDEDNEQEGSVEEPESDDEVIKPARKARASLPKAKSRPKPADLNSFVTGVRPLSQGLDIKAAVRNVSEDLPPISDIEAMFDHLVSRIPDIVKLVRRLNGRKLRVATMCSGTESPLLALNMIAKAIKAQHGLTLAFDHVFSCEIEPFKQAYIERNFAPPILFRDVTELGKKRAHTAYGSMAEVPGDVDILIAGTSCVDYSNLNNVQQDIDANGESGRTFRGMLQWVKKHQPSIVILENVCNAPWDRVVEYFGQIDYDAQHIRLDTKEFYIPHTRTRVYLFATPSSPESQDLPRKWAQTVKELRRPWSSPFEAFLLHTDDPNIHRARVELASARAQADGTSRKTTDWNRCESRHQRARQDEALGLLRPLTSWQEAGVCKGLDWTWNDWLLAQTERVVDLLEISTLRMAKDGIDSGFKACIWNVSQNVDRQTGSSKTALAPCLTPNMIPWVTIRGGPVTGREALALQGIPVRELLLTSESEDQLADLAGNAMTTTVVGSAMIAALKVACRKISKGTNPEKEAALVLEKEAIDDKQVANRIIGEESLEYHDLDLAKVTKSNLFEILNLAFRSSRHCQCEGQSDTAPNILECQECGYRACKLCGGRPEHVYAPCSSQRVEPAEFEKIFKGLLPMRVRIAGITGQCLNAIRKEAEKSNKGSVSDGDWQLWTTALLEGIHDAEFRFRYLKRQSTWTAVYEARGAMLSLVLHNRIPEWRLTIKTPASEPNNSRLRALLLHPVARLQIDIGGQDVLCGPWELCIPFKKTIDIEITGKGELLPSWEASLGLQGPFANTTRWSELEISLQADDENTLDRKLSGTYQLLPRCGQAMSSLHKKRSNPSGDGLPQLYFFLDPTRCGESREDRYVFSTSIERLDYGTERPVIARLDPKWRESNERQRKVKLDVSGAWVRCPEAHLTAVGGNDIAVVANDIGANEIHRDRATYAIPSSASAISASLAIDGCSHAIALLSCHVPLDPAHSESMWRRGAWAEIDLSHQGITTFANLAWITERLPPLDALRNWTRIACDVSENVCERCAPKPPKIHWIKKEGKANKKGNKTKSTIIAFEDKFEAGQYEHALKHRPSPFVVQLRLDRDIGSFRIGLNIVSLAHRALSRLAATTSKDKISLSWRLTPGHVAEIPQPRRIFVLPSNKQDPENSQPVGFKLPLRKEQLRSLWWMLEQEKAAGKTHTFVEEEISESLLPAVGWRAEGKAERPVMVRGGVIADQVGYGKTIISIALVAQTMFFPAPEPAPPGLIDLKATLIVVPGHLSKQWPNEITRFTGNMFKVIVIQAMKDLQGKTIAELGKADIIVMASEIFESDVYWSRLEYLSAQPREWLHDTQGGRFFCDRLDAAMKTLTSQTQILKEEGSNAAMKAMEDKKKSLTENARAKKEVHTAVNFGKRMKGQAYRDKHDSGSKTKPITKDELERWEASEDEDDDEENKTYISIPKFHSSTGSESVSSAPVKKDYTLLLNPVLHMFRFRRVIADEFTYLQKKSLAAVLRLSSSYRWILSGTPPVNDFAAIRSIATFMGIHLGVEDDGEGDVQYQKARAKEQTQAEKFHAFREIHSRAWHNRRDELAQEFLNVFVRQNIAEIEDIPTIEHIHTFKLPASEGAIYLELEHHLQALEMQARKETKFKNVTQGDRNARLEEALSDSKTAEEALLKRCCHFTLDLSDKTRDAKSAQEACDHITSARARQLLACQEDLSRSVNHAIALHGWIKKKGGFSKGDNERQPFAEWIAFSSNVSKHQGDIEAARILLKVMEKCGVKNGSIPPSPSDVQSQSVANGAKMDDVKWQLREQTHLLRKLVKELVARVRSLRFFEVVRKIQKGRSDARIVLESSECGHKPSTNPDIEMAILSCCGHVACHECMRKAAASQRCVKSGECHAAVRPTNIVKISSLGVEGELSSGRYGAKLEHLVNLIHSIPKDDRILVFLQWEDLAGKVSEALSAGKIPHVTLSGSAKSRANTLDRFQSTNAATARVLLLKMNDASAAGSNLTTANHAIFLGPLFTNSLFNYRAVETQAIGRVRRYGQQKKVHIHRLLALDTIDMTIFNTRRAELREKTDWEETPQEEYKGGGSSISIADEKRKPTSTAKSNPLKRDFSLALTPSLNNKKRPIQTRDGGHVSDDDEHSELSDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN71</accession>
    <name>A0ABR3BN71_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polyadenylate-binding protein</fullName>
            <shortName evidence="6">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612597.1">
        <property type="nucleotide sequence ID" value="XM_066759110.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991501"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="47"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="135"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="228"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="331"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="9">
        <location>
            <begin position="570"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="645"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="674" mass="72649" checksum="6BC0A2C478CAFBA1" modified="2025-10-08" version="1">MSAETATSPAPVAETPAAPASTQTTPAEGAPAPAPAAAAPGGNTVSASLYVGELDPSVTEAMLFEIFNMIGPVASIRVCRDAVTRRSLGYAYVNYLNAADGERALEHLNYSLIKGQSCRIMWSQRDPALRKTGQGNIFIKNLDQSIDNKALHDTFAAFGDILSCKVGTDENGKSRGFAFVHYSTGEAADAAIKAVNGMLLNDKKVYVGHHVGKKERLSKVEELRAQFTNVYIKNVDLEVTDAEFEDLVKPFGPTVSVALSRDEQGVSKGFGFVNYENHESAKKAVDELNEKEINGKKLYAGRAQTKSEREAELKKSHEEKRIENEAKSAGVNLYIKNLDDEWDDDRLRAEFEAFGTITSSKVMRDDGGVSRGFGFVCYSSPDEATKAVSEMNGKMIGTKPLYVALAQRKDVRRQALESQIAQRAQQRMQYGAGFPGMQGYMGQPMYGYPPMPGYGQPMPGMPPVRGPMMGYPGAPQNMMQSRPRFNPNGQPLPGGVPAYGMPPQVPYPGAPGYPVRPGGARIPAAPNANGPRNGGPSPVGAPQGLPAGSIPRGGQMPARPHEQAAPAPQAGRLDAQSLARAAPAEQKQMLGEALYPLIHETQPELAGKITGMLLEMDNAELLHLVESQPALQEKVDEALRVLAEWGKDEKPAAADGAEEPKKEDEETKEEEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNP5</accession>
    <name>A0ABR3BNP5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612388.1">
        <property type="nucleotide sequence ID" value="XM_066759741.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992140"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0244021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9118" checksum="5AD407CD03292566" modified="2025-10-08" version="1">MSYPPTTTYRNPTQPSIDAPVVAKQPISLRVMDIRNAGSKEPTQEQQQDEEVMRLRGGCPGRFCGLPILPCACDICIIPIPCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP75</accession>
    <name>A0ABR3BP75_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0246996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612957.1">
        <property type="nucleotide sequence ID" value="XM_066758509.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990884"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0246996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="73" mass="8319" checksum="F7F70147B9FA0B08" modified="2025-10-08" version="1">MEEPFPGHAKIAYPSEEFQGSVSTPCHDHLLNGASQSTCHKQRYRTEGDLARKKQLIRQMMRLRGDTLDNHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPG7</accession>
    <name>A0ABR3BPG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613047.1">
        <property type="nucleotide sequence ID" value="XM_066758599.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990977"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="38784" checksum="123EDFCF2BEDB452" modified="2025-10-08" version="1">MSPTPNMPINRNLRPAGAVGSTTPTALPWRSLVQAARAGRSLSTLRTAPQLPATLPSRAVAGGGFEEGRRRALPDDDIVGQPSENAREPLTSYLHQHFSQISYIDHPATQSFRPHSHVPTSNLITPPSSLTQSVEIPRARVASSSRPPMSLPLTPSSPSSVSGQHDSPERTSVAGVPDHDEYPNSVTSLIASIFPQHAPTVSLLSHTLEILTPPSHILYGFIVDYPPPSSSGRTVFVYLPPGHGTANQRPEALSPNFSQILRPHDPMFSNSPPRDSSPVSNTAYALDIRESLTALLDLAAEALEASHCVLVLNRSESEQEALGEMLHSLMYVGGQVIKPGGLEGAWEWDPMKWILVGMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPK8</accession>
    <name>A0ABR3BPK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily MFS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612790.1">
        <property type="nucleotide sequence ID" value="XM_066759303.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991697"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF17">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="754"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="486"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0245706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="850" mass="89953" checksum="15BB0E778006EB23" modified="2025-10-08" version="1">MTATPPGRIALPPKPTVTDILGGPSALASDTPSPQIHQSSLAANGHSKGTLPHGKARRRSARLSFSSYGRGRTASSRGPAGGIVDDLLDDEDFGPKLPTLVPGIRAAYATPLPVLPMIVMCIAMLSELLAANLCTPFILKQVEGFFLSSGREKNSATEAAVGLWTGNLVSVFFITQFFTSLLWSSIADRHGRRAVLVASLAGSAIALVIFGTSESLPEAICVRLIQGIFGGAVGVFRGSIRDLTDDTNAARAYAMLGFSWGFGGVIGPIIGGVFESPKENFPGTVLAKISLFQSFPYMLPTIIGATVLAFGAVLSCLLSWDGGVRGGSRIALAIEKNEPLAGVSPVPGSHASPAPSSRTAIRVPSISLRRGILSPGQEEEDAAHGAGYPELSRSVGGRRDSRASLGTAYGYGGIRSKHPTLAARAAVEAARRASAAVGRPDESEEEEGEMGNRALKVAQKLLLANEENTFNINDLWVSAAVAQDSAVFEDEEETEDDQEGIEETVPDTSFASPSLHALSPSTHDSPQADLSFRRSSRARLTSMGNISLHRNLPGHRLSVSHGGRRFSTTSGHMPAIFANTGVKTPPAVAAAYEAESPRHEAESFFGAASPSPDHGRGSSRGLGAIAEAPGADVAVQIAEKEASSFSLLPVQVIIQYGLLALHNTIHDQVFLSFLVTPYRSGGLGLNPAHFSLVVALMCLCQLVYQFYIYPRLGPPLGRFTHLQMFRIGCALYLPAYFSLPILHKIASPDSEGSFFLMLCLVTITAVRYCAGTFAYTSVMVLINAMSPPHVVGLANGLAQSTVSFSRFFGPVIGGAVWSATINGNPSGYPYGFYFCTVGCLIQWLLSFFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ51</accession>
    <name>A0ABR3BQ51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613286.1">
        <property type="nucleotide sequence ID" value="XM_066758838.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991217"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="158"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="524" mass="58456" checksum="60D45E004A5566FE" modified="2025-10-08" version="1">MRTALQSTAVKTSSSRVTLAPIAGPLHYAAQFPSNFGLSRLPCGRLSAVADIRHIHSTREAWKEKQNLTSTTTHIVEARASFKDPVTRYEHLVKDKVLRSDSHQKAIIQKLQRLWDDLKDYDPGPVPAAAVQPSSSFFSKLFCRGPSHPEATIPLSNVPKGLYLYGSVGTGKTMLMDLFHSTIPKQFRPTSQGGYGSTRIHFHAFMLDVLQRQHKLVVEYEKAGLGKKDVLPEVARSLADEGRVLCFDEFQVTDIVTAMILRGLLERLMGFGVVCIMTSNRHPDELYINGIQRQSFIPAIELIKERFEVVDLDSGTDYRKIPRALSKVYYHPLSPAVKSELNKLFDSFTSTDRVSSEVIHNRKIHLWGRELNVPESSGSVAKFTFADLCNKPLSAADYLEVTGKFGTMFVEDIPRLGLGERDQARRFITFIDACYENKTKLFCSSEVPIFQVFSDKHGSAAENAHIQEVMDELGLDPTTVGSSSLFSGDEELFAFARCVSRLSQMGTKEWSEMAGPPADVQAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ53</accession>
    <name>A0ABR3BQ53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613279.1">
        <property type="nucleotide sequence ID" value="XM_066758831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991210"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="223" mass="23608" checksum="302EACC4683733FB" modified="2025-10-08" version="1">MSGPPPIPSKTRPSFTNPFYRNSNASASSTASSPPSYATHPSHPTQPPRPSATQQLERVQYSSLSSLTKNKPKHTHTSQPASYEYQPDPSRQGYTTDGFESHGQAVNQNVNAGRRLPPMPSQATTRTPTEPPQRAVHSASAPPAPPPRTGSGFQSYIPSGAQSGFDSAAKGVRGAADTMKDGFYTVANQQRKEQVMSGIGKLGVGAVKLAGKGVYQVGKFATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ64</accession>
    <name>A0ABR3BQ64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613301.1">
        <property type="nucleotide sequence ID" value="XM_066758853.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991232"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="375"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="464" mass="52522" checksum="B7202E0216D0DF07" modified="2025-10-08" version="1">MTSTKYGIHAYPPKFSDPQFIKRLMADYGQRSMLRPGKGPERTETSDVDRFQFWPDAIAMGSLKGRQFTQVFGAACIKGYDEKSHGRSILAFDLKREVLVIKAEMKLDPKILPPALNPLFAELSFDDINHQGIHITKRPLPHGLTQKDALEVTVTVSCRRPPKFYAPFDPGDKAPDYMACTKYLIDRRRATALDFAVSGVNERDANAIPAIPEGPCAYPTYWNTYRWVFRMGTRQYDRLLACAHKIRALAQADPEMDLMSLTSERARWTVRVLTGEDFKRVYTPSDLSEIPFSSRTLLEGLIGHGIMAPGDTAELITMLRKVSSSTAFHDRILEALFSQQKIRDIKHLIPKLAAFLRRRPPYIQPHLVLIRTVLVTPTRLLIGPPQYEPSNSVTRHYHDKLDGIVRVQFTDEEDRLCIADYMKLVDSINPAVGIMARVRRALQFGLIIGGKTFYPVASSASQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ94</accession>
    <name>A0ABR3BQ94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613171.1">
        <property type="nucleotide sequence ID" value="XM_066758723.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991101"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="732"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="846"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0247210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1028" mass="112299" checksum="81ADBA60A7169D38" modified="2025-10-08" version="1">MPPDNRTSSSSSAQTGSKKRSTTPKRNAIACLRCKERKARCVPAPPGSSPVPTCTNCLGAKKDCVYLDRTPNEIFLLEYVSQLESRCAALELELRKLNPRSQFSADHIHMPAEAREAAVDKLNAVYPPGPLRMGPNGLRSGDQVATLNVDTGPGPSPIVATPSMETDDRSASRASGIGSGNGALNNESENDDGGDEDDFALGIGMLSLGGGEEPVYVGPSSGVNWARVCATALRRPRDRSQPSHLSRFSYLAPPELASVQSALEYTLHHPTPPLPPPALAAHYLDLVYDHVQSRYGCFDWQTVRYWHENREAICQGRPLWGVGTGKDERRNLASFFLWLCYGYGARLSEGGNLQGAVSHEVYYNAAVACLSTLTSHHSLATVQALVFLTIYGFRHPTAEVSVWQVGGLSMRTAVELGLHRRTRSKAEREKDPRRYEMKKRVFWAVYSLDRMMSAQLGRPSGIQDRDIDVELPLNVDVDFNQPRALAAMQSQQLDMMDGKRPGDEYANGYGPVTSMTSAIHNIRLNQLKHRIQDAIYRLDKPLFPTKDVLTAERQSIPEVDNLLVCLDQWRACHPNPPPGVQVPMLSREHWELEYHNCVQMLLRPIVASRRAGKEYVSHCLKSAAALCETQYANLQPPIDPSKLSAWRFYRIFLAGMTLLHVVTTLPADLSEHDRRRAENAIRQCEVSLGVWGEGFRGAKRHEKLFKELVTAWEARKNDESKVNAPKALLPITSGCSQQPKPLKPPAPRHPTPQSEPRADVMSQFLHLVNLSQSTPTRPEQLGGQEPPAPMQALYAADVTCSGGAGVKEGECLAQAKKVMGFNGAEAAGGANTGLSSVFGTMGGPPSATNNPSARNIPSQHPGPEGWRQSVAAVGDVHTGQWTTDVYLDNDGGSSHATGGGLGIKDDFFSLISSFGLDTNMQAPLFAFDGSEPTFDYYPSHQASATYIQDPQSQNPYAVGNNSMSEWNTGTEGMDMLDGSGLGGMNILSLGMNLGGGMDSAMSHDANMGMSDWALFDNNDNRHEPKFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQB7</accession>
    <name>A0ABR3BQB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104407</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613332.1">
        <property type="nucleotide sequence ID" value="XM_066758884.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991263"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="403"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="88056" checksum="B679C330396DDF33" modified="2025-10-08" version="1">MPDRTPTSPRAVVIDVNSPQIGRPIPITSPNVLTPSRSIGPPSMAHRSSVSRKHRPANDADARERQTQQDIESAMSMSRARSGSMNLPDSSPPISRPSQLHFPSTSPIQESPFPRLSEAEEAEMERARRLRPGHDNESDDEHGHGGHYHSHDEERGEEDRGRRDSITESAGYDSHSRLIHRRGSDSDIHHMDRARHVDLRSLGGHGLKNKFNFSAMEEFAARERENLFASEGAWAIDGDNGVLRRRSVPHKGVGASEENIPPPDSYDTAFDRNPMFGFGDETEPPFSPDRGHGAEDHAQTFQRRRQRKLSQSNPVHRQKKLALFEGFGTSGVTDGESVPDAPSAAFKAPRQAKSGFAPYSDAAPGHDRPYRFSFYSNAMPVTIHSRSLAELPAEGQTFEDLFKGRNLSGNASPSDNDSAPRTERSDTPNKPAPSVEPSTMASAKTAPSLLTKAVGAAMSQQAGSGGQPNGGLDADEDPEQYTWWLDVLSPTDEEMRMLSKAFGIHPLTTEDILLEETREKIELFRNYYLVCFRSFDQDPYSQTYLEPLNMYIIVFREGTLSFHFRGTPHPQNVRRRIKHLKDYISVTSDWISYALIDDITDAFGPLIQGIEFEVDSIDELVLILKEAEQSDMLRRIGTCRKKVMGLLRLMGNKADVVKGLAKRCNEQWLVAPKSDIGLYLSDIQDHLITMTQNLNHYEKILSRSHSNYLAQISIEMTDANNQINDVLSKLTALGTVLIPMNLVTGLWGMNVHVPGQDIEEGYTWFGGILGCLCLFAVLGAWATYKCFVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQC5</accession>
    <name>A0ABR3BQC5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613201.1">
        <property type="nucleotide sequence ID" value="XM_066758753.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991131"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF22">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G11480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="685"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="708"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="735" mass="81105" checksum="F77F09410847969B" modified="2025-10-08" version="1">MDVLDLVNDHNHVEGGHNGQTRPYVCTFGTCDKAFARKSDLARHYKIHTNDRAFVCTYRGCGKSFIQRSALTVHYRVHTGERPHHCETCNKAFADSSSLARHRRIHTGKRPYACYAAGCGKPFARRNTLLKHFKRQHPQLPPPSTSAQRITVRMPVQSLGPRSSTASLFSQQSFNSNEERYSPRPTIAGAPHGFAAPHPPKGAAYSLYGGFPEQVLGVHQSTQQPIIFQGSGGIRPHFQQSLITSPISTSRSHFVGEHAAQTPTSPAHHEQDKHSLSPVPSIATKDFGLGQYASPLSAYPHASSYPLTRITSDSGIIWPKSLSAAVGESRYEASQWSGGNVGGGFHASQLSVPHTPTHLSPSYPYHLPMQQRSATNPLPKTRQLYSPSCNGSDDEQDEPLVSLSDAHPNFAIHPPQGTVGAPMSNVEVPNVSHMPDHGAQILFAPSQNGQHHSSPPAIQRFNSMPAVPTMSSWGQISEYQTQSAGDAKSADEEWEELEKEMLSREMSVGADKELSPAAEEEKTPKDGEPINYWGEPIAYPAHPDLQHRKNPFHSISSNFVHHMHSSDPLPPIQIFSNQPHHMVLTPINPNGMYPTPITPGQDWAQRHIKPTTMLGQGHPQQHTNVKNKENGNEIIEHIALTTPPKHQGHRKDERSVTALGLGIANVHFTQSHVIDMDHALEVEMEDLESEESDGTPEDDTDDEFVLGRKPRKNTKKGSVRKRGARTATKRRRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQG0</accession>
    <name>A0ABR3BQG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613388.1">
        <property type="nucleotide sequence ID" value="XM_066758940.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991319"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF30">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="392" mass="42443" checksum="1904A408B33C209A" modified="2025-10-08" version="1">MSFDAVVIGSGVIGLSIARELDNRGLKVAIVASDLAEDSLSVGFASPWAGCNWYSFAEGGTPAAEWDAITFGKLAKLAEDHPDLCEKIPFCSVWDLPKSDAESEPWFKDLVFDYKKLKSTSGQHLAGGKKFGYSFKSYVLHAPNYIRHLSSEIHARGIPIHRYRLSSIDEAYNLPGIGKVFLVVNASGLGAKTLIGVEDEKVYSARGQTVLVRAPGFKACIMHTEGFYADLDESGREITPPSPAYIIPRPGPEGHVVLGGVYQKDNWSTLPDLKEAERILKDCYNLAPALAGPNGKSWKDIEIISHNVGLRPAREGEPRLEIEEREVGTGANAGNGYEVAPKFGCEGERRNVAVVHAYGIGSAGFQASLGMAEKASDLVEKYLSGRRTSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQK7</accession>
    <name>A0ABR3BQK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613436.1">
        <property type="nucleotide sequence ID" value="XM_066758034.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990396"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="88"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="90"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="157"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="226"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="284"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="337"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="530"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="590" mass="64006" checksum="4D01AAD3A9A1A761" modified="2025-10-08" version="1">MPLRRSTSRATSAKPSSRAPSSRLAKVPDASVPAANGNAKRRRVSDADEPVAKKGRPSTASIASRGPKKIVQGINAIPSIPPVKTPHNALFVWGTGDQGQFGLGPDNLDEIGRPKLHSWFEEQIEEGNLSREGKPGSGGLESVHCGGMHTLAIDEAGRVRSWGINDNAALGRITTDVSDPKNPGQMIPNEDLESYPFVVETLEQEGFRAVQVAAGDSISVAISEKGELRAWGSFRSNEGILGFDGVPGHAKFQYTPISLPALSKVQITQVSCGADHVLALTTTGHVYVWGKGEENQLGRRIISRRRINGLEPERLGLRNIVHVAAGIYHSFAVDNKGVVYGWGLNTFHQTGVAEHQDMIIAPTVVDALHPDKHNGSKVIKVSGGEHHSLFLFDNGEVWGCGRCDANELGLPEDHPAFEGIKERREELQREREGRVVEKQKKLDEVLKKGKVDEEEKQKAEMELSEAQATLKVPPSGEYVPEPVRICFPPIPEKYEVVPEFPAYKDSKPEDNPVVDISAGMRHNLAVSKSGHLYAWGYGNLAQLGLGSEEVAEVPSLVRSKLLRPYRSVAVSAGGQHCVALAAKKPDGEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQL2</accession>
    <name>A0ABR3BQL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613150.1">
        <property type="nucleotide sequence ID" value="XM_066758702.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991080"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF89">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="641"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="802"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="855" mass="91305" checksum="CC68C6D4C6CEB18F" modified="2025-10-08" version="1">MSHAPVAPIRQPRGPSTNSFSQGASPPSSGTSGTVPVTGPPAPDTDSLRRANTVSNPRHQPSASISANPAASSAFHGVPSSAAGTSANSSSKGTRGVSRFRSGSLSNTLPDPGLVRRASGREVAKEIVLENEGEGEGIEAASWGRGLSRQSSLPSRRGLKLVQAANQGAAEPAPPRPPRRIAINTNVAGPTPPLSAHSTSHSLSSLSVLHRQMYSSQASQDEPLLSAPSSGVSRTQSLRAQAKHNDAGGLGRSISLKAVGEHTYRQPTSQQESSGQSSNIVSSPSSIVFSPPAPPPVSSTAALPPFQLPLSDSSYISPTAGGADVKRHQSLTHGYGSSSRVRDRLERSPAITLEPREPRDTSGVRVKIDTRFEDEPPTSPIGPSVWSNNLSRTDDGWSSAPLNQNARNASQQLQDAFEAINLGRNMVAPDGSALLANDLDPRGRLGLETDIMRRPQPSSNAPAPGRQGLQRMNSGAEEPSWVNKLVGGDSTPMVGNVMSRSSSALGWGERRGQNETQGFPYGAYNMPFGNGFNMGLKPPVGQMGMPQMGAMGMTGMPMGMPLGMGPLNMGFPMGMNMGFAQMGANGFGQFAPGHPGQVFPSPPNTAAPTGHGIGAQDREVIELARRKGLNPATFNCQPQNARFFVIKSYTEDDVQKSLKHEIWSSTVLGNKRLDAAFRETANKGPVYLFFSVNGSRHFCGVAEMITPVDETKTSKVWAQDKWKGIFEVKWIFVRDVPSSALRHIRLTNTPECKPITNSRDTQELPYEAGTEVLQIFLDYQTKSKTSLLQDFAYYEQLSVNRQNQNSPENGNSQNQQPSSYQQFQQKPGIAFGPPMSINLSGSTIPPVPPIPDKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQW3</accession>
    <name>A0ABR3BQW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-22 sterol desaturase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613529.1">
        <property type="nucleotide sequence ID" value="XM_066758127.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990496"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11082">
        <property type="entry name" value="CYP61_CYP710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="59807" checksum="FB5464417D8DC2FD" modified="2025-10-08" version="1">MESHTILRPTAIPDLAAIKTWGLEGLTKAKFSFDSKTTTATILTLILSLLVLEQLVYRAKKAHLPGAKWTIPVIGKFADSLNPTLANYKAQWNSGPLSAVSVFNIFIVIGSSNEMARKILNSPNHAEPCLVASAKKVLLPENWVFLHGKVHADYRKALNVLFTKQALSIYLPIQERIYRSYFNKWMSDPAPAQQYMMKMRDLNMETSLSVFIGPYLTEAQKQEINEKYWLITISLELVNFPLAIPGTKVYNAIQARKIVMKYLSAASAASKIRMEDDDAEPECLLDHWVRAMILARRAQDDGEETKLLSREYSDHEIAMVLLSFLFASQDAMSSALVYTFQLTADHPEVLAKVREEQYRVRGNDLERPLTLDLLDDMVYTRATIKEVLRFRPPVIMVPYMTTKPFPVSPEYTAPKNSMIIPAFWNSLHDETCYPEPDRFLPERWLPQADGSAPIADSKPQNYLVWGSGPHKCIGGQYASMHLAATLGTASVLMDWKHERTELSDEVQVIAAIFPKDHCLLKFTPRTPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR42</accession>
    <name>A0ABR3BR42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Charged multivesicular body protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613626.1">
        <property type="nucleotide sequence ID" value="XM_066758224.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990598"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24117" checksum="AE69913CCEEF5293" modified="2025-10-08" version="1">MNRIFGTGKAKPKPSLADAIASTDTRVSSLEVKLRKLDAELSVFKNQMSKMREGPGKAAVQQRALRVLKQKRMYENQLGQLQQQTFNMEQAAMTTENLKNTMATVDAMRVANKEMKKQYKGIDIDKIESIHYDMEDLIEQANEIQESLGRSYGVPDEVDEADLQAELDALGLDDEPIGENETPSYLQDAQSLPDFVDSAPLEELQHEQPTAEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR64</accession>
    <name>A0ABR3BR64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613471.1">
        <property type="nucleotide sequence ID" value="XM_066758069.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990432"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF160">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="66590" checksum="57B5DEB0A48BB912" modified="2025-10-08" version="1">MEIPSPTTRQSSRARLIPGSQHGPSHLSKEITPGACAMILERLVPFRHGWSSVDTRRAGVFITCVAVGLASGSNYGYSAYAPQLANQLVISATLVNLIGLAGNFGVYTSGPLWGKIVDSKGQKIPLLAGGLCCLLGYGITHAFYTHMISLRSPSSDNPSYLRLSLLLFAMFLTGCGGSAGLTSGVNAVAKSFPDSTRASTTGAVLAGFGLSAFLFSALGHLFWPGDSGGLLALLALGTGGPMLFAAFIIRPVPPEGEADLGPTLYGRVEQDENEEEMGIEVVVDDYGTPTLSRSSSFELRRSMEFSRSRSPAARGCHINPDPDHPLPHAHFGALPPSHNAIHKPLHSRSSSLSSLPPTLLTHSPTDLLKKTDFWLLFIILALLCGTGLMYINNAGTIALALAREGKRVYDKEKIGGWQAKQVGLVSIWNCAGRVLGGVYSDFCKTHFRIRRIWALPLVACLFILSQLSALSTTHVQSLWIVSSLLGVAYGALFNVMPMLILEWFGMRHFSQNWGWTAVAPIIGSNAFNVLFGGVYDAHTVGRIGPFDPEETDASEVIGMMDSIKRGGVALPDDISHECLVGEECYGSAFKLSLLACTLALGLSVLAGVRREKMSKERRDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR90</accession>
    <name>A0ABR3BR90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metallo-dependent phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613501.1">
        <property type="nucleotide sequence ID" value="XM_066758099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990465"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07406">
        <property type="entry name" value="MPP_CG11883_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041821">
        <property type="entry name" value="CG11883_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="67"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="5">
        <location>
            <begin position="360"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="621"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="661"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="86257" checksum="B8576629F8974177" modified="2025-10-08" version="1">MRTIPLLCFNDVYRVNQKYNPQPGAPEDNSSDRTITVSQFAELLLSERSKWDDRQSDDKDDQEGPSKEGLVLFAGDVFNPSVESSVTRGSHMVPIMNALKVDYACVGNHDFDFGFPHLTKLIESTSFPWLLSNIVDTNTGRQPEPLKRFIVTERCGVKIGLIGLVEKDWIATIPSWPHNFKYRCMKDTALELSQELRDPKGEHQVDIIIALTHCRVPNDIRLATELGAVADKPGVENEHGIDLIIGGHDHMYYIGKGATSWEGYVGQEDVLGTKEDHGVRLIKSGTDFRDLSSANLTVTPAPPGSIRRQLVTSLTGKHLYVLPSSPSSPQFEELVKSLLSSVSEALTKPVCFTLTPFDARSEVVRTQESGLGNWIADVLMHAYAESIVQAKDKEGGFEEQDEGDADAAILCGGTLRGDSQYGPGKISLGDILEILPFEDPVVCIELDGKGIWNALESALSKWPAQEGRFPIVSGLAVKWDHIRPPGQRILAIHQLARSKKDDDDWEDPADMVDFKEREDGTTVVVKQKKLQLGEEVKNEEGGRMYKVITRDYMAQGYDGFEALKNRNFIVDDENGQIMSSILRSFLLGSSYIFRHKQLEEAAHSHLSRRTSQVLSRARAELTSQSQSSPSTSLSSSPTKNLLAAQFKLSQDRMTSPNHFTPASLPSDALSPSSAISESSPWGRLRRHVVQHDWGTIRNALHVAKHEHMSGLDVVAGQAMRQARNHMPGAWSPVQTTPTQEKPQYDGIVLPKDDGGEANVADLAIVSPLVDGRMRDISAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRE4</accession>
    <name>A0ABR3BRE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103835</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613718.1">
        <property type="nucleotide sequence ID" value="XM_066758316.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990691"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="109"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="302"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0247757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="345" mass="37978" checksum="E90DAE9ADEA44A6C" modified="2025-10-08" version="1">MPRLDPSPVRQGDPLSEHRLRSLWLRTKNLPHDVLHRYHRLGRKGKASIWIVTAINVLILAAIIIITPTRIGLWFNSLALSVKDMGWKGVVLCNVFAILSSHPPLFGFMPTLTLIGFVYGIWPGFLIAGIASMLGAGIAFLSVRSFFLGVFKKNDKWEAFGHVMRTKGLPLVIMIRYCPVPWGVSNGLFASIESVKFWHFMVANLMIQPKLLLYVFIGSRLTSLASDSAAHDPLRFWLNLISIVVSVCVSIATGVIIYRLTLQQMRKLDQSGAGFGDGELAAEALEENTLLGDYDVGSDDDEAELLTASNDRDREGSGKRLKVGGGGGIIRRNSSQDTTDSTDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRE5</accession>
    <name>A0ABR3BRE5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1690 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612825.1">
        <property type="nucleotide sequence ID" value="XM_066759338.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991732"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18162" checksum="AF2EF84AFBA8D99F" modified="2025-10-08" version="1">MGAAQSSQPAQDQLIHPQEPSTSVQFSPALISRLSSPHAPAPPTSTTDDIVRRRLAAESAHLRSQEAEILHSISAALEKENLDREKPGMSAQVLGRDIDEIREKVERMKEKRNNESEGVRLARQGVEQCYLTHGDKPLDCWRQVEAFKAEVAKLEQAFVKSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRF6</accession>
    <name>A0ABR3BRF6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613732.1">
        <property type="nucleotide sequence ID" value="XM_066758330.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990705"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="15556" checksum="A087227BA6A95F7B" modified="2025-10-08" version="1">MGFLDSNDGVSSVISQQTSAAEETIKTSAKSAATSKASADDNSDKATSAAAAVTSAPQTSKAAETSVAVAATSEKSGSNSSNGVADTVSTCINQGLDSAGCQSGRAANEGAIIGGAVAGVIIIGLLIYWLLRRKKRQGVKKGFWQGKAMGGTGPSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRM8</accession>
    <name>A0ABR3BRM8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613808.1">
        <property type="nucleotide sequence ID" value="XM_066758406.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990781"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26436" checksum="F5595F0B5171FB81" modified="2025-10-08" version="1">MSPKRMPRVYLVRHGETEWSLNGRHTGVTDLPLTANGEKMVLEMSPRMIGEGKLINPAYLRHILISPRQRAQRTAELLFGENKPPVCNIITDPDVAEWDYGAYEGMLSKDIKKERPNWSIWDDGCPPGQTPGESPAQMSARVDRVIAKVRALHEKAQNAVENPEEADYSDVMIFSHGHFSRCFIARWCDLPLKAGYHFAAEPGGLAVLGYQHKSLKEPSLLGLNWYTEDALERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS17</accession>
    <name>A0ABR3BS17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612798.1">
        <property type="nucleotide sequence ID" value="XM_066759311.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991705"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0245714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="287" mass="30555" checksum="E21AB94C73B87688" modified="2025-10-08" version="1">MTPPPVSDPKSTFKPDLFKGKVLFCTGGRSGICYQIVETMMSLGVDAAIVGRDAKGLEESAKRLEETTGRKCIPAPADVRQPDQLREAVKRTQDAFDRIDFVICGAAGNFLAPISGLTERAFRTVIEIDLLGTYNTLKATLPLVRSCQGSYVHISATFHYRGVPYQSHVGAAKAGVDALSHSIAVEEGPWGVRSNVIAPGPIAGTVGMDKLGVKGHKIEGEVPLGRLGSTVDIANAAVFLFSPASAWITGSTLVVDGGENHIRTAMLPYPESLLDPKSVKGLIKPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS46</accession>
    <name>A0ABR3BS46_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613663.1">
        <property type="nucleotide sequence ID" value="XM_066758261.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990636"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="216" mass="23679" checksum="5200A46B6F5CEB1F" modified="2025-10-08" version="1">MPRPSISTALARLSIRSLQTSAPLPPPTTSLPPSSSTSPIPNLPPLLPSTASSSLPSSTSDALSLIKSQSTPSTGRYILARLHARTYLLHPRDILTLPTLKPLQAPGSTLSLTKILEVGSREYSLRSPAAQAKELKKGLTWKEKKTVEFATIPPEVVRCELTVLEHTKSPMERLLKKKRRKGYKKTIEHKQGWTRLRVGDILLGEGNMVKPEGIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS84</accession>
    <name>A0ABR3BS84_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614001.1">
        <property type="nucleotide sequence ID" value="XM_066757617.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989972"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027842">
        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="2">
        <location>
            <begin position="703"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="879"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0249814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="892" mass="99982" checksum="9E217D683419E95F" modified="2025-10-08" version="1">MSAPATRSEISHNPGKMSVTSAVSGEKVEEDVQSRMKLYGAIQAFRDGRMPDNEQIGSVLEYAIAHSPVDLQKLSPEGRVLIDDFRDTLETLRMIVHEKNADELFQNAVWSSYHGDVSKAKQDGVIPVSNEQAKQDGKTAASHIRVLITLFLTNSEARKLLKDFGIVGRDIFATAATKAADKARPSQEQLDSVDQEAPSHEWIGADGKKLGPNETPDLQIKGPGGTQARYHPRDDPRDAQLIDDKGNSRTAGQAYDQAQEANADAQSKAQDLKSSASENKEPVKQQARSHAQDIVKGAASDKRDAANAQANQNLPDPNDEGNQQRARGKAAELRDRIPEEHRKKAADYIQKSKNFMNDEFPEERRDQFIYRLKKVVVECQGHKDYQEAMTWLLDTLENYKGHAKHVANKGAESAQTVANDPAVGDSTIQFRTLLERFANGKSLDNVFSALDQIYTDVQNDSELREWFTTLNDYMHRVLLEPGYILDEDSDREAKELRESGRKFFQDKYKGHQELLFDELQVWLTAFGEDPLNVRLGDDIKRFCKDLLFNHEGNLTFKPKLWNDVRQVLLPMLLKQVNYVPIPRAEYSDNSIDLVIEDLILSGPNLFPNIVHIESFNSFTFSPYPKLNQTMDNQHHKFRLGLSQIQADIRDVAFAFRRKSGWPKLSDHGLADVILAGKGISIDVELESIENRRDTVFKTNFVHVSIDTLKFSIRNSKHDLLYKFIKSTATGLIKRAITAAVQNAMHTALGHLDEQLVEVRNRVEEAKQSDETTRTQALKDLYARKKESAHEKKAAADEKTGTFKIITDRDSQLNPELTHDGGKSWAKRAFKVEDAARTGKEWRSPAFNLIDPAHPAVTGKPHPAVQNADDGANNLKQKAEAAASGVAAGTKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSD6</accession>
    <name>A0ABR3BSD6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612918.1">
        <property type="nucleotide sequence ID" value="XM_066759431.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991827"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="481"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0245834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="79594" checksum="B1A0DAE0FD9C4859" modified="2025-10-08" version="1">MPRHVVRPLSKAFQPHRESPSHTDRNMWETLDRVQVLGENQQGHYGCVNALSWSDDGQTLLSGSDDRRICIWQPDTTSHFSLSPHPLKLSETISTGHRANIFSAKFLPYANAPRIVSAAGDRDVRVFDVEILGRRMGEAGDWELDGVSGAGVTLLKCHKNRVKRIATENSPSLFLTVSEDGTVRQHDLRRPHSCSSECPEALFQAPRGVDLYSLSVSTVTPHIFAVAGTSPYAYICDRRMLPRQTPSWGPHIKSAGDVYCVRKLGLPNEEWETVSPRSRRRLFDGERHISCVKMSGENADEVAVNFMKHSTSLFSIHDSPSSPSARTPSASSIVAPEPSFGRSRHSISHGPSSGLPQSGAGEGAENKDEPVLSERRMPTRSDNDSERGQDGRQISTDEGSASGHVEGLASLLERQIAEEEAEKEGDNGDDPHFTHIRDLAQDFRHDSGDSITIDPELDLEERGDGMEYLMSSDFVDLERNVMDEDGDNGDDHSVQNPDHDRDNPEDGNDAQNEDDDEDEDEDEDDEDDEDEAMFDDDEFFDSPIFGFPFGGHSSTAPREAYDDVEIIHPRRVFKGARNVETVKDCNFLGTKSDKIASGSDDGYFFVWDKETGKLDGIWEGDGSVVNVMEQHPTLPLIAVSGIDSTVKMFSPIHNRPAPSISFNRTHMASTIVDRNTRVPRFVSGSIFESAALLQLLESRGVTLADLEDEGDGERECTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSQ0</accession>
    <name>A0ABR3BSQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Patatin-like phospholipase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614167.1">
        <property type="nucleotide sequence ID" value="XM_066757783.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990139"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="301"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="678"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="835"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="332"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="747"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="763"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="835"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0249980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="904" mass="100437" checksum="BDFD28983C2AEB72" modified="2025-10-08" version="1">MPPSPSSPPAADPWNIDYVNEDHLKAFAQALSYNDVQPLDGDSSPLSPRPLSLPPESPRLSTAGLKPPASTWNYGPDDGTQRSGRDTEGRVEKLTATSDFAPIHQRVSRRRQRATSQGFTYNVIRWPLLFLIFFIIYLEFSAYVVTRQVVNVFEWLVAWRGYKAKLRKELRKAKTYDEWVDTAKKLDKHLGFDDWKDVEEDSYFDWALVRRVRRTLTRLRAANDTRGVMDVLAVCVRTNFAGTESVKMYSETFIGTKKAVEAHIKEVATCLDYVRTATDVSLEEKRAFFRAVNKHYGSSALCLSGGASFGYYHFGVIKAFLEADLLPRVITGTSAGGLCAALLCTRTNSELKELLVPELADKITACSDPFRVWFKRFRQTGARFDTIEWARKSMWFTRGSLTFKEAYAKTGRALNISVVPSDRHSPTILLNHLTAPNCLIWSAILASAAVPGILNPVVLMAKDRSGNIKPHNLGGSRFKDGSLREDIPLGSLHTQFNCNFSIVSQTNPHIHLFFFAPRGSVGRPVAHRKGRGWRGGFILSALESYIKLDLSKHFKVIRDLDLMPQILQSDWSGVFLQRFSGDLTLTPRSTIRDWFNILSDPERPQLERMLRVGERVAWPALRMVRNRMTIERAILRGRSEVRSALTHDRTSNDPATSLPEANPELTGALDHIPIESDADAGFASRSRRARNKTGSKGGDTPEEQLNLEGVFQPDESSKGVRRRKPNGKKGGAPLTSGLLGDLPEVSPTHSPKATESAQRSYTSNLASSNNAQSPSSSHKPRSQLSITRWFGGVSESSSDEEDEDLGGLQSGGATAWSVEENIPTFQLDSVVDSHFDPSEDEMLHPRANFKEEYQSEGSEGKIPIPGGERVTQEQIDASMASGERLRPVGESEGSPTTPPDQDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT48</accession>
    <name>A0ABR3BT48_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614315.1">
        <property type="nucleotide sequence ID" value="XM_066757931.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990292"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="174"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="541" mass="60177" checksum="A00D5726F77A9B17" modified="2025-10-08" version="1">MAHQYSPPPESDHGHGQEDHHTLPLYSERHRPLGLHHRPSFLDEIVPLPSPSHFTPVGKDPRTHALRRSASVAIISIFLLAVIFMASTESGSTAKEAAARLKGVFGIESVAELGEAIAANLSLDDEEQSTNTNDEGLAAETGENSSTRPQIDFDQFTMIKSVDPKELDLSPGHRIIFVGDIHGSYDPLQRLMSELQYDDNNDILFHVGDLVAKGSKPEQVLQWMREHKIRGVRGNHDQPVIQWRTWMEWAGGVEWEAYMDLLSGKEGDEAIQILDKDKKKYPDDWIWKGEHWNIARQISKESYEYLTNLSLILHLPSLHAFAVHGGLLPANPLKSSSDPSQPLVEYSNSTLSPPYRKAEELAIVKNVIQNTIPYNLYNMRSLFTDGPNKGKVTKSSTKGTPWSEVWNKEMKRCKGPGAWTTEDEGDEWQVEQEQVDDVQLENEEELDGPVKRQKPGTPEAEKQKSAKKKLKCSPVTVIYGHAAGRGLDIKPFSKGLDTGCVYARQLTALVLGDLTGLDGQSVRVGNHKGVLVSVDCGEHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT75</accession>
    <name>A0ABR3BT75_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase mitochondrial F1 complex assembly factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613839.1">
        <property type="nucleotide sequence ID" value="XM_066758437.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990812"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="43190" checksum="E1B711E812713321" modified="2025-10-08" version="1">MAYRTLTHSFSRSLVTPARFPYRSLSTSLRRNDILSELEEKLHPRELVEKKKKLMEEKYGEKLKKAAEKEGVQDIEELKKKVLQPKIDAAKEAARFTEEKIKAEKQLKEDPVEKKVVAERKKKEKREVSQAEGDKSGIKPLSSIINLPLIHLTPHDTNAISQIWNAYHTSHPTLSNSFLSASLPASTYASMIALAKQNPFFVIPLPRLSEAPVEAANHPEMKTDEYEMFYLQWLFHPTPTASSPPSSEANPEPLPLTTSAIFTPLEEFKKSGEWAQPHLILTHYPDLAQTHSLILMRGEISPASASGPPGSLANPGFLLSQQQAQLLALALQRFYCTDIAMPGESDKQQGERLKRQDALRGFRERPEEWDWMGLVEMAYGGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTI0</accession>
    <name>A0ABR3BTI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102427</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614441.1">
        <property type="nucleotide sequence ID" value="XM_066756972.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989284"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="39"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="155" mass="17573" checksum="615F880F59B9F3CA" modified="2025-10-08" version="1">MSQPISKLDNPSTLLQSVSSNAVHEKITILPGHGPDYSACTFALWQEDHTLGNALRWIIMKDPEVEFCGYTAPHPSEPKIHLRIQMYENQSAVDCLRRALSNLRDLLNAVNDSYSSSLQNDDYLREDDYDVKAAVDETLRERGFAVEEDDRMDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTP6</accession>
    <name>A0ABR3BTP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102499</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614513.1">
        <property type="nucleotide sequence ID" value="XM_066757044.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989356"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="10">
        <location>
            <begin position="226"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="274"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="313" mass="34357" checksum="2F1D26D3AA4F18E2" modified="2025-10-08" version="1">MTPPAKPASTPKRKPFTPRPPRPAEERLPKLYRALTDQVDDGYFENAIKTCKKILAIDASSQTAFQTLLFLHLQTDDYTSALSLLDHPSHEGSLDFERAYCLYRLHREKEALEVLKGLNEKGRKMDHLEAQILYRLGEYSQAQEIYENMLANCDVSSPEHADIVTNLSATTAHLEFDAHGYHSHLSTTISSTSQTPMNAADLESIVPSLPTGWSTGGLAATVEKKTAAVKAPEEKNKRSRPRHKLPKGAVAGNEFTEDPERWIPLPQRLSYITAQSKKKGAKESMGTGFTQGSTGGPSAGSGAGGKNKKGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTU4</accession>
    <name>A0ABR3BTU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613398.1">
        <property type="nucleotide sequence ID" value="XM_066758950.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991329"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="312" mass="33396" checksum="83E1F6EED02D93D4" modified="2025-10-08" version="1">MGATRANKELYFEKLRALIEKYPSIFVVNIDNVSSQQCHMIRQALRGKGVVLMGKNTMVRRAIRTILPEFPQFEKLMPFVKGNVGFVFTSGDLKDVREIIIANKVAAPARAGAFAPNDVYVPAGNTGMEPGKTSFFQALGIPTKIARGTIEIVSDVQVVAAGSKVGPSEATLLNMLNISPFTYGMTVVQVYDNGAVFPSSILDIEEKTLVDQFVSGIKTVAAISLATGIPTIASVMHSLVNSYKNILNISLATDYEFEGSAKIKEYLANPEAFAVAAAPAAAAEASSEAAPAAAKEEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU13</accession>
    <name>A0ABR3BU13_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate synthase</fullName>
                <shortName evidence="21">DHQS</shortName>
                <ecNumber evidence="21">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="21">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="21">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="21">EPSP synthase</shortName>
                <shortName evidence="21">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate kinase</fullName>
                <shortName evidence="21">SK</shortName>
                <ecNumber evidence="21">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="21">3-dehydroquinase</shortName>
                <ecNumber evidence="21">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="21">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="29" type="ORF">I308_102492</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">IND107</strain>
        </source>
    </reference>
    <reference evidence="29 30" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21 22">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21 22">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 22">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21 22">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="21 22">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="21"/>
    <dbReference type="EC" id="2.5.1.19" evidence="21"/>
    <dbReference type="EC" id="2.7.1.71" evidence="21"/>
    <dbReference type="EC" id="4.2.1.10" evidence="21"/>
    <dbReference type="EC" id="1.1.1.25" evidence="21"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614506.1">
        <property type="nucleotide sequence ID" value="XM_066757037.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989349"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03143">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000514">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 21 22" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16 21 22" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="13 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 21 22" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 21 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="17 21 22" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18 21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="14 21" id="KW-0521">NADP</keyword>
    <keyword evidence="10 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 21 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 21 22" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="25">
        <location>
            <begin position="79"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="28">
        <location>
            <begin position="192"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Enolpyruvate transferase" evidence="23">
        <location>
            <begin position="417"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="26">
        <location>
            <begin position="1336"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="24">
        <location>
            <begin position="1451"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="27">
        <location>
            <begin position="1575"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-dehydroquinate synthase" evidence="21">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate dehydrogenase" evidence="21">
        <location>
            <begin position="1331"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="21">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="21">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="active site" description="For EPSP synthase activity" evidence="21">
        <location>
            <position position="845"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate dehydratase activity" evidence="21">
        <location>
            <position position="1220"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activity" evidence="21">
        <location>
            <position position="1248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="47"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="84"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="140"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="180"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="195"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="271"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="899"/>
            <end position="906"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAL0250319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1610" mass="173226" checksum="058998E59A60FC5B" modified="2025-10-08" version="1">MSSSSADVLKISILGNESIHVGFHLLPYIFETVVTTLPSSTYVLITDTNLSAIYLNDLKASFEEAAAQAGNKARFLVYEVAPGEGAKSRKVKGEIEDWMLDNKCTRDTVILAFGGGVIGDLAGFVAATFMRGVKFIQIPTTLLAMVDSSVGGKTAIDTPHGKNLIGAFWQPSYIFVDLAFLTTLPTREVSNGMAEVVKTAAIWKDDDFALLESRSAEISLAASTRPNGSPTAGRFASDRSHAQSLLLTVVSGSIYVKAHIVTIDERETGLRNLVNFGHTIGHAIEAVLTPAMLHGECVSVGIILEAEVARQLGVLSQVAVGRLTRCLQAYGLPVSLYDRRITALPASSQLSVDRLLDIMKIDKKNSGPAKKIVLLSRIGKTYEEKASVVADDVIRKVLCESVTVKAAIPTKSPITMATPGSKSISNRALVLAALGKGTCRVRNLLHSDDTAVMMNALVELKGAVFSWEDGGDTIVVKGGGGILSTPAKGKELYLGNAGTASRFLATVCAMVSGSASNERSTIITGNARMKQRPIGPLVDALTANGAKVKYLESTGCLPLDIETDGFRGGHIQLAASVSSQYVSSILLCAPYAAEQVTLELTGGQVISQPYIDMTIAMMGQFGATVERQKDEQGNLLDIYVIPKCTYVNPPEYSVESDASSATYPLAIAAITGTTCTISNIGSSSLQGDARFAKEVLEPMGCTVEQTLTSTKVTGPPVGTLRALGNVDMEPMTDAFLTASVLAAVAAKSCLPERRVEGLPETASRIYGIANQRVKECNRIQAMRDQLAKFSVETDEFDDGIIIFGKPEASLFRGASIHCYDDHRVAMAFAVLSCIIDKTIIEEKRCVEKTWPNFWDDLQNKIGVAVEGVELETHNQASTSAKPTAAIDQSQSDRPIFLIGMRGAGKTYVGRMAADILSGQFTDADDVFAQETRQSVSEFVAANGWDEFRKKETEILSKFVEEHRGNHIIALGGGIVETETAREILTAHVAKGGHVVHVTRALEDIEAYLDSIGSTAVRPNWGETFADVFKRREPWYQACSSHEFYNVLEAVGCQSQEEHTKAMRAECGRFFKFITGRESNRPRLSAENPTSFLSLTFPDITPALVHLDELTEGADAVEFRVDLLGITGQAPTGPALPPISFVAKQLASLRLATTLPIVFSVRSKDQGGMVPSDNAEAYGALVRLGLRSACEYVDLEVCWPVQVLDSIVRLKRETHIIASWHDWTGDMAWVGEEMKAKHVLCEKYGDVAKIVGTAKSGLDNAKLALFVGEVRSRPGAKPLLAINMGAVGQLSRVLNPILTPVTHDALPSRAAPGQLTAREILQARALIGFLPAKKFVLFGSPIAHSVSPLLHNTGFATLGLPHNYGLHESEKVDQDVLEVIRSPDFGGASVTIPLKLDIIPHLDSVSEDAKIIGAVNTVIPRGGKLHGENTDWQAIRQAAAQNLDAGAFSEGSSTALVIGAGGTCRAAIYAMHKLRFKTIYLFNRTPENAAKVKASFPESYNIIVVTSLPLPEAPAVVVSTVPGNSLTLDTSSEGIYFPSEVLSRPSGVAIDLAYKPHMTALLEAAEKKEGWKVVPGVEILCLQGFRQFEEWTGKRAPEKKMRKAVLDKYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUV5</accession>
    <name>A0ABR3BUV5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 11">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103186</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 11"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614070.1">
        <property type="nucleotide sequence ID" value="XM_066757686.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990042"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0249883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="203" mass="22318" checksum="4A918D5CBD961036" modified="2025-10-08" version="1">MATNITFHPGAVTQDERNTLLGQKGCTVWLTGLSASGKSTIATALEQHLLHKKLHAYRLDGDNIRFGLNKDLGFDQASRVENIRRIGEVSLLFALSSTISLTAFISPYISDRQLARELHEKHSPAIPFIEVFIDAPLSVVEQRDPKGLYKKARAGEIKDFTGISAPYEAPANPEIHIRTDEVDVTGAVEIITKYLVDNGLIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUV6</accession>
    <name>A0ABR3BUV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Solute carrier family 29 (Equilibrative nucleoside transporter), member 1/2/3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614424.1">
        <property type="nucleotide sequence ID" value="XM_066756955.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989267"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="52217" checksum="0C3A9DA8D2D64775" modified="2025-10-08" version="1">MLAAIRRALSGSSSALPDPAEYQPVIPSNAANADPADPATLDHIDRQLGRGAARDAIVYENVKVYFCFWVLGAGVLMSWNALICTFPLLISYLPPDSNLRGNLSSILSTVYCFGNLFFLGMAQRHVGKVSPTKRLHSSLVVLLMTALLTTYPALPALFPILSSSLLLTVLIFISLVLSFSTAYLQSSVFALSSLWGSEQTLGVMSGQGGIAVLVSGVQFVLAFVSAIAKSDNGQGDEGEEASKLAGVGLWAACSLGVVGCFMASRYLKRHPKYLDVVAPKFATSELNGVEGNKRESGTTRKLFKKNWELNLAVAWVFVVTISVFPPITTRILSTHQPTPRLLQPDVFMPLHFVIFNIGDYIGRTYLASYSAHHLTSPRRILFLSLGRTLFIPVFFACNVTPREIGNTPFISSDILYFLIILLFSTTNGYLGSLCMVVSSSPDLNPRIKADERDVAATLASFCLVAGLAAGSLASFAVGAAVNRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUW8</accession>
    <name>A0ABR3BUW8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613788.1">
        <property type="nucleotide sequence ID" value="XM_066758386.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990761"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="666" mass="74630" checksum="24D67F9F8455B60F" modified="2025-10-08" version="1">MEPPQTLASPLRFRHTLGWLEESPPDISNTKDKLVIGIIRALQLMGDFPAVEEYVQSLTIKLFSFLFESNVLIRKSGILWSWRGSHDIGTLRVRLESSPYDTTYIQSKYHRTFHEWRKNGHDKDVPSNAGVRRPDGMLLAYTCHRFASIEEMPQLAVVEEGKIDVLPPATPHCRSVAPVIHTRPYALSDNATSVMSPMPSKTSTRFPSSFVKGLHLDPCEAPYIITPLTIELKPEERDVRLCLLQGLTYMVGAHDTCGSVLGYFGHGRRYCRAIILDGETILFETTNEGDKLASMGGIKELIHFMGDKILPRCYGTYDKPDIKAFEDAYNFALAGLRMVLDLPLGERLCRLKAPSGESWERLMDELQMKAKYPKTREDVEYMFDILRPDIAKKNEQMRLYKEAAMLDKMAAIPSQGTTTERADIVESHEGDKFEVTEEVKTRKAKKKKTSLPEAGAHKLSTRFRDPSPSSDGRGGREVGRGASRGVEGSHQLDRSSRKREAPSPEGGCNQKQSKSNENKGKVLSSVSMDSADSVPLPITPPDIDSEWLFDPFTNGLCTSKEGLKMCSGANSGPENGKLHSPVPELVEEEEIKPPGSELADENEPDIPVSQRGDEEDIVDEMEWREEERKLYLALYSVLEQRGFRFLLGGQKVFQAVLKELTGQYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV11</accession>
    <name>A0ABR3BV11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614951.1">
        <property type="nucleotide sequence ID" value="XM_066757482.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989836"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051262">
        <property type="entry name" value="SMP-30/CGR1_Lactonase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572:SF5">
        <property type="entry name" value="BLR2277 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572">
        <property type="entry name" value="LIPOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="311" mass="34079" checksum="BA5479F20D6E428F" modified="2025-10-08" version="1">MSNFYPPPRIVTARAFSSVPTTLWSTKTSDWLPGSGLPPKIFLEGPTTDTQGNLFVTDVPYGRILRCELKSQVWEVLADYEGEASGLALNDEGHLIVADYKNGLMKCDPKTGEVDPVLLRRNMERFKGTNDVIVARNGDIYFTDQGQTGMTDQTGLVYRLSPTGKLDTLLQNGISPNGLVLNPEETVLYVAMTRDNSVWRLPLHADGTTTKAGKFFTSFGIAGPDGLTVDEEGNLFICHPSLLSIFVVTKHGIPLARIVPPEGHGTSVTNCIFGSTEEDSNRLYFTDSTVGRICYVDWHCKGTTPLRASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVC8</accession>
    <name>A0ABR3BVC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614589.1">
        <property type="nucleotide sequence ID" value="XM_066757120.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989432"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="715"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="459"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="899" mass="99385" checksum="531F8F23056491EA" modified="2025-10-08" version="1">MPPRRAAPQASPARSTRSAQSLTRDHAREEDDWEAAESMTGRSFKVPESRSKKAGTAIGLKDTSVNIAAAFHAAQTGHLPPAPHPNTSISSNASSSRALQVPRAISPAEQLAQSARALSPVRFFLRPTEEDGDDYTSFSSVGIENTGESNTSGEGESYDYRQEEEYVRQVQQQKIARSRAEASTNVKNRRIKAMDEDMPYRPAEEDSVSLASSDSGGGGEGIVKSGALQGRAETRGKRLERGEGYLGMGLGIQPRRRRKSRKSGMDGNESEEEESLRTGRAWTPTVEVGGHRGSPTPLQLLRGRSPMMDRKSPVPLGAYQQRRRPSDIRTIVTNVLHGVVMGLQFVVELGTTVLYRIIVHPIEKAFGSGKGFVRRAKTDWWKWLGILLGISLALRFLDNAFRTKGIYTAPDAPPSTIDEMSIRLTSLEHATATLSDLLRAISEGDNELHQSAVIMKSKIDEIEDAVSAERKRIEGIRGELKKEKVTMQSEIDKLRSEIHILANQVDRHENSLFSDRSAKSLQAVEREITQLKSRMEQVERDVHAALEDGRLVAALERILPQWMPIRTDSQGNFVVEPAFWSEMKKVMVGKGEVEQIVRRLIGEAGVSGTKIKESPVDEQKVMEWMDKAFDRHLQGGVWITREEFISTLNEKLQELARETPEKPTSKRPAASSTVIIKSSKGEDLTSLLNSLIDTALLKYSKDTIARADYALFTAGARVIPHLTSDTFTLQKASTFGKLLWASKDVQGRPPATALHPDTSVGSCWPIKGSEGSLGVMLVDRVVVSDITIEHAPQELALDIATAPKVVKVLGLVDYAEGLEKLAEYRATHQMELNHEEDTNYLPLGTFTYEPSSYSHIQTFPVFPDIVELGIRIGVVVFKIESNWGGDLTCLYRVRVHGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVK7</accession>
    <name>A0ABR3BVK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103159</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614043.1">
        <property type="nucleotide sequence ID" value="XM_066757659.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990015"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="10">
        <location>
            <begin position="736"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="11">
        <location>
            <begin position="928"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="9">
        <location>
            <begin position="1174"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1376"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1378"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1397"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1407"/>
            <end position="1420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0249856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1472" mass="166074" checksum="B41FCD952DDC748C" modified="2025-10-08" version="1">MGIPKFFRWISERYPLTSQLITPNSIPTFDNLYLDMNGIIHNCSHPPSSENDPHFRITEEQMILAIFAYIDHLFTKIKPQKVFFMAIDGVAPRAKMNQQRSRRFRAGKDARDQREKAEKNGEKLPDEKAFDSNAITPGTPFMARLSQHLKYYVRKRISEDADWRNIRVILSGHDVPGEGEHKIQEFIRLNKAQPDYNPNTRHCLYGLDADLIMLGLLSHDPHFCLLREEVTFGRKSRQNTELANTNFFLLHLSLMREYLDLEFSSLQTQISFEYDLERIIDDFILMAIFVGNDFLPHLPDLHINEGALERIWGMYKDILPTIDGYLNEHGTISLPRLQLLLDKLAEFEVKRFEDDLVDQVHFSGNHTRDTMVIEKARKKGRKVITKYQQKVLNQLGSFIEKQQNQPNPTHRLELINTQDKRDNAFVQELADELHLHTTWDEVDDYGQSLIVCTFNMEGVSQDGSADGNEEDEDWESDGMEDEGKLAVQRVFRNWSKAAVVDTYPEDVEKSMDEKLKEAMDGIKRQYYRDKLEINYNDPAQMQDLVHHYIEGLQWILNYYYKGVSSWGWFYKYHYSPRITDLKGVADMKFGFDYGKPFTPFQQLMGVLPVDSMEHVPLAYRDLMYEETSPIIDFYPRNFELDMNGKKQDWEAVVKIPFIDQNRLLKAMAVRDVRLTPEERERNKSGVLSTEFVYDPEIDENYPSSFPGVFPELTRSHCRASPFNLPVLGGDIQLIFGLVEGVQLGVSALAGFPSLDTLPHNGILDYHGVNVFQSESKNPSMVITIIGKDELPKTSEIARNVLGQRTFHSWPYLQEGIVAAVSDDMFKYTLQQVGKSLRVVHMPHQDAVKWKRQADHVERHYSRRYGVIIGGVEVLLHIRPLKGLKHLDNGALVKDYEAPEKEIVQAYQMAVSQVTFEDERFLERAPPDLKVDFPVGERVLFLGDMHYGLAAQVSAINEEAQTLSVILAYFEEETEETFKFTKAVAHRPTGKWWPSPILCRRLSISALALSRITSTLLVQLNDGSKANIGLSLKFESRGLKVLGYSKRNDRGWEFSEKTAQVLEAYKKAFPEVFKHLENRGGDLVKSKELCPTAEDPDAVIKGMKKWLKDEGLSDLESVSLFADQLEAETCQIIEKLADDILSKKTFQSIKKKRLDNVPRQTLLKPSQAIYRLQGQVFEPGHRVVMVQDPAAGGVPTGMRGVVVGLGMRTIDVIWDNGFMGGSTLQGKCSPYRGSTVPFSSCLNLTRPQFTVSERAGPKPVPQNVFRPQLGPRPAVPMQHYQPSVPGRQQTAITTPHILHKPKTVHSVQSTTVVGSNGHLKYGGVAKGVRPLPIQQQPVSHRDQLSNLLGGLRLGTGPVVNDSGGSRHITQAQAQGNLPVVHSHASAHQSVSTHPHIQGKTQNMNNKPGLSASRGRGAANGAPFPHRGAHNGVPAFAHGGAPNGAPRGRGGRGGGHRGRGRGRGNGGSSAAIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVQ4</accession>
    <name>A0ABR3BVQ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614370.1">
        <property type="nucleotide sequence ID" value="XM_066757986.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990347"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="612"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="882" mass="96474" checksum="645ACBFFABBBE975" modified="2025-10-08" version="1">MFSARRQSSTSSSNSAVIPLNHSTTPSNDNPSLHLALQGPGSGSNDNPSTSAADGNEKQRPRRKVTIVPPVTTACLDDLRSALPTGTAVPHSFQANVLSTPGLPCPTTEASTARKSSKRRRAHSVSVCLPDSAKYVQLEGENDSALHQNATAGKRGARRQRSHDIELGLSPADTNPAHLPSSSDPTRRHRSLSAASQSALSSHRRLRERRESSPGPLGYEMEGRDGDVELGDELVGVLDVIDPQVSTLNHLQNMCNSVMVPYLPQLWTRRPEVQLPSPVGDGDVGSTATATGRRSDTTRSRRRSLSLSRFVPSKSVSASTPIAAENDAVPRTAPASSGGAHRLSVMEEEPEFQPQDSSIQSLPLTFATKQSIPSSTTSLPLPTKPTSLTSSPSSSTITFRRSSLFDKYIKSILSTSTRQKILLALQGLWTFVKTPMGFLTAIYGFAVVFWGAAIVLFLLGWIPTSSKYRQDVWVEISSQVENGLFTVTGVGLIPWRMIDTYRMSVIWTLKRRAERRREKMNLPPIEDENDLPDPQDIPGYVHVLNEKEAAKLRHHQEKFALSQTWYKPHATATHRAFPIRWALWNTILMDGNSFFQCILCGCMWGMNWHERPAWTTGCLIPLSFLCGIGAAVLIYCGSAKTKKHQAVSEKLRQAMGIPLAIGQPAIRSSNVGEDPISKERGEEGDDGDEDGIVEEGGKRERSQAQVERAPDGGVMVGVGSGVVNRERPSGGDERDNEKDGKDEEDDAEEGEAEDRRGAKHESPNILTPLLRRNKHHLQRRATVTFGTTPSTLPPDPSPLHPQPLPHPNRHHHLLQKRHRDNTMPMRLPYFSPSSSPSPPPALKEEAGTSVKPDQQGKDISSIGVRRVEGSSDEKGDMALGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVU8</accession>
    <name>A0ABR3BVU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615213.1">
        <property type="nucleotide sequence ID" value="XM_066756436.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988743"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="7">
        <location>
            <begin position="94"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="5">
        <location>
            <begin position="425"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="1026"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="641"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="818"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1311"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="863"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="878"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="906"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1321"/>
            <end position="1331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1421" mass="157934" checksum="54DAD23554780689" modified="2025-10-08" version="1">MPSAALSSPSAAALVALACMLLLYIPQLLSFATLCLSILSLALAALFYAALTTDYARTPQLLRHRNALYRLHLNAVPLESPTQSPARSPTSTFSPQVNSAISTFLGLVVQHFVIPWYSRISPSPEFPDAFEEIVQKSIARLVEKSEKVDWPSFMVSKILPIITDHLQHYRAVEHLSLAPQSLPLPLPQHPHKALIDPHLAAQAIEEHFRHSLSRILPDLLPKSEQTPVVLTLVQEILLGSVVLPGFQMVCESDFWNRQIDERVGQYLHERKQVDQFLSALSSIPSTLPSVGSPTATKVRHKSHFKTPSIDANSSSSQFDFFLKSIRKLWTLGEARRLKADVERELRSAKLTLYEENKEANELGLTHQSSDKGASKDIRKAQKYVERLKKAKSAIDSRIVELSGGSKVYGDSEPTLVSSDTTQPISLYTILSNPSSLAYWLEFMDRRHRSRLVQYWLTIEGFKDPLEATGTDVIEDGKPTERNGPHDTAIEDVQSLCATYFSAPQSGSVVISPQNQQIIEAAATSSHNLSPQDIARVRRAVFASQREVYEQMEDEDWSAFGKSELYLKAVGDLQRTHSAVKSSTTAVIADVQQPDNSRAALSRTPSPMAQMHHSLPRHQTPALLHRPLQQITPQAPKMVNSLILSSPPSVSSPSFPPDSSYLQQKRPSLPPTILTVPTTPAGPSISVSEFRVVSPPPFERRISESKDSRNNNSNGSAESRKGSASEMEAPQHQLHSPSPSLSPSYTSTPLILSPKLVSPPPPTAKRSSQLNFLIGNAENSETDGRDRLFRDEPEDLEEEAEREEEARRIEAIQAALSEIIADDNGKRSSDGTPSDVLMNEREKPRNRGNDMTSSLILGGVAAKEGGKRRSRSLEDLKSASLSSTTAFPSDASLSQEPIRNPSKLLFEDDLPEDDLSGTPSEEEEDSDIPHNVPLPAPGDLQLTAQISELGTKLIELEKQNELLSTLIRQAELTGNQKELKILRKSQSSVQRETRAKQWQKQEFERVQDESRLMPSRTRVSIPSAAVTEDTENASASTLGVVGPKQVVRYTIHVCQIDDGHPAAKWVVSRRYNEFWELDKNLREWASEHGALEAIETLRKLEIPGKSLVGNISANFVESRRIGLEKYLQGLMTSTTICDSLHLRSFLSRSNSLIPSTNRTQPAVTQFTKLPHNLMKTFYKSISPGPSSEDMFNANMVDVMYNGLDRQISDLGGLVGLGLGSPEVEVTEDQVQVTRDVSVEGMTSFTGPICDLFIELFDLKEKNWLRRQAVIVILQQFLGGTIERKVRDSFGSITSQSSFLRIIENFQDTLFPSGKRRTSTAPRSEEEKAGTRARAEKKLGLLIPDVAANMIGRGNARRAARRVFGVLQDERLNQQLMLRILDAVMKAIFPSMDGSEIWHFMQDRFERPDDYVLDATSFHYPCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVY3</accession>
    <name>A0ABR3BVY3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102431</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614445.1">
        <property type="nucleotide sequence ID" value="XM_066756976.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989288"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="7">
        <location>
            <begin position="336"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="379" mass="41361" checksum="500CE91B0D853A90" modified="2025-10-08" version="1">MAGLHHASVTKAMMMLLGVSTLASSLLDIKPYLHLQFVPHMTKYHQYWRILTHPFAFANSAELLLGEVLLYGAGVHTERAFGSRKYASFILISSVISTILACAVIVLLHPFGIKSIPGGPYGVIFSILWQRYRMVPPLYQFNLFGIHISQKFFQWIFALHLMLSVPPSSILISLCGLLSGYIYRTDIMFPIPSFSPRSRRFFVRQPLKAYRIPLSIYNLFGRIFGPFVGVSAPPRRSDRVLPGQINERRGVIAGLPAGVAAVGGGGAGTEGTPRPSLRSLLAGRITAESRTQTPGPNAINGGEEGDDEGEGEPGSTRAAMGEWVSGMTGRSGARAPTEDEIGTLSAMFPNLSRETIVRALQRNDYNTAQAVEALLQQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVY9</accession>
    <name>A0ABR3BVY9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615271.1">
        <property type="nucleotide sequence ID" value="XM_066756494.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988801"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="271"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="763" mass="83423" checksum="A591C4A51748E52D" modified="2025-10-08" version="1">MPSSIPDHSIRISIDRGGTFTDVHASIPAANHSKTREEFILKLLSQDPSNYKDAPTEGIRRVLEKVTGQSIERGKPLPVDKLEYVRLSTTVATNALLERKGQKHALIITKGFKDLLEIGNQARPNIFDLNIKRAKPLYSRTIEVDERVTLVGFSSDPKYEQHAVKFNDDGSIAKPYSGVGADEQQVIIPGRIVRGLSGEAVNILREPNLETIKIDLQNLYNDGYKSIAVCLAHSYTFPDHELAIGKIAKEVGFPHVSLSSQLLPMIKMTSRGQSTTADAYLTPILRDYLDGFYSGFEGGKDGSLHVEFMGSDGGLVDLKNFSGLKSILSGPAGGVVGCALTSWDKDEKIPIIGLDVGGTSTDVSRYAGHYESVYETTTAGISINTLQLDINTVAAGGGSCLTYKNGLFRAGPESAGAHPGPACYRKGGPLALTDGNLFLGRLIPKYFPRCFGPNEDQDLDPEASQKKFEQMAEVIRKESGAEKSLDEIVYGFVKVANETMARPIRTLTEARGFKTERHILASFGGAGGQHACEIAELLGIQRVLIHKYSSILSAYGLALADRVFELQEPSAVIFSQENKAGLNVRLDKLQREVLKTLLDAGFAEDKIGLSRILNMRYDGSDTALMISDEGSGDYEKEFKRAYKEEFGFLLNKNIVVDDVKVRGVGKTFDSLGAPPTQEVKDLELSVIGSEHADSIQDCYVWYGKSGKREDVPVFKIESLRVGNTIIGPAMVLDETQTIFVNQGWKAISTSSHLLMVQEEKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVZ9</accession>
    <name>A0ABR3BVZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615280.1">
        <property type="nucleotide sequence ID" value="XM_066756503.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988810"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="822"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1365" mass="148605" checksum="A499BC181D1C6653" modified="2025-10-08" version="1">MSGALRKLEDMTPLSPLKGHVAKSQAENWDDEFEFSLSSPNDYNNSNSTLSENKYQKVQDENWDNTSSAPAALHVHVPCPQSPRHSSSYPRGLTPLSSKSKSSSSNPRPISPLFLSTQSNPFLRQKRGPGFRSRARSMTTINGDAVSKKLTKRPPSASFITIPSSHSSRSLREYNSTTSLSCSLHRYATCPNFMDSCTPPSAMDIPSSASWEPMPLLVLSIRSENVASEGTELLQKKSRTKPKQQVPPLPSSDNITGKEQGRRFWNKFSGNPSSNRERTTTQMRRRSSSIGASFAEVDTTAKPSPEPPLPPLPITLTRSPFTTSSIPSSPMGPPMQRNTMPSISSTLQRSSNNLPKAKRASKEGALPTPYNHSENIAWGEVVIDGDGFSSSGHRNSFSNPEQSQSYSPGFHLPSPSLGSPYRRTRESFYDQHPVPESSSSLHIMAPGQNPASNACVCSKVRSESASEANKINNKALRRRVKDRHSFLSTSSEKMTEELGNDNEVFLMTRARSSTTEDCPVAGSPNNLKAVTAYPTLVGLGGKTSGNGHTGTGSSGAGFVSTIRRLGSISKKHGRRISGGWKFGQQSPSASASLNVQEVTPTGVAFDHSSAEDQVPLGTVIGSPVRENVIESAEDEFVKPAMGLECTKDGVRRQAHCPPSSEEWDQDFPHNESESQPIGSSVKADPLIRTESRRREDKNRRRQSWNSFVIPKNVLEKQKEIKEGIGAIKVFARGVESLKSLIAAHSSLSYQLHCHESSPASLRFDALHAEFAQWWEMAIVLVEVGSTGRDDSSHKPIEGPIREKGIALATEEARIAEDTLRHVSGSSTSTDMSSVPSQGELTPSGQYNVSLPYTAEHLPSLRSPPRASPPPGHWRASTGRQSLSQRQLEVLRTMLRTPVSSSSKGARLVGQQESSHWAGYKTANTTKIQDECNGSIVVTFTTPKNQNHLPNGAALVQDRYVEPIKATTKSKRRHTNKAGLAGLKEFLRSLRMEKSTGKANGQNHSLTAINSQAQVGEGIPAVNGTNMMISRSKMMSRSNMDSSTAAENPPLLEPPLLFRSVSPTGDSCEVSHNSVFASNLQTELSPAEQPPVPDKFPPQPFSLVRQTPLTASPSVLPKSAQNPRIETKRPSIRNIFRTSSGSWGDLINPNSGCPVPLSTKNSSPTLRKRGSMRRTLGQVSGVKDKPKRGEKVDNDGADAKVAVTGALKGRDEFFMDGRGFNLLCDPLPGAYIQTTSSNEISTKATQLRDEEEMPLKPSKKTRAIGLGWPERKAEGDIKDFISPVFSGVSSTTHVSSTPMTHPSGLIVKELGRQDDSEGNVVIALTPDNLPILLEYMRQCEAKLHEWKKKVQIEGLDKGFIMNSVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW33</accession>
    <name>A0ABR3BW33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_101738</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615069.1">
        <property type="nucleotide sequence ID" value="XM_066756292.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988596"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="12">
        <location>
            <begin position="217"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="551"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="572"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0252349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="654" mass="73644" checksum="A35EB3BA61FF4866" modified="2025-10-08" version="1">MSAANLNRSFSVYSIPSQLLQSLAVRSIQAQNSDQQQSVLPTSASTSAAAAPPPIGTGISCQTCPQAEFDTIEEQRAHFKSDWHRYNAKVKLNASGKVVSLEEWDNMVEGISSISGSASSTSGSEQSKVARLLKNQTLDESDDDSSAAAELADRQRRAHLRTAVIWFSPSAPVPQLNIPKDTQFGVHRALFPPYEKAGDYLEELRRMQLSGNEEEDGERRLTFLMVAGGHFAGMVVGIRPRGKTEKQDVKGAGEVRVLKHKTFHRYTTRKKQGGSQAINDNNKSKAISAGAMLRRYGEQALQEEIRALLIDWADDIHGSERIFIRASTHGKKSFWGYQGAPLEKNDERLRTFPFPTRRPTLQELLRCWYELTRVRVSHLSEEALKQQDEAYIASLQPKTQTKAKSTPAPVKEVKSEAPKISAEEEARLDRWQRLEEMVRKGRINALRPFWEKYGEEFLFTPASASSSLSPEEQSQYTQPYLLSAASSSSQPEVLTYLLSELKFNPTLVVSSDSLKRPYDLASSKAIRDIYRKFAYDNPDLWDWKAARVPPGLSEEMEAEQREKKAGRRKGLKEKLKEREKTRQEAEAREAQEEEERRLKREKEEREKPTRLGVSGPQKLGGGSAEGLAGLSAEMRMQIERERRARAAEARFGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWF9</accession>
    <name>A0ABR3BWF9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614964.1">
        <property type="nucleotide sequence ID" value="XM_066757495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989849"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF2">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="215"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="5">
        <location>
            <begin position="215"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="633"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="637"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="675"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="750" mass="84265" checksum="B3F5595F49064D79" modified="2025-10-08" version="1">MITSFTTDISPTSGPSISSPPPLLSPVSPDPSTTISPDKRAAKHGISMCAVRPNCRRVDGHDHHYQHDQDHQMAEGDYGADYVPPKEDGQPKICPSSPSRVPFPSQVQPPLILHYPSDPTVQALGITASGNAIDPYPLNFQFTYSDLSRSRNRARERCDVYDVDVDANDEDQEENGKQMTMSEAVWRKWEQVDWLAKCAGGLFRYAYDRDGNDYRPDMTHVQAIRLVIAASPRKMMTLAQIYQAIEERWPWYKAAGSTWKNSVRHNLSLNDCFTNAERPTHEGGSGKGGYWKVNGKPTGKTARKLKRSLSTQIENEMENDGTESDGGGGRNGLPHPHPYPQLELNANANAHAHLQPSSYFPSSFSPLHSHPHLHTQTHMQRHPPRHKTSDLHTTEMLWDSPDQSVRSVKRYRLSLPPPFTGSGSGSGVVSAPYQPPPQLYPYEHVLLHEHVHEHPHEREGAILTNEFTRSPYPSPFTHLPVYDHAALLHSDIPPSVRISAQSQAQSRGLLSHEPELLNRESYEGRKRERERRVKSSVSPIDVRAQEQERERATEREEQYSIPFVHPSRVNPLSSCSASAPTSVSAPFPRSVTASTSMASKNKFPSEWVYHHTRAAKIGTKGFWKWGLFGTGRGGACGERERERKREREREREREKEQEREHGGYYDPYPTPQTSHEIEGDADHNHHGQNQKAEHGDKDISSSLSPPPQQGAGKMRGRKDAEDSNELQRAADGVELLALAALRYKDEAVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWW1</accession>
    <name>A0ABR3BWW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102259</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615587.1">
        <property type="nucleotide sequence ID" value="XM_066756810.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989117"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="529"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="861" mass="97287" checksum="551E04177CB11659" modified="2025-10-08" version="1">MSSGIKRHYHDDVVSASGRSDKSQESDRKKPRDWREAFLDDSPRREHGREKERDRERPRGSERDYDRERQYRDKRRSYDDRRGGRYDERRQGNGEHRSGQRDRKDYREREPEKGDYSRRYGDRSDRHRDDRNDYRRDVRYNERGESRRSPPTTQPNQVAQPNQVGSSRLVSPPPSRPVQRVSSRPLRSPQGIPKNRLAAPSPGANRSPRSAAQVEGHQKSSMSRFFGAEPEEPDTRPAPSKSSNPSVEPEPIVVEDEQDSANLLEERKRKREEIMAKFKTTSGMPPVPVSPKVVMNDVSVGPGMDSVTSGGTRTGWQTGMQSDRTTATGATPLLKQLGTSSSNLTPIPTHEPSLAPTPMGRDFDLSKQASITDDVAIPTETKTDGVGADMMVSAADYDPTHEGLIDHSKRQKDSETINSHAKEIAEGVGEPVFVEDDESKEDEYEEVEIEVEDDEDDEFDMFAAFGDEQKEKRIKKVVVRRLKNGREAAKQDIIKKPASTIAPEVVDNVDDSDGYYRITPGEILDNGRYQVTITLGKGMFSAVVKAKVLKAFGQERRQDVVGKEVAIKVVRSQESMYMSGRKEAQILQKLNEADPEDKKHILRLERTFEHRGHLCIVTESLSMNLRDVIKRFGKDVGLNMRAVRAYAHQMFLALSLMRKCGIVHADVKPDNILVTENKTTLKVCDLGSAAEITEGEITPYLVSRFYRAPEIILGLPYDTAIDMWSIGCTLYELYTGKILFPGRSNNHMLLLMMELKGKINHRMIKKAAFGTMHFDESLNFISIEKDKITGQDVAKTMVINSASKDLRSRLIPSSSVQLKMKDDELKQLLSLVDLLDKCLQLDPAKRLTPRDALLHPFVAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX07</accession>
    <name>A0ABR3BX07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614820.1">
        <property type="nucleotide sequence ID" value="XM_066757351.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989672"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045516684" description="Alginate lyase domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="5">
        <location>
            <begin position="71"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="470" mass="52482" checksum="06292877D522A4A5" modified="2025-10-08" version="1">MFSLGAFITTTICLLSHLPTALAFGVQNYPNLFFDASAVVSNQWFNGVDSRWAREMSEHWAQTLIHYGPWSVTNKSYTAKSGDKKDYLSWAVYHWPNCSNVQNTTELTQEEVWDQCDYVVRDGQLNPDIELVKDKEALQNMSNSVYLSAMAYLHTNDSQYTTHINHALHTFFINNDTRMNPNLNYAQVIRGPGDQMGRHTGVLDLACMAKIASGVQVMRSVKPAQWQQETETGIMQWASEQLDWLYTSEQGLGELNATNNHGTFAVNQVCALNVLLNQNDACVTALEDFYNGIYMDQITANGDQPLESARTRPYHYRAFNLMALVTNAQFGDFVGLSPSAWERRSAANTTLIDALHYAMLQNYTASNELTQGRALNPVVAAVSAKYGDPDNKYANFLKSADPYFPGQPWFALNEGLSDAGIKQGLLETTYGPVPPQPTLRAGSPDDPGYQRKRDWKPRGTGWPTAAPKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX10</accession>
    <name>A0ABR3BX10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615369.1">
        <property type="nucleotide sequence ID" value="XM_066756592.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988899"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="1">
        <location>
            <begin position="51"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="142" mass="16480" checksum="C9B8DFB5B6F58489" modified="2025-10-08" version="1">MLPSERLYLFRRQQRLTILKAAVHATVHTVQAFVEKQFFCKTALHNNSSTGEYLVDFWLSHSHNEVTRPELGVTVDAFKFILKELKIYASLPLADSKHITAEEQLAIFLWICRPAAGSRKAASRFQHSQDTIQRAFRRFYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX41</accession>
    <name>A0ABR3BX41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615678.1">
        <property type="nucleotide sequence ID" value="XM_066756901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989209"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="80707" checksum="4120AD5D5FD0E15F" modified="2025-10-08" version="1">MANTRPYTREELKSLRRADLQTLYKLHNLKGANGTNATLINTLVEYFTSPAYREAFPQPTGSQTSQVASKATAAPKAERLYKQVPTKPVTSRQVAGMKRNAPDLGTRTGTRIGSGAAGGTRTVSVENIKTAGQRRREQPEAEATSNVEEEVAVDERQESSPLACRPPIPTPQSSLTPQPQQQIPQPPTIGVSEVQALISENDAKWHSRLENVEKRFGDEVERLRKEVREVRLKYEELERLERVRAPRPFPQLPGPSSGPRIPGAAALSQSHHRSVSLPFSNLGKRRLPSEHRSESGDAEVKRVRYNGRVEPSTSISVSGPVTAEASGQPHTPSPRKAPSSFPSDFFAPPATAILPSSSASRAVSLLSRTPSPSRQGVVPDNSQTPRLPFEWRAPEFCSRTGTPLRTPFTIERTPEFATTPEPPVMSMSPSLEGGTLGSRLTPGRTLVHLHGSTPDRSDEDVKAEGSTSASTSGQATSRAGEGISLSAVTELERIDEGEELAPSPPVQHVSPAGQLRFPVIKPHPGLGVGLTGSPSSWSPKLIRRSISQPNQSATSSVVGQHSLLAPPALISRGFRAGSERPAVTSRAFTQSPPPRPRSASAMYRTSYGRSVSAASSRHALPLPSTIIPTETAPQVRSASADYMRIAMFGLEGASLDSVDYADEPLQTDALPDVSDDPAPEDGEPGPSTGVGTSAGVTAERRRWRKVDEVVTPGHRTLLGTERYNDTRFGDIPVGMWAQPNNDFGTPGRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYP5</accession>
    <name>A0ABR3BYP5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615746.1">
        <property type="nucleotide sequence ID" value="XM_066755460.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987755"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="817"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="883"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="833"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0253525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="902" mass="99466" checksum="0AAA2B87F5F75290" modified="2025-10-08" version="1">MSEPPNPTNYNPHGQRGTIPDSSGLVDSKSLSNPVNAGPSNFNNENNNPESDNNKRRRSSPSSEPPRVQLACFYCRTKRVRCSGTKPRCEGCIKADVECEWPAARAKKRTKKEMEEARRAESERNAISAAAVSTSKSNGTSVYKEHVPVFNNEQLQQPDLLNNQSLFWSNPATSTQYLWPPDLSTLPNIESSSDGANQPASNTSQIHQTTSSGQLSIDPNSTAADVQLTSGREMMPSASISMTNDGNPASGQEFQFLTGNEWSPNTDWKIASALEGQPAFISGNPEEGDDLELFYYRFSGSTAIHPGINRVSLKLQRRNPSFSPLATAPQPANESPSTDSSFLGLDLFDDTGMPHSQVWEPLFNLFFKHMSQHFPSCSHQRMMERFQTGTMSQFLACCICSLGARFSDVKDRARAAAPFIARAQELVPPLLHLPTHDVATGLLFLAWSNYGQNSESGLWQYSGMAIRMSSDLGAHEVSELYESPAHYARNQLCFWSLFITDRVVAFATGRPASIPEDIIEIPLPKDEDFFPDPARNLPDSPFEPVEPVPFVQLVKLMVIVGRISNVLNGRRGRALTLISTSEPLPELLAELQLRLITFYANLPDSLKWSANNFKHQHARGHSGTFLTLHLWANAVLALIYHPELLKSPSGVETPLNRSMSRNVQLSLASSRQIVECMVFADLVDSTSYTSSPYLAQPLFVAAMAFIHEMRSLQASIDPPDMPLFPGAASGNNDNSNINNLHPKSHSSNATDMLMLSMAKQNFSTILNAVHKMEEYWAGVNYVATLLEKRSGFPRPSSKASTKTFISLPDKGLLKRFTADPQHPQSVGPPTETSLRDAISRSERASSTNSFGLTPLWLSDFMSGYTVENMSFAPADNVDLERLLASRGEQQDGSKRDTNVPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ15</accession>
    <name>A0ABR3BZ15_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615788.1">
        <property type="nucleotide sequence ID" value="XM_066755502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987798"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0253567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="120" mass="13628" checksum="65F8424BD12FBE9A" modified="2025-10-08" version="1">MGGPNLEIFKFGFYLFTPIYVMLKFGDPEWYNDYVRPYKELFWPPYESTHQPPKTHAAIKDELARMKAERIAKKTAQLSQTEGVETVQGALAAEKQTQGEEGSGETKWNKFGTAGHGRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ94</accession>
    <name>A0ABR3BZ94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2961 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615710.1">
        <property type="nucleotide sequence ID" value="XM_066755424.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987719"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021345">
        <property type="entry name" value="DUF2961"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11175">
        <property type="entry name" value="DUF2961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0253489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="52151" checksum="97670B21CA004FE5" modified="2025-10-08" version="1">MNRTDLLSAGAYRKTARTGRISSWDHSGQNEDAFTVRPGESIILADVEGPGAFTHLWFVQGCRRVLGPGVAPYTVTNCPFMETPRALGLFDEENDSDFYRKVVLKMYWDDQEEPSVLAPLGDFFCISHSMPANFQSLPFTVSVRPMDDHKYGGTSAVNCYLTMPFNKRARVEVENQGENTYIQYFYIDYELYAEPFGKDILYFHAMWKRENPTNGWAPSYMSANTREIQQPKNLDGQGNYVILETEGAGNYLGCNHSVTHLQNVWWGEGDDIIFIDDDSWPPSLHGTGGEDYFSQGWGMQKNAYPFAGTIVHEDDIAQNQVSYRWHMADPIRFNKRIKVTMETGHANHLRDDWSTTAYWYQTLPGPKLFLLPVELRIPRKATISKDDVPEPDMSKATDQQRELVKQREERFKEYLADRQIWIDRRAESSQVRAKKNVEMAQEVRDRWLASLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZG1</accession>
    <name>A0ABR3BZG1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615993.1">
        <property type="nucleotide sequence ID" value="XM_066755707.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988006"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="316" mass="34842" checksum="937E703132FBBD0E" modified="2025-10-08" version="1">MPYISIETIVGGILLFIVILGSQLWPSSMTGNPPATFSSASTTHGELNKKSKKKPKKKLKPQKYTAEGDHNSSPLLSATVTADGASLPDPVKEQADCRLVEDKKDEIFTGRLFHDDREKEISDSTLIEGERERSSSDKQVIKAAACLPELSEDKAEMASAQPHVVTAAVTASATRNDPSPSSSKTSVQKYEDGRLSNDRYLKPLKHQTTGEDDKMWNIVPSKKKRPSSPNITSPFKSDLQATSLPLPVATKGQKKNAKKSEAKKAQRHADEIDRLQRLAKHKKDLERERINELYSGREKRLGGKATVTSNGKLVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZI4</accession>
    <name>A0ABR3BZI4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616019.1">
        <property type="nucleotide sequence ID" value="XM_066755733.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988033"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047443963" description="Ricin B lectin domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="3">
        <location>
            <begin position="27"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="168" mass="18105" checksum="72EFE13A334D95C7" modified="2025-10-08" version="1">MLYFSILLPLLALVSATPFTKRYSGAKIQSYRDGKCLSPNSNDYSNGVQVVTVNCDQAKTWDINPGSGSVILHGTNFALDAGTGADNNEIVKIWTSYPGLFQQTWFLTGDKRIAITGGNQCLDEGDNGPQTYQCTPYNTNQVWNVLDGSGTTSSSSAAPSRTCVTWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZL6</accession>
    <name>A0ABR3BZL6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616044.1">
        <property type="nucleotide sequence ID" value="XM_066755758.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988059"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0253823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="76" mass="7920" checksum="738408448E8B4243" modified="2025-10-08" version="1">MSYTIAGRAIKNEYLALGTIISTIGIAVASSGGSDKAAASSAPVSVSDDKTITGETPEEEDFIRQFVAEAEKSEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0D9</accession>
    <name>A0ABR3C0D9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616067.1">
        <property type="nucleotide sequence ID" value="XM_066755781.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988082"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="480" mass="49655" checksum="F69D67D58659E7A9" modified="2025-10-08" version="1">MQVIGNTPPSSFLDTEGLTLFPSTSAPEGTSAKFTSEALSETVSGSPSSAIITSAAEITSATAAAVTSASEIINDCPDESSAVVTSAEPYVTSIPQGSPTTLELHDCADESESIFHSGSLVASVTVTSAAPAATSNSASDGIECPDESGSVSLDVSVTSKIGAGAFASVTDGSQTFIPASASVSSTKGSSESVTASAAVTDQPASASASSSAPASSSASASTPASPSSSSSSTPTSAIVGSDGLARCTDYKCNSGADWLVSALCAISKCNHMWPLSLVSDIQGDLYHTTRASFTVWSRLFQPVTSVITFDEANTALADNSAEGGWLGGALDVAIENMGGDGVYNTTDGERGYKGKMLMSSKTETDRTRVEEAGVWGLVYLTGKDAVRESIPDDDATWLNFMQKVDGSPVLIYTTDTPDSSLAKDQYYTVSTITNNSNVTLWDPYGDGMDAYKYIDISALKVSSKWIYHLDWPHFFWPNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0N5</accession>
    <name>A0ABR3C0N5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616172.1">
        <property type="nucleotide sequence ID" value="XM_066755886.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988188"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="899"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="463"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="585"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="657"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="745"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1147"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1264"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="764"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="797"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="826"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="861"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1195"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1231"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1297"/>
            <end position="1309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1473" mass="157462" checksum="7978D87881B2D0AA" modified="2025-10-08" version="1">MSQNTSSTVNSDNKTSASGSIASVWARGPPSAVSSTSASRNQSGVNTPSQDGAGPSNITDVSNSAAISIRNAHSRQNSLLVGPGGVDIKKGNIAFGTVDSPTTALSSSPAAPSTTGGHLADAVKSFGSIDADGNTDPDVVKTRRTSALSNSIGPVPEKKLSVHSLFTSKAPAQAPLGSSPSRPAMSPPQPQQQPVPHIRRQSMGQGGPGFQGQVPMGSPNFTSGPPMRPPIVMPNQPRSPVANPNMPHGQYSSMPPLHVQQGFRPPQQGMMSQQPPVRPGGMGTQGVARPMMGPGQYGMHPGPQGPQYPVMGYPPQGGFYPGYGPYDQQPHYGSPQWASQQQNQSFNGNFGPGPMSPRNAPSQISSAPSQSPLPPQGVPLGSSGPSPIPTPPNRPPNLMAGHQHSASIPTTPVPSTPSRSMQANVPSPFLSGAASVFTPRGASKAVKIAREDGTAVNMKEVAEAASKAVSSGGHTPETAAQHTKDEAPRRKPGLPVIVRLESEEQKKKRVAEEEREAKLKSVEEKEEQERRERLEKKIKEDEERQAKEAAEKAETEKRAKEEEEKKRLDEAYAAEALAAKKLAEEKEATAKAAKEQTEAAEREKLAAHAATQEARDKADEQRRELLSTPVTPIAVSPMGSPALGAGLPAKPIAAISSAKRTLSTAPELASTSVATPNETPSASASALSSARPIDDLSSITYPATLKSPDPRLNVDAEPGKFRYDREFLMQFMAVCREKPDTLPPLEDIGLEVDGGSGFGGRSSRGGNRSSMGPSSRSAPGGAGLGISGSNRSAFPGQGMGQFGSMGQFGSGAGSIRSTSEQRYRASLSNRTSSSLSGLPSLGVSGSRTGTNRGSQRGTKRAPQSSQAQTSSAAPIPISENAWTRTRLGGDAQGTPAYIERKVKALLNKLTEEKFDPISGQILEWANKSADETDGLTLKLVIKLIFEKATDEAHWSAMYAKLFAGRALFRRYLLGRCQVDFEAGWKAREDTAVAAAAKKEEDGAKQEEAKDDKDNEAVLMSDEYYAAQKAKRRGLGLVQLIGELFKREMISNRVIKECLLKLLSNTTDPDEEDIESACKLLTTIGAAYDRVAPENLSKAFDMLSKMMQMESLSSRIKFMIMDVFDLRKNGWKSKKNQTSVMTIAQIHEQNAKEKSAAATVTKDFISRGGSRSGRDRHEGSQPGEWQSVSAGPRSLNRPTDFSNMGRNISSGGTAPSFGPTSIFNSRKGKAGTPTNITPPMSRQPSSANMFSALNDTQENDIISAERRTSTDNGESAPQRKRLNLAPRTKPIEDEGESKDEGAGEEVHGDSIDDQGLSEEEAKAKIDLDMKELWGEKDQGGSRNPEDIADYFSALPVSHRPLLAERLLNDIFRISRLKDAEIVAKGWKIALLQQSVSADVLRQSLEHRMPTLDDESIDFPSAYEAVALLFRNVSLSQEDINAMVGRIEVEGTPRITPPQKMEKAIRKVDEAGSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0P2</accession>
    <name>A0ABR3C0P2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616416.1">
        <property type="nucleotide sequence ID" value="XM_066756130.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988433"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0254195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="89" mass="9426" checksum="ABA6C603BF249A7B" modified="2025-10-08" version="1">MSNFQRLVPAFLAVTAGIATGYYVVAPEYAPGGAGAEVIPPEQRKNTPVPPISSSSAFDKVSPPMTANAGQRDLLEDKAVSTDSIIYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1N8</accession>
    <name>A0ABR3C1N8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615907.1">
        <property type="nucleotide sequence ID" value="XM_066755621.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987920"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36198" checksum="54FAB8105C081F8B" modified="2025-10-08" version="1">MPPRKPQTLQSLLPPILSLLPNTYSAHQKALTTTARLLHASPPEYGLAIEILFAVAKELLKTGEAGSGSELGVRMLTVMGEAGIEVNESSRANVTQLLALTSATGPWRKKLVDSAVKWTQAHGECPSGDPHLQQYIGEMYYKERQYFLAEQHLLASGKRDASIVLADMMFEWCEKGALDPGPFALRGILPPLLHSPPSIVPAFTFLTTFLAHLTSPSSVFHASLASSIPSQTSFSLPEIIVTASQSLNFAQLALVTIQHAPAKGVSGVHAGGTDGGIAREWKALCARYSKTSPVVAQPEVQEALSQIATEVFLIPRPRGSGNNDLLQNLMGSLFGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C2M4</accession>
    <name>A0ABR3C2M4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616237.1">
        <property type="nucleotide sequence ID" value="XM_066755951.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988253"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046500925" evidence="3">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="201" mass="21961" checksum="908A566DCA6948E5" modified="2025-10-08" version="1">MFVIQLLTVALLLGTRSASAATCYNRWGQPYYCNNGLSWGARLGIGLGIAFGVILLFALCGYWRRRNLRSQFAKYKPPSLPFTGHNQDQNPYANNPPPPSGFNNNPYGNNPAPPPQTYQPSMAGQYGSYQGQTEGDENHEHGYEWEQARQEEEERRKQGGQTSDIPPPGYDVATSAQNTGSNAATYAPPPGPPPGKREGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3D5</accession>
    <name>A0ABR3C3D5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Oligosaccharyltransferase complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101622</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616462.1">
        <property type="nucleotide sequence ID" value="XM_066756176.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988480"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046342302" description="Oligosaccharyltransferase complex subunit gamma" evidence="10">
        <location>
            <begin position="20"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0254241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35440" checksum="F27A79FEC31130B2" modified="2025-10-08" version="1">MRFTSLLAAVPFLSSLALAADPAHWSKLAAKSRDGVVKLDSKTYEDILALDREYSVTVLLTAIPAQYKCQPCQVFDPSFSQVADSWARLPKSQRDQHFFARLDFADGQAIFNQLGLTSAPTVMYHPPLAGPRRSNKLSVINYDVNRNGLSAPPFHSWASGLTPSPFELHTPLNPWPFIFVPLSLIAIAVSVYSLRSILVPLIQSRVVWGTASIILILTFTSGYMWNKIKGTPYVAAGRDGKVQWIAGGYQNQLGLESQVVGAIYGLLAFSIVALSVLVPAQTSAVKQRIGVYLWLGMLVVVFSLLMKLFRMKNGGYPFSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3I2</accession>
    <name>A0ABR3C3I2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100004</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616486.1">
        <property type="nucleotide sequence ID" value="XM_066754585.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986862"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="5">
        <location>
            <begin position="26"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="377" mass="41743" checksum="804B376408F0F039" modified="2025-10-08" version="1">MDKVDALLGPLNPNKMAAKSAPDPLKVLVLDATGDEGFSVCKSMLKDGGFHIWGLVPNADTPVARELNRLQVRIVEGELNRPDTFQNQLTGMDGIFIPSDIFSSTESVACGRSLIDMCKAAGVGHIVFTALDLVPNGEGSDHPGGQILTYIKQTYTGHAEHGDRPHGAHHHLHWTILYPGWKFSKLITLDLFSKVPTSELPARSRKLNPAKELDNKVSRKEGEQASSVADDDGEEWLLRVPLPDETSFPGYAVEQLGLWVKAAFLSHKKFRESIIQVCSTMITPLQMADILSKVARKPVRTLGLTLEEFFSEGFKTDMGETKWERYRAAAEGHFERDPEASGKVVPEQWNFAQWAGQSKELAALFKENNDQPEGKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3P2</accession>
    <name>A0ABR3C3P2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromatin modification-related protein EAF7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616520.1">
        <property type="nucleotide sequence ID" value="XM_066754619.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986898"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35337" checksum="8D0BC11EF2D36E4B" modified="2025-10-08" version="1">MSSTAATASVSPTRRALSPAPAVTDLDLEIAMLRCLGEIRPLGRYKHFLIIQLQTEIHRRTGSWLPIDLLWQRLDELYDLEGLDEMASSSSVSIPSTPHTLSPRFPLSPQSSISSLSDVAPQKAKSSKARNPNNKATSKANNKRGKSPGISKSARIINSEHFHRTFDLPYFKSRYHLAEGEEERCQEDLEDESDSDEPRELDGEEERIWQDMIYSRALAPDGTDDSWGGDSLAIDEDESDDEDMKPKDKRKGKRTSAMSIVSRRESAGSGAGGEKDGGKRGKQTRAQEESEEDSPSPVKRKGARESNGADVKKPKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C443</accession>
    <name>A0ABR3C443_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616659.1">
        <property type="nucleotide sequence ID" value="XM_066754758.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987044"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="246" mass="28624" checksum="4D7B2C3660477CCB" modified="2025-10-08" version="1">MPGPKPNPTNTLPQAYKLVHQILSSAKSGLHTKDIVKQGVALYADRLPPHAFEIEEPVDERKHKGKKRHIPEPKLVPQGHPFISTSFLKNHVLPTLQSQNLIHKHVVHLDDSESAPSTPSKRGNAKRQFVWSLRDLPDVESQSTSWSYSEHWQRLLSGAHPEEVGAEHKHFLEQLKKDERRQAIESGAERRTEEEIWAWEDRKVGVTTEKERGHLNKRRELKRPQKEWKRYGRWQQLFRDQETATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C499</accession>
    <name>A0ABR3C499_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="9">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lipoate synthase</fullName>
            <shortName evidence="9">LS</shortName>
            <shortName evidence="9">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_100266</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="9"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616739.1">
        <property type="nucleotide sequence ID" value="XM_066754838.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987124"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="122"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0255462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="396" mass="43062" checksum="78915F6DB7FD8D87" modified="2025-10-08" version="1">MVKLPSAARIRSLATAPATATRAFATVNPTSPASQPAKSNRRFEKLDDGLTFDDFLSGEVPPENERVVLGNTKQPRLPSFLKHPIATGASYSGIKKELRGLGLHTVCEEAKCPNIGECWGGGKGNATATIMLMGDQCTRGCRFCSVKTSKTPPPLDVHEPENTAEAISRWGLGYIVLTSVDRDDLVDGGAAHIASTISKIKQKAPNILVEALTPDFATKGVEVIHTVAASGLDVFAHNVETVERCTPFVRDRRAGFSQSLKVLEEAKKGARAAGREILTKSSIMLGVGEMEEEIHETLRRLRESDVDVVTFGQYMRPTKRHMKVDRYVEPEEFAKWKEVAEGMGFLYVASGPLVRSSYKAGEFFIENVLKKRRAAAAEHAASQLSTQPPSEVAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4J8</accession>
    <name>A0ABR3C4J8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616820.1">
        <property type="nucleotide sequence ID" value="XM_066754919.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987206"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028018">
        <property type="entry name" value="DUF4646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15496">
        <property type="entry name" value="DUF4646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1132" mass="122464" checksum="47DB702DDDE90A96" modified="2025-10-08" version="1">MTKTNTPPPPSALHSYEPPTEIASHPPSQRHHHDHEHHHHHSHYVRSVKSSGTLKEAIQEKHLDGFKGEETVEAQAKVVSEPSVPPIIASAKASTKTKNTSIAASVKTSSAAVATSHITRRKSILATTSAPAQVVGVVPAVASAPATIVPSVAPSVATLPTNVKASSKTPSAKAVSGPRTVKEPSLRAPSPTPSHRSRYSHHHPEVIVNVTIPQAIAAPAPLPPPVLNPDPSIPIVIEGTVKEALEKAVEDVPATPLVVPVTPHHASKTASIPAVPPSPSPSTRSRLSRLQSAKATTVPLPPVAPIAEEQGVEEEPEERVVEETRVVTTTRTIKRRPASPPKVLESGSHYVENILEDEEPTPPPSTKPKSSVQSNPQIPPLPSPVSSAPNTPVTMKCHLFNSKPSLPPKIRNVETTTVESISYPLLPQQSIEETDVNTAASTAGGPTTEGIGGARSVALTASSGRMSWTKAGIHPIPMVDYKGLMKRSPAPSQKKPLPPLTGAATPPVRVPTTTDEVTTTSAAQAMPLPATTAAMTAPASNTASPTTIALEATPTPTSPRTIMTLSAQLGRDSHGNEHVHARWRDHTNVDKVNEPDAAGHVETTELPVETDKERRRRTKRETKERKKRDKLTSSPPYRPIGALPPPISERYACPPAPTEIGRQAKQRLGEKMGRGGPTLPLPLPLPRPQLFPRPPPLVGVRRPIIPHQMFNPMMFNPMMSGYPIGTMGMPMGMGMPMAGPMPGIMPGMPGVGNLPRGWFGRDQLGRDFAGPGGVGSSQPYRPPDPSALPPMPFGLPFIARPGQEGFDQYGRMLPPALPEGWDGWGRPIVAAGVNPPAPPPQPPQEPPAPLPQPQTHDTPLAAQPSGMGGSTYGYPTQFGSQTSTLMSKTATGRPDQPPCFDRPPAQQDSYYRYEPFEAFSISANLLNHPHQLHLPPELVSRDVNEQDWMKFIEDLSREALHGASHSLTRQARGEHTGPDPLLSEAVHSLLASWAVAFFAPRGIRVYVAQNGKKIIPPPIEPPHSKRGYSHASEWSDSESASDDDFGYGTEDDEEREARKSDMYLPKREREIRRSERIRMRKWERRRRMRESELKNGEYRGAWEIHFVPATPTIWQLGTRPRTYGEPVVKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4R6</accession>
    <name>A0ABR3C4R6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase substrate phosphoprotein PP28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616761.1">
        <property type="nucleotide sequence ID" value="XM_066754860.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987146"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="140"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="220" mass="24143" checksum="9A9BC45CAEE3CF54" modified="2025-10-08" version="1">MGRGGGVSSRGRGKFKVARGGGRHFSRDLDPRFNKPVSESSEEESSEEEEESSEEDETIQNQQLAPEMAALNLKLGNTVALDDDEDQEAGMSRAERKAMKKAQGQKKVVTIQEPEDSGSESDEEEVVPAPAPKGKGKPAKKVEPVQMSRKEREAAEKKAAEQRYQNLHAQGKTAEAKSDLARLQEVRARREAAAAQRKAEAEERAQEAAAKKEKMLAKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5B3</accession>
    <name>A0ABR3C5B3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="2 8">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="2 8"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617083.1">
        <property type="nucleotide sequence ID" value="XM_066755182.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987473"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="413" mass="46797" checksum="CA2152C136531998" modified="2025-10-08" version="1">MKDGAYHRPAASPDPCADTQPSDWTYIAEGGAHIVFSYRGRSEAYATRALRVRKPSATTEPLVQAEENDACDRWRRNILPQLLPWQLLTTFSEVILEEWWYNELLAMADVVRPARRKLATDLTAKGNRTGVLLEDLTSSEDANGAIAVAIEIKPKWGFLPCARHLQPPESVSIKSHVSRFRLHQHFRGHSDDPPYDPLDLFSGDKMRMRTAVDGLWTMWEISRGKNNNWKVFIGGKEISPEDLQRDLLPIGRDDFVTNITQITLDALQSSVALPLLKNLQQNLDPIDISSLAAIFQAEHPNSPLFDPDLISDISAAELDSFVDIYISDPQAGERMNNWSLRERIIAYALSAIFKDCSLFIRGTVKENGTWRLISGSESLKVIDLDLKPIKNMQKWAKTDENVWKYWLKTKGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5F3</accession>
    <name>A0ABR3C5F3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Xeroderma pigmentosum group C-complementing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617127.1">
        <property type="nucleotide sequence ID" value="XM_066755226.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987517"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.290">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="552"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="604"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="673"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="790"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="892"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="892"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="909"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="980" mass="109415" checksum="341687A648500EF7" modified="2025-10-08" version="1">MSASRPKSSRVIQKPRGISALAARIPSSSKQQASVSGKRKTATPATHKGTRPASPISVASTVLTVSDNDEDDEDEDEFEEVPIPISSGEVQEGDEDEEEEDDARVIHLEIGGETAEDKAKRMLLAKRKKPLTARDRALRLEVHKVHVVALLASASIRNKWCNNSLLKARLLSLLPHPLQAAFNIPPSRFPDRAQRSRLFFEALQSLVTWWSQTFFDVSDYAMGLRTRPWDEVQGIIESTSKAHAPFSRSSSPHGDGKMSNKAANKGKGKAVPSEELSEQLAFGSGAERLRSVNSLMKKALQQEGSRDVSAQLFVALARACGLGVRLVTSLQAVPWRAEKVATKKKAVGAGRGGRTLASRQGLGDGDEDDDEDEMEEVLIPDDQGKYVGVAKNNTRGAGSRRLEDPADLYRLRKYKPPPRKLGSPAKSKPRASQSLADQPPVFWAEVFNRSDQRWIPIDPVRGIIRKKSGYEPPTDSGPVRMLYVVAFEEDGYARDVTLRYTKNFYAKTSKLRVPTKPNEPQWWSDIVMGFLQRPQHLNRDDMEDAELEMSQMTEGMPMHMSGFKDHPIYVLERHLKRDQVLNTARPVGRFKGEAVYRRSSVQNCKTAENWMRSGRKIKEGQEPLKWVKQRAVTLQKRRAQELAKQEGEEVTQGLYAEWQTEIYRPPPIKDGIIPRNSFGNIDLYAPTMLPLGAVHLPYKGIAKVAKSLGVSYAEACTGFEFKKQRAVPVIKGIVVAAEKKQEVLEAYEESTVAAEERERMKREDRALKRWAKLVNGLRLRLRLQQEYGSKDKVNGSSNTGDEGEIQVNPPGKTAAEILAAAQRKSTRDWEERVRREDINMDEEDDMTPAMAIEREPYQIPLDDSSVPNNVVSEINNIPSSSETPRIMLRFKNTSSPQSAVQAASESRNRRTPSRKRKTMISETIEAVDNGQFGDPQTTKGSIDGGKEIVLSEPVASAANGRTLRSTRARTREQMKANQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5Q1</accession>
    <name>A0ABR3C5Q1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617225.1">
        <property type="nucleotide sequence ID" value="XM_066755324.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987617"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045123114" evidence="3">
        <location>
            <begin position="20"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="654" mass="69982" checksum="0555754E48B793BA" modified="2025-10-08" version="1">MRAVCLIASFALLIPLSAAETSTPNTGDQIQAFQFAFSTSSLVLPIVDTCPTPLTVTKVSSTNAQISDPSAPYTLVALVHEQLYDEAGTQYERLYSASLDMGDMSAEQTIFHPWGNGTQFIACMWAANGVSGGCQDLYTVVPSHFTAEAYEDKSSTCRTPDVLGSWVTPSSQTLDVTIEGASGEIATNAWPPACSDLQFTPNNGTAPYTLIIAPASHPPVNITTVDGASVNYTVRVTHGQAFMAAMFDSEGNSWVYGPMHSGESDDLSCLAVATGQEESKAKRGYSVAILAGSTTAAFVVGAVGASLVMWCLSRKTGPMMSPSTEDLYANPRPAASYRTSSGSIFGKPLNANSTLDFDTPSTLYDPHLSGPYGSYPQPKASPNVNRECPNSASASSRDRAFPRSPVGQDDAGEYINSYDSPSGYRDSITLADFGSLGKQANENTSRSPTHMGRTGSGDISSHMQETSWNSRRSIPLPLTIQSPVSPSGTHRRYTSFSPRSDSYHSLHSPGAEDSGSPPVTGATTTPRMRNVYVVHSDAGDADVTIQLPEGRNHVVELPPTYRETSSPSSARDNYNNSDHSPTLSGRESMPSMLPLLQRRGSSWESDMAPRPPPLNALQLTRTRVSELSTRSGMGEEELRARAEAAMKEKERLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5V3</accession>
    <name>A0ABR3C5V3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616998.1">
        <property type="nucleotide sequence ID" value="XM_066755097.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987386"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="837" mass="95290" checksum="0E974139E4F05C81" modified="2025-10-08" version="1">MSRQLLAWETEERKLQSVYGAEESDVLQVYKQIQALAGPKKEMTGRGVWWCTLTLRNMGRLDLAQQVYQDLYDLHPETYQLLEQLFFHSAAAWDVSTMVTSSRKMFNATRDPKWARLAAWAEWVQKAPQPTPSDPFPCPASPNSLKIAQVLLSTTGNTCDTSEIFWLRAQILLSSDQPGDLLKLARQQAQEGSLARLWWRMETVEIAMARCGKEGQKEWETERKWVAEMLEKDNGSQRNYAFYQYLLLATQNSTDPDSVQSTVALLKSLTEQIRQKERAPQLAQLEFDIVLHNTKIASEMDISSNLMNDDEWLDQVEQYWNLWGSKGSIATELIAISRGSEKRKAMVVSFLKARAAQQHHDETSFKEVSNAHTILLMEKDADWMPTDEDIEKYWRLYLEGLRYGVNLAKTDVQSSDSIGLLTVNLLLLMWHSSPKNMVPLYKSILCLEKICRQSPICMHAHYLLIRLYRLIGAASLIGPHLTALGLSEIQLDNLLHIAVERGAIEALVTKNVGIWLSHTDKAVNMYQRTASDFPEYVKECLSNETYSKITSIRHLASSLRDSLSSHVLAIEQARLHVFNSPTVPFPPQLTRRLQKSLKAEVIDLRNWDLIQEISGKRKLTKDITELGGQPIEDSWVKTMGRFWLAVGEFIKSGEVVDLELEDLDALLDHERALVECGYIVLKAAFKALKPSAEIAESEEQQKSLKGIFSENIRICCGVHDSRWSLIQSCISLAQLIKITDLVFSRAAEAAKPVKGKKKPTQLSAFIADLRNEIQDFKTSIVELNSRLDAVRSEDEVKWDCLNSLFHEDVYLQDIFDNLINARKAFLDDLKPLLSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5Y9</accession>
    <name>A0ABR3C5Y9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1479-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617324.1">
        <property type="nucleotide sequence ID" value="XM_066755423.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987718"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0256047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37056" checksum="388A27317F51A2D0" modified="2025-10-08" version="1">MKGFPAAAEKKVVYESYWSPSQVKARSHPNMLATQAWMNQRYHADPKQQVDLSIPLSYCDRVQIRPPGDTQFALSPHVDGGGVERWEDKAYNHVYRKIFEGKWREYDPWDLSGRLEANMNMYNGPGGCSVFRTFQGWLGLSEHGPQQGTLVVHPILSPSTSYWMLRPFFKPTVKGSLDGWKFSLDDNDGNIFLHGANPGTAQEHNPDLHPHLHLAETMIPYPTVEPGDTVFWSADTIHGTENNNTGDVDACVFYIPAVPTTPNNVQYIAQQRDAFLHGVPPPDFPGGAGESQFSDRATPKDIQSEAGKFAMGLKPLEASKGALAKSINSILGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C679</accession>
    <name>A0ABR3C679_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoporin Nup82</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617118.1">
        <property type="nucleotide sequence ID" value="XM_066755217.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987508"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019321">
        <property type="entry name" value="Nucleoporin_Nup88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10168">
        <property type="entry name" value="Nup88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="850" mass="92837" checksum="7C9BF7E96618E187" modified="2025-10-08" version="1">MSHTIPLSFATLKSHSIFIPPISTSSPPEDEWELLDRSSADEPMSQKHSRMVMRDKDLIVAVDSEVRMTSLHASDGSWKIEDGLVGSYRTLKSPHLTFAIHHIVVNPTGRLLAVVGHHQIVVLVLPKPIYSGKLEDGQVEVESIPIDDFLFSRSSDDAVTQVQWHRWGENGNSLWVLTASGKLREYDVLQPHDCVQTFDFIPERSRSVPKFTAVDPLSRYASSFAFGASMIGFSPLMVYCLLASGDIHVLGPILPLRTEMPAQYLRELKTFMDIRLATVQNQARDVFGAGTSGLGKTVLQAEWVDHLVKQVRQTEEIQSKKQVEEGGGTTRHTPMGVTISGKLTKSYSYSAEVGSSSLGLPRNGFVRIHPPHLTESGGPAPGAHRALLRQGPVVFSPGPQDVGNVDEDLDEEQMATDLLIMQVDADNTEAGGSKKTEGQTVIAIAWSGGRVDIGLELDAPEARWVSSRDPTPPPPMIHITDSILLSFPNSDPFIISSNAPVLARDPLYSDVFYVSHAFGVDAINVRPVVDGLDGDGNEGELPPPEVLRLVESNGVPNTPIVGLFSFCNITFGYGIVALASTGQVAYVELDIRFGDPLALLSGTARAANGFETELKDTQSLLDNVFDADSLVSSVKTGSKALSRQIPDYSMPLTVINSDHLSALQDISSHVHAQAQRIRAASQTVENRLDLQVQELQLHARLLAQCRQDVSDLQKSETLDRIESLIRRQEGIQKRVEKMLAILALGYKPLVGYGERRLFKELEEMAMKLNGDSEKAEETLTDKAQSLQNQLALLLPAVSKAHQMESAAAATLAPKQIKPLKAALGARSEELKRLLNKIEALDISLDTASVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6Y2</accession>
    <name>A0ABR3C6Y2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616541.1">
        <property type="nucleotide sequence ID" value="XM_066754640.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986919"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="69" mass="8127" checksum="84E17EF2CA4C3A6F" modified="2025-10-08" version="1">MKDSRDDLSLVTYTDRDHYPERSRIMKRLWHGTAHSSVPCAKYTDDVLEFVLRWSKRLTTLFSTVHSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C922</accession>
    <name>A0ABR3C922_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617261.1">
        <property type="nucleotide sequence ID" value="XM_066755360.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987653"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1179" mass="130706" checksum="CFE8969B74673DED" modified="2025-10-08" version="1">MAAIHSSAEAAREGINEVQVQISKDKSRGWQKRAQKWAKGRKLLEKLLDDSTLGSEASLLTAWVEDEFETATSCTDISLTIALLVHLVKHVYETFIEPSSFSIKGSRTLKMTCENQTDQLGVLHFAGTIIVSLTELLLTHEMLNHHHVAFHVDLFIRLMEACIEGKIVHAQAHMNLGELLFSIVSNMENSECCTSEDSALGFANTGKLIWKSQSSSITLCLLSILQSLLPAHAAAKDSPRTLACRKVVMNQGWSKDIIKESFSAIGKMDRKLYPDHLMKCINIFAQDRTILRPKAFQLTSLTIDDENQITSCKSKKDLKDGHLALYVDRYCCRFTLYGNDGHESPRIFGHTEVEDFTRLDTKDGESTGFKFQTPSFDDHMSVVKFDIKTDEASDLETMLESVKDQIPQAFKREAEKQASATTAGQLDPPAPAAKAEDKRKARFSSLSRSISPRINTNETSGLQPGPKAYATEFARPYKVRVPVDAVDEEDSMPTRQGVVKESEGDEMTQKAGKGGKMGKIKVEKPEWKTVESDADADWDEGGVSLIGKMSTPMTRSTKIYGSRGSRSSSSRRPMQSRLSPLAMESSDSELDVKPLSPPISNRRTSLFQNRSKKKDIDKRNKATPTIRASALKSRTKSLASSIAEGRAATPVSRGGTPVIGGTKEEPFGATGGNVGGDGKVAMGKSGRVKKDKIAEKALAFSSITALIPEPSPTSRRALTKKPFSQQTFDEDREQPPEAEPWTKVGRKTLQSQTQSKLKDQEPSIPPAKESQSDNEPLKKRAITRRDLDCDLMAEGEAEKPQNKLAKKTTRKSTIKVTTSLQEKRVRAVPIRGPGPTLRPEEYHSQGSRLNQRDVIDLPFLVTVKGVTNPRRSKANKMIAQFDDEDDDEQVQELGEEDDEEPQAKERGVRPTRGTAGQDNGRNKKQKQISRSQPDGSNPHSNSDLSSDSDHPPTKRDKASSKRKTETMTNSKATKAEPKAQSKARKNKSYRLESSEDEEASADNQTSEPHSDLTSDSDPEEHVKRGIKLTTAPKLLTATVSSRSTKTKAQTKQISSSGRPSISSRPSKKCKRTSENESEGEDEEEENKKPPPKRTKKAQSSVKRKRDDTPDREEESETSQPSPKLVKATRKSPGKTMKRGKMENKKEEMKAEEEPLKISDLLSGISKAMRKRVNTRSRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHR9</accession>
    <name>A0ABR3BHR9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610761.1">
        <property type="nucleotide sequence ID" value="XM_066761221.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993656"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="188" mass="21532" checksum="697E3E1C8A565EF9" modified="2025-10-08" version="1">MSNPQSPEFFELSERHPQSSPTPRAHPASTGTVQSVDRALAVVTGPETEEPTMAQHEKETHAQINEEYTEFDPMAEIGRFNCKTELEDKWDEIQGEMVPFLREFAEQAIASTYDVILHVHYIFHQLDLRTQQSLIEGVEAIEEEEHRQEEARKVMIDFSNEMKRAAEVLKQFGSATTSSLLREKNISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI94</accession>
    <name>A0ABR3BI94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610917.1">
        <property type="nucleotide sequence ID" value="XM_066761092.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993525"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43880" checksum="51068D1CECB26B2E" modified="2025-10-08" version="1">MSSAFHNAMVFAAKRESITKQHVIPPRPSQPPLPNIQLTTLAPLHSIHHLIFVYLEELCPALLLRVSPSFHKKILPKLYTRVVLNSDNAPGFFHGVTDGPNGRKAKSLQLVKTLVFSDPEAMETIMREVYQPPIPRGLDTFWHARPDITYPLFPYTTNVQIGWPILRFFLTPPHHIDGFPDDSREGLAPSGGLSAMMIYAMSFSSMLEDQVPEMKKLCVDLESGETYDGISVEQVFRTIAYRGRRQWVNSIQRRSPGKMFDFTLLIRVHLQPQQTPVYLPAKTPAPFVIRLMPHADPSKRLPVDPKVTAYAIYNLFRIHTSRDSVPAVFEVIEEQSVRRELEKVIEDLGMRRDTTTWDYFWKSFELREKGKEKDDWEPPAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIY5</accession>
    <name>A0ABR3BIY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611151.1">
        <property type="nucleotide sequence ID" value="XM_066760879.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993305"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="86"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="373" mass="41318" checksum="94459A57FAD265F0" modified="2025-10-08" version="1">MAESMDIDTPIPSPASVVPPRNAMAALMSNAKGKGKEIASTAADQKAVDDKEGLPWVEKYRPVSLDDVVSHKDITGTIEKFIEAGRLPHLLFYGPPGTGKTSTVLALARRLYGSAYKKHILELNASDDRGIDVVREQIKNFAMTKVLFSKGFKLVILDEADMMTQAAQSALRRVIEQHTKNVRFCILCNYVNKITPAIQSRCTRFRFSPLPEKEIQVKVDEVVQKEGVNLTEDGRDALLKLSRGDMRRALNVLQACHAAYDIVDETAVYNCTGNPHPRDIERVVQSMMADEFGTAYSLITSLKIEKGLALQDLIAGAYEFLDTVELPKQSRIYLLDHLGSTEHRLSLGGSEKMQLTALLGAFKVAVELSQRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJA4</accession>
    <name>A0ABR3BJA4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610858.1">
        <property type="nucleotide sequence ID" value="XM_066761033.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993465"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="GmrSD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639:SF1">
        <property type="entry name" value="DUF262 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="GmrSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GmrSD restriction endonucleases N-terminal" evidence="2">
        <location>
            <begin position="65"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="414" mass="47623" checksum="BDA29497ABE2B50C" modified="2025-10-08" version="1">MPEAYPPSPGDSDSLLDELASYGSRTPSPQPGEDDPAALQEYIHKITKGELEAPVHQVMDTRKLYDLIKSEYIDLSPDYQRDVVWTSSKMICLIQSVMLKYYVPPLIFSHNNLRLMNEKMVCIDGKQRCTSIVRFMDGEIPFVSPETKEKLWFKDGPGKRKLLPMPLRRHFEQVNLPAVTYKELGEEQQRDIFQRVQLGVALSSAEKLQAISSPWAHWCSKLEKKYITAPNTLGDLLSWDIKRAKSFQNVVGFVYLAKCKVEGKEAISTGWMPLKGLLEANVPLDPHLMDEAEMAMSIWLVIAQRYYATAFDTVSKRVAPIESWFIPFFILVHMHRLSYSQLAQTIGDMRRELHDVFVGNVFANTKVSRWLLDWINRVESVKKRGLETAEEQWKREKAAQNQAEGEGKKRRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJA7</accession>
    <name>A0ABR3BJA7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610873.1">
        <property type="nucleotide sequence ID" value="XM_066761048.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993480"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="198" mass="21776" checksum="A6834046E2066E23" modified="2025-10-08" version="1">MTRTERNQYPAAVLKDRHSRTGLDKTQWNHKNGDGAHNWGSTARKGEDEATGRMDGEAEAEAALDEMPSSEVFDLDEEINDPVGAMPVTDAGNDFKPMDLRKRGSIEGQSNVATSPTDSMSSMDNGDRPGMGRRMSAVSDEEREQMRLYREGVLHNKQGVDLAHIARSSHGIAMSPPTNSYLGTVSPSNTRYGFNFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJP9</accession>
    <name>A0ABR3BJP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611397.1">
        <property type="nucleotide sequence ID" value="XM_066760636.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993044"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="44"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="542"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0242015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="768" mass="84506" checksum="693114161C59DF20" modified="2025-10-08" version="1">MRGRKLQNPVPASFPGNTNGRGSDEKQWEACRDILRRVYGAKAGSRRLSNIFQEFPDRGEFPDYYKAIPEPECLDHIAAQLASQAYPNPETFFKQLHLVFLNAKHFQPGRKRARGSSALSTKSATPGPSTEVQSLSPIVEPIPIPTLAKVPSALPFPSSIPTPTPAALNRPSLSRPTHQSLPTASPSITLTLNQAYSAGQSTTLSDRTRMAPRDADQAIIAARDATLPKWEGPKEVLPGNPAPGGIPGSGWFGEGTADYERNIGGPEQWSQKIREVLRAVEGYRDYSGQRLAEVLDILPEVHPLSFARINAIADASRYPSLRDFDMDMVRLFEKARRWFHDGSEEYGRVLVLQRLYNALTSIYPLQLPPSGIPEPSSIAFASIPAGPGNARSMHEATQELRAGAAEEQVGYGITTFRVGTKDRVFTEEARHKGMAYRLDDPTRPIIGQIFKTFVPTKGKQTHHASICWYYRPEQFNSTSSTSVGGQEKENSIRDGLFVSRVLVSFTDKQICIPEELRQTDFMSIIPFERVIEARMVPSPLSQGVQGPGFFGEPKKILGGSAAQDDDDDDEEDKGRRRGRSSVHSAAHTPAPQNQPRAQPPAAVYRASPAVAPPPQPQAAPVVVPAPQLPIAQPVLVQQPIRTFAALMGGQQALDQVAHRETLPAETARLFPTDARGQVLWFSGPPLAPGAIQIPQQPVHSVEYLQYLTKRKRGEEWTPKKTKRRSVAGLFGTQNAESTDEDISNLWWAEGKSSEEVIDSLKDIIEDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJW3</accession>
    <name>A0ABR3BJW3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611456.1">
        <property type="nucleotide sequence ID" value="XM_066760152.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992557"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="401" mass="45140" checksum="C40CACE01ED0D90B" modified="2025-10-08" version="1">MDASYNVLNVWRAVSALPLNPDSAATSESPSTPSVTSECLERWRALTTTKKGKKIAVLLIIVSLTIGFNVFFIYALPRITSQSVLDTIFCIFLVAVFTQSIRYASDVAFPTPKFVRYYQRKPGSPMTVSFAFEGDKKTAWKIEMLRQSLSLFTTIGILYFTWAGYIYFYPIIAAAYLILAIGTLRFPRMSIRQIIQIMCAYLTIVPVLSIMIGVLQQQFTDNSQDEEGTDKKDNITLASDWVMSLVFIFGHILGPMIPSIITAMTLRFEYTLVNEPIERSFETSPEASVRIPNEYPSFPKPVFLSSLFSLFTSIVIIETITYTIPDLVWLSITPLSVFITVPIVFGGTALGAAWCGKFRQWWRYSEVWIPAKKATNTFEENHKDLDEAEVTLLPSAAKVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK34</accession>
    <name>A0ABR3BK34_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the NAC-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611532.1">
        <property type="nucleotide sequence ID" value="XM_066760228.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992634"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC-A/B" evidence="5">
        <location>
            <begin position="34"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0242150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="175" mass="18615" checksum="67892A5D0D7BD55A" modified="2025-10-08" version="1">MDKEKLAKLQSQVRIGGKGTPRRKVVKKSVASSQGDDRKLQAALKKLGVQPITGVEEVNMFKEDGNVLHFGAPRVQVHAALPSNTLAIYGPGQTKELTELVPGILNQLGPDSLANLRRLAESYQSLTARQAAAAAGSGGEGAGEAKEGEGDDEIPDLVDNFDEAEVKKSDLEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKN9</accession>
    <name>A0ABR3BKN9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611154.1">
        <property type="nucleotide sequence ID" value="XM_066760882.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993309"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="11"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="112" mass="12851" checksum="5C2BFE5CEEFEF16B" modified="2025-10-08" version="1">MAARQASKLFYAYLPDANNVLAKRYEVRPMHLKRAEEDKKAGTLEFGRGYLPSANSPLWTSPELPAGAKPIAGSLMIFRMNTIDEVWERIKDDVYWTEGIWDKEKGDVKEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKS5</accession>
    <name>A0ABR3BKS5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611767.1">
        <property type="nucleotide sequence ID" value="XM_066759821.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992220"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0243400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="70" mass="7842" checksum="12D4109179126156" modified="2025-10-08" version="1">MEAAANKQPVKLARVLKVLGRTGSRGGVTQVRVEFMDDSNRSIIRNVKGPVRVNDILALLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKV2</accession>
    <name>A0ABR3BKV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611796.1">
        <property type="nucleotide sequence ID" value="XM_066759850.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992250"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="88" mass="9684" checksum="F366B17A94454B61" modified="2025-10-08" version="1">MRLGRNRNFTALSASPPSLSFGMGKYDWVKVFSKLLSPSFVTLRVSSTKSDSPLSERHQDMDLNANADLCQLVSQSGLVWAVQPLALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL32</accession>
    <name>A0ABR3BL32_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611701.1">
        <property type="nucleotide sequence ID" value="XM_066760397.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992803"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="169" mass="18819" checksum="EF1E28EF34A5FB75" modified="2025-10-08" version="1">MDRQLESRVLLESISKPTKLSSKDTYAHLKNFVHSLPHTPVRTQVDRLADALGVEIGAIAPEEGDRREGLREAERAAAREARRKKREEEEEQRRKAEMDSAIEGLEGDNEADGEMENGAVGQDGEEGMDDRGDVEYGDVVDEDEDEPDNEHSAHGVDSEGDNQMDEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL53</accession>
    <name>A0ABR3BL53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611886.1">
        <property type="nucleotide sequence ID" value="XM_066759940.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992340"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="177" mass="19976" checksum="627AAE29F218883F" modified="2025-10-08" version="1">MSGLESLSQQIHATLLSPPAKFLLTSKRAVDDQWWRLRLFWNGGGGDSKTGVRVWTADINLEEVSATEEVLAAAIETGMLHVDCGRRSVNLSTLDELSLHVLIQPKPIITYLTLGNVEDYVGQLIEVNYKLLSRPVAPKEDSSEVKRLRTQLARKDASPFFPIRRTRLRDCRYEILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLB8</accession>
    <name>A0ABR3BLB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="12">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_105390</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="12"/>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611791.1">
        <property type="nucleotide sequence ID" value="XM_066759845.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992245"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18002">
        <property type="entry name" value="DEXQc_INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="DEXQc_INO80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBINO" evidence="17">
        <location>
            <begin position="719"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="973"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="1547"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="354"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="480"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="793"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="684"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0243424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1855" mass="206056" checksum="C6D205A0F85D10D9" modified="2025-10-08" version="1">MADHHDSRGHYSHTRHPSASKSPVALMDRIVGRSPPLHPQPSSRMSLSALVNDSPSPPRRITPPLAAYAERHPHPSAYYPSSTTDPGYVDDRQYSYPPPRTSYVQPSTHPSPTASDYRYRSPVLPQHPPIHHSPTSYSASPYALPGQPKEDPTIAYARMREEMRAAEEARREAEALEYRRKRDMEFAARRPGSELMDDRLRIPHSSFPPSQMYGPSADQPRVIPGRNGKDYISEPPSPSELYPMDEDTERLPIDRYRRDIDVPPLPRQLPPPIPSEIGHMADRARSPPVPIAPPPLKIVRKRTKVVRPNDFLVGNEDVWEDGLIRYQSKREDEVRAIAQWADSCQVRNGLEEASLPQTQDESMEGHKGNGDTSTPINKKKRKSRKLNLDDELLGLASSPPGSPSAATAGPSKPESKHHIYGMNGPIDPANPPSPSTIVYPSGLTRAEVIAKCEAGDVQGLTEDDVKAVQDEMWMREKAAQAAENGGVLPMNKDGTVRRKPGPAKGWRKIRGIDKKKETTPGKAQSTTADSVAGSVADEEAEADIAALLDDPVTKKGKKIKRRKLEEPGAESPRFADVEDERNEHRPSDSVLPDEIEDEHSRAGSVGGSSAQDTLPSASAPPKKKNSKTKEPGVGKGRWTRPTKPEKELVKKAEALASRTSKASLVGPSDDTFGAGPGPAEEVQEEVKHEYAPNTHDPRGVSENEAKIRHELVEDLQKQVWSNITRDVPRVYRVFQGYDQSMKQIAQRRAQACVRNAFGQRNQKTMQRQSGKVNKEGAAKAKRIVKELAAFWRKNEKDEVIARKKAEREALERAKAEEEAREAKRQSRKLNFLLTQTELYSHFIGKKIKTKEAEAAEGIDLEEEEKRGMEEIAIGEDGEPLPDLDYDEDDEENLRRHAARGAHAAIQAARDKARAFDDSVTGRGAPLSGDDTMDGDELNFQNPSLGENSVTITQPKMLMAQLKEYQLKGLTWLGNLYEQGINGILADEMGLGKTIQSISLLAYLAEHHNLWGPFLVIAPASTLHNWQQELARFVPRLKALPYWGSPKDRETLRKIWSRKNQTFSEESPFHILVTSYQLAVQDEKYFQGMKWQYMILDEAQAIKSSSSARWKSLLSLHCRNRLLLTGTPIQNSMHELWALLHFIMPQLFDSHEEFAEWFSKDIESSSGGVTGNLKPEQLKRLHMILKPFMLRRVKKHVQKELGDKIEIDLLVDLSQRQREIYKALRQRVSISDLLATADNNTDNGNPKNMRSLVNLVMQFRKVCNHPDLFERADVVSPFVFGEFSQSGNLAREGDGMYLPDSARNAIEVQIPRILWTDGGKLDVPGENSLAGSDTKVLQSLLNIWTPEWINERTKRADAEFGWVKLLGSSPGEMSRRAKSPLLVQLLEGVEEERRWAEEGRFIDDSEFSASVRKGFRVASVIPNSTQPGQIPLQEIARRVWDESYLSRDDARCIGDYAIAPIVKPIASNRSFLNAQARILNQPLAHSALYGLAPSELHDPVAAEQFSHIAPSVPLTGLISSSASSQTPVSPLHIPPTKRLIVDSAKLARLDSLLRELKAGGHRVLLYFQMTKMMDLIEEYLIFRQYKYLRLDGSSPIAERRDMVTSWQTNPDIFVFCLSTRAGGLGINLTAADTVIFYDHDWNPSSDAQAMDRAHRVGQTKQVTVYRLVARGTIEERILQMARGKKDVQDVVVGTKSVSDVAKPSEIVSLFMDDEELAESVAKRKQAEAHGYIAPTVVSNGRRSQFGDGLVLDDGEGDDGFFNAAAAARANAEEEEGLGAEEESKGKGKAKAAVAITFPGSGEKRSHKKGMGKKAQAAAAAAALEKVIAGSEESPAASKPPVKKKVKIALGPDGLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLG3</accession>
    <name>A0ABR3BLG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612005.1">
        <property type="nucleotide sequence ID" value="XM_066760059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992460"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0243638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="329" mass="36163" checksum="BFF7395DA2CF3EEE" modified="2025-10-08" version="1">MSLLAPGTRCSSCTLIDFLPLLCPSCDLPFCSDHIHTHQPCVSLVSTSSHDVAVGKLDRGKKSCEKEGCERETIESVAGVSGRDEEERIAREVRCEGCGGSFCTLHRAQTSHSCPAPLIHNARHDDFLVRRSRAEDLIAKNFAGHKDRVERKMPTQKDVVKKPRTEEDNLPPSVQPAQSASIATPETAQEETKMEKKVKSKAEKLWGIHLRKVRSTATRLGGGANIPDTEKIFFEWGIDLTGAKVKTWKGKWDTKLERAWVGEDIPIGKVMDLIIAQSKTSRMADTKFSLVQLYPAPDGLPSSTSLSSHQPAKTITQGAALILVRGEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLU0</accession>
    <name>A0ABR3BLU0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612132.1">
        <property type="nucleotide sequence ID" value="XM_066759485.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991881"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="130" mass="15257" checksum="4ABEF03962162951" modified="2025-10-08" version="1">MPLTNFDAVSKSFDTNLHNLFPTSYIPSFNPPFYASLTDNNFPLIASSSLQQQQDKRQSSQQQQHHDIESYSEKESEVFEKDLPPEPRTENTRLRRRRRVYLWCKNKAYSVDWKSLTSRILSTHKAPSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLY5</accession>
    <name>A0ABR3BLY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RAB small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612171.1">
        <property type="nucleotide sequence ID" value="XM_066759524.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991922"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23307" checksum="CB9FD5C3D6656C5E" modified="2025-10-08" version="1">MATRKKHLLKVIILGDSGVGKTSLMNQYVNKRFSTQYKATIGADFLTRELVVDDRVVTMQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNSNKSFEALDGWRDEFLVQASPHDPENFPFVVLGNKIDMEESKRMVSQKRAMTWCQAKGNIPYFETSAKEAINVEQAFQTIAKNALAQEAETELYADYPDPIRIDSESTQNYGCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM58</accession>
    <name>A0ABR3BM58_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612248.1">
        <property type="nucleotide sequence ID" value="XM_066759601.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992000"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="163"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="253" mass="27066" checksum="DBFAF6B171D988B1" modified="2025-10-08" version="1">MFKKFNPKEDVSSSTSLKSSVQRNIRSSILSQIKYLSLPAWKDQPTASEAAAEQAEPAAEEKEKEEPSSGKGKGGKKGGKGKGGKGKGKDKEEKEEKEDEGEGGGGESVIDEIWPKKEALGLTKCHDRISIFTIHSVPIFFQHFDGPFIPTLKLLHKYPGMLPQVQIDRGAIKFLLAGANMMAPGLLSAGGKLPDGLEKDTIVAIQAEGKQHACGIGKLVASSADIKKAAKGVAVETICWIGDDLWKVDTIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM75</accession>
    <name>A0ABR3BM75_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612091.1">
        <property type="nucleotide sequence ID" value="XM_066760145.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992550"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="709" mass="80014" checksum="B6CA1D04DE508EA3" modified="2025-10-08" version="1">MPILTCDQCRTRKVRCMIPSEASGGGSSNRTRPQQRSKCLNCDRRKEGCTYDYTPKKTGRPRVGTSSRRAPPTSSTISFSHRSASPSMSVLRQNSVQALPLNPPQNDSPNVHRSQSPPLRSDQPRKSPATASQTAAHRVRHSTPTMNRFDSPDNFNFLIDDRNFTNPPVVDSLYDSFRHLLGTPLPLSFDFTIPSEAEAQFSRQATAQAGSNDPSAFLATRQVTENDLLKDQGPSMTQPLGLPFVSQDLSGSPTSRTLGRPLEEDRVPVLGPSPSQVTWNELGQSPLTNDSHAPNGLQSHDYERSGLVIHASFPPSNLLHLGRRPTFAQDVLHRRDRVDEAFRGLLLSIVSYTICHTNARMLEQRMDRTRQETLFRRCQRGSRMIQIRHQMKPSLVILASTIFDWVTSQSASAENLPENLINDVRRLVYSLKLNQASPPGVKDLLEVEMCRKLYWVAYDCDKTNAMYLNPVAIQDWDGTPPLPLEVDDDFITRDDVLLIQPGQQYSYMIGFNCIIRLFQILSQCILRQRLLNSAPSFEFDVWVHGEWVQETMKELRQILADLPPQLRPEPEFQEDSSTSFNGTQAANICITALCVEMALLDLKARFSPDMDIRQDRQSIAHRVFQQLQTIPIECLARNGESMRGKVAHVVLSLLDASRDTSIAQEDSKMGESLWNWWNMYSRVLCLQVIPDHPASAVPTRPGTPVRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM85</accession>
    <name>A0ABR3BM85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612275.1">
        <property type="nucleotide sequence ID" value="XM_066759628.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992027"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="707" mass="76380" checksum="16FFE1BFDAA84ACC" modified="2025-10-08" version="1">MAMIDMGMDTAWCLACSKQLDDQRDNYCSHACRLQDSQPSDSSNNHVDITAPVLAGFFPTSRIEAGSGRPSLISTDVFEEPQAKMSFRDRRAYSFPAEPVEPAARRSGSRRQTQTQETLQFIRKSSRQVSGINSHVSPNLSSTAVGAGGRPRGFSKLSKTTGNNTPVVSDSVFCSNSDSSDNEVAAGVSYLCRESANLRKRLSKTTDDTLRLPKAPVPRRLSTNLSYEPSSFHSRPPLVPSHSHPVGAKPASPVAHIIATSAGSRSRDDIVSWLNEVKCSPKDVTLDSISRSQADMLTPTQERMEWVEEGKMGTTPKGRLGSALAGLSALRGLSGVRALTNAASASDTVYKASPVPSHASSAATAVSDSEGFPLSLQVSPSQAEVSRVAVMNQPAGATPTLSTISLSDLMEPLTDAGENVDFMTDEQSASGSSSFARHRLSAVVSGSHRQGKGAGRGDLQGKTIEEEKGAQTLSPLRPLANTAQAIWNLSNYIRSFAPISIASVLTPSKRSESPTPPASRSATAGPFPPRQDSPSSSSSPSQDHITFVTPLPAARQPVQPDHSHIQTMVRSLPMDIANPMGAENGALEHKLIREQQQQLDMDSAWSKNKPHSRVRGSRVRNPSPSRSRSRGRSDGRRSRAREISKVRGSHSRHGRKVSYDADASEGEKAGYELRRGRSRREKVLRMDSTDEELQVEERRGRDRTVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMD2</accession>
    <name>A0ABR3BMD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATOR2 complex protein MIO zinc-ribbon like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612151.1">
        <property type="nucleotide sequence ID" value="XM_066759504.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991901"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21720">
        <property type="entry name" value="MIOS_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="682"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="724"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0243784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1155" mass="123684" checksum="61F8B6D69D2B45C5" modified="2025-10-08" version="1">MATELRRIALADPHTLSPPRFLVGGQLSHTVSGDVKLYEWDRDNGRMSMLGLQTEIGQLKALAWSPSPAHTHLVAAGLSTGKTLLLNLAPSTLSLPVAHPPAPPPVVATLPAKHARAVASLSFSPHDANYLATGLDRHRYDASLLIWDIHDALAASRLPPDGAAYARPELRLPATAPLTKTSAPSEPRPIQVYCPSEQVHSVAFIPTAPYTLLSSAANKVIRLYDLRAPSSTSKEPNAAGSLAQWATRTVMSLCPNPSSPLFASCESNQGNSTVRLWDTRYPGQEVVAWEVRGGVVGMSWVDSMRLGVGSTEGGVAVWDIVRCKPGVNEWVTLGGMRQIVKPKPNMHSFAFTPPTPPKHVAVMYVLKDGTISIGPISTAPVLASSSHGGVSISEPELSFIDPDMPLKSSSTSPAAGFALGLDVAGEPAGHGDRPAPAPAGAGAGGEAIYARNKFQLPPDRVSTILNEHSRLRSFSFGAASTVRPSSPPPPPPHRPSVAAAHHHIPDTLTQSYLARDRWHDDDPTGVINDRDEITGGYEGWRRVLGGDVGVVMRRRAMEGYGLDNLLLNAAIATKYRGKYKLAGVWEFVEHLTKTMSPAISSSGGYNLTHQGIYPIWTSLGTLDAASASGGPISAALNADEDGPDGEGGGGGGGGGGGGGGGGGGGGSGLISELEERLKSMSIRAGNTGRASRSASVSRRGSGTHTPRERKVSERTPHARAHPHGNTSHHSGHSASTYPQAPPSYLPAISHLLASRQTFPDKSIHPSELRPSISSSSEKVELRKLILTICGESREGGKGEVEEMLRRGERSKAAFRAFFRGDESGTVGILMSSEDPNDTLLGSTIAGFMSQSASARGSEYFNTHWPNLIRRVDDPYVRAILSRIAGEDWESVLEEEYIPLLERMVVGVQYLDDWEFSSFLKGRMSRFARSSSLHMLPLTGLSPPALSLLSRYLARTGDLQTVTLLAAFFPPGKLDQAEKKMVERWKEGYRDMLDSWGMWGERCEFDVKWGNLQRSLGGEDAGEEGNGNGKIRTCPVCNNPLSIDIEHRLHQKHAMRGTPSVGWPSERTTVCVYCQAPLPRCVICLLHVDPQRPPVNDGDCPGHVTDTIDSAYVFCLTCRHGGHANHILPWFEGGLDGGIAHSVCAVADCDCECANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMD4</accession>
    <name>A0ABR3BMD4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612284.1">
        <property type="nucleotide sequence ID" value="XM_066759637.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992036"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="210" mass="23616" checksum="6216E9485C64B3F4" modified="2025-10-08" version="1">MSKSDAFFEAVTARRSYYNLTNRSTLSNAQLQEIVERSVKYAPTSFNGQQSRAVLVAGSKHNELWDKITETHLRTLKGDKGQEEFWANKIRDQYRAGYGTVIFFEDQDIVNGFSAKMPAFSQAFPIWSENSAGILQYITWTALAAEGHGASLQHYAQYSAETQAAITELVDVSPNWKVTGLLPFGIPSGPPGREKAFEPIEKRTKFFFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMH9</accession>
    <name>A0ABR3BMH9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612364.1">
        <property type="nucleotide sequence ID" value="XM_066759717.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992116"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="1026"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="760"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0243997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1210" mass="133905" checksum="CAFC010BDFD6F425" modified="2025-10-08" version="1">MAKQPSKPAKQATLAAFFGTPMPGPRPSQPKSSQPKSSPASSLRTPSTSVAGSSPVQAKASQPIPGSSIKRSSPLKQPEPSSELTAIEDEDDELTPPPKSDASDATKVGEISNGKRQDEDEVMDDDEPPVVTGRRAKRKVVYVDPDSDNDSEDEVKPTTSKGRRPRKSLKEDSEDEYMFDEADDAAMAAALDEFEANNFSPSKSPSPPRKITKTKAKPSAPSKKPISTPVRPGPKPIANKGSESNSFLTAAERKKIQAKEDKRESEQCFDFLVNIRDKEGNRPDDPDYDKRSILIPKKSWAEFTPFEKQFWEIKQNHYDTVLFFQKGKFYELYEDDALIGHQEFDLKLTDRVKMKMVGVPEQSLEFWIAKFLGAGHKVGIVDQAETAIGMEMRTKAGQKTGGREIVRRELARVFTNGTIVDGGYLNSDDPNHLVSIKESSGGPEGTSSFGICIADASTGEFSISYFEDDICRTRLETMFRQIRPKELIHAKGNLSVATTRLLRNILPSSTAWQSFKDGKEFYTAEDTLNLLPSIFSGEEGESTIPEAITSLQDNALAMESLGGMLFYLKSLNLDKDLFSQRNFNIYDPIKEGKNLILDGKTLGHMEVLVNNEGGIEGTLAELLQRCVSPSGKRLFKIWLRSPLRDADAINARLDAVEDLMNHPRFSGDFTQLCKGLPDLERLISRIHAGSVKQSDFLQVVESFSKLQKGIDNLVDMSESLESTGVKALLRSAPDLSGMIEHIREMYTIEQNEKTIGILPNPGADEECDAADAEIERIEEELNEILGEVKKTLKCKEAVFWHSAQGGKEIFQIQLPVSVKALARWTKAGGTKSHNRYYTPETIPVIRQIQEAREIQAAAKKNFFKHLMEEFSKDRETWLTTVRVIAELDCLVSLAKASSDLDEPKCRPTFVSSSSAFIDFRDLRHPSMCLRSDFISNDVQLGGDQPRQVLLTGPNMAGKSTLLRMTAAGVIMAQLGCYVPASEARLSPVDKIQTRMGAYDNMFASASTFKVELDECSRILREAGPKSLVILDELGRGTSTYDGMAIAGAVLHYLATHSLPLGFFATHYGSLTDDFAYHPNIRRMHMQTHVDDEQKQVVFLYKLIPGVAESSHGTHVARMAGVPLDVVLRAESVSQQFFSAFNEKLVNRRQSKMPILAQADFAWLMRVVKGLEGAVAGGQDKKGILGGHEATLTDQLDIVERCVGGYEIAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMM0</accession>
    <name>A0ABR3BMM0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612387.1">
        <property type="nucleotide sequence ID" value="XM_066759740.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992139"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="2">
        <location>
            <begin position="120"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0244020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="836" mass="89531" checksum="278D6F9955A79B94" modified="2025-10-08" version="1">MPFLQSISSLFSGNSSKSNQSHYNNGRSVMNSTRDAFSLPTTNSGSMNYGNGYNDGLQLDSASSSPGPSRRTSNAYNNNDPTKDFPANPNSYPPLTHTFHRLRKSLAGSFPELLETLNPPANPALLATFEAELGCPLPRSVRESIQVADGQDLEATGSISGSGGLFYGLYFLPLEEVMREWAFWRHAEDDPTVGGNPAILATMASVPPQWIKTVYACKGWVPLLSDRTGNYIGVDLDPGANGAWGQVIVFGRDFDRKCVLWNGDGEGGWGKWLAAFVDELESGKGWEADKAASSDEEEEIGYSSYNGGGTYGEAGSGLRLAGEYRGWNVLEAWWDRSVRQWESLGLGLDIEEIERGLEEARRLTGYGVSATEGKGKGKAREGINGGTSNSNSPPQETLGGSPHLATVPGTPVPRDSDVLLPPSSPEQPPIPKIRHPSPSPVRVITPVTSTTDHPLKPGPSSTVSGSGSGSGYLSPPTHSPPRRKRVPAPAPTPIDLPTRADIQAMSAIAQAETSGLRGGWVMNLDTSVGSAARRASRLSSLGSESQGRASMDAEMVDIDLEGGRAVPFGSPHMTEDELDKQREEERMAHAGLEHRRSPAMLTSRTPSPLHRSPHSPHSPLSPHSASFHSPHSAHSASLHSPHSPYSSRSPSFETRSITTTIEDPSREKTPKASLRPPSSQSPLDVAAIPQSVLDATSMIRPPPPVANNSSLTVRGYDGEEKDRSLVRANSGASNGRRSPRPERSGTTPTPGSEPTQQRQMARDQRESSVISTDSRDGLLESGSYRRSASPVSVSDASTPEGEEVMESPSTIQSMEGAHQGKEGKTKLEEEFQEVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMS8</accession>
    <name>A0ABR3BMS8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prenylcysteine lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105197</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612301.1">
        <property type="nucleotide sequence ID" value="XM_066759654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992053"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="9">
        <location>
            <begin position="179"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0243934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="555" mass="61730" checksum="31AEFB2703FEBD54" modified="2025-10-08" version="1">MPPPSLTSSSTRFRIGFFVLLAISFSSIYHFAPSFSSHRSTSRNEQTGSSEYLIDVNSGKLQGQNGKRIAIVGAGASGSSAAFFLRRAANVIERRAGLAESTLIGDILVYEKEGYVGGRTTTIYPHDDDRARPQELGASIFVDSNLNLMKAVREFNLTLVDPNFGGSGVGIWDGQKFLFTSSSSSWITSARALLRYGPLSPFRTRRAVSSLLKKFMRLYDPSWLHERGVMDSVEEFVEAVGLGREYTTRSGESWAREVVRAGERWVGEVWEGNTRANYAMNIDKIHALAAEFSMATGGASQVEGGNYQIFQSMLADAGARLYLGTLVEDIIPQEKDGSRRFVIKTNRTELANEEVDHVFWAAPWRLQGMKSLEKEFIGPMPPIPYVRLHVTYLTTSQKHPAPSFFGLPSESTIPTTILTSAHPPRSPNVPSLPPPKFQSITWHGESFPGSNEYAVKIISLTRLSDRFLKVILGDEPTWVKRKEWDSYPKMEPFAGYAPVKLTEGVDYLAGMERWVSTMETQTISAREAVARVAQKWWGLGLGECENGDSWDWTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMU6</accession>
    <name>A0ABR3BMU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PQQ enzyme repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612449.1">
        <property type="nucleotide sequence ID" value="XM_066759802.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992201"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0244082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="41434" checksum="2AB5015B7D1D50BE" modified="2025-10-08" version="1">MDQNITRRRGVGTQGVDEQTALKGYTVIAPLTSKNVFLIDNAGEVVHKWDLPYRVGRYARILPNGNLLVGMKDPEAPAPFPFFLKYGGGIYMELDPEGNVVNELRDPLGHHDCFYEGDGHFFYAGLEALSPEQQAALPGGVPGTEAPDGKTYADTIREVRNGKLVWEWKVSEHLDPKIFPLQHYYPREHWPLINAIYPLKDGNILASLRSVSAVIIIEKATGKIIWHLDSTVVAQQHCANELPNGNILVFDNGAFRHRESFQWSRAIEVDRATKEIVWQWHAPTKETFYTPFMGSAQRLPNGNTLVCESAFGRVMEINTENKVCWEYVCPYFAVYPEKNAAGFYPSESNALFRAYKYAPEEIPWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMW1</accession>
    <name>A0ABR3BMW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612464.1">
        <property type="nucleotide sequence ID" value="XM_066758977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991359"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="58"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0245380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="590" mass="64140" checksum="C21B23F7B50E7710" modified="2025-10-08" version="1">MGKITVAPSREEVPSLSALGIKVHPDALTLAYDDSALASSYGGNGLKDLFASRMVLLAASAATIGGLLFGFDQGILSISLTMPQFQEQFPETNAEVNSSASLNKGVMTALLELGAFLGAFMSGYVSDRYSRKGSLAFGMVWFIIGSVLQSASYSFAQLVVGRFIGGIGIGVLSSTAPTYISEIAPPNIRGALLVLEQFSIVLGIVVMYYITYGSRYLSGDGSFRLPFALQMFPCIILGGFLYQLPYSPRWLALRGRDKDCLESLCRLRQLSDTDPRVQAEWITIRAEAIRNREVLVRAHPSMADQSTKSELKLELASWVDMFKAGSIRQTMIGILLMFFQQFVGINALVYYAPTLFEQLGLDYELQLTLSGALNIAQLVAVVAAFFFLDKFGRKIFLIVGAIGLTVSHAVVAAMIGTYSDNWPAHKGPAWVGVGFIFGVMIFYGVGWGPVPWAMPAEIHASSRRAKGVAITTCSNWLNNFIIGLITPPLVSGTKGYGAFIFFAIWSILAGIWSVFFVPETKGRTLEQMDAVFKSHTAIEDAQARDDILQIICKEALNSTNNPGQVPKREVEMVESVDEKKSGTPSTISTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMW2</accession>
    <name>A0ABR3BMW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611313.1">
        <property type="nucleotide sequence ID" value="XM_066760552.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992960"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0241931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="905" mass="100687" checksum="DA5EC11507D9F227" modified="2025-10-08" version="1">MDYSQIDPQLRSLDVQSPGSVSMSRASNTPPRVLARNSACHQCRKRKLKCDAQKPVCGNCAKFRARGKSGDEQPHEDCTWDEPKEPSARTKRRRELAKRQAMESDHADGKEYGEKTKRAKLNELEGRIAAFEGAMEFQPYPAIINQPPVQTLQEAMPYAQQPGSNSYAASGQYDYHHPPFSIGPLSDFTFRSDGDGQAIPNHGMVQDKDEIAREERTRPDQAVNQALWEKRMGHAALREWSRSDSVAVETGPTFTQSGQMGMVFPDWPKDLPPPAVIEHAIRVFFEKVPLLPKMLNKTLLLQSLQRSPSNPEFACVSLIHAILAITANFISESSLSSPAYFPVGTPSDATIHPEYDFEIPVNPSTRGGSCSMHFQSSSFRTAMSPMARFQLWHRRKAFETFYHYVDKGEKFLHSLQAQVIATTVDQYNAWWTDLWIEAGSCMRIAIPMRINESPHYDETSLRRHASLLLHPAQTAYEQAERDRTWWMTFLLERSVTATTTWPSSLVNEDITVELPCLQSSFDSASGVLGGSQNFQSPDLLTNHPPEHRDGLSFLIKSMKLLGDVNCFFRRYSRGRHSIAGYVSNPTFRLLLSQINAFRMSFPPEFRRPTQSLPGLGEANALDRDLISALWITHSAIMGLGEPLITRDSWMDEGARVTLSAIRATLSLLYDVTSTSYDLSLFSPHCTFVWSLSCRGLIRFMGTALQANDVVSASVFRSEIEVFRMALKRYGERFPIGIRHLKVVDDLLEEMEMSQVTGLPLSINYDCRRSHLSERPVGASVSEETVSSQVVTPETSSSIGEVSFNVASVSTYPDSTSANGSYTANRHISTSQVPKAVKTLSSPVEGLNTNMAGMPAIAASSPLLMNPSPGEGFDISSFSFDVNNVVGMFEGAEGTFSGAEFGLWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMW3</accession>
    <name>A0ABR3BMW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612133.1">
        <property type="nucleotide sequence ID" value="XM_066759486.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991882"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="86"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="507" mass="54160" checksum="30FA069C669FDBF7" modified="2025-10-08" version="1">MAPKKKGQKMALHEFFEEAATSGSSWADDDFDLPTAPAAREESGSGLKRGDPGYFESLPDRGSRQATFPGAPAQREELPLPTVPPFTAFIGNLSFEPDVEDEVRAFFNDLDPVSVRIVKDPQGKPKGFGYVEFKTQDGLKQALDRSMSQLQGRTIRVNVAEAPSTSRHPPSAAEEASQWRRSTPLASRESSSQPSRRTGGPSEPAADLDWSVARGAKFTPSAPAAPHSGIRRDSSGPGHAREPRDPGVSDTADQWRSSRPLAEKLDRDVPPHQAGVAPPIVAPSLADTEQTWSRGTKLRMPASTSRQSSADSTPSSGAPQERKKLTLKPRTAGSPSATAATVGAPSPGIFGAAKPVDSAAREKAAEEKLAQREEERRKAREEAEKQKAAAGDKPVEGEKLGWREEKLRSIKAAQDKVAGKPAPAAGTAGGGRKGSADKGKKDEQGFEQVQPSRKSSQTGSTAENKPKKDYSTRPQFSFAAAAGSMRNSLVEDKDEEDVAKGVEEVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN09</accession>
    <name>A0ABR3BN09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spt20-like SEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612536.1">
        <property type="nucleotide sequence ID" value="XM_066759049.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991434"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021950">
        <property type="entry name" value="Spt20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="2">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="328" mass="36022" checksum="8D86362F8C8ED01E" modified="2025-10-08" version="1">MASASGYNHHRFARAVLKKSRKWEPSLTVQLFSNHWRFENSPLNFQYDGPMKPFLLAIRSQVIPASLIPFLYDIQPPISFVDGCLVVELQDYRRSPESRSRVVMRPAAETLAQTIDVMLERKGHGWDEQLAMELESRIITATSPPLYLGTSIMATRNATLALALTSPAHPNLSADGALRQPMAMESDAQSSLEKMRKLIAAGSRAGAGAAPFQPDWLVLRAKEQYEAVRLHRERGGFLPQGSQGPAPSTAGDEAPRPPVVDDKKKKGKKRPNVEEGEKPKSKKKKKQPAASSAAAASDAADGEKKKPPAKKEKGAAAEKKKKVEKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN84</accession>
    <name>A0ABR3BN84_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611448.1">
        <property type="nucleotide sequence ID" value="XM_066760687.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993109"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="3">
        <location>
            <begin position="99"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0242066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="265" mass="29469" checksum="96BFF2ED70E5D1AF" modified="2025-10-08" version="1">MSLTHVRGATAIRPTLLRPAAFHFSRSLAPPLTSSLPSRSFVSTAHILNTANPQAFSQPNPRTSDNSSSSSNADVTKKQQQRKSGGSEPETEPKSAYAKFKALSRKYGSWAVGMYFFLSTIDFSLCFLLVHSLGAERIEPLMDSAKEFYRSKRYGVEEAERMRIEDEKEREEEMAAEKKDGKQGKSGSGWFGKTFWAEAVLAYTIHKTALLPFRAGLTVAWTPKFVGWLSKRGWVGKGGLTRAASHGREKVRGASDRMKVKVKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNF8</accession>
    <name>A0ABR3BNF8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_104729</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IND107</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612679.1">
        <property type="nucleotide sequence ID" value="XM_066759192.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991585"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="135"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="457"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="40"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="700"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="708"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0245595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="725" mass="79966" checksum="55797F575DA8F1CD" modified="2025-10-08" version="1">MSFGSCSRHALFTSGALPGSFRTMTTSCFKRVYRTQIPSGGPLSKHLRSVPPSASQPLTSFSTSCRRQTPPPRLPPTTPQSPTVPLKASTTPPTSFNASKPVATESQDKTDWSIIVKLAGNIWPKNNPNVKLRVIGALTLLVAGKVLNVQVPFFFKTIVDSLNVPITESTTVWVLAGASIAGYGAARVLTTLFGELRNAIFASVAQNAIRKVARETFEHLLNMDMKFHLERQTGGLTRAIDRGTKGISFILSSIVFHVIPTALEISMVCGILSWKFGWDFAAVTAITMLLYTWFTVKTTAWRTTFRKQANAADNKGATVAVDSLINYEAVKSFNNEKYEVAQYDTTLKAYEKASIKIATSLAALNSGQNFIFSSALTLMMLLGAQGIVKGTMTVGDLVLVNQLVFQLSLPLNFLGTVYRELRQSLIDMDVMFNLQSLNSAIKDSSTAKPLRLKGGEIEFRNVAFAYHPERPIFRDLSFKIPAGQKVAIVGPSGCGKSTVFRLLFRFYDSNSGQILIDGQDIKTVTLDSLRRSIGVVPQDTPLFHADILHNIRYGNLEATDEQVYEAARKAHVEGTIQRLPEKYATKVGERGLMISGGEKQRLAVARVLLKDPPILFFDEATSALDVYTETELMRNINSILTGQGKTSVFIAHRLRTISDADLIIVLQDGYVAEQGTHEQLLAVTGGVYHRLWQAQLTESTQPTDEELERQREELEIVDEKKKQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNJ4</accession>
    <name>A0ABR3BNJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5 10">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_104775</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5 10"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612725.1">
        <property type="nucleotide sequence ID" value="XM_066759238.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991631"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="14">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="15">
        <location>
            <begin position="198"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="13">
        <location>
            <begin position="353"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0245641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="434" mass="47467" checksum="DFB9352DCEE28E7F" modified="2025-10-08" version="1">MSPSVFKIAPGINSYDWGKKGSASLAAQLATTSIPDFSIDENKTYAELWMGTHPNNPSRLSDNTLLSEHLKSHPELIGSTVSSKFEDCKDGSLPFLFKVLSIGTALSIQAHPDKPLAKKLFDEKPDVYKDPNHKPEMAIALTPFLAFLNFLPLPVLLLHLLTVPELQEFVDSSLSKSLASSLDLPTSQPPDASLFKPTGSPATAQQKDILKQIFAALMSADKKLVEEAISKLIKRYKAKQDIRENEKDLVDLALRLNDQYPGDVGVLCVFLLNVVELKRGEAAFLGANEPHAYIEGNIIECMATSDNVVRAGLTPKLRDVDTLVSMLTYEAAPGDKQLLRPTQFQKGDDTTKLYDPPIAEFSVLRTELSEGAKTSHRPVEGPSVCVITEGAGVVRDGNDQTEFVRGDVIFVGAGKGVEWEAKKALEMFRAYVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNU4</accession>
    <name>A0ABR3BNU4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612433.1">
        <property type="nucleotide sequence ID" value="XM_066759786.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992185"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0244066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="659" mass="71328" checksum="96ABCAE835C84CB6" modified="2025-10-08" version="1">MSRARNSRARSGRQPESLPPRLPEDVYNTRMRDLLELEPLPSDEELDKYWSTALKRLWHGRFRGKAGYTDELVPNLKRCIKTRTLDSPNLTDDVAVDLVPERPLSLVLSATMRTPYSQTKVKAAVDKWSPKWETAEEQEEEEDGVQIASSKASGMSAGGMQPSTSLVKSKTTTSSLRRGIRRPDYVIEVGCSHIAGSESTSVPLTIEIKAFPLGDSGHPQSELEADKAFVRGLSQTAMYGLAGWEMFRYRRGLFICGPTFSRVFVLDDNALAIEVASPPASLSALNVSSFFSSYNYHSMPHSLIFRRVNEQGVSSPLLRYGPRYTINPLSCRLLESFIRGVVERTLGQTVGEALGCQTEEMNFDSLSASHPGIALGILTPSSSRLDLVKHARHSATISQAANSGAGRKKKVSPRKSSYLEARGNRKDRGGGGGGSGGSGGDGRDGRSGRSGRSGRSGWGSKGDQNRGASREGASGKRGGDGGTGSGACDEGGEDTGIKRSHNLSSDNDRDRFIDALDASLEAEGVGWKGSGCLTKADRCNRLNDWLEALPQAEKPIDIPSNGASPSTPALEDVLAHLAMDSIEYQELRIANVLGDLGVHFVSISSAQMDELFSANPSVIITSTQDKGVNHRLNCSTLSRSHGKNSEWRQRDNLSHLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP54</accession>
    <name>A0ABR3BP54_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_104007</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0246975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612936.1">
        <property type="nucleotide sequence ID" value="XM_066758488.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990863"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0246975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="191" mass="20602" checksum="1AA07D6B159A61D5" modified="2025-10-08" version="1">MSAPRVIAELVVTGIKVLGKATAAAGQQAIRNFKVKPEGAPDSSPVGAGSSKNSITSQLQMSLDEARLILNVKKDDPMEVIQKHYDHIFTANSPPPPSAEAAPPIKGGATGKRSKVPTHSHYLQSKVFRALERIKAEKEAELSKTEEGDNEEHLLAVERTVLESPLGAYCILFAALSYQVTCCIKIRKDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP61</accession>
    <name>A0ABR3BP61_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612914.1">
        <property type="nucleotide sequence ID" value="XM_066759427.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991822"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14101" checksum="47F8EF19F2A4FF9D" modified="2025-10-08" version="1">MSPQSIFVSYNLYPPAETPQPTAGPSSQPVPSSATFSFPIPPPSLKTKASTLSATTQYYTSASAALLVSQAMLNEKLTYWKDAIGDREKAKEDVGAVGFGRGKAMMMSNEVIGEMKNGQEREGSSEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP95</accession>
    <name>A0ABR3BP95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105679</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612075.1">
        <property type="nucleotide sequence ID" value="XM_066760129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992534"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7 9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0243708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="549" mass="60232" checksum="3D7DCCEE480397CF" modified="2025-10-08" version="1">MSSEKAEFDAEVKAFEAFAKSPRFARTTRPYTPADVVSKRGTLPISYPSDVQAKKLWKILESKARGEGGGCTATYGALDPVQLTQMAKYLETVYVSGWQCSSTASSSLEPGPDLADYPSNTVPNKVAQLFTAQLYHDRKQRYTRSAALAKGQDPGERIDYLRPIVADADTGHGGLTAVMRLTKMMVESGAAGIHIEDQAPGTKKCGHMAGKVLVPISEHINRLVAMRLQCDIMGTTNLVVCRTDSEAATLLSTNIDSRDHSFILGSTNPSLPPLNDLMIAAEMEGKYGPELQKIEDAWTKQAGLKLWPDVLADALSKHGVSSKKIAEFREQSIGTSHASTLQLAHSFGLPASATPYWSWDTPRSREGYYRYQGGTQCAINRAIAFAPYADLLWMETKSPIYAQAKEFADGVHKVHPGQWLAYNLSPSFNWEKAGLGKKEMKEYVWELGKLGFIFQFITLAGLHSNAYINDLFANAFSKEGMKAYVELIQSREREIGCDVLTHQKWSGADYADALLMTVTGGVSSTAAMGKGVTENQFVDDKTKDVLHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPP1</accession>
    <name>A0ABR3BPP1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-rRNA-processing protein TSR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613130.1">
        <property type="nucleotide sequence ID" value="XM_066758682.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991060"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046853651" description="Pre-rRNA-processing protein TSR2" evidence="4">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23220" checksum="8AAAE15AD9E8D942" modified="2025-10-08" version="1">MADATSPTIVLFARGTLAILDLWPALTIAVCEQWGGSESAEKKTWIASTLIDEFESRATYLPTPVPDSSAPSAVGPVVDPADANDPPLDQDDIIDLLTQIMEDEFEARLEDGSIEAVASDIVRLWKDLLTEEKPEIIVEALEKKANEVRRAGVQVSKGAQDEGDSSSGEEGDEMEVDGDEAPQLVAREERREKQEPVVDDDGFTLVQKGGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPQ5</accession>
    <name>A0ABR3BPQ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal RNA-processing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613137.1">
        <property type="nucleotide sequence ID" value="XM_066758689.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991067"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39676" checksum="D551758689B3C8A6" modified="2025-10-08" version="1">MPAVTSRKGKSRAQDTSDDKPEAVLPLGKQLAHTDKKVRDKAIASLVAFLSQGGDTEGSSSTYVNLEDKEMAKLWKGLFYCFWMSDKPLIQQGLAAELAELLLKINPRTNSAGDKFKASLAFLEGFWDSIAREWAGIDRLRMDKYYLLMRRYVNATFRLLAREKWEKEAIAAVNRILMKEGGVMTWEDRRVPTSISTHLSDIYLDELNKVLGLPEVDSQPACPIAAVLQPHITLLARTPLSTVHTRIMSSVFSPLLTSLTLASSSLDENDERPAKRSKKSIEDEPMYAHIVMHSCVGEGGKQERNSADQLRNAVLRAMFNEAANPKSTEPNRRKIYKVWREEGGDDDDDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPV1</accession>
    <name>A0ABR3BPV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613182.1">
        <property type="nucleotide sequence ID" value="XM_066758734.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991112"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="171" mass="18841" checksum="2E26562F5068A4BB" modified="2025-10-08" version="1">MDPGKWLGDLCEEAGIQRPEPPSHVEELLLSKIHLQVQYWNVHGQQTAYAGHTCLFTRENAAFLNTLPILPEHWMFLYFVMLWLLRRLLNGEGMREADGEQVTNGETTAGTVEARSPTLGPISAVTSTSATTATPTRPSSAVPVAPTRTHASRRAVNPQVDVPSRIAETWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPX5</accession>
    <name>A0ABR3BPX5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613204.1">
        <property type="nucleotide sequence ID" value="XM_066758756.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991134"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="73" mass="8055" checksum="7130FD8BB5D196F8" modified="2025-10-08" version="1">MRHQPILVPSRNQPPTLQEDLEGSQRPYRLQQLAVTIHRQEIVGLLLRKTGGALSSAIASISVFLELTCFCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPZ8</accession>
    <name>A0ABR3BPZ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104301</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613227.1">
        <property type="nucleotide sequence ID" value="XM_066758779.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991157"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0247266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="434" mass="47306" checksum="E3263981BEB1D25C" modified="2025-10-08" version="1">MLASSSSAVSEDPNSKEGQLLKSPNAKDLASQPGPNPHDVLSAPSPFDFISEGEEISSGQVGKLGSSSSSSSSPSQSSTNSVSSKDAPLKFSSRYSLPSNISVPPEVREHLTEWSKNVLNHSRHVIQEAQKKFVGLGLKVNEMTGYHEVERLKHMVFEKEDELQRLRESARAAKAAYDEAVAARSEAQRETNILLERKHSWTDADVSKFTSLVRADHTSSHAVASTSISLKDAEVAVDKSFSQLMQVILQRYHEEQVWSDKIRSVSTWANVAGLAINFIVFVGAVLLVEPWKRKRLVEKLEERVASMMERVDHRLEGVEGHLERVAAGPASANAIKEQHSHAVVLEAEDMPSKSAAHPSEFISSQTIPLIAGVDPAMNVPESQSDPFFTQTVGGLPDYLDPLVKPSQKRDLAVAGMAGAVAAWILMGVMRSVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ07</accession>
    <name>A0ABR3BQ07_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613081.1">
        <property type="nucleotide sequence ID" value="XM_066758633.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991011"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="321" mass="34986" checksum="20DC0FE62B551938" modified="2025-10-08" version="1">MPPQPQPLRDSDGFLMPAPPSKRTQLRQANSLPTTADIYAAKHGIPLDVQMALQSVGRRGRESVARGHRSFDRTQSVPNLVIGNSAAPPMSSFTSTHDVMQHARGVINKELMRARELQPFGSTSSTSSDVDALDLEGVEDKRTRRLKFGPDGEVEEIYEQGSSKGNVGFRKGTKIEDATLVPSRKRRSSPPEPEGSDTETDDIDEDELQPSVTFNAVESVFPPVFASPAITHPELFGPLPGSSSTANDLDNAAKTTGGRQFKGLPGGGRKLGWQKSASAPVIGLRRWGDMVVDGEEEIKDEAKNESLEDGFEFNNWEEVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQR1</accession>
    <name>A0ABR3BQR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_103594</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613487.1">
        <property type="nucleotide sequence ID" value="XM_066758085.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990450"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="75"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0247526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="256" mass="27647" checksum="934FEBC09968E7DC" modified="2025-10-08" version="1">MAERGGFGRGRGGAGGRGRRGPRRGGKKEEDKEWVPVTKLGRLVKDGKIKSMEEIYLFSLPVKEFQIVDLFLPSLKDEVMKIMPVQKQTSAGQRTRFKAFVAVGDFDGHVGLGIKTAKEVATAIRGAIISAKLSIVPVRRGYWGSHIAEPHTVPCKVSGKSGSVMCRLIPAPRGTGIVAAPASKRMLQMAGIQDCYTQSKGCTATQGNFLKATMAALAKTYQFQSPDLWNVIAPGLTPYDEHSAWLAIAAKKAANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQU2</accession>
    <name>A0ABR3BQU2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613521.1">
        <property type="nucleotide sequence ID" value="XM_066758119.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990487"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="68245" checksum="AF71682905AB858B" modified="2025-10-08" version="1">MSIRTRKRYCRSSNPWPGPALIQTNQATDPATNDRRDKSSESKPSKPPTPAPTPITPSNPLLPDLSRVATAAYTASILAHPPPPSNYGRPGTHPFSLDSLPFTDADVPLPKPYNSKYPHPITAYASPGVNPETVKRSGYGKMLQDIVKKDVKDALGDIFYDAGFRSLSNSVYLLFSYESVGQGNGIPESLWSKFENVNNVRLPTVATATSSVAAQVEDIPHRFAPSQINSTCSGDLNPHCTMENNQAMERAFRPLSRESISSPSCMQVQTQPHMQPRGEEEMDAWKTDTWKAWDATERCRYRPSCQFAHGLEGLRLTRESLMLRGLASRSRTPVILSPTSSHRSSFFQYPVTPRSVQTQIYAHEITAGCPYNAMSSDRRMSAPHSQLGMVAEDELQFGTFNSDLNLGYRRGSDVSSGFPFAYSQDLRAPSSRRRFDLVSPKFTPSPDEEYKDCLFPLSKPKQPSSDFAAISVMSFNSDSLSAKEIQRRLVPQPSSLTLYTSSSSSSNESVGGGSRSSRFSAFEDGLSESLITPTDAGWENNYLGSTCGVPKSKFELDIRSSHRGIGDEISFGAIGMRKGGLVKSGSMDSVNTTESPAHTSLSSMVRSKGSTTYEFSSGSSIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR73</accession>
    <name>A0ABR3BR73_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613652.1">
        <property type="nucleotide sequence ID" value="XM_066758250.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990625"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42034" checksum="B1FFB1A239B62E76" modified="2025-10-08" version="1">MTATYATASKIPVPTSLVSGLRSLISSFTSSSTPLLPFIPKPLKLILLLLFLSHCPSWPFVWHVRVWWHGVKAYYLAWHKGRARYLVDWKAQNDKNGGIRSLRVRHKRIAGVDDCDYNMHLSNSSYAKNSDALKMDWCIKALSPSFTARGTYMALGATHYIFFKEIPIGSEYTMEAYCLGWDEKWMFLACEFVIYPKKTSKAGAAKNKVTASVVSSAPHIVPTISAPPTRTASPNTSTPVSGTATPAQGTPLGNKVEEIKRAWLARRKEDPRKDGGVTCCLSISEYCFKIDRVTIPPRISLYISLQSPSKEHQDRARAILMSKDGGRAFLRGGWREEFNSELLGTDIGLAEGEEFQDSWIKRGAESMEKVVDGLSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRJ0</accession>
    <name>A0ABR3BRJ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613760.1">
        <property type="nucleotide sequence ID" value="XM_066758358.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990733"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="6">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="88" mass="9824" checksum="25D46AEAC4E899D0" modified="2025-10-08" version="1">MSAPTAIPALDEASKKELESFLEQEQAKAKLQASIHELTNTCWNTCITGSISSKFSKSEAQCLENCVDRFLDSSLYIVRQIEAQKQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRY7</accession>
    <name>A0ABR3BRY7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613756.1">
        <property type="nucleotide sequence ID" value="XM_066758354.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990729"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="4">
        <location>
            <begin position="70"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="191" mass="21200" checksum="3C0B5C223027CAED" modified="2025-10-08" version="1">MSRQLDNVNPTIFAPSTPNFVRRSTGKSARSSLWAPEALSDDEEDYYSTRASGSGSVTDEEEAREDIDAQEVYDLLRSITDPEHPVSLEALRVVNPEDIHVAGNRVLVYLTPTIPHCSMSTLIGLSLRVRLLRALPPRYRVDIRIKSGTHQSEHAVNKQLNDKERVQAALENKHLLSVVEGCLATAGKRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSF0</accession>
    <name>A0ABR3BSF0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endonuclease</fullName>
            <ecNumber evidence="8">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103188</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="8"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614072.1">
        <property type="nucleotide sequence ID" value="XM_066757688.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990044"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045438683" description="Endonuclease" evidence="9">
        <location>
            <begin position="21"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="11">
        <location>
            <begin position="77"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="10">
        <location>
            <begin position="78"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0249885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="364" mass="39851" checksum="7ED165ADEE49D5C4" modified="2025-10-08" version="1">MPTLGPSLLFVAGLTLGVGAGTFLARKAAQPNVPLPPPPPEGGRPDFKESKALVPTATGIVGPLQGGFPGPTPDIIKRVAYTAAYDRRLRHPAWTAEHITATSLAKVPPPQVKGTPVPLEAARAADTSSQPEVIKGDRSKSVFKEDDGIPEMFRAKLSDYFRSGYDRGHMVPAADAKISQQAMDETFYLSNIAPQVGDGFNRHYWAYVEDFCRRLTTNFEDVYVFTVPLYLPEKHADGKWRVTYEVIGNPPSISVPTHFAKVILASRPDFSYPQKPSSTSTALTSPQTVKELALGAFVLPNKEIPDKADLRTFIVPVEHVEKAAGLKLFNEEVKTKSRQLCAVTQCQVIVRRFDDARKQLGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSI3</accession>
    <name>A0ABR3BSI3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin-14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614097.1">
        <property type="nucleotide sequence ID" value="XM_066757713.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990069"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28053" checksum="65118A3909679068" modified="2025-10-08" version="1">MKADRSYPTVLSVPLRFNTSAGQPSKMPHSRTLVYYFRRLTQLISIIVGASSAVAALWSLILLPLLHASFSARKSLVEGQIQPMGTLLEGVVGLQAKLFHFSSLQPDKGVEEESVEADLSTVTAIKEIESYAASTSSKTDSDMPTAIFPFLGLRSLSQSIHNLTTVLDATSTTRISLISTLESYTSHIHRQLFLAKSPGYTSDRFTVGLGTLSDNLKKEGEHEKKGEEWDAVRKEVRAVKGLLLNRRAFASNLGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSQ4</accession>
    <name>A0ABR3BSQ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein arginine N-methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614172.1">
        <property type="nucleotide sequence ID" value="XM_066757788.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990144"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="368"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="504"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0249985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="580" mass="64229" checksum="D0B47D2AD71CE9C1" modified="2025-10-08" version="1">MSYKVTSAAPPSISSSSSVSSDDSDDRCSDWASSFGDARQTKSLFDDTILPTQELAVQYDRDNWDFDLKEVCEKLGLDLLGRIRLINLIRNAGLDKDQISALEADDPLLKDDNLLIPVIPDDPLLQYDFDDFWSDDDDEPLQAPSAGPSKDAQSLESQKVTLLEAELEKARKDLAAMQLLVTKTIGSEDDETEEIQVKMDGNGKGKGKGKAVERDDDTHYFHSYEENDIHEIMLKDTVRTVSYARFLLSNPQVFKGAVVMDVGCGTGILSMLAAKAGAKHVYAIEASGLAVKARENIQKNGFANVITVIQGKVEDIQLPVKEVDVIVSEWMGYMLLYESMLDSVLVARDRFLAPNGLMAPSQTRLVLSAITGDRVCRERVNFWNSVYGFDLSTMNAVGFDEGLTEVVDEEEVVTTESIVRDINSHDATVKSLDFHSPFALSSTSDKPTTVRAFLTHFDTFFSPLSGSASHFPPSYPVDIRQFGDDEYTSPVEPLTPSSGKTGVEVSFTTGPRGKYTHWKQVVFLVHKPIELAPGEEIVGQFRCKKSDTNSRELDVEIHWAKGKKGEEGERTCTVQAYKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BST2</accession>
    <name>A0ABR3BST2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614026.1">
        <property type="nucleotide sequence ID" value="XM_066757642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989997"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="320" mass="36286" checksum="FDCA84EA10C9CD53" modified="2025-10-08" version="1">MAYNSNHPRPYTLDYSPNEELEEFDVRADFDVKGPRWRNVRSSTIGLGVLGGDKNNSYRPVSEHIPPLGHTYSQDTRKSLASREELVSVPVLGPEWKKTELHDLSRRGQSGIKAEKRKRAWLEWRRDQRGLCGVRWLTRRVVVGASFLFCVALAVTLYFVIPRAPNFEFYHDQPFTVNNDTISFNRTPTNFSFSGNLNLWGDASSSYFPVHFAHLEASLYDETTNKKIATGDWGNHIMQHKTQQAVVLPVTFAYSAINTSDTTWNDWYNACGHIWPGTVRSDLKLKLLLKMSIVGLTKKPLTSTLISGVTCPFELSADNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSU3</accession>
    <name>A0ABR3BSU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614210.1">
        <property type="nucleotide sequence ID" value="XM_066757826.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990182"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="681"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="776"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="937"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="681"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="705"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1382" mass="153495" checksum="ECE389C4C5D21A9A" modified="2025-10-08" version="1">MAQLAPPPPPPPPPRPAPPPPSKITVRFDHAHRPPPALPYQPLHPSSLHTSILPSPPSSRRASPLSPSLPSATTDSSDALPGDRRPPLPRAHASQRVWSETLPRTGGSLLASGTRPSRVMGGFETTSEEDYLADGVPTSSSGTGMTTPGDDRLSSRDVSTAGSGMQVAKPAPKRWSDRIPRSDHKPRRKPSKDTKDTPARPPSRASRGGGRSPSLGSHLPARSDGGHGFPNGLAARGRTASSRSQYDPAARPNRQDSMSSPDSRPVDGNRHSGERTSSPEGISKDKGKGKETASDKDVGHDRQEKQQASTANTLVESLGLGGLNIKNISLNTDQIHSLLSDSDLASAIRMVNGNSAISPRISAIDPYNHATPSASASTGPPNHVSPYLVSAPPPLTKDSPNSRSYGRERAVSAVSSIGSVTATPTSTTWSPRFRSTSDVPAYDGHGLGNPRPRSASRASMSTDMHGGHIPFTHHLPMVPQEADEEEDNYDEVSSQTHSATVDGVQPVREQSLLWEDSKAKETTKKEKKKKKGKSALSNLFHFGRQRGSNGNGNGNGTEGEHTPKVKEKEHHWRAPDWHSEEHARDREAREREEEMRRIEWEKRQEEIMQERRYRALTQVAAHPHAERLAYRTGAHLRAYYQHVYDCLENPPRLNFTKMLRWLTETDRQNALRAQYYASHHEHDANHHTHEHGNAKSNGSSSRVNLGSSQRSVGSGRTRSVSSHRHSLRDDVPSPQKQVPDLVIPRRGWKYTVEDIQAFRDSGGVVNYFVPPRQIHPYNDEVEEEEEEERRSASPQTVANRVEHDLNRNHFGRRTATPQSQSRDLFDLSRDDNSSAAGSSKKGHPHDFSLRTPNNTASNVSLVDLDQGMRETNLSRSTSFDTGGDKSASGKGDHRVSHRSHQSLGGVGHSSLSHALKQPFGKLSSVTKKQRTMPHFHPYGADHERGQTNDFAASSDRPGVALSGSFPSAQRSGLVSRDSLGSVTNKSNVNQARNNVNRLKEPSFFKRHGLAGHESMTTDEEGSRLKLFIKGTRKIGLDDHKKRPDTNLAECRDEELKEAERIYAREQQFKNNQVQEEEEKAKVTKEEEAALKRILDLEKDIYHERAQRLATVKDRLAVVNSNIHVIDESIRQYLTQIDFARDEAKIGMGLEADWSLVEPLRSKYTRRRRSIDLADDANGELRDTVPPLRSFDSGDSDSDGRHRPQPAPIVRRARSRSNSRSGPGQMPKRTLSLHNSIALHHIDPLQARHHPRRTYLAPDGLTRVDPVRHVELMIAFGKKQEKEVGKEKDDMAKQMEKMIGQIEAMIRQKEEVRHWVADVLERAEKAKTQLERLRIQENSFLDLVHFARQRDQLVDSTTKALGFTIRVACLTLAVDGFEIGDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSU8</accession>
    <name>A0ABR3BSU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614204.1">
        <property type="nucleotide sequence ID" value="XM_066757820.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990176"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="170" mass="19526" checksum="1DC1754EFCCBA252" modified="2025-10-08" version="1">MQPRGAAVKRPLYPPRPPPGIKRKLWEWKIKFDCTFALSVMWPGEQMVIWATFVIIALLVLVYVYNYLPSQIVHTSQRLAYYIHGDETAHFMEQIGRNIVHEGIPGNNFKQHDKAQWLIVKATYCSINIPKPLFDQRLDMDICSKALDPIFCLGSFPSASHLPAVQLYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSW5</accession>
    <name>A0ABR3BSW5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614231.1">
        <property type="nucleotide sequence ID" value="XM_066757847.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990205"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="8">
        <location>
            <begin position="103"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="225" mass="24390" checksum="5B00381C4B2C97B3" modified="2025-10-08" version="1">MAPESTPKKEKKDKKRKSEAADTSIAPEPVAPEEGTASAEAVIMEVDGDRALKKQKKEKKEKRKSLAADGAEEAEDKKAEFTVPADAISPIASPLAGKKLSKKLHKTVKKASKARQLKRGVKEVVKALRKGEKGLLLLASNITPIDVISHLPLLAEEAAGVEYCWVLSKEELGVYAGTKRATSCVLISTTPNKKATVSDEDRAEVKAALEECMDEVKKLETVIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT12</accession>
    <name>A0ABR3BT12_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614116.1">
        <property type="nucleotide sequence ID" value="XM_066757732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990088"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044839">
        <property type="entry name" value="NDR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234:SF2">
        <property type="entry name" value="OS05G0199100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0249929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34446" checksum="37B8CEE0B472A0F1" modified="2025-10-08" version="1">MPAQYDDPYNDPYSGQQRQHTSDANFADPRAHYGQSYAYHDANPYEEELQYPSYPTDPSSGDYLNDVNMEKTPENVRYESTERAQPGRAGLRRPATSFAGLGPPPRSTGILRVWRKDERGKQWSRGGGIRTSLRFCCCCVTVAILMIVSIILAILLYVRPPSVALNSVTVGSDPVSLTSDGLTVSFDLSISVSNPNWFDANFKEITATARYPGNNTNTFGGGTLYNLDFKGYTESTFNFPFTLKYVYPNKVILNDLIKKCGIAGSAQDITIDYDLNMKLKILGITIDPTVSNSASFECPITASDIESIIGSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT21</accession>
    <name>A0ABR3BT21_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614282.1">
        <property type="nucleotide sequence ID" value="XM_066757898.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990257"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="102"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="252"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="294" mass="32745" checksum="9914B35D30526EF3" modified="2025-10-08" version="1">MLGPLVHIPRLLRVALLCAFIVIVPTLYLLYPSAERLPAPGEWQAGGIDSEHWREPVKPDFTRYEYEEGRAWGEEVVTQGEASVVMDGDVIHGGVIMPKLENATAKAELGRAAWRVLHLMTLRYPDEPTEDDRLALKSYFHLFSRLYPCGECAQEFQKLLKEYPPQTSSRKSASLWLCHVHNQSSLVSVESSPSSATSESYHKNGVDVVKAMTEAVHDPTILSHGGAALQGEFEVVASGEGVGLSADEVDEGRALEKEEEQMISQEQVGGHEWKKSQVVKEEEWEKERANHGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTI5</accession>
    <name>A0ABR3BTI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD repeat-containing protein 75 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102436</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614450.1">
        <property type="nucleotide sequence ID" value="XM_066756981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989293"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="10">
        <location>
            <begin position="485"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="991"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1066"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1077" mass="116773" checksum="3226857E71982BFC" modified="2025-10-08" version="1">MAENSQIKPRPERHRHKNRKAIEGDVSSSRSKGKERAIDVNGGVTRVDVAKAGKKRRKRQAPSGLPSLPVGGSIEQQGECSTSRGPRRREDGEHWDSIPIAQNEVTPVPPVWSKDGRFYFSVVHTSIHVHSSTSSNFSRLSTLSSTHPKGHCKSITSLHLSPINPFQIVTSSLDGTVKIWDWVAGRLIRTIDFHGPQSKVDHVAFGQVVGKWWLFAAVTHIKQSSSGQKLAHRLLRTPLGGNSNPILLGKLSNRPASLIMSPRSTYLVALAANKAYTYRMPAPPFKSSDPWEDRPTCVKFVSDQPFTCGAFCPEKTLASATEEEWFATGDQKGVIRLWHGLTQAFRQVDAAASLALGGVVDSTQNPETEKRLPTTSLHWHAHAVSAIAFTPSGSQLLSVGEESVLVQWHLASGRREYIPRLGGRPIVSLTVRKATAAGEEEWWMALADGSVVRVGASSNRLASVGQGIRLDPLRPSSPDTPYPLSVHPSTGSLVVPSSHPSTIQFIDPIASTVLFDLEVVPSNRVSRREEKELETVKVEKIAFSEEQGGKSLWMATMEGREGDEGEGGGMVKNLKMWKWMDDRYLVNTQFPRPHGTSSISSITFSPVPSASGTSSKSVSTPHPYLLTTSTDGVAKIWQVRQSKRSEQGKVTAKKPTIIELYWSCRSTFNYRNLPIRASAFSSDVSILALSHGSVVTLWDVNSNILLKVLDSGLTTDVMSIGFVGKEGRWLIGGGEGKGVAVWDLLSCEVAWSSPSLVVDSLITSSTSAYFVTASNVSSGTTLRVFTPDSSAPLRTISIDTKVTQMVSLSQSSTSDSSSSLHLIGITSTGEIYRFGDIAAAVALESAKSVRQAQAKEGLSIWQEMFGKGAFLEEPEAEENITATASALQQRVSGKSGRPADIFEGPSHTMPPTSMLFDAFMDELLHGNTAMKEGENVKEVTKDEAVVYEMEVDESGDKAEDSTAGEIKGRVVEDEEIRELEAFFKGLLSSVPRAPATPASRKPETLRNGLPSHLMNHTPARSVSTPLLNRKANGDAPRGRASLLVVGNQVDESDIGTPGSLTASGNKKSKKRKAPREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTJ7</accession>
    <name>A0ABR3BTJ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613308.1">
        <property type="nucleotide sequence ID" value="XM_066758860.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991239"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="7">
        <location>
            <begin position="12"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="750" mass="82647" checksum="357187BFE368B063" modified="2025-10-08" version="1">MAVSQSHPNIVDGWFREINTQWPGQAMTLKVKQVLHKEKSLFQDVLVFESETYGNVLVLDGVIQATERDEFSYQEMITHLPMASHPNPENVLVIGGGDGGVIREVLKHKSVKKVTLCDIDEAVIRVSKQWLPLMSNCYKDPRVEVHIGDGFKFLPEHKNEYDVIITDSSDPVGPAEALFQPPYFQLLKEALKEGGSVSTQAECLWVHLPLIKTLKETCSNLFPVVKYGFTTIPTYPAGQIGIMVCTKDSTRDLAVPLRAVPDTRYYNSEVHRAAFTIPEFGRAMLEDGVNVLPKFSGARPTPTSTKKKVLLLGSGLVAGPAADYIARHNHELTIACRTLATAENLASRFPNATPISVDVSSTDALRQAIRGHDVVVSLIPYTHHAQVMEAALEEKAHVVTTSYINPQMRALEQKFKDAGLICFNEIGVDPGVDHLWAIKVFDEVKKAGGKIKSFYSFCGGLVEPAAADNALGYKFSWSPVGVLMALNNDGKYLKDGKVIEVAGKDLMSTAKPYYFTPAYNLVAYPNRDSTVFREFYGLEGVQNLCRGTMRYAGFCEVITAWKEIGLMSDAQVDYLAQGAAPVTWIKVVSQLLGVEAKEAAVIAKLKTLKSFETEARVLISKFRDLGLFSEEQVSQRGSIMRALSALLEEKCAFKEGEVDLVLLQHTFEIINADGSEQTITSSLEAYGDRNGGPSAMAKLVGVPCGMAVQFILEGVLTKPGVFAPYDEETCKLFRERLEKEEGITMVEKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUA6</accession>
    <name>A0ABR3BUA6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614707.1">
        <property type="nucleotide sequence ID" value="XM_066757238.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989554"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="345" mass="39681" checksum="D6F4B96C59EC0937" modified="2025-10-08" version="1">MPSSMTSLAQLNQSEKEADEKRILGRMHTFRLWINKAWDSIPLSKCREACFLKNVLMTSDGILRAVHFIDRTEEHNFLKYTEDVAADGDGIDDLEYDNSSTTSSTSCMTFTMVTKWTVLVGWSMRHGDGSKRCTFAIWTAYECWQIPLRKTSHTTTQIFHLPFNFHRVAWSIGMWCPRSTHIVPDYTDVLSDPFPSTSRLLALFDLQNQHPGLLERVKKHLVLPPCLSEDKLKTLWKCRGGNDCSLYGLKLNRAVSQVRLNGVMEYIDQGKTRWNRQGTTGEVGEDRFDERKWIARFLHPGFSDTFIKWVAFVRPAQAYFYRDIGYPTSASLIEDNLWTSGGNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUE2</accession>
    <name>A0ABR3BUE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614737.1">
        <property type="nucleotide sequence ID" value="XM_066757268.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989584"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="291" mass="32852" checksum="660150F4D9022EFF" modified="2025-10-08" version="1">MIPSPRSFFASWRPEPNIPPDISPLVAAEIAQEYASLRAPNGCPKGIFLVPTEETLLKWHGVLFLHCGPYSGSILRFTLGFPSNYPQSGPTVRFNSDVFHPLVDAKSKIWHPRVNKMKWRQKVDHISRLLHDLKNSFSPVTLDLIEEGEAVNKHVWSLYQHSRQTFISMTAQRAVHSASQTVLYPDVHPQPPLSMTSPRRRQTSMNSLSSDDGFGPSEPVINFKELNIARHLLCRVSRAINFTVFVFEVEAILYSYQSLSKIKPMTYGQSGAATTSSWLDPPITIRRAGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUL6</accession>
    <name>A0ABR3BUL6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alternative oxidase</fullName>
            <ecNumber evidence="13">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_102818</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the alternative oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="13"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614822.1">
        <property type="nucleotide sequence ID" value="XM_066757353.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989674"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0250635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="400" mass="44256" checksum="42E9694A6F1FDE2A" modified="2025-10-08" version="1">MSAIVLRSGNVARFTILAGPSIGGSVTFRSAVLSTRNFSIFTKARIQSDSKSQSSLSLQPRVREAEKSQGPVVGSEGKGVEGPHYQDQVSHNILSDASTTGAWTMFNPIYTDKELNTVQVVGRAPVTFGDKAAHKTVKFLRKCFDFVTGYTPYEIPASVLAQKPIPIAELRSKGKLLSDQKWLFRIILLESIAGVPGMVGGTLRHLRSMRLLKRDGGWIHSLLEEAENERMHLLTFMTIAQPGIFTRALVLAAQGVFYNAFFLTYLISPRIAHRFVGALEEEAVRTYTHCISDMEAGLIPEWKDMPAPAIAIDYWRLPATSSLLDVIRAVRADEATHRFVNHSLANLDQKRDFNPFALSEASPEERGTKWGYTREESAKFALEQQQKLMAASAKSGGLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUN3</accession>
    <name>A0ABR3BUN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614827.1">
        <property type="nucleotide sequence ID" value="XM_066757358.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989679"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="72519" checksum="0E724BF0ED94E55F" modified="2025-10-08" version="1">MLSLLSSRYTRYLPLLLLVLLGTTFLLFERSSSASSTLPRSSVYDYTSPATHCFWPGTDTNDESAAVSDSKIPANKDSVGKMKEWMGWGDSEEVDEDVPSAEAFAWEGQLPDVVPVSGIERYMLAHIEELQQGYDAKHDYEEYGLKLGNISLSAYTAELLETYKEYLLPPGTPPPNPPPSFLPTVLSRLSLRPPITPLPPRPDQVMTTEKSVDDLPWQFQRWKEIMPEWEIKYFDDKALKNWVKGMFGGTKAEEIWMNLPRQVLKTDVFRYMAMLVEGGIYTDSDSMPFDPAPIIHADQWGHPYNHRTSPLLTHLSRILSIATSPHLPSSHPLSSFSPDHAGTTIDEELDVGISTGKSNIYDGPLVDDGAELGQPSLVVSVESDAIDFGWHNWREVGLSRAVQITQWTFMARPGHPVFLDALGRTLRKSEEMARKEKEANKNGKEFIPETALEWTGPGVFSDCVYRYLIARYGFKPEDLIHKKDPLRVGDVLILPAGSYSSVSPFGDEQQRNWAASWHGFFGRWRGADPGVQEFERLKKLKKEAEEAEKKAKEEAEEAEREAKEAEQKAKEAYDQADKSAQEAEEKAKEAAEEAGRKAQEASDTVEALEEEVEKAKEAAVGISDGQDNGSGDFTEIREETEEEKMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUU6</accession>
    <name>A0ABR3BUU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase II assembly factor Rtp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614887.1">
        <property type="nucleotide sequence ID" value="XM_066757418.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989739"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="5">
        <location>
            <begin position="791"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="830"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="4">
        <location>
            <begin position="1104"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="980"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1005"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1164" mass="128927" checksum="E66AAF22FA55EE17" modified="2025-10-08" version="1">MPRSPTPTGHQGNPTLKQILKAGDTLLKPPKPLPSNPPELLPRLRACSKALPKEWKHSVPEWSEDDEMDHVGDNGGLEISEERKKKRRDELVFVVGKRCFAMANAMQTWLEKEFWPKEQRGGLEDKDFLLGTADLRLIRLMLSHTTFSYLLPLTVQYAESLPTILTETADTLAQALEATLKLLKVTTPPAPDAGPSSRLPASPTAITQSLLSSHLIPIFLSTLILAYTPSIPAEHYGPLRMAFLQALMSLTPGHAISSLVNVLKLLVQGRRENAKVNGWVREWPKYPEGIINGLLTAQVRRPGGVRGLMENVLGDTARTDDVTSIEGKRLDHIFNVLVRIPRQVTHEIYYPWLLSELFSMIPLDESSSHHPVAYVNTACYCIQRLWRSNPSIGEWLKNKLHSPWYPKSLFVPADGSAVEVTSWQAIQRSVQNMRLLLIHNPASPDFVDFLVGSILPPLFSLHTFLSLSSQAPKPVLIRPAGSLAATQSRSLADDVSFILASWGKTVEKDVGVMGLWGLVDAGKGWKPDENGVVPDFFWERQDDGVRLMSGSRGTPDIIPEIVFPSFAREELDPDAIAQHIRDQSQAMPDPTLLSKLIKDIDRPDIACQVILRALHLWRIKSAIEEEPSIEAMLHLQLTMKLMTHLGSELFTEPEQLLEWVELTLSGQADRLEDDLIDEETEETNEKPLITEVGEEKGKGNKDDDVPPDGNRGLIELACRLLSAEEVKKALREKDLTILHPILAHLEVISELSPSSSIRLATREATLLLLSIQASAHSTASVNSKKSSKETFDKALELIRDKAVPVRAHGLNMLKDLVYQPHYDIALTPVILNTFMSSIEDDDSFVYLCAVKGLSGMVDALGSEVFEKLMDSYAGMAKELRRLNDADEVDKMLRLAEAVDQVIERTGDALGLYADKIIPVLMSIFPDTSLSTAIRSSALSLLTTCAKASYISLLPWSTDLTNSAIDLIHIESVAVSPFRPGTIQTVERPPQPSWKGDKKPRKVQLVEDEQPEEEDEEEERTVPDPWIEDTDPLAYDDSKHPALRRAAIAFLNWVFSVITFKIMSDHSESTGLEAGEILYKEQPAPGTDADLQGGGFPSGLLERAETVLGYVKSTDEDEVARGHAESAERMLGMLKASVMIRSGGAVEGSGLEDLSESLEKLKVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUU7</accession>
    <name>A0ABR3BUU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102644</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614653.1">
        <property type="nucleotide sequence ID" value="XM_066757184.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989500"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1094" mass="122236" checksum="525BC41B93F52DE5" modified="2025-10-08" version="1">MKSIPTYEHSRQTRYLHLYLAILSPVTYLLFHTSKPQKKSFGRLRSNVPHFPGAQPLISLHQSLALVQRHRQAGNIYNFANASAYTVCPENQQPVVQLEKPTKELRISCDTCRIKKIKCPGEKPKCRNCDQKGRPCTYPTAVRRRGPDKNPGARMKNKVERARQTRKIQGRDQYPSHIVSKGTGLQRLVLPPSKSAPKSAIHDIPVTQDAQEGQHLGVITQRLPILLHSPPISAPPRPSFQNNLHGAVGCRSSDSASSALFKPESATDILLAQTRLLQVPTAASALSALSLASQPLQSVADQVIPPKTERLAVTTQSGYTHQSDPPPIEPSCPNSSNLPQQQLHQAIPSTVTPLPTHDQPSFIPLSTVSQDIATYIPYSADDTISYTTRREPQAFSAHTNMSLVNTGSRPDQLSSFPSHTRVCDYSVLEPTSLFSQPVVSSDINSYGKLPGVNTRVEIWDGRSSSRDTETTGVPPVKDVAIADGNLACDQFSYASGGGATGFSSLALSNDGLALTSEDRNGLSQFRTTSDGLPKAVPAWYDLTPDGCDHPYIASTTMDTLAQGIHLRGLKRKARTPSQVDGEYKMYTPPGNIQAAMDGWWNWILEHYDKDKNTARELVTNACNSFFTNAHIWLNFLNKSLFFTSLFSQTSYSNGPMYKTTSLRAAPHVLLSILGLVTLLQKGHTYEGQKLALLFQREARSILNYCISAGSQDPSLVAAAIIIATFETQPHIEHSTERLAGAVLMLDGIGLSVFSSRLDADDARVSTSITGLPRLKHSAVVATAAGEKEAQLEPSITEWAQVPQWADHWSEGDIWKEEMRRMLWTACSISATLSLWHFMVGKTPLALEISHPERFRLFFPGEMAVIETGDEEQGKTTPWALYHRLIILWHFIVNNQPLHFDCKLEIVRELQAVEDDIQIFIDAGILKIYIWQSADWALLIRRVLGLMDSQALHRWFRNEITFFKELAGGRPGVPQVRQRPLYAWWFVMQVSSALELSRMGKEFWDDSDLIYRMALAGLDQVIKHWNCQNVLGPYFEYLQHKHRTLLEERQRLLQAEAQGRVQDLHLEQLKILRGEAEGRLAKIQCISEYRDSKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV49</accession>
    <name>A0ABR3BV49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614987.1">
        <property type="nucleotide sequence ID" value="XM_066756210.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988514"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="733"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="781"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="820" mass="89193" checksum="996B9EC01E2347D8" modified="2025-10-08" version="1">MIPFRSTLSLTPSDCFPSHNRTTSALSSPPRFLLPHTSASSPSSHLASRLGCTSSSSHISLNREFLSGNEQVHDTACSTPFLPSTPSLVSPTSILSLSSPSPLIPNSSTRSSCKQDTFAESISGPYKLAPPLARNKSNKIIRPPTIPYFPVPSMVFSSHTNYLHAGLQVLWENNGIVDMIGCANTGSSYSAPGHIQISLPALPAALEGKLREVKELRLFMEGKSEFYNDAGRYTPMRLHSCTLELASPSRPLLIPPSDPSHSCSQLQFVLPFDLRLPGWLPSSYENDMTFIGYGCVVEAIIGWAEPVSVSPNYGDPTGAVPEPRGLIKPKSRSVFESVFSSSTLLPSSSKKSVSKWQPFSIRRHRLHPPIGSTIPEIPERHYTLRPEAGSTSPIECVVTVPEFVDINSEEKNLKVSLRIRARRDAIVVAKSRLQTETESTTAAEEDDDINQLESVPMESSDSKCKKEREEPLTHMIELGMEVEETEWLSSTPSRSFRSTFPIPETQPSRYTSQHKLISPPSSYADNHFGFEDRPFKETRTRSCLLSEDGNQRNFFFSNDGLGLTDKWRKVNVVLPMPTEACEMGSKPQPEINSPFLRIKHVLKIRVVCRNADTTEDAQVVLLSTPIRFSTCPTTMPTPIGKPHLASLPSYIQLFHENGELRECDPLPLYTAHESGSQATIPLSEPERSDCSIPAPSYESILPCPSVLSISSIPSSSTLDSASGAASASASVCRSRSGSLSPSGISSSSDLDPLDGDERNLHGRSFSPASQVSDNDAKDLDGAGPSAAAGDSPSGAGQGEEGILEKSMERLVRKIGVDWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVF2</accession>
    <name>A0ABR3BVF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101764</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615094.1">
        <property type="nucleotide sequence ID" value="XM_066756317.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988622"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="220" mass="24378" checksum="ABC40C7A3093B002" modified="2025-10-08" version="1">MSGWMSYFTGRKDTRESARDAIVGLRQQLLMLEKKEEFLQKKIDEEMKKAKANATSNKRLAMAALRQKKAHENELDRIAGTRLTLETQVNAIESANLNAETMVAMKKGADALKGIHSNLTAEGVDATMDKIREQMDLTNEISDAISNPVGMGIVLDEDDLKEELDALEQEQLDDRLAGADRVPSHLPASPVGQTTGRVAVEEDEDDEEAQLRQLQAELAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVL7</accession>
    <name>A0ABR3BVL7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615136.1">
        <property type="nucleotide sequence ID" value="XM_066756359.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988665"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="119" mass="13368" checksum="4E245E4F24FAA999" modified="2025-10-08" version="1">MAEYKEDIEKTGAGAQKIHKIRITLTSKNVKPLEKFCADLINRAKDRDLNVKGPVRLPTKVLKHTTRKSPCGEGSKTWDRYQMRIHKRLIDLNSSADVVKQITSISLEPGVEVEVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVN3</accession>
    <name>A0ABR3BVN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615157.1">
        <property type="nucleotide sequence ID" value="XM_066756380.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988687"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1283" mass="141809" checksum="8AAE003158028140" modified="2025-10-08" version="1">MPSPPLSILQSLSPRIAVLTSEDTMGGWDRESFDIINNTYTHCTPHVPHIISSVVGSRKPEDEQHYPLTRSLLLSSRPVAPYETFNHPVGVLFAISTSTPDPLGTLNKLHARTIGPSAQSLPWLDGHTVLRFYVVVHDVSQMGDNMTPANELLSSVKRAYGPHSTLLVINSQVDRRPVPPSPDTSTHPAIILPRAFTPEDANPSALSQVYASALSSLTLSPMSATSPLMKDDNGELNGSEKSKKLYGSRLTAEDTQRLTALVRELVVQSLVPWMEARVREWNEIYHNNRRGITGRLFGAGRKFFGSRPNSPATNAVGYNASAGYYSLAAVEALSRRLADFEFMLRDYRSAANIYDSLRRDFAQDRAWRYASAATEMYGLSLLLAHSFFSPSNPPTTKPTPFTNLQHTEITSWLEQAVISYHQSGPASQIQIDALRITVLYYEAWKAIREWRGVGAALVKGAGEAEEVPSAVLIEEAAVADIKGGKSGKGKRRSAFHLILAARRYETAGLKKYSRRCLDRASQIYRSAPWTAAQDRIEYSLGRQAYTLGECDTAVEHFLRLLKRENTGVPGSQAGPLQDMALAYEQLCAHPELLESSKSRLQLPTPVFDVKKTRIITSSSSSFESGPSRENWVQLEDQALKSWDRKGKNPVNLLPDEKINIVGTDESFTVELVATNPINAPLFLSDITLTFNPSDSVTVSPVYEITLDPYETRAICVNVIANGAPSTNSVIRLLEVSFKFHKFFPCTQSLERKGRRLQATKAQRLAPIYAADTSLSLSIIAERPRLDVDLMGVPEKVFAGEEVEGVIRVKNIGRKVVRDLKMIWTKEVLIRRKENSDESLTMTIPNRIESNKPSILLPEEIPVGATRDIAVILNGFKQGQTTLFGLITFESVDDGEVATTLVEKRINVQPLLTFKTTIRPVGTSAKEFALALEVMNVSTTEVRVDGIHGVSVLWSVEAQEAVGTLLPNQTLRSIVQIQQGATTADLSQTAVVEALKELIEGQAPDEIVADIQPIVPLSSKMPTDTLPHYFASRNIHRIAYLQEQFPTISAVFLPDLFPLLDPLDLDLVLSCTIRFPDSLRKGRLVAHSLRPGPSFSVVESLRRDVEAAMAGGSKQTRTMYEETGRLRRVLIASVLDGCLGREEDPVEVTIKVGEDNGLIEHDFKTGACKVPVAFTIRNRSPVLPLRFVLYLPSPSPSVPSIASEPSTLIPARFIGNLIFRDTLKSGETLVLNSAVWVYVAGLMNLKDWKLVVETGEIGVDIEEWLPRKVWSKKGYEKVIEIRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVS2</accession>
    <name>A0ABR3BVS2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615218.1">
        <property type="nucleotide sequence ID" value="XM_066756441.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988748"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="751" mass="83174" checksum="51DEA22DE0BB180A" modified="2025-10-08" version="1">MAAGLAYDLVLIFWRIVINIFFREIRPRGAFNIPREGPVLFICGPHANQFLDPLLLFSETRKEAGRRVSVLTAAKSMNRKFIGAVARVMDSIPVARAADYAVAGKGRIILSEADPLIVTGIDTSFATQVKPRSQLMLPKSAGYASAPVAEVISDTEIRLKSEFVVPSKDGSANVKASHRVRNESESKEGLQFKILPHVEQEDTYGACFQRLYEGGCIGVFPEGGSHDRTDFLPLKAGFSIMALGAIAAHPGLDVKLVPVGLSYFHAHKFRSRAVIEFGSPISVDPELVELYKQGGAKKREACGKLLEQVHDGLRAVTLRAPDWETMQVIQAARRLYRVPGQHLTLGQVVELSKRMMEGYLTYKDEPKIIDLRQKVIAYNRLLRDMGIADHQVERASSRSVKSLLLLVYRVGLLLWWSILALPGALLHAPVFILAKLISIQKAKEALAASTVKIQGRDVLATWKVLVSLAVTPLLYIFYSVLATFLAYKYDLAPEWRHWTPVIIFCWLPGWAMASLKFGEAGVDVAKSLRPLFLSVWPYNQSEVNRLREMREALTNEISEVIDEFGPKLYDNFERGRILPSASVPQTGRTPGLLSRKSQTADSSVLSHPMLWLDERIFGWNRSASVGQSIWSSSAANKQPESETAPASPYDSEGEEEEADVDYDDVLSIIDTRRSNVRLASPKGKKRRYTGQARSEESAASPKSDLEGVPLPRADDNGAIKLHKRSVPAKEGTSETNEEEGLGLDTGREKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW92</accession>
    <name>A0ABR3BW92_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102047</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615375.1">
        <property type="nucleotide sequence ID" value="XM_066756598.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988905"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="353" mass="38100" checksum="F74B093FB52A07D2" modified="2025-10-08" version="1">MYYDLYLPFPLPPSQEDANPKKAKKGKGKAPLSPVVVSGADCWDGLETSTRESIAKRIALTGHLGYSVVGCTIAPGEPSNQVLPSPFQRGPPYPGLDPRFASRSGASPSSSSFGKAPLVQVTRYHIRLDDGKAHCLTAQNTSALRNYDILSVSPTTDKSFQLACTDLSNPGPNQISIITLPLHERAFTFRFNRKQMRQAQRNGVVFELVYSAALFPPASTPVEVARRFRQNFLSNAREVIRITGGKSVIFSSGPGGSENGLRGCLDVVNLGTLIGMPANLAREAVDKTPKMVLLRAQSRKTFKAIMTMPVLAPPPLAETDTSMGDTLAADVLNKRAADDTTKDAVVKRSRVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWB6</accession>
    <name>A0ABR3BWB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615385.1">
        <property type="nucleotide sequence ID" value="XM_066756608.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988915"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30801" checksum="8A23C1AA980F871C" modified="2025-10-08" version="1">MPAIDPHYLWALGHFTVLFCTGYIILQTVLFRGTPVKTYKLAYSGALLSYFIVVYKSLGRPQLSQPWLRRALVDENCQYALLALFWWISKPVNLTVLPFATFSLFHCLTFLRTNIIPKLVPPSPKPAEGAAPGTTAGATAPQPSRPPALLDNVSRRIQVWVKTNYDTAMRFVAYAEIFITLRLFAGVLTFRTSFITALFMIHFVRFRYHASPFTRSAVHEITARIDAFVAGKGAGVQNAWGTVKRLVVTWGGMPLLPNEGRNGAQGPTAQAQQAARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWI7</accession>
    <name>A0ABR3BWI7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPX2 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615457.1">
        <property type="nucleotide sequence ID" value="XM_066756680.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988987"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1243" mass="138367" checksum="D0314B841A8B535F" modified="2025-10-08" version="1">MTRPIQSRAAKGRNKGTSDRTAQTPKRTNQLSTARAQQLPAIAQKVTRSSARLAARTQPDQPHQKTVTAVHEQVLQSISTGCGKKNISRFISASVLAKQLSVADIRKPETASLNAPEQGGYDDRGFWREPPSPAEHSNSRKQRPTVGGDTVKFHLSATAATPIIASYRRRHLSLPSSSSSSSSSSPSPPPTDLRTPHLQNLINKKGTNGCKDNRFFCTQGYTPSSKVIGDLFRTKSLAPPPQSLSHVDVFQPPSNVTAYQEANILPFSSSTQTADTSEIGHQVEELSNEDEQSPIKPPTSRRSRVRPVESKSYSVSDDEGEEERHEEGREEDGGDWQPIQPLSLAQSRSIPLSNKWRDPFSYIPAANTQSAAPLRSHRRNQIRPSSTVLDTPSELVGDEEPTSQTKFDCVEKTSETPLCNASSIVKVVKVTSISGNITYGKGRSHTYKAGLPDPVPNGRLTSLTPLAHSFSTHNPSAINLPRKENALDVIRVQESLNKAPTRPAGDHTEEGEDELWSDDWPGDLEESPTKRGPLRPITMVLGKRPPRKHAVESDNGFNYDTNNRAQKKRRIEFPNEAASSPVHDTPRLRLSRNESVRIRVQNYIQVVHSVRPKRCRRNASRHIRPPAGYSFKPFEAIPFSEYVKEHRKNPNITLFQMPTGLFSSGYIARQHASKKILGRITRHKTPPALDPSQNDPHWEDEIVLESSTRPLQARCKDRSEAEALAKRIPRLNVITDPDRHRSQFQPLPGRSPQRKRPHLVEDACRKVPVLDSVARRDTSHQTNTGPMKTAHEEMKCEKVESPLLLALPPRRTVLKDTGYWKIPQQGQLAKRINPPKRSVWPVQLRRQESIGQFPSPASVSINLSLSISGNSTQERQTLASQCLNAEDDFADRRMMSGIDMTNHLVGRLNSHSIQNRKKRQEEREKRVQEKREALRKEKKKDTDARVNEAVQRPSQKVSVPVTSNQSHAIIPLPHAKSSDTQGTTHSRRAVAAPGLSRDLVRSSTQVTPLSAHPTPCRIGLLRRKTMPPSPSFKKNHTVTELGPVRPQHSNMVATPSKACALLTQLNTQHNTGTSFNIQSYPPLAQASRHLGTQYTQVLERTEVDSSRTRPTLNLERTEVDSSSQPCFIQGLEKTWVGSSRPQFRTFSFGPENEQAHEIKDALFSQGTPEISPSPPPATQALSRLRSRSIGRRPIGLRAPPSPQKTPVSQQTKSQGTQISGVYSQFRSPLKNTSGTPRRTDKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWJ4</accession>
    <name>A0ABR3BWJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIB component B'' Myb domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614655.1">
        <property type="nucleotide sequence ID" value="XM_066757186.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989502"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIB component B'' Myb" evidence="2">
        <location>
            <begin position="466"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="642" mass="71037" checksum="65D65A22CEC00303" modified="2025-10-08" version="1">MSLRLPSQNKFRPVARAPPPRKLPPPRHSLSLLDAAARPSPAPAPPPPPPQPESPPPPPPQPAGFPPTLATALASSPPPLDPVLLAEEAVAAIPPTLPPPAPEPAPEIRRRAPRRRRVVPAEAAKKSGKTMPMAVANGSGTAASTPRASDDDAAGPKRGVAVLDLDDEASAPGSVAPSSRAGSLAPAGGRIKRAKKSHGPRVATIALVDVEPEEMVGSPVTEQTTMGDLATVLVSEGRVSSRAIKIDEFRRAEMLQKKQDAQKRAEDMWRRNQIKRRKVRAAQNKERARRREQIRVSGGGEMDDVSPDEMDSEEEFHVAPDRLTPPRSSSEESHHPVAAPDFHQDDEEQVDQADEEFENMFDNNARPDDQDVNALQEEDEQDDEAMAALRAAGFTITDDPASRSDDDDDDDNPWDDPNGGMGETFDVADYRLALQERRLEEFRQREQDDGDVVEVDEETRFVNSATYGKNRKSQRWSKMETELFYEILGETGENYTLMKAYFPGRDIRSLRLKGARENKVNPEKMTAAIMARKPLDKDYLAKSAGYDAGRSWDKEEALFEEAKANVERLRKLDSEQPLGKDASHQDQDQGLDEPHRGGDMMGLDDDEQGLQRIEEVDVDVEEEEKEEKSEDENDEDQPDEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWR2</accession>
    <name>A0ABR3BWR2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615547.1">
        <property type="nucleotide sequence ID" value="XM_066756770.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989077"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046184956" evidence="3">
        <location>
            <begin position="21"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="194" mass="20117" checksum="0346B5095A1B13AE" modified="2025-10-08" version="1">MRFTPSAVLATLFLVTSVFAQRLTTTLNVQDGDTLVISKTTNALGATITTTLSTIVSDGVTTSSTSTSSAKRKTTTTPRIVGAETTTTSTPPPMRTTTYWVDTGNGYWTYYTWTAPTTTVPTVATANVPAGTVQNYNDYQSAVNSAVFSSVQEAIATSNNAGARAQPVGMDSILGGWMTLVLGAVGAGLGVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWS8</accession>
    <name>A0ABR3BWS8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615321.1">
        <property type="nucleotide sequence ID" value="XM_066756544.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988851"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32536" checksum="CCB3FB49BD3D43C4" modified="2025-10-08" version="1">MQHQHRPPQEIYHPPQPPSIPLPTINTLIPRLTTTINDIDSLKTLVANGAHNGTIPSWDVLLQRYSLLLGRINALSATITASPARPSVTGYSQRPSPQSPILSHYLVHPLTPLPPPDSAGSEITPLVQDAFFQAINTIPLVAAPADDSIEGMGPNVSSSHTHTQDQLRALSEMDLEDLRRRILLIMERDGTKVKAMKEEIERRAEEVDWAMRVDEAEEGDDYEDDEPAAAPTKDKDEIVDDDDLFGSDEDESMEAVPAADTASARHSKEQQTSVSRATWKVTDFVKLMDTGTQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWV1</accession>
    <name>A0ABR3BWV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cdc23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615588.1">
        <property type="nucleotide sequence ID" value="XM_066756811.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989118"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="14"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="392"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="426"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="626" mass="71737" checksum="720BB59B2F45925B" modified="2025-10-08" version="1">MPADIPPDAKIKMANDLRKAIRELRDRGLMVAAKWASELLMSLPKEYRSTSNLVFSPPPQISSLPPRSPPGHARPSIGDFLPSPGPGAFAQAGPSHGRTMHGIEIEEEDDVIEEDEFQLARGYFDLKEYDRVAWVLKDGQGNRAKFLRYYSMYLSADRKAQESLPHFLDTKEERLALYPALSSLLSELKKETDPYLIYLRGLCYMRLDRRPPAVKCFMDSVKLKPYNWSAWSQMAQLVSSADMFISLKEELPSTPMLTFFAINCMLDLHTATNLVMNMIKELLEIFPSSVHLKAQRALVYYHMRDFETAEDEFDAVQRLDPFRMEEVDIYSNMLYVMNKQAKLGKLAHEYAEIDRNRAEVCCLIGNYYSSRSDHTKAITYFKRSLMLNREYLPAWTLMGHEFVELKNSHAAIEAYRKAIDVNAKDYRAWYGLGQAYELLDMPMYAIEYYNQATSLRPYDCRMWTALATVYENLHRLQDAILAHIRALLGADRVQTMTILLKLASLHTTLDEIHKAVGYHRKVVALGEKSGLEVAEMAGSYLAVAEWEMRGLIQLQRRDAREGKNLDRSNWDGDDIMDGAGVLKEADLAIAAQYLERVAQTNAPQRDRAEELLRSLRVYEMRTVATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWX3</accession>
    <name>A0ABR3BWX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614538.1">
        <property type="nucleotide sequence ID" value="XM_066757069.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989381"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="162" mass="17877" checksum="DEBE63468F588B8E" modified="2025-10-08" version="1">MNQPNRVDSWLLQDDEKPLTITEDPKLPNASTIVIRRQDHTLGNMLRAQLMLDPTVLFAGYKVPHPLENDILLKIQTDERSNPAEALKRACHELIRQTVHIKSQFQQQAKNIEMGMGPEQGVAPGAAGANGAYDPYGDGFGREGNVVVGGAAREQGQDVYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX95</accession>
    <name>A0ABR3BX95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615642.1">
        <property type="nucleotide sequence ID" value="XM_066756865.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989173"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="91" mass="10194" checksum="AE7089C02407FBA4" modified="2025-10-08" version="1">MGKGTPSFGKRHSKSHTLCRRCGNRSFHKQKLTCAQCGYPAAKLRSFNWGLKAKRRKTTGTGRMAHLKNVNRRFKNGFREGGAAAKKTKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZE6</accession>
    <name>A0ABR3BZE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615737.1">
        <property type="nucleotide sequence ID" value="XM_066755451.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987746"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="3"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="122" mass="13728" checksum="4861AC23F98F1FFD" modified="2025-10-08" version="1">MPLYLCLCPDYPNVFERRLAAREAHLADSKVSREAGTTLFGRAYMDEASATSNSRLKIQVPPGQIGSGTLGSTMLYRFPTIEEAWERIKSDPYWVQGVWDKDRVTVNELAYLPTDGTLKLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZP1</accession>
    <name>A0ABR3BZP1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Carnitine/acyl carnitine carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_101236</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616079.1">
        <property type="nucleotide sequence ID" value="XM_066755793.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988094"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="118"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="225"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0253858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="33066" checksum="CBBF8F515834014F" modified="2025-10-08" version="1">MSDDASEIEAVSRNSGKQTVDPVKSFLSGGFGGVSCVLVGHPFDLTKTRLQTAPPGVYTGAIDVVKKTVKADGFRGMYRGVTPPILGVTPIFAISFWGYDLGKRLVYSFSPDRTEPSLSIPELAFAGAFSALPATLVAAPAERVKVLLQVQGQNGAQAYNGVFDVVTKLYAEGGIRSLFRGTVATLARDGPGSAAYFATYEYLKKMLSAAPETLPDGSKAPAPPLSVPAIMAAGGGAGIAMWSLGIPPDTIKSRLQSAPQGTYTGFMDCTRKLIAQDGVTALWKGFGPAMARAVPANAATFLGVELSLKMMDKMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C042</accession>
    <name>A0ABR3C042_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616229.1">
        <property type="nucleotide sequence ID" value="XM_066755943.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988245"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="64"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="848"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="867" mass="93767" checksum="4A83AFE112EC2460" modified="2025-10-08" version="1">MPLPSIHPLPPNPTTGYQPLASLGGTRSTLHPPPASTSGAGVSRETLKSLQDVYWSDDEDDPDCLLCAEPLDLSDLNFKPCQCGLQICQFCYNKLLDTDARCPGCRRPYDTKAVVFQPVDWEEVKKAKEKKAKKAKTIKQLTAIGRRHLLGVRIVMKNMVYVVGMKLPAIGDEALSVLRSNDYFGQYGKISKLYLADTKPPTSVPSLGSDNSETTGIYIVYIRREDAARCITSLDGIPAPQGPPGAVLKATYGTARYCEAFLKGVKCDNSNCHGLHEWGGESDTFTKEDMEIALTRPSEYDARQKQQNQAQPQQTFPSLSSKIAWPKPSGEDGHSALSATGLPSAASWGKGIGAKIPGRGSAGAIARPTKINGLFPLSKNNAAFPLPTPSPTVPIIIKEKKEKKSAAMARARSTDSTQSATPSSNQTSPKRKSNALPNLTTTKSTASSAPVPPLSQSVLPSVSAATPSSPGPALEPEPVSEGTDGSADEHLSAESDAGPSSESPAPQTPAHIVENIPPPPVSSEPIIIHSPYPEPVIFTFPADDKDFAFVLGLDDGELQRMQAQAEGYEPSPFSKTLEGLAEIGVHAPEIPDLFVAATPPPVDHYSGLFRPFETDEPSPAMSNNTPGTSRVSEDDHNAQRTESRFGFARASVNVTAQSPFSNARRGAADPNLRDGWYRNNDASLSSHAQHDANNGAFTAQMSNNFSSSYDSSTGVTDNGWNGESVYNASPSLQRQNVATVGLHGYDVRPNGRLEQTLLQGQYVQKGMRDREGYDNTLLAMLQYGNPPQLFSSQHHHQQQQQQRAIFSPDSTPHAILEDGPFQSPMAFSHLQQAQQTPLQHHPDARQLMQMHQRRSQSPAPTHGYRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0C4</accession>
    <name>A0ABR3C0C4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616085.1">
        <property type="nucleotide sequence ID" value="XM_066755799.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988100"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="737"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="857"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="913"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="984" mass="108107" checksum="968AAD363463B3C6" modified="2025-10-08" version="1">MQSGPRMVMPSAPHIQHPGMNPPMDPALQQQMMVVNGAHVNGAQRVPFEQQTMSDENRAYLEQQVRLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQQGREVKAATQRSLGVATQQAPRHMMPHPQMVQSLQAQGIRQVLTPQGAVVWLDAQNRQVQINQAWQNDPRQQQQVGQGQMQALYQQQQQQQHLQQQQLLQQMQQQQVQQQQQQQVQQQQQMMPPQQQAQLQHLQRQQALAQQAAQTQQRASMPPSARPPPAGLPTPSLLQVPPPPSMKRPVHDMSRSASPMPPHMRMQQSQPSQAQATQMQPSLSALPLTGNSPALLPLRGPPIPVSMSDSHIAQNHPQQVGQSRANGLQALPQIPPEPPMRWSKTLILSSQNRLERWKQKTAKLETMLADAKLGLAEMEKEAKEGNKRAEERSHDPQGMFDKEILTYLKRAGYSNAAQALEGDIKDAGRNVEGKPGSPSGSSPKTQSPRDVKISSTPVSQRVSATIKDDPQGSDSIFGRGEGDEKMELDKNGEDRSETKDLGELFTWWMLYQDTRTLLAQKPHLFQPPTSLTSSHSANTPAAGNVAFPSMTARTMSQANGVKQEDTLLRLQQAEEMKQAQQAQIAAQQEAPRRTLKRKRESEDAQMGGKFSKVGAPTPEDHRRQAVELSRSASAQMTPQQSQMNEISQSPATQTPQDPTRHHNLAEAQRVYAATQAAYARQQVERTSVANSPANFSIGLSPVQLGTPSIGNDQSPAVAHEADGNSNVNGNTVDRAPTPASAKAKKKPARITVDTEVGDAADLDAPQSGAASATSKRKTPSTGKRPLKSATVEKPTKGKTKTKAAKSPYGTQPTGDAIRPEEEGPAQTPSGQVGQTPGSTQSTVYPLPVQTPSQEQPTTAPPGEIEQDHLESQAALPPPPTQIPAQTQTQAPQNQNTGFEAPFEFDDSNELFKMLDFNDGDGGGFDNEVFNFEGFAFPSVGEGQEDWQAIDSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1L7</accession>
    <name>A0ABR3C1L7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_101617</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasmic vesicle</location>
            <location evidence="1 12">COPI-coated vesicle membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="12">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616457.1">
        <property type="nucleotide sequence ID" value="XM_066756171.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988475"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="15">
        <location>
            <begin position="320"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="16">
        <location>
            <begin position="598"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="832"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="850"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="888"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0254236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="908" mass="99736" checksum="90E312D5CB8A0250" modified="2025-10-08" version="1">MPMLLDITRKLLARSDRVKSVDFHPTEPHVICGLYNGQVKIWDYETGTDVKTFEVTDVPVRCVRYIARKNWFVSGSDDFQLRVYNISTGEKITQFEAHPDYIRCLTVHPTLSLVLTGSDDMTIKCWDWDKGWRCVQIFEGHTHYIMALAINPKDPQTFASACLDHTVKVWSLGNSVPNFSLEAHEKGVNYVDYYHGGDKPYIVTTGDDRLVKIWDYHSKSCVQTLESHTANVSFAIFHPSLPIIVSGSEDGTVKIWHSSTYRLENTLSYGLERAWCVAYKKSGNEVAVGFDEGAVVVKLGRDEPAVSMDTSGKIVYARNTEILTANLSTLSENEPLEDGQRVPLPLRDLGTTEVYPQSLQHSPNGRFVTVCGDGEYIIYTSLAWRNKAFGNGSSFAWAGDSNTYAVQEGKAKIRVFRSFKERPNLLKSAGNWAVEGVHGGTLLAARGNGFVMFWDWETGSVVRRIEVDATNVSWSATGNLVVITAEDSFYVLSFNREAYDAKLDSGELIGDEGVEEAFEVIAEISETVKTSKWVGDCFVYTNSTNRLNYLIGDQSHTVNHFDQGIYLLGYLPSHNRIYVADKDMNIYSYALSVSVVEYQTAILRGDLDAAAEILPSVPQDQRNRIARFLEAQDLKELALSVSTDADQRFDLAISLDDLETALTLVRAADESAAASAGDAAGVGAGVSVNQAKWKVVGDKALSAWQMDLAKEAFQNANDLSSLLLLYTSLSDRTGLSSLAQVASQKGLNNLAFAAYLQLGDVAACIDLLVKTDRLAEAALFARSYAPLTKGTEKEWGATVKLWKEQLVKDGRGKVAEKVAEPEEDGELFREEMEAAAQGSSSSTSLPSVAEPKENGELVKEEKETAKDSTASPPSAPIAKVVEEKEAVVDSTASPSSAPATKAKKKKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1W2</accession>
    <name>A0ABR3C1W2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616336.1">
        <property type="nucleotide sequence ID" value="XM_066756050.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988352"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0254115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="520" mass="55181" checksum="FFEDDC59CAA95D12" modified="2025-10-08" version="1">MSSTHIDKEATLQQLAASNTFDTDWPTLKGYFQESLNDSLEIFLTKGPPRPYRPRGASPPPLGASSKLHTSLPSVTSDEAGKPPAESLLLSPSHTAATLRHASELAHDPEDLRPSTIGGLVIPPFPPLDPSRRRTPSPAPMQRSPSPMSPRANGMHSQRVVAMGIGVPDEEWDEETVIGGKKLQGWLDEAQGKAEIQRLNNLLDDMDAPPFTIQRLAELLLHPTSQHTTLGKFSRAIEKSLLVTSPWGAPSYVYIPPSSFAAHPGVGPISSISSPSSDGGPESDSTMPAGSTTPLFSPIPFLVHPSHNPALAIETGHPGASMNTDEGLLSPLDLPEGKIPSSSDRSPTPEPEDSTAAPSGPSINDIDAEMVSPGDISRPENPQGTSDPANTSYMGRVDELDTGPLPTSEQVSIKRRSSNSSSSSQMEMDSRETVVMAGQGEGGQLAPHGMADKPMPLSSTTVVKDEPEGGRVIKGLRRSESEKSLRERFVSGGVQKPEEAGLVDNTEGISKSAETKEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3Q6</accession>
    <name>A0ABR3C3Q6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal RNA-processing protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616345.1">
        <property type="nucleotide sequence ID" value="XM_066756059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988362"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0254124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28248" checksum="2BD81F137191F4A4" modified="2025-10-08" version="1">MPPTKAKSNVALLTEGAAYIQRAKKARKEQVEEIKFDDEARREWLTGFSKRKKAKAEEKKARAKERERQEHLEERRNARKELKQRAAENVKSVRRAMGLEDDEDDDEEEEEDSNEDGGPSASKDQEEAEFSDDEQIATVTITEDFDPSASVYPIRTSTSPSPSANDKSEPQPRKPAVKLLPPSSKRAQKADEKKKEKKKISRSMETKAERRKGKEMELRKRSKKAALAMERKGKTPRGPNKGKGKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3R0</accession>
    <name>A0ABR3C3R0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616524.1">
        <property type="nucleotide sequence ID" value="XM_066754623.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986902"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="106"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="459" mass="51482" checksum="F38752379560B246" modified="2025-10-08" version="1">MASVVTLPITLTAAPAGYSKPSPSKPSAPKQLPIYPAGPSFISAARRQILQRSFADDDKAVLEAREREAEARANASADGSQYPGLGEEEEPHTVLSSDPKEWKKQDHYAILGLGHLRYTATDDHIKVAHRRKVLRHHPDKKASQTGHGTNDDSFFKCIQKAHETLTHPERRRQFDSVDWNINDEVPDFKKLSPEEFCTQANALFAREGRFSKIQPVPEFGDLNSPKKEVEDFYHFFYNFDSWRSFEWHDKEVNEGSDSRDDKRFTEKKNKSERTRRKKEDNIRLRELVDSVLALDPRIKRIKAEEKAAREAKKKGGAAGAPKQLSAAEKKKLEEQKKKEEEEKKAAEKKANEAGKADREAAKKAKEAARKNLKKWKKAISTVIASSNYFQAEGTAASAQVIEKQLGELDALVELLEPEQVKDLKEKVEKAGSGAPVKAALQEKVAALGEKGAGKFTEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3Z9</accession>
    <name>A0ABR3C3Z9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616633.1">
        <property type="nucleotide sequence ID" value="XM_066754732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987016"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="4">
        <location>
            <begin position="304"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="3">
        <location>
            <begin position="495"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="5">
        <location>
            <begin position="720"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1023" mass="114921" checksum="5224B15914C7B531" modified="2025-10-08" version="1">MTVLLAFPAKWVTEAHTLIGSLAFAVTLFIGWASGLWQPLCTNSVAKWPVEWFPSVSATIGDHAPPRAVFHILIALCATPRFLLLLVQWLVHRNPPCTSGHSVDVKSVKRSSATLVDIELLVGLARTFCCGGWVYITSRDHHDLHDLFMIFYLLLTVPWMFLSSENAKCDSQHKRRVPFYGFLATIPPMMWFYYRHSALRIPGAYTYYSMFEWSLVFWDIAFDALSVLELNHLKIAFIDISSPSSKVGIAENAGQSAFYLVKPSVLEHLEDEIQVDWTSQVVGEPSPAWRQAIAWFSDVYFAICFWTVFTGLGFQLFYWSVWKLALAGSEFALAANLAGYLFAFKSAHRYLISRDGQITHRIVTVVCGMGCYFFPWPAARLLGLTIGTWAGWSAIFGTWTRVKGSQEMVAEGQIIGLGMVVVMLLKYANKSINPFWCLVNETSGGWNKTGLVLATICLVEFASRPADLHPASPLVDSSAKKTEQQIPMPHPTKMHTRLITVGLGTLIHLLQTFMMDAGTVISWTWTGYPIKGPTLHPHAGFVIAAASAGLIAPRFALTPAWSLFGSISAYVLYSYPNWIGFYGGLGLTTYLTSIIPAYIRAASACNPATTFGNALLVNIVFDVASVVTTAYAFVPLGWTLRERTDLILGGCMLATVIGSRASNSLALPTASKAPLRTQRRTRAVAHLTLIATVFLSIFSIIFSYYRVPTEKPVPYYPKHRIFSGGIWTVHFGVDKEGRDSQRRMQELVKDMQVDVLGLLETDLHRFVYGNRDLTRAIAEDLGYYVDLGPGPNKHTWGAALLSKFPIVKSSHHLLPSPHGELAPAIFATLDIHGQEVNVMVSHNGQEEDLLDRELQTTEIARILRSTASTPAVFLGYLVTRTGDRRPWPYQILMEDGKMWDIEIGDRWRWCEYIAFRGLWRIAFARVHESDITDTELQVGKFMLAKPGEQVIYENNQELYWHIGENDIPQPWRMPNMFRGKGVRGHRYVVWDGPLYYMPPVQSQLRGYGWDWSNDFETAAVERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C421</accession>
    <name>A0ABR3C421_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">DNA repair protein Rad5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_100178</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616651.1">
        <property type="nucleotide sequence ID" value="XM_066754750.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987036"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18071">
        <property type="entry name" value="DEXHc_HLTF1_SMARC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="298"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="648"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="720"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0255374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="99393" checksum="B5AF87423C7A5614" modified="2025-10-08" version="1">MSHIDYFGGQSSTTQKRRRQTQATSSQGEDDDPRSRALEHDEHFATFRSDVVGVQYYRGLVGRGEYVLLRREPTNKWDSNAVQVINAGGSQVGHIPRAVAANLATLMDRNQICVEGRMVGQNLDGAKHFKLALDVSIYLNHSTRESLESALRWVSPGDRVDNQAPRPVYMSQSHVRGTAGSSVGLPQSVDNNMKELLEGLSRDNADLRQVDKVMDALTSDVDVSKLPLHPAPPGTANGQLLTNLLPHQSQALHWMISRENPQLPKSPADPAVQFWVKQKGVGNKPDYWLNVATKTPQSEVPQLGRGGIVADGMGLGKTLTTISLVLATKNDPVGDKVSQSTLIVCPLSVLGNWEKQIRDHVAPSQLTFYTYHGAAKGLTAKKLGGYDIVLTTYQTVAAEDGAVPDIEDTPLAKKPRLSTKKAGPLATINWKRVVADEGHQLKNPKAKMTVAFANLSAERRWVCTGTPIVNSPNDLGSLLTCLHICAPLSNPQYFRALLLRPLSRGDPTASKLLQAVVSQILLRRTKDSKGANGANMIELPEIEFFRVPVNLDDETRKVYEEVLEHSKRRFEETLRTGEGAANVLSMLTRMRQLCLSLELVPQSFLDEIRAPPKFQNGASPTSIGSLSNEAKDALVKKLRQFVEDEIECGICMDEVEFAKDPAITDCGHPFCLPCIERVITGQGLCPMDRHPIAHGSILRLPSDEDVYIPSSQAQSINSPKIDELVKYLRIFQRNDKTLVFSQFTSFLDCVGVRLEEEGIKFVRFDGRMSGKQRTAVIKTFQEPVKGDDDEKTPKVMLISLKSGAVGLNLTAASNVFLCDPWWQSAIEAQAIDRAHRMGQKKVVRVFQLIAENTIESSVLDIQKRKDAMVAKAFEKSSKESQKTKKEARFEDIKELLGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C429</accession>
    <name>A0ABR3C429_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616662.1">
        <property type="nucleotide sequence ID" value="XM_066754761.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987047"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="504" mass="54153" checksum="D46C2BFDFC44E850" modified="2025-10-08" version="1">MPTHAKLNVPPLGEVEVPVGLFINNEWVESISKEIFSTVNPATGQKLLDFAHAKKEDIDKAVIAARKAFKTTWGNNVPAAERGALLNKLADLMERDSDKLAALESINSGKGIRIAREADVADSIACIRYYAGLADKIHGQTVSSFGKEKFVYTLHQPIGVCGQIIPWNYPIMMWAWKIAPALAAGCTIVMKPSELTPLSALALCDLVKEAGIPAGVVNTVPGLGATAGDAISRHMDIDKVAFTGSVVTGRRISIAAAESNLKKVTLELGGKSPVIVFDSADVEEAADWAALAIWFNSGQDCCAGSRLYVHESIFDKFLAAMKKRAETCAIGQPHDEKTSFGPLISEGQRDKVLNYILSGKEQGARVVTGGQKWPKSNAGYWIEPTILADTTPDMTVVKEEIFGPVVVAAPFKTEEEVLELSNDTAYGLAAAVFTNDTRQATRVSAALDAGTVWVNQYALLHPGVPFGGFKQSGIGRELGTYGLEAYMQIKAVHNNLTQTSPWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C497</accession>
    <name>A0ABR3C497_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100256</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616729.1">
        <property type="nucleotide sequence ID" value="XM_066754828.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987114"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF18">
        <property type="entry name" value="PEPTIDASE M48 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="452"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="707" mass="79406" checksum="50D39976DD117504" modified="2025-10-08" version="1">MPASITKTLPFITTTTVSTSRISTLSFSHLSRPPYSHYSPRFTSTILHGKGNNKARNHCTASLSSSNPLSTLQLLNHARYRIAEHHVLPRSFHASARRDAIPLIPVGISVVKGASVLTAATAFSRIVISFLPIGTIAAFKMIRLGRWIESGVECPTVSPQAEEFFKMWCEGEKSIKLKPEEANALVESQPDNHGGLTLPDGRVAYSMPLPPSKFRHSSHQDPDNRFDVTPKMLMEHFRGNRRKVAFVIRRRYYIIPPLPPSAEAYYNSLESKQQAEIVSLRRYWLGLKTFKDCFKWGRWFIAIVFLLPFLLICGAYIAGLERVPLTGRWRLILLTPEEEDAISTSLAGGNWYRSVINLLTTPERPAPPILPTDDWRWAWVQSVLTRLETAALIECQLIPSEQKPHKEYDSPLPLPPPTYHPFKPRPRASSLLHSVLPGGEPNTGREHLEVGPPYNIMLLQKDEQNAFSYGFGGKKAGGIVVYTGLLDEILRHSSPACQRTPQIETPQSGFLSGLFSTSRTSNQNKQHHIQPTEEQNLHLACILAHEMGHLLLSHHLETLSQQQVLWPSVLGFSMDLIRAFIWPLTVFLGPTVNDALANMGRTSSEELADKYGEIGFQWKHEYEADLAGLRILARAGYDPRAAVSHFQSSVAGLHEIQPDDKADNNTFTGAAFKLWTKATHPSAEQRTDAIRKEIDRWQEEAKKTKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4A8</accession>
    <name>A0ABR3C4A8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616719.1">
        <property type="nucleotide sequence ID" value="XM_066754818.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987104"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="138"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="461" mass="49765" checksum="E8CB5F3D00E73C3A" modified="2025-10-08" version="1">MPSTRSKKARSDPAPDMPVATRAASTVIATIAAAKRVKRASGALPPSAANDHLESSKKKQKLEPRSIDITPPSTALDLPTVPQPTLLPPTLNFDLLSAISHLSALDPRFSFFFEHLPCRPFVNLEAIDPFRTLVTSIIGQQVSWMAARAINTRFRALFGFTHEREGFPSPQMVLSQDVASLRGVGLSGRKAEYVLSLADHFASGQLSTHLLQSGTDEEISKALIAVRGIGQWTVDMFMIFSLRRPDILAVGDLGVQKGLIKWALAAHGALEKKSSGTITPKKTKGKANKDGQKEVKEEVDDKGEGELDTNIRESTPVSHVPSSSAPPTPMTPNDTTENPVPKMGALHTPAAPSGTSVSHIPPTPSTPSAVPRETVEVPPRTLPTLTPDVMLTAPLDHPDWDAHRAAPLLEGLTVEILKSRLNGKKVKGGAYLTPKEMEALTEGWRPYRSLAVFYMWPVAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4H2</accession>
    <name>A0ABR3C4H2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616533.1">
        <property type="nucleotide sequence ID" value="XM_066754632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986911"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="121"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="414" mass="46295" checksum="924469C868F1F7E4" modified="2025-10-08" version="1">MSFFKSRSASASTASLRSENLGPKTTEILTLPHQESSVKKKWEYDDHQLNLIAQLREYTKTIALPESDEYYPWEQRFLSDPATHARYMRAAKWKLHDAKHRIKGTMEWRREFKPELIHPDDVGIEAETGKIILTGFDMDARPILYMRPGRENTETSPRQIRHLIYHLERAIDLMPPGQEQVAIIVDYKSATSQSNPSIGTARKVLHILQNHYVERLGRGLVVNMPWWINAFFSGISPFMDPITRDKIRFNPRLLDLVPAAHLDSEFGGDYNFEYDYSVYWKTITEFCHIAPDGKRVPPPGKEEESKGKHGWIPPAGNGIKAAMEGYVPKEGAVKSGEIVKAGEEGKETKNGPAAGAAPTTTTLSATTSPAPPEEEMEALAIQTAPGKPLDGPVFAHPPSEGEVNEAKKSLDISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4S4</accession>
    <name>A0ABR3C4S4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616891.1">
        <property type="nucleotide sequence ID" value="XM_066754990.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987277"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="383" mass="41782" checksum="FC41071DFD411F97" modified="2025-10-08" version="1">MPGVKFPTLAEPVTLGALQLDTRVIMASLTRNRSIPTTIPNEDNVKYYVQRAGSGRSGLILSEGTLIAHQGTEWENAPGIWDEEHAKGWKKVTDAVHERGGLIVAQLWHTGRVCRPDMIEQKRSGDPVWAPSDVGARGGKFRTLPGQPGYISNPTPIPDPTYILDQYTKAAEMAKLAGFDGVELHSANGYLIEQFLSDISNTRTDKWGGSVENRIRFGLEAAKRLIDVWGADRVGIKISPCGGYNDTYNTSGDSRLETFKTYISRLDSLGLAYIQLMVAILGDDRHGGKPQGFPHDVIGTYGPLIKKSKLVVNGNYTPESGEEVVKSGKAAAVVYGRSYVANPDFVKRIQQGLPLAELNMKGLYMPAVEGQNGSGYNDYPDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4S5</accession>
    <name>A0ABR3C4S5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FMP27 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616895.1">
        <property type="nucleotide sequence ID" value="XM_066754994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987281"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="78228" checksum="757DCDA208882B9E" modified="2025-10-08" version="1">MQGLQGFYPTAEALKRERTQLGMPRGLDFIPLEIFLDVKSEATDYDRVLQKSDIMISIDKFNNIRMPRGLDWPDTLDEYGEPIKHLRVHQDYTAILAPMLTVTANSRNFEALYVIVTDLLMYEDPGHKDRSEAIDDFTRTFDTADRDVGKFVTDINALQTHMRGLLELQHGYETNFERLNDTGKEELFKIRSELQVGYENMYTINALIRATSAKDDARAAMKTSTKMDVRIGGVAWHMLRESRLETMAKVDIDGALFSMLTSKNGMMDNAMVIGDLKALNGKWNTLYPEIIVRDDPSKKKIKKPFAAVYWSTRPSIGGIPIFPYVNIEFVNIRFKLEERVGLDVMDYLFTDRTRRRQISGTAVKPPGGNGASSTTPTSSIFRGAGMASADDLGGKRGETPATENGSLPHSRSQVSLVSLSQSDLDPVSIKRIEDTKEMRLRASTNKMFGTFRFQGMGFNLSYKSDDTRKHGTFSMPDCVDFRFKTPEMVYVSKVWSMEDLFEHIKRDVKSSAWSQSGDIISQIFKKTSLFRSKERLKQAASVTALAEKAQKGKGSHQHPPISPSNLRYAFENSNDSLEPDEDLIRTISRVISHEVVPPEEKLRSKSITRGYSANFDSIRSETSGGSSQRKAHLLSAHDHSPKSAKKPAEEVSESEEKGGGKIKGLLGKLKHKHLVGKDKEPRSSEDSSGSSLRKSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4U3</accession>
    <name>A0ABR3C4U3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616791.1">
        <property type="nucleotide sequence ID" value="XM_066754890.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987176"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="239"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="402" mass="44922" checksum="DF3F78BF16CCF880" modified="2025-10-08" version="1">MSHSFLQLVPSSEFKVLVKQQSATPDRSAIVMQPSQVSARPPRRRLPFESPSNRLATQAHLLRSPTPCPDIYSSDLLSPQPIHTRSLSPSIDSISTITPSTYASKSLPSDETVHSMIGLHASRVLASSTENGCTNAEAIPNHPELRQIQPQECSKPVIQDSIRTDRSRLFSTKPEAPRPLPRARKEVFDVAWSGDGRCLEPSSPITSTAPMAGKTWRSSLPSEDVYHRVANEMGTDEVKRQEIMWEMCETERGFVDSMKMVVKLFASPVKTPHGKWIDGLPDQICSLFDSLQLIINVHSSLINSRQSLNDNYVIDTFTFICVFKAWVNQLKSHESYLLGFETAIHLIEKNIKDPLSVFGEFVRMQMKAKALGSMSLPSMLLKPLAEADEVSLALKRFIERNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4W9</accession>
    <name>A0ABR3C4W9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616914.1">
        <property type="nucleotide sequence ID" value="XM_066755013.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987300"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="27650" checksum="AAAF06A4413441DD" modified="2025-10-08" version="1">MADSLTRRPPVNAFNDDMWTQLAHIIHHTSADPDIRAVVLSSASDAAFTAGLDLKSQAILTPTADPARKALALHSHLLSFQSAVSSLSACRQPVICALHGFALGLAIDIAAACDIRLCASDTKFAISEVNVGLAADIGTLQRLPKVTGNDSKVRELALTGRDFGAREAEEIGFVSEVVDGGRAQVVAAAIEKAKVIASKSPIAVISTKHILNHARDHTVEQGLQYVAAWNMSMLQSSDTAKAMSATLDKKPATFPGFSDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5A9</accession>
    <name>A0ABR3C5A9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase I-specific transcription initiation factor RRN3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617085.1">
        <property type="nucleotide sequence ID" value="XM_066755184.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987475"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="776"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="692"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="859" mass="94160" checksum="03755F18B8201454" modified="2025-10-08" version="1">MTKAVRLPQPSNSVAKPRQKSSKFTGAMITNDPSISGSSRASSMAGKKRPRESDGDGKTRSRRTKSTGDAKDSRSSSSSAKDREAFQRSLIAVFVPKALQESKEGNMTHYNDLLAHFLPTPTMPIVTLSPLLPLLRAVSAHVSLLSPEIHGSLVSAIISLPWATGDEKFVRTFIGWAAVLVTAQPGWMKEVVGMGVKGLTWQPCFGAPSTVSRRVFHARHHLLLSHLISLVPTLPNVLQPLMIRHFPNKREPEVSQTTWIRNCCELVGYCPELGGRMWGEIVDRMLRIDVEINNSLDQDDDESSDDEYELQMGTSQSIVTMLDPLDLLISQEIPRSRSVSHSPEIGVDDEDSEGDPDPDDLSSVDGAESDAEDVAVNELKEAEERAKKNANTKAMREKLDGMLFHFFQHLEEYLAGRKWHPSAVEMASQRMETDVRSGASTPTVETPSIASSSLSRRQPPSPAQSLSYFQTLLNLFSRQILPTASTQHIPFLLFLTSSFSPAHTDLFLGLLVSQALYATTSTVPSINSQPVSLNQRIAATVYIGSVVCRARFVSDDQARTVLTYLLAYMDGKLHQSRVNKRHSTDELPLFYAVCQAAMLIFCFRWRAFLAGADKEGDGILGDMEMDGDSVDDEGKSEGKWMADLDVLQNAITSDLNPLLGCNPTVVSTFAKVAHHTNFAYCFSIIEANQQSSHPRSSSSHALSKSAVPASRSSSGAGSSRQDPTFGSQTLPRQARQLNVDAGLDSYFPFDPYDLPRSKRFIETLYRTWDEVAIDGGLDSDSDSDSESESESQAGDKSDGESSFEDHLAPRGVPLPKLKVGSYGDRRRSLWDSKQDAGLSNSLEGMSISPGRIGMGVFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5D3</accession>
    <name>A0ABR3C5D3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616956.1">
        <property type="nucleotide sequence ID" value="XM_066755055.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987344"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="118" mass="13844" checksum="5DBD58048FA88D39" modified="2025-10-08" version="1">MMMSLNFECLPAWAYDRTCQLGIKALQMRDRCLEEFRRLRTETARLIRGTIDRQERIDKNLDLWIFALKLTEQSSDEGESENEGEEIGQNTGNGLQSTKYTPTRNNCLRYLHLLAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6C3</accession>
    <name>A0ABR3C6C3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Insulysin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_100119</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616598.1">
        <property type="nucleotide sequence ID" value="XM_066754697.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986977"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="132"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="296"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="11">
        <location>
            <begin position="488"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="12">
        <location>
            <begin position="881"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0255321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1162" mass="131566" checksum="DED6B4AD2035CFEB" modified="2025-10-08" version="1">MLRSIASSTGASTHLTRTHHSLHRLVTPRSRSLTLTPARRISATSLIRPTAKAQSFRPHHLSSPARSLFKRSFASPVSRQIPPIKLPIEPIMESPYPPCPSIPKADGPVDLILPPTEDRKHKYFTLSNGLEVVVVSDPKADKAAASMDVGVGHLSDPDDLPGCAHFCEHLLFMGTKTHPSENAYQQYLSSHNGHSNAWTAMTSTNYYFDVSPDALEGALDRFSGFFSEPLFNEDCTEREIKAVDSEHKKNLQNDVWRFYQLEKHLSKPGHPYGKFGTGNYESLWSIPKEAGRDPRRQLIEWWEKEYCARRMKLAVAGKEDVDTLEKWVKEKFENVPVRTEGKPEVGRDGVRVVFDESPYGKEQLGYFTFTKPVRDLRALELMFPFPDMDHLYKTRPTHFISHFLGHEGRGSILSHLKKKGWVNSLSAGNYHDAAGFSLFKVSVDLTPDGLEHYQDVALTIFKYISLLRSQPPSLDAFNEIKAIADISFRFAERGRTSSYCTNLSSWLQSPVPREKIVSSKWLVEEYNQQELEWALQLLDPRRANIGVTSKALPKNVNGEYESKEPIYGTEYKRVKFDEEFLKEAMSGAPITDLQLPGPNLFIPEKLDVQKFDVQEPAKRPAILRDTSLSRLWYKRDDRFWLPKANLDVMLHSPILNVTPRNAVLSRLFCDLFSDSITEDVYDADLAELSFNLWNTSHWIQISAGGFSDKLAVLTEKMLEKFVNYRVDEARFQEVAEATRLHWKNFAMSDPWKIGRFYNSYATQETAWTQEEKLKELEYITAADVQAFGRELLTRLHIETLIHGNTSPEGAKEIQDMLERVLKPRELTPTELKAPRSLVLPSSSEYVWQIPVPNKSEVNGSVIYEIHVGDPSDITLRNHLSLFSQIAAEPCFDILRTKQQLGYIVSGHASQSTGTMGYTVLVQSERDPVYVETRIEAFLDGLKEIIEEMSEEEFEKHKQSLIAKKEEKPKNLGEETKRFWGRIQDRYFEFSRRENDVAELRKTTKQDILNVLMTYIHTSSSTRAKLSVHLKSQYKGIKFDLASAAPLVKSFTEAGIAVDPIAIQKLLSNNPTLEQVKEFANSTIDAASNVADDVKAQLKDVVAELKGQEAGPGAEAGAGPGPEDVKVRPGNVWIEDIQEFKARLVLSKAAVPVEPLKTLAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BID1</accession>
    <name>A0ABR3BID1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_106705</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610952.1">
        <property type="nucleotide sequence ID" value="XM_066761127.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993560"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="10"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="495"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0240453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="529" mass="57334" checksum="3303F067933B461B" modified="2025-10-08" version="1">MPLPTLAVVLGAFASFSGFLFGYDTGYISGCKEMETFIRTFGALQPDGTYVLSSSRDSLITSILSVGTCLGALCGSMVGDRIGRRFGIVFYICLFFIGVALQTGCKNLAGFAIGRVFAGLGVGGTSCLVPIYQAECSPKAIRGLVVAAYQFFVTVGLLVAACVVYATKDRPDNSAYEIPIGIQFVWGALIIGGMCILPESPRWLLLKDKQEQAKRSLSRLLGQAEDSQAVTTEFAEISANLEHERSIGKGTWMDCLKYGESKTRLRIFTGMALQALQQLTGVNFIFYYGTSFFSNSGISNPFLTTIATNVVNVGMSVPGMLAADRIGRRPLMMYGAAGMAVSQLIVAAVGVGVDTTNQAGQKALVAFVCIYIAHFASTWGILAWVITSEIYPYELRGKGMSLSTATQWLFNFGIGYATPYLVDVAPGSAGLKTNVFWIWGGCCCIAFVFAYFFIPETKGLSLEQCDLLYRKSTVLKSAAYRRQILEHDMHDDEIAHYGPNKGPRTDHVEDSKAVEDAKGEQSHLDVWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BID2</accession>
    <name>A0ABR3BID2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106709</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610956.1">
        <property type="nucleotide sequence ID" value="XM_066761131.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993564"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF51">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="59"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0240457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="539" mass="58209" checksum="153FF953A7FD9DCD" modified="2025-10-08" version="1">MVSDIIEVPMAEEVAKAHDSYSEKALDESGVVVHELGSDSFPTVVPAVGKWAAIKADRRAFAWSLYILFYGFDGLLAGSIIGIPAFQKHFGYYDEASGSYIISALWQSLWTAITALAMLVGSLACGQIGDRFGLRITLITAIIFTIAGVLFEQLSRTPGHFLGAKTVAGFGYGLQTSVAMMTLSSFAPVSLRGPMGAGLNTFILFGGWLASGTITGTGTVYPDSTKAYQIPFALQYVFIGIIAAGVLFVPETASFYLKQNKEEEAKHALIKLHGPSRMDLVEQDLERAKVSRELDNRFSHAGLTVGPLEPFRKPHLKRTLICCAALGFGQLAGASFVTTYLTYFFQVAGAPDNTSLALGQMSFTLMVIGNLVSWYAIDKLGRRVCLVGGLAIMTTLLIIIGITWAVRTSASLWIMVALMSLWAFFYQGSIGACGYSIMSETPSARMRPATVALASATNQVTSWVMGFATPYMVNPDEANMGGYVGFVFAGLCAIACIWAFFCVPETAGRTSAEIDKMWADGIPVRKWKGYTTRVEQEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIS3</accession>
    <name>A0ABR3BIS3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nucleoporin SEH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_106748</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610708.1">
        <property type="nucleotide sequence ID" value="XM_066761168.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993601"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="142"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0240200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="41029" checksum="F10ED9282E4BFDDA" modified="2025-10-08" version="1">MLQTDLLAPAHADLVTHLTYDYYGERLATCSADQRIKIFRKDENEPSTTATAAAAAAAASFSSSRSPPTFPSATSASTSRAWLERGILTGPTGAIRSVQFGPPDPAFGLRVASIATDGYLRIHTSLDPSLNDWSEIVKVHVPSLPGPSSSGPGGASGDDGTGGTPSSSTGGTGLAGTLALASNTGDGGSSASHHPNTSELATGGWGLSWCKERWWGPLIAVFAGTSPSIKLISLSPTPSCVLLLTPSSPTTTSTTTAAATDTTTTTGSGSGPTQYAPLTCLAWAPNCGRNYHLLATGARDGTIRIWRVEPPGERGRVDYDTEGEMVKEWRGQCTGEFGKGGARVGTVDWNAAGTMLSTTDDEGIVRIYKPTYARSWSLLGSLAAEEPPLEDGLNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIY6</accession>
    <name>A0ABR3BIY6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106451</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611152.1">
        <property type="nucleotide sequence ID" value="XM_066760880.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993306"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="626"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="949"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="639"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="846"/>
            <end position="856"/>
        </location>
    </feature>
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        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
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        <location>
            <begin position="888"/>
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    </feature>
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            <begin position="953"/>
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        <location>
            <begin position="964"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1107" mass="122938" checksum="F1B4538939B982A2" modified="2025-10-08" version="1">MAVPPPSPAPDLPCDWPVPSPTPSPSPALTPASHSPPHDGRRSWKPHGGDARAAAGKDKAGWGDLPVEILHRILSYAQDAVPLDFTLQTYYGHNQRTREIALALVRRIWFCRMRMVCTGWRNAVDSHPFWPEFTLLLDPSRHHASTISDIPPPASFPTLFHRARSSTLSSCLACRLNRPSRLGHYPAVRKRLTFTSKFALAPTCEKHANSFCSGCMRESEPQADRAPSPVLRHLTDIGARVESGETRSPSEPAVPPLMLSQCNHGDVDENGVERFPRSLVCPDCRKAAIWNEIRLILHECARGGRMRGERSLWLYNEKVKDYINFNVGTAFEMGYAAVEEQWLIDHTRWVELSETALQLQNHEKALKLQFLRTAVEETAAQKRMRLAREAELRGEDQVSRETEEEAMEMESLYRSWWKELEDDDLASDDDEEDELLNDKFRGKLKAGCINDFISDRIRYAFWVSPSDEVSKIVTDDRDRRTDRSSIIHTMFLDIAMNSAHPFSKYIEFSFEPAQACAEAAGLISLVPNDPSSSPVSDGRFDPFLPPDRLLRALDQTFAEMLSARTSTAMENIVRNVREYCDDDDDKAEEVCENMRVQDILGRLAAWQMWVPRSLAEQMKLAEMQKEMEAEGQVGMQGEHEDDEESEGDLEGTIEQVPRSRSGSPRVELVERGEEEVHFTPVEVPPSDDYHVFSHPSSPPSFSYSSSPHLAHTLGKRKSDVILPEPTDKRARPSTSPDEREGGRRQRGLEQSPQTPPKQILSQEDNTSDGLTMDTTTATDTVASSVKGTGAWAGGLKRKEPPSPAVSHIDKGRKEVTPPPGPKFDWADGHYGDKRTRVTNDLVQEESSAPVSSLSGSPTPAKTREGGALEDNDADVETEEMSQRGTSATETVGTVPVTPEEGMSLGGETVIDPKLVHMDSERSDVDDPQRVQAQSVQTIDNPPLIELVALVTPSPSPSPSPSPSAFPARSRSPSTMSATDSYSSGSASIPLDGDGAFTPLTSATARLARYIKRAHTSTPFIPLPICRFLPHPDHPVHPNQGGQGVQFPVNLGQGANRVLLNTWYEARGELRECKCRICERARRKAWESLEAMKQLVASGEVTWETLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ08</accession>
    <name>A0ABR3BJ08_9TREE</name>
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        <recommendedName>
            <fullName evidence="5">Mutanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066760797.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glycosidases"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="66742" checksum="AA5DD09BD3360ACC" modified="2025-10-08" version="1">MLSLNSLITLLLSAHIVTAHNLDLRHSNRHARRALKRQQQSVAGHWSTYESSTWIPDNPSATAQIAYETVYVTETVWEDGPSPTTPQILTESSTQSTSGSGSTSTGEVGVVNLAATDHITSSSAPSTSNSVVTLAPSSDEVAIGTSSNIAAFSTATAIAVSLDSSDLKTEIDGLGFTTSIGETISIGFGGGSSPTTTSSAPATTLTASGDKKVFAHFMVGIVSTYSISDWESDMQLAKSKGIDGFALNIGVDWYSQEQLDLAYQAGASVGFDLFISFDFNWYTLANVSGVAEMLKRYKDQSAQFRVDNKPFVSTFIGDGFDWNSVATVVGEELYAVPFWQPSADNANNAGLSGLFSWDAWPGQLDNVPVNTTMSDTRDIEYLGYTEAVGKTYMAPVSSWFSTHFGAEVSYSKNWVFKSETLWKDRWDEILQLGSRLDFIEIVTWNDYGESHYIGPYNTPHTDDSSSAWAAGLDHKAMLDFAVPYIKAFKAGETAPVIEEEMLVYWYRPHLKSASCDSTDNCGSKPTGWDFLGDTVFVATMTKSGGTVKVTSGNNQAVVQQLEAGVQMIEVPMGVGEQTFEFVTFQGGYGKTTSNVTISADCWNGIYNFNYHSGSITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJE3</accession>
    <name>A0ABR3BJE3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066760539.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992947"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047089960" evidence="2">
        <location>
            <begin position="19"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0241918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="645" mass="72836" checksum="F7661B5E5880A13E" modified="2025-10-08" version="1">MLIDIWPTLSLGALAAQAARISILPDAAQVMLSDTNNINTVELDAASADEWDCDIRSWVRAPDLAPGQVHPAEARLAMNGSSCGEIVRWDVGLRFKERAIIKLRSKTVDDFPTKPKPALYHFNRPMGHDYNDIFSVDGAWTYPNQGYQVQMAEYAEAMRNESLWNVQGVERVVFDTTQELPLDMIDTRDPVDEIRSFYVHVPNTNFPPIISDIRRSMGAGQDGQSINTETQMEYYHLLHLANGTVLDSPAGRSGFLPRPYPIAPSASRAPEEGVATPLEAQIKLDSPRMAANETDDDDSRWMRPGRAVPLCDKGNLAEFHLEVNSDAKTGVQGRNVTLDFSLTRSGNGTEYPAFLDLRYVVERNLTWAYNFVHTEEEYADLVMPYRTSRRMSRPPSLSVGSMLKAPSLKELERRRDREAGHQMGIYYSSGGRYPLINGDVRYDFEEKDDLGKDQYTFQLEIPIAEDAWPTFTSTFESFLSTFRVTLHTTFLCENSTSAFVVEEVSADEPQYTERDAEWSEFRLPPKTDESKSRKSQRQGRSLNHDGSIPFAVRLMSEKAVVDMPVHYLEPQALAPVLSLDSKLVSDYPRVGSNLHEEDPTQLKKSRYADGVRGLSRSRMMRNNGGLWMHAARLWQAAENKDQNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJQ5</accession>
    <name>A0ABR3BJQ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="8" type="ORF">I308_106197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611405.1">
        <property type="nucleotide sequence ID" value="XM_066760644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993052"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="193"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0242023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="429" mass="48782" checksum="BBEF1C93A0D5C176" modified="2025-10-08" version="1">MADYDLTQPRYDLAKGTNMVNYVEQFHAQIENAEPTDFARLREEATTKYQELQEKAQPVTKVIEDPDAVAKLRSGGDKDRNLDLLRSEYQIDIDQINALYHFGQYQYSLGDYGSAGNLLYHFLILSPSYELNLSAQWGKLASNILNGEWDAALVQVRDLRETIDNPHGTSLAKPLAQLQARTWLLHWSLFVFFNLGENQGCQGLLDMFLSPAYLNTIQTSCPHLLRYLVAAAIISRRAPKPANVRSRDHVKELTRIVETEEYQYTDPITSFLKDVFADFDLTQAQQRLSVAESVVRSDFFLSGFADEFVENARWLISEVICRLHRRIDIGQLSKTLNLSNEEGEKWIVNLIRDSRMGVEAKIDLKENMLHITRPHATPTATLIETTRGLAFRSQAIQFAMQSSVGEPRERGERGNKGGRGRPRTQEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJS3</accession>
    <name>A0ABR3BJS3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106228</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611422.1">
        <property type="nucleotide sequence ID" value="XM_066760661.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993083"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="53"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0242040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="400" mass="44903" checksum="81A46D298FBAC96B" modified="2025-10-08" version="1">MPRPSLTSATDYTPAGPNDKFSRTNLFDPVPEPKTELGRYRLLSPSAAIRVSPLCLGAMSLGDQWTPFMGGALNFEESCKYLDTFYEAGGNFIDTANNYQDEQSEMIVGEWMEKRGIRDEIVLATKYTTFSLDRKEGKFQGIGANFVGNHKKSLRISVEDSLKKLRTNYIDLLYVHWWDYSTSIPELMQSLNDLVKSGKVLYLGISDTPAWIVSQANEYARHHGLAQFVVYQGLWNLGVRDLERDVIPMARANGMSIAPWGALGQGKFKSPAELKNKEKWRYGTPPTEKDIKISEALSDVVKELGIDVKPASIAMAWARQTVTDCFPIVGGTNIEHLKSNIEALKITLTDKQMEKLNKAYEFDFGFPSNRFGRDPHYLPEGKPNNGLLTTAGHLKYTQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJY0</accession>
    <name>A0ABR3BJY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611296.1">
        <property type="nucleotide sequence ID" value="XM_066760535.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992943"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="6">
        <location>
            <begin position="769"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="802"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="965"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="873"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="902"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0241914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1005" mass="109015" checksum="16D32C78AE5D898E" modified="2025-10-08" version="1">MPVPAVTTSAAGSLTLLEDPDKDIRVYALNHLLSIVGQFWAEMSDKLPYLELLADPLSKELAPDDRPFAALLISKIYFYMGFQDEAVEFALKAGVAFEKEPEGEYRETIIAGCLDQAIDKTQRGEDIPADLQSIVDSVLRSSSGENAKLAMGLALSLRRLDLIEMIYLSSRGSSQASSSKSERVVHDESLLRYVLAEVVSGTSGNEAWPEDFRANLFSLLRRLFHLNPNPDWNSITTVWAQSSDVESTVESLVKLLEVEDNLTVYQIAFDLTEVASQAFIDEVREKLGETKWAAPVDGSEDDVRVVLNNILRGDTSAELFLNFLNKNNKTDMSILKTTKETLEDRYSIYHSAITFTNAFAHCGTTSDKFLRENLDWLGRASNWAKFSTTAALGLIHRGSWVNGNRVVKPYLPGGAAPNKYSEGGALFALGLIYAGRVEFAEEELKKGLAEGNDPIVQHGAALGMGVSALASADDEIYDEIRPILFQDDAVAGEAAGYAMGLVMLGTASERAVEEMLSYARETQHEKIIRGLAMGIAFLMYGQREAANPVIQRLTEDKDAILRYGGMFTIALAFAGTGNNKAVKKLLHVAVSDVNDDVRRAAVTALGFVLFRNHTTVPRVVQLLAESYNPHVRYGATLALGISCAGTGLESAIELLEPMTKDPVDYVRQGAYISLAMILIQQSEAACPKSVAIRELFAKVVADKHEDPMARFGASLAQGIIDAGGRNLTLALSTRAGTLNQNAVVGMALFVQFWYWFPLAHGLGLAFTPTAVIAIDGKMKVPQLELECHARPSLYAYPATEKKVEEKKKDKQKAAVLSTTARAKARERVKKAEAGEAMDTDDKIEESGKGKDTAPTPKKPKPSEPSSFKIPNMSRVTPSQLAHVTFPTSGRYTPVRPLDHSPLSGSSVNGKPSTLASGASASGSIVVLRDEKPEEPAEYIELSKELWPGWLPANPEAAAAILAQATAEGSGAAPGSGVAGQAQQQQQEPEEEAEAPAAFEYPFEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK07</accession>
    <name>A0ABR3BK07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallothionein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611509.1">
        <property type="nucleotide sequence ID" value="XM_066760205.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992611"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0242127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="11464" checksum="F3C3CC89363D3E67" modified="2025-10-08" version="1">MAVFSYIALNPACRSGNCSCSNGNSSDCSHGSSCTSCSRTLTNSNSGGCTHGSSCGSCATNGRTLVNECNTTGANGSCSSCGSSSHLPALFEMDRGVFFFLSERLEFDRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK51</accession>
    <name>A0ABR3BK51_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA-binding protein creA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_106455</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611155.1">
        <property type="nucleotide sequence ID" value="XM_066760883.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993310"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="389"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="492"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="612"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0240656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="731" mass="77759" checksum="907A9BF65915BB78" modified="2025-10-08" version="1">MSSTDNNSPNSGNTGENTLNNLPAPIPDPVTGRLDPNDPTVKALTEAALNMDKSKIPRPYKCPLCDRAFYRLEHQTRHIRTHTGEKPHACTHPGCDKRFSRSDELTRHARIHLPTANENGSKGKHKYHDDENDHEDHRSHSLPHLGPSYNMDVDRSSYPYNLHSLQMGGPSGGISDISALAAAASDQLIEIERHEAFRRAEWELRHRQIAGARKSNGGSPVGTPGGPYGFSNERERMTLSGVATSSGGQLVYPVSAPQPATGTLPAVPAGTLADPTYLIPPTCCHEECHKSYRKRLKLAKQTAACPNCLTLAHPGNSGGFGSLGGAGYGSGGGDSHHSSNSNTPKDRSTHNSSEDLTKFANGGQSHYSLQQANFAQELATLQFQHLQALQRARSGTSGHSTHSAPHSSSHSHSASPAVPAPHNHLRPYTIDLHSHRGGLNSSHVSAAPSPASSDDSDEELMNEIIPHGPFDFTPATSPVLSGMRQMSLWHGKAVTAPPSRATSPVHSVSRNPSRPGSPVEGHNANSGKHGHTSHSARDAKNRSHPYTHHYSTTTPNSPHFPAAIKSRMSPPKLHRTLGGANNSNKTVQDILNAPSIPPPSDRLLPPPNSSSGFTSVPNVSYSISSQPTSAHQSPNTSRASSPTHFSSNNASGHNSHSHIIHGVRAAFGMTPISSMARDGKASGQHVGASYSPPHKLAPLGMGGEGVRLPSLSRGSSPVHFDQIGMELGGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKF6</accession>
    <name>A0ABR3BKF6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611461.1">
        <property type="nucleotide sequence ID" value="XM_066760157.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992562"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0242079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="32387" checksum="AC1448AD4E40A1F0" modified="2025-10-08" version="1">MTVESPNVAQNFESGEEVVDLAVAGQPQREDATLLVSLKTPQLFSLAKQGVIVTGGARGLGLALAISLLEASAGHVYCVDILPSPVADEWSLAQRTAKEFGSKIEYRRLDITDEEAVTSTFADIYSTCSYPVKGFFAAAGIQQMIPALDYPAKDFRRIMEVNVTGTFLTVQAAAREMKARNIAGSIVITASMSGSIANKGLTCTAYNTSKSALLQLCRSVAAEWGQYGIRVNTLSPGYIRTAMTDGLLAELPDLEQEWLRGSMLNRLSTPDEYRGPLLFLLSNASSFVTGADLLVDGGHTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKI7</accession>
    <name>A0ABR3BKI7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611687.1">
        <property type="nucleotide sequence ID" value="XM_066760383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992789"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="337" mass="38136" checksum="26CAA661300CC107" modified="2025-10-08" version="1">MPQPPFELQKYLSKALPQLREQYPPGTGGTGPRAHWDGSLKGVEVIEGFGDQVVNFWKTILDKPVQPHPSFKYPKIAQVHSKLPNPLKTPRDLQTCLSLLPLAACSAALTALDADPADLKTTGPHALDKAGYESDGGEEPEVAHQREMKTKGWKFRFNKSPMGSGEFLLMREGSDEVKLVVRTINSSAFTLDDWKEYVVSGPYHYETRSKASWYWSRAWGATKRLGCHYYVLTDWQRWTFGYFNEDRTHGWTSPVLHFNEQNPSIGHSLFFWARSAIGKENGFKPQEKDVSGLPKIFPINPSRRISSSGRNTPRDDLRRPKKANESDIEESDVEGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKP9</accession>
    <name>A0ABR3BKP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611738.1">
        <property type="nucleotide sequence ID" value="XM_066760434.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992840"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="612"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="691"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="587"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1283"/>
            <end position="1305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0242356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1352" mass="148377" checksum="F09A37E4758BBF82" modified="2025-10-08" version="1">MINAPPCSSRHVHSPPPQRPRPFATRAWRRITNPLAHPVTLSALSALLPLAYATPVPPHLHHRARLRLRSRSPNSLHARPLSHPLIHLFSSLGESLARRNDVAGPILDVAYYSTSAEDYKLPAGYVILRTHFNGGFIVLAYIIAFIGSLCTVELLIRRTTNSGWRNQALLAAAGFCFGAVSTFAMHFVFNNALGLKHPLHPEYPASYLSYDAGFTILSLVVSCLAMTIAFFIMGTKLGDWKYGSRSKRRHKKRKDRDSRSQRERDEYREWKSSHKKRMQAGSKGPCSLPTRVGSHSTWSALDPETETSETSFRGKLFSLWYKPGWKDSTRSNEPENSEDKDLQELEFRLGKAAVEEELEKKTRDTLNGRMSRRASLPTAQSLSDFSSPSAEFRPVESSLPETTSIFTPNFSFPAQVPSLFPQTNTADTSQSITPNLESYSSDANPHPFSARHEWRRASLPTNILDTQPPKRPSYSGPSHSGLSRIQSLPEGDIDSPPSPTTFRRLHTSQKSDSSDEAKLSLSPEAHMHELQQEKSASSENARESESDRRAKLNEKKNFWGKVGAFLGFDIVTVGEVIKIFFTGITAGFGVVGMHYIGQASIIGIPYVAYKPAYVVGSVIIACGAVVIALYIMFIMLRPKLKHTWWSKILVALILAVAVCAMHFCGIMGTIYGWPAARSISKHSQLSGTNAAITGIVSALAFAACIACTVFFFLHSLHLRREQARRRRVVVASIMFDEKDRILVNSTDGMLPMCDIASLTGGVHGGASGRGSFIHSLSSESTVLGMDLSTGHEAFVSALKLSWMWRNPTTSQQNSLLSSQSHSRSHSHSQSHLHLHATQSQADSALASSLLDIRRGSMVTNNTSTTLTGSRSVPLSISKFLEKFSTSSGHLAMRLTGQINGITRLGVLYDQILTTGWVKLQNSSDTVSKGQLIFLVRRVSSAAEQFDLASRHYMFADPSAVASALHRTLSVPFDHIMPLLDDIRVFCDSTLHCTLHPGKLYAGVAVVQATPFDGLRILLEKDKRGQLPMREICAFGTSSTESGALCGTVEEIGEALSMLQGFNMLSIISRNVSSRTETDPLFSGRVSTLFSALERAIVPMLDEMLTAEDMEHILPRLTLHPVLVPLTPGGRPPSFSAKRSPYTPPYLIVFYANYDVAVNTFTDKWLPFNLFRAQNACVMSQKVQVGMRMERIWGENEQDGSATSTVTRRPSKVQFEFPSSGAQLAPGPTFDTNIFNGYSFPASDDNQNNQTNPPRYSSSSSSAAQISPLVTVNRKSSLAKRRFSSSGNESPAPSTDSGAGSAQGVNGSTGLGIGQSSVGVGRDALIKPMWPGVGVWDQDWLLHLLRAKLKAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL10</accession>
    <name>A0ABR3BL10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610935.1">
        <property type="nucleotide sequence ID" value="XM_066761110.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993543"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="549" mass="61775" checksum="DBFD659BFA9E7AF6" modified="2025-10-08" version="1">MTEHRPSSPSTATSQRNQSAKGLNRRGTYGTENHLVFHEDFQEEWKPLRIRELIRPLTVRQWIEGGKIHREPVSRETPRFELFFDLLFVAIIHQLADAAIEEPGGRSVARFILTFWPSWSVWEEARKFANQSGTDDLLHRLWILIGMMTLIGYTANASAIELEPTGEEEIVDHSAVRAAVAFWLVIKLTRVIVLLYYAWKSPSFRGAHIWKAIAVLIPMFFLLPLIWVTSRTVQIVLATLLIVIDVCRIDLLELAIRGRIYEFQQRRAEGKKGLGMKGWHRMPDLPQGYKIPVMNIEHAVERLGAFVVIVLGEMVMNLVYTATKGEIGVSHQFGKAALGLMVAWAINYLYMLPSEPNADYEHALRHSWFSGVCFTFFHWPLCAALVLASAASGKMVANDEVESGVHWYWGSGVGFAIIFMAILDLTHHNLAPGQARIPRVIRALLALCAGLSLILFSLGTEHMSSTAVLAITVGITWFLLAFDIVGMLPKPGTVQKEELQRREREEEQGKGVVVQDMDGRGRLESVGGVGEVREERMEEGRLEEGGSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL86</accession>
    <name>A0ABR3BL86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein OS-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105529</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OS-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611929.1">
        <property type="nucleotide sequence ID" value="XM_066759983.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992384"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046149040" description="Protein OS-9 homolog" evidence="9">
        <location>
            <begin position="22"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="146"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0243562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="533" mass="59979" checksum="FC0B853CC1237EA3" modified="2025-10-08" version="1">MHSSVLLYLHLLPLLPALAIGSGPHQLRDLYAYPKYQVQFLNDLPISASDAKRIKEVGVGSEIEWIDMRLGDRSLEDGTKRERLELMSMSFAAKSHEKGRSPYEYLCLMPSNNSTASQMARIDQLEEVEDELDPDQGWKALSHLDGKCLYSKQGWFTYAYCHDSYIRQFRAAAHPHPHPTQGYVPQEDPKYEGYTLGRPHPVPKSKGSRAKVKDGKPGSPAKAEDRSTAVETTGSASNTRSSPAVSFGLGASSRYLVQRWSDGTRCDKTGRPREIEVQVHCSMTSGDMIYMIKEVAICQYVMIIHSPHLCGLPGFKTHDAEVEPANVMCRQVVDDEEWAKWETEVTDGTTGTDEPRPQEIEEGKETRRSGQLPFSDWPGKEKLQSRFGHAAARERPAGDAVSHEQSRIGETEDKASESIPIDIIFGLDMDEDMKGMLKRAVRLLAKQARGEKRDNDGEEETEGDEVVLISWDEDENGRPVLLEADILLKDEDEEVQLEMGAGEKDMLEKVLRNYMLKANDEEEEPRKRVVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLS0</accession>
    <name>A0ABR3BLS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611941.1">
        <property type="nucleotide sequence ID" value="XM_066759995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992396"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="236" mass="25633" checksum="81C084522593C864" modified="2025-10-08" version="1">MGPPVRMLFKITVLGDGGVGKTAITVQFTMSSFVETYDPTIEDCYRKQWVVDDQPCLLEVLDTAGQEEYTALRDQWIREGEGFLIVYSITSRPTFERVEHVVERVLRVKDESGLPLPSPSSPSNPYGLSTTGGGGSGSGGGGGMWAARVPIVIVGNKKDMFHSREVSTDEGASLAKRLGCEFFEVSAKTNSNVEAAFKCLVKKIKLGRQGGAGEESVMPTERIGGKRKKKHKCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLX9</accession>
    <name>A0ABR3BLX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Type 2A phosphatase activator TIP41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612001.1">
        <property type="nucleotide sequence ID" value="XM_066760055.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992456"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40504" checksum="CBECCA107F7625BB" modified="2025-10-08" version="1">MAHPPAITSDPAKLPHLSMSNPAYSVQTLRNVHSITIGSWSIVSTKKPILNGKEIEAAEKSLNLPLPEMTFGNNSLSLVYNPTTPSPLDLTTASRPITVSLEGRVNLSFKTLDALAGVATGEGWEERVGGGVLVSMAEKWGKNKSWATTESTPVPAAGVFDVPVPSKPVKPHDWTYSTCYAGSIAGPSTFEPSPTHSLPLSLLARQDPVLDQILYYEDVPLYEDELHDNGESILNARIRVMPHSFFILARLFVRVDNVLFRIYDVRIYHAFGSEEVIREVSGMEAGYDTVKQFLEKPSDLSPLTDPNWVYSVMTQLSNLPVHSPAHRRSSSSSSSRPGKPWPGLGKKVEILKLPKVAVDEIGKGLEKVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLY6</accession>
    <name>A0ABR3BLY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610953.1">
        <property type="nucleotide sequence ID" value="XM_066761128.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993561"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="262" mass="29112" checksum="916613FC591CE507" modified="2025-10-08" version="1">MSLTKVAVAGVINLPDSPSNGSIPPVSLTKTHKTTYSMSGLPASNVEIATTVSIEQDRGTGLEEKGILRQVGERTKRIERLLLASGLLSNDALEKAHGRLLGDILRDTSSSAHHRHSDPPICPLAVIAYLDPGFQPILSMFGFRLGRKHGQSPRWEQDSFRDTINCRACHCETLYYALIFSSICMIIRTIYRVIEYAGGSEGPVAENEACFYILDTIPMLFLVGICHLATQMYRGTERHYQSAPYDYDRHEINESLALDDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM73</accession>
    <name>A0ABR3BM73_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase assembly protein COX19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the assembly of mitochondrial cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611920.1">
        <property type="nucleotide sequence ID" value="XM_066759974.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992374"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="8">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0243553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="115" mass="12626" checksum="CDFB2FC6A7227F71" modified="2025-10-08" version="1">MSFGRPGFADVFKPSPPARGSFPLDHDGECKTFMISYLKCMKENANDNGKCRLFSKQYLECRMDKGLMDRDDMANLGLGDVVDPSSPPPASTQTTTALSSNPPHVPQPPPSEHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMP2</accession>
    <name>A0ABR3BMP2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105488</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611889.1">
        <property type="nucleotide sequence ID" value="XM_066759943.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992343"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="217"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="410"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0243522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="504" mass="57063" checksum="E1D13583B455C7CE" modified="2025-10-08" version="1">MPLNYSKWDMLELSDDSDIEEHPNVDKKSMIRWKQRDIHEKREARKHLIFKLKSELSLNSVLRPRIETIISGLSSSGLDHYRAVQRRMKEDPSPEKPATGAPNQPTYDMMLSQLLSDVFREGAWLVEGGKVEGNSVIFNGKKVDDNTGLPDWATAEVPEGKKERLAEKLEQRLKWHVSELNRRDEQVKKEIEKEEGELKKKITSEDIHEGWSSSKIAPPKPSVWDEKPKPKSKKTEKVETIEVLNPKASSSAAPLAPATEDTDDEEDFGPLSPAGRAFAQIPLGEFEKSYEFIKNDSSVLSSSTHDSLLAEAFDAERRGDKSLAMRCVHQSLLVSYCRQLGKDGVGLFFQKMIQKNPKSITMFNEDFQRTYNRIATRTQEILAEEAAAGPSGEREQIQLVATDPNMTIAFNIPDGPPPEDLRLEGEGAEELDVEQVRAWLQRKWEIFEGFPPQFQDALRTENLDKVNKVLGNMTVSEAEKIVELLQEGGMLSFSEKGVRDMTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMS3</accession>
    <name>A0ABR3BMS3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612456.1">
        <property type="nucleotide sequence ID" value="XM_066759809.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992208"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0244089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="760" mass="83675" checksum="9F5E40134C463808" modified="2025-10-08" version="1">MPPVSISQYVCGANRCGKSFSSSSHLRRHERTHLGTRPYACKHCGKTFVRKEVCQRHEGLHSGLSPERPPSILSSPRQSSHAPIAATTKSSTALSNEVPQSTSSHDCSASVEASQPIISSVTSTSQSIRNQTSSENIAPPAFNSLPLVSGAARVSQNVNIPDLMQSPLQSAEALDLRSWLGQPTNLLFDEQVYGWLEQVLTEQNATQSLQRSTGFDPYFPPINTVLIPTDGSNNPGHPTLGDDLKTMLTQIWQGLSFVKGVSMAENPNIAQLFAAGWRIILTRFPIVHIASFDISTTPPSFLSSVIALGAVHSTQGIDRVFARQLLPVIRAMAVSESLDDTKSRLQTIQAFLLSAITGEHLNTHEQHQAQGMVSHAMSLMRRFGYLLMTGSGENDNNSDQDTQWRTWAEQESRRRTLWLCWILDIRSVTLGHHFGSRARSPFRMIIELPCRQDCWSASNSFAWARRLHTAQTIPQALQSTLAKDWSREWFADEQLDFARLVVIHALAALAWDLAHRDLILPPELSSEGPSKIAVSLVCGMQSLSKHPSLVNENLTETVTPLTAEAYDISTAACLDIFTDLTSLEVFCGVSTVGMIQNVKTSDRLEANGKMRSWSRTSKAAQAVLVAADFLKQSIQSLSRWPKSVSHSWTVCFAFLVLWAFHCCHSDGSDWVTRSLQAGNSSLEGVEQRSSSHNLQQRARKAIEYCEKAAAHARSGNPTSPGAENLGELGHIAIEIMQGVHADIVFEHIQTLRRILEGTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN91</accession>
    <name>A0ABR3BN91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612310.1">
        <property type="nucleotide sequence ID" value="XM_066759663.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992062"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="151"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="504" mass="55730" checksum="D052F21511218304" modified="2025-10-08" version="1">MPVQANTSPRYSLQPPCGLPPLFSLPPLATAHDEDGDTLISCFGTLSISSLPPKGESTEVIGAPSARAKLYPGPKLSDRATQGPDAGPLIDRFSCLFQDQYDCMLNPKGIVSLGVAENFLMQKQCMELFSSALQNNITPLDLSYGDSLWGSRRINKALSGFFNEWFNPAEEVLPEQIITGVGCSAVLDQLFFNILDEGEAVLLAAPYYTGFDRDLISRGRVKLVPVHLSPEQAFGPESLELFEQVYNTVTAQGIAVRAVIVCNPQNPLGRTYSRETLLAYAKFCENKDLHLVSDEIYAMSVYDNKDFPEALPFTSMLSLNVQEELGIDFDRSRLHVVYGMSKDFCANGLRVGSLVSQHNPFLLRSMANTSMLMKLSSPADVIWSTLLQDKTALKKFITTNRRLLGEAQAFIRKWFEDRGVPVADHNAGNFVWVNLGAALEFEDVATEKQIFQKLLDGGVYIAPGSAYHYHIPGWYRVTFSVARDNLIIGLGRIEKLLGLRLIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNE3</accession>
    <name>A0ABR3BNE3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612671.1">
        <property type="nucleotide sequence ID" value="XM_066759184.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991576"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0245587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="102" mass="12011" checksum="1F5F1FD4141CBE98" modified="2025-10-08" version="1">MLFGIIPAPDEPAGSVLMYGLRVKTLKYPEGRVVPHYNNKIYRTRSYYPHTALVQQKMSSLRDRVRYIRIASHLMSLLIWNESNRPELFNFLQQTGQQLHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNE7</accession>
    <name>A0ABR3BNE7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TRM5</name>
        <name evidence="12" type="ORF">I308_104727</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="9">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="9"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612677.1">
        <property type="nucleotide sequence ID" value="XM_066759190.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991583"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="11">
        <location>
            <begin position="193"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="365"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="320"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="348"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0245593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="548" mass="61523" checksum="56F9F1C2668B2499" modified="2025-10-08" version="1">MLKSLCLVIRPAIVSRAQIRLPTIARLSLRQFQNQPQSVGFFTMASLGSRALALSPSATIRPPSHTGMTELDRSAFDLDVQILSAVVEPGMIGKLRSHPCLKDLVLDMPKTKPIVECPAELIPAAAQNIKGLKLLRFHLSQENELPEEAKEVLKGAKALVKEVVRLGYDNWNASEILGACLPTTKSEDIPSSFTTTGHIGHMNLRGEWLPFRYLIGQVVLDKNPSLRTIVNKLDTIHAQFRYFDMEVIAGDNDYIATVNESGCSFTFNFSNVYWNSRLHHEHERLISLFPPGCVIADVMAGVGPFAIPAAKKGCYVLGNDLNPESVKWMRENRLKNKVEPTLRVSEIDGFEFIRIAPLEVWTRPFDPAPPPKMSNRQRDREAKEARRKREQAKDAGQPVAETASMPVPSHEASIESQSVHPPKLISHFIMNLPDSAITFLPSYVGCYAPLLSEKTFVDEYGGKEEAKQKVEMPMVHCYCFTKEIETDKAEIDILQRASINLSFNLTPQVEDYNLHHVRSVAPNKDMYCLSFKLPREVAFRHNENKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNI8</accession>
    <name>A0ABR3BNI8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malate dehydrogenase (Oxaloacetate-decarboxylating)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104761</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612711.1">
        <property type="nucleotide sequence ID" value="XM_066759224.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991617"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="5">
        <location>
            <begin position="92"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="4">
        <location>
            <begin position="283"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="550"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0245627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="64963" checksum="6F39192C73AB15C8" modified="2025-10-08" version="1">MPSSTLTRLSKSLPMSSSNSTVRVALRGGAILNNPRFNKGSAFTHEERHEFSLRGRLPYAVDSLEVQVKRAYEQYKSRETNLLKNSFLQSMKAQNWTLFYSLLQAHLVEMFPIIYTPTEADAIADYSHLFRRSEGLYLTLPGEKNMEEDFLDACEGRELELIVVSDGEAILGIGDQGSGGIGISGAKAVIYSLIAGVDPAKCLAITLDVGTNNKDLLDDPLYIGYRKKRLRGDPYDQFVDKFVGLVKKHQPKCLLHFEDFGVSNAERLLRRYRDQHSIFNDDIQGTGAVTLAAVQAAIGVIKSSFKDQRIVIYGSGSAGLGIARQLRDAIALDSSCSPSEAAKQFWLIDKHGLIKKSLGKDKIRNEIEDEFIRDESDWGEGENGLDEVVKSVKPTMLIGISTQAGAFTEEVVKEMSKHVDRPIIFPLSNPTRLCEAQPKDLSQWTNGKALMSTGSPFDPVDIQDSDEKYIVAECNNALIYPGLGLGTILSKSSKMTDKMIIAGAQRLGQLAPALIEKDANKSLLPDFGDAQKVNFEVALAVLEQAMEEGVARAKDIPKDKDGRRKWAENNRWSPGYPEFKYDPEGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNM1</accession>
    <name>A0ABR3BNM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612739.1">
        <property type="nucleotide sequence ID" value="XM_066759252.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991645"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028977">
        <property type="entry name" value="Nucleolar_complex_p3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="8">
        <location>
            <begin position="370"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="7">
        <location>
            <begin position="711"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0245655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="894" mass="99929" checksum="41D39467F31A1830" modified="2025-10-08" version="1">MGKPGAKALGKRKALASKPPAPKKAKAAPAEDNTQANGRPKRKPDQPKKVKLRDQKTIPVPKSIYAQVSGDEDDGIDDDMLEDLGEEEGLGLENAKFLTGIDTTALSRSVKETKRLHELAKAREIIPQAKKHKSKTPVRQPGSDESDGFDSDPEFDSDLQSDMGSDVDFGSEDDGSLASDDEDDFSGSEDDEDITAVFDDFSSDEEEDEPERRKRKKKEEEAEYELAGRSRWAAKPEEPEEDSVEVGRLPIKLPTGEIQMVQGSTRIAVPQPKKPVAKPESEDEEEDDVEEEEENSDDEAQAKKMASQKGKFGKMGIAEIVGKKGWKNVEKLEAAKEQVAQLGSEILAGGELVDIGPVLIRLSSFGLPTVPALEEGQPLLSVPASIRGLVFLSQLAVYKDLIPGYRIRELTALEEAEKVRDEVKRLREGEKILVRSYKGYLKMLEAEIKGKTNLATISLRCMCELLTSVTHFNFSENIMGVLVGRLGRRSWDGDSDLVLQTFIRVFHEDVSGQHSQTLVRLIARMIKERHFQVHPNVLFCLLHLRLKDELDQMRRGKNAKGGNKGKGEKDEIKGKKFKSEKRKKWATKNQKKREKEMKEVQKEMAEAEAEVDKEERAQVQTETLKNLFVLYFSVLKNPKRTPLLPAALEGISTYSHFINIDFFRDLLVVLRKIIADQQLVDASNKQEEESEDEYAQQLDVVGTSQRIRNRLLAIATAFDLLSGQGEALNIDLSDFINQLFVLLRPLCLDTGIEDPPFLPASTKSSSGAVHTLSTSALLFRCLNASFFSRHSRSPANRSAAFAKRLTECALHFPPRTGKQAIAFARSLVSKEPKIEGLLDTEERMADGAYRPELDDPQLVNPFTTSWWEAGVLGSKHWDREVRLEMSKLRDGKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNM6</accession>
    <name>A0ABR3BNM6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612757.1">
        <property type="nucleotide sequence ID" value="XM_066759270.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991663"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="95" mass="10554" checksum="333F5663A6EA59C4" modified="2025-10-08" version="1">MRIREISLKEAKDDEDDERQLDRLASSGTSDVSGLTFLQSSSNFGSEYHFQVSSTSSPPTSTILTAREDDETLRSEKQTGREEVDDPGSCRSIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNQ2</accession>
    <name>A0ABR3BNQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_104819</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612769.1">
        <property type="nucleotide sequence ID" value="XM_066759282.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991675"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="11">
        <location>
            <begin position="637"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="424"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0245685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="720" mass="79784" checksum="B14ABBCC7433DB6F" modified="2025-10-08" version="1">MRILSWNVNVLRTCLDYHPFSSMKKKNIEGLLDELDAQIICFQEHKTVRTRLEKSMACPGPYDGFWTFPRSKTGYSGVCTYVDSRYCVPLKAEEGITGLLLGDRLSTMRPPWTDVERIGSYPDVDDMDWMDELDGTKFDVKKLDIEGRAVVCDFGLFVLFNLYCPNETNDARRPYKMNYLHALRERVHLLQAAGREVIIAGDINIVRQPMDSGEGPVRSSAEQHYSHPARRILDNWCAPKGPMVDVIRESWPQRDDMFTCWNQKLDARSANYGSRIDYVLCTPGLRPWIKGGDILSNVYGSDHCPVYVDLHESIVTPEEGILYLRDMLNPKDRPPSTSPVYPNDVKREAPEPPRFATKFMDEFSGRQTSLKSFFGGGSKRAREKTNAASCTANVSASASASSAPTPTASEPSLVAQNIASIPAASESAPSKVVSPPQAPEESVSTPFSLARAAFSSLDNPVPVRSQELYSKGSKGTPVEATSSFNQEKSSAKPIDMTLDDDEDDEPILISSKSKNRPAPKPTRSSSGSKSASSQAKLSSFFCQPHTEGKRKSPPPLSSAPPTSKRPSLAPLPQSNNDLLVASPSGTTAEDESQGMTEEENQLISQAIAEADAERAEKNAKAAPQWSTLFAKKLPPLCTVHHKPCKDFIVMKPGPNKGKRFWLCSLPVGAGYDMGRSKRPREDVNPKFRCNFFLWDSANSRKETPNGQEEKKEPDREEKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPG5</accession>
    <name>A0ABR3BPG5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613041.1">
        <property type="nucleotide sequence ID" value="XM_066758593.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990971"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="425" mass="46423" checksum="5A2ECA11C6E6A50A" modified="2025-10-08" version="1">MAQTKPVLVIYGATAYTAQQLFTYLDEHPEAEDFDFIIAGRNQTKLDKLNENLKTKREVIACELNDEEGVEAMVKRGDVIVNFAGPYRWHNAEAIIRASSKAGKHYVDLCGESAWLAKDIIPKYHSIASSTGACIVPSCGFDSVPSDLVVYLANQTLQKVRPGSTLADSTSIFKVKGTISGGTIQSMITLTELPKEERRAGEFSLCPGVQLPSTPPALTFSLPSTPLTPARFASFFFMYVYNRTVVRRSQFLSGALPTKSGGKVMKYAEGLDFGYGKFVSALATIGMMVFGGMFFGFKCLRNIILRYLPKPGEGASLEQLKTGHYQVTNLSIEEPSIPDHKPVKILTKFEGDGDPGYLNTCYMLAESALSLVLPAPKDTCRPPLAKIGGLLTPATAMGDVLVERLRKSGKFQITSEVLSEEKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ49</accession>
    <name>A0ABR3BQ49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613281.1">
        <property type="nucleotide sequence ID" value="XM_066758833.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991212"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF66">
        <property type="entry name" value="OS04G0158400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="626"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="907"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="520"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="741"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="866"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="912"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1022" mass="113374" checksum="F74F1F2CBC9CD026" modified="2025-10-08" version="1">MAAQAALGPCILGSPPSVPTPAKQLQVKKRVVNLVNPADELNFSQQSTSPIGSPTSMLYRDEFIKAKTPSPPILPRLSELQQQAGNLTPNTSDVKGILRPSGTPGSGNGVRFFHKKQFRVITPNSSVLAPSPAKPPLTPTSSSFFSQLLAVTMSPRLKEPESEPEPEENEESWEKPGEEGELSLVASIGSAGSIIIDSDKDEEDVKEEESWNGEPQIHCSPLGLPAVLAGNTSKDASYSQCELPSVEWHLPEDISNLLSTKFPEKGSFSVVDPTSTSTIAPSKDLSADRSSFRDALTSEAASESLKHISMENRSAEGFWGLHPDESTMSERGKEDTNPTIRCQLLPREEQVSTIEEKSETQESLLPIQLGRPTTPPYSASSIFADMSAEQAELTWPLAHRLGPDASSTFHSPTRIQSPEPRKAAPQTPHTTVGDVTEFYDCTAMVISPSSDSPIATCSASASLSSLLVQPSKALFEAQTAHANALSTELELYKDLTEKLHNEVSERDEVLAKLNMRALEAEMLYSQVQDLRKELAVAKTKAEQAQIQAQIAQQQALPSLGLNSPTPLMRTRSAALPSDRTMAAEREARDLEIRLAKALADSAATSGQLDEVKKSHDQQALELEEARAELRDKDDREKSRMIKASHPEESEKDGEMEEMREEMEELQRKLREMEGKEEEVEVLRQELVEVHRQLAEVKDGGNETQVLRAELSSAHHQWDEYELTKADVDALQKGISHLRHHVDELKQVKAADEEEIEALLGQVEKLKGERKQEEEWKNRVEELNRRVDMEGIRRQDVELKLEEVKTREVKLEAENRELRKSLQSTREQLVQAQSASTISPTDVRELQSLRIEVNHLKSQSASKDLEIINLQRRKAELKEDREMLNIALDSKQQEVELMKRKFGVRGVAGSTPLGASQRTNLDRGTTPPTTNESFLPKSLTRRRSSLAIHTPVLEYSKRHSLETPLQGNHRHGPQLYPSTKVTSRVMQRSVSKEENTPPSRASVGGSVAIYGSLRTKEREMTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ55</accession>
    <name>A0ABR3BQ55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612108.1">
        <property type="nucleotide sequence ID" value="XM_066759461.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991857"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF52">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="37"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0243741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="542" mass="60169" checksum="815D63E6616FEF55" modified="2025-10-08" version="1">MTVGQASSFADIPNNTSRYWFKDRGLKANVSHCLGLCCVIYYLANRKAIDDASLLNGLQAIRTWEEFLHYPTGNLLGLYAASFFLPTIFTAYIGDYCARRLGRRKTVALGTSIILGGSLINALATNPGMWVAGRAIIGAGGGIAKVATPALIQEIAHPRLRPTLACCYYPFFYFGSLFSALLCFAGLYIPNSWSWRLPSIIQVVGPIVVLITLLSCPESPRWLISVGRREQALAMLAKYHANGVMDDPLVQWELAEMEAALAQEQHNHQVSYTDFFKTSGNRRRLMVLISLSVGSNWVGNGVISYYLTPVLKSVGITSAVQITLLTSGLAIWNIILSFFAALHVERFGRRPLFLVSIAGMLASYAFVMGFSAGFAESHKASLGIAVIPFLFLYFGFYDIAWTPLPVPYTAEILPFNMRTKGLALFTSTGTLANAFNQFVNPIALKQLHWKYYAVYIAILIFYFVLAYCAYPETKNYTIEEVSMIFDKQKADIQHLGEHAIQEVEKGTTGHFEHQTVGSLEQKGITSHIEVTSIKNDRDRMMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQA7</accession>
    <name>A0ABR3BQA7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613045.1">
        <property type="nucleotide sequence ID" value="XM_066758597.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990975"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24926" checksum="B7E1EA89305324DC" modified="2025-10-08" version="1">MDTPAWDTQFPIDSQRGFEICEIVNFNSFHPSNYSKWVSLVTRATSAPPPVLVVPTTERRESSNLVYRALRLDSGNFAWGSESITRKTRLIQVRYNATNNELLRTQTLVKGAVVDIDATPFRQWYESHYAQPAFRGAKSAVTEEADKKQSNHVKRILEERKKVAKIDPLLEQQFKAGRLLAVISSRPGQSGRADGYILEGKELEFYHHKLQVRKAKHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQH5</accession>
    <name>A0ABR3BQH5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 12">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_104479</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 12"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613403.1">
        <property type="nucleotide sequence ID" value="XM_066758955.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991335"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15526">
        <property type="entry name" value="PHD1_MOZ_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="74"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="342"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="128"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="263"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="559"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="625"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="708"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="786"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="711"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0247442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="955" mass="106597" checksum="7B1520071486553C" modified="2025-10-08" version="1">MQTPVHHGHRLHGQGAVIREDFCSFCGGTDTINKQGVQETMVSCAACGRSGHPTCLNMLTPKLRKRVMMYDWHCIECKMCEQCEIKGDDSRLMFCDTCDRGWHSYCLNPPLAKPPKGSWHCPKCLSPPAVSSASISNPKSAARPSKSRPQPSKPGKTRPASTPNPSSNRRRPKQSLAGDDALFTSHRIKVKIPNPDSQYRDSEEGRGTPMIVRLKVPKRPVEEEPEEEKVPYGGVITGDDADTTRTKITKADKEAYEMARKAAEKQLGGPIPARETSRPGSPIPMASPSGKVTPSSKFPATSRPLRDRLLHQTLPEAYPFPSTPGPSTPGATQEVTPWTGSARLEKIKTIRFGPYDINTWYSAPYPEEYAYVPDGRLWLCEFCLKYMKSGFAATRHRLKCKSRHPPGDEIYREGAVSVFEVDGRKNKIYCQNLCLLAKMFLDHKTLYYDVEPFLFYVMTEVDELGARFVGYFSKEKRSMDNNVSCIMTLPVRQRKGWGQLLIDFSYLLSKKEGRTGSPEKPLSGLGAVSYKSYWRFTVFKYLLDAISPSSNHTLELPRISEATPGPTSEFDFKCNPDTKPTPPRITSNGISKATSMTLEDIFSTLSAEGMINVLDDLTADTIEKIPSRARARGRSRGRPNVNRRKTDPNGSGTPDPQRHQDEDDHVKIPKRYEILLDKAYIQAVVEKHEKKGYLKLVPERLKYHPFLVARQTEERGSGGKNREEEDGNEEEGEEDKGNEDESENGVVRFVDSIAEAAHIIAQSHKHLHPVPPSTVSCTSHPSVYSIPTPNHNPIPDPNTTSPARNLRKRKPDVALETPVRQLRSRDSMRGRMGTSPRTLRKRNAVALGEGIAEEGEGNQAFSKLNRLPVKSVTQFADGEIPIDPALLEESITLDPSIYGSVGEERYDDDAEGEEYIGEDDDAEGEEYIEEEEDAEVSGFGFALTLYIIVVHVMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQQ3</accession>
    <name>A0ABR3BQQ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613195.1">
        <property type="nucleotide sequence ID" value="XM_066758747.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991125"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="530" mass="57022" checksum="473E9A5AC8CC438C" modified="2025-10-08" version="1">MPPSKTAKSAALKKRPSRRRIITTESDSDDESPVQATAPASSQQSVEEHSSVSAEELGSGGSDSSLTSAPSPIQVKRISAKTQAVPKAKDVEKEEEEGGDTGDVAASVSDTAKGSATRTGRQTRARTRMSEVGSAENSEAPSTAPTPAPPAEDLDAFAANKSTGKDLGNTSSKNISLKVKVGGATATKITASVEDDIEGEREKPVMKMKSDMEKKNGKRTSGSVDEEGLEDADLRRAKMKKVGKVKDDTKGTEGDDEDGVKLRMDEEKKPTKIKKKSRRIVIDGENEDVTSTPDPSMTEITTAPTPKPTSPARALSPVKTSRSNDKPPSSSKAKRKPKPKPKAITKLEGTEVSHKKTPFAGSVNGTPQNKLLSAKKTPSGNIKRPSGSTTSTPTNSAPKVKPTALGGSLLAQTLNVLNSKQGKDEKEIAKGKEDKREKERKERGRFGWYDEWVLSASEQKEFDESRAKREAERKKRDAYGANMLNLQGGQDAFRIDNSQPSPAIFDRLDPKEINTRNDLPSQMLQKLLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR01</accession>
    <name>A0ABR3BR01_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613586.1">
        <property type="nucleotide sequence ID" value="XM_066758184.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990558"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20279" checksum="F57A655AB8ED1F8D" modified="2025-10-08" version="1">MAIIWFKQPVHTVQALGIALTGAGLWMYNNAKRDVDKGEIKMRHVEALREGVLPSTKMDPCILEGSDVELSYKSTHNSPKPVYPNNYIDLPRSTTTAVNKTTFQVPSILDHTSHIEAPYPSPPTSTSSSPPADITYLGVSKGRQPRLSSEGERFRPPVLNSIRSSAMEEAMETGVNDGMIGVVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR19</accession>
    <name>A0ABR3BR19_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613592.1">
        <property type="nucleotide sequence ID" value="XM_066758190.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990564"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="62"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="365" mass="40835" checksum="927355D4FE7EAFAB" modified="2025-10-08" version="1">MISVEKLKSTLDFFSAGNKLSKAFRLNVNHDVLRRSNEDRFSMGNPFADNHDYGKPSLPRSHIILHSVAMFFTFIAVCTMAAVAGFQAKWFSVSGGTGFVLFLLLLSLFLTIILTIVPIVYDRWDRLNRPAQFLAQTRSTLILHAFGTLLMLLAAFIVTISAWTEKGCKNPSNDPHSDLGDSYKSGLQNWCKTKKASAIFDWFSSIAWSILLILTILAFRREQKANRRELMVLPPASDGISYSNIQPADEEQLDDKSESARGYTPDVYRKTDTTYHHPASARTVHSPPSVDHHPMLSRTSIDVYGAFDGDGMPRVDEPSRTMQLAYTDPYAQIRQSLMNASNVTQSTHIPGISFGPPAYAGYRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR77</accession>
    <name>A0ABR3BR77_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613655.1">
        <property type="nucleotide sequence ID" value="XM_066758253.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990628"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="222"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="363" mass="39272" checksum="87228F3DCEFA7981" modified="2025-10-08" version="1">MGRVHILGVGAIGTLVAHHLRLAHPSLPLSLLVRNASLFSDLSVTREGITSISSNYDFESPSSEGPHITSLVVALKTTQTLSAIRPLLPRLGPTSVVALLQNGMGVYEELCEHLWPENVNRPFFVLGTTPHGAAPAGGKGVIGHYTAAGHGDIKWGVVPHPRGTTDLLEKWLFGSNSSVVKSPSQLPAVPVDSEDLTNLHFTLSALLSTTPLNPMLLPYPQLRLALLLKVAVNAVVNPLNAILGRGQYRVDTLSTCSGGTALVDAVVDETSKVILSYLQTQSLPSEELQAFQSHVLRQHLRHIITSNADNTTSMAVDIREKRLTEMDYINGYVVRLGKKTGLETPVNEMLYNMVKFIESAYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRN5</accession>
    <name>A0ABR3BRN5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613636.1">
        <property type="nucleotide sequence ID" value="XM_066758234.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990609"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF3">
        <property type="entry name" value="CLEAVAGE_POLYADENYLATION SPECIFICITY FACTOR A SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047522396" evidence="3">
        <location>
            <begin position="26"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="572" mass="60147" checksum="955076DF185EF417" modified="2025-10-08" version="1">MICLLRHHLLLTAAFWALFPKAAFGFSFTLENSSPKQCEEVEIKWSGGQSPWSLTIIPAFDYPTTVSIPTSSYDNNTNTGSYNWTVNYPSGTNFVIMMSDGSGTGTGGVSPLNKVSGTYSSSCTLRSTSTDFLFYLNETSLTQCEPVDIYWDASAVSPVSILGAIPGGQVFQLVSTDKAATSLVWNTNIQSGTKVILAAFDSGTHQQGGSSDLLTIQGSSDNSCIDSSSPSSTSSSSQATQTGTSANSGGGTKTNVGGVKTVTAITTETASPGGAAGLSTGAIVGIVVSAVLAAAVLQIALIWFCCRRQIKALIYHRREMRGQEVKPGGDVDLGLASRNSYSSVRDPDQRTMTGIYATEATRSSRYSNAARSGVPLSGSGDDFDAASSISPFWDGAAAVPPRSNSIASMAASNRPPTIGALGFDSDTDSLVPPRALSLHDRRRNDSLSSYSIIVPETIGEGDYPSPAISNTTLSPLVPGSPNLAATGSNSNRNMTKAQMAASLNAHNPDESAPTGDDFEGRLPPQHAPTGGFRRHEDAGRIDAPPPNENEESVEDLPPMYMPEWENDSQRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRY8</accession>
    <name>A0ABR3BRY8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell division control protein 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_103991</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613874.1">
        <property type="nucleotide sequence ID" value="XM_066758472.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990847"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0247913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="196" mass="21661" checksum="C22A89CB5C160321" modified="2025-10-08" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDSPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLICFSIASPASFENVREKWFHEISHHCPGAPCLIVGTQVDLRDDPKQVERMMNSHRGGRAAGLITQEQGERLARELGGRKYVECSALTQKGLKNVFDEAIVAALEPPAVKKTKKCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS48</accession>
    <name>A0ABR3BS48_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Leukotriene A-4 hydrolase/aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_103061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613947.1">
        <property type="nucleotide sequence ID" value="XM_066757563.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989917"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="10">
        <location>
            <begin position="485"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0249760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="632" mass="71088" checksum="91C3C3F709B5AC1E" modified="2025-10-08" version="1">MSFHPQFIPPSAHIDRDPATLSNYLAIVTKHIGLDWTIDWDKQVFGGSATLKLEAREDGVKEVVLDSSHLDVSNVEVDGEVAEYKLGKTIEVMGEGLTIILPKPVSKGSSVSMKVTYSTTSQCTAVGWLTPQQTKSGKHPYLYSQCQAIHARSMLPCQDTPAVKATYSAKVRSGRGLEVLMSALRRDTVDLGDGVTEFVYEQPVGIPSYLIAIGAGELTYKPFDKLSGRNWDTGCWTEPGNMDAAYWEFHKDTANFVATAEDLASEYKFGVYDVLFLPESFPYGGMENACLTFATPTIIAGDRSQVDVVAHEISHSWFGNGIGCASWRHFWLNEGWTTYLERLIIRATHGEQARQLSFTVGRRGLVDDLARLEPRFQRLVAEYKDHEDPDEGYSQVPYEKGANFLYYLEQTVGGLEVFLPYMKDYVKTFEGYAITTEQWRAHLFHYFGSLKNGEEVVRKLGKVDWDEWVHGDGSDLCVDIKYDDTLSKACYDLAEKWNHARESEDFSRFSPKDIENFSSTQKVIMLDRLETYPALSPKAVSALDNAYSLSSTGNAEIALRFFEIALKSSADYAQKAAEWVISKGRMKFCRPVFRLLNEQAPELAKKTFMEHAGFYHPIARKMIAKDLGLKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS52</accession>
    <name>A0ABR3BS52_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1764-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613971.1">
        <property type="nucleotide sequence ID" value="XM_066757587.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989942"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013885">
        <property type="entry name" value="DUF1764_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066:SF1">
        <property type="entry name" value="DUF1764 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066">
        <property type="entry name" value="GROWTH FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08576">
        <property type="entry name" value="DUF1764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19827" checksum="1A81F84512B65944" modified="2025-10-08" version="1">MPKKISAAATSKPDKPAQATATDIDDIFAKPKFSKSKPESVVEPEKKKSKGKSKAVSTEEPAAVPIDTEGGEKKKKKKKTVTAFVPDEDGQESSSKVETVVDPSTIPVIIPEPPATAKTKKDKGTKRDRKEDEDDEIFRDSRGTGPRRKTEEGFLIYKEAELKIDPEAGGTPLCPFDCDCCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSD1</accession>
    <name>A0ABR3BSD1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614045.1">
        <property type="nucleotide sequence ID" value="XM_066757661.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990017"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="111"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0249858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="306" mass="34867" checksum="9714DA7D3F02C0D2" modified="2025-10-08" version="1">MSANDDVDAWIAQLMQCKPLSEPEVKKLCDKAREVLMEESNVQPVRCPVTVCGDIHGQFHDLSELFRIGGNSPDTNYLFMGDYVDRGYYSVETVTLLVALKLRYRDRVTILRGNHESRQITQVYGFYDECLRKYGNANVWKFFTDLFDYLPLTALIDNQIFCLHGGLSPSIDTLDHIRSIDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNHNNGLTLVARAHQLVMEGFAWSQERNVVTIFSAPNYCYRCGNQAAILEVDDSLKYTFLQFDPAPRAGEPLVTRRPPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSN4</accession>
    <name>A0ABR3BSN4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF2428 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614141.1">
        <property type="nucleotide sequence ID" value="XM_066757757.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990113"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUF2428" evidence="3">
        <location>
            <begin position="284"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="4">
        <location>
            <begin position="539"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0249954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1152" mass="128016" checksum="D81612604C693F0A" modified="2025-10-08" version="1">MSPSHPTPRLEKLETCRKALLKASPQELQDVGLLSDAIELILSPQEEKLHLKLLELLLVLLRQVTIALSLSPNESVRSLAQDRLAPEFQPGKPLIVFLLANIDHGLKVQQTRSVEVLAAAAKLAITISSQDILVSSASSAAQNNNFMVPLFTYIADGDVTNRGDLSVMIALLPYIPPSAIPSKLLDRLLSELHVAHNASRNEALSTAGARSAFSSATYAFFVRLHQARKILDDAKLEKGVGVIERDLVQIEHHPLHGLLGAIKDVILCLNIETAEAQQTWSPIFRLLMSLVTRIWNATRAVISLAPSGLVSADENGMEGSARPDHEIARAYEVLGGGEDGEEEDGMDHTGLLSGCWRATMTAGELLAAIFTLPLARSGPSQLIWSVEDVSTAGETFLTWLHEIRHRGTFSKLANAFAQLVEAVRPIESLQNLCDDWLTDELKAISSDQHSTTRRSAALPYSILSIVSNSEVLLEKAMTSLLEFAKVENASTSNVTKVHALNVLKIVLLDARQAKWFDVWFERSVITALKAFESPDWNVRNVGLILFSTLVHRCLAPPRGGQDYYRSRTMLASRKPYSLFHNKYPLILPFLMGYLTKGSDPDCQTRNRHSPLLPILIIVRSLKWSDKNAEMLSNLARAVEPYLGSREYQIRQTAAQALSSTISPSEALKRVLSIENYFSPSPEMINATHGHVCLLRQLISNFIEWEAVDAESLARIDNILLRLVKEYIPETHPTITADIIGCVESYLTSTGVDKDPLVTEITCRAQKYMNRPSPAFVPAEEFRLVACTAVLSTHAASPSIILSLLGSSSSEASNIFILEHLWHLRESYSPELLDRVISLGLRGKAGEGVQLKALNVLSEITWQSMDCDILAEWKEKGGRFETICEALDRILINSKCVPIREAALVALGWALHHALNDSAGENKWVISMYERLAQYVLRVSHEDESQPARLAAYKALTHLTTHLIHLPHSSFHQTLIRLAQDDDEEIRHGAAGIIVGTLGGEKGVVQQRAVEMWYSWATRFLSSFDRNSDGLGQWLTWISDLAEDHKGYEHDIKTLKGGVDSEVLFEVEPSNIFRDPLVDVFYASKLLSNLRLAGLLDDRSSHRVLEHLKLDSVVEGLCVSPIDDAWEARRSLVRRQEYQMIVVSKEGDWQESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSR0</accession>
    <name>A0ABR3BSR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614171.1">
        <property type="nucleotide sequence ID" value="XM_066757787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990143"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="81"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="271" mass="29539" checksum="D250E85366104FCB" modified="2025-10-08" version="1">MALPSSSSMSLRRSAPGVAASVLGRLPAQTRSYASPASASSTSSSYPPPPLPSSTSSTTPQVAQAYLSNLFSLPPSRQFNPALALQILTHKSYRFAHPVRHSQSLSEAQSPIAQESSAPHNARLAFLGRRALSTYLALFVHEAYGSSGALREQGSDFLRGKELEERLTALRHVNNLGRMVGGEWRVEDVLRWDRNQTAQASGNLSVKGQTVEAILGGVFTQFGSPAAHRAFHLHVLPKFVSQLRDPFLVEKVETVREQLEKEFGRGILPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSZ6</accession>
    <name>A0ABR3BSZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell division control protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614257.1">
        <property type="nucleotide sequence ID" value="XM_066757873.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990231"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="78650" checksum="AD1DE2E610228406" modified="2025-10-08" version="1">MPVVQPPADDLRPSDLTYTHAYNSIVSRVRRTAGAASGGVVILAGVDVDGLLGARILCSLFKNDDIPYRLIPVGGLGELEEKSDEALASEEIHTLILVSLGSLLTLTDFFSLPKKVHLHVIDSHRPWNLGNLFDIDLDDEDDEEAHGKVWIWGDGDEFSENMDQLRKSFEALQFLPQKDSDEDSDSEESQADEEEPEDEDEEGDDNEEGEEGESRKRRREDSAPARRKRLRDDDRPRKLPKAIKEAHQERIAKYYNHGTYYGQSVALTIYLLATVLERADNDILWYSILGVTHQYITSHIDREKYEEYHTIFLDEVVRLNHEPDPGALRTPNPDNRNISNSEELRFMLFRHWDLYNAMLHSGYVAGRLGIWKEKGRSKLRGLLAKMGYSIQQCNQTWSHMDMELKRQLPEVLERVGPEYGLVELSYPSFTRAYGFQLSSLSAADAVEVISSLLDIAVGVRLEVDREGGKGGGEWFGGTTRWSVGTREVEMGIAPSEPGERAEGTEGEESQEKNDQDWHVTNFWIAYDACNDVSLLRRSLPLAMALHRAIIRAGSDLLDKSIIRTLRNFRLTILSEGPDLRLFCHPSPLSRLALWLVDATRDRWVEKLARQNSHSGGKVKSLPFVVACLNEEKGTFSVVGVTGAPEFGDVRKNKFGLAFQQAAAFSNATASLDMFDTSVVEVGREDLQSFIEHLHLHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTK2</accession>
    <name>A0ABR3BTK2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614466.1">
        <property type="nucleotide sequence ID" value="XM_066756997.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989309"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21558" checksum="47A624C735CF665D" modified="2025-10-08" version="1">MDPRSSVPQVPLHLTSICILSPSNTPLYVHSFTGEQDELRHYHLNHAAIDVLEERLVMTSTPTRPADSYLGLLYSLEDMAFYGFQTTTKLRMVLSISMVDAMIKDADIVAIFRSVHNLLLIACNNPFLSLPPSFHAISANKSADGEAQNLTNPTLPTSKMFATNPEEIKPIWLKQSRRFTEGIKAIGEMLSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTK9</accession>
    <name>A0ABR3BTK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614173.1">
        <property type="nucleotide sequence ID" value="XM_066757789.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990145"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="553"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="757" mass="81782" checksum="95039C33D44AF82D" modified="2025-10-08" version="1">MAYYQRTAQQGRPVRYRLEPMYAASNVEWAFMNVLLTRDPEYVKQVIRSYVDVKQSHGRSKLEISLKLEPLEREYPQFAQSFVEVRMERGLPQSRVISLRVNPPNPLHRASTTQSQSPNRPSDTRPGGLRVQSTTANTSRRASAPSQSARPPVVRNPEDGDELPPPPYSSQDPEPEATRILQERLAAETNVEPSTTVPSSSTPQAASNPAPASAQSSSAPNSESTRPGLIDSNPPSDPQMAQVWEESQLDEAKRASLAWREQQELEEAMRLSLAEAEAAGVGSSTGPGTSSHAQSEQDRLPVVNEDEAASYGEASSSSQPPNPDLMGLVGGLEDLTFSNSEQTSSASHAAHNQSSILDDDGPSGLNQQPLVPSKTGLVMQSKNPFLSQAERETSNADGSSSHLDSSTSAPAQAGASELTPPARQDSPGSTHTSQTSQPIYAPPPGPPPPHLRISTPPAQSPSSTQNQTSPASRPLPRTPVSPDLSSPPVPQAPGPQKYSPQLASSSQQPSASTANGVYASPPGLPPRKPSRGKSTYVPPTQGEDPLEMLRDFDTVFLVDDSSSMKKDQRWDQACQAIMEVADLASRYDDDGIDVYFLNNKRVGKELRSSDDVEELFTGLGPRGITPTGRRLEAILRDYMSRLEASQHTGEEVKPMNLIVVTDGAPTDDPESVIITIARRLDRGQYPLSQVGIQFLQIGNDPEAREALQELDDGLSSEHGIRDMVDTVPFSGEEMNAGLIIKTLLGGINRRLDRRSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTL5</accession>
    <name>A0ABR3BTL5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613323.1">
        <property type="nucleotide sequence ID" value="XM_066758875.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991254"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045398588" evidence="2">
        <location>
            <begin position="20"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="449" mass="45414" checksum="186EA7B267C6ECB6" modified="2025-10-08" version="1">MKISASLIALGAAASVATAQNVSIPGLTSSALHLLSSSCQTAVKELLSPNSPTGQCLNTTAAQTVLNSNGSVVPSVENWLNSICTSNPCSNSTLQNATQTILSQCSTDLQKFGVTNETIKVIVESYPLAREVVCLKTTEPFTSNSTSNNSTSGGYGGASSSASSWASSATGWATSAWDSATATSSMWNNGAGTDAGPSASFAAESAYKLIRRQPAQGSGSSASPAVFSTSSAASPSSTASSSGNSTSNTTETYCLISVIDELSYYLGTNLSLQEIATIALGGNATAVQTLASIPPTALCNDCIFGALSLAETEFPDVGTSIWIGNTTLNQFFDTTCNATGLVISQNGTLPHNVTASAYNSTFPYPFVNGTSTYSPTSTAAPIPLQSVIPNHNVTIGHTTVAFGNGTRGSSSATSSAASKSTSSSKSTSSSVATAAASNPAAVKARWMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTP5</accession>
    <name>A0ABR3BTP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614371.1">
        <property type="nucleotide sequence ID" value="XM_066757987.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990348"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046617850" evidence="1">
        <location>
            <begin position="17"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="214" mass="23444" checksum="4EAA20F4D4C714A0" modified="2025-10-08" version="1">MLSKLTLIALLPLAFSTAIKKSSDTLNCVQFQYGGPFTSFGAGGFIHLYSNVTSFDSSTQHSDYNETRLGLAEDGTIENCGDCRTTELFGFEVCQNDQRKGFDGLSNGPHAFYGHVTYTNVSPNIQCLTATKTPYEGASLRLADCQYDYDSASTSGQYFEMTVTDGVYHALLIDEASNFYGPTPELNNNASLVLYNVVGPNTTYTYFGFKAPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTR1</accession>
    <name>A0ABR3BTR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSN8/PSMD8/EIF3K domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614528.1">
        <property type="nucleotide sequence ID" value="XM_066757059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989371"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="2">
        <location>
            <begin position="103"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="288" mass="31758" checksum="1BB7E9C3EC022698" modified="2025-10-08" version="1">MSLDLQQTLAELQAAYDAPASSEQLSTQLAKLKLELAQSGLYFAPPSADPQDLIAARSILEIGAFHSLRQGDLKSYARYNFALQPFYDNLRDIIPSSPNRPVTLGLHLLGLLSENLLTEFHTLLETLKPEELNDSFVRLPVDLERWLMEGSYNKVYRARDRVPRPEFEFLLERLMGTVRGQIASTIESSYPSLPLQHAATLLFFKSGETSSLTDFASARGWSLSPNTQTFSFPRSSKPDIALAAAESNSDVSSATIDKLKGTGVVRGVPMETMVGPALRLAQQLEAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTT0</accession>
    <name>A0ABR3BTT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 6">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102513</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 6"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614527.1">
        <property type="nucleotide sequence ID" value="XM_066757058.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989370"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="228" mass="24744" checksum="A791518166AF36CB" modified="2025-10-08" version="1">MKAVLQRVINASVTVDGKIISSIGKGLLVLVGIDRYDEPQDATQIIKKILTARLWEDENGVSWKKNVKDINGEVLCVSQFTLLAGFKGSKPDFHESMSTIPGNAFYSSFLKEIKTAYDPSKIQDGQFGAMMQVSLTNDGPVTILLSSKDKPEKSGTTTPTPSATASGISTPLEGKKKNKGKGKFMTENKIDRQLGETKNTDLLGTQQDISAAEDKIDKLSVNENTSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTY8</accession>
    <name>A0ABR3BTY8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613755.1">
        <property type="nucleotide sequence ID" value="XM_066758353.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990728"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF8">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 12, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="82" mass="9578" checksum="B4AD74D0C1A448ED" modified="2025-10-08" version="1">MSDDKTFVLQTTGFDARFPNQNQTKHWYQNFVDYHKCVNAKGEEFAPCQQFKKAFRSLCPNEWVGKWDEQIEAGTFPASLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUF9</accession>
    <name>A0ABR3BUF9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614671.1">
        <property type="nucleotide sequence ID" value="XM_066757202.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989518"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="185" mass="21209" checksum="4EA1835FFC0B98EF" modified="2025-10-08" version="1">MTGNTSVSDAIKHDHRELEQYYDQIINATDADTKTRYQNLFTWELARHSIGEELVVYPALEKYVDGGKALADRDRQEHQKVKEMLYKFQQLSPSDNQFEPTIKRLMSDLAEHIKEEETEDLVKLEQAVPTSESRSLAASFKRTKMFVPTRSHPSAPDKPPFETVAGLLAAPIDKLGDIFRKFPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUG5</accession>
    <name>A0ABR3BUG5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614767.1">
        <property type="nucleotide sequence ID" value="XM_066757298.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989619"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF4">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="465"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="919" mass="101472" checksum="476599AED695422F" modified="2025-10-08" version="1">MRFREIVTSPMWETIGPFPSGTRELPFLGSPLATYSTPSADPDIEFAHRPYNPEETWPSELGNGGRVSWSKFEAKGDWLEISYPDINWDQLRSDHGWSALQYMVLLRTRLTIPKSGHNKPLTPILINMLQLSEFAFVQQNADPHTSGPVKWYQGNSYGFGGPAPGLNSTNSTNLAAAKFERSLLLEPGAYIMLARAVYDIRQFGDPGPGNPPTIKMSSANMVHDTEKHVTQLSQEMGAFPSVFSGWLMGEWASVGIRVPEGALETTVIGVGKMEIACKSKNAEPLKSALAVEIVSDIRIIPGQARLIAMRIRQKTPLSPETRTLTISIDFQSGGTTRVLEWSIALHHVTYDNHSSLAAKNSHWITFASPSLITDSHLSHLPAHVSSAMIVPPKRSVRHDAETPPVLLALHGAGVDVKNSEWGERMPDVPGAWAVLPIGKNEWGEDWHGGSMEDAWAARAAVEVQLGKVGIALSNKTVIIGHSNGGQGAWHLAARYPDRVVGVVAASGWLTIQHYVPYTDYISNRYADPALMGILFSSLAPYHNDLHSSNLSDIPILAVHGADDDNVPPRHSRAHAALISSWAGEKDSMVKVLEVPKKGHWWDDVLSSSAVVEFIQQLPPRQSWDEQRKKGYTVTTANPQECGGRAGIRIVELDTPGRLARLDVNARQWKLDQTAEPLDIRGMNVQRIEIKSLQSSQHFQTYVKRRPYGFSPVNKSILDSLAPPRAYGPMMRILSSPASFHLVIPSSREDQPQHLSIAKRIAHDLYVYHKADCEIIPDHEGLERVAKGQIGPGSIIIIGRPEDNRYTEWMAAERKIPIQFPTQGVMIINKDKVVYDRGAGLIALHPHPTHSGSLSLLIAGNDELGLELAARLFPTRTGVPLPDWAIVCPRSRWQGANGLIGAGFWGSEWEYNEAMSWMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUV9</accession>
    <name>A0ABR3BUV9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614836.1">
        <property type="nucleotide sequence ID" value="XM_066757367.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989688"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256:SF1">
        <property type="entry name" value="GEO09626P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MLRQ SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10637" checksum="5328D7D5F8FA6AF7" modified="2025-10-08" version="1">MSINRAFMKKWFPVEVMPIFGIVGIACAGATAYLWKLSQGPEVVWDRSSDWRPWDKVKHDENLKYITVNPEFWAQRRAQAAAAKNGERAVDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUX4</accession>
    <name>A0ABR3BUX4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614944.1">
        <property type="nucleotide sequence ID" value="XM_066757475.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989829"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="365" mass="39675" checksum="3D525B379B68CF13" modified="2025-10-08" version="1">MSFPKTMKRYVLSHRNDLSGLTFEQDAPVPQIEKPTEILINIKALSLNARDLQIATNQYPAPHPIPDGIVPVSDASGEVVAVGDDVTDFRVGDRVTPITFQGHHQDEDVTLDSMNRGIGGARAGVAAEYFVCEQSEALKIPKSFSHQDASTLAIAYSTAWSSLYSHHPRLQAGDTVLCLGTGGVSLCAAQIALISGAKVILTSSSQSKLDRAVDLLKPLAKGDVADTIRTIDYSKIDKWDEEVHRITQGRGSDFVIEIGGRGTIGKSIKSTRRGGLVAVSGYLSTYKDIPKEILEEDLAQTILYSGSYVRGVFVCNREDEKRMISALEVGGVKPVIDKVFAFENLKEAYQYMADGKHFGKICITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUY3</accession>
    <name>A0ABR3BUY3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614851.1">
        <property type="nucleotide sequence ID" value="XM_066757382.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989703"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="758" mass="86587" checksum="EEA58FD4BDE457F4" modified="2025-10-08" version="1">MSSSFITKLEPHRRSSAMSSTSIEQPPLLGLPHEILEQIFLALSLTGRSKLARTCSALRDIYATSAQLQYLAILETSAYLDYPRIFKAIEPVEEEPLSAMSSPPSSPEAALTTVPIAFRSPHTGNLRSTIPSVSLAPWPKQAPEVSLLDHFGNLAAKNRRLREREERWETMEFKEKRTFKVQGQEGVYELQEGIFLLCNDTSTDDEERRPDTIRLIPLPSADDPDLEDPPISVKGHKLPMSIADLTMDPSQDLIVVSEYNPAPSEPSRPVPTHRYHLLTMSSFTPHPLASLPTLDFPPVTQTLPRTRQLLQVMGDTLAVLVAKYIPIWILDALNIDPEVLGHRTQEEEIVVWNWKTGRVLSRLPFTEKQWFSSFAMLSPTTFMVTSTMSSIPSGGPAFPWKRDEHRPTIQIYSILSDPKRSVIPVQPLQSEIMDDTTPRPVCVAVLEMPTLQEDVRVTEFDVRPDPAYPPRPEQTKDGEVEYTLLKHKPFTQDPSKGILVFDYRLQERIAMDPNTRDVVRNWPFEVFVRRETLVKLGQEGEKRLKQAWESGSVLKMGVRDVQQTFTWDEWGEKGARMMDRIMTIRSWVCSCSGYRYISVLSEDKSPFADYDLDEPLEDDQPTLDGHYPYRPGKSHILLYDFNPYTISKELSQQEPYPESDDVDPPRRRTACGETFVPPFTEGRGWKSRVVTEPTILSKKYIFEEDVRSELPYREVWREYGGWANGIMIDDQRIIVVNTNARRNGDWSSISQEMTVLCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVP5</accession>
    <name>A0ABR3BVP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614694.1">
        <property type="nucleotide sequence ID" value="XM_066757225.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989541"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="216" mass="24282" checksum="B2E43357A8AC2E34" modified="2025-10-08" version="1">MSKAQFLREYKLVVVGGGGVGKSALTIQFIQSHFVDEYDPTIEDSYRKQCIIDEEVALLDVLDTAGQEEYGAMREQYMRTGEGFLLVYSITSRSSFEEVSTFHQQILRVKDKDYFPVVVVANKCDLEYERQVQPHEGRDLAKRFNAQCIETSAKQRVNVDEAFIAVVRAIRRYQKESGPPQAMNAPTKSQTGAVGGRAAEKDDHVDRGCCRGCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVQ1</accession>
    <name>A0ABR3BVQ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614088.1">
        <property type="nucleotide sequence ID" value="XM_066757704.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990060"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="27"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0249901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="951" mass="105112" checksum="2A0B2A3CC93A537D" modified="2025-10-08" version="1">MFPPENIWNDQEQLVSYYVNNAVPIRTQPGVLIASIIVSVLGSYATLIVLGRRTSSRGWRNHLLLLLAAIVFAACAIWGMHFVSMISIRLKASPDVVWYIRFNDGMTAMSLLVPMVATALSFWVIGSELDFSIWRVLLAGGIMGLTVGLMHYSAAFKLPYLTVSYTAVTVVFALILAVVAATVALFLFFRLRTQWQDSWWKRGLCALILATAVCGMHYLGLGGASYYTKPKIDWRELTKSSQSVRLAIGISVMCAAIVLFCFLVALFDALTRRSIRNKARSIVVASASFDKTGKLLVKNDGTIPMQVISTDADLQRVLRELDPRQPTFQWLYQLSFNWSLVTPFVPRVLRSVFDRSRGIVKRASPLERGLPHSYWETLLFRSRFIEASVLLAQQLDLSVESLGAMFDRVLTTGTRAPTPEDKSGKAVEEGKASMKGDDESSIHGITLRMHNSEGVMLFLVREIGDGHPAAWDNPSADKSQLRSVDNVDSYTARGYRLAETRYFSKAMADHFGVSKQEMDVFLSACKTYAKRGTRPVVQSGGAYLGLFGVRPTGEKNNLDVLVYNFARHQIPAYRLPDVSYPLTSTMKAWVRELSNCPMGEVLQRCNDAVLQAEKSEDGMSLHSQVDEALYEFQSALAVAIEALATALRCWPTLHQIATLSPEILEIPASDNDDKPPAEMVVLEVILPAPDARLTPVQSRASGVQAPSLASGRHESDKPPAPFVYTPFSLFTKSQAMLLRARAFQEFSKSTSMDLNKVYPLVPTDVAAELDAYDRDEKCPDSNSNPFKKLYYSSKTGNNGLIVDVGDDENGIDESYHIPLSPMGSETTGDANEKSFSTLSPTLQSLSMNTSRMGNRRGTGQSDNSATPLQAPVESMKKGLSNLVHKAAEATGYYGEEDGEEGTMQEGSIGMPVYSSVRNKTDGWFMRSMRDLERADQTGMLDGVEWQPKGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVR2</accession>
    <name>A0ABR3BVR2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_101865</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615193.1">
        <property type="nucleotide sequence ID" value="XM_066756416.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988723"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="14">
        <location>
            <begin position="65"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="350"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="416"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0252473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="532" mass="60360" checksum="1C84E5C01A1DB0EE" modified="2025-10-08" version="1">MKLDATDLRYISADEFRVLTAVEMGSKNHEVVPSQLVAELSQIRGGNVKKALGDLAKRNLVARVQNVKYDGFRLTYGGLDYLALRTFSRRKPPSVHSVGTRIGVGKESDIYVVADEHGEKRVLKMHRLGRISFRAIKSKRDYLGKRKSASWMYMSRLSAQKEFAFMKALYQHGFPVPVPIDQARHCVVMSLVDGYPLRSVEVVDDPADLYSKLMELIVRLAHAGLIHGDFNEFNIMLLRKTGEPIVIDFPQMVSTRHENAEYFFNRDVNCIRRFFRRRFRYEATSWPTWKDVLEIETGNAESAIQEKSNDDLTDLPETQKRVRIDLEVEASGFGRALQRELEDYMIEVQDLPASEGDEEEGEEEEEDEEEEEDEEGEREDEALSANFQGIDAEVPSDEAAMAARLEALRLHRALGNDLSDEDADPDSEHSLTDPASDDDSDDSDDSTGVAQTDFTTYTPSTRNQPRHHARLPVKEFENRGGARSAIAKQVERERYQTGRKANAGKTSVKLGKQKGHKWKSSDKYMVGKDSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW22</accession>
    <name>A0ABR3BW22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_102461</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614475.1">
        <property type="nucleotide sequence ID" value="XM_066757006.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989318"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045635287" description="Non-specific serine/threonine protein kinase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="623"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="12">
        <location>
            <begin position="916"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="495"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0250288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1050" mass="115870" checksum="4C8B29B4C88F45BB" modified="2025-10-08" version="1">MLYFLLLLPLLFIAYAAPEPAALIPFPHHTLRALAPSSTTNLRVQIDHDLHPLVLVSTVDGALHALERNTGKEKWVLEGEPLVGGKIKGGVEEYIVEPLSGSLYVHENKDGEMKIRKLPLSVDQFKHTSLMSVDLRTGEQVDCFSPTANLSQYDGSSVCDDLDDLERGGSSQRDTLFIGRTDYRLTIHSPSSSQGLSTYTSTAYSSEKKSTPAIQEISYSTYTPNAYNRPLAESWIKAGVAHQSWGPDNEEPRIRIELGFNGKALGVKPGGGLIWNRELEHIGVGVYEILIPRENPMGAPILVPQPPAHLPALFPGQSDPRAYNIHDAPPSTYIATLPESLTLPASSNTTSSNATTGNKDIKPLHFALSSSSYPLINFARPPPPGRLSDGLFYNADDGDSSDLDHSRGRGLLSGLIDPPSEHETIDPPFIERRAESAKNWWWKWVVALGVLLIILGGVIVRFGRGKGTAPESVESKLDEKTPLLAAPVQEVVSLDDEEEQVLPVAKSAPVVRIQEPSPSPEEDSPPRSPGTPETDRTATPPPKKKSSRRRVRGKKKKPDATAAAASLMPDEHEGENDDEDHERDREDVSPQPTPKRSNKPLPELPRELSSTDLLDYQDKERLAISDTIIGFGSHGTVVLKGTWGGRPVAVKRLLSDFTRLASQEVKLLQASDDHPNVIRYYCQEKRDNFLYIALDLCQASLADLIESPEKYRELADQLDRKRALMEVTKGLKHLHGMKIIHRDIKPQNVLVSQTPSGLRILVSDFGLARRLGQDQSSFAPTANNLAGSLGWRAPECIRGVVRLNEGFDASSSVGSSGGIANAEDGVARSRLTKAVDLFALGCLYFWVLLSGEHPFGETYNRESNIVKGEAVNMGMLSLLGEEREEVEDLVSRLLSSEPDARPSTSECLTHPIFWPAAKSLGFLCDASDRFEIMQTEPPEPTLVRLEQGAQSVVGKDWYSRLDKTFTSSLGKYRKYKGGSVRDMLRAMRNKKHHYQDLEPAVQKHLGALPAGFLLYFTSRFPKLLMHVYRTVKESELRDESMFEGCFQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW52</accession>
    <name>A0ABR3BW52_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101924</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615252.1">
        <property type="nucleotide sequence ID" value="XM_066756475.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988782"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="232"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="808"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="661"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1019" mass="111779" checksum="3661634BD86CC230" modified="2025-10-08" version="1">MTGSIKAIDTSLIHRIHSGQVVLDLQSAIKELLENSLDAGATAIDVRIKDNGLDSIEVVDNGSGIAEADWESIALRHHTSKLPSLEDLHKVTTFGFRGEALSALAALCDSVTVVTATKETAPMGAVIKLGTDGRTIDTSGRVARPRGTTVTLSGLFGPLPVRRKEFERNAKKEASKALVLLTAYALVPASAPGQDTRNGVRLKVEMIAGGGRASKRSIHLMTDGKGPLRSSVGAVWGPSALDNVEDIDLSLEVEIDKVMARREGITERMQTVKVKGLISSAKWGCGFSTSSRQFFYINGRPCNLTKVARAINEVYKSFNTNQLPLAILDFKIPTESVDINVSPDKRTIFVHSEDCLIDSLKTALESFFAPSRNTFIVEGASRTVKSIRRDQSHTSLKQSQHSEESSQRQEGNASLEEQEGERQMASDIEASENVAVRRSLSRRCSQSTINVYSPPDEQIHLMKESLTSAATPTSSLCELNEPRVSSPSSQVSLRQQTLSISKPSLHPAKTIAPMRARSNREAVSKGKMSGLSQNSPDYINQKPIVKQESDDETQIPVAEGQEVMKDMDEEDAREDDRRSEEIGCPKPETQKTSEDETTVETIEVDSQMTVPGACVQDLTVKHPGHATKQVVEVGSPIDEKMLLSTPRASTVSCGMESQLARQTSASHQRSLSWDGQDVAVGNSSPPENRKISSLVSCHPQLTSASSSSSPIVKRGVSQSLKPDKAYRDEIVSAAPQGEVTMRFDLSRLRKRFVNAGNHQVGAQNRRVSQRLKQGDLEEAAGIKNRDSELAEETLSRVISKADFEKMEVKGQFNKGFIIARLQSDNGTDDLFIIDQHASDEKYNFETLQQTTKIKAQALIRPRALHLTAGDEIVAMENIDILNANGFDVHVDETKPAGRGERISLLAIPVSKETVFDFKDLEQLLHLLSDDSRPSGQMVRCMKARAMFASRACRKSVMIGKTLTKSQMSQLLRNMGTIDQPWNCPHGRPTMRHLTKLNAAPRSSNIKGRFDWTRWKDALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW91</accession>
    <name>A0ABR3BW91_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615373.1">
        <property type="nucleotide sequence ID" value="XM_066756596.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988903"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0252653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="141" mass="14905" checksum="B77434C363210B0F" modified="2025-10-08" version="1">MSDRRKLAAPVGVGAGKPDHPFAVTVEDPVPNAIVPDGYGIKYHAYHTMSIYFPVFFHFFVWSHADMINVINSTEGVFLPAGTALPGGAVLPMSSVADFPMVLPLGTKLPGGVMVPIVMEKVAKPKPPAAKALPGPICNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWE5</accession>
    <name>A0ABR3BWE5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615433.1">
        <property type="nucleotide sequence ID" value="XM_066756656.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988963"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="9">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="401" mass="43527" checksum="876E8319AB4E66FA" modified="2025-10-08" version="1">MSSLPQKPTENIPPSPSGAGPSKICGICSSPAKYTCPRCSARSCSLNCSQTHKSRDSCSGIRDPVKFVPLNQYSQGVWSSDYTLLEEGRRQVAGWGKGIKIEEVNGGVVSGRGRGRGGSRAPKGQRRSKTDGLRRELEKYGCMAEFMPEGMARKKTNQSSWNPKTEQLYLTVDLIIPSNLILPSPNSTSVTSSNTSSKTITHPRVLFHAPDAEFLPTISSLLPSLTIPLSEIRLCQPFHSTPLRPAPSHQPNQKIFYPPLDADKPLKGVLKGSAWVEFPEIQLMARETWEEMVNKGDVIITEIEAISQVPGRERDSGWGAKRRPNEAAKGEGQQDGAKRLKTESNQGLLALGEYDSEEGSDAENGAEDADALIVEEANDEVPSPEMLVAVGQALMADLGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWJ0</accession>
    <name>A0ABR3BWJ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615473.1">
        <property type="nucleotide sequence ID" value="XM_066756696.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989003"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25111" checksum="61E5FCE8C6AF77E0" modified="2025-10-08" version="1">MQTSTQSEPLEDVEGSHELSMATNHLNVEEELSFYASYHSNKINQLIHFFCIPQILWSWLIVAAHVTLPDAKLFTLSRGLAFQPSLALAFITSYMTYYTLLDPIGGITYIPVGSLLYLTATYLATSPPTWLPLTSPGEPSAIPFALVVHGLAWIAQFIGHGVFEHRAPALLDNLVQALVLAPFFVHLEALFAFFNYKPDLHKKIKARAGLRIRDMNRQKSRKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWJ7</accession>
    <name>A0ABR3BWJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615475.1">
        <property type="nucleotide sequence ID" value="XM_066756698.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989005"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="79"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="269" mass="29513" checksum="795C7A34A6FDECB5" modified="2025-10-08" version="1">MTSTSNIKLFLPSSRPSGPLFIGLNAVRALSIIALLLVFAANIETMVYDIKAIKNPPSDEGDCDYIEYSTVPDQTGGPFWSILNRIFILFECLVLVLSEVGAPRCLFETYIPILGPAYGLGCLGVFQALIGAQVLSHYCDLFPQVSSWLLFIVGCFNILVGILLREEAKKKRLVFSWENLSSLTPQTRMAATAWDMVTEKKGSKSPLESHKPPRVSRQNTRDSESPLLPGTAPGARFGGFGFGRQGEKAAADRGWKINRPVDALPRYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWK5</accession>
    <name>A0ABR3BWK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615493.1">
        <property type="nucleotide sequence ID" value="XM_066756716.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989023"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045673526" description="WSC domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="21554" checksum="96EF9ABD41F821B9" modified="2025-10-08" version="1">MIFVLALFTAVVAVKGLSIPHVRDTPANSTTLAYIGCVADDSVSSLTSGSSATNAEARESCASTCLQRGGSEIAYFNQEAHSCVCANKDQYPSSGEIVYAEDDLGNCRHSDGASVDYIFSPYTLSQCYLTVDSEIAPSSNKTFPSPLTCLNTCTTEYLSIRPAYDNANDQFVYECSCWEDQVQGGQSSDCGFGIQAVYRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWM0</accession>
    <name>A0ABR3BWM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein YchF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615508.1">
        <property type="nucleotide sequence ID" value="XM_066756731.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989038"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="22"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="298"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="383" mass="42150" checksum="30958B6781639DCB" modified="2025-10-08" version="1">MAPKKKVVEEKKIRLGRPGNNLKVGIVGLPNVGKSSFFNTLSQTDLEARIPVPDERFDWLCSVYKPASKVPAFLTCIDIAGLTAGASTGAGLGNAFLSHVRAVDGIFQVVRAFDDAEVIHVEGDVDPLRDMQIISTELRLKDIEWVEKELDRLKKSSKNLGSVSLADKARKEEMATVEKILHTLVDENKDVRKGNWTSKEVEVINGLTLLTAKPITYLVNLSERDFVRKKNKWLPKIKAWIDENNPGDSLIPFSVALEERLVSLSDEEKAAEGEALGLGAKNPSALGKITTSGYASLDLIRYFTCGPDEVRAWTVRKGIKAPQAAGVIHSDFENKFVCGEIMSYDDLKEYGTEAAVKAAGKLRQQGKPYEIVDGDICYWKSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX15</accession>
    <name>A0ABR3BX15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FRA10AC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615658.1">
        <property type="nucleotide sequence ID" value="XM_066756881.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989189"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019129">
        <property type="entry name" value="Folate-sensitive_fs_Fra10Ac1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09725">
        <property type="entry name" value="Fra10Ac1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="36453" checksum="207ED2034FE313EC" modified="2025-10-08" version="1">MSWKSSPGVLASGPPMSSSSNPVINRIKPNPSGLSAFQREALVSPYGASSSIQPKVRTEWDVLKENHRFIRDDEEAKDVSWEERLARAYESKLFKEFALIDLKHFKSKKLALRWRTAPEVVNGIGEETCASFRCKYHEPLQAPSPVSDHAVGFASLHSRAGSTDRDYGWDYPGHDEKERTREKKKPKIMPELKTFELPFVYMEAGERKEALVKVRVCPICTAKLLWKPGQDDMEKDSRGETRSRGKKKEKGDIKGSRKDRDRRIENLDKSAEDGERRRRRKEKESERERSRSQSPRRHSQHHGEERGRSHRHHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX22</accession>
    <name>A0ABR3BX22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615396.1">
        <property type="nucleotide sequence ID" value="XM_066756619.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988926"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="470"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0252676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="725" mass="81121" checksum="7FF6F6424C84D753" modified="2025-10-08" version="1">MSSSAIVPLTKDAVRSRLNSILNSYLQHRPIFQRVFTAAFVIYCLGSTYRSLTGRGSKGVLGGKGNARRAKGGKHGITGSIKDPLFHIRLKRLIRIVIPSLKSREAAMLALHSAFLVGRTGLSLYVADLDGRIVSSLVTANPHVFLMNIARWLLVAIPATYTNSMLEYLQSELALAYRTRLTKHALTMYLDPPELESSGDNDGQQLFYKLANLDDRIKNADQYLAEDIQQLSRKLAEIYSNIAKPVLDVILYNYQLSRNVGAESLVLLTILVQTSATLLRAITPPFGAYTAHEAKLEGELRFTHSRLLESAEEVALYHGEEFEKNVIERGYFALVKHINRILKIRVGHGMAEEGVIKWLWGSLGLCICAIPVFGGSALGMKAGDLGSRTEGFVTNRRLLLSSSDAFGRVMYSYKELAELAGYTSRVSELFETMEHTKKGEYQKKLVSNVSIENNAKILQGRGKIIESDEIKFDQVPLISPNGDVLVKSMSFHVKPGKHLLVIGPNGCGKSSLFRILGGLWPVYGGTVYKPPSNQFTYIPQRPYLCIGTLRDQIIYPHSHADMLSRGKSDEDLSKILEVVDMAGIIEREGGWDAVREWRDTLSGGDKQRIAMARLFYHQPKYAILDECTSAVTLEIEKVMYDHATSLGITLMTVSHRPSLWKFHTMVLEYDGQGGYTFTHLDAEKRLALQEEKQELEHKLLSIPKLKDRLEELKMIKEQRESASVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXB1</accession>
    <name>A0ABR3BXB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spermine/spermidine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614673.1">
        <property type="nucleotide sequence ID" value="XM_066757204.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989520"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="91774" checksum="C2CA3114BFC2E6CF" modified="2025-10-08" version="1">MSQQVTFEALRTKFSPGNLSLQSSPLSTARSEATHAASVTTNSEQDIGLASDLEKQAGRAASEADELDNRDKDSSNESEGPYDHGSNSSTSSFSTDHQFYRSEEAAEAGSGSDSDSNYSSIPSQNSSNIEYAGEAVKRSSQLYGNPSLTVDLSPGTLRISSNEAYRITATETGTQQESTTFIASEEETITLIENPRRLIAAQPKRHRTVQHTMARFSTLYIFPILVAVPLTLLLSLNTILLTPLYNTIPLSLHNVALYALYAAPPTLLYWAVTLERSAKEVVSANFCISIAALNGDLVVVLGRRLGSLTGKLAGPEWGAFLAKAILGIGAVGGGLTFALLCFDHILPISPARSSIGRIRNLANVSARSTAFMLHLWFGQRLLDGSLSGSITFLARSPEKAILFISLYLTTILLFVRSGPSLAVSLNELYGFISHGLGVSPSKPSGLLKYTIFLRPPSERSDPYVTAHGELRVLSSEQSLTGRVVVGDNLKDGYRFLRCDHSILGGRWFREREVNGEKTVELGDSIFAVFNLQEVMTLAHRSDGDESLITTLALTTDLKVTSEGKEDEEPSRGSPSDRALIIGLGAGITAQGFLRRGFNIDVVEIDPVVFTATETYFNLPSSHLTSVNLLDGSAFISELASLSRVNTTDPSLDSKALTALEKLPKWDFVVQDCFTGGSVPGEMFTKEFWEDLGEVVAEDGLIAMNFVGLKKSKASKAVLVTLTSVFPQCRAFGDGFEDNQGPNDITNMVVFCTKTHSPILTFRRPRPSDVHRSPLRSHVFSTFLPNEIQLDSIIFEEDYNDSLMTLRRGHTESLDYWQKETAIATWRAMQKILTPEMWMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXI1</accession>
    <name>A0ABR3BXI1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="12">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PIF1</name>
        <name evidence="15" type="ORF">I308_101962</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="12"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615290.1">
        <property type="nucleotide sequence ID" value="XM_066756513.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988820"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="213"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="12">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="221"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0252570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="669" mass="73589" checksum="FB3A7D30CC686A42" modified="2025-10-08" version="1">MPILTARTPSTSGLNNTSNRTLSRVTSFKRNWGEEDGPESSQLDWSPSPEVIQRKGNILSSSGPLQSTTTSLSLPESAAKETASERRRRAILAALNQNKEAASASAVSDWCPVQKSSTSASPQDIHYGISVAPAASHCPDPSIPHVHQTLQSLPKRPLPWEGDQKARKRVYTQATLTSTGSAQPKSTSSALNIKQRVTLSEEQQKVLTLVVQQQKNVFFTGSAGTGKSVLLREIIHALRNKYAKNPDAVAVTASTGIAACNIGGVTLHSFGGVGLATDAPEVLLRKLKMNKKASGRWTKTKVLIIDEVSMVDGAMFDKFCKLGQLIRKNSKPWGGIQIIVTGDFFQLPPVTKNGGVPKFAFEAEMWDETIHLSVNLTKVFRQKDQRFVDMLNEMRFGRLSNESVIAFKSLARPLKFNDGIEPTALFPRREDVDRANLSRLNQLDTVGFTYHSIDGGSAESNQREKLLSNFMAPKIIELKENAQVMLVKNLDETLVNGSMGKVIGFTYKNMFQCDDLGRWTPDADLKELEEEDKMKSLAVRQALRDKYQAKGANPLPVVRFKVPGGGTRDVLMEMDVFKAELPNGEVQASRSQLPLILAWAMSIHKSQGQTLDRVRVDLGKVFEKGQAYVALSRATSLEGLQVTGFTAEKVMAHRKVTVWSSTLKDLNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYJ9</accession>
    <name>A0ABR3BYJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615620.1">
        <property type="nucleotide sequence ID" value="XM_066756843.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989150"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF94">
        <property type="entry name" value="MDG1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="709" mass="69755" checksum="40528BB6CE6FA018" modified="2025-10-08" version="1">MTQQHLATFTWGAGAQTVCVAGNFNDWSATAAPLKKQPDGSFLAEVSLPWGEKQAFKYVVDGEWKVREDEAKEWDAAGNMNNVYTAPEGPDDKNNVDKSTAAGATGAATSVGAGAAAASAHAKDPATKDATSNPPTTEKATTVPPASTGDTAPASTGGKKTDPEALIAAAAPGAAVGAPILGKPVTGGETDPASGITTSIVIGSAADKTGAAKRDTAKDTLSPGPVPVAVAVPTDKKAGLTEKGTAKDANVPGAIPGSTAASADTAAKADEPINPAVAATTDSTGAVRVTAIDATPQQIEMVAAAANIGEAPTATLGEEHGLAEKAAEYGAAAIATIGSVVGGAAAAVEKATGVDLTHSSPLSIEEARARGIDVAHLQKVDAPTDSTSPQGSAPPASAIAALDEKVAELKSETIGASSTTGVIDQVAVPLPNEQAPKTSYPADGSSALGHTTSSANDKEKDIKNDIPAQPETVDMNHKAVPAPVFTTIAPKDPKKDRSLESTDLKDTAGTKPIDSAPGVDAREAKREEQLHPTAATGEKPEVAEARKAAAPDTPEDNLKLKSEDVGNGSGAGVGSASNGRAQVPQSGVSAKTTSPTTATATITETTQPASAATGTPVTPSKTTAATTNGTSAPAAAAGAGGAAAGAAAVGGVGSTTTGASNTAATSTPTGTKTTSTPGKEPSSQPGSAKKKSGFLSKIKHALSPGHKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ68</accession>
    <name>A0ABR3BZ68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome assembly protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101066</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RSA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615911.1">
        <property type="nucleotide sequence ID" value="XM_066755625.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987924"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051898">
        <property type="entry name" value="Ribosome_Assembly_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028217">
        <property type="entry name" value="Rsa3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127:SF1">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14615">
        <property type="entry name" value="Rsa3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome-assembly protein 3 C-terminal" evidence="9">
        <location>
            <begin position="148"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0253690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="216" mass="23233" checksum="0CAE2E5595021CE6" modified="2025-10-08" version="1">MSPPPLQSQKANRRKRRRRQLSISSSSDDDSNSDDEVATSIVKLASQEAMEVDGKSSSASSSESSSSSSSDSSTSESDSDSDADSDSESSAEITKPVTAPALASQAKQRTRYPTNSPSPPPDSTLPSFFRSSDEGAALDSSSENRDKFRAVYMNKIVEGFGGELEKMRESDPTLGPKRLQLLIDSLASGIDLYTHPKQTKKDDDIDEVTLLIGKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZE8</accession>
    <name>A0ABR3BZE8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615611.1">
        <property type="nucleotide sequence ID" value="XM_066756834.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989141"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="88" mass="10058" checksum="0D2F055E082E5C03" modified="2025-10-08" version="1">MYSSAFLNCFAPPLHWTLDELGEGELADDENMELPDVRRRRKNEANESPKRNGEQRTSTSPSGTSTYYALEGSNSWREMMTDHAIMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZF6</accession>
    <name>A0ABR3BZF6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615989.1">
        <property type="nucleotide sequence ID" value="XM_066755703.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988002"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="240"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="308" mass="34406" checksum="8C893C8EA0747852" modified="2025-10-08" version="1">MMTSIQPLDEKPFVPSATWGAYLYQNFLQSSSDSPFEWSSSVLPTLPQIQTSSSSAGYPFGMSASTSWTASGAGHSPAITKAEIPTPTEDPSLLQQQDAPFYQQPSFYSFPNSAGISTSLLTQSTSSPILSLPSQLNSTESVNLIDHSLTRSPSPLSSHIVSPHASPIRLPTKTRGRKSIASAAVKRSRSLHSDSEFSHHSHDEHDEHDHEHDHEVPEGVERDGMIWGMRVEDYRALSARERKRVRNRISARTFRAKRKEHLSTLEHDLSEKEQQIRVANEENARLRREVIELKKRLSKVEGAYGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZG9</accession>
    <name>A0ABR3BZG9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616005.1">
        <property type="nucleotide sequence ID" value="XM_066755719.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988018"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0253784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15562" checksum="817DE1BE13F5FF0B" modified="2025-10-08" version="1">MATIPARLAKATSSVKSWEEARRASVSAYRTWYRSAPDIVQLYGLHVSPSLVRLKIRQDFERNRDTITDLSVMNVMLLKNHQEYQETMNLWKQEPHVMHWFKKYDNPPQPKTFLEKFYASRDEPSQLEPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZH9</accession>
    <name>A0ABR3BZH9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615641.1">
        <property type="nucleotide sequence ID" value="XM_066756864.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989172"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF5">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="42"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="129"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="182" mass="20039" checksum="7A1658B59041014C" modified="2025-10-08" version="1">MPNFLSCFPSRQSAAATYDPLSSTSNGTSNDADNQKTLASCVFCDVSREKGFNIVYEDQDLIAFHDREPRAVTHLLIIPRSHVASSVRQLTREHLPLLDSMTALAHTLVPSKPTPKLGFHIPPFFSVPHIHLHVFSGPHTFIGKFKYPVTTYAAGKGFGWFVTVEQVKSTLERGGTVGLGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZL3</accession>
    <name>A0ABR3BZL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101138</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615983.1">
        <property type="nucleotide sequence ID" value="XM_066755697.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987996"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="56"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0253762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="497" mass="55109" checksum="93A648B2E21C0259" modified="2025-10-08" version="1">MSTNNHLMATDSIKRDEEWHETSLDNEKDATLELAAQYVPGSEAEKKLLWKIDKRIIPTVWGLYTLSYLDRANIGNAKTGGLEKDFHLTSQQYSIVLLVFFISYVVFEIPSNLFIARVRPSLYLSGLCVLWGGVAACMAATTNWSQLAGVRFALGVIEAGFAPGVAFYLSSWYTRYELASRYSLYYTATAISGAFSGLLAGVITENLNGARGLQGWQWLFIIEGCGSSFLGFFTWYIMPDWPSTTKFLSPEERLLAAQRLAHDGLGNTAGAQGHIGHWQAVKMAVVDWRTWMLTALYMLCTGAQTIQYFVPTLIGALGWKGYLGQYRTIPLYACAFCFILAFCWGADYFKAKPLFITVAATMGTIFFIIVTCVTTHMVQYVFLILAFGCVYALPPLILTWVPNILSHPAEKRGVAIALVNALGNSASIYGVFLWPSTDAPRYIPGFSATTVFMALIAVLAQVMFWLVKKYPIEAPDAERVVQEELAKQRGHGKADIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZN1</accession>
    <name>A0ABR3BZN1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616063.1">
        <property type="nucleotide sequence ID" value="XM_066755777.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988078"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="51697" checksum="BC6D397659A3C078" modified="2025-10-08" version="1">MSKADSQYEIETKFDDIELENPSKITTCTTAAHLEAQTQPNRGRYQSNDKELVAPEPQPTELPLGGESDAPDGGYGWVIIMCVMAMNAGTWGVNTTYGVYSAYYTSNNYFAGGTTLGYAWVGGLSVAVCLLCGPISNYISRKFGFRVALSIGTVCIVLGQCMAGICHSFGTFLVCQGIVFGIGLGMTLVPVQPLVAHWFHRRLALAQGLAASGSGLGGLILSNTTRILLEELSVKWALIINGCISFVLLLPGLLLLRGRHKAIGARQAPLELKWLWHGGFLWVWLWGVFCSKSIMSYFIAIYSLSSFATHGLNLTQTQGAALQSILSAGQMIGRPLWGYFLDAGGRINLAVTCYIICGISTLCIWLPARSFGVLVFYAVVQGMTGGTIWSAATPVVAKIVGVKDLASALSIFWLSLVVPALVGQPIAIALMDYSTNHYGRTGADQYLISIGFCGGLSVLCACLLYGAKVWVQGSWKVFQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZT7</accession>
    <name>A0ABR3BZT7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616124.1">
        <property type="nucleotide sequence ID" value="XM_066755838.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988139"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02661">
        <property type="entry name" value="Peptidase_C19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="147"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="481"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="598"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0253903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="643" mass="71575" checksum="405C25DA1ED732C3" modified="2025-10-08" version="1">MTAASPFLFQSSLHDTGLIHEMLSNPLKFGAPVAKKGSGFEAGMKEVASEPESPELASKQLNNIKDEVKDGKEAELAAKDKSQKQLNGNAENTRRVNTQLTKQSVSPSSPANARISDANEGKNTQGLFPSTFDLSWPETIATAKRAAGLHNPSMACYANATLQILLHTPPVLRIALTHDEGSCLQIKKKNFCMLCSLKHMAEGSHWSGRKAYAPGIHRHLSQIKKGFSKNRQEDTHEFFRFVTDALQNTALARLPKDTPEKIKHASWVYRVWGGRVRSRVVCSRCNNPSDTFDSFLDLSLDVNKQGKKSVLGMLAGFTKEDKLEGDNKYHCEKCKCKANATKSFKIDQAPPVLTLHLKRFSVNYNPYSGRARAEKFNQPIKFEQNLDMAPYMVDPKSPGSRYRLFGVTCHRGTELRFGHYTSYVRGPSGQWFHADDDDVSPVQLEQVLNDKTAYLLSYIRVENGKEGLYESPTVRHRVNSLVNGSAKGMRNDESESQSEAESSSRLSPSPIKRKPTYDPENPPRMKISAFVKNKANASSPKKSESPFSDEENKMAPELPKFGYKPKPTIHAPTPVEASSFYTSPISRPSNPLAGMSKKEKKKFKQKEKGKPRHSATPMPFAQGRVGNGRNRQPGVFSRMKGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZW0</accession>
    <name>A0ABR3BZW0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101294</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616137.1">
        <property type="nucleotide sequence ID" value="XM_066755851.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988152"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040520">
        <property type="entry name" value="Importin_rep_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18806">
        <property type="entry name" value="Importin_rep_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1040" mass="113681" checksum="9AFC20D03066F149" modified="2025-10-08" version="1">MESLTMDEESPTPSLVSFPVLPQSDLAQVAHTILQLFDPATSSNPPQAKYLQSELQKIQGTPEAWGLIAGLANHEDTNVRFFGAHTAQVKISRDWDTLPQELHQGLLSLLLETLSGAMNPQNPSSHQPGNGVVIRKIFGSLASLLLRLEFTIFPHPIRTVIQSMQSAFSQANAQSTGVNLALRLRLLELEWCAICVEEMGRAGLAEHRRAAVRRHVESDLKVVVGTVIRSMNGDNAGSPDERLHEAEAACKCAESWIVWGLGADELNEVLPPLYNLLPLPAACSAVTEVLSESIFKYGKGTKILTEPLISWATGPPGQSILGLTEEDPSDEAVAFAKLVAALVEHSSEWLMAHIQETQVQTFLAMVLRITGWKGIAGVEENISELTLPIYSLLQEALMDSDLFQAPHETHPAWLIAKQFFAELVSVTRRKVRWPGEGEVPPGDTLGGLGKDDREAFSRWRRDAGEVIVGAYYVLREEMMQNLTQTAAQQIQGGASWQNIEATLHCIRYSSEAVPLGEDQSLPVLFGEQVLGPLTQRPIGGLGEDRLRLTVVCLIQSYEEWFKFHPTYLSPCLSYLVPSLTSRSHSVSRSAADALKALCDMCRKKLVEHIGAFSELHGKIGDMGSEEQSKVIQGISSVIQALPPSEAIEPVEAILNPIIDRMQAAVSTSQTNAAEAQSLLIQTINSLTACLKGLSPSDDEIFDAADDEDQKEEEVKRVRGDERMARLRERIYMAIEGVVGVWNGDSEVADALSSLLKHVSPNPPTLISLPPLPLLSLITLACSRSPSALWFTLASTVILSISVPPSFLIKKKDLGAENDEAARAREEQEKWEIVGQCGGRLVEIAQGLFQGEGMRENPDIVEGWFKFCHSFAERYPGVLLRLQSHQVETYIQLGLAGLSLHERFSLKAASDFFVALLSKTRFPSPLEAIFDPLLLAFGPSLLHALVLSAGSEGPRSVIPNLAELLAGLVTRVSSDVMSAWLEGILSIEGFPDARANLESKKKLKAAVLKSRTARRMREALHEFALVARGLEGTTYGNATAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C002</accession>
    <name>A0ABR3C002_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616182.1">
        <property type="nucleotide sequence ID" value="XM_066755896.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988198"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF3">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="386" mass="42246" checksum="00904BA3FC8DA930" modified="2025-10-08" version="1">MTHPSALPHHPPDASLHRSDGESSGSTRNATAVPFANADATSAKRLPAVPNGQHSLRSDSNTPPGEIDNAYEQTSTRRRKAGTRSERPSIQSNTDLKGQRTSSRTACPRKPFEPHLPSAKNVPRAPASAMYFSPVPCYGFPPNQALRAHTGTLVGERIWVLGGVDKQTCFRDVACFDTENFMWSILETQGERFPPLRAHTTTLVGDKLYIFGGGDGPSYSNDVWILDTIFGGGNGQAALNDVWALDVSDPNALTWTEWKTKGDIPQKKGYHTANLIGDKMVVFGGSDGHASFADVHVLNFKTCVWTLINTDIKHNRLSHTSTQVGSYLFVIGGHNGQAYAQDVLLFNLVTLQWELKLPRGLFPSVLVLIYPKLPPSKLMKICTNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C026</accession>
    <name>A0ABR3C026_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase RBX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_101371</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616213.1">
        <property type="nucleotide sequence ID" value="XM_066755927.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988229"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0253992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="108" mass="12451" checksum="8CD5C25D5D9D11FB" modified="2025-10-08" version="1">MEIDQVTNPGKLAAENDKKPRFEVKKWNAVALWAWDIAVDNCAICKSHIMDLCMDCQANQGAESENGCTVAWGICNHAFHFHCISRWLKTRQVCPLDNRQWELQKYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C081</accession>
    <name>A0ABR3C081_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616208.1">
        <property type="nucleotide sequence ID" value="XM_066755922.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988224"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="980"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="793"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1143"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1242"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="794"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="825"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="944"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1151"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1242"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1261"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1280" mass="138732" checksum="43A36F67AE73F9F2" modified="2025-10-08" version="1">MWGSNASAAASESTDSLSLSPSQSATVEPPLPMSASASSTSSQILFDWSVPRLPASHTRMDPFDTFDPVSSSSEDDPIPPESRHAGHQRSVTDPILRDGQPVDIEFTTAGPPIESYEFEQLPTFSRTLSSPLPTKVGSLRHPMPLTADDLNSHDRDLAHRPLPPTPLHFISVELADSLQSAIQTLLHLSPPHLLDNAKEQYSGCSVQIPVTSLSALLTSMRGLNFLSAHAEELVDSGAGGVAPVIHREDFDVGELLQNVADMLSGEAAEKRIDFVLFHGDIGMKHISVYGDSDGISYALSHCDDTIELGLQVIPQSPALTSAVGLPLPSTDVGGETNSNLGSTSRLEPASDRPSLSNFAQDGSLLCVFEIVHNIYQPPPSSASATPKAELNPFTHLAEETESLRPRLDTAFCKNLLRRQNAVLKLDVQPSSPLGSGMPRRAYVLSVLLPRGKPITEPAILSKEEQEVRQPFSSQVLAREPTLDELSQFAESLRGRKVFIHANLSSVFARHLTSYLAAWGMDISHLPTDGDEADKTKILAAKCDSVYTGSTGGPDGTTSSSEAPYSNIPTDMPAVHSGHFVIVDDDVAVLRHELFRIRSELLSISFKPRISKRPTMISRTRSSPAVRQIPPRSPGAVLIHFTSLANYNRVRDAITNFVGAPLLTNSETYVQPEVMVIPKPVGPRRFLTALYTAVKQPMVDPFFTPIATSPRSPGAGYFGGLRTPTERESGFFDSVAEEPHEELDPRSNPTIVQKAKSPLREFPPAAQIVRTNQGLHLSLPTPNEIMTTPAQEYFSGASRSPGSGASGVVMQSPDGRPFGMFFEPPIKNERRGSTHRTPSDSIRRKQANRRASASDEPIPSPSAAPPRRSSTISTAGREEHRSSSTTNVTDRPTHSRVNSRRKNNLPTAEEPIMAVGRAKGRERSETVTKGGDSASRKGTPVASPRTEENKELEKGEKAVMPKSLVPAKKNAKVDVVVPPINVLIVEDNPINQNILSMFLRKKKIKNSSAKDGAEAVEKWRTGGFHLILMDIQLPVMDGIAATKEIRRLERHNNIGVFPSTPAAELPRGPNIADPPTPSSPFRSSVIIVALTASSLQSDRVAALAAGCNDFLTKPVSLKWLDKKIVEWGCMQALIDFDGWRRWKSSDTKNPSETKQGFSVGPQQAARSLASRLRIERKGSRSPAVPASTPRLNVQSATPDRQETPAEPASQVPMTLPVAASDPPLSPKSLNKTVNDVFKQADARLENARVEQEISSRNEHTSLPDSTNTTITPSKTYPAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0C0</accession>
    <name>A0ABR3C0C0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616302.1">
        <property type="nucleotide sequence ID" value="XM_066756016.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988318"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="93"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0254081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="525" mass="57347" checksum="A21E93FD0DB95DE0" modified="2025-10-08" version="1">MSASTIEILPPIQGKELSTDFVPSTLSGHSSSTAGREPKHSRLGAILSRDSRQHDSDRQQIRKFDFGFLPIPPNRRHHPTERVGDESEFTWRLNLLFACAATVSVMNLYYIQPMLVAVADSFEVSHDAVSRIPILAQGGYGCGILFISPLGDLVRRRQLVLLLMFFTTCLSIGLALSRNVNMLSGLSFVVGFFTITPQIVIPWTADLAPLKRRATAMSVTLSGLIVGLVVGRTLSGIISLASWRYSYWMAIGLQGLMLIILWLCLPDTPGKKIGLTYPQVLWSMAKMYTKYPTLVQACFQSYTTSAVFAGLWTTLTFLLSDSPYHYSTLEIGLFGLLGLVGALLSPIWGHLIDQFHPYLAQLVGIWICMISMIIGLTAAKINVGAVCVAIAFYDVGQQLNQLGNGYRVAGIDPNARARLNGCNLLALFAGQTSGTAIMTKIYNSRGWQPTAGTAIAFLGVGILTLLVRGPHEIGWIGWSGGWKVLKKEKTNDTSANAITEKLKSKKKKGHSLKPVEGLIEGEKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0D3</accession>
    <name>A0ABR3C0D3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616320.1">
        <property type="nucleotide sequence ID" value="XM_066756034.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988336"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0254099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="293" mass="31950" checksum="3D9E15D08634DF65" modified="2025-10-08" version="1">MPQTAPQQLPAPTTEALAFSASLFASSIASWIPPNFGITKSETEKQADFEIALKEDRGGRLGLGHPLIDAPRKYGDARGGNGLAGLSKKLGNEKKNKDKEDGGSLPPQQPQDEDEEESRVKSVGKGKKSVNGVLDMFGGKKKRKTEQQVHPLAQQQQQQTAPTPIPHASEDGEEQEEPPFPNPQSPLVPPEPPTPPPASSPGGSGIFPFQGPLALESPIAKKMMEERITRKRRAEEVDQEEEEELSSKERSQSLLGSQTSTPIKKQHQGPKSKTQIRREARKRAKLAQSQRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0E7</accession>
    <name>A0ABR3C0E7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616082.1">
        <property type="nucleotide sequence ID" value="XM_066755796.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988097"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="498" mass="53939" checksum="85323AA3ECF8F94E" modified="2025-10-08" version="1">MDDPWADAPASPLPKTEQRFDNVKNVSDNEDANAFNNHFLPKSPPANGLDEAQEGQIEEEAEVTTEAEPSRKEINGASEDEEVEEPAVQSSPAHESHQWLSPQAQVSDQVAKVGREENEEENEKEENGEEEQEDFDDFNDFGEPGSSSFPAANPNLGEGETPGEGGDYDDGFGDFADFDEGEFDEPVDAEAGIGGNGLVEEPEPIKERWHALELRPPPPKSEITAQLSSLLSPLFLHQDSLSNEAVREVRGLAQVLVSQSSRDAYAQLTTPPITKPLDWTRSRVRREHLISMGVPVNLDEVDSHRLSALPPLRIVTSASGSSRPQPRRAETFDGYQGVKYMSGQKGKGRDTDWPASAGPAVGVGYVERGVNGGGIGKYGLGQKPEIDMPRAEELCGLEEDALSLLSIISLRKLQADLVENTSQVSATLAWMLQLKDAQLHDSATYNGMISSLIANAARVKASQNTGGGSVFRRGSSKRPQSVSGGMTPKRTGSPNVWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0H1</accession>
    <name>A0ABR3C0H1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616350.1">
        <property type="nucleotide sequence ID" value="XM_066756064.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988367"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0254129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="213" mass="23362" checksum="9DB2CF9990FE76E7" modified="2025-10-08" version="1">MSDQNDQASTFTPIHPFNMEQPKTWSSTIGMLNWDNDKIVFSKRSLLEFLKSAGVTVNQNFSEIQKLPKYATFGKFSQAATDAAVADLVEAEIADPTTESSIPPSKSTVPRNGKENNVRLFGEEYEEQDALSLAPPRDGGDGVDVEVERSERMKMHVEPEQEGGAKIEDVKDDDKEKKDRVSNPPPGFKPTRKVTQAPGGKSSVGSILFGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0M1</accession>
    <name>A0ABR3C0M1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616393.1">
        <property type="nucleotide sequence ID" value="XM_066756107.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988410"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="273"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="293"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="329"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="365"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="470"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="506"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="647"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0254172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="673" mass="74830" checksum="E9D6254A98BB41D7" modified="2025-10-08" version="1">MATQVTDYDGNDVASQMSSLNITENHYASIQQPQPPSHSQSPVTSTYPNVSTPPARGLAYSAYTGEQQGYPYYSASAGVDQFGGQMGPPVTYPYGAPVELLSHSAPMTFVGRSGGGEVYGNQQDHSQGHQQQQGLQANGTPGRQSYRPSHAQALQQSAQYFGYSDQRQYWMPHQQIFVQKNESKKEYQARSAQGPMNRISQNSGSNFHQDFNPALRGNFHGQNNLSLHAIQTGQYGLHPAPHFVALTGFPPQFPSQYLGRLSSARKSDDTGVIRSALLEDFRLNKLKKWELNDIFGHIVEFAGDQHGSRFIQQKLEIATPEDRQKLFDEIYPDAYQLMTDVFGNYVTQKMFEHGDQLQKAALAKKMDGRVLQLSMQMYGCRVVQKALDHLLNEQRAKIIAELEPHILECVKSSNANHVVQRVINIGPPQSIPDSFIGHVEELPKHPYGCRVLQKTFENLDDKMKRSLLDEMHECVIPLTEDQFGNYVIQSVITVGEPEDRNKIINQLKGRITTLARHKFASNVVEKALIHADPADRRILINELIDMQPDGTNQVGMLLRDAYANFPLQTGMFAAEPTQREELLEIVLPLLPPLRHTPVGKRIEGRLAQMEDEGGISSVMMCKTLSSSTATTDTNAALSMSRTASSSTVLTSPELSAIHTPTIKSPEKDNTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1Y0</accession>
    <name>A0ABR3C1Y0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cellulase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615775.1">
        <property type="nucleotide sequence ID" value="XM_066755489.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987785"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00551">
        <property type="entry name" value="AmyAc_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046263075" description="Cellulase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="7">
        <location>
            <begin position="35"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="526"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="813"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="827"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0253554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="878" mass="94372" checksum="E61387C014160603" modified="2025-10-08" version="1">MSAFTYTAALFSLISLLPSALAGPTAGTTYSISPNQHPSMCLAPAHTWEGADVVIKDCDEDDTTWLWTGQSFQNTATQLCIDIRDAGAWSGNKAQVWGCFPYNTNQQFNVEGSMIHWEDFCWDLTDGSSSAGTKLQIWSCFSYNDNQQWTFTEIEEVGCDATSVTETATIMSTATASNSDLSSATASASASNIPEAVSAAESLTASLNSSDPFFTASATGSGYEANATASATESAYESLNGTASATYSSYNVNATASATYSSYDVNATASATDSGYESINATASATESGYEFVNATASATLSASGTLSAETSTATNSSIGEGLWSPHKSSSVSSDEWSSETAIDSSTEWWATSTGSNSWASATASASNPWQSASESGAWNSTSTASNSWETASQSDPWNATSTASNTWETASSSQAWNETSTDSWGASATATATTSDSYGSATSTSTSAISATATVGTISSGYLQTSGTKIVDSDGNEVILRGTNIGGWLVLEDWMCGISDESGSADRFSLTTLENRFGTEQARTLVEAWAENWLTTADFDELANIGFNVIRLPFSFRTVQNADGSWRDDAFTRMDWAIAQAKARGIYVIVDFHMWPGQEADYSAISENTDEGQSQRNAVGEIWKKVATHYLGESSICAFDVINEPTGSYGDYLQQDLYNAVRSVDASRIIIHESISTNPSTYGWTNVIYSLHEYDMMGSDFDSNKATWANGVQAYIDLWHGYNIPFMLAEFMADGDTLDYMLNSLNSQGLSWLTWAHSTVNMGRWGIWNHQPFYVDVSSDSYDTIYNTWTNMPSTFHTYIYDQLKNAATGSTSVSRKRDLAPGARTTKRLHGSHGGRSRRNGVAHAVKGAAAVSIYAKGSRFLFPSSLREHFSSFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3U2</accession>
    <name>A0ABR3C3U2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maltose/galactoside acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616573.1">
        <property type="nucleotide sequence ID" value="XM_066754672.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986951"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF23">
        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="211" mass="22877" checksum="85D7E7BEA3B37464" modified="2025-10-08" version="1">MSTAPHLTNKLIPPPEEGEDPTQLSLMISAKPYLAGDKYLDRLRNRGAITLDEITRTPDHAERMGLWKKFANVGEGVSITQRFFCEYGFNLHLAGENFVGANCTFVDVCPIYIGKRTMIGPDVKIYTPDHPISPEARSGLAGEEWGKTVRIEEDCWICGSAIILPGVTIGKGSTVAAGAVVTKSVPPRSLVMGNPARVVKKILEDGTIVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4D9</accession>
    <name>A0ABR3C4D9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Outer spore wall protein RRT8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616749.1">
        <property type="nucleotide sequence ID" value="XM_066754848.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987134"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34175" checksum="4CE0114480C1A918" modified="2025-10-08" version="1">MSSSQTRKRSQPLKLTSETVTESARRQVQEVGAIAQDGLSSGAWIYPLLGILYLFSHPTLIRPLLPVIIKGILMSAGVVTALFAFAYLPQVAVLAVISGPLAFALAIPLILGEAFVVVMFLTRGILVAQATVDIFDAVLLQKGHSALVENGRQVTDKGGKVKQLGTLMTKPLSRFNVDSVVRYLLTLPLNFIPLVGTVFFLGYNGYKAGPGFHARYFQLKDFDKDRRQAFIKKRRGAYLMFGTMAMALNLIPIVSIVFSFTTATGAALWASELENMGKTTTAVPQTDANNATGKQEEVEVQLPQPAVNDKKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4U6</accession>
    <name>A0ABR3C4U6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616934.1">
        <property type="nucleotide sequence ID" value="XM_066755033.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987321"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="172" mass="18751" checksum="01A108C48B1E3C4D" modified="2025-10-08" version="1">MLENGQSGSFPIVQNASDQRGGGTKNSKVPHYSHDASERRESDGTYIRSPPARKKGFFKKLFGCTCFEFDEGSDPVARYRPRYDTVRTRSPPESVPPYSREDPHPPSRPFPAAHRSITSFDSTTSFPPQDQSHLLFLPAKRPPEDETQKTYTPPNGSFAGGTTGGAGAGGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C523</accession>
    <name>A0ABR3C523_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_100526</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616996.1">
        <property type="nucleotide sequence ID" value="XM_066755095.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987384"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0255719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="305" mass="32924" checksum="F94548EE0AA1A352" modified="2025-10-08" version="1">MEADPLYHVKQLFYQASYQACISEASEYPHTPSDDPSSLHRALYIARSHLALSSPSPSSAHDVLAPFLSLSPVPLSARAVDAFASFHEAEEDARVEKVEEIRDLVLECEDGSDEEEKTVRAIAATVFILVGENEEAVATLTEGSAKDDLECIAILVQLLLSLNRRDLAQATYNSAKKFGSDSMLIQAMEAWIGLKTGSQPLHQSYYFYEELYQLPNGRTAPVLASHAAAHLLLGHVDEAKADIAEASQSKAAQSSSDVLAVGASVGAEGFAEKLVTAAKQHPYALDLLEKDKLFDEAAAKYAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C546</accession>
    <name>A0ABR3C546_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Agmatinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617014.1">
        <property type="nucleotide sequence ID" value="XM_066755113.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987402"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046302575" description="Agmatinase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43299" checksum="963A5C204B5624A8" modified="2025-10-08" version="1">MYNRFGVSILLMTAASVVLAKSQEGGGYSQQLDPWNDEFANTPDLSFSGVASFAHLPHKRCLDVKDAAFDIALLGVPFDSAVSFRPGARFGPYALRSGSRRQRPDRGYSSRLDVNPYSGDLSILDCGDVPVTPFDPATAIKQINSAYRSLLHHPVVSPEKMQTLNMQRGLDGNMHPRIISLGGDHTIVLPILDAVHEVYGPVSVIHFDAHVDTWNPHRYVGSVSVQADVNHGTFFWHAYEKGFIKPNSSIHAGIRTRFGGPQDLEDDVTAGFDLIHTFDLDDFGVDWISEKIKTRIGGGPVVISLDVDVMDPAFVPATGTPESGGWTSRELRRILHSLCGLNIVALDIVELSPAYDTNAEISAIAAADLVYDFLSILALGVEDRKDAVSGTSALKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5F7</accession>
    <name>A0ABR3C5F7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616682.1">
        <property type="nucleotide sequence ID" value="XM_066754781.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987067"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1125" mass="124020" checksum="B3A725DAB9FDA4EA" modified="2025-10-08" version="1">MPRPKPQIGPGKWIDTRRPDQSSATKPPSQRPLIPLSSHGLPTPPTTALRKRGEPSTPSIGGFGKEKRTPMSHKQSSLSRFIKGKNRAVELRTNENQSPLPLGGNRTVLGRKSKLEIFDDNYRGDGTRSNDTPQSREPPSTRRTVEERDENLLTSRIGRFSSKVIAQSRSEGRTRSRSRSPMKPPRQAICSPSRKRTPSPSKYPSLFPPHTPVVLVSHDGLPQSGSMYPPTPVPEIDMERHRRLAGQDESSKRKVESPWKYDFPDQYSGDNKRKRDDSPSESEKIRRSAQEVFKEYKRDKDRPRDTSSDENALPKPPPKKQKIHSTPSVQAKVFRRDPVGKAGPPIPTALPHNVLRSYSPLPRTSVLKSSSPDMTPETVSGRTSPGSSPNQRPKNSSSQMIPPSSPAAAMVPSSPSQQGKGQPQVTMTVSNQSSSHPPMSRHSDPWTSHEETLLIVPTKARAPDRSISSPLNESQGWFNPVFDEPRSTSNANEVERGEVVHNGENARYVGHVGAENEVDPELENTQGFTFRIASPSKTATMSLGSTPVRRSQRIASQRTASPSPRIPSRACATPIKSPKQSSEMKTPSNRRLSQKTIGRSGKRSPGLSFRSQYEADDDISSSHPELADTLLPGMFSAGPDQTIPDPQSSKTHSPSQPLRLGQTPAKNMSPLRSQKPFTSPQISSSRSQKHFSSTQMSPSRSRNHPTSSPIFDETGCSGLEETVYFRAFNIPSPPPHRLTDMPPPSPSFRRRPSQHHATQRTSSQVPTVAPNQPSVEEVTRPGPSPIQKSSSTVPKGQGKRKLRGDIPSNKSGEVLVSGSDSFRASQLKFSGSKEEKDVKEGMGDEEGDKKRMKVQDSEGWNETDNEEEENEDEPVKATPWTRAAATSSTPNNSISTARKAKGKATAKKAKTLGKKTPIQAQEKAASLEAFGFFRKRKQKQKRFEFGTSFDEELDVESDQSDEEVRESQATTAAKSVTSPHKTLAKVPSPPPHPSLRPAGLRELRRRKTEEASQAVERTQWAPVDTQSSSQTTATFPLSLPPSSFPDTQDRAAADEEIEGEERPLFEEYIRLQERPSSSQILASERTGEAFSSQSTSMSLKTPASTRAYMRELREGRAGLPMSDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6R9</accession>
    <name>A0ABR3C6R9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_100275</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616748.1">
        <property type="nucleotide sequence ID" value="XM_066754847.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987133"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="223"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="534"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="722"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0255471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1188" mass="132521" checksum="29058DD53BE07E57" modified="2025-10-08" version="1">MSTDKELYKLELLSLVSKVSQELFNHTKLQDKKLAEFVIALHEQSKTTEAFQKKLNEIGADFPEWFIKNLDRLIVTMHPKYKRKAAKMKATGQSRKSGDGQSIMDEQKQLQARKFPGLSMPDQEWGPGEKYVDEGAAKEVHETLPESLSTNDTMAQLESIASRRNRPAAEDYLDGEPVAKKMRSTISSGHDGSSGRRGEYEPGGFRDSSRHGRPTFDERPVLYKIYNGTIANITDFGAFVTLDGVERRVNGNQRSNEGLVHVSNISNGRVNSPRDFLKRGQRVKVKVMTVSPKIGLSMKDVDQNTGYDLSPHLTVQTAEEAAVQQQRMSSYAASGSNSTPLLAVDERQRSSAKRLSSPERFEIKQLIASGAVSAADYPDLDEDFSTNVANHEIEEDIDVEVNEVEPAFLSGQTKVTLELSPVKIIKAPDGSLNRAALAGASLANERRDLKRLEANEQADAETREINQPWLDPMANQNERQFASDIKGNLLGQKAAQMPAWKAANKVVSYGKITSMSIQEQRRSLPIYKLREQLVAAIRDNQILVVVGDTGSGKTTQMAQYLAEEGFLEKGRLGCTQPRKVAAVSVAKRVAEEVGCRLGAEVGYTIRFEDMTSPETKIKYMTDGMLLRELLIDPDCSKYSVIMLDEAHERTIATDVLFGLLKKACKRRPDLKLICTSATLDAAKFATYFWGCPIFTIPGRTYPVETLYTKEPEPDYLEASLITILQIHLMEPAGDILLFLTGQEEIDTACEVLYERVKALGPQVPELLILPVYAALPSEMQSRIFEPAPPGARKVVIATNIAETSITIDGIYYVIDPGFAKQNAYDPKLGMDSLIVTPISQAQARQRAGRAGRTGPGKCYRLYTEVAYRNEMLSNPIPEIQRTNLASTILTLKAMGINDLIGFDFMDPPPAATMLTALEQLYALGALDDEGLLTRIGRKMADFPLDPPLSKMLIKSVDYGCSEEALTIVAMLQAGGQVYYRPKDKQTQADAKKAKFHQPEGDLLTLLAVYNGWKNSKFSNPWCFENFIQTRAMKTAQDVRKQLIGIMDRYKHDLVSCGTNYNRVRMAICSGFFRNAAKKDPTEGYKTLVEGTPVSIHPSSALFQRPPEWCVYYELVLTAKEYMHQVTVIEPKWLSEVAPTFFRIADQNKISKRKASEKIEPLFDRFAADKDDWRLSKQKKAARSSQTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C7R3</accession>
    <name>A0ABR3C7R3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617063.1">
        <property type="nucleotide sequence ID" value="XM_066755162.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987451"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="717" mass="79216" checksum="3CA43653DD966071" modified="2025-10-08" version="1">MFIIFCPSYHRSSPPPLSFFSFSSLAATLRCKSILELLHHIHLFDFGLPTPNFARAVCLASPARYTLYLLLQAASRLWAFDLPPRFSPLALYTVLYILQIICLSPSVPAAIAYQVPAVIAYVFCDQTVHRLLSRILRPSQTPPASTSRLISTSSTRNNSTIYSKEEHSICQEESFTHIALIDRCKKLKPLSSELNIHTPSFDRAPVVPDLHFLSFSATSLQRHPGSGNLSIQQGEAGLALVNILMMSEACVLPTHLPPSSPDPTHLRLLAFSVAEAALQSDPNSPSFSLTTDKAPILPEFSRRLCNWPIRVEGVEEDWKKNRWRGTEYVNRAQWKMGHKKMGMKKSSLGKIVSESPSISPSSYNLNLPRNSSLAAITSDYDWNDPYERPAIASEKQTKGIRRQRLWSCTRFVSPSSTSPQLDQARPPPDFELSLAAKKCTTRPEHGPDNNNAIAKSDVFLPNQPIDYPPCTNLANKTPTDEYTSSRIEARLALSTVLSRRPSTPPSPIAMSIASSPKEKEAPRLAPFLRERTNGRISRRPSSMPPMTSPAEHMTLLAALEKNNYTPPKPAVMVTPPKNRYKFEGRGDVPEPIRPPLIQSLSGNTKTSGIGGSSFQHMTSTPSSDWTAASPTYITSPTGSASSTMSIPRIICTPAPVKIVKDGLEMDSDEEGDVVLFEADTCGSEPGRPSFLQATQEKERVARAAAMKKRLLQRRMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHW5</accession>
    <name>A0ABR3BHW5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610808.1">
        <property type="nucleotide sequence ID" value="XM_066760983.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993414"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="56"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="556" mass="61202" checksum="B13A186271AFCBF1" modified="2025-10-08" version="1">METEAPKIYEMEDYDPKAAGSVDQTEIHISETEEGDIMRAKVLDSVNHRKLNARQIQLSSIAGAIGAALFVAIGSGVTAGPVALLIGFIFWATVVYSVAQCQLEIVSLFPLDGSFIRLAGRMVDPALGTMVGYNHFFAQTSFVIFEATVINTLVSYWGYSESPAILISVSLLLYLAINVYRADLFGEAEFWLALGKVLLAIGLILYTFITMVGGNPLKDRFGFRYWKDPGPWAGDSPSTRLESFINAVNTAGFCMGGPEYISMIAGEASDPRKTVPRAFKTIMARLVVFFIGGALCVGILVPYNDPTLVTGDGTYAGGSPYVISMNRLKIPVLPSIVTAALLTCIVSGGNAYTFNASRSLHALALDGKAPAALRRLNKKGVPYLAVIVVMLLSCLAYLALGSTSAKVLNWILNFCTAATMLNWCVMAFTYVRFYSAMKAQNIDRKEFLPVYSKLQPFAGYWALFWACLFIWLQGYSVFLKGNWNVATFIFNYGIIALAGAIGLFFKIYQRTPFHRSENVDLYSDLDFFDALDQHYQQKKDDLPPATVKDKIMTKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHY1</accession>
    <name>A0ABR3BHY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Caffeine-induced death protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610823.1">
        <property type="nucleotide sequence ID" value="XM_066760998.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993429"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21439" checksum="2C8D3302339D6200" modified="2025-10-08" version="1">MPAPPFGTASAYTDSFPAPPPKQVTVTAETCFNLGVFRDIVRQYRKLDDQIIIRLNRAQAELRDRARTSNEGSWISGGVKSMEGAEGMCVKMWSEMMAGWAHRQTLLTFCSQTVQSSVEGKRNEGAHVRGIREEEVLADQLASEESIEAIIRKRTLEAFKSRCPFFMPSDNTSKAWYNLADRGLKGHGPDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIE8</accession>
    <name>A0ABR3BIE8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipoyl-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610971.1">
        <property type="nucleotide sequence ID" value="XM_066760699.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993121"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="PxpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698:SF2">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="160"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="237" mass="26141" checksum="2DF63650E76D09D0" modified="2025-10-08" version="1">MHQLDPRHRLVAQKYNPSRTRTPEGAVGLAGVIGAIYPIESAGGYQLLGRTLTPWDAWAEKKCLLDNFDQIEFYPVSEDEFVELERSYKAGSLKPESSKGTFKISKYLKFMASHEKEVEEFKKKQKEASEILTEKEEALFAQYAAENEKLAAAGYHKAEGVEEGVPIASPLPASVYKILINVGDTIKSDEQNLVELEAMKTSVLVPAGEGMSGKRVAGVRVVEGDFVNPGDALVYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIT7</accession>
    <name>A0ABR3BIT7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611097.1">
        <property type="nucleotide sequence ID" value="XM_066760825.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993251"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="99"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="191" mass="20529" checksum="2DEE93BA7111EC1C" modified="2025-10-08" version="1">MPHADSSYIPDTIASKAEFYDHVVSHLEALLEGERYWVTNLSQASAILYHSFLACSLYGGNAHSPVVNWCGFYLHPPAHPSSSSSSSSLLLGPYHGRPACLSITPTPGKGVCADAFVNQATLIVPDVETYPGHIACDGDTKSEIVVPLRNRGGKVIGVLDLDSTQVATYDEEDKKGLERVADILAKGCDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIV9</accession>
    <name>A0ABR3BIV9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Scavenger mRNA-decapping enzyme DcpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611122.1">
        <property type="nucleotide sequence ID" value="XM_066760850.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993276"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="39918" checksum="2C2674795F137696" modified="2025-10-08" version="1">MPSESPAPLKITPALLAGFEPERILSESTMTGSTFIFGTLAGQQAIIHVQKTVVVGKDAEDALKLLENVKLLLENAPYYSAHAWTKADPSNPDHVVKIICPATADHIKKYSIQERYVVRETAEVYEQAVKPYIEEMPISKIGWVYEILEGRKEAERVYYRSEGDDGFVILPDLKWDETTENALYLTCLVQDRSIKSLRDLKPSHIPLLKNIREKAAAEASRRFGVDAGKLRLFVHYHPTYYHFHVHIVHIRHDNLFGQVAGQAHLLDDLISLLELSPADGPSLLARKSFTYTLGVEHRLFLLMLKAGAVLGSPITITDAEAKAETISATPVNPAVSTPSLGAIEPATDLEEPEAKRPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ10</accession>
    <name>A0ABR3BJ10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610750.1">
        <property type="nucleotide sequence ID" value="XM_066761210.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993645"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="747"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="839"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="920" mass="100634" checksum="25C92CC0872BB6E5" modified="2025-10-08" version="1">MLPLLSIKWGQPILIDVPLFNQVVEFQASKNLHKGAQSIIARRLLETIIPPLVEHMVDPASEPFPAEFDIYHSLEHILLRFNQHQPFDIAVYIFNPPTPTSMSTMPDNQPPYSVPHYPSYTPPPPPRPNSTVYPPTYDYQAAPVPPPRPSTAYSAPYASDVSHGQSSSSSWSHPQQFSTRLEAPPMSSARQFAAPQSATFSQSSQPVGRHGASSYSQQDEYWTSNYSAGPPASLLGEHIVPGSVIPSTTPTPGPSNSTRPRTSNFDSRPFPTVGIQPTTSNNFPNSEAGFLVVAPPRSSSLNQPYLGHTEAPNLPTPTLPTPKLTTPTDFIKVHPFPTVESLTQASAKLDSWADEHQIAWAQDVLRLVERHWLQNSNADHFEQPSSPPSVTQHLSVTLQHLLDTAAPIIIVISDSDIEAHASLALYLKGKLLSSGACPAVLPKDKRRSFEDFEKAARMGEKRAWHRLGKDYEGVNDLARAGDCYDRGARTGDCESSFIQRMGMAYLLGQLKFFPDPATGLYFLHQSSNTATIDFPQASYVYGMLLASDITLQTNIPPNLIIPPTSPPTDAFLAQQNLARESIERAAYLNYPAAQFKLGQMYEHADLSCVYNPTASVAWYMFASQNGHLEADMALSKWFLCGAEGHFPKNEGNAKMYAEKAARKGHPNAPFALGYYNEIGVGTDVDLEQARKWYEKAAKAGNAEAPARLAALSLPVPTAISMNEHQSRLNDTLVRKRTTAKLRSDRNCFSRPLRQQNYQSHPTPLPDHGQTNSQSEFGQMNQKQMPTAFTSPPPVAHTQFPPSSLSPATDYLPHHPDLLTPSKILLANPPDHLCISTNIPPPPPLPPPARLNASGSSVSDLPVPSASSYTSVSISSSDPVGTVNGGVFGVIEKKEKEKGPQTFAEMGFVSKPVEEDGCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJB4</accession>
    <name>A0ABR3BJB4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611267.1">
        <property type="nucleotide sequence ID" value="XM_066760506.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992914"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="238"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="238"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0241885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="837" mass="91187" checksum="71DA8D4986B06AF1" modified="2025-10-08" version="1">MSHPLTPPPIPFVSIPISSSGHTPPYNSDEDKFHEKCGANNSIPMAFNIPDHTMVTNQSSFTYKHVVSQPSTGYTFPITVPLMSSQSKAQHATNFSFSPPDSIRSKRDHTLESSFQPSSFTSSSEWQNTDSECRFGMDTEIEASSMTDSGHLSSSSLLSSQDKNKSQVTVPRPPNAWILYRSDMLKRISEGEKVPGIDKAREELDLSLSHGDSLGDEGSENRAMPPPPVKKIKVRKGAKMPTEDYIALGPGKGGKGLPQSDISKVISHLWKNEVSEIRTVYENRANAKKLEHQKLYPDYKFKPKRKAEKLKQRKEREREKQEARRLREEEKQAGKAKRRSRNRERRSPVSSRHTPSFGRTLAYDSESSGFYPSSFETSNMPDLPATAAQATFKRPFPLPNYAVPALPGIEGSPSSTSGQAVAHDHTWGHTRHTDPLMMTTLDLIAPPMIEQYSSDSLSTPSQHLTAPASPGQLLSFDTASYEANFPAIAGSSPESSVSDEGFQKAMLSITSAAHNVSGRPMAVLDIDDISVLGDDLCHAHEDPAALAQAWWELDKHSFENDTWSPPSTSGLIADGRTSSITALEAGTSQDLSSNIISISIDEGSPQRETLDATDHDTEASQLPLMIEGVAYQNFPTIYQQPIYYTAVFDSNSDFLGMTPVFEPTLFGQAPSSFDQGPFLSTAQPLSPTETYSAGPTPRESTFLQAGQDFNRMSFSPTVEGTDRTLSAANIAPHHVSSSAYPLTPLSMDTMSLPSVTGIVDRNTSFSALTAVLAGHGMGMMGEDMLAWDEDEFAAENAAANASVVVNGSRKRRESVSMVNLEPIAQAKTPTSPVGLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJD3</accession>
    <name>A0ABR3BJD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SWI5-dependent HO expression protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611286.1">
        <property type="nucleotide sequence ID" value="XM_066760525.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992933"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0241904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="62174" checksum="017ADCD0DF90A80D" modified="2025-10-08" version="1">MAQNPSKIPLPASKTIPKSLSDLSLSDLQSPSKASSAHDRTSPITPIGVGGRRLSLINGHGSGYPHNKLTNSVTGRTSRTSKRTSISENIAAHSDDPVILRTQILSLKAALESAKKKLSEVENTRSDSPVLPDIPSVTPLKVSLIGESRENGQTSPLDYEPHISGSRPSSRGLPYSKGSYDLKCRASIPKSDGRSRIPQAVISQATALHPTPPISSPSRSSAPSPSRSPTPNPDSSLHSPFFPPSSPQSFGEWSSSSPQSLSHEGYNPSPRSVQSARNASTRVIDSLQTELLSVKSHLERVKTEVRAGQRRVEQLTRQKEDLRETKERMRVENGSLNNVIARKERLLQEVLERARTAETSLKELQQTRKSLEQSTKKQVQEMTQQMDDARVEKTKAERECVSLRDGVKSLRDVWAREVKALKEELRRKEEEDKREMEEARNKYTALKELIEAQSVERVSTQELINKALSNYTTLHDHFETETSSLRARAKELEDVVDKQAKENVSALQQVGKLAGELQRLRRLMREMSNEELDKAMAAGNEVNDKSVEKDKEDLQNDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJR0</accession>
    <name>A0ABR3BJR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106198</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611406.1">
        <property type="nucleotide sequence ID" value="XM_066760645.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993053"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="9">
        <location>
            <begin position="30"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="10">
        <location>
            <begin position="214"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="415"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0242024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1062" mass="119045" checksum="9F8FEDDD4CF58C85" modified="2025-10-08" version="1">MSSTTDPGAAVSSFVASYESTLTQVSVRAVGSQFALMAGISMATLLAFSFFRPREKKVYAPKIKYQLPKPVDPIEDPDYEPPPPPISNGFFAWLSPMIRLKEEEIIANIGLDAATFLRFLRMLRNIFTITSIIVVALLVIDIIYNLKYVNSSDRNALSLLTIQNVSGNWMWPALAASYVINFVAMYFIWLNWKSMVRLRKGWFRSPAYQTKIYSRTLMVTHVRKDFRSDAGLLSLMGLLKVDGIKIGPSIDCTCIGRRLEDFPKMVDDHNKAIQELEKHLVKYLKGGEMAKKRPVIRKGGFLGLFGGVKKDAIDYHAKEIKFLRDRIDAKRHAIDSLLRKERHARKKGNKMVNRVEGENYGFVTFKTIAEAHRIARAHRGKLKELFGAELQLAPMPHDIVWENISKEPAELGSKNTFGFVIIGIVCFFNTLPLLVVSLLANLSSLTVYVTFLADWKDAGSWGKWTFSMVSGILPSVVSALFGFLLPIIIRKISKYQGAPTRSRLDRAVTARYFFFMIISNLVIFSLLGVVYTAVARIVVQIGGHQSVATIFKGFEDIPDQIQGTYVQQSTYWLTWLPLRGFLVIFELIQLIKLAMVSIRRFMFSHTPRDIREMTKPPYFEYAIVVVNLLFITAVGLIYAPLAPLVAMGACCVFWFSSVVYKYQLLYVYISRAESGGRMWNVYVNRLLACCVLMQLLMILTTGLIRSRWIDCVAAVPPLLIIFAFKIYISRTAERQFRYYEPTPEELEQEKMYSMSEKQTKQSDMEKRFLHPALQHNKLYTVMVHKSQELLAREVLSAYPWFAGKHEHDGVEINAVREENLEYDPSRDGPADEAHQADWDAKSVASTDMLSKSDYPFSSSTTPKYEDAYRHYPFPSSSSSVSVSVMDSPALVPASLPLYPLDNPSTDQLLPNHDRSEQFMMSSVSASAATAPGGLAPPRRQGSGRLYQHHPPMPPGARHVGQVSDIDFSDPSSPLLDSYYVSGDAAAAGGGGDAGVPYPPSAYTQPPLGYVPPAMRRTASDVSESDVAAAGAGAGAVTRWDTGDREERGYMARQGSQGYYRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK56</accession>
    <name>A0ABR3BK56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611371.1">
        <property type="nucleotide sequence ID" value="XM_066760610.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993018"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="779"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0241989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="879" mass="96756" checksum="2CFE16943331E1F6" modified="2025-10-08" version="1">MNTPTAHDEILADQSLAPLKRNHACRQCKKRKTKCDGAHPVCSPCLRSHAHAARSANRNGTSVPVLVCTWADGEGVENGSPPIQEPIQRLSRPGSASGLKRPAVSQGSRPTRDEENDILRQRIADLEAKLASLPSATKQSESEPIAPELSMPENRPQTSRSDNIVDNWITEVGHIIRYDLNRFGTFGNKETPSSKSSQPSGPSPNFQPWSNGGGIGTTQPWEKSGSGTRIGIDTIPKDGFSSSFGLDDLFVIPADWPRGLPSPFLLEHLIETFFNHVPQTPRMLHRPTLLTRIKLPPTSDNFPFPGLLHAICAAASSHTAWVNNLSPHQIDAAVQRHIIAGMDLTGIEDFGLAQAEMANRSVDLVASACVMGGGDLIFQVTQTCILLNEVYICKGFPLKGWLLGGHAARLTNTLQLSDRNLRKSYKEPLLPRPQNAREREERLATLWMAFINDAGFTSNSTWVPSMSLADIKCNLPTTAQEWSKLDDMLGNPQNPESGDLYTSHPMADAFVLVVKSAILLSEVAQWLRSWFQRPVAAEDELAGPETESFKTVVRHIEDFISTIPNALKNVFKLMDSAYSDGFDVNILALHIFPNVALALLYEPFIEWKPSNQCLKVTQQAYEAILGVLHLIPSNLDVTMIFTPLIALSLYTVGRIIADYVKYATRSEQYSLAVRYRADLTTIQNLLERYGQRYSLGSAMSHFLENYVCYLGNEFMDPSATCIRLERQLVYRANRGTYVMGEANDPYAHLNDPGSSCLGPNDHPSIKSFSDSWSASGPSPCVSTPAKSKTNEPSPAPVCPTAEEEGQDPRLNWDWGREAIKAMGVDASRSAPGLATLDGMPMYMGERSSLNMDGRLPIGSFPDVPEIGGFEGLHWKLDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKD4</accession>
    <name>A0ABR3BKD4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MMM1</name>
        <name evidence="12" type="ORF">I308_105889</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MMM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611642.1">
        <property type="nucleotide sequence ID" value="XM_066760338.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992744"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="36"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="80"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0242260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="471" mass="52490" checksum="0029788A83C04685" modified="2025-10-08" version="1">MYEPFSPNLTFTEGFVLGQASFLIILLLFIRYVVFSPSEQIDHEGWRKRRAERADLLSNHTPPPLSVLLSKTSYDMSIHPAESSDWVNVLLAQILQGYRNDLLSEGGEEGARQRIEGWLNPKGERLSWLDPIDVTSLSLGTSYPLLSNARIRPADGQGRLRAEIDVDYLDSLSMTLSTAVLINFPKPRFAVLPVTLGVELVSVGGTMSVQLHEPIEDRQHIHANLLPDFHLNLKVTSLLGSRAKLQDIPKLEQLIVSRLRNLIQDRLVHPNHISLALPRILSPSVSSTPILEGLGEGAVDALKDAVSDGVKRMVEDFMGENPIEGALNEQGEEQWVDENYPPTPLVQPPGTFPTLSESSRQSLPPSRPQSTTQGQPQLFYRRPLIHPAQTYHHYNTYTLDPQIPHSVSYRHPPRESRIHNAPQTPVPQRPSHGQGRMSTASSLTPSQSQSQFRFRGQFASNVNPGQVGTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKJ4</accession>
    <name>A0ABR3BKJ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611697.1">
        <property type="nucleotide sequence ID" value="XM_066760393.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992799"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0242315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="210" mass="23304" checksum="913AA4DD911A6F5C" modified="2025-10-08" version="1">MHVTQLYSPAVISLDGSPSGTAGSRVRHPPIHIYIKHDTRLLSFPLCRTRELRLSAAPRKVDPWCDHVKNGMEHGLDTVLCPGLPGRASLSFLEETAARRLKGYKPVMSKRTALRIRSSILWPEKNRMLSSITKKISSGPLTSWRSSDCLGYALCYSLLGPWGHDLDGILGYLYLCIGSAATSFKLSSTLFNRISSITNELLTEQRAFCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKR4</accession>
    <name>A0ABR3BKR4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611762.1">
        <property type="nucleotide sequence ID" value="XM_066759816.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992215"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="6">
        <location>
            <begin position="85"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="379"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="741"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="862"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="952"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1163" mass="133056" checksum="D6A9A4FB6C124B25" modified="2025-10-08" version="1">MAGEPSTSRSKRQRVSSDNEDYATSSRKRRQTQQENEEPENEEDEAMRIMLNEEFDGIDEEYADRGDDFLPKYWRGDDGYVAGSVVRIKCINFMTYDHVEFRPGPHLNMILGPNGTGKSSIAAAIAIGLAFPPKVMGRANEVKSYVKQGHDEAQLEIELKGNAGEENPTIWRKFNRHDERSEWKLNDESVTRAKISEIIKSFGVQANNLCSFLPQDKVAEFAKMAPVTVLKETMRAAGDPRLTKWHEKLVDKGKRLKELEIDVDRQTVHRDRIQTQVDTLAPDVEHVQEREKREHEAEVLEHLLGVSEHAQLKEASAWAVRLHKKIKLKVERHEAGRRPLHDLEDSQDGMYQKLRGKFVQVKEKIRGDISGVRGYVDEIEKIAKKGQAIQNNISELRKKIERKEGEKNALRKKIKLCEEILTEPRENHEEEIRAKKTEKHDLFQQGKDLSRDLESLKKDYEDEIAVLQRIGREITNLSNRQRELENVETQKEKAAREFSPSIAYLLDWLKEHGGELEKPVHKPPMISVNVPNKQYAWQVEFCTNAAQRSTFICESKADYDRLIALNNKPLPEYLRRNRGRWNNGPNNRNGERMAPENLIRMNLAYQEVTDKTVNPPRPQPVSVLNRFGFDGYVIDYVDAAPAVIAYLCNQCRMHATAVTQKDASDVKVDELPGMGIRSWGTRNDWTRVNQSAYGNREYSERVQAKSEAKSFNIGVNTAAVKEIVKEIAKLKLTIRDLEEPHAKMKQKIDAIESKRRELGQQYDEISKEIEELQRSSKRYQKAQLDLETATEKLQALESEPFSDEIREKLRKEKYDNAKLRLRPLDSCMDICDNMFDQCGDLIKIGFRQIQSEANVKAIKAKVNDGNARTKQLRKDMEEAENEMKISKARMNAKWAAIKERIQPASRSVRNEVTRRAQAASIPSPAEIQQELNIIRNQLEMTINIPGNVMQRWEALTKQLEEATAKLDAVETELSEVREVVTATRNKFEPALQTLVDAVSAKFSAAFKRVKCTGEVQVLKVEGDFAQWGIKILVSYRDIDRLKVLTGTHQSGGERSLATITYLMSLSEMSRTPFSLVDEINQGMDQRAERAVHNQLVEVTCDSQAGQYFLITPKLLTGLTYHPKMKVLTINNGVFLPDSVDTTQRYGSLKGCLKKYQKAHGIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKU8</accession>
    <name>A0ABR3BKU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611792.1">
        <property type="nucleotide sequence ID" value="XM_066759846.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992246"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="74" mass="7997" checksum="848CBE18273CB543" modified="2025-10-08" version="1">MSNLPAVEHPIPAGSIGKTPFDCCIAAIIFLAIPLEARPHNFASTFSLLTLSSTSGDFPHLKGEKLHIKPFRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL33</accession>
    <name>A0ABR3BL33_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611530.1">
        <property type="nucleotide sequence ID" value="XM_066760226.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992632"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0242148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="112" mass="12980" checksum="83AB366A61163E3E" modified="2025-10-08" version="1">MWRRFREVGKGVGMVPEKGYTAYPDANILGVFKGVVYLLKKRLEKHRQLEQRWVADGLSVLWDAHMVPENFRQDQGVQRQYQDLHHRALAVGNRTTKLPCPLAGHVERDDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL90</accession>
    <name>A0ABR3BL90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NCA2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105527</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611927.1">
        <property type="nucleotide sequence ID" value="XM_066759981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992382"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="67801" checksum="82E2C76A464CFF5D" modified="2025-10-08" version="1">MTSIFHSQTSSYASEQLKSQLSALSTLPISFPPSTQLHVQQSTTPKPLLQNALSDLSSSKPISKERLQQILEDLASAKEQEGYAAEQLSEIDELVEVEVMGRAVTFLWKEVLDTFIDGALSLERERAWWDGVLNSSRGVSFYLVQTMPHRLWNAIPPRSQLSLPNFKTFKFPSKELLFKPLHSTTSAALTSITSPWTLTRREILTTRSELTHARDSAAHRIGVLASQGPQWSAEAREGVQAMGDVASETQRVYSLLRSVLDVPLPKPRKSRSATPPQSIPTANALLSLLTTHLSQSQDNLSSTLSVHSRPGRLTRLWFPFLFLPPTLYFTVSIIGRNKDWLKEQIRNGKETIRGFFVQWVWEPLEGIGKTLRGGGEGLGVAPTTVHSDQASLERMVMDLGRDYYHLSGPQLQALGDRVKNGDMEEVLRVYEREMQSPLKNAIMGSLVRTLLIQVQKTKTDLSLSLLSLDHLLRSQQLTFAFVGLAPSLLILYGFGGWLQGIWKGEKRGKSRRRAYFHSLRSIERLLITSPDGEMTHRDRGLLIISVSNLRSWAVILGASKREAFLDDLRMVENPILKREDKLRVIERVWRCWGVDGRGRAFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLF7</accession>
    <name>A0ABR3BLF7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611650.1">
        <property type="nucleotide sequence ID" value="XM_066760346.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992752"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="416" mass="46036" checksum="687CEB9EA01F41D2" modified="2025-10-08" version="1">MSGEKNGHNEDAPSNAGVRRPDGMLLAYTSYRFASRYEMPQLAVVDEGKIDVQSSDIPHCRSASRTTAKSSVSQVTQTGSHATSEKVTPVVFPTPSKPSTRISSTFVKGLHLDPCEAAYIITPLTMALKAEESDVRMCLLQGLAYMDVKAFEDAYDFALTGLRMVVDLASGERLCRLKAPSGESWEQLTNENIARKNEQMRLYKGAAMLDKMSDIPSQGTTMETADIVESQEGNKSEVTEKVKTRIKKKGVTARSRSASTKYTFSGPISFLRWSQREDVLSSTLSHPITPPDIASQWLFDPFTNELCASNEGLKMCSGVNNGPENGEAHSPVLEPVEEEEIKPLASQAVDENEPDIPISQRGDEEDIVDEMKRREEERKLYLALYSALEKRGFRFLWGGQKVFQAVLEELTDQSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLW4</accession>
    <name>A0ABR3BLW4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_105414</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611815.1">
        <property type="nucleotide sequence ID" value="XM_066759869.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992269"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="12">
        <location>
            <begin position="27"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0243448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="346" mass="36090" checksum="559EB628C9AFC7D2" modified="2025-10-08" version="1">MLYRSALRASRAFTPRLALSHSRLVSSLVFLEHKAGKLSEASLSAVTAAKTLGNDTHGLLVGTKSEIENALDRAKEIKGLSKIYLARSDSYSHSLAEALASLLASIVSAKDVSHIFAAHTAVGKNVFPRLAGLLDSSLIADIIALESSGDTFTRPIYAGNAVLTIKSSPKDSVKIVTVRSTAFDKAPVATGSAVIEDVDIITVDTPTQFVSEELTVSSRPDLASAARVVSGGRALKSKESFDTILNPLADSLGAAVGASRAAVDAGYADNSLQVGQTGKVVAPELYVAIGISGAIQHLAGMKESKMIIAINKDPDAPIFQVADVGLVADLFESVPQLVKEIGNVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLX7</accession>
    <name>A0ABR3BLX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612134.1">
        <property type="nucleotide sequence ID" value="XM_066759487.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991883"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="287" mass="31187" checksum="3B5DCA5E67A252AF" modified="2025-10-08" version="1">MPEQTTISPCCVTGHIHSGNPLGSISIQHGLRTYVSLPCSAHERKAEGQVGKKHDTVILISDIFGIDLVNSKLVADEWAGQGYKVLLPDFFEGDAIPDSLLQSIVPNVRYQAEASALTKAADTAKSAAALGPWLVKHREAVTRPLVEKFVHAVRSDPSTGKIAVVGYCLGARYALLLAQPQSGGKPSVDVVVANHPSFLVLDDVKNIKSTPCIILKGDKDDIMSEDELDKVEEVMKQNLGEKMVVKRFPGAVHGFTIRGDMEDGQEKSQKEQANKDSFEFVAKCFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLZ3</accession>
    <name>A0ABR3BLZ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612184.1">
        <property type="nucleotide sequence ID" value="XM_066759537.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991935"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypervirulence associated protein TUDOR" evidence="2">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="69" mass="7631" checksum="80F34416A074CC7F" modified="2025-10-08" version="1">MSVQDKQGQNIEVGDTVYTPYRGGKHEGQVADIVTTKEEADEKGVLFTDQNKKDVAHKPGTLTDLDKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM91</accession>
    <name>A0ABR3BM91_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611935.1">
        <property type="nucleotide sequence ID" value="XM_066759989.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992390"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="84" mass="9533" checksum="5E07C7234305D492" modified="2025-10-08" version="1">MHGFLIYFIPTTSIPFIIPARPGRLDTPLLTIAVATRKAGHRKASRRDEVENPSLLSSSYLSRPFTFLPSIVYSLFHIIRPTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMH2</accession>
    <name>A0ABR3BMH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Karyogamy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_105626</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KAR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612025.1">
        <property type="nucleotide sequence ID" value="XM_066760079.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992481"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0243658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="60396" checksum="05FD2A824E944FEC" modified="2025-10-08" version="1">MRAHIALPYFIFSTWAKSISGRTVTPNDNHILMEDLADLGLSRDEFVRILGNHPSLHRSVTRSECHSQITARLPLSCGREDDEGQVSESNRRAIAISFTLCSMQSALQPLPNECLPWWQLSEVPVRKPSRIVSAWHPTSPGENDHQALCLGQVLPCPQDWNSYNTFLSDAAQLCHVLRGQQEIAQARELYTNATMEKIALLKHLKDRDQDRLQRETKLKEYIEHQYTELQATSRELKTAYHKMQLVIDRYEFLSTSLDQSIQSLSTGRETLWENVQENIQYQTALAGQLFAKEVHQLQHMLSEKLTAQLGSITNQYGAALSAQTETADTFMKSLQYEMENYLSDLMTQQTAQMATLQDSWEILTYQTSRLVRDMQTLGTGAEALQGVLEQSHDIAISTKVSQELAAARLQASVEQAQRLSTSLNETEGRMDVMLTMFEARQQQLDRSWRWSPSLFASPALISLRQAKLDFAAIGCRGLLVTLDICWQIIYYMLFAPALEQAIWNRPQDKERAVEMEKPTFVNHLAGFMQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMJ4</accession>
    <name>A0ABR3BMJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612377.1">
        <property type="nucleotide sequence ID" value="XM_066759730.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992129"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="779"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="358"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="746"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="819"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="885"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="903"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="939"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0244010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1098" mass="117586" checksum="23AAA5FD2DD57A54" modified="2025-10-08" version="1">MSALRVPLTTIYKHIHTLSLISPTTRIFFNPSTSSYRSNQINASSDSNQPTDACIWTPIQPIFGFHATVPLSYSKTPVLNAHRKELEIYTLRLGEQKRDTSLCPYAMRILRDENQHVAGPSSRPYVYHSVPVPTVPLTSAVQCSTSCPYLDTSPPKSTGDRKPQVTQGAMRRLDGNKRKGMEVTRRQQNEGGLQGSSSSSAYNQDAASTFTPDYYNYTATTASITNSSYSYSPSSTSAYSNYNTSVPYSSNSTYNASEPYYSSNLTSTSISSSKTSSTHSTSKKPPYTASFTSMWSYSATKKTATATASESTSSSYVPGVVLNMTMAGTSDTQAVYSVEVALGHDDGNSRRKRASRRRASYDGDGTTQYVNLQVDLGSSDMWVATTGCSSRDCQNSPYLFDSSLSLDSGVDTNLTYQSGSVDGTILWEEVNLAGFGIGFQALVGATDVQNEDLEGGKFSGVLGLAMPASSTILNEIGGTTGSSPDGATFLDNLFGSGSSAPSKRLFALSLERRQDVRTSSTFGIGAINPTYCPSPCNLTYTPIIAQPSLGSTGYLHWRVEMQGLTVTRFSSEQSGTGETTKTIALGASKVYPSKNYPLAVLDSGGVQILVSSRSYADSIYSAFGITASSDGLYRMPCTQQLALTFTIAGQQIPVHPLDMSYEDPSDVSQKTCIGMIQYSNNLGDTGDFILGSSFLKNVYSVYRYPDTVKHKTWQPTIGLVPLTNASIASQDFYSVRVLHESLGTVSSDQSQSKGGSSSTNSGGNGAAGGDTSKRAVSSAVIAVVSVIGFFVLAAAAFCAWWFWLRRKFGASGAVEYKAAGRKRPPNPQGRNSDHSTSTLRSRKHVDTFRQKSMIEGYDIYNDQDSWVSGTEGADSIRLGHIPEALEEEEEGSGMAGTGDRSSRGSTTARSLASKSLHDEDQEGDVALVDNVDPFPPGLESTTSDTNGRSPRGTSASVSYSPFADPPTSSVSDAFPATGRATTGPYPSPLPSSHTKSNSHSHIKGSSMGMSGPFPSPSGNRLSTMNLDSSPMYDIRTSDYFSVPGTQRGKDGKRLSSSASGRESDHRKASPSKVSGRWLMDNMLVEEPGDAEDNQNESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMK7</accession>
    <name>A0ABR3BMK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612241.1">
        <property type="nucleotide sequence ID" value="XM_066759594.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991993"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29147" checksum="C9C39787720FF81F" modified="2025-10-08" version="1">MSSDKSEVAPYGQSQSTQYKTHPFHARGDISLVSSDGVLFKADVWCLAHASAVFHDMLEMSNPSMAGTSTSESISVPAKPRHPSEPIDIPFPSRTLQLFLDLSRVSDDVMLAITMEEAGDLLSFSHLYDLREFVLNKLKDRAMDLGRRRPWDLLVLASSLDLDDLGVAALEAMNEDTFVRGQKGSTSNFWESIALLQNGWQSRIIMSVIDKPEGGSVRRPGYPDDYSYKTGYVFKLRDWSEAGKRFRNTRLRDDDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BML4</accession>
    <name>A0ABR3BML4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_105282</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612386.1">
        <property type="nucleotide sequence ID" value="XM_066759739.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992138"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046499085" description="alpha-amylase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="13">
        <location>
            <begin position="36"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="507"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0244019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="566" mass="63462" checksum="5E5458FFD9F56642" modified="2025-10-08" version="1">MFIPFSISLSLLPLLLTSLSSSALSQSELRHRSVYQLITDRFARPDQQIVSCDVAKKEYCGGGWKGVEERLDYIRGMGFDTIWISPIVANVQLDPGARAFHGDPYHGYWASNIYELNHHFGTAQDLLDLCQALHDRGMYLMVDVVANHVGAQDHISFVPSSDYGPFSSPSDFHEYCLPDWDVQEEVEQCWLGSQTPDLNTESPHVISTLNTWIHHLVSTFQIDALRIDTVKHVRKEFWKGFMESAGVACLGEVLNGDPTYLARYQREVMGSIFDFATYWHIQRTFQSPRGSISELLSMIKQVHRLFPDPSSLGSFLDNHDFPRFAGKTDDQALIRNAMVYPFINDGYPILYSGQEHHLQGGDDPYNREAIWLFGYDESSATYNMIKSLNNARHIASSSPSFPVLLRPFQHGNHTIVISKAPLLSILNNRGSSSPPSHTTGAATAIPIYIPPSQTGYKGLVPVVNVLTGQIYSTDPYGGLTITIVRGEPLVFIPLILYHSPNPVEVPDSEWKGVPINEKGKGKDSEGNEDRPEMRRRWSPGGPRSSRMMSGFGWWRGWGNGSGKRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMR2</accession>
    <name>A0ABR3BMR2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612404.1">
        <property type="nucleotide sequence ID" value="XM_066759757.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992156"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0244037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="202" mass="22630" checksum="E456BB47F0E48E92" modified="2025-10-08" version="1">MSEHQFFETITKSFTEVTITEQGVDTAEFLEAAEGLVKIFNLFGNPAFAVVQNDLTGNIAKIRAYLAKNPASAATLESLLASEKANIPKAKDRVATDALMWLLRGLKFTSLGLKINLENKDEELSASFTKAYEQSLKKYHGMMIRPVFYLAMKACPYRDTFYPKLGQPQEVVMPKLEAWLKALYEIVEKEEAVFKAGAYGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN04</accession>
    <name>A0ABR3BN04_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Septum formation protein Maf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611655.1">
        <property type="nucleotide sequence ID" value="XM_066760351.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992757"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="247" mass="27012" checksum="225B29C7891F5FB4" modified="2025-10-08" version="1">MVTYNPVGPTALSLPIFKKLANRRVVLASASPRRKEIFANAGFFPEIIPSTFAEDLPHSRFQGHLADYPIATGAEKAMEVYERLVKQDAENPPDLVISADTVVVFPPEKDTAEGGSAHGEVSEILEKPINKDEQARSLGHMSGRKCEVITGISIVYPTVEYPGFKVHSISCSTLVKFYDNTPQTIQAYVDSNEGIDRAGGFAIQGLGGILIEGIEGNYDNCVGFPSAPFWRWMSELDADGVFDEAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN19</accession>
    <name>A0ABR3BN19_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612542.1">
        <property type="nucleotide sequence ID" value="XM_066759055.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991442"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0245458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="415" mass="45280" checksum="97A6C6B8ACE8A5A1" modified="2025-10-08" version="1">MTIRRLLTSLAAHQPSPSQSASRLIPPYSHVYSATTPSTLRPPYSYTASPAQGLSLGAHDVRGRSLKAKVKYEIYHREGKIDGWSAWAEDVLGDEEQRREVEAAWVETLAGLESIKSSGNQIPQIAFHSLAGHLASESTVDAIRNTGAVVIRDVVPDAEAIEWAREILHAINDAGERGIYWNPALIAARANTSVLSANTQLARSLLGQEVYIQADTVREGIAPFRTTPFPYDPWSSPRALLAHLALTPTMSSPTGAAPQTTRLPPSVHAATYTLLRPLFRPLKSKISFYDSSSYLDPANWVLDPTISHRPSPAPDFPHLAGTEVVLPELLPGDVLFHHTALPLSTQPVGQIFLPIHPVEKRGNEAWIVKQREAFEKGVPPPGVSEVGDDLCVVEPRGKRSDIGSRAGREAMGYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN39</accession>
    <name>A0ABR3BN39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome c oxidase assembly protein subunit 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_106195</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611403.1">
        <property type="nucleotide sequence ID" value="XM_066760642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993050"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0242021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45254" checksum="C4A2007645C16847" modified="2025-10-08" version="1">MLATSLRRAIQTSIRAELSNAPIAPRAFSTASPAFTRPTPRPIGLPYFTPCTRSSFFFPSHTFKFPRSLSTAVPKEQVHSDIPKSLPYWLYGCSAVVFGIIVIGGLTRLTESGLSIVEWNPITGILPPITKEDWDTEWENFVLPTVYYLARYKLPRPLPTKLLLIGLGIGFQGVLGWWMVKSGLDEQIITDNSVPRVSQYRLAAHYSAAVALYLGMLSTAIGIQRDMKLAKNPAIVSALNVRAVKKFRGLIHLSGMMVALTAVTGAFVAGLDAGLVYNEFPMMGDGLVPPKDELFDQRYARSGSDKIWRNMLENPVTAQFDHRVLATTTFTILCTLPFAARGLAFPAARRLAALTTAAAVTQVTLGISTLLYLVPIPLASMHQTGSVVLLTCIMALGGALRKPSKMIRYIRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN80</accession>
    <name>A0ABR3BN80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104655</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612607.1">
        <property type="nucleotide sequence ID" value="XM_066759120.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991511"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="9">
        <location>
            <begin position="1163"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="10">
        <location>
            <begin position="2983"/>
            <end position="3318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1206"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1845"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2228"/>
            <end position="2311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2666"/>
            <end position="2702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1214"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1848"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1870"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1901"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1950"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1977"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2228"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2260"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2673"/>
            <end position="2701"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="3286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0245523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="3318" mass="368009" checksum="C55B767D4101A057" modified="2025-10-08" version="1">MKVKKSAKKQSPPPEDVAALIKRILAASDEDLTNVLKQFQVWRYPRGDLHAWIQVLDRFDNLLGEIIKSYDLTKLQINDFTPKTKDMLLEILRVQRILMENCTNRKLFNSYDRLSDLLLTNDLNVLLATVFVLLRPAQQYAISTPLDPPQRHAILHRLLVLSRGWESLVHSGLDLTTIASADEVVIPEQLRQVQIHFYPTVQHQEVPTSDKSPVKMLSSGAMETPTRQRPFVFGKVGTPAARQGGASSTSSGQSVVDLGDVSTMEDNFTDQLSALAEKNYIPLEEQFATLNRLRLIILMKDQEIRRQLLSIRLFALATYVYLASEDAAQSNLFLYEPELVSQLADLLRSSSDVGEQVTTGTLLALCACAHHQAKMGEVMTSVSANVNHGVLVTFFRHLNERLVAGEAVSFELIDATMSFLAFVATSPSHSNMLMGAGILRLLLEMLNTSGDRRENCIPRAAGLIDHIVFSNPQGLSNFSSIDGVNNLVQRIKTEIELRLQAHDEAASEIISEGGTEGLRNLVDSDLPKSLKVIFQHSPKFGSRVYALAINTMATFVHNEPTSLAILQEMQLPQTLYAQLEKEVPSSSDVLTAISNAIGAVCLNQSGLDYTVAHPDVINNLVGTVMSTDHAQVFNERENARALGLSLDELSRHHPSLRPVIIKAIVGLLRQAIDTGAAFEPAVDERSDYIIEEMAQQMVPSLETQPAKASPSNPILAAFTRIFRVLGGLLRNPTIVKDFVDAGCLDLVFAMTDTPCWPIRFGNTQASTSLAHLTKHAIEHCYPQFIDAIIASIRTSLAHCTDIWNETDAHKKWKAVREGTADAELLGRFKTFHSIFVRLTLFADALYALSMTNSRTVTSVIKTFNVQEDPSFIVDLGKIHRLCFRYHILSRSSEPSISKNSAKEGENSKESGVRYLSTRSHAILTKFFKCLVRLIYSKRGRDQAHRDQAQALSVCIADILIDHLQPLPDSTMNRFSVDGFALGTVMTMLFDGRGLDGHLNTTLFLAFREKGGFDATLSTCTRIISHMEETMKKQTGDSVATQEELDTESVAAIKTVLLVLNSFVGPKALLDSPETHALQFAPPGQPKPSFAATNLFLKIRVTIFPLARRIWQASWLLSCPTPVIKIAVNCFSTLVEGKHEESTDPEAISRAIHIVAQPRPVVVTADPTSVNQLVDMGFPRQGAERALVRSRNNITAATDLLLTMPDEFVDDASGGDNQAGPNAVLEQSNQEVEGQPAQSDERELDSHFDAANTETDNRENTSVPTDEDVKLKEQLQEMRKEYKEGMSDRALEIVDQAEALVFDLLPCVPSGQTGITFVVDSLSDACVNYRSDRDVMISARLRLASVCLRSNESVVFSNELQARSAEIFDALPLEEARRPSWLPALLLFAETVYGLQSFIKKVKLGDSPEEEVTAALVNQLRSEIPRLSTICLTTIRADDSTRDELVAAFRLLALLTRVSEAGISSSVIVDCLQPFKKMSEKLAGCHPFLVLVIRHLLDNESTLVESMQGEIRNWLSPARNKVADIQHFVRQLRPVALREPNCFLRAVKQECALVDPTPPQSVYHIRGKVESKDGPLATKSVDSSLESIGEETQTIINFLLGELSQAVRASFEKPINEELPTEIKNSAEQAYSGLVMSALTESLGSYVTAKKAFVNGLKQGTFPGALKAKGGISALINDLICCPVLRPDVSTTPVAGSDPLSLQRLAISSRSTAMVVALCSDVISTGDKKDVPEDIVSIRRTVLDAVAKAIRDTNAVLDNNTRYGRLWALGELVYRLLMARPHATPRQVNNTGLHMAKTMLEKNFVGILTNALGEIDLNYPDVRNVLVTLLRALEHLSKLSVKWGKANKNQREEVDQHQSEEGSDSSNPSDSDSESDVDMLEDEQSAPDLYRNSALGMIGGELGDEDEDDDMDDEDAEDDMDMGEDITDDDDDTVTQTSEDESMASALEHDDWADDLDDDAGDSDEDGEMEQEVILGSADEDGEVWDGESDGQESYGTDDEEDLEEEGIHAEGIFDDDLDDPEMDAFDEEEAYDETTLMEPFQDVMSSEAAGPWGWNQPAERETVRSGGFSRADGQFMADEELLGGPFANNTRSLAEHPLLANQASSSRIHSSRLSDILYAIENMGGTDTIQMLENFVANRQHNGIGPNQLAFSRNHDGSMSVSINGRVYTVGGQSRNIASPNVTPEFVPMTTSQRWQEELHMLPMSRNEASSRLVVHIVNHLLPEARRQAAEKEMMDKKAEADRKASAINTEKDKENGNAVDEEEDVENEDHDWQEDDEDVNMDDSDLDSHMSPDEALVNEEGGADSGPRTLVSIRGRDVDITDTGIDLEFLQALPDDMRADVVEQHMREQRRHQRPASSHIPEIASQINSEFLNALPPDIRAEVIMQEEMENTRRDQPPRPLNIQTARTSGNFFTAIANELRVLQQNPLGPASSSAAAHTTAEGPSTFNQRHREAIQLLEKPGIAVLVRLLFYPHAFKKSYLFRVLVNLCENSNTRNDLLDLLISVVHDGSGDLPAVDRSFQQMSLRGASVSTPKSTPKSKTVDTPSTVIPPGLFSGLQNEHVPTFIAQRCFEALAYIVNSNTNAASYFLTEHEQTAGLRKHTLKKGKGKEKILPQTKFPIVVLLGLLDRPLLAKTPGMMETVTALLLTITKPLADRKLEEKELEIATDKGTESSAKPSATQNSQETSTSPEHVVGKQNSPSIPPPVLKLVVNCLTAGECTSRTFSQTLGAMQNLAYLPECKDIILQELCARCQELGAAAHEQLQELAAALNDESSDVGSLTLVKFSPPTSTQAQLLRLLKTIDYLHLNKVDPDPPADAMTAEEEAVMKVFQSFDFEGLWDQLGQCLSIVEAKGSTEQLATVLLPLVEALMVVSKYRTRFSREIRSPSISPMTSEGIDFFVSFTTAHRKVLNTIVRNNPSLLSGSFSLLIRNPRVLEFDNKRTWFFQKLKRKKSSTIPSGTLHLNIRRQYVFEDSFLALQRWNGEELKYGKLSVKFRHEDGVDVGGVTREWYSVLAQQIFDPNFALFEPCAADQQTYQPNKTSWINDVHLSYFKFVGRVIGKAVYDGRLLDAYFNRAFYKQILGRTVDMRDLESIDPEYHKSLQWMLDNDITGVIDQEFTIEDDQFGEKKIVELKENGANIPVTEANKEEYVRLVVSYRLDNSIRDQIKSFLEGFYDIIPQELIQIFEPDQLELLISGITTVDVDELKNATQLNGWKATDPEVAWFWRALRSFSQEERSRFLMFVTSSSRVPLGGFSQLQGSSGTQPLQLQKLHGKEGGLPQASTCFNLLLLPTYASYEQLRERLQFAITETGGFGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BND0</accession>
    <name>A0ABR3BND0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_105374</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611775.1">
        <property type="nucleotide sequence ID" value="XM_066759829.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992229"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="380"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="763"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0243408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="824" mass="91374" checksum="6DD71A2D2F8D2492" modified="2025-10-08" version="1">MISRQLLRTIHIRAICSQCRQLSTAPTLLRQYIPRSEIKDSSRSNKNRHGKRPFVYTPREPVQLTIDDFKPKPPPKASFLVRSMLQRLPEWATSSRAMVKFKTYGLEASLVRELSKEWLHEVKSSLSGISSEKEARAALERGGWDPEGLLIAISEDRFMPTLESLALRQFLTFMLPSQLLSHPQQTHISSILSATDLTRLTHSTDFLPSRAIKRHFHLHIGPTNSGKTYNALKALSMANTGAYAGPLRLLAHEVWERMNLGSVGGLDGKGRECNLLTGEERRVVHPDAGLLSCTVEMLPLAGLGGAGFDVVVIDEIQMLGDGQRGGAWTKAVLGVAAKDIHLCGDETTVDLLRGMIASLGDDLTVHKYNRLTPLSVANESLKNDYTKVEDGDCIVTFSRFNIFEVKKQVESQAGKKCAVVYGALPPETRAEQARDFNDEDGASKILVASDAVGMGLNLKIRRVVFESLSKFNGKSEVPLSLMQIKQIAGRAGRFKTGNDLTKISDIATPDEAPAAGGVATTLAKDDLPILKELMTWSLPSISRAKLEIPTSGLVQLSTLLPASTTYAELLSHFSALAKPPSLTVIASHDHKLPLAELVEPFRDRLSLGEMDLFCFAPVNTRDERAKEIFTNLIEDYAEEGCVLVDNIFEGLQTNMLDILDQVHEILSTLPPMPLPGQVGSKKASIPPFIINSLPVLETLHKTLVLYIWLSFRLEVAFPDRPKAVEYKVKCEGVLEDCLERMPGLKPSKKGKGPVSKKILKELEEERQRRKQEEDEKKSIEWRSGSEVKKEQSKKMWRNLAFTGEGEEVGQRLDKRLDVGNGKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNG8</accession>
    <name>A0ABR3BNG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612697.1">
        <property type="nucleotide sequence ID" value="XM_066759210.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991603"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29143" checksum="AD504213C47DDE76" modified="2025-10-08" version="1">MAYPRYNNYEQRVPPAQPATYYPAPSTSTLPSREPLSREPHRVLFAGLPPDITASDLRDLLLSEPLHLSPLTTSVTSLHSENGDFQGVMLVYVETAEDAERIRAQYSGQPIDGSLVLQVHHVLPSHVSLPLTNSVTPASVTTARPANQQSKSIPTGPKADSGPTQANQQPQRSTVQRSGTAGKKAAGGVHAQAGSAPPGLALLKRIGKPGQEGDKRKPQGGANKQKANVKSQSAGADLLSRLNPSPGDHSKSSKKNKNTKASNGNAKVNRAKGKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNK5</accession>
    <name>A0ABR3BNK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein MAK11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105239</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612343.1">
        <property type="nucleotide sequence ID" value="XM_066759696.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992095"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="459"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="55851" checksum="B595694B8CD28E73" modified="2025-10-08" version="1">MGKQGKSKATNKGAQRPAPYQKKAKVEVSFDTGVKPSKTEDKPKTSNGKAKKDKEASKPSKAQKPKENKEKAAKVSSPKATKSDKGKGKSIVRPTFGPSTFIVIAGSYEKLLYGLEGSYPDGSTAPALEPIFIFPAHLACVKAVAASPGGKWLATGSEDEFVKVWDLRRRKEVGSLSQHTGSITSLHFPTPSHLLTTSVDSTLSLFRTSDWSLLKSLKGHSGRVNHVDVHPTGRVALSVGKDQTLKMWDLMRGRGAASLPLGSEAELVKFSQKGTHFAVLFPRKIQIYSLTLKLLYTLETKSRFNHLLFHLLPASTEDGEETEVLCVGTEKGVVEIYRITLGEEEESGEEEDDDEDIEKDTTGEGAELERIATLVGHTNRVKAISSLPFLAPTSAGDVRKTIILTTVSSDGLINIYDLCAATADREKGEENKVEPVASYDTKGTRLTCVYLADGQDGTKEIKVKEEEVSESEDEGEDIYGSEQASDDDDDDDDGMEVEFEDEEEEEIEGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNP4</accession>
    <name>A0ABR3BNP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide riboside kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612601.1">
        <property type="nucleotide sequence ID" value="XM_066759114.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991505"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0245517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="30109" checksum="9B217E5CA2D5E1FD" modified="2025-10-08" version="1">MVSNPKYKVVVIGIGGASCSGKTLLAKHIRRALPTDTAIIHQDDLCPPAEQVPYSKQYPDLQDWDDPESCILWPKFRALLRQVRETGRVGEHDTHDHLNKENKIEIDEQVFQRWRRGFEELTKQQKEQGVELAWVIVDGFVLYYDKDIVDMLDIRIFLRVPYDVLKERREERQVYVLQQGGVWIDPPQYFDKIVWPGYLKAHAHIFEDPAVGELKQEWGPKGRDLHVIKPGEGEEGMTEAFDECCEAIVNGVKDGRGIFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNR8</accession>
    <name>A0ABR3BNR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612784.1">
        <property type="nucleotide sequence ID" value="XM_066759297.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991691"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="216"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0245700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="573" mass="62468" checksum="29800006B6E2B4D2" modified="2025-10-08" version="1">MSSPPTPPTPSSPPSYSNLNTPPRAYPQPPAFRSRRSAAAIIPIHSADDSDSRSISSASPISQRSELDDAESVHSQDSYDQPCHPAHALPPHMRSNTLSRVPSNASSLAEEGEATPLLSSGEDGGYHGKWYKGPVFVAAFKLGILFAIFTAIVGITFYWGMPKLDEEDKGTIKLPRSFADLQALNALFQKYKHRYPLKLLACGVVSYLFVQTFSLPGSMYISILFGAAYGIMYGLLLSCICESVGSLFCYSLSAVLAPPLLTLPFYRARVETWRTKIMGDPKKGKKVTWDSIFAILLVLRIAPFPPHWIANFVAPHLGIGMFLFWSSCFIGIAPVSVIHVTIGSSLDGMTSAADFHILSLRNILGLSAVIIAVLIPVGLKRIFKKDLGDLGEAEEALASTRGGDREINVPAVGQSHGRMYHAIDSGVVLATPSKGNGIDMRRKLVKSQGRILEIIPDHESDTEDREHVELDDHSPSPLSRQLISFDNIEEPLVDDNAPGPSSRSSLQSTSHRHDYIVFDPANHFHKIQVKPHRQNTLKGYGTIEQPAPVMGASERAATAAGMGWWPWARDGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNV1</accession>
    <name>A0ABR3BNV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611940.1">
        <property type="nucleotide sequence ID" value="XM_066759994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992395"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="33287" checksum="2993528F12E33415" modified="2025-10-08" version="1">MSFAEERGRQPLHVVSTGRGGAGNLVAHPILDDGFVPGAERGRELSPRPSTNDQVTRSGRGGAGNIRPSSHSRTRDEIRQDAEEEALQEQLIADARGRQAEQGFSTGRGGVGNISRSRSRSKARTPRRESSSSTTRRDGSALGLGRRTTRETVTTGRGGIGNISEEREKNSIELEKELAQNQYEANVLARYTTNEAAHPHAYATGKGGAGNVVVPGPRSAAEPDIAALNSEDREERDAHAKVHANETGHWVPSGRGGAGNMHHRAYDSHSHSPAQDERGRDSNKGGVLGNVLRSFSRAAGRDKSSEGRAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNX1</accession>
    <name>A0ABR3BNX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flo11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612857.1">
        <property type="nucleotide sequence ID" value="XM_066759370.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991765"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045438681" description="Flo11 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="622"/>
            <end position="636"/>
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        <location>
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        <location>
            <begin position="1001"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1045" mass="104756" checksum="39D863AFF31BADA5" modified="2025-10-08" version="1">MKIQPKVASLLLLPLLATSSLAMPNVRRHKPLFRKIYGKRDNETETAEVTDNTTASATETVTASVTKSSSVTSGASSNSIVSSTASFTDSYPSFASSSTYSSSIPGPSNSTDISSSIPVNNTSNSTNTASGLDTQQANPANLSSNAVSSLLESTAAFATYTYSVYKPETVTQTEYHTQYSTEVVVSTSTSISGAQATSSGNDNMSEAESYWDQIQAMAESYAEHMTGSSLPTMTLEVVLEPTQEADGSWEYIIHIGADGTATASPTWVSSTATATSTTPSDSSSGGSANDRYSFTPITTIADLSGASTATSSYSNPYLQSASNIRAPVATSTSSSSSSTSTSSSSDESSSSNADASSSDSSSSDSSDSSSYPSSSEDSGSVSSGTTSSSAEESVDTSADGSSTSSSSAGAASASATSNPYSVPGHASSHFGSDSSSNDISSSSNSGSSNSDSSLNSAQSSPSSSAAASTSTSDPYSVPGHSSSNNGSSSSSSDVSDDSSASSGGESPEGTTSSADAQATSTGDNDDAGSEEEIQATSTFSNVEGQTTASATSVPFPPWYGGVGSDPDDSSSSSNVTLPGNSTIPDNSTYPINSTYPDNSTIIANGSLPTNSSNTSSPLPWANDTSSSIPGNYSNATLPAEDANATTTSLTEWMNATPTSSLADATETQTLVNGSVPVPTATVTESLSAAQSEDVIPSSANASADESISVTESVSSTQSETETETVSATSSSTVVSSPVAASETVAAVEGATSLTESVVPTFTDSSSSSNFISAASSTETNSPTPIITSIASSSTPAPTITSTSSIAENEDGIETDYITSWTTVDYTMTRSLNSTAMATATATASSSENAAVIPSGAASQSTDPVTISSESLTASSSEGTETETVPEAEGSTSAGASVTVSATESASATESVVANFALPSVFSSSASSTESVTGTQSESPSTESASSSATASPISASSESAATAPSYSSSYESISESSPIASTESITATSTASADGASETSGVDENEEGDDCDEDGEGSDLTERDDEYEEVWVDEDEIEEGWEILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP65</accession>
    <name>A0ABR3BP65_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S22-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066759752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992151"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS8_sf"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0244032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="130" mass="14440" checksum="347DA3E6A7BBE718" modified="2025-10-08" version="1">MVRVSVLNDALNNIVNAERRGKRQVLIRPSSKVVIKVLSVMQKHGYIGEFEIIDDHRGGKVVIQLNGRLNKCGVISPRFNVPVDSIENWVAQLLPARSFGKIILTTSAGIMDHVEARNKHVGGKILAFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP87</accession>
    <name>A0ABR3BP87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612972.1">
        <property type="nucleotide sequence ID" value="XM_066758524.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990900"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0247011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="504" mass="58092" checksum="19F148035A9621F4" modified="2025-10-08" version="1">MALVLQPRGPPGDLMIFEDFHAQHQREPVAERKHGWPSRTEKRFKCAYEGCDRAYTKPSRLAEHEMAHRNERPFVCSLCPRTYYREDHLKAHARTHLNVKIKPFPCTREGCKKSFWTASKLRRHEEVHDKDGAYPCDKCDAAFHKHHFLREHVAATHMPPGTKPFICTHESCTASFATKAHLRNHEKTHDERRYVCSHHDHGEDFPTFSKWTELQKHISTEHAPTCPHPECNGRIFKNNQRLRDHLRVHADQQADKAALADRHEEEVPQLLLEGLGKSRKKRKSFAQREAEDNGPRKLRKILNGEVGKDWACQHEGCNKKFKSRYALETHIKVVHQNIREHVCPHEGCGKAYAYKINLNQHLAKHNLYAESSKTASTSESGMLTGMVKEMRRFVCPAWALGVFPENGDIVVPPRCPEPLTEDADGNEQFQSIVRCRASAPESTTTANTPAVLIKSNPEEVTGKRCILRFWRVYDVRRHLKSEHRVDLDDMQVRRLLLSTGQTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPH8</accession>
    <name>A0ABR3BPH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription and mRNA export factor SUS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SUS1</name>
        <name evidence="2" type="ORF">I308_105482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The TREX-2 complex interacts with the nucleoporin NUP1. Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with THP1, SAC3, SGF11, and with the RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ENY2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611883.1">
        <property type="nucleotide sequence ID" value="XM_066759937.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992337"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03046">
        <property type="entry name" value="ENY2_Sus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018783">
        <property type="entry name" value="TF_ENY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12514">
        <property type="entry name" value="ENHANCER OF YELLOW 2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10163">
        <property type="entry name" value="EnY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="100" mass="11324" checksum="59E474A416EBB138" modified="2025-10-08" version="1">MSHVDNTVDEATINAIRQRLLETGDWERIQKLLRAHLEESGWVDDLKDLAKEKARAQDVPNLENLVKQISESAAGMVSANVKRDVMLEIESVLDREVEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPK5</accession>
    <name>A0ABR3BPK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_104576</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612534.1">
        <property type="nucleotide sequence ID" value="XM_066759047.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991432"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="372"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0245450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="426" mass="48188" checksum="69DEED9D41680CFC" modified="2025-10-08" version="1">MDNTPRHLFQTPNNVYILQQPWQFVKELGQGAYGCVSSARNSSTGETCAVKKVTNVFQKKILTKRCLRELRLLHHFRGHKNITCLYDMDIVFDPPGSGQFREVYLYEELMEADLHAIIRSGQPLSDAHFQSFLYQTLCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFQPGAVQTDQGQAGFMTEYVATRWYRAPEIMLSFANYTSSIDMWSVGCILAELLGGKPIFKGEDYVDQLNKILNLLGTPTEDTLRRVGSPRAQDYIRSLPIKPRVKFETLYPNASPLALDLLSKLLTFDPAKRYGCEEALEHPYLAVWHDPADEPLCEVPFDFSFEEEDSVSGMRDLILEEVRSFRYLVRQHSMPPVRRDSHDLPPAPSAPQHPGAGVGPAFHEKANCEGDMEEHPGSALEKQLERQKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPM5</accession>
    <name>A0ABR3BPM5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611928.1">
        <property type="nucleotide sequence ID" value="XM_066759982.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992383"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="51873" checksum="9C0D86214DC2BFA2" modified="2025-10-08" version="1">MGPSLFTITQARWGLDFFVVVLSGVAVASSAPSAAGGAEMYSGRPGDIRGLIVLIGSVGLVGVAALRIAHILLPRPWRLYLDRLEFTLVFMLWICWTSATMAFSAFTLQQGVCSPTLPEFLLPTCPLLTFDLTLLHLLSTSTLALLLVIISSTLSSNYFESLSLFEGQTVGKGSRGYIMWEMALGDVPSSPTGASHPLPPDIEQIPPESWVSYGTLSPTTLHQATWPNAQGMTDAEPTMPPSSSSEPWQSPPKKKDRYAEGRVGTYLPLFLCSLGVACASMIGLGIGESNFSGIFMFIISIMSMIFTILCLKSTASADDGKGQASYSRQVRAFEVAAAASFFLLWPLAAVLFTLFPDIPYRPCSNPASSAAPSPREDADPEDSAIQCYASWTIITLAWTASWIILKRIIGLIFPMPQVKSLVSEHGPGDREEAALLGQNKGKMAATADVESVIDRPRYGWGRVVAGEAFELGDEEDDEEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPU9</accession>
    <name>A0ABR3BPU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED11</name>
        <name evidence="5" type="ORF">I308_105603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612003.1">
        <property type="nucleotide sequence ID" value="XM_066760057.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992458"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="161" mass="17233" checksum="2645D79747F7C99F" modified="2025-10-08" version="1">MSSPAASSKDPLELESLDADSLFAALTGVEKAIPELLMQVKPILAQLSGSPEGGDEERRGIEAREGVEQYMSLLDKIQFVLRQTVYYLRETRSSPNTLRAPPVNLIPTPFASTIPSSPGEGLDGHAPGPAELGLYASRIEAKVLKDMEKALGSLRSELGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPZ7</accession>
    <name>A0ABR3BPZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613226.1">
        <property type="nucleotide sequence ID" value="XM_066758778.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991156"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="458"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="687" mass="75500" checksum="BA3B3B613951B420" modified="2025-10-08" version="1">MSAIVTLRAVPTEADTDVLKSIVSRDVRRAYISPATLRTHKVAAGDWVLFKSGSAFIMAQAWPRTSVDDNAVALSLAQINNICGSEVEMYRFKPGQSQGRLVSIVLKEVPLTEAPSSSKLNNGARPPIDLNSPRERVWCKAAIKEALTSLHYVRTGYSLIIGDTEKAPRKFEITSVEVSSKGIEKRLTSIEDGMEELAIGEENPRLYEMHWRTSVSLEGEELQLNKEVHTDTPSERKTLNKKGSPNMSTSSVPHYINLFTPTESPVSAYTFLGGLQSQIDQIKTLLDLPMLHPDLYIRFGLNPPRGILLHGPPGTGRFDREIEIGVPDVKGRREILDIMLSKIPHSLSEEDLSSLAARTHGYVGADLFSLVRESASAAISRFHLSSSPSHSEPVLTNVDILSTLPSIRPSAMREVFVETPTVRWSDIGGQQDVKQKLKECIEWPLIHRDTFKRLGVEAPRGVLLYGPPGCSKTMTAKALATESGINFIAVKGPELLNKYVGESERAVREIFRKARAASPSIIFFDEIDALGSARSDDHTHSGVLTSLLNEMDGVEELSGVTVVAATNRPDVLDSALMRPGRLDRILYVGAPDFETRKDIFRIRMATMAVEPGVNVEQLAEITEGCSGAEIVSVCQDAALAAMNESLDAPYVKGSHLVNSAHTVRRRITPDMIAFFEEWRDLSGVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ47</accession>
    <name>A0ABR3BQ47_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104358</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613283.1">
        <property type="nucleotide sequence ID" value="XM_066758835.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991214"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="5">
        <location>
            <begin position="181"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="324" mass="37314" checksum="CF6A507507578EA6" modified="2025-10-08" version="1">MSTPTTAPALTPAQARLAALNRLKAKNKLASSTSSSNTVGPSTGNHGNAGPAYVNRREAVPSSARNMVQQQAEADKAKPLPLRRDPSLGKYFEYDLSKMRNSRGGFLTEEDKEGDRIKSLAELAREKERQLQMIREGEEPAIIPDRSPRCVECGTLEINYQFLKVFDVKVCKSCEKKSPEKYSLLTKTECKEDYLLTDPELKDVDLLPHLLRPNPHASTYSNMMLFLREQVEKVAFEKWGGEEGLDNEWKRREEFKKRKREEKFEQGLRDLRKRTRNNLYQRKQEAQHIHEFEDVEEVYDEQEQTTKLLQRCFGCGSEQEVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQB3</accession>
    <name>A0ABR3BQB3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613339.1">
        <property type="nucleotide sequence ID" value="XM_066758891.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991270"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="111" mass="12598" checksum="F79EC7953DF5A2E5" modified="2025-10-08" version="1">MADVDMSSALAQRSNLRYGMNKGRPTTVIPKTARPSNKKGVKTEKKTFVKSVIREVAGFSPYEKRVMELLRNSKDKKAKKLTKKRLGTLLRSKRKIEELSAVIVEQRRAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQG6</accession>
    <name>A0ABR3BQG6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="9">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_104476</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="9"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613401.1">
        <property type="nucleotide sequence ID" value="XM_066758953.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991332"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="13">
        <location>
            <begin position="36"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0247440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="335" mass="36604" checksum="5EDAC883EBACC3B1" modified="2025-10-08" version="1">MPTPLTLLLSAIAIIVTYFTMPFWPFRKSNYDPRGKHCYITGGSSGLGKALAERLVKQGAHVTIVGRDTKKAAGVVEELKTIAAPGQIIQCISADLTSPTASTEAIHAACKPHADQAPDYVYLCAGFSQPKLFIETTKQELKDGLDGVYWVSAYTAHEACQMMTKQRRIGKIIFVASFLSYVSFAGYSSYSPAKYALRGLSDALRSEMLLHNIDIHIFLPCGITGPGFDAENRTKPAVTKKIEEGDTPIAPEVCAAALESGLKKGYYQITDNLVTEPIRLRSNGGVPTNNFLLDTLWLIIGSVGVPIWRMTADSTVRSFRPKVEKELQAKGYYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR69</accession>
    <name>A0ABR3BR69_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105349</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612453.1">
        <property type="nucleotide sequence ID" value="XM_066759806.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992205"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0244086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="453" mass="49860" checksum="ACF0DB61A9D2BDEB" modified="2025-10-08" version="1">MRRDFGVPEVDAALGLSLYGWGFAVGPLVLAPITEEYGRYLVMVVSVVSYTILHLMLSLGKNISTILVGRFLLGLTGCIGPTLTPGFIADIYPPEKRGSPMAIFTFILLAGPAIGAMSMGFVEANQHMQWRWVQWIQLIIMGVFTPLMIVGLRETRSLVVLQRLAKRLRKERGLQDGGRYTARAEINRMHLLPALKRSIGRPFLFLFMEPIVTSFALWTAVVWGVYFIVISGLPYVFSKLHGWNIQITGVAYLAVAVGSFFGFLGNFAQDAVYRRRAAKDGTEGRLWASMVAGVLFAIGCFVFGASATPGSSWFGPCAGVVLVLAAAFTILQCCLVYLANCYGAFASSAVAGMSFLRILLGSSFAIFTENMFSTLTVRYSLIMMGGIAMLLAPIPFVMFFKGPWIRDHSPYSKRLIAEEQKRLDESEISNLEPLAQNESSGATRESKERRESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR87</accession>
    <name>A0ABR3BR87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612765.1">
        <property type="nucleotide sequence ID" value="XM_066759278.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991671"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0245681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="362" mass="40628" checksum="4B7B500EEBA56655" modified="2025-10-08" version="1">MPPQTVPCQYKTGKTLGSGTYAVVKECVHITTGEYYACKVLNKKFLMGREHMVRNEIAVLKRVSAGHKNIVQLHDFFETTHNLYLVFDLCTGGELFDRICAKGSYFEKDAANIVRTITSAVKYLHDQGIVHRDLKPENILFKSKAEDADLMLADFGLSKVLDDDKFNILTTICGTPGYMAPEIFKKAGHGKPVDIWAIGVITYFLLCGYTPFDRDSQYEEMQAICKGDYRFEPTEYWAGVSETARQFVRNCLTVDPTHRPTVDDLLNHPWLRDVEMSKGEPAEAKGVDLLPTVKAAFDAKKTFRKAVLGMMAVHRLQDHGATINGQTEAEHEKLKKEVEAFKEEAAQEEVKEVIQPGAPASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRI7</accession>
    <name>A0ABR3BRI7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104621</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612573.1">
        <property type="nucleotide sequence ID" value="XM_066759086.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991477"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0245489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="500" mass="53611" checksum="6B8C6736EC8A7404" modified="2025-10-08" version="1">MSSFTQTQDLATLLSDPSLFKQKGYINGEWVSASDGASFPLYNPATGAKIADMSHMPRSQVAEAINAAKVAFPAWAALTAYQRQAYLLKLFKEMEDHREDLAIILCTENGKPLAESRGEIAYGASFLTWNAAEALRTYGQTIPSPYPGTRNTVIKQPVGVCGLITPWNFPNAMITRKMAPALAAGCTVVIKAPAETPLSALAMCVLCERVGIPPGVVNVVTMDKGDREMAAGLELCENVKVSKISFTGSTPVGRLLMKQSSGTLKKLSFELGGNAAFIIFDDADLDLTVDSVITIKFRAAGQTCISANRIFVHTKIYDDFASRLIKRVKSFKVGDGMEEGVTIGPLVSQQGVEKVERHVQDAINLGAKVLVGGKRIDNGDGSCFYEPTVLADVPRQCAVADEETFGPLAPLFKFDNEDDVVERANSNEVGLAAYFFTKDLARTNRVAEKLEVGMVGVNTVAIAQPCAPFGGVKQSGFGREGGPSGIDEFMVDKLITIGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRS5</accession>
    <name>A0ABR3BRS5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103686</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613570.1">
        <property type="nucleotide sequence ID" value="XM_066758168.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990542"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="8">
        <location>
            <begin position="224"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="888" mass="97876" checksum="E7CEB1F0D647509A" modified="2025-10-08" version="1">MQPFYPHTPQTTRHLYAPSTPDSPSFEKESHFSSFSSEEHARQKREAADGVVRDYEEKRDRLAKAIESSVYLLADFKNFNGQQWTVRYPHLRSSESVQSGSSSPRPGMTRRTLTFADEPSQLTEVVLSSTPTARHSLKRSLSVAPAPAPSPSPSDDSATLVAEPATIDQSEDDFSILRLDLNMGATRHAKHLISHLEKSSISALLDNRITASLDHLTNLQKRIYDAHSRVLVTGDLNAGKSTLINTLLRREEVMPTDQQPLTTRFVEVVSAKENENKEEIHVLDKSDPYNPLDKSTYSVLDISKLEELVTDPDSDASSPPLRVFLREADTDVANPSILHNGVVDISLIDAPGLNRDSIKTTANFARQEEIDVVVFVVSAANHFTLSAKEFIWQAGHEKAHLFIVVNRFDQIKDKARCRRLVLEQIKQLSPKTYEDADSLVHFVDSAKAAMGYAEGEGDELDDAFSHLEHSLRSFVLVNRFKSKLGPAQNYVTHLLADVELLAAANSLVASKERDIARDELARVRPVLEKMKKGREGLEDGLVHEEEDVTEQVAERTKKGMTTALERVGRGELAAPAPGLHLPSYPGLLGVWDYAAEVKRVILASLDFAVSLTEDDARKLTAEGVDKVIALGDAHLPEDVERSNRRFNPQAMFTARTRARRQSGISSVGLGLAAQSHLKEVNVADIFDLQHHIFIARSALPSSSSSSSHSSLDLIPVSAESFGAASLAFGAFSMVSGKTVGLRAAIEGLAHFSDFVSNPSTRRWIGPVLGIVTAGAIAYVIYDLPNSIPRNVGRHIQSTLLSSSGNPVSDDAAVAFPDAQAARVSKEVRKVMRLAAWDLRERFRAAIDARGELVRESEEQEKKANKALKWFEEVEKRVDGIREEVGIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRZ6</accession>
    <name>A0ABR3BRZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613907.1">
        <property type="nucleotide sequence ID" value="XM_066757523.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989877"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="55"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0249720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="344" mass="37570" checksum="29E61EC6986A9FD3" modified="2025-10-08" version="1">MSQNKDIEASIPLNAMPRASDVEHDLTHGEHVEINISEARPPAKQQKKIVIPAIIIIPIWMACSISVILYNKYVFSGLNFPYPTFLTTWHLIFSTIATRVLQRTTTLLDGAKDIEMTREKWMRSILPIGALFSGSLILSNYAYLTLSVSFIQMLKAFNPVAILLISFAFKIQEPNGRLIVIVLLISTGCFLAAYGEIHFELVGFLCQCAALAFEASRLVMIQILLHGMKMDPLVSLHYYAPVCAVINACIIPFTDGLEPLWNLHRVGILVLFTNAGIAFALNVAAVFLISVGSGLILTLAGVLKDILLISGSVLAFGSPITGLQVFGYSISLSGLILFKTTGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRZ7</accession>
    <name>A0ABR3BRZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103734</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613618.1">
        <property type="nucleotide sequence ID" value="XM_066758216.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990590"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF3">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="252"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="445"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0247657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="476" mass="51639" checksum="7A957C46506B3C1F" modified="2025-10-08" version="1">MASAKHKSFPSYASAATSSATSTSTATGPMVSYHTHHPLNSRPSITLSREASPPPRASMSALHRPAFVHATTSYAIGAAAGTAAGSSYASGHGSRGESRGGSSKPFDDDGGYVKEVSAYYPPESPHPHRPYPYPHYQYTPFAQPDRPAANTCAMDRLKTSVRTMCGANGDRESKLACLQCSSAEEGGQLGKIMMWAWVVTTVGFFLAIAFWRGELFRALDKLSHYLAGQGIYGHLTFYALIFITTIPPLPLYSTLIILSGYTFGVWQGFLVSYLASLSGAIVVFLASRKMLRDTIVKSLASSSVSMSLLHILPTHPHLLLLIRIAPYPYNLLNVILASSPTLTLQTYAGCTAVSLCKLVLHTWIGSGIHDLSQSYGHDQGKAQEGFKEGDEIDAQDPDSATAQPAQEGDTQAAKNWTTWAGIVLCIALFFYLTHFAKQAIKKAQAEQAEMEEREREEREGLTSVSVRRQSEAQEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS06</accession>
    <name>A0ABR3BS06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613928.1">
        <property type="nucleotide sequence ID" value="XM_066757544.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989898"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="9"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0249741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="278" mass="31654" checksum="965C5A1ACD370B6C" modified="2025-10-08" version="1">MPASDELAIDCQSLTYSWKEGDDPVLENVNLELQKGDRCLLLGANGAGKSTLLRILAGKRLTKTRTCRILGQDVFMNPPGGVVYLGTEWSSNPVVRSDIVVSHFLDSVGGYRHRERRDRLLRILDVDLDWHMHEISDGERRRVQLCMGLMGEWDVLLLDEVTVDLDVLVRADLINFLISESETRGATIVYATHIFDGLKKFPTKVCHIQLGSTPRELVAWPPDGKGSQEETLFELALGWLREDRDLRRQKEKEEGRVRGPKTDTKDAKTFFEKYDYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS54</accession>
    <name>A0ABR3BS54_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">(2E,6E)-farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="3">2.5.1.1</ecNumber>
            <ecNumber evidence="2">2.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="3"/>
    <dbReference type="EC" id="2.5.1.10" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613955.1">
        <property type="nucleotide sequence ID" value="XM_066757571.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989926"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0249768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="374" mass="43033" checksum="6E2663A30AAEF549" modified="2025-10-08" version="1">MSSLNPEIDGHSYNRPNSGAETPADVKAVRRARFEKVFDQIAEELLTYVKGEGMPKDAVEWYQRVLYHNTPGGKLNRGMSVVDTVEILKGRELSEEEYTNAAILGWCVELLQAYFLVADDIMDQSVTRRGQPCWYRVPNVGNIAINDAFMLEAAIYYLLKKHFRSQKYYVDLMELFLETTFQTELGQLVDLITAPEDHVDLNKFSLEKHHLIVVYKTAFYSFYLPVALAMHMSGVEDRAAFDLALKILLPLGEYFQVQDDYLDCYGKPEHIGKIGTDILDNKCSWNVNTALAHATPEQRKILDENYGRKDSTCEARIKELFSQGPISIPERFEKYEKESYEKINALIEQVDEEKTGLKKEVFRSFLAKVYKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS90</accession>
    <name>A0ABR3BS90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613979.1">
        <property type="nucleotide sequence ID" value="XM_066757595.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989950"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0249792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="15160" checksum="201111917B164DCA" modified="2025-10-08" version="1">MARTHWTASDGHCLYRSFLMAYMGHATDEDVWQLRRRVADKMSTKRTPTSLDRVRGAMIELAGTFHHNFKSWSTLLNFFFKELFQSIIRRVNFKVLLQQDPWLPLQPQHYTMSESCARRRSYMRTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSS9</accession>
    <name>A0ABR3BSS9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614197.1">
        <property type="nucleotide sequence ID" value="XM_066757813.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990169"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="84" mass="9448" checksum="1A31F3115E412583" modified="2025-10-08" version="1">MRSPASVSFKYSSIDNSSPLSLSQGNGTPASKQQRSQRCCNTCLLHRQEREPRNRSTARPSAHSFLLTSTHHTWTCMASLQLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT06</accession>
    <name>A0ABR3BT06_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614271.1">
        <property type="nucleotide sequence ID" value="XM_066757887.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990245"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="170" mass="17941" checksum="8702579F18B1EC0B" modified="2025-10-08" version="1">MSLTNVLPEGTKLSVSTTLPGSSKKHLLSPSSSSGENPPWSSTAPSSLQLYFPTPVAATHVAFTFQGGFVGTNVSVWAAEEKDAEKEGIVNLGLGLGGKIYPEDRNKRQIFAIPFPPSGALPSELEAEGAAGDKTSGLPLLKELKFEFDKSSDQYGRITLYSVEILGPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTB5</accession>
    <name>A0ABR3BTB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TATA box binding protein associated factor (TAF) histone-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614381.1">
        <property type="nucleotide sequence ID" value="XM_066757997.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990358"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="7">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="522" mass="55603" checksum="E8A192FC034AB5A9" modified="2025-10-08" version="1">MPAPQMMGIYPSESIQEVAQSLPLDALGPGAATLLAGDVEYRLHLILQEAKKFMVHAKRSTLMPEDVEHALEALNVEPILIPPRPLALPSFHPLNLPPPAANMPSQTIYTTPDDEIDFVSYLKEPLPAGIASSAGVKWKAHWLAVEGVQPAVPENPAPSSIHPGAGAGGSGQRVKGAPAPASTTLKPSARAHLPQELQLYFTRLTTALVPPAATLPESEPERHRLAALASLRNDVAVAGMLVYVVKWLCESIQKCLMAPTASIGHLVDAVGALLANEGLFIEPYMHQLLPPLLSIILTVPLGPHPPQPASSSQPSPTEIRSRASDVLSKIASTYSPSYPGLIPRLVMTLTKALHSPPFPSPLGAANPPTGRYEGAILGLGGLGPQAVREGIWGEKGEGVRRIDELAGRLYSEAGKRKNPLVRATIKALAQIIPPKPSNTPTPSLNVEQITEMFGPNIAAGLSKKGWTASEMVRMREEETMKAGSSDVSENEKVGVKSERQNREGVEGGEVEDEKMEVDTPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTB7</accession>
    <name>A0ABR3BTB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meiotically up-regulated protein Msb1/Mug8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614369.1">
        <property type="nucleotide sequence ID" value="XM_066757985.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990346"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="147"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="717"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1297" mass="143298" checksum="4691B3E1D02EB166" modified="2025-10-08" version="1">MTSLFRSRRDKVNKTLPATPPKGTQATTPNGKGQVGLSEFGAVANTTPGAVPAKHGQPLTPPQSPLATPVPLLPSKCSFCPTEVPLHVDTLNSIDSFNYSADDVTGLKAYGFLAGVGSRITLGLEEIGWVIKNVGDELVQRALELNQTRARMLIESFIETLSPNDRRRSRENDFIHEIRFAKEHELAWLLRWALSRITRIKEGTRITCHGVMEWEVYEEWRAANYPADAFPFLAQLVPSDVYDLILTPLFHLLSRFAAHSHLSGLTPHALASLFAPLLFDIPTSTTALTSHAIFVRSACATEHLLLASIRSSSTTGTLITDLPFRLKEWVVGYPAMVASDADLARGTPRRGARIIRCERTSRTVRAYTKDLLAHAESWIWEVPNGQEWEAWERITWKARRGSSARPKPSSAWKRRLAVKNIPTPPILSNDLSRSVSYGGTLRPVSIMSGISDMGINKGKDEEEEARYGSLAGKEWSMFEEGGFDAPTEEKRHDIATRLQFDLNESAKLSISERRQTMDWNEFAAPSGGFNRTDPLLDISLSFSPPISSSIASWPKERDQLAKRLHKAQKDAVPFHYNTLPVFGKDVLFLGDDDGVNLGGTGGGEQQVDGKGGVYLEEAWVDVWADLMLGAGWMDREELTFREANWAIVEYKAKPSKMDPEAILDSMSDPRTTGLYILYEERVPLNYQIAIADPKQKKSFTSSFFSPKSKKRAPPTPSSVTRPTSRSCSSSSPKPGGAVAAGWRDTDFERMLLHRQGTKKVSLSKSRNDQPHSTVWHLFADPDPYPVFPLPLKTQTTAGGSPIKLPSPSRIKGNEEKGNFFSTGVKTLGRVKNLEKASSLHRNRNQKLFSASSCGGSSAVPTENSGFLSGSPSKKKERKKEKERQNEQNVEFETHSVSGVSSSETGPDGQRLGGVAGERRKGKREEEKWMNILVSNRGKMQEQDAPPHVLKDKQTAWHPNIVANVDTDASDDIAASYVLAPALEPAAASPRPISYENHSLPLSEPQLQDYTEPPVPEPALTPTFSPQSTSIITLTSLNSSLLLLEEDETRTARASDELLSFQQSLLPSAVNPDQSYLEEERRGRTLGFPEEIGAQLSHNSAYVTVPTTTTEELPAYVSPNELSAPTGQEHGRNPPPMPEKNDPSYFDIPLQIHTPTPRRERDTIHGIVAQYAESHGIITDEGRGSRDDRGTYGTCMRERGSVHSARSCSYGGVVKGEEGQYNDIIGQRDGHWNRKPETDSDGEAGAEEEGEEDGVLRSRVPGMIFDLTPGREPSPARYKHGEPLNFVGEEPEEEEETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTN7</accession>
    <name>A0ABR3BTN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614497.1">
        <property type="nucleotide sequence ID" value="XM_066757028.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989340"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48588" checksum="CA376E47CC8C7460" modified="2025-10-08" version="1">MSSKLFLSLFKTAFLSFHYIPTSLITLPASLGLHFISHPAPTISNYVVSPTTSPLHLPLIFTLVSILVFYLLGLVTGNVSWVDKAWPLYPPTISAMVFGWVLINHAGGVYAHNLPRITLMFGLQLIWSFRLFSHAVKRGFYSPQSEDYRYTVCRKLVPRWAFALIHAFVVASAQPILLMSLSLPLYAALVSPPVTKHTDGWAILTFETISRLLPFRLRKAALPHTAVLNMSDYIMTTVSLLIIYIEYQADKRMYQFQEEKYDKVSSLPEEQIIHPAALQSSETQPLVQKEGLPQPSPYPASHHPGFPTQGMWRFSRHPNFAAEQLFWVSQAMFAGLSGKDNGLNGKGWWAGCVFGPSFALSLLFLSSTTLTEWITERKYPLFKSYKGIVGEFLPQETLYKWAWTKITGSREGLYRAVYRPSPGENEDVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTQ8</accession>
    <name>A0ABR3BTQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent protein kinase inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614386.1">
        <property type="nucleotide sequence ID" value="XM_066758002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990363"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14483">
        <property type="entry name" value="SPX_PHO81_NUC-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="5">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="437"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="523"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="555"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="6">
        <location>
            <begin position="982"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1194"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1313" mass="141620" checksum="A41E59BA43EB0D2A" modified="2025-10-08" version="1">MKFGKTIQSQQVPGWGEYYLNYKALKKIINSYAAGRPASDASLLSLGLRPARLPVAITDTNTTSPLPNFHHHPSSSDAQTDAEHVNIQDLEPLPPQTAPPGNTSTGLMGRNPTESTGRSESFKAHRDVFFFTLQRELEKINAFYLIKERDLRLRLLSLLSNRKRLLRNSSSTAPDASDDLLSPTGARRDAEWASLEEGWRLFERDLGKLQGFIEINAIGFRKILKKWDKRSKSNTKELYLERQVEVQPCFNREFIAKLSDIVAANLLDLENGSEHISTAFLERDPSSSGAVNFASTDGMAGGVGVGSNRSVDFDPDSTRALALDALADLEANLGKAISAGHDALVDWVKVAHARQQRQRFSQSTTDPSLMRILWQCALHAPPTLLPFVLSSLDLDYDCIDNINGRSILHKACIVGSLPLVERCVEHSPELVEKKDVYERRPLHYAAMHGFADIVSFLLQTSSNPSTTDHRVPAEPSPTDMDGYTPLMHAIQRGHLAVVQIFVSDEVTGGDREKITLEPTAMSNDLIPLSLACEHGHVEVARLLLQRGARVIPNSEGLYPQHFAAKAGHSAICQLLVEEGGEEGGGKDRKDKYNLWTPLHHAAIGGEDRHLECVKVLVEKGGCDVNVPDEYGKSAGWYAAWFGHVECLNYLRDHGARLGGARGGDVGASGVGAAGAQVGGRGADGGDTDEEMEVDDMGGLGLAADPQMGALSPGSDLELEPPAEDFELIPSLSLPPPIIPLRVYGHEFLAQRCLIQISLGHRITSSFPPCNSNTPTDTHPHAPAIKLYSRSGSGQDSLHLWSSLKLVMTSKTDISAVPHSVILPLADEREVFSFHAQDLDRFTLELSLYPTFGSKVIGRAILLPGTWRDIKYHKQLQAPLLDHNLKAIGEVALEVSCITPFGGAQLEIGGRVETYWKSKVVKGDSAQDHAHLAPHKPLSVFSSSGAVAGAMGTAAAGAAGHGIDLDAGNETDVVVSSGADTGMSTVPVAGAAGGGGGGESTLVTASSLSGEYVYVVVQVTKDGVPVVYPHGRLPVEEFDLGVSDVSYDQFTALATRLDLALQPPSSLNHQPTASDWYNLLSSTLSSLTDVLTLLPHEIGINLRLRYNREFDSLSDGKKVGRESGEVNKWVDRVLDIVYEVGKKVGGEGGKARKIIFSSFDPVVCTALNWKQPNYAVFFASYCGISRTSSLPTSTSIRTSDVDDIRGPSHITDGHGQGGIRTRRLIPAPQEEESDVRCLSVREAVNFAKSRNLLGVILEASTLSAVPSLVASVKDAGLLLAAFGEPADIGVLRQGADDGRTIDAFVLEGIMTLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTS9</accession>
    <name>A0ABR3BTS9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614534.1">
        <property type="nucleotide sequence ID" value="XM_066757065.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989377"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="72" mass="8534" checksum="DB6CE51F2CE612C7" modified="2025-10-08" version="1">MLIKSINGRWNLVTLEVFDVPRRLSFVSKGRGFLEGRCQEIYELRELTEMRGERCWNSFEKTRLASELPELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUC7</accession>
    <name>A0ABR3BUC7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Bud site selection protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_102711</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614720.1">
        <property type="nucleotide sequence ID" value="XM_066757251.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989567"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="54"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
        <location>
            <begin position="200"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="215"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0250533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32601" checksum="28FE6C80BB64E859" modified="2025-10-08" version="1">MSRPEEISPPEIFYGDTEAAKYTANTRIKSIQSQMTERALQLLALPEDQSAYVLDIGCGSGLSGELLDEEGHVWVGVDIAPSMLEVALEREVEGDLFLHDIGQGFGFRPGTFDGAISISVIQWLLNADSSSHSPPQRLNRFFTTLHACLRNPSRAVFQFYPSSDDQVTMITTAAQRAGFGGGLVVDYPNSRKARKMYLCLMVGQQEIPKALDGDQMDVDEETMEKRRDEIKNERRRRREARRKTKKGKKDVKAKEWILKKKDLYRTRGKEGVPRDSKYTARKRKTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUE6</accession>
    <name>A0ABR3BUE6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614485.1">
        <property type="nucleotide sequence ID" value="XM_066757016.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989328"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="258"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="484"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="639"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="974" mass="110024" checksum="453CDBE76FAC253D" modified="2025-10-08" version="1">MDYLVANSAPRTPTASTSSIDSLSGSSDTKVYKQSRSRSFGGVLRRHRLSWGALSAERLGLGERDSSSEDWSGGIGGKPYNEQQSLGNTSGWSHVNHIRRSSDSIQLSRNAKKDNQSEEFKTTEIYRLPGTGFTGANTLTDSIERRPWQSIRSEGLSRSLLSPGWSPALSDRLAYENLPPASRNPSHRHLTPQGSYSLLLAYQSSAVTSHSSFDLSAASRSPIDQKIASSSSDQELSPEWHQIVDKSFCDSLDKMEQRRQGLWWEIIKGEREYVRDMDIMYHVFIQELRDCRPPVIESTKLEPFIAEVFSTAAILSHAHETILRNLMERQRIEWPLLTTATDIYLQTMLEIVNLYEAYMKNYPFAEARVRRESVKNKEFRKFLESRNTASLTNRRDIFTFLSRPVTRLPRIILLLGELLKVTPKGHADKEDIPVLKEMLERVVKDTEHGIEAAAVKIKLWNIAERLLFKKGEITNLDISDPKRTFVHSGYVFRRIRSESNWHGWQDVYAILLDNYLLLTREEEGGKYVVISRPIHLDFLDIQSTNGAPERRYDHSAHGSYKKNNTGIMDTMLPAETLMYPFTISTGGPKGKAYTLCTTDQAHRSEWINKIQNTQMLRKYDLEGNRIFVAHTISMPSKMQNSVICAETFIIHGRDTVAFATKTSVWLGWLRDTYSFRELVQLQNGQISSIALVPEFSWLLVLSSGTLLAFNLKKMMPTSEPSTWMSMGRAQGQLLNQSGHSAAWIYTGKTKGRRLITYVVHDRNTHGSTLNFLEPMFDNSYPSASSLRPDPVFRSFAALHLPGHASSITFFRQTVAITTEKTIVIAEPGNPVYNCVPTAGSTASLAEDAVIVKLLNGHVGSRAEGTPLGMWQTGGDEFILVYDWGACFVTKFGEICRSGAYLIWDLFPVYAIFRSPHLLLFDDSGRAEVRNVVSGTMCETIKEKGLRMMFPTREDQGMLGWSEKGLIQLVETIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUL7</accession>
    <name>A0ABR3BUL7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614319.1">
        <property type="nucleotide sequence ID" value="XM_066757935.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990296"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="95" mass="10269" checksum="7FFE52535C4F584F" modified="2025-10-08" version="1">MWEQVLYPELPGILAYFPFACRLAAFTLFTPFGVCIILDIVAYAIARTLHLTITPRRVPRSPPTLTSQILTEAVPVTDADSDSLSSSSASSSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUX6</accession>
    <name>A0ABR3BUX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102656</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614665.1">
        <property type="nucleotide sequence ID" value="XM_066757196.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989512"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="526"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="560"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="594"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="696"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="748" mass="82764" checksum="D2525E2EB3DCDA8D" modified="2025-10-08" version="1">MNTHLAARLQQLASSYPPHTALFYARIWHTLAPATDNNHDSLHALALAFLQAAEPYSAIHLVRDHTGLDNLDLDLEIRFERTDKVCGGCAMIVARCCEKLGRYSEGQAVLARALKRGANINLALPAPSSNPATAYLLLANLSHKGKSPETAIENYRKALDEDPWMWEAFTSLCDVGAPPPIESLFPPGAGLSLSRHASRSSRPPLPPNVHRQKSPIEPAPGVLRLHQAQAGVGNSGGLFTPDVEGMGGKTGLGMMGNTSSWDSSSIMGDATFALPEQQTKRPFPSFMSTATSFLPSSLRGGTSTPAGSDSPPKLPTMKRPRGKDPVKRPGPVETPQSQMSSGLPLARELGPNGAKYEDSDAPRRSSRLKTTTSKPSSKNPRDPRVTRSRSVTSSNSNNEAPSPPSLTSQDAILQKESDEYLKDIVKKCARVYKSLSQYQCQQAIKEVDVLPGELKTSPWAMEILGRAFYEIANYVMARRAFTFLQQQEPYRMQSMEQFSTLLWHLTDLPALSYLSQSLISISRTSPQAWIAVGNCFSLQKDHDEAMRCFRRATQLDEGCAYAWTLCGYEAVEMEEYERAMAFYRTAIRTDARHYNAWYGMGLVYLKTDRPRYAEHHFRRAVEINPTNPVLLCCVGMALEKSDDVVQALHFYERASKYAPTSAMVQFKRIRALVALQRYDEAISALEPLTHSAPDEANVFFLLGKCLFKKERRQEATVAFTNARELEPKLESAINAVLVANGEEGEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUZ6</accession>
    <name>A0ABR3BUZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_102988</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614959.1">
        <property type="nucleotide sequence ID" value="XM_066757490.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989844"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0250772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="269" mass="29342" checksum="ED7A0E73CF4B0213" modified="2025-10-08" version="1">MWPFSSSTTPSSAADQPQQHPSAAASTDQCPVDHTTRQAWLANNPSTPHPFHPSASEGSLSSPSAGLSQSRVISSIPRGSTSSSPSAPASASPPAAAAGPSSSVPSSSAAGAESGHAQLQQDANGNWVYPSEQQFFNAMLRKKHNPRPQDMRTIVPIHNAVNERAWEEILKWESQWPSEKCGGPRLVSFVGRPKERTPKAWVKTALGYTPPFDRHDWIVDRCGTHVRYVIDFYTGRQTEGPGKMAFYLDVRPAVDDWEGIKTRVKGWWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV64</accession>
    <name>A0ABR3BV64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_101657</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614988.1">
        <property type="nucleotide sequence ID" value="XM_066756211.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988515"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0252268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="489" mass="56645" checksum="B287F2D0AFEAADE1" modified="2025-10-08" version="1">MAEEKQPVGFRTTSYPAIANPPLPAEGCASFSNYELAASIIFGPWIIQRLLPLPNGWKTYWFLVILFGVPIAVAYWTLKSKFGKRVNEKVQLPGKPISHYLDFKDKELEEKYKDRKIPMQIFHDAYFDKKVDFKGDVLDVMEYRHDWATFEFTPELFKYVFTRLIPDVIFHSQAQDEDQVRDHYDRGNDFYSWFLGPRMIYTGGVMTDINRQETLEELQDNKLRLVCEKLDLKEGDRMLDIGCGWGTLAAFAGKNYNVDVTGVTLARNQAAFGTQRLRENGVPEERGRILCMDYRDIPQAPGYYNKISCLEMAEHVGIRRYGKFLKEVYDLLADDGVMVFQVAGIRTCWQFEDLVWGLFMNKYVFPGADASCALNWVVSQLEHANFEIKSIDVLGVHYSATLHRWYQNWLSNKDRCVAKYGERWYRIWAFFLAYSVISSRQGSASVFQITCHKNLNGFHRVEGVPSHTSLHAPVSRKLEPVISHAEMWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVI0</accession>
    <name>A0ABR3BVI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614295.1">
        <property type="nucleotide sequence ID" value="XM_066757911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990271"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757:SF0">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21671" checksum="A733A24CEA20E8C1" modified="2025-10-08" version="1">MSLRTLTYSYSILYKPFALSSVRGLASKAADVPPLPPFNAETAYKKVKAAQDKWNTKNPSLISPAYTSTSIWRNRDEFFSGTAAIENFLTRKWEKERNYRLRKELFAFDGNKIAVEFWYEYSETDDPSSQWYRTYGLEHWVFAEDGRMKSRQMSGNTVKIANGERWFKDGVDVNKGQVPRGHISPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVI9</accession>
    <name>A0ABR3BVI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein UNC80 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615121.1">
        <property type="nucleotide sequence ID" value="XM_066756344.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988650"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046460">
        <property type="entry name" value="UNC80_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20262">
        <property type="entry name" value="UNC80_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein UNC80 C-terminal" evidence="2">
        <location>
            <begin position="1408"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2034"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2062"/>
            <end position="2075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2080"/>
            <end position="2095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="2352" mass="260106" checksum="5AF6B5D8AC2AD212" modified="2025-10-08" version="1">MPLHQDTLTPSGNRQPSGPRPRPLRSSAASTASFPKSTSDAPIPTRPSTTSLSKLEYRTESPLDALLSLESQYTVSPETSPKLPEAAGPSRQVSEYEPLPPSTFRIHPPKRGRTQIIQDAPSNREASQTRSKSGPDIRDASPMPTFSITSRPSTPTSLATRTSKPKPKPTRLNTDVTSSSSITSPAKVVSPGIKHWQQVRAHVLAPTPIEERQQTTRSGKKPGLVSKAAGRFGFRHAADNVIGYTDRRRSMNGLLAELGDLTEEEKETIARERRKFARDIKACLDACALEESRRRLYRIDSNQNTNHPDDARPSAASIHSAAIHAHPHAAQRFNFDPSFSAFAPLLTELHKYLPDARSKKPWSRTCPHHSEILAELGVAFLNDSTSTDGEKQQALEVFGTIVKNWAADTPDEVMARWQWLCRALLTDDRQIRSRGLALLDDFVHFHPSLPRGHEDPHTALSFLALASDLLILLHAVQTTRYPEASHLCKVQSFIDELRDGRIIQVGVTSIVELVADVELSTRMRGVEKEVMWMAVGAVIQTHPHLARWLLESSVHGEQLVLSQFAPPPLLHATPPHLLPLRSHSTILLLTSLTSLVRTLTDFELIPAIWKVVQVYVLPEIETLPSGDALAQALGKLVFELEVLFYRVQPLHPGTAGDPFRVYTESHPANAAPAFLKHRDLIVRYTADGTLWKGPFVDAAKQVIKGASLVSACDMVEGFVRRKDMATLGRECAATLFSRHATSTHSAQPAFPLLSYLSQFHPQILYKPLFALSASTQPNSLLPSLRQVTTFTHILSPSKFWLTDPQMVTIVLMGDARPKVSKGKGKEGENAVRDVRLGRWAVGVEFILALKEIPEIEGKNIDDKKWKTFGDELEGRLAAFLEAEERDGSLPTGYRALICQVLWTLRLKTQSAKRAPWTKQLISWFNDTSRYLIPSEEVEATKYLRTVYRALSPETLSNDQSIGQPIILPFSSPHTSANSNHDARIKILTRSIEEILPSLLVLAHDSLSTQDWETILPFLWAWYGTKAAATREIGFMLEKCAEVIPAQLRSIIISDLTSLNAEVRCQVLHNISTLFAWRNQILSQPIFTSRRGPLFHFPTRTLEFVPTEIGSSEWVSPQDVQDTQLQKFGQTLPLELRQRLSELGWSDEDELKASSDWEQTPVSSLPGLAFQADGNLICRRNSARPSIPMRSLNRRGSSASAGSSSSKRRKAIFAPLFVNIVYDQMTILAGEVDGPISATSREVVRVLQRDDVVSFLRPITERMKDQFLNAMERLDRITKFLAPGFAYSAVNAIVGHLKSSLKTNADFDYWDIALASVVRLVPSVSEISLRDIRKNKAEHVLLPASIHEEDGGFKIHAPWRTGQRGVQTAQLLILNEILKANPREVYLVKKMLHNLQIQSSINHLPFSRAWLVLILTLFSFVNRNYNDRAELRHFLSNVGAILSLHGQNDLVIVAHAMRIFMLCSARFRRVFSFMGFPTIMRSVYETYAAGNAAIKDCIEYAAKSFYRIHEEVFVYQTCMVIASGSYDAKAVYAFLSSLSRERTVSSGLTSGIRGRNDKEEIDALVQMVSGPEITLAELGKEAAERHSTKLASITLEDKLFPRENIVRLFITAIASNPATTCSANLLRLLSILVPKLNDSVSKGLLSEGVEALGSVIIKGKTGDEAARSAFHPGANDDETDWTRARREYVFLVESFAKAGGHLGTSATRRTLDMVSELLSKQPESVGPSASSIVGELAKTRLTSGRPTPFLREIAPIFRRFISVVDFSGMLDSISTLIRLSNYNLDEEITHIIIHDYVEPVVKLLASASEDSLAFIVPLRSSAVKLLSVAVFLQGDALGVLERHHASASLLASVVMPLCLLLESPREVDRQDIYSSLWIRLLQYVLKGSIERSGRSPKLLSVSVYHPRSIAASNVLLVQIVKIVLIRAPDSISRVKGLWTYVAQRMLQIVDGGNARFMDSQRSLSPRVVDWLMWSVFELVALHPSALHIEFQARVHQALAMIDKQGTYSSLSSPASGPTLMTSTSQQYYPVRSRLSSNRPSSFIGHARSSSNVGLDQTPLASPDHSTTATLAVTPSRTKTDSNNSSPSHSPSLLPSPLVRPHGVGSEIEVIHSRTPSQGKMAGLSPAGAARPSFVALSARRASRPVFEALSSAYPTKGRFLSSANTHDLGSSSQEAGGAIIHLLGAPNQVLSATSSGFPTLPLANSSAINPTGPKVSTQVGETALRDVYIKSEELKQMASEAVRTVMLVYGWRSNNEEEAVVRNWSVLDALHIISKQTKVFVEEEFRDVFSPAADLYESDDGRIGSEKQEGVRSFRDRVRASGSLDKISIEETRRIMDEKERDVPIVSVSSPYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW46</accession>
    <name>A0ABR3BW46_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615237.1">
        <property type="nucleotide sequence ID" value="XM_066756460.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988767"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="259"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="701" mass="76046" checksum="1FF010786A388954" modified="2025-10-08" version="1">MLLRIRSRAGTARITVQPEMTGEEFAAVILNTIPRSDPQPDPATPALSNQPGTGGESVPFQALSGRTVGDMGFSHGDLLFLSYKPRGADPDSHPAMEATTSLSQPSQPDPSHPKTHTDPPLPNTIPLKDLSSVQEPEIDQYWEKQTGKIERKRDPAFCRHGEKAMCDYCMPLEPYDPKFQSEHQIKHLSYHAYLRKLLSSRPPTASSATDLPPLSPTSLSVITPCPTGAHPPFPNGICSTCQPSAVTLQSQPFRMVDHVEFASPSIIEGLLSAWRRTGTQRIAFLIGREDKYEKVPMGIKVIVEAVWEPKQEGELDGLTVETPWSDESRVQEIARWCDKGLSVVGMIYTDLTPSPDDITKTLYKRHAQSYTASSLEMLLSAAYQLSHPLSTRMSPTGHYSSRFVTCCLTGDKDGGVDILAWQASEHAEAMVKAGIVEASVDPTVVRVRKPGEGEYVPEVFYSFKNEYGLQVKMPAKPTFPVEYLYVNITHGFPLAPSPLFLSNAFPTENRPGLHDQSMQVVITQLAAILKSSDAEIGDTGTWPGRIKKDVERWLSDWHLVTFLCMQGLFSLKEQKILCRAATAHAHPNDTHALEELFASDGWQTLLTIVDSDVSTNGRSNPPPTSSFNNLGIDSPSFTGPSGGGSGTESSAPQSGPGSVGAGAAAGAGASASSRERICPHCTFVNEHGGSDCEICGLPLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW87</accession>
    <name>A0ABR3BW87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615355.1">
        <property type="nucleotide sequence ID" value="XM_066756578.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988885"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01849">
        <property type="entry name" value="YlqF_related_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanine nucleotide-binding protein-like 3 N-terminal" evidence="7">
        <location>
            <begin position="14"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="263"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="509"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="71073" checksum="C535759EE8D39DF5" modified="2025-10-08" version="1">MPRIRKKTSNRQNTRDRAKITKKAAEQKRKNKKASKKDQTWKSKKKADPGVPNSFPFKDQVLAEIAEEKRKSEEDKIARREAAKTQKSNGAEDEADTPGVSSLGRTVLDRVPLTATSSIVATPSEDLDVPELIDTALPTLQEALDRADVICEVVDARDVLGGRNGYIERLVKEAEGRIILIINKIDLVPREVLQSWVSQLDIPTFLFKSALPLPPTPSSSRDPGPSFFIEPFVVLGREQLIAAAKKWSAEKKKSRKSDEPLVLALMGLPSVGKTSILNSLLPSTANKSRHVVAPLIPSAQSAKSLQPTTKAPVEVEIDVDGLKIKVIDTPGWDPVEDEKDEDEDEDEQDPEKWDKLEAKLSGDLLRRNLGRVDRVKDVFPLVNYIVQRSNHQDLMLAYNIPFFEKGDLEAFLTGLARAQQRIRKHGEPDLEGAARVLLRDWAHNTFPYYSLPSSISASDMDVDASSAADKYDMTEILKKCRGKKEMKKESNKGMIRFKGGEIDEREIILDDDYTAMMTSDDEEETDDEEEIDDEEEIDEEEEDEDEGSVSDEEPFIIGSDEGEVLELSEGTEPESESSPEPEPRLPSPSSSKPKKRRISEASVAPAKKAKRVSFARNIPDGKEERNIRGGKKGKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWC6</accession>
    <name>A0ABR3BWC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614595.1">
        <property type="nucleotide sequence ID" value="XM_066757126.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989438"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="225"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="387" mass="43990" checksum="AA6F9C7D35EE442F" modified="2025-10-08" version="1">MPLHNPIWEVIEPHLVRYNLYTVKDPTYGRYLLPHHPPHLDLVNDPSVSHNYRRVFLRPFNSFRSYHEAYDTTQIIHAEDISLTPEELDSGVKHGGRWVAYSTWEMHEPPEGGWEGGGRGKGRDLVLVHGLSDYGLRYAPHIKHFLKAGFRVIIPDLPSYGRSTGGSSMGGWTVLYYLLKYPPTAQSEKVASQASKPDIAPPEEGFGQGYDRLERSRRDEKVRIHVAGAFVLCPMIEVSKESRPNILLEYIGRGVNSFAGSLPLAKAVRGNVSDDPRVEEDFFADPLCYHGMLRVGTGLACLEGMIELQERAEEIDVPIRLVHGNKDRATSHKGTLRLFDRLPNEDKEIEIYDGYEHVMLKLGVDAVDDEKRQRVLADWRSWLVQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWI0</accession>
    <name>A0ABR3BWI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615219.1">
        <property type="nucleotide sequence ID" value="XM_066756442.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988749"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="685"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="749"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="88429" checksum="36B72539B424F915" modified="2025-10-08" version="1">MWALRTSSPVVRPPALTLLRSVSPLLFARAYSKPAERAGSRGGHSRTSLATAKGNTPSQPNHFERHHTPYSRKSKVSSYNTRPSSRPFRSNQNDDNPWTTSVRLRRWIERHKTPLTPAQVDEVTRLVIEAPQHMLNAPVWNMLIGYMGRLGKLDRVWNLYNQMKKRNFTPTARTYSTILNAYAGVAHSGQTPDFSFKEPQKRTMSRVTIVYNHSQEYMKKLIEAQGTEEEEDLGVSTSGVQLREDRPQESTESLQQSDIVIAPTNAYLKFLSRHGLFTQMQRTFLSLPQSGPLAPDTVTYSLMFAALYHVHRSLEHAPDGKAKAMMIGPTAKALWEQCLRQSSKKEGQGGQVDNGLVAMYVRCLLRGRPEDQRLAVSVIEQVWNLPSPGNSDPTSTSIYLPPPLLTAYPIPKLDIDVKSATALISSLHTANLPVLATHYTHLILSSSSLIPSFDIEFFKAAILALSATGEVQSIVGIMDTYQPPSRGKDGWPRDTYRAALTAARWAGDYVSALSIFRRATHLSFNVGHISTDPSTPPPKIEPYRWVTPNGLAHDKRDTVWVKPTKIDPDAQLLGLLIKTAIQKSNKEIRSALDVYVRTGGESKYLALPSAMQADNVSTTSRKLLRDEQSRELDSSAMRKQLTSSVDLARDIQRAAERLGKGYEKMAVEAGEVVTKWGWVERGARKKTPHVKGDTKNVEMDIEGSAEDEDLDWEDENLVGTRESRVKGTNQDRHHSTGKRRRERRGTSKSHPDSTGHRKYVHERGSNKAKSREREGTMREGKVSTFGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWL8</accession>
    <name>A0ABR3BWL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Las1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615503.1">
        <property type="nucleotide sequence ID" value="XM_066756726.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989033"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0252783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="52761" checksum="58B64CEFEF9E4979" modified="2025-10-08" version="1">MKTPRRVPWTSQAELTELYGMLFSPAADLESRRRGLARMSIYISSPSCPSFIHLLHSLVAAELLPFPPPRGAEESQRMRMMMGMAIVRFVNGMVDPLQTGPYARPISHLAATLGLPPSLIALRHRATHEDLPPLPLLHQAVTQCIIYLHQNSFIPLITSSYGSPPPAVLERQQAAAKRVDGLLKKWKKIAKNRLRDKEVREEDESAIEMKKVRKELEGEVAGASGIVRGLVEVGSLVPLAKRKRASQKAISPPPPSLSIWEPLLTHLSNTTMPDLSSVLSTQIIDILLNPSTSSVQSQGPQGFNPSADLISLNEDERDASGESESYRWGLAVWLLYFWRNNLSENPLKLTEEERKAIYRRLALILLHKYDDPILTRLHKSLAELDESLRDIADDLPILPKTDVRNIADGDIEVDVIESRLQAMEKRLVELEDRSVPAQVADADAAPFTESASLPGWRRLTPQEWTPCPIGTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWN9</accession>
    <name>A0ABR3BWN9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="3">HMG-CoA synthase</shortName>
            <ecNumber evidence="3">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615523.1">
        <property type="nucleotide sequence ID" value="XM_066756746.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989053"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="5">
        <location>
            <begin position="185"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="5">
        <location>
            <begin position="286"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="566" mass="61574" checksum="26E1FE7044AE06A9" modified="2025-10-08" version="1">MTHFDIPSRPSNVGIHAIEMYFPKRCISEDELEDFDGVSKGKYTLGLGQKYMAFTDDKEDINSLALTVVSNLLKKYNIDPRSIGRLDVGTETIIDKSKSTKTLLMDLFAASGNTDIEGIDSKNACYGSTAALFNTVNWIQSESWDGRNAIVMCGDIAIYKEGSARPVGGMGACAMLIGPDAPLVLEPVHGTYIANTWDFYKPDLTAEYPTVDGPWTIAAYLGALDNAYSTYIDKAEKSRARAAKKLSLSNVSAKASEIADAADKFVSGINGDIEGAAVNGSGHANGENKDRGIAAFDYVCLHSPYGKLVQKGHARLFYNDYLRNPSSPLFANVPESVQSLDKTKTYTDKTVEKAFIGVAAEHYKSAVVPGSDCVARCGNMYTASLYGALASVIASSPEGIEVGKRIGMYAFGSGCAASFFALRVAGSTKEIAEKMRLKERLASMDVRPCQEYVDALKLREENHNAVKYTPQGSLDNIWPDAYYLEGVDELYRRTYLQKLQHLFVLAPSSTNVSTGPSRYIHSAHTCTPWPGDNLLHNQPSLPGMTLPMPISTPATLTSTTAQHWHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWP2</accession>
    <name>A0ABR3BWP2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615020.1">
        <property type="nucleotide sequence ID" value="XM_066756243.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988547"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="410"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="922"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="922"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0252300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1120" mass="123571" checksum="EB4EA67AD19249BC" modified="2025-10-08" version="1">MSTKGFSVGPVHYPSAPGFPLPQSPSSSFRSNHIPSYSIPPPPVPDFSGQVSNKGLYTPSIAPSVTGTSTGTALGSASGSRRMRREKEANGRSTDNKEDWAEIEPDEVFRRLQVREVKRVETKMRSEALNKQSELRAMVGARYRDLLTSATQITSLRSSSLRLSENLKQIVQSCQNPELAAENDAEDDSVQSQGEEFVQMLPAASHMKLLLDAPEALYAYLSHGAYLSAAFLWLIARVVKEGLVNMPEDASGLYLPLMQKQWETITPLRNQISQRAASSLRVWEKAEPRTTCETLLSAILLDNLPLSEALTLLLSQRSKALREILHHPPPSQTSNKTRATAGSRAQPPNATRESITRTLLDALRCMLETSSTAHLIFDKRKVTEDNGKANENGESMLDEMIRLVQKGEAVPTATTTASHPIPHKRNSGSSTTADTHQRRTSRLVSISLPMPPATSTSALSRPPVSTPEILSHLPASQILLRHLPTEITGFTPFITVSAPPHLSEALKTWQAECVGVLKAALPAWLEGLKNVSDVWYVRGSLIDLLEKQKQAQVSTPGEKERMVQDELEEEWSRRIKAIWDEKLSGVVNDVERLVKEGAKKVYRKDDEKHPEGLLFTDLALPFENTSFILSSASSISDSPLSTSVATNLNKTDPFATFRAAIQKRVARRTPVLDETLSFLEASAKSIKQDNLLYSSPSASSCSAGKGLSEELYRAYGEKVKGILDELVEKLDAVLGNVEEIVSAAAAEGGGEDQGKGREKEKEVEGEVYVGRVALYLAKKSTFLQDLSGVNLPGAISYMDDNVVSALLEIHTKSTKKWKAAAVREALKKLNPLFSEYRGSQEIRANWQGAYPTTPSGEIMVALQTLCDASKALGIPPSSFSSGKSEEIKKEGGVVEDSVKGFVREVRELKGWERMLIWKGEGDKSEQMEEIREGKEEEKMNDKGQETETEEQEKKEEKEENIQRKEKDEKEESQFRLRRPSTQPSEGPEALLQSILDLSFLNLIANEPDHSSILVSKIPAEHVEFKEKLHIILGESLKRVQLLIYALVAHLPASAISSSSEPSTTRSEARVGYHHNSYDNNRNLLRFGPPENNKPGATAEFRSPLVVAKPGKRMGLLNIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX03</accession>
    <name>A0ABR3BX03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerate-and formate-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615637.1">
        <property type="nucleotide sequence ID" value="XM_066756860.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989168"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF129">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE C1773.17C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="82"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="130"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38098" checksum="150B7CA58A1C2421" modified="2025-10-08" version="1">MPVAVSPRRKILGIGYPRFAIPEWKELAEKYDIHYFIPDERKQVIREIKRLCDEQGPFDAAYVLFGTAAYSPFHPDLLGPLIDKPGYCGLFAQGGAGYDDVDHEWLAANGCYLSNTPNAVTEATADMGILLMLAAIRGLYEAEVSVRAGQWRKGIELTDDPTEMTIGFIGLGAIGKSMAKKTKPWNMKILYHNRKPLPKEEEQSLGATFVSLDELLAQSDVISLNCPLTPETRGILSDKEFQKMKDGVYIVNTARGAVIHEPALIRALKSGKVRRAGLDVLTNEPCAESPLYSMKNVTLQPHLGAFTKGTMLRGELEVFANVKQYMETGVPVNPVNTPASIEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX09</accession>
    <name>A0ABR3BX09_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615552.1">
        <property type="nucleotide sequence ID" value="XM_066756775.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989082"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="271" mass="29586" checksum="D1A293943F2BBF32" modified="2025-10-08" version="1">MLSITRHVRSSCRTTPVFPNRFLSTSPSVSNSATKPQDVLKGTEHDGSSNKIETWFLSSPSSPAAKTKTQEPGFTPLTAPPLPSHVPLAVHQFHGFITAPAPSEASEVVLPHTLEFFDTRSASAALEASAVPESLPQGWESAVKVSGLLGQNVRNVVNKEEVVLPEGDLIQGLEGSGPAWEWVGVVQVRGRGRGVVRRADGVVRRWLLKNPLSPSVEPVTIENPKTPRIDPDADWSIVPVKGTRICLNILTEKGRERWRLEDLWGARDHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX64</accession>
    <name>A0ABR3BX64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1753-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614880.1">
        <property type="nucleotide sequence ID" value="XM_066757411.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989732"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29888" checksum="C1C479590ABB2C51" modified="2025-10-08" version="1">MRINFSPQRAAIFTSFLGLLDIKLGAEIILLFGLINKVAGLYGLITIFVGGSFAQLLYYAYSVGTLFAFLWGLRVVKSESSGPTLLLSHLYSLDHIIVSLFHYIFYLHYWYTVPHDGRRTINSQAQQDLINLALSRGEITEPTGESGQSADELRTALAGEIWERERGFAVWTLLAGWILKIYFILVLYSYAAHLASSTYHTLPLTFRGKATKLAHPDPGQEGSSPRIPGESEDDIELRRAEQAARDGPSKKGKGKRTEEDDEDLSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXN1</accession>
    <name>A0ABR3BXN1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615026.1">
        <property type="nucleotide sequence ID" value="XM_066756249.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988553"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045562074" description="Glycosyltransferase 61 catalytic domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="9">
        <location>
            <begin position="202"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="462" mass="52781" checksum="27114D087119E458" modified="2025-10-08" version="1">MRAALTLFFTVRLLSTALAASVLPSQALSHGPTTLIRGLPGFTVLDNVWYRNRTFYVLEDESEIPQTDRLLSLSQSSSGIQSVERVNWREMAFYDGEDNSPKGIQAKPDVEIEELHGITLFFNDGWDGKWSGYKWLYHMVAEALLGSLSVLSSVPPLPTSIQSQRQDQNQAMRQGWVTYGGDGKLPDRLVIAWDHNWDDRYGLPRAVAEALFGDDNLIEPEQWTQMASQDTWIYFERVLLVDRDTAHRHNPLTHQWLKMAVDAYRLASSPSFFFPTRHALLSHYDIPTYTRSAPGLRLSGRKPKIVYVDRQRTERKFDTDVHKQLLTRLKKIEKAKKAVVVDAVLEDLEKKEQFEMFSDADIILGIHGNGLSHELWMPEGGIIIEILPPTSFHYDYPPVSAALGHEHIIWQYDKLFSRDKWIPENTKKNGSLIHDGSLIPLDVDSFTKLVEALVDSMSFSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ76</accession>
    <name>A0ABR3BZ76_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615891.1">
        <property type="nucleotide sequence ID" value="XM_066755605.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987904"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="513"/>
        </location>
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            <begin position="554"/>
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            <begin position="1400"/>
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            <begin position="1"/>
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            <begin position="85"/>
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        </location>
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            <begin position="115"/>
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        </location>
    </feature>
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            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
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            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
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            <begin position="729"/>
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        </location>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZF9</accession>
    <name>A0ABR3BZF9_9TREE</name>
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    </gene>
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            <taxon>Tremellomycetes</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10718" checksum="F3F5E1EFECEB65C0" modified="2025-10-08" version="1">MILIIINLASLRFCFISQLGFGNKLHAAFVCITRFNQPIFCRSFPSCLLPTPACWFTQRTGFKSTAVTLCCTITSNQFFHNSFLDYSVFREFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C069</accession>
    <name>A0ABR3C069_9TREE</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
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        <name type="scientific">Cryptococcus tetragattii IND107</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254028.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066755963.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046420837" evidence="3">
        <location>
            <begin position="26"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
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        <location>
            <begin position="177"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="274" mass="26297" checksum="AA154FAE5AB4718B" modified="2025-10-08" version="1">MIFDKFSLIVALFLAIFDMADRAQAAPQPAGLVGDILAGSFNDGITVTANGVVQCGYANISWTGASLPVTVEIGQGGYYIAGGCRFNLPGGRCVGEDGNSASNSSLTASSGSTGSATATSYSAAISEAVGGTSETASVTPISASTDASDPVSPSPSADTTKSDEVSATSAVTSQIQAPAAASSSTSPSASAASSSADSSSSPTSSSSPTSSSSPTASSSPTTSSDGNSASLAAANNDSTASGSSSSTSSSGTFPGMFISGVSVIFAAVGTFAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C074</accession>
    <name>A0ABR3C074_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hepatocellular carcinoma-associated antigen 59</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101416</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616258.1">
        <property type="nucleotide sequence ID" value="XM_066755972.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988274"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0254037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34249" checksum="FC6BFFD2A2ED4834" modified="2025-10-08" version="1">MFKKRSRPTSVRGKSRIEESEGSGNEEKVASGSGTPVEEQEDDTGRTVEELLMLKKLKKAQSKQGIDLEKLNRGEEKKSKGKKKDEDAATKYGLQSGRGMGRGDGEKKKDEEMEDEDERAKRLVRVNNFTQQTNALDVDKHMMAYIESELAKHRGQAAAPTDKPTVEDNDPQAELYRIAEKYQFETKKKKADDEGNVTNSLGMLTSIPEVDLGMDNRLKNIEMTEKAKRDMLEQRKQEAAAAAAAAKEAEDPGYAAARFYRPNQKSASDIYANYEKRQTTGVPRQESATDEQVYERFKKRMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0F4</accession>
    <name>A0ABR3C0F4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616097.1">
        <property type="nucleotide sequence ID" value="XM_066755811.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988112"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="397" mass="42885" checksum="4A88FED1824E705C" modified="2025-10-08" version="1">MSSFSDTSSASALPVTPSSSRRVPSPVVTASSSSLATHDLSTPVSLGPYITPPPSLRLYSSALKAKMAAGMTAAMRELKDDRGRPERKLDVEFGYDEDPIERHVKLFLTPRTATRPDRPRPSLSHPSAISTIRPVSAPSAVKSAKLRVTDDGYDVNVTVDYTERTGHALEESNTEMLAASPSTVGQSSASIRDRDSFVPGLIKFHRAHPTSSSLMPHRPDAWRTDSTGSTASSIASEASFEAIKAEDMVSLYGGGAGVKRAEGPFDEETYWGDESEWGFSRASMLSTSTNETVRPAKTPKRTPTSTVHTSSPAATLACSLLPRAKLSPALYQRLPPRRPGCSQQIGAGSDDGRSADGLGDLSMENDPIWLKERTLSEKMVLQAGLRSQRQRVEIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0I2</accession>
    <name>A0ABR3C0I2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_101512</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616353.1">
        <property type="nucleotide sequence ID" value="XM_066756067.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988370"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="456"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="772"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="814"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="820"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0254132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="965" mass="106670" checksum="0C0B5A0545B6B79F" modified="2025-10-08" version="1">MSSPPSNFNFPSSSAPMGSPRRSSPPGNRPIVDPLAFENVHGLAGSLPGARNGNSDASEAEEEGAIQGGRGRRQGRRGVELDAIPRVKDTTGEKVMESFILFLENYTEIIAFPETPGSVVPPPSGDESKYYVEQIHLMKIDERTTLYVDFGHLLEREEILAQAIQSQYYRFLPYLRRAVQFLVRRYEPTWLYMSTSVNASETIPSSSLTTREFNVAFYNLPITSGIRDLRMDKIGQLMSISGTVTRTSEVRPELVSGTFVCDNCKTAIHDVEQQFKYTEPIMCQNSICGNRNQWQLNIEQSKFSDWQKVRIQENANEIPTGSMPRSLDVILRSEIVERAKAGDKCTFTGTFIVVPDVSQLGLPGVNAEMMREAKGGRGDGGPAGQGVTGLKALGVRDLQYKTAFLACMVQNADSRAGVTDVRGEVEDGQEDRESFLRSLTSQELDELRGMLSSDSIYQSLVQSIAPTVYGHEIVKKGILLQLMGGVHKQTQEGIHLRGDINVCIVGDPSTSKSQFLKYVCGFLPRAVYTSGKASSAAGLTAAVVRDEESGEFTIEAGALMLADNGICAIDEFDKMDIADQVAIHEAMEQQTISIAKAGIQATLNARTSILAAANPVGGRYNRKMSLRQNVAMSAPIMSRFDLFFVVLDECNENVDLHIAQHIVNVHRFRDDAIAPEFSTEALQRYIRYARTFSPKLTPAASAVLVEKYRSLRQDEGGPGKSSFRITVRQLESMIRLSEAIARANCQHEITPAIVREAYSLLRQSIIHVEQDDISFDDEDEGNAPNGLDGPGGPGHDEMDEDPQLSSADIAALDEAESSYQRTSSAQQQEQQAREASVATTQPSKRKMRITYNQYMEIMNLCVLYLSEVERDSGTGVDREELIQWYLEQKENDFESEADMEYEKELIGKALTKLAKDSYLLEIRGDVREGLVPSSELESSAGDSNKVYYLVHPQVDLSDLSSSIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0U9</accession>
    <name>A0ABR3C0U9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616265.1">
        <property type="nucleotide sequence ID" value="XM_066755979.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988281"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF2">
        <property type="entry name" value="FE-REGULATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0254044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="495" mass="54130" checksum="5E08E4CB648E255E" modified="2025-10-08" version="1">MPQSSMRTVVVLGASYGGCHASKMLAEELPPNWRLIAIDRNSHFNHVYAFPRFTVKSQHAPKGFIPYKRMLDPQPKKSSDPLTPPQTPPVESATLSDEFSARSRHQFIQACVTKLTSREVTFVRPTHQAGSSISTAGNMAYGEFDGAEETIKFDYLLYALGSTLPDPVNVWQPIDEGAIGEQRKPGTKKRGLRFMELQEEKFKQADRILIVGGGALGIEFASDLKDLYPEKKITLLHSRTRVMPLYPLELHTIIIEALKKMGVEVVLGERVMTWPDEPETLDGKTKYVTTDKGRTFEADIVLPCTGQKPHVSLMAEVNPALISPTTSRIRVLPTQQVHPGPIPPAKVETAADQLAQLSLGPAPFTPPSSDVGSFEASSGTGRSEVAQEEDYSHIFAIGDCAETKAIQAGHTAYWMGEVAARNILRLIAKQEGGEKKDESLENYEPGAPAIKITLGINNAVVANGDGVTTNNDGVEDMHSLVMWPTCNAEGMDVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C2K0</accession>
    <name>A0ABR3C2K0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_101140</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615985.1">
        <property type="nucleotide sequence ID" value="XM_066755699.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987998"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="919"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="16">
        <location>
            <begin position="312"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="15">
        <location>
            <begin position="488"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="754"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="799"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="806"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="853"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0253764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="974" mass="108606" checksum="CD9F245CDF3A9448" modified="2025-10-08" version="1">MSIFPTTSSPFGLLEPIHTYILSNTEQLSWSNWWKLFVIPFIPLYLQVLLLRREHTRKERVALAVLGLGLLWHAGLRYRFLQPWFNAFNNGLGIGYMTISLRYLEFAFIEGRLVDEYWESRGRHWSVAAFDICINARWLGLGPEGLTQTGSSPKVNYSVDSYSPNNSHSPSNGRIVANGGAIKRQSQTYPAWVVKPPLRLSRSQAVLRHFIIFFRNYTICDTMLSLLRAYGSDTIGSSTPVPHALYQFSHKNAFIVFPKVAGGFIAPRWLADLAAVICVAICVWLALSMAYHFLAAIAVGTGLYEAEAWEVDLFDDPLAADSLLDFWGRRWHQFFRHQFLMLSTFILRALGLPVSSPSILFLSFFFSGTMHTLGQYLMDPVPALLPVFALFLLSGFGCALEVMFKRITGRKVKGFWGRVWTWAWMLTTGRWAANAWFESGVGGSYLCPAYIGEWLSPRDSPSSPSCEEEQTMNSQPPPGDPNLTLKVLSFNVWGLAIVSKDRRTRIQAIAEYLASSSYDIVCLQELWIYKDYEVVREEVQGNLPFSRFFHTGALGSGLAIFTRFPLIAAHALPYSLSGSPAQAFAGDFFVKKAAGNVVILHPVLGEVEIWNTHMHAAGEHPPDTRQAHRIAQSWQLANAVRGGAAKGRYAFVMGDFNSQPWSIPIAMMRDHAHLTDSFAQVHLSANSEISPPPSPAEALKVYGMTCDSPLNTYSAGKPIPENVLERGGKRLDYIFFRQPAVARRRPLLWKYKDEADGEESQGGKDRSGQGYIESGKPLQDSVSNHFALFSTFAIDAPDKGKHARNASPQDEPSKLSHSNSSEPLMPIVSQSKADPIGSNVYAVRDPFKRHSHSSNPSSPRTSTSSIPKASTIRSALGTLRLYTRISSHTSTSHLRICGLSFLALIGLTVGSAWQPKSWLQPIFTILAGLLGAAAVTFLYTGFIWGRWEVGLLTEVTEEMELELRVVEMEENVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3M0</accession>
    <name>A0ABR3C3M0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616510.1">
        <property type="nucleotide sequence ID" value="XM_066754609.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986887"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF14">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045988000" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="190"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="427" mass="44529" checksum="9EF530CE8CD1030F" modified="2025-10-08" version="1">MQIGSLVPLLALLAAPAFARSSVHPNAAAHRRQDVAHERVNSAVERREALAETQPRALAEKPKFKKITRRGARGCRAKNSTATASDSATASAPSGNSTVVASNSTDTNVTSTVTTQSPVGNTSSSSESAAATASSIENLAALQQPSSSSSTGDSSTAASSTSVASAAATASSSSNSTGSYTPNGIKAGISGDDPLSFLQGHIGWYYDWNASPSGSASGASPANMLWGAGSVDSTDASRLAAFKALTSTPEYIIGFEEPDCSTPGSSNIAVADAASLWDSTIAPWKAKGSTLISPSMCHQAAEQYTQWLAGFSGQISTSWDITNLHINKNSMDGVKADIDYYYTTYGKPIWVTEFACVDDSTGFVPCTDQSEINTFINDIVDLFESDDRIQAYAYSTGEGLSSQWDMISNGALTESGQTYLSAISKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3T3</accession>
    <name>A0ABR3C3T3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Catalase</fullName>
            <ecNumber evidence="8">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_100085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="8"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616565.1">
        <property type="nucleotide sequence ID" value="XM_066754664.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986943"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF62">
        <property type="entry name" value="CATALASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="11">
        <location>
            <begin position="176"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0255288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="701" mass="77556" checksum="56FA010080B72C5C" modified="2025-10-08" version="1">MSARNLAAGTPYRRNLSPANGSHFDAPPVSSTSDSADSTNSVGYTPVPTGERSYSGLLHGTISKVFRKGGQETVAPEEPTPFSSSKADSDSARFNGCPYMNGSIPQTPTPKSTPKSASVAAPIPLPPPSAARLKGQKQNGSIPQMNGNSLADDVGKLTVRSYEKDRDLKSQEVVYTTSNGVPVPHPYATQRAGVNGPLLLQDFHLIDLLSHFDRERIPERVVHAKGSGAHGIWECTDGLEDLCLASMFQRGATCPLTIRFSTVGGESGSPDLARDPRGFAVKFRTAEGNWDFVANNTPVFFLRDPAKFPHFIHTQKRDPATHLGGGDDSTMFWDYLSQNPESIHQLMILMSDRGIPAGWRHMHGYYGHTLKIVNDNGDWVYVQFHLISDQGNKFFTSEEASTKSPDWGQKDLYEAIERGEYPSWTMKVQVMTQEQAEEAWERKRINVFDLTHVWPHADYPLRTVGKVTLNSNPSNYFAEVEQATFNPAHMIPGVEPSADPVLQARLFSYPDAHRHRVGPNYQQLPVNQSATPYATGNFQRDGAMAFYNQGGRPAYLSSIEPIKFQERRVNLNKVHGQFIGEAVSYLSEIRPEDFNAPRALWQKVFSDESKERFIQTVAGHMSTCRRKEIIARQIAIFRQVSPDLGARLEKATGVRGYGSIEGMSFNGTHNGFGIKRGANGLRQDAEAVFNNGAPQKTQKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C404</accession>
    <name>A0ABR3C404_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616634.1">
        <property type="nucleotide sequence ID" value="XM_066754733.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987017"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="47840" checksum="EFAA1556CDEB5C86" modified="2025-10-08" version="1">MEGSQDVTDQTAQPTFEIVVLGSGGGPLETDCAGYLVKAIGQRWEDGILGLEGGSGLGALSTLFSSQSSDTMFPDITFPTDYNTPLLQASYVFSFVSGYLITHAHLDHVQSLIMLTGSAPSRPNLIAPKYPSVSQPLPPLCPIVYGTTGTLEKLSTAYTGEIWPELVAWIGERSEDRKTEAPNKRRKANQSDRSTKSKFPESDTRLPRSKHSSASLVLSPLQTNSPPQLLTGVPSLGVRLYPLVHGCTSKETYESSGAFIRHLPLPYLPPKTARRVRSRRKPMEGKEFLFLGDMESAYRNTGENGTHQELRAKASRLNSTIWEEAASSWIEGRLCGIFIECSYDSSRLGRHMYGHLSPPAVYHELKVLAGLVSQTKTRPLDGLKIFITHIKESLVPHPEGKTQHEIIMAQLQELEKDGKLGVVFIRPAKGDRIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C426</accession>
    <name>A0ABR3C426_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616660.1">
        <property type="nucleotide sequence ID" value="XM_066754759.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987045"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="62050" checksum="A456A94D48A24963" modified="2025-10-08" version="1">MVEEYLEVPGTARIYALDGEGGEGGNTSSLGITLIPTPSKDPDDPLNWSKGRKYLMLACVALYTISVTILSSDLYSVFDPLSASTGLSLDQLNVGTGYLYLFIGISTLISQPCSTAFGKKPTYLVSAFGAALVNLWTAFARGNGQWIASRLLLGFFISPSFTLVEFFLHERSFPIGLYFVVLFMGVSLGPILSGYIYEGIGWKAIIWLSSGLMVIVGFVLFFFLEETSFQREHLTNVDEENNESVTSIGLSPPQGCTAVQALSSLENNNGENPDKKGSLADTTTYYVEPTVTNITPFVSTPWPGPKFWKYAKPHKHAAGILMRGLVQPFLLLRLPLIWWSGLMFATYQICFNLIAAISSGILVEPPYSFSTSQVGLSFLSPFISAIPGAAFGGYFTDSFVLRQAKKNHGIAEAEHKLKLYIIPTILTPIGLLMMGLGPYYGVHWIVYILGCFIVNLVGPVAAILTVAYAFDCFHPIRPKDEHGVQACAQDAAPYLLSTILLAMCFTFGFNYAITPWCFGWGLRNFAISSAIIITMINATVLIVIRWGKKMRKSQEAYYRKVINW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4F5</accession>
    <name>A0ABR3C4F5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear pore complex protein Nup155</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616786.1">
        <property type="nucleotide sequence ID" value="XM_066754885.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987171"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="7">
        <location>
            <begin position="186"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="6">
        <location>
            <begin position="675"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1326" mass="146209" checksum="D1D56033DA0775B5" modified="2025-10-08" version="1">MLSSLPSLSRLSHVADSSHSQQANQYPTQIMPSSNQVQPYVPGQVGAPQQGLYPQLPGTQPYPQTSYNPYGGSAPGLGTVGAQIPQGQPLSQPFGPSSGAVGQPYPSQPVAQWNRYLTPLQAPQSLESVSKDEDPIYGPLERARGKIDRGLRGDVDISGDLEEKLGPTAQIQDPYAAPPSASAAYKCCSVTKRTPLPDALHQELNFKHLTAKMGLFEEIERAWFTVDNKLFLWDYGDGRDFSRYDEQTNTIQAVGLVKARKDVFVDDITHVLVICTSTKATLLGLSRSSTSREILLYHTNLTVDTPTVMVDIKGTDEGRIFVLGANKDLYELDYSSDSSWLFGSSTSVRLKNRTSGGVSNWVPSVVASKVKAGIESFAVDSQQKRLYTLHTGGEIEFYDVSANRFDLRSKYNRLKHDLNRDPKSGAVTVVSISAIGGHESKRACLVAIASNGVRAYFVSTPSFYPIILRAPPPLQPGLPVSDQSIYTSGTFIAVQYDPNAPLTQTHLTFAIPQSGRQSALRENYETLEPPVFQEWTATEIVPSQVWTIVEMSDADPKNSPASLRRSDGLALSSLPRQAEAGPRGYLVLAASGLFWVDQPRPVDMLKANLDIEKDVAVNTIRMTFGKTQLASMALLLGSTPETKHPDLLSSLSTILLTSGEPVVKDSTGGKTITYSSRHDGLALTIARYLRPIWSAKVTLPLVGGKQILGIKETALSKVQADLESLRRYLEEHPFQSYQVEGEAKIAWAQEEMSLHGLNILLKQAVEAISFVLLLSDYKITDIVAKCDPTTQSALAGLTFESLITSFDGRAVARKLVTALIEQQIGQELGIDTLSEILQQRCGTFIQPGDVVQYKAEESMRRAETTRDPLEKTESLAESLRLFTRAAGSIPIPRLQEVSERYRALNYTLGAIELALRTASDLDPHKKAIDFVRDGEHPADPRKALFEARKECYAEVIKALKVADDWLDKAVAEGDAATATQSRNEAYALAIASDDELFHFYLYDWHVERGLQEQLLEFDTPFIEDYLKITISNVEDRRDLLWKFYARREQYLPAAEALANLATRPSPMPLHDRLYYLAQALTSAKSAASLGSEDVEFTSRLQEQIDVAQVQMEVARAVEVHPEMTGEEKLGVLAGLNDGLLQLDELYQNYARPFRLYEPILLILKTADTRVDDVCEAVWRQLLGTAGKIGGAAGVSEIVKRLGRRYFPSEAAPMDIMIPVVYAEAAGYPGSLGWASTTLLDAGVPLRDLWEAVTGLYENSDDEEREFYAEQISILAQRWMSQMDEIPAAEIERFASAYILRTNGASDDSTRAIRDKLLAAKQVAVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4U5</accession>
    <name>A0ABR3C4U5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616918.1">
        <property type="nucleotide sequence ID" value="XM_066755017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987304"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="66" mass="7432" checksum="B33F76BF023725E6" modified="2025-10-08" version="1">MSSASSYYGHCPVSSLISKHGTVRNTPREEQASADDDYRQILARDLRESRRDLLCTLRPASLFCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C559</accession>
    <name>A0ABR3C559_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_100560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617030.1">
        <property type="nucleotide sequence ID" value="XM_066755129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987418"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="57"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0255753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="223" mass="25220" checksum="9D301E36B5A60F5F" modified="2025-10-08" version="1">MATSKIRSSNASSPAILAPHLPVTDKLPNGQRYTICLVSPSSLTLQSQDVLYRLLDDNMRNLQSNSSFPYTEISKKEEMFDPTSRFLLALGGTPSGTSDKGPPGKWQFDIQEHELLGFCEFRFDVEETLSDKLAEVVYCYELQLKPSVQKQGMAKKLIGILEDIGRLRNMEKIMLTCLKNNASALSFYRHQGFEADEIDPTRISEEEPKYDEEVDYVILSKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5E3</accession>
    <name>A0ABR3C5E3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616667.1">
        <property type="nucleotide sequence ID" value="XM_066754766.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987052"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26108" checksum="D5A6CE41E082AC86" modified="2025-10-08" version="1">MSRGGWRGGRGGGRGGMPPGVGFGYGQISQTEWKEGINRIKAQSQTNGTLYPPLDNISISYLTGPTDHESLVLSHAISLDTTLSTGRLPECEEGVQLVQPGQIPPWRIAGERKVVGIEIESYSDRFNPPAPSGPSKLDPVALRMDQSMFPPSLWAAYFDGQTDRLKDRPKKKRKLDDLEQEGEDKVEEESEISEEEDFDFDDDESDHQDYDANYFDNGEGDDDEGGDDEGGDVYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6I4</accession>
    <name>A0ABR3C6I4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">30S small subunit ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616658.1">
        <property type="nucleotide sequence ID" value="XM_066754757.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987043"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15380" checksum="07C0E7445BFFC4DD" modified="2025-10-08" version="1">MHLLGHNLPDHKPLKQLELAPPGGKVLKPVGHPAIFGGLNKGKGKGQEDPLDDLKIETEKRRAMQADIAHLRMVGTYRGRRHAAGYPVHGQRTQTNAKTAKKHNRVERRNFGIQSLTRFTPTDLPQPPTVLSLLGRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C8N8</accession>
    <name>A0ABR3C8N8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617111.1">
        <property type="nucleotide sequence ID" value="XM_066755210.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987501"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047859">
        <property type="entry name" value="Ribosomal_bL17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="318" mass="34944" checksum="8F01FDB1366B5879" modified="2025-10-08" version="1">MKHGIHQRKLGRMPAHRIALLRNLVSALLHHESIKTTLPKAKEAAKMAEKIITLGKKGTNQARTKATAYLMPAHHAPSSSYIPSASNPTPTLPPLAHPQSLDPETFTPPTSLLPKLFTTLANRYAARPGGYTRIHKFGRRPGDNAPHAILTLVDGPRDLKFEMTARTVGKESLDAMDEWERIESSVDEWEGLSEKSKRDVAKVLRYRSEDDRKLFKAKATEFSDIVTVEDSAYGGVRKPALELQKPTFRAPSLNQPRSGKHVHAGERLSGMSVTHTGLGLARGALTRGKGLDRTPLLWGQSNRLNVVKGEVVTSNADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHM4</accession>
    <name>A0ABR3BHM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610716.1">
        <property type="nucleotide sequence ID" value="XM_066761176.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993610"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="31159" checksum="371736CCBF4B5CE8" modified="2025-10-08" version="1">MPAARLRLENKVAIITGAGSGIGLETALQFAAEGARLIISDINLANVEAAAQLMNTHFPECGAVAIKCDVSKEQEVKAMVDKALEVFGRLDVLFNNAGIMHPADDNAINTEEKIWDLTQNINVKGVWFGCKYAILAMKKNKPDPSKGLGIGGSIINVASFVAIMGAATPQLAYTASKGAVLAMTRELAMVHAREGIRFNSLCPGPIRTPLLMDFLNTPEKLNRRMVHVPMGRFGEAVEQAKAVVFLASDDSSFINGTDFMVDGGLHKCYVTPEGEPAQPGPTGLLATFSKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHR8</accession>
    <name>A0ABR3BHR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_106805</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610763.1">
        <property type="nucleotide sequence ID" value="XM_066761223.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993658"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04105">
        <property type="entry name" value="SR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0240255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="320" mass="33962" checksum="B77F8952FCECA4C2" modified="2025-10-08" version="1">MSQPWMADPAITVKSQSEIRPEASSLTALLAHPLLQDPKFVAAAGGLALLLLFLTLFRQDKKTRKRNGPATVLLVGPSDGGKTSLFTKLIHDIYPQTHTSIVPSDTTFDLGSPYEDGQKKQIRLVDIPGHPRLRDEVKKYIADTAGVIFVVDIQGIVRNASGVAEQLPPILTALSNISARLPPSAPPPKLLLLAHKADLLARPTPSSSHCPPEIPSSTLTASTDRLKSILTREMDRLKSTRGGTSGKIEGIGKVAGTSGGFFSNLFGGRAGDAGGEDEGDEDESLIWGGKGPFKLAMYFVNAASTSEMSSGVRAGLEEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHZ6</accession>
    <name>A0ABR3BHZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CAMK/RAD53 protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106588</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610837.1">
        <property type="nucleotide sequence ID" value="XM_066761012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993443"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="9">
        <location>
            <begin position="69"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="202"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="601"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0240338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="77114" checksum="4E6DDF532CE80210" modified="2025-10-08" version="1">MSQTPSQQPPYSDDAFEPTQLSQAAYSQTQNTQAFVSSQVEPRRKYWAIFISTHSDRGILKVPWSKPYIQLGRGPSTLGNDVILPEKRVSNTHCRFTLGMQGAKNLELSNDATRAWKEGEGEPEVWVEDLKSSNGTFVNGARINTRRLLRHGDEISLGHAGTLDYHDVRYIYRSVGGKRLKNGQASSSSGDLEPVGQVYEKYQLLDRLGKGTFAEVHKAVDVETGNMRAIKQIVKHRFAGNDKTLQLFHREINITRSLEHENICRLIDWYEDPQHICLVLEYVDGGDLLDYIMNWPDEQGGLPEQHAAELTVQICRAMAYTHSKGITHRDLKPENILLTKEHEGTRIVKIADFGLAKMIHTNTMLVSMVGTPQYLAPEIVMQTDQQPGYENVVDSWSVGIIVYSMMTKALPFDEDSKLPVEQRIRARFTQPPDISLLEQRNVSRQAIDFVLRLLDKEPARRMTMSQALDHDWLSEPSSQPMESQRIGLGGDSMWSIQSFDSLQPDFDLGYDNGPESIANWQRPATVSGTRLESGVEGSDDFSQPLTKLHLNTPEGGNIPSKTASSKHTATTTTGAVGINTNTPVSPLSPLVAGSHVDIVSPSAPTSASPTFLSKTKSKQKQKRKLGHEKGGKSIDSEDQGLENVIHRTDNVPVNESMDVSGEQAPEPAVVESVKKDGKDGVASGRRPRKSMRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI03</accession>
    <name>A0ABR3BI03_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610832.1">
        <property type="nucleotide sequence ID" value="XM_066761007.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993438"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="492" mass="55323" checksum="D1E85BB8E721EC7C" modified="2025-10-08" version="1">MSRTKEKEKDKHAHSKLIKPLRSCNLNVATDEPKAVKKGIYYIAQVHNKDPKERKKEPVVAQILRALKIKHSAKKGPWSGANVKDNESDLKVNTTKPDKVFRKTETLNNKATKELSFELVEKEEEMQEPEPVFKVGDKLPELQHPVVPAKVTQQPFSEESERQKLTSKKRAKISKSSTQAFQLSKNVIYPLRSSNDTRDITNDSAMPETKRSLPSHPMQKVISPHLERPLQSPFGPRATFSTGTPLARRVRSASNLFCKRSTSKLGIVTRKPVPLYIDVPLSLNDGHISGVSIFRGDVVQTQTPLETTSSLGSHKVSFCPKVQMLILQNNPLLATPPTPKFNISADIFFPEHSLTRRKSLFIVNDSFDSYEQYQNTLFEDVLKTWGLPLDVIHSKEIELSKTGAAAAPAAAVVPSNKGIVNNVPAVQKQRTQRTVGFLNPPIKTNWGLKKFISMDERRLRKPVGRVKDIVEIFEDRSVDRAMTPIRELGKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI09</accession>
    <name>A0ABR3BI09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_106593</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610842.1">
        <property type="nucleotide sequence ID" value="XM_066761017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993448"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="14"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0240343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="138" mass="14743" checksum="0689C42A5B0EE14F" modified="2025-10-08" version="1">MSSKVGGGKGGKSKTSSETKVLTTRSSKAGLQFPVGRIHRFLRNKNANNVRIGAKAAVYVASIMEYLTAEVLELAGNAAKDLRVKRITPRHLQLAIRGDEELDLLIRATIAGGGVLPHIHKSLVAKNAPLKKPKALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIQ9</accession>
    <name>A0ABR3BIQ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cas1p 10 TM acyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_106348</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611051.1">
        <property type="nucleotide sequence ID" value="XM_066760779.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993203"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="9">
        <location>
            <begin position="381"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0240552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="960" mass="107777" checksum="9E38E0631199B33A" modified="2025-10-08" version="1">MPNSSKRRSQATAAKLNPLWYTYACATLLAAVVLGNFLRWAFLELPDSYHCSALLNTGKWLDPGTWTNWQPEGCFQLPLPAQSWQKCLASPTVNTHQSLHSSYFDKRTALFVGDSTVRQLYFAAARKVGKTSKAWESEGEKHTDRSLLVNDPLGGPSLELEFWWDPYLNSSKTVGLLSGHSPVPSSLLVMGSGLWYLRNPSSGGLASWGAMIYDTFELFKKNQGSPQTALINPWDNMLLGPGVTLPGLLPDQPPKSVDYSPEVEARSFLSRASSISRRPTDFSISDAIVFLPISTPVPEKLSPSRAETILHTDVEAMNADLYARLTHPDPPPVIMPSVFNQLLVDDETEDGLHFSDKIMNKQAELLLSWRCNDVMRHEGATGTCCKRYDWVTPVQGLILAILVLWAPLGTLIAPRLRPKSPVHDYLPSPSIAPALSTFGLAMGYLFLADRTHIFQKEQKDYDSIIFGMITLAAFVAGLLTVRNSGKDLGFLNRDITDEWKGWMQIAILIYHFFGASKISGIYNPIRVMVASYLFMTGYGHFFFYYKKADFSFQRVIMVLVRLNLLSVVLPYTMNTDYAFYYFAPLVSWWYLIIYATMAIGSRYNDRPAFLLPKLFICAGLVTLFMHFPWLMADVFKVLNTVFNIQWSAKEWSFRVTLDLFIVWAGMLCAYGFVKFKEHQISDRPWFPVMRTSTLVGSVLGMIWYLWFELHLPSKFVYNEYHAVVCVVPIMSFVFLRNASPALRSSTSKIFCFIGQCSLETFILQFHGWLASDTKAILLAVPSTRWRPVNLVISTICFIWLSYRVSGATGEITEWLIGKKKALPPPATSTGPSTSSSRQATTPMFTTASAMQAVVEGPQDGAKGGVPESIPLMNQADKEVGGLTPVEDETLERRDSWPTWMASTAASFTGRTAEGYAPLTRRWKDQTVLSVIQNLGDLMKKHNSVKIAVILLGLWILNWIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIX0</accession>
    <name>A0ABR3BIX0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="10">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="10"/>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611111.1">
        <property type="nucleotide sequence ID" value="XM_066760839.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993265"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0240612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="434" mass="46880" checksum="FFFC35F0DCEE10E3" modified="2025-10-08" version="1">MSRLAPRLAIAARAVRQPTAARAIAAAFAAPLTNQTRGYRSQPMRDVMTGEIIQLPDIDPSTVKIDLTSNPKTRLPNSKLVFGHTFTDHMLTIPWSSKSGWGTPHIKPYGPLELDPSSTVFHYAFTLFEGMKAYRQEDGTVRLFRPDMNMARMNRSASRIALPNFDGEALTELIKKLIVLESEWIPKEKGYSLYVRPTLIGTQNALGVGPSNDALLFVICSPVGPYYASGFKPVQLLATTKYVRAAPGGTGGYKLGANYAPGVVPQTEAAKEGYSQNLWLLGPEHALTEVGTMNLFVAFKKPDGSVELVTPPLDDVVLPGVTRDSALQLAREHASGKTSLPGLPEKLTVSERKLVMADLVEAEKNGTLVEVFGTGTAAIVSAVDKIGYEGRDIIIPTGSDGMGDIAKGILDRITAIQTGEIEHPWSVVANEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJE2</accession>
    <name>A0ABR3BJE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_106095</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611303.1">
        <property type="nucleotide sequence ID" value="XM_066760542.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992950"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="34"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="204"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0241921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="383" mass="40589" checksum="0DB43FAA8CBC8558" modified="2025-10-08" version="1">MSTEGRVITCKAAIAWEAGKPVSIETVEVAPPKEGEVRIKILYTGLCHTDAYTLSGSDPEGAFPVILGHEGGGIVESVGEGVDNVKVGDHVVPLYTAECRECKFCKSGKTNLCGRVRATQGKGVMPDGTTRFKCKGQDILHFMGCSTFSQYTVVSKFSVVAINPKAPLKTSCLLGCGITTGYGAATKSQGIEGSNVAVFGVGCVGLSVLQGAKAKGCKRIFAIDTNPKKKEWAEKFGATDFVNPKDLPEGKSIVDYLIEETDGGLDFTFDATGNVGVMRNALEACHKGWGVCTIIGVAPAGAEISTRPFQLVTGRVWRGSAFGGVKGRTELPGIVEDYLAGKLWVNEFVTHNETLEGINKGFDDMHAGDCIRCVVDMGFNEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJM7</accession>
    <name>A0ABR3BJM7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611008.1">
        <property type="nucleotide sequence ID" value="XM_066760736.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993158"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12414">
        <property type="entry name" value="RRM2_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="233"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="424"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="761"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="839"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="874"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="944"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="981"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="991" mass="109209" checksum="0948732B9F0B1BD6" modified="2025-10-08" version="1">MAEEDFIPLQGSAGKKERKERVNTTLFVSSLPYTATTTDLLTHFSYIGPVRHGFVATDRESGKSKGVGYVTFSLKEDADRAIQELDGGSFGGGKRKIQVKWADERASLKDRKAEIKVSKPIPGQTDNKSTDPKAIQTLVLTGLPSDITKNVLWKKIRKVNEKAELVFPVEAEEGEEAPKDTAQIIFPTHGDALKALPKLHGHTYKGCILSCVLKKRLEKLSAKGEGKAPSHAGRLIIRNLSWDTTVQDLRKAFLPYGPIHSIDLPTLPSKLPPSSDPTKPPPPPRARGFAFVWFLTRHDAEKAIEGINGKPIKKGPDGEGRVVAVDWALSKEKWQEATKGEEKMEGEKKSSDSGSDSGSDSGSESESDSESGEGSDEESEKESSDDEDASVVSASEESSNADENEEEEEEEPVKPTLPTVDVGSTLFIRNLPFETTELELNTLFRSFGPLRYAKITIDKATGRSRGTGFVCFWKNEHADEVIEEAQRVAMETGANSIPLGGAAPKNPFALPSLLTADPSSSLASRLVLHGRTLDITRAVTRETASQMKEDTERLRNAADKRNTYLMREGVIFPNSPAAEGLPESEIEKRQASFNSRKALLRGNPSLYISKTRLSIRQLPLFVTDRTLKRLAIHAVKTFDKEVADGEREGLARAEEMDGTMSAAIAARGDKSGGKGKGKGGKKERETAVIQSKIVRQTEKLDPITGQGRSKGYGFLEMRSHKDALKVLRWANNNPEVGPLMWEWWKVELGDMKERVEKALTAARKREEEPQKEAAKGSKKGLESVEELESRLKKLDGRLEEDDSRSGGGMRGGKTLMIEFSIENVQVVKRRVEKITTARENGKRKADVIAAEDTDDDEPASSKSAGRFDKRAKRDGRDGRDGRDGREGSKGDFRDRQGGKFGKDRFKGVQNGQKRDHSDRGGRNERGGRNDRGDRPGQVQPRQPGRRDQKSVDQVKKDVKTKDAGEKRGIEKLGSQLGSLIGRKRKMRKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJQ9</accession>
    <name>A0ABR3BJQ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein DGCR14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611408.1">
        <property type="nucleotide sequence ID" value="XM_066760647.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993055"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0242026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="71885" checksum="4003DEF4FBD236D5" modified="2025-10-08" version="1">MPGDRLLGADAHALLPRSPPRIERPPPRGTRSLYQQHILDEDTYTAALSHIIARDFFPHLPRIHATNSYLAALQDNDPQRVSSSIRTLAALHQPDTTGIDDARSAEYSMAGTPYIAMPGLGGRTPVGTRGWDTPGTTRRHRLADFDILDETPACTGQTTRKRQRRLPPVRDDLSLDAFQRNFTSEDNASFVQILDEENRRKREEKFGWAFEAERNAEARRIEGEVKRKMILDTATSGRWRVDANGRRLIGALAEGSDRADGEAWDVKMIQPKPETEEPGAIHPTSPTSSSALVKLSSSSDAPPPLTEIPLPPKHPLAEALADAGLPPTALISSTDGKIVPHHETASGGGSGGALTVFAPHGDRGRGDDERKEREKRERQVLGEEKAETLSAAGSGVDMWKYKARNNLMFLPDANTNPYPDPSSSTSTSTSGGPRPSVKYANTRLHDDDPSWAAGTSGTSGEKSKRSSSSVRGSSPSRSLIDAAVRGTPYRHGEMPSVNDYLLVRPDASPSPHDLPSLLTWGTLLATPRALGGTGEGEGEGGDPLEGADERPAFKLPETKKRDELGRRLADKASRSMRDRARGYSNTASLTPSSTLRGERGKKIGSMGPPATPRRQADSLTPAAKRLLEKTVGRTPMSTSRSASASGSGSSQKNMGWTPTPRYSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJT8</accession>
    <name>A0ABR3BJT8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611035.1">
        <property type="nucleotide sequence ID" value="XM_066760763.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993185"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14691">
        <property type="entry name" value="bZIP_XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="197"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="452" mass="51020" checksum="1365CA6739F0A9CE" modified="2025-10-08" version="1">MSGPVPQNHSFSPSTVSVHFTCFFLSRPFILPSNRLISHFLLSLPSSPLSSYLLLTVSTILSFHTTTYSHITKHLTLHAQNRRDFPSSYCNCCKYKDPFSGAYQTRKRSVMFPQDNFFNSDHSSTPAVDGDVAAPPSTSYTPEFSASRQSVSRSPEDFGTSSHISLGDTNFNHSSVTESSSSSLTRKGKGADNGGGDTMTARRREANRLAAQRFRSRKKGYQDSLEEKIKELEQENRALQGKLEGKNETPQRDPSSSSKHVSYDHYSWAANSHHAPPILPSSSAIRPDYIEVQHNHEFRIRHLEALNQALEEELREVREENKRLRDEFAHWRMATRDWSEEENNRPASSNEPPKKQLPQHRSQSWTRASHPFSSSYHPPPGSHPRHLHGGRLPPVEDDPSYFSAAKHPDQRMPIDHYALQLPPLRTPSSGSVPHPSPPLASVRHRSPPLEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJV4</accession>
    <name>A0ABR3BJV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">beta-glucosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 7"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611464.1">
        <property type="nucleotide sequence ID" value="XM_066760160.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992565"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF10">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="8">
        <location>
            <begin position="381"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0242082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="832" mass="91889" checksum="83D6AEF028408660" modified="2025-10-08" version="1">MTKMAVIDPEAVLKELSSEEKIALLSGDDMWHTVAVPRLGVPRVRCSDGPNGVRGTAWTNGATASCFPSSTGLAASMDVDLARRIGEALGEECRARGVHCLLGPTTNCQRHPCAGRGFESFSEDPHLCGHMALAWIEGVQSKKVMTTPKQYLRRSNNSVIDERTMHEIYLEPFRIQCKARPAVFMTSYNRVNGLHAAEHPFLLRKILRGDFEFQGMIMSDWSGTYSSSEAVQASLDLEMPGPTLMRGPSLERDIISGKLVPADIDECALRVLHYVQEAQQSGIDFEKLEETIDTPDVRALLREAADSAVVLLKNDKDVLPISSPHGKKIAVIGPNAKTASYAGGGSANLAPTYLVTPLEAITTHAHKVGAKVGYTIGSDNSRWTPLLTPFIHHPTMGKDAGPGVQCDFYIQNPWENKVKPIFSKYNNSAFSYFIDGIPKEVPVRGYVSLKTIFTPDESGIADLFIDGKKIIDNSTDQKEGLLFFNTGAEERTGELNVEAGKLYDLEVRFSNFKQLNAMSPYTGRRGGIRIGGRKKRDFQAEIEKAVKLATESDVVILCIGTNSEWESEAYDRDDMKLPPGSDELVRAVLSSKPETIVVNQSGMPVEFPWLDDVSTIVQAFFGGNECGTAIADVVFGVVNPSGKLPITWPRVLEDYPSHEGFGHPIDTIYSEGLGVGYRYFDRRDHPKSAFPFGHGLSYTSFTLSQLSVKPEIFGAKATFTLTNTGEIDGAEVAQVYIHDLAPTVERPEHELAGFMKVYLRPRESKVVSVNLDHKAFSFYNVHEKCWIGRKGDYEIRIGTSSTFIHLSKPVHVAKSFRWIGLQEPEVYEPAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJX5</accession>
    <name>A0ABR3BJX5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_105728</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611482.1">
        <property type="nucleotide sequence ID" value="XM_066760178.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992583"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="13">
        <location>
            <begin position="79"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="14">
        <location>
            <begin position="218"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="669"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="701"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0242100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="712" mass="80334" checksum="BA73F317AD675B23" modified="2025-10-08" version="1">MATNPNTPAPPATRTNPISLRIYKAIGTSFDDVSSREALEIASGMYGPEDPKGKGKVQSEYEELEEDDDTLPKRRTLKGQSAATARKYLKQDIETSLATGSAKFLEAFAEKLNVLREYMQEMQVRCDQVQSELDQANSGTKFLLERADVLRSQRASAQLRAHLITLFLSRFVLSNSELAALTSREVTIGQPLFDTLDHLEKIRTDCEVLLGGEEGKTQAGLDIMSVTSEQLQSGYTKIHRYCQFEFRQFTRETQLEVSPVMRQAIYRLRDRPALLADAIQTLTSTRQSSILQQFLDALTRGGPCGLPRPIEIHAHDPTRYVGDMLAWVHQTTATEHEFLEGMFGVKEKGRWVGQARELEEGEEERMASEVLDKNLEGLSRPLKLRIQQTIKSQEGIIMAYKIANLLQFYLVTMRKTIGEKAILVQTLQDLLRFLHPPDATLTPPITLRDAAHILRELLSVYSTSLIDPAERESDEDLAKLLDKAIGPCVEMCERMAEMRRGKSGGGEWERDIFMVNSLGYLEHTLEMFDFTTRMLHMLDEKIKTHVESMTFEHHGKLLEACGLAAVMRTIRTRPADSPLSRLDATSPKSLTSALSKFSTWLSTVDPSTSPRLALLTSSRLAEEIHRKVLRKIYEAYGEVCERVLDKAEGYEFGETMLRRGREEVGVALGVGEDWESEEDMGQRSTKNKEEQEGSAEDQGDKEEKGIVQEEQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKB4</accession>
    <name>A0ABR3BKB4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-rRNA-processing protein fhl1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611622.1">
        <property type="nucleotide sequence ID" value="XM_066760318.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992724"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="158"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="730"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="730"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="796"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="896"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1050"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1191"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="817"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="905"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1054"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1079"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1191"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1222"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1247"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1269"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0242240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1281" mass="135572" checksum="CCF3A3907035D325" modified="2025-10-08" version="1">MSHHPPAPSLAALPVDTSKTDPTPAYYKLQFGDDLTGFSYYVRTLNVVIGRNCERPAPVPPPAITNPSVPTNPPLDPNEPSPPSLYSGSILRTPPVANFNSPSVVEEDHEVNLEDYGPLVELAEAVAVKEEDVADNISPVLELPDAPPPPPPPKSSANIEHVDVDLGPLKSVSRNHAKIEYRSDLGRFCLEILGRNGAWIDDRYYVKGAVVPLAQGAQIQIATRIFSFVLPPSSVSSPPYNYYDQSTLENVENLPYPYNLPASEVRYQEFFGEAGPGPATAAAMASRQPPAFNAFAAADGYGLGLGMDVEGQWGQWESEEESDSDAERDYEQSFERDSERDAHDEDQAEDEDWDEAQSDEEDEYEEVKPKQATKIKLKKPLIVPGEDESDLSSLDSEPERPLKSVKKQAGKKQSQSQSKFAENEKAKAPKDAKKSSKKESKSKKKVKEPTPPVEEAPGEVKGTPSKSKKKEKEKEKNQADSGAEQKQDTPAVTSDEKEKATPQKKDQKKKIKPASESKPSAKPAPGLKLPIPLAQQQQQQQQPAAQPQPPSVLTLAAALANTPTPPTTAPTPAPQPAARPPQQPFRPSAGQPQQGAVRHPGVPGQPGQPMIRPGQPGVPMGVRPPMSGPGQIPVRPGQPHPHLKQPLPSTPGVRPPVPQTSVPRTTPSSAGTTPQPTQPFFCTELKETAGRPGHIIVNVPIPPSGAGPRPPPGPILGLDGKPFIGPPPLKPTSTFATIIHKALSCLPRGRGTLGEVCNWVAGEWEWFRLNVDSGWQNSIRHNLSLNKAFLKVPRIPEDDPESKGSVWIIDPQEGPLFEEKQRRDAMKSASKDKNAESRREKERIRAEERAKKQREAAIEAARNPHAHPSYVHHPHPTMARAMPPMATARAIARPPANVAHPHPQPSTTQPTPSQPTSANIKGVLQPKAKITVVMQPITPALRTKSVIANTDSNGNPLPFVCDGTTLVLDQSTFGHLTSDILDKLTLLGAAGAVDVLSAWVINKNKMQASKAAQQAKTCATGTTTTSSAAPGVAGAKNGIVNGAVRPTNGVQPARPQPHVAPKPNTIPPVRPVVPPKPAATPTAPVAAATTASANPTPSTTPAVKPASANTPKSLPGPAPPGTSLTKVIGMIAAVANAKGDVNTVGPNASALLRYIRVVGVEIDLRVAERIWATGVVPPLPVKKVAKPANGAATGSAVAGGAKPAQGAGVKPQGQAQGGAKPVQSTSVPASASNATGVAGMKRKLEDGAQGQGQAQGNSNGVASGTGVDQEAKKPRLETSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKK0</accession>
    <name>A0ABR3BKK0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COA8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611692.1">
        <property type="nucleotide sequence ID" value="XM_066760388.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992794"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018796">
        <property type="entry name" value="COA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107">
        <property type="entry name" value="APOPTOGENIC PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10231">
        <property type="entry name" value="COA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0242310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="196" mass="22799" checksum="57E2605D286CDE28" modified="2025-10-08" version="1">MLPTTRPRIAHVVPYIQHFAASTSTSTTPPDPPRKRRSNRNDSPTTGVDLVAPPDPLSNIRPIIYASKPPTRPSANSPYSASEFPSSSGDAKLDNMELEWRLRRERVDLANHRFWAANNIAFNAQLDHRLSLLPPASDPPTPEDIRRKEDCLTQFYADWQMTNQERQIRWVKEWWREIWEGLRIQTRLCVMRAFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKW2</accession>
    <name>A0ABR3BKW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611798.1">
        <property type="nucleotide sequence ID" value="XM_066759852.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992252"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="158"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0243431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="338" mass="37810" checksum="4E65E6AE9DA2458E" modified="2025-10-08" version="1">MSVPCISLHDFDKRRDEIIKELMDASMNVGFFTLCNHGISPEDVQAAFDLSREFFALPDEIKSKTPLNGKNAGWEKNTQVRPSTGTADQKESMQLQFARMEGLWPSDEDVPGFRARAEKLMNQVQALSVNVMECFADGLGLPHDIFTDGTVECGENDCQNVLRLLHYHATEGKHFGPNFWRAGAHADFDILTILFQRDGEGGLEVCPGRKVVGDFGMGQTWIPVEARQDKIVCNIGDQLMRWSDDRLKSTYHRVRLPEGNERQGPRFSIAFFNQSRTNTVIQGPQKKYPPITGGEFIAEAIAKNRMQSAEIARQAALENAEKVATEVHFVPKHLSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL05</accession>
    <name>A0ABR3BL05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105446</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611847.1">
        <property type="nucleotide sequence ID" value="XM_066759901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992301"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15467:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15467">
        <property type="entry name" value="ZINC-FINGERS AND HOMEOBOXES RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="161"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="163"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="418"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0243480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="590" mass="66055" checksum="3C9EE259107EFA95" modified="2025-10-08" version="1">MEGKNEDMHTPRGPEDASNIADEYPSPERQHQDDMLGRDIQHHLDMHERDTRDTDSPGQTDMQMELAKQVAAQAIEAAVAHVQVNADRQETEETEACGQVSSGNERNIHMREEPHMSNSQHHPRQPVFPRPRQPFTALSPPNVATSVAGPSTLRRSPLPDTFSRSSTLLSANDQIAILRESYARNPNPDRKELERLAAKTGRPWNKIREYFRQRRNKLRGLDQLEKMEEPGRASGWLQITYRSAPVTSQVPQLALYNSYRHRFDPYSSSTPLLGGQDLIQLACATFPGCEMARDDGGYVLKGLKEKDKEREETLGNNEALGRKGREVDPEEWERGMEGLVEPLRAGSWLLSSFQSQPGASGSNITQTDLYTSYAARFSSLLTGVSGTSNGNAHLNGQHGLSDEETELRNHAESLKAFEDAGLGDTQGEEDQLSTVEESDQNEPSPASFPIEPNPLPQAPRESRLLTPVELINLTRMTFPACEPCVDASGRFVIKGLERREGLEPGRKSREGQMFPFALMSEKQPGEEFVKVMKRKLASLHPEGAERRSDGESKRKRDEVLTEEDKELIEGLKRFRGSKLGEQVRDVCVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLD2</accession>
    <name>A0ABR3BLD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenine nucleotide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105572</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611972.1">
        <property type="nucleotide sequence ID" value="XM_066760026.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992427"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="158"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="310"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0243605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="48129" checksum="CF0AD3CD0D3CC74B" modified="2025-10-08" version="1">MTPAHHPPLTPFGSALAGALGSVFANSLVYPIDVAKTRLQAIDDPLEDIQSDDESEDAFTEKTEEEQKRHVEGKALRHQQREQLIKLKKMLGKKLQRWGMLTMLLRIVHTEGISGVFHGYGASMIGTFSQQFAYFFFHTFLRKTYLARLTSSSKRVSLSTSTELLLGALAGALAQIFTIPVSVIATRQQLWDPPARPKVLPGGKEAEWNDKSPSLTETAQEIIAESGWTGLWTGLKPGLVLTVNPAITYGVFERLKSWRLSTKGAKKLEVWESFWIGVGSKTLATIVTYPYIFAKVRLQAKVVESPPPLSKEIKKGEAPTYASIASTSPTESSTVLVEQPSSTEGESSTQLDQSHRRKHLHSPSQHYRSAIPLLKAVYIEKGFKGLYQGLSAQILKAVLCQGILFVSKDQFESYAWLLIVLFARLRTRFLTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLF9</accession>
    <name>A0ABR3BLF9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="7">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PAN3</name>
        <name evidence="12" type="ORF">I308_105597</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611997.1">
        <property type="nucleotide sequence ID" value="XM_066760051.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992452"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25586">
        <property type="entry name" value="zf-CCCH_PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="297"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="7">
        <location>
            <begin position="584"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="545"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="375"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="444"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0243630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="684" mass="75530" checksum="33796F5CA39CBBF3" modified="2025-10-08" version="1">MLPPPKSAAVQIVRPPSPSSEKAKEKEKKPSPEKRDTPQRICRNVMIYGYCKYQDQGCIYYHPPAGVDSSTSQNNSPATQAPTLSASTPLIGTPAREKPTLSIEHLAAPVFVPKGLDSSPRVTTPNVPSPSAPTPPVWPSLPSTGLLPRQDVQVSTQPSHAQLSATASPMAYDDPSHIALSAAHTHPQVQALTHGMLDPHAHPPPVDQSMYLPPRQPLDYNLYAAPLPSISGNPLYPTHPHAFFVSDDLRRTIQAKQEAVYVGANGASAPGLPQELGVYHSLVPLPLPSATAQRLPTQSQPSKVYGLPSPVYRATSEVDGNTYCLRRVEGFKLVNQLAFASMDTWRRMRHPNIVGLKEAFTTKTFGDNSLIMVYDYHPLSETLYDEYISPNLPEPSSAFALANRPPKRRSSPSERVLWSYVTQIANALKAVHSSGLAVRNLDASKILLTGKNRIRLNGCGVWDVLAFDNKTPVQAFQQEDLLSFGKLIISLTCDFFQPTLPLSLPLDHISRHYSSDLSNLILYLISKPAQGKVKSIDEVIKMMGPRILNELDAVQSYADVLENELGAEVENGRIVRLMTKLGFINERAEFELDPRWSDTGDRYILKLFRDYVFHSVGVDGKPILDLSHVLVCLNKLDAGLDERVMLVSRDDQSCLVVSYREIKHCIEAAFNELKNAGNNHRVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLG8</accession>
    <name>A0ABR3BLG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612007.1">
        <property type="nucleotide sequence ID" value="XM_066760061.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992463"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="110"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="553"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0243640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="592" mass="65793" checksum="C3F37D56B6D97248" modified="2025-10-08" version="1">MSFDYIRKLVSGNKARFVDPEAAVNLDLVYVTDRIIIMGYPATGVAALYRNKRQDVLKFITSRHGEKWWIWNLCPLYENAYSPESMHNRVSRYPFPDHHPPPLPLLPLAVREMTAWLEGDGERIAIIHCKAGKGRSGTLLCSYLLSLPELPPPPELDRSYSYKELAKRLAQREEQKARSQGPSASPSVEDAEDREGWVFIGGGKEAATLKVDDDPSVERGGTLTPARSERIQVGPVVKGNDHDRDNDNDTASSFSSTTTISRPSPPPSERIELQTTPPYDPIDIGDERPAGQKGQGDRADGRVDEVFKLHSSRRMKPTSTGRGVSIPSQRRWCRYIHLLFTKQAPPSYLSLTPRYLRLLSATLLLSPPSGWQKPIASLLVGSGGTGQGKAWASVARYDDKYVKELQNRGGTGEGVEGEITWGGVAGDGRFDSHKMFRSFGKMVPADADETVVAVLPKDHQKYVVHHLEPNHSHITLDRSREFRLKLHIGNLPLGWAWLIPAFHLPEPSSPNTGEGGEAAKRVHTLSFPRSQVDFPLGPGAALHQVLIRLEEVAEDSVGRDGEVPPRLMNDEEERREGVENDSKEDKVKEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLQ4</accession>
    <name>A0ABR3BLQ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611755.1">
        <property type="nucleotide sequence ID" value="XM_066760451.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992857"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="604"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="515"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="746"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="835"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="761"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="776"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="801"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="862"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="890"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0242373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="961" mass="98780" checksum="3A57A967BB625E6D" modified="2025-10-08" version="1">MAAPPESLRSLPSPTPSSSSQAHSRFGSLHRQTPQTSSAPSTHSHPSPNPLNEHDAHANPAGTTTTFQPATYLPSVSSSPPPNPPPYIPPPQHAMPPDPIHSMTSATGYGQPLMSWANAPPGPNAWRNGGGVAGGPFAGYRGVIPNGRHLPTNPDYPVRFGARPGSAHGESRDRRRERRDKDRDDERELEEEIISTIFVVGFPDDMSEREFQNIFTFAPGFEAATLKFPSGSRREPAAALLAELTQLAAQQNAQGGEYSEYPLGNINLEEAISSLSLTTASTSQSTTPSAPMSLTPSVSSNPMLGPGSNPTVPPSSARRQTIGFARFKTRNDALAAKDHLQGKKIDPLTGSVLKAEMAKKNLHTKKTTSSEEIMGFLLRSGRLGLVPGMGSATGPVSVGGPSGGTGAMGSVRDAWESWPNSSSGPGSDKDARLNIDEKTTVNASSQPNMITIPSSSSASTSTSTSAPAVPTPTSPSLRQTDSKALLALAEEADELEGWSVNGALGMGMTMGPPYEGYSSVSAPGQGQGPAPGQGQGQRRLGSQPGPSGSAYGRHRHGHGAEYGTNATGTILAGEHVDGAPVGGIGLSGGRIIGANPADQNPPINTLYVGNLPAVSPPTHPPGFLEESLRALFSRCPGFKRMSYRQKINGPMCFVEFEEVLYASQAIKELYGHNLGGLVKGGIRLSYSKNSLGQRGNNHPSQINTNAFGGIAHNVALAGMSMTSPTTQQHSLPNGAVGYGLPGSLGEGNTSLGMGDLRRESASGTAATNGASTGTSLSPTAQPFNITLPPTSPRSRYFASPPLSTSNSHKLSPTESAPASASASASASVSASASVSAGSSFNSNTTNGLSTTGMPTPGGAGVGVPIPSSSSRSSTSARSTTSVFHPFGQPSNSISTSVNTNTSSGFSPVSSPIRTPASFSWLSSSAGTGGGVGYGYEFGGSVPLGSLNGAASAWGQSAERRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLW9</accession>
    <name>A0ABR3BLW9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612156.1">
        <property type="nucleotide sequence ID" value="XM_066759509.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991906"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="312" mass="33492" checksum="8D7D0A5B6FF471C9" modified="2025-10-08" version="1">MVTPIDDTNANFGWFGTTWSTNHTVDPLTYEYYDGTLWVSQISIGIYGISVDSGDTQYYSGYSEKSTFQQVLYATNGLEEGDHTLKVSNENARNTDEYPNYIWLDVDYAAITGSLTNAASIGSVVIATTIFSTLTAVSSSLTSSSSTPSTSSLIPSSIPIPSSSLTLTSADSSSIAQETLASSSSLRSSSDFPASTVSLTTTNGEQSSAVQSSTGSTAKSYQSVALTQSFHPQSTGTPSTAVISSQTDSSSAESDNNSATHKTTAVAISVTVIVIAFIVIITITGLWFWRRLRRRRYEEDEDERDHLTPAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM35</accession>
    <name>A0ABR3BM35_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612221.1">
        <property type="nucleotide sequence ID" value="XM_066759574.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991973"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="299"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0243854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="640" mass="72967" checksum="77D3C69AC1EBCF06" modified="2025-10-08" version="1">MPKGNSPRTRIAVIAGSTIAFLFLLHFLFSSPDRLLATQRWTTASSSVIRSKFLRAKAQAPKPPIHHPIPKLMADAKDEFDQKIKKQSKSLPEAVAEYKKRYGRNPPKGFDEWYAFAKENNAIIIDEYDQLDRDLKPFWLFSGEELRRRCIQVGFLPSVDLVRVEKGQTRTIDVSKGFDDSEVGARAKGFRVMLEKFQAKLPDMDFPINEKAEGRILVPWEENLYSNLTADSSLGIEHVLGGEFIPDWRGDGNVWEAYRRTCDPSSQARRLFGSLRANLKEGQAPISRLADAGVTADAPSEDFYFPEGVDDKYDFCSHPWAHYNQGHFFSDWRTIHALYPMFSPAKGMGYSDILIPSHYYFSSTKRYTYGWDPVNMVIKDVDDMETKWEDKSDDIFWRGATTGGGSSPPGFLAQYQRHRLIKMTSDSSDVNKTVVFADPPGTDHFISAQVPIGQLNKDMMDVAFTKAVGCTQYPGGCDGMRKDHRFADAVPLGENWRHKYLIDIDGMGYSARLFALLKSESAVLKSTVYTEFMSEWLQPWLHYIPISQMYQEIYNVHAFFSGPSKSMLDASNSTRTLYQQPGVHTKKFDGDAELRKIGKAGRDWMFTIGRKIDMEIYVYRLCLEWARLTADDREAMSYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM45</accession>
    <name>A0ABR3BM45_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Proteasome assembly chaperone 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in 20S proteasome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the 20S proteasome chaperone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the PSMG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612231.1">
        <property type="nucleotide sequence ID" value="XM_066759584.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991983"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010044">
        <property type="entry name" value="UCP010044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="268" mass="28454" checksum="67A4EC601002FEC9" modified="2025-10-08" version="1">MSDFTSCASFSPSSFASSTLILPAVSLGNVPQLTADLLIFSLGLKRVGFVGKGDTVAPFAGRGEKGGEIVTGGIEVYGQEGSELYVIQQRSPTLKSQKDRHITLLKTFINSHAFGAVLILTSLDSAIQNDAQLLTPYQRIIPPSLSSLPSQLKKIQNIPPLSLSLSQPATSVQNITSSYPPFLPAAGLTRRLLTALSEEKTPIPHGAIAAWCVEGDNRGDSRSFADMVLYVLDLQDVVQVQEPASWEGLFGTTEGWSGGSGADAELYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMC1</accession>
    <name>A0ABR3BMC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine cyclodeaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612306.1">
        <property type="nucleotide sequence ID" value="XM_066759659.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992058"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="38963" checksum="8217CDF4CEE8BF5B" modified="2025-10-08" version="1">MSLRILTGSQVDGILTKLPLHPALESQANVFRAFTRQAKGVTNDQQGAAAPIQTPHRLTVNSDEFSMLFMPSRAPTGTTGQIGQGGKEQTTTACKIVSVPSAGSAEGLPASTIIMDEESGKVKALINARKLTALRNACGSAVFLSRFPPAATKHLLLFGSGAQCLSHALLFLRLHSFSQVTFVVRSINQRSQSSASAIESQFPAANVSLAMHSFPSDELSQLVSTADVIVTATSSLTPLFDSSPTCPKPGARVIMIGSYKPEMHEIDQALMKRATKVVVDSRKACQREAGEIIDAGKQIAGGAGLVELGELLGDTGLPGEAVKDGEDTFEKEVVIFKSVGIGIQDVAISKVVLEQAEINSIGTVIEDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BML8</accession>
    <name>A0ABR3BML8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611208.1">
        <property type="nucleotide sequence ID" value="XM_066760936.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993364"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052512">
        <property type="entry name" value="4CMD/NDH-1_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570:SF2">
        <property type="entry name" value="CARBOXYMUCONOLACTONE DECARBOXYLASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="48"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="131" mass="14474" checksum="DFE28D1C5679B66E" modified="2025-10-08" version="1">MSQPPIIQETEAYKQGMKNRLEVMGKAYVEASLAKNSSPFASLGQQDATEFAWHNVWSRPGLDRKQRSLICLTLLTILGKHAELAGHVRGAINNGLTETEIQEVMHQVMVYAGVPIGLEGFRVADEVLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMV5</accession>
    <name>A0ABR3BMV5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612476.1">
        <property type="nucleotide sequence ID" value="XM_066758989.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991371"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37948:SF1">
        <property type="entry name" value="BLL5189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37948">
        <property type="entry name" value="ZGC:113208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41773" checksum="D43307315F10B2B0" modified="2025-10-08" version="1">MAFIDKDNDKDNDSDRTTPESELHELSDGEYERERLENIKHRDALLSSLGLDVPNNPLETKIAARQPAEKARMSRDDAKRRKVAREREKELRSVDPVRKSRRVAERAGRDKDGNGGDDQNPRSPSYPSSRKSSNPINGHMDQLPKAIAPVLPPGPEYPLHRIESEKQPRPVKGDDGRLVFEGRWRGVFTPNVTPEEMFAGGAFGGSFFRDTYSRLLRTTLSSSAALDSLPFSLPPSDADTDTDVSNLLTSSITQPSVNRFQVLAGQSLEEWEKAGWIWSGDPRGWAEWYVRFWDGRRCEDDERQVKRWLKVAGPTGRFKRALLKKIHQAGGQVAVGDGDVGRVLRQCLWQWAYELTEREYEDATRGLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMW5</accession>
    <name>A0ABR3BMW5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612175.1">
        <property type="nucleotide sequence ID" value="XM_066759528.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991926"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16871">
        <property type="entry name" value="ARID_Swi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="774"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1484"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1509"/>
            <end position="1525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1543" mass="164306" checksum="A5B8A0C1B31ED86F" modified="2025-10-08" version="1">MSNNNQEENPFAGFNMAQLNQLNPALFASLANQMGMNTQAGPSQPQNQAQQPAMGNLRNVPPQLLQQLQQQQQRQQSGQPPSQASINDTLQNIMLPTFNRLQGQNNQQMQQERLQAANNPAIQAQVAAQQVKARQAAQAVQAAQAQAHAQAQAQAQAQAQVQAQTQQQNLGIGVQGMAGIQGMGGLPGMGGVVGFAGLGQNQTQQPNQPNQVQRNQTQFSLHSNQQDFGLNQSTQLQNNNTNVQQENIGQGQNNQFNLGVNMGMMGDDSVRRAALQSMLAQSTQNQNQNQPPLPQPAPSNPAPQISPEVQEFMRTRSDIASAVFKKHGNPQAALEDLQRIVGMLKSQNQSQVQAGNNMGVPGVPVGINGQMFNQRVAPGQIQPAQNQGQSQQVGHQRVPSSGNFELPGSQFANTLSQLEALQQVKERQQRSGLKTPQMAQSSALPMTSPQMGNTANSLNPSFNLTLANQLSNAQNALQNRQTPRMANNIPTLPSGPAAPRPPQGANPIQPGARPPPNQVIATWPLDKLIGASSNLSKKIIESEAAHGNIIQPGKPSAMGLGVPGRTAAEQAAKFQLLVMIAEIKRRAVPVPDDALNVAASLLPVANAKEQILQMEHSQLSEVARATMSQISRQAQAQAQAAQAQVQNQQSQPGQAPGMQGSQGTLNAQQMARFLQQQQQQQQQQSQQQQQNQQQAMRGSQANPIELVTPTMANAQLPHFPTPSQSSVTMAHSASQPPQSNQSSQPLQANPNSTPQLSQATSQSNTGSAGPDVSDIPEESFYGYLRQMMAKNGITSGIPTIEGRQVNLYKLFQMVIKNNGSAHIDPMRWTFVAGQLGFATEPTQPGQPPVSSMQVAQQVRHIYVSLLQPMEDAYMAMKRNKMAQANMRRTGMPPGPGSTPGQVPGQVRPPMNVAGPSITPTLAASQNQSQSQNQPLSEQQRRFLEAAKNAGAGNVGTGVGLGEAWQGQAQQNAGQAGPSQSIQPPTQPQTQQHAGQQTATTTPQRLELSAQKILEFIRMQESLIRNGLEKQPNTDVNPDIYRNELRTILPIAKEAESRLPIYLLMISDGGSVEPQSVLTIINMCTTPSYAALLAERNRFIFNLADFPRLRAGLSQFLSKAQATYRALAEKPVGQAKLKSMVSAVQNAKGLIAQKDREKQAQTAPSAAPASAAAAGSGLGLNLGSTQGVTGIGLDVQQMVQQAHNHAATQLQSGQNQQQQQPPPQPQTLLPPPALPKDSPSNLQEAIRHKGLRVEDLKPPPTKRQKSKGSPATPANAQVPTPESAKTPANTAVVGMQGTPGESPREKKATKRKRQPSSATAAGTDKPAKQTKAEAAKAKKAAVAAAAAVVVPATVPEDPVNALGIQLAAEEAATRAEIAQHKSFFDDQRALASAAAARDDEKKIGGEDAMTLFTKIFEAHQAGIQADMVQTAPASQSTSTTAGHMPPVISTGDPNDQDLFDTYFDATLFSLAADLPTPDLVIEATPQEVDGESPESVKTVGSTAGQAAPGKDVKSCSKEERGKEEGTRIILGSPGSMAYNGGIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMX4</accession>
    <name>A0ABR3BMX4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612500.1">
        <property type="nucleotide sequence ID" value="XM_066759013.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991396"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="162"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="414" mass="46379" checksum="1FFF54EFD81DEA2D" modified="2025-10-08" version="1">MSRPSIILHATPPLHPVPASDAESLYYAALLQLAAPNGWALTRGDWGDNGGKLPFITHLAHPVPPAHLSSLPSFTDPDEVLEDGEKLDSACWKAYIEGTVVDIVNHTYYSLPPNYPSTIAKSQFTGLSFPTNQYIPQRIRSIVKSRLEFVGLWGLGGLNIGDAEDEDRKRQEEQFVVGPGGTTTPRAWTGWRSGQETEKRRRKWGEQQLEQKIRAIFDPLARRLGEKTYFFGQRPTTLDLALFAQLALVLAPTLPNPLLSNILRSSYPSLVAHHDRVLKRLFSSWSSVPMVVNQTPTRTTWVETFASWLPGPSKSRIQPPSSSSTNPKGDGKAQDDPSSKLKTDKQKAFERGRRLWFAGAAVSMVTYLFVSGVVAFEFGDEGEDEEWVTYEEDGEEEEEEEEKTILEYTEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN43</accession>
    <name>A0ABR3BN43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104608</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612561.1">
        <property type="nucleotide sequence ID" value="XM_066759074.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991464"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="100"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0245477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="688" mass="75445" checksum="D449561C45374407" modified="2025-10-08" version="1">MAPRKNKEPASWEVDADKPKPDGETRVRRAYCVKDLVTQPAPGIDTVHDLLLYAAKTHGSKKGFASRDIIKVITEEKEVTKRVGGKEHKEMKKWNYFKLSPYNWMTYEGFLDKVKEIGAGLRVLAADDGRESEKFFNIYSQTSRNWMLVAQACAFNAVPISTAYDSLGPEGLKHALKETEVHSMFTNADLLPTLLKVIDKTETVKIIVYDGEADHKTIEELKNVREGMKVLTLDEVVEIGKKNPVEAIQAKREDVYCCMYTSGSTGTPKGVLLTHGNVVSAVASVWTLLYEYLSSKDSYLAFLPLAHILEFVVENSFIFAGLPVGYGRVKTLTDASVRECKGDIAEFKPSIMVGVPAVWELIRKGILTKVDQSGALKRSIFHFALKAKQAAHHYSIPLLAGLTDTIVFDGVRAQTGGNLKILFSGGGAVSKSTQQFLCTALVVMIQGYGLTETTAMATILNPAFMQFGAVGGPVPAAEVKLIDAPEAGYFSTNDPPQGEILVRGPAIFKGYYKRPDLDKEAFAEGGWFRTGDVGQWNKDGTLSIVDRLKNLVKLAGGEYIAIEYLESIYKSSPLVANGAILANGNHNQPAMVVVAHPHNLPSFAKKNGLGDGEDLEHLCTDDKVVDAALKELNNVGKKAGLKGMELLEAIVLVADEWTPESGFLTAAQKLQRKVIEKHYEDRIKAVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN59</accession>
    <name>A0ABR3BN59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612069.1">
        <property type="nucleotide sequence ID" value="XM_066760123.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992527"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483:SF1">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="56"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0243702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="264" mass="29811" checksum="C19B324917B400F5" modified="2025-10-08" version="1">MSQQDPEAQPLTAEDFEFEQSSFQDTSRPVPSRSPYHLPASEQLQGVANRIIFSRYYILFYGAMMGLSLATLVLSLVATRKGQCPPIAWHIIEFVLNALMVLEVTTRWIANGRKYPMTPLNIIDLTLVFFCTLTLILVFLNPCGSGTRNEELLDTILIVARNTVQFLRLGSILRRSGHSWLNPPKPIDLSQARDASLALDFDLDDEEDTERRFYGDGRGRSLVSGRRGGYEPVNGEEERSGTGVRDNAGREQLSEQDQELWDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNC8</accession>
    <name>A0ABR3BNC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_104700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612652.1">
        <property type="nucleotide sequence ID" value="XM_066759165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991556"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0245568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="123" mass="14038" checksum="4029C924780B07F4" modified="2025-10-08" version="1">MSHGFRQDMPPPGGYETLKYKRNLPVKGPSGAVLFGGMFALCAFGFWRLGQGNVEKRELKREKAWSRINLVPLILAEQDRDAYRRQQAALAREKEIMKDYPGWEAGKSTYNTSRYTPNTIVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNE1</accession>
    <name>A0ABR3BNE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CD2 antigen cytoplasmic tail-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612666.1">
        <property type="nucleotide sequence ID" value="XM_066759179.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991570"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48284" checksum="CBE600A995F0AF1B" modified="2025-10-08" version="1">MSKRAAPSSLPDQKRTRFAPSHTTHSISPSGTPVSLEDDDAYLNDDFESNAAATRQKARRSLRDTGGYASDSSGDEEGVVPSRRPGAKDDDEDDVDMFADDVDEGKGKDKGNPKEKEFMDLEDIEGQEFDKPSQAKDDSDSETEEVKTGLDGDMGIDITPFNMKDELAEGRFTAGGETYVANDEDPNDKYDVWLSDLDKEEIKKARRAHREQQRLEEEREAKEAGGGEEKEKKEQELLHAALGLMERGETVLEALQRLGKQVEDERKKREAGSRKKSWAERQKERKVLMAAQEEQTDSIHTSNPFTNLSNIVSGLTTIGHLDVYSLSRESIQRMLPAPADGAHNPPRAAPPPQPAADNRQFQYRFSMAYVRNLPEDQRPVEREVFGPFSLLQLRGWRSTGFFGPSCENVELRLVPDGGEPGQWGPWTEVVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNI5</accession>
    <name>A0ABR3BNI5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Guanine nucleotide-binding protein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612541.1">
        <property type="nucleotide sequence ID" value="XM_066759054.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991441"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="432" mass="48037" checksum="77C24F7BAB7A08E3" modified="2025-10-08" version="1">MGSCMSTPKAPKNAAETKQIHASTTSPRPPQASTTATATGAGADTSPTSATTSGIKDDTTGTNRTGTSVGQGLAAALASTEPPRPQDSKGNKDRSNQIDRQLEDDQKKIRKECKILLLGSGESGKSTIVKQMKIIHQNGYSKDELLSFRGVIYKNVLDSAQALIMAMRKIGVDPEDVNNRAYADRILEYRMDADLNAVVPSEILYNIDSLWHDPVIPSVMDRSSEFYLMDSATYFFANIRKIAAPDYVPDEADVLRARTKTTGISETRFNMGQLSIHMFDVGGQRSERKKWIHCFEAVTSIIFCVALSEYDQVLLEESGQNRMQESLVLFESVINSRWFLRTSVILFLNKIDLFKQKLPKVPLVQYFPEYTGGADINKAAKYILWRFTQTNRARLSVYPHLTQATDTSNIRLVFAAVKETILQNALRDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNJ9</accession>
    <name>A0ABR3BNJ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612728.1">
        <property type="nucleotide sequence ID" value="XM_066759241.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991634"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="297" mass="32187" checksum="5BBEDEC0F3BF574A" modified="2025-10-08" version="1">MSLSSSPAPTSATIFEPTINHILSLPNLLQPISPSHAALHLARLRLLYSVPVEGQSSSESSSSSSPSPRGIRGIRDKLTLGGWCNHCGGLRKGMGGAQTGGRGQIKDKEKEEKTKAIRERARKRVRELSNLTEDEREEKKMARKLEIAGAVQKRRQPPECTTCGAVYTRPKPDKKTVAEFPPSRKTRRQAAEAKAKEESESLALKAKIEAAVKVERQIQPPQTLLSHPVFSHIPSSPPNLPTHPPPPPAKHSGGPPSATTDVAKKKKKTKKSGLSKLLAENRERNESAKGAGMWGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNL7</accession>
    <name>A0ABR3BNL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ThuA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612746.1">
        <property type="nucleotide sequence ID" value="XM_066759259.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991652"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469:SF2">
        <property type="entry name" value="GALACTOSE-BINDING DOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469">
        <property type="entry name" value="SECRETED GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046695489" description="ThuA-like domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ThuA-like" evidence="4">
        <location>
            <begin position="23"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0245662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="344" mass="36091" checksum="D25507BC9D015457" modified="2025-10-08" version="1">MITSVIAPLLLAAASYAQQSTPRVLVYTATAPDGYRHDSIPTAIEVIGQNADKYGIQCVFSEDMKLFTNETLSGFDGVMFVSNSEQVLDASGEAALQTFFQSGGVYTGVHSASTCLTGDANYGLALGAFFDYHPPYQTATFERLNTTHPSVANVPDRWTFQEEVYYFSSNPRDNGAVVLLTVDEKSYVNNGSNTFDYGPIQGTPHPIAWFIESPLSAQPLMPSAPKAGRSFYTSLGHDNSTWHDETFIGHVMGGLKWALDGASTKAYGVGLVGNTAPPTTSKSTMAPTSSASGGSTAAAKSGSVAAASESSSKSSGSEQVLPRGILMGVAVGILGTVLGMGLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNW7</accession>
    <name>A0ABR3BNW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="3">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_104898</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612846.1">
        <property type="nucleotide sequence ID" value="XM_066759359.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991754"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="16">
        <location>
            <begin position="52"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="15">
        <location>
            <begin position="195"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="14">
        <location>
            <begin position="458"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="17">
        <location>
            <begin position="689"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="14">
        <location>
            <begin position="882"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0245762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1355" mass="145692" checksum="6BE0343B8756934B" modified="2025-10-08" version="1">MLVLPGSSAITPSRRATLLKLFQSAIPSITSVDAVHLHFVNPTSDEAKSLLADTKSAERDILNALLAYGDNEQLDSTKSFIEAGMKGDVFALYVLPRAGTISPWSSKATDIAKLCRLAGHVSRLERGALYLFTSSGSISLREVRHYLHFIHDRMTQLVHTTLPASAAVFPPTPPNPSALISVPILGAEDPHAVLGEANARLGLALSETEIPYLVESFLAAGRNPTDAELFMFAQVNSEHCRHKIFNAKWTIDGHEQKNSLFGMIRNTEKAVHSKGTLSAYEDNAAVMEGYEAPRFAVGGKGDGSYTSQMEKNPILIKVETHNHPTAVSPYPGAATGSGGEIRDEGATGRGSHPKAGLAGYTTSDLLIPDFTQPWESDIGRPAHIASALDIMIEAPLGAASFNNEFGRPALGGYWRTWLMSVKDAEGKEEWRGYHKPIMIAGGLGNVRPQYARKDKISAGSKVIVLGGPGMLIGLGGGAASSMASGASSADLDFASVQRENPEMERRCQQVIDACISRGDGAGNPIESIHDVGAGGLSNALPELVHDSGLGAVFEIRDVLVDDPSMSPMEIWCNESQERYVLAVAAEDLAAFEEIAWRERCPFSVVGTATAEERLVVTDRLLGDNVIDISMSVLFGKPPRMHREAQTIHPERDAFDSSLFTYLPAYAGAPKTSLMAESINRVLRLPSVGSKSFLITIGDRTITGLVTRDQMVGPWQVPVADVAVTRSSYGFDVVVGEAMSMGERTPLALLNAGASARMAIAESLTNLAASSVADISQIKLSANWMSAASHFGEGAKLYEAVQAIGMDLCPKLGVGIPVGKDSMSMSMKWPGEKGEQKQVTAPLSLIVTAFAPVNNVEKTWTPVLRTDKGETVLVFVDLARGKQRLGGSAIAQVFKQLGADAPDVEEAADVRAFFQAVQALKKSETVLAYHDRSDGGLLTTLVEMAFAGRSGIEVTVDAISSSGDAVAALFNEELGAVMQVKTDELSAFTDAFVKAGFPTQHIHVIGKVLGRENQSVSIIHKSEAIYTGTRGQLQQLWAETSYKIQVMRDEPTGAKEEFDSILDDDDEGLVYNVPFKYLPDVTDANRLASPPKVAILREQGVNGHIEMAWSFHAAGFEAVDVHMSDIISSKVSLSSFAGIAACGGFSYGDVLGAGNGWAKSVLLNPTARKEFEQFFQREDTFALGVCNGCQFFAQLKEIIPGTEHWPIFKANRSERFEGRVVNVKVSPEAAKSNIFFRDMAGAIVPIAVAHGEGRPSFVTGSLDGLNENNLIPLRYVDSTGAVATTYPKNPNGGPEGIAAVSTLNGRVLAVMPHPERVVARESFSWFPEEMGKTWEGKGPWFRLFQNAYKFATEGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP02</accession>
    <name>A0ABR3BP02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612854.1">
        <property type="nucleotide sequence ID" value="XM_066759367.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991762"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="216" mass="23380" checksum="AEA7033CD24E2968" modified="2025-10-08" version="1">MPIPSRPIPNPRHRQRPTRPGTAVPRKSLSATPQNNADWRAEMALLPEVGPKSVPMRLSGSMSREAKELSSSVEGKRDVGLERLIVDGKDKRGKRATTATTLGFDFVANPHVIALSESEIPNAPDDPVPRPISLLTTTKSASARPDATSSALSNTPVTPALLATRPDSDGEDEDDHSDDDWEHISALSRPEQVELRDENVCSDGEEDVIVLEGRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP11</accession>
    <name>A0ABR3BP11_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612902.1">
        <property type="nucleotide sequence ID" value="XM_066759415.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991810"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="863" mass="95901" checksum="F1FEB24BE02E509D" modified="2025-10-08" version="1">MSSSSNTSLPSIEQKSKGVRCLGSGGSSKISLGRRVTDVVKAESSSSVGRESRPSVDRSLGSAGSRLERNITDRATTKSSTNQNPPKEYRYQASDHLPVPDAAPIKSYVTESTANRRFPLSSSHAFTQHQPTAGGTIKGVRSGETIIIPQYLPNLSEAPIARAESECLPRSTVAGTIKVPISVQTAPGGSAVPPVRVPTEAAVIQARKIPFPASTIHAHTLNTAPTHHTPSQKPLPPSTNLQMDVLYLAPLLPRPGPLPGPAPTHRHQKPLPRPAVRGVKVVLMGMFESAASPDIGIKTTCMPNFMVETSSEKEATIALQPFIAHHASQRSVNIRPEHVPVPSSTAPPPDICTTHQAPSRTNQTTVPLDTHAARPSHQRQPSARGSHSQPYGSHPPVSTLQYLDVPRSSSSGHGNGSDIGSGKGHSTGSANGRHNLPFLLSPQSNSQFSGTYRSDEDQVSFEVRQGPRRRLRVTLKWLKDGSRRGSSTNGGTSRRERSVQRSDKPPAVPPKELFCQEGSYNSKLPRQKSYRDGLQSEHPIPVNKLPNFDHSSTKNDPSHGHEKEKESQPMYGNWKQNLNSANPAFNPTFNPYYASAPLPRHNPTEVYNVRMPFAYPQPQPPEMWVYRPLDHGQRAEQVQKKGPESLGKESVDPPSERMSPVVANDNISPTGGFVRAAVGVGAYPQSPGQRRQYPWRQGRNIFQPRPGRVPDRWWERLMSTMQTDEQSTRKKLRLPDPAPLDLPRNTQQNRPRNQADTLRHKVPYLRNRIREKEEKRRQRTVKRNERQRLMSEQSKNDQLSRGAFERTDERDWPKDTRNDQLRERSTKKVKDWLTKVRRSGRIQAQLKFGLATEYVPWRSRLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPM0</accession>
    <name>A0ABR3BPM0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0246985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612946.1">
        <property type="nucleotide sequence ID" value="XM_066758498.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990873"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="419"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="697"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="697"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="727"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0246985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="809" mass="90440" checksum="81E00C07E6B56470" modified="2025-10-08" version="1">MAMSMGAAKRGKPRILGPDTSIKDTWAKLAAAIREIQNHNASSLSFEEHYRYAYNLVLFKHGDQLYNGVKTLVVEHLDRLAEEKIVPTFPRSGGTRGAGKLGGGADAVERATEGDRFLKAVKGVWEDHTGSMRKLKDVLKYMDKVHAPTAGVPPVYDLGLSLFLIHIIRRPTIHTHLISTLLSQVQLEREGFTITRSTVRECIDILLRLQVPEREGGASVYQQDFEPEFLRRSGEWYEYEAGEELIKSDASLYLSNVSRRLAEEHDRTIHYLSPSTLPHLQSLLIASLLTPHLTTILNMPGSGLVQMVDKDKYGDLKRLYELFGKVPADQGVEALKKAIRLDIDARGKSINSTTLLPSSSQETKPKPTPPLTLALQWVHSILLLFDKYTLILSSSFASSLALQSTINSSFQNVINAHPRAPEFLSLYIDETLKKGKGKGVGGVTEEEVEEAKEKTIRIFRFLTDKDKFERYYKNHLARRLLGGKSVGGDAEQEMVGRLKKEVGFQFTHRLEGMFTDMRLSDEAANIFGNDPRYNDIPFTLHVSVLTSSNWPPSTLLSLPLTFPPPLLPALERYQTFYDSRHSGRRLTWQGLLGSADLKVRTRKGTWEVNLSTLGMIVLLAFSDLGVGATLSYTDLKAQTSLPDAELGRTLQSLACGKHRLLVKHPKGRDVGKDDTFEFNDSFSSPLARIKILQIAPSPSASSSSTSSAPLGSSSILGGRSSSGVETAQEREETERQIDEERKHQIEACIVRIMKDRKTMRHNDLVSEVAHQLAKRFVAAVPMIKKRIEGLIDREYLERTEDMGSYRYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPM4</accession>
    <name>A0ABR3BPM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor Tu, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613101.1">
        <property type="nucleotide sequence ID" value="XM_066758653.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991031"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="81"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0247140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="411" mass="45022" checksum="919BF9F7C720C404" modified="2025-10-08" version="1">MLRNALQSRLSSTLRTAELRAARPVAGPSVLAARTFVSRPLPSPRFRAAVLTPRCQPTRGYAAESGGKFTRSKPHFKYVRVYVCIAYILASVPSAMSTTGGGKFMDYSQIDKAPEEKARGITISTAHVEYETPNRHYAHIDCPDIKNMITGAAQLDGAIIVVSATDGQMPQTREHLLLARQVGIKKLVVFINKVDQVDDPEMLELVEMEMRELLGQYGFDGEETPIVMGSALAALEGRDPERGAKKIQELMEKADEWLDVPSPFLDGSEVEIVGLGAPIKTTLTGIAGDNMGALLRGIKREQVRRGQVLVQPGSIKSVKKFKAQIYEEGGRYTPFMANYRPQLFIRTTDVTCALTFPEGTEGAHEKLVMPGDNVEMIGDLVHDIALEPGSRFTLREGGKTIGTGIVSEIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQY0</accession>
    <name>A0ABR3BQY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613228.1">
        <property type="nucleotide sequence ID" value="XM_066758780.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991158"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF51">
        <property type="entry name" value="SNF2-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="900"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="814"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1153" mass="129052" checksum="8B908B5FDE7AEB8F" modified="2025-10-08" version="1">MAQYDLIQLGSVTLPAIADSTLPLSSWAPLTSATLDSLASSLPSSRLTIGLISKALSDPGLGFQAEICNKGTSLKIRCRATPSDSQGSIWKRLSWKGRDTVVKGLLKTLERVWEYDDVSEGVLMSLTAEDNQNMQDIYASVPSPEDPLLGETMNPLDQELHDSLSNYENPRGILTSLYLYQIRSVAKMLQMETNPHKLVDPLFTPFREAGNDRIYYINLSTWDIQRHPGWFDLPRGGILCEQMGTGKTLMCLALITSTQHQPTLPPNNNIEICPVFTTIAERSYPFSSYSDLRALTSLPYSQTALAFPSLVELCCNILSIHNPSAKQSCYLPPQIRSLLDRKTFYCMLPPDEDCSRTVRKRRVLNKVKKLYLAKGTLVVVPHILIAQWKMEIEKHIEEGVLKIFEMGSDELPSVEELLDYDILLIDVARFACEETSFREKNNFAPSALLQARWKRMILDEGHVAYSKVSNAMRMAIQLSVERRWIVSGTPTRNLQQGGEMELQEIDLIGIQGSSNNTTVERSPKRAWSKRDVEDATRLGIMMGGYLAAEPFKSEGKFQQYVTTHLRGKNGPSFGAVQRMKYLLSGILVKHGPKVIDIEARLPPLTIVQEVIQFDPLQRVTYNVLAALIASNVYTSGGEDVDYFLHPRNVESFNQVVTNLHLACFWFSARDMEAGNCLARTQQWLRNHPHCSTQVRIKLQEACQHLQTALETPGWGEWMENAISVPCDGSYLPSLIKQAWSDSFDTQPDMVDVHSLSSLRELNVMGADIQGLHMAGWLHRSHKCDWFWEVLTKGVPKHVLEADFGGKAAKAVAKLKNKKRQEGQGKTKTTSAAHAPKAVALPPSKLTKKRTGREDEIDGRLNEARINAVSIGKQVPKPIRQGSRPLPLTIITKCRSAKVNFILQAILDAPKDDRFVIFGNNYELGHLTEALDLLDIASTFVGHTLHVQNRRLALDHFETPGVRVCLMDLKLAARGLNLVSANRVIFLGPVWSLDVQAQAIKRVHRIGQTRPTLVQILVTEGTFEEDIARRSTISRSADEEQLYSRAMIENPRFVYTEKTQTSAFTVRFHPKPQTRNPSESSRETTQASAANLIWQKIDDNPNAKVISASPITLSGAGNVLDQSTLDFPRSVLKKREGDRLEGTVLNKKARVTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQY8</accession>
    <name>A0ABR3BQY8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613562.1">
        <property type="nucleotide sequence ID" value="XM_066758160.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990531"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="3">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="344" mass="37440" checksum="FFFE39610569154D" modified="2025-10-08" version="1">MPGSSSSPHVIQSGATSGLNINLHPLAILNISDVYTRAQCTSTGSEVPKMFGALLGAESNREVSIVNSFELIYHPSAASNEDVEMNDSGSARSKYVLDTDFLEARKEQFKQVFPTLDVIGWYSIGKEPSSDDVSLHAQFASSIETPIFLLFDPSPASDSQALPLKIYESATVTDTTGETSGGEKFVELEYGIETGEAERIAVDGVAKGGTGEEDTAVAHLTTQRNAIKMLYDRIEILLKYITGVVNKSAKPDYSILRQISSLVATLPTMDASEFREELITEYSDVQISSYLTTLTKQLNALSEYAEKHSLVYGQKEDEFMGGPGMGMRGGRQMNFDIGGGRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQZ1</accession>
    <name>A0ABR3BQZ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 8 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613557.1">
        <property type="nucleotide sequence ID" value="XM_066758155.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990526"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="3">
        <location>
            <begin position="934"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="4">
        <location>
            <begin position="1456"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1654" mass="182687" checksum="ABFD340EF99E3CBC" modified="2025-10-08" version="1">MAQPLKTDFTHDSEELDEDLADIPSQIRRSLSSASSGNHTARQSRSSSSATVRNSSTGGLFGRIRGRGKGDVYSDENEEEIEGEELADASSPTPAQGWRSHATDSQDIEAEAGPSDYHERKTATPPTPTSSSLPPSGWRQPSNQLFDPDALEEGPSDYWGAGTPPVVPPYLHQSTPSTTTDSPVINEYDDDEYERRIRDVMTHGARSTPGTNSPNLSVSESFPYHPSQIHGSRLHERVRIDRKADSGIGEEEFGQRKTLTDDVSEATPSVASATPSKLQEQYASGFAPSPSKRTSFIPSSATQQSVQYPQLLQLRAPSHFSQIEMAKSETMSTASAPLQPSNLHVQSPNTPRNKAEPSQGPAFQFHPLRKLSAHLFGRKTNGMSSPRPTINKRTSSVLKVPLGSPTTKEISREQNLGKPTVMDIRGMIAVGTDRGYIVTYGFGQEIKCILGPEEPSKFWMLANKANLPASAITAVTISSDETFIAAGLSSGSIYLYDLSSPSQPARTAHYLTLKQIQSGRREGHLEGSRILHIGFVGTRHTSVVSGDEHGRAFWWSLGKVMGVESTDVIRMLGSYPSGLIPTTAPPYPPKRPTTLFSASPLPLGDSPHPTDKFSLSALLTPSKLVIVGMKPQAKTWFRKMRDGDGGEQGGYIGCTAWLRSGEVSKGLDEEVAKKKVSEEVSDPVIAYSWGKAIRFVRVRVHEVGEDVSPDFVEGRKWEAGESVKSLDWYDSNHLLVITVSELILLDVRSMKAVEATPLQTQLLTSQDFFSGLSVKNIMENVPESFTGSVRTYRGKLFLLTKTNLQVGTLLHWNDRILSQVHRGDFLSAISVALSYYNGAATGNTINLPSEITLRKEMVGKRIKELMKASLEWAFSPDRMSDDTHYSADGRGVDLTDLFEGLAKSCIEACLDIGDTDFLFNDSYEHFTQVGIQGIFLHILEPFIFSGRLREVPPDIIKALISMHSEKGELDQAESMIWHVNPMSLDINQAITVCEAHGLWDAMIHVYTRAMKDYVAPIVKLIGVVRDIQHHRSSRPSLVRDERDGAEEMAPNAYKLYSYIETVLSGLSYPSGEALPEFEAHQAQTEVYTFIFQGRTVAWPQGGHDLVLTVDSNHSEPPYPYLSLLLHFDTEAFLHAMDIAFEDSYLNDPTGAINRQSIVNLMLDVMDPEYFHPGDITLLHIFVARNLPKYPQFLFIPPSTLHRILVSLASNPDQSTREDRQLAAEYLLSAYTPHDGEAMLSLFETAGFFRILSGAYRREGKWGKLISTLLRDPESDDEVFTALEEIIKTATPSTEVSQAVVDALPHLFDLGVRETAILLDKELSSIHPQAIQALGHAPHKQMAYLRCLLEPDPEETHNAPSHNVDLPSRHLYIKLLAQHDPGHVVSFLDERGPSFFDLPQLVNQLDEARLYEAELWALDRQGKVKETFVTVGDVLRTKGGELGESLINDDVGSVHLALETIQGVAKMAVRLCREHSSPNVEDRNESGRGAMEVEDMWLGVLHEIIELVHTSSALTSNSSDTVVLDTLRSLVQETLSSLVSSSSPSLSFPRLFKRLVDASTTTTRQSSKGRAYSEFRTILMGMLDSYRAEGEMLNMTTKLVEADLGEVTAEFAEKSMRGWRAEGGQCEECGRKLENDQNWVVLGSGAALHKSCFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR05</accession>
    <name>A0ABR3BR05_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613577.1">
        <property type="nucleotide sequence ID" value="XM_066758175.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990549"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="294" mass="34099" checksum="4DAF9B582EB5B184" modified="2025-10-08" version="1">MATFNLFFRVIDRFVDGEVAIVQGRKHKYTIPACFKDLYWPRYEVQIHGKYETYRDVEHLLAQARCAMEQEDIRPFFRIYCLFAELNKQNGQNASSAFCGIAADRKHLDYESNLTSSRRLTRSDKKAMMYIKAYAWFMEGIVPIPIGRFKLGASSLVEAIPFMGAIGIFITSFLMYLRTCQSISAPSWLWKEMLVPLIWAVFFAFFMPEIGDIAASSISPSRRAARKVTHWLKLRSLLSRDGQYEDGSWQSRGLAKIFPGANKGGDPYEWRYTDHFRKQLYGEGLLHLYKEREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRI4</accession>
    <name>A0ABR3BRI4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor spt8 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613480.1">
        <property type="nucleotide sequence ID" value="XM_066758078.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990443"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="161"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="522"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="329"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="709" mass="75954" checksum="80EAFB25BAACE4A6" modified="2025-10-08" version="1">MRSEEEDEDEEYYDEHEEEDDERASNADNGEAEGDEDDADEAIEEASDEEGSDEDNADEDAEAEDEEEEEEEEDAEAEEDEEEERDEEEEEEASEDEADGEDATMAAAEDDEAGSIHPSQVSKSAKLPRTDLPPPPHLIRRSLFKPAFMTPPVALSVEAIVGIPLPTPVQSLGSSACLSYLLTGGQDGFVRAYDFWGSVNGSQMMTAQQRSVVGLGEGMNKAGLPRGWWTNEVEGIIGGTVAKRTEPVYSMACEGDALWALTGTQSGPINLFSLRHSPGHLVHTLKGHTNVVSCMTLLPEEKGFVSGSWDGTVREWDLNTGQTVRTYPTHKAQLSSVSLRPVGFPSSPTPSPRPRPSEDEEGNEGPAMNISISMGPNFFDKKGTENSKQEGDNGKEPSGDKEVELLSEQKPSGDAEMADATSAVSGAGDSLFGDDDAEGETAPTSILPTSIPSPSLPSPPKPKPLGLALPGQRQPSPTPISNKETEMAPVSAPLFAPQTSSASSARQGAADIIPVLSPVNWKAYSEDVLLTSSMDGQLVLIDRRVPSYEGTGAGVGRLLPGEKTPPWCMSACWLSNGNQVLAGRRNGTVEIWDVRKGSSSTGPNLLRSLKTPVESGPISCVVAFPDGRHIATASQDNVRLWNAAEVFHSQDSAKRSKGKTPFKIIAGHHGGTISSMIVDRTCRFLITASGDRGWGGESTKAVLIHEVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRP0</accession>
    <name>A0ABR3BRP0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612930.1">
        <property type="nucleotide sequence ID" value="XM_066759443.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991839"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="353" mass="36794" checksum="DE07CF71B7F6529E" modified="2025-10-08" version="1">MFRLTLTKRLALSSTRVIEPSHPRLLSTSYSLFNKGPPTTQGHVLGKGNGDPQAEAAKQGAAAKESSSSGAASASGEAEPFDAARQAGGESKRSKSQETSGVGKGQSGAFKDQVGGQEGSAPGVSYGGQEDAAADRTHQGIKETQPAGHKGNFDDLRKMREEGKNFHTSTRASFPIPSPIPFAPTAANPPGSNKPIESLPSDQNEHLKHSPSSSSDKGKGNAGEEPHLPSHKGQNKGGGSKRQTKGLHSSSRLSGNPSTEKYGKTFPGDRSGGDAPAEALPPHLESDYGPEANQPAPEDLKPSSGLLHSSTAEEPPHPVLSDHAKSGKLAERNSQPTAEMGRQGNSEAWKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRV6</accession>
    <name>A0ABR3BRV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoglycerate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613883.1">
        <property type="nucleotide sequence ID" value="XM_066758481.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990856"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF264">
        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="37"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="120"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="36771" checksum="65300AD7760169E0" modified="2025-10-08" version="1">MSTSHLATPPAEPFTPSREATVYLHTPFHPKAEVYAETKFKKVLRPKDGRTDDLMKQIDGILLRTGDITPEMVLAAPNLRIISRNGTGVDNIPLPTCRARGIAVTNVPGGNAFAVAELAITLMLTVLRRVVEVNNRIRSGERVPSIEVLAPGLGRKKIGLVGMGDIAYELAKLLLAFGCEVLVYSPSSPETRWTVEDIRYPVTIPHIRMSSLRSLLEECDVLSLHCPLNANTRYMIGREELGWMKATAIVINTARGGIIDERALEEALKEGKVGGAGLDVFEKEPAYGERLGGLKDLDNVVLLPHLGGSTDSVTLDGCIKAVDIMASYLDGKGAINRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS03</accession>
    <name>A0ABR3BS03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613910.1">
        <property type="nucleotide sequence ID" value="XM_066757526.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989880"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="86"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="270"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0249723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="536" mass="58130" checksum="8065ADFF046F8559" modified="2025-10-08" version="1">MSPRSPPSPKSLIEAPVPLSSVTHTPKRGDLPSFISTPASPTTITRQPPPDNNAPIQLQMFSSSVDKWLTAKLPPGLLYFISQNVGLVLVAISQLFFVLMGLTVKYFLSATQISATTLILVRMSITAICCVLSLWLIKHDPNPLLGPPGIRCTLLLRGFFGFMGLLSGYQSLKGLTLSDSVTIQFLAPSVTALLGFLFLHETLSQREIVAGFFCLIGVVLVSRPPFIFGREGKGEDIPPPDEVAGGTRLNLPPAPGEVNQQGNDTAERAIAVTWAFVAVFFSSMAYTTIRWIGNKAHALHSITYFSYSCTITCGLWLLFKPGHIVWVSSLRELLFIITIGIFGFAAQTFLTLGLQREKAGRAGLAIYLQVVFSLLLEFVLWGTIPSFLSTLGTVLILASAIWAAISSTPHRAPAKPTDPEAASFSRTPSPIPPPAPGHGCRPHRPSFRDGKRYSYDSFPTSEAEEEREGDIIKKEKGLSRKDSTLFLRKDSALGLDTNFDFPPSRLGPSLGERRGSQLSTSSATSNVGDQGYATFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSG8</accession>
    <name>A0ABR3BSG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614082.1">
        <property type="nucleotide sequence ID" value="XM_066757698.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990054"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="9"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="294" mass="31740" checksum="03F6F4882FC914E9" modified="2025-10-08" version="1">MPKLNLRSTAVKRIMQEAAELAAAHVDDDGFVAAPLEDDIFEWHCTMRGVANSEYDGGLYHFRIVLPPSYPMSAPDIILLTPNGRFELGKKICIDGLTSFHAGSWQPAWGVRTAIVGLRSFWMQSGEALSAIGALDHSKDERRRLAKLSADWECPTCGIRNEEIMPRYPAAVDEKTGGDEGVKQYADSGDTVDQTGACASETGCSGDMGDRGLDSGPLESHPAEPKPQMEATDLRESASPEVISRPAVPTSLPSAQITLEPSRTVPVWLDHLIGGFCIALGLAICKRVGTYILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSL0</accession>
    <name>A0ABR3BSL0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/arginine repetitive matrix protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066757752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990108"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23107:SF39">
        <property type="entry name" value="SS18 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23107">
        <property type="entry name" value="SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="71363" checksum="F4A5D74B72B1FD7A" modified="2025-10-08" version="1">MSQHDLPTRNTHSRDPRLPLDPNEYDPRRPHYQIQQSPPQQPESQQQQQRQQQQERPQNYEFPKSTFQESWRPTPRESYTPKRDAEPKMPKSSEESNGQVNPKPTPQVPIIANVSDTGLPTPSLTAQSSSSVVSSATASGQSPAAREIALDSLAKLRQFKAEVEATRQIRGGAAELEPAKLAKMAESFLLSQQQQLQLQQPHIQTVHTIEEEKDKIAREQELKEQLKARAKVDDSRLVDRNKDRSSSSSSVAARRPRAEDLIDSGKSTSDVEGKPDLRPSSKPPPSAVHLQQDPRFQRRTPAPVPAPPPGNNFEPSANNFVPSRFQNGKGGVPEIGEFKKAHQSSRSPRSRPSMDSIDREKSRENDTTVEGRKLAERISGAYSAGRPRSPSPARSARSSGATYRGRPLSPPPRDSYRPMSPPRRYYDHSPPPRAYPPRPHDVPFDYRNLPDPRDLRSAPDPRFSGGPIDSRDAYRQPPSIGYDRGRDYDRYPPADRDPYGRPHPADYRAPPAPSPLDGSVLETIESLKAQLSQLQEATMHQSYPPRERERDHMPDPYGPPGYAPRGYGREASPPYRSGPPPPRRLSPPPMDRGYPGRDYGYDRMDEPLRRKRWPSIDVDDPRNYRGPGRGRGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSP3</accession>
    <name>A0ABR3BSP3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613320.1">
        <property type="nucleotide sequence ID" value="XM_066758872.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991251"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="138"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="252" mass="27967" checksum="745A4B01977F737C" modified="2025-10-08" version="1">MSGQGQNFSEDERQAAWAAYYAQQGYTPEQITATLGGSSGAGSSSSYTEYSTGPYPSSSYAPTVAATTGPYPAAPSSYQQTLYDSDILQQSSVYTPEGAAEASKYAPKKQGKRETVIRKGNGKVWEDPTLVEWDPKWFRLFVGDVSNDVNEKTLDEAFGKYPSYCKCKVVRDRLSLKAKYAFIAFKDPEDFLKAWKEMDGKYVGNRPIRLSKIKDDKYGSIKTVEISGKKARALEKIRKNHGKPLNGRPVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT98</accession>
    <name>A0ABR3BT98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="5">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="5">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF32</name>
        <name evidence="8" type="ORF">I308_103196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614080.1">
        <property type="nucleotide sequence ID" value="XM_066757696.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990052"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="315"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="759"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="528"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="759"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="845"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="890"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0249893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="948" mass="105897" checksum="6446E0E6F8173260" modified="2025-10-08" version="1">MPPIYVKPENALKRSEELLALGTPQSQQQAFDNLVEVFQSKRFKQTPINVLEPIVAKFIDLCVALNRKAHAKSGLLVFKSAAQTTNIAAIERVLNHFIAEAETRLAAAVEQAKKEVAALPDVPVVDDDLPLQPASLMLDCFVDSAGDRERIERRLIAPAQKFCWDAYDICLDIAKSNDRLEIIYQSIAHRAFNFCKVHQRKADFRRLCEQRLRKDLANAAKYSHQQHAINLSDPETLGRFLDTRFLQLETAVELELWQEAFRSVEDVHGLIAGRKGIKPSMMANYYEKLTEIFKAEGGKQTAVFHAAAWARYFQHAERAGIVNDKASGCVLLSALAVPLGEVEVKQRLVALLNLPKTPTREALVQDAAAKHLKRVPADIRQIYKILEADFEPTTASKVLAPLITSLSPEYQPYLPALRDVVLSRLLQALAQVYDSVTLSHILDLVKPLDNTPWATDMSSLEKFLVTACRRGDIRASVDHVAQTITFVSAPPDANGLQTLAVCLYNTIQYLNPSRLAPVSRSDAFAAAIAQAEEERKAASHKRQIVIRRRELLEEAKLRREKEASTALAERLKIKAEEDARRAKEEAKQAEIDRVRKQIHETKQAEAMQLAASLAAQGALKVDISNIEDLDSSKLVAMQVEQLAKEKKELSERLRIVGKRVDHLERAMRKEERPLLAQDYERQKAEDRAAHDRANQIAREQAIEQQRAAKELKQRLGRMLEDYEAVKERVESQMQEELKAAKEEAKRKIEEEKAQLREKIIRRKREEKERKLEEAREAEERTRREEEEAAQKAEEEARVAAAREAEAAAAEQRRAEREAQRQSDLERIRAQQEREEEALRRRQAEKAASGGAYRPPARAGATPPAASPAPSSGGPSWLARRKAMEAQTGGAPAASSPKPVPSDSAAASAPASNGPESIAGEPEKPALTGSVWRRGMGARRGMPSTRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTE6</accession>
    <name>A0ABR3BTE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103013</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613899.1">
        <property type="nucleotide sequence ID" value="XM_066757515.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989869"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="78"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="346"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0249712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="641" mass="69938" checksum="2FC4555869DAD0D9" modified="2025-10-08" version="1">MSHSTASACGPSNMRPAPPPLAVPSSAQHTSSASNSLSASQASQATSVLTEDEEDLEDYRPGGYHPVNIGDNFNNGRYTIVRKLGWGHFSTVWLARDNVANRHVALKVVKSDGHYTETALDEIQLLQRVVNSAPGHAGRHHVLDLLDSFRHTGPNGSHVCMVFEVLGENLLGLIKRYQHRGVPQHIVKQIAKQVLLGLDYLHRECRIIHTDLKPENVLICIDDVESVVQAELASCPAAVPTKLVGVPPSQGRLGNQTPRKDGIFIVGSQPLPSPSSSYSSSPMLDKYGFGMSKISGASASKAGNQASVAGGPSCPPTQPKKGATTEAIGNGLENVKLGEGSSLKWEKTATPAPAPPKGPSLLSQQLHHPPASPPLNPSVPSGSDSVSTNHTINTSTTDDTEVSTPATTPDHVTRLSDERAPEAGDPTTLPPPFPYDPVSLERITVKIADLGNACWVDHHFTNDIQTRQYRCPEIILGTRWDESVDMWSAACLFFELLTGDYLFDPQPGVKYDKDDDHIAQIMELLGEMPRSLALSGKYSHEIFNRRGELRHINRLRFWPLTSVLKEKYLMEHEDAELLSSFLMPMLTYLPGQRAKASDLLNHPWLEGVVVQGELEMAHSLHRAESERIRREEETKGKGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTJ9</accession>
    <name>A0ABR3BTJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614457.1">
        <property type="nucleotide sequence ID" value="XM_066756988.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989300"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04646">
        <property type="entry name" value="LbH_Dynactin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="179" mass="19454" checksum="29D4AA2522122C75" modified="2025-10-08" version="1">MSSPTLTAHSTSLICADTDLRGPITIGPNVIIHPRATIYAAAGPIVLGERCIVEEGCIIVNRKKDTMRIGENNHFMVGCRIESPSIGDNNTFQPRSTASAGVIVTENCIISAGTILLPSPTHTDERPETLPPYTVVYGAESSRRTWDGSGQVAEMALRSKHAEFLREIIPKFNRLRPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTP9</accession>
    <name>A0ABR3BTP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102502</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614516.1">
        <property type="nucleotide sequence ID" value="XM_066757047.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989359"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="538" mass="58701" checksum="48EC1E3CE9889569" modified="2025-10-08" version="1">MIPPASTPPASNPLLTARSLVLLQLLSRILTFTLNQSLLRLASPSVFGTAAIQFDLVCSSILFLSREGIRNALLRKRDVNNEVEPKGRSQIHALSVAPLQLGMVIAPLITGLYLWSSSQSTTSQQGFHLSLILYVASALIELSIEPCYIQVHRSSPPKIKVRVQAEGGMAIVKAIVTVASLVGLGEGKALISFALGQVAGAIWLAVLYIKEFAWNVKSLVTTQRVEGQPRFDPDTLSLAIANTWQSLIKHLLTEADRLAVTRISPLDDQGGYAVAMNYGSLIARIVFQPIEESLLLYYSNSLSSAATFPLFALTIRLSLYLSTIIQAFVPPLFPAISPLLLPRQYRGTSASSILSLYLKVYIPCLSLNGVAEAFHTASADPSEVKRQGRWMIASSGVFASTLFFLTHLPPHYVSKNGGPFQLVTPNREECLVLASCAAMVIRIVYALRHAKRCFSFRKPSLRWLSLLPSVKIISWACLVRLVLGPLATSGRWERGWKEWAELIGVGGVMGLATLGLIAQAEGGHMKGLRRMMKAEKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTT9</accession>
    <name>A0ABR3BTT9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614562.1">
        <property type="nucleotide sequence ID" value="XM_066757093.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989405"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39636" checksum="5A479DC1A4DB702F" modified="2025-10-08" version="1">MSHLKPVTISYSALAFDGKKEDLQQQVFHALGTHKGALGIVLISDLPPQFLYLREKLFRLAHRLANMPEKERAKLEKPETSYMFGWSHGKEIMNGRPDIQKGSYYANPLMDYPIVSDETRLAYPEYYAGNIWPKGMSGLEDFEQTFKELGKLIFDVGVLLARVCDNFVTPTLANPEGTLSSLIAKSKSSKARLLHYYPEDPNLPIDDNMFNDALCGTHLDHSLLTGLCSAMYLDTSDPPQIVPNPPDTTGLWIYPRESYSPVKVSIPEDCLAFQTGEALSLLTSHRLSATPHFVSGRSSSATLLSRETFAFFLQPDVGDVIGENGETFGQFTKQVLGRHYLDGDIKKKNVAQTAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTW4</accession>
    <name>A0ABR3BTW4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614446.1">
        <property type="nucleotide sequence ID" value="XM_066756977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989289"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="160" mass="16990" checksum="DC3C0E026EE2A6D0" modified="2025-10-08" version="1">MRQLSDLELVAQAMEASDKPSESTSKPNCTSPKEPSNSNEPLSLTNLPEGIDASTLTTEDLASLHPLLSSLSLSPDELEGLDEFQMGGILAQMEAADGVADDLEGKLDRLLETLGGVLGGVEEEIVQEQEQENRVEGEGNELHGGLIEEGEEDASIGDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU23</accession>
    <name>A0ABR3BU23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin structure-remodeling complex protein RSC7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614637.1">
        <property type="nucleotide sequence ID" value="XM_066757168.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989481"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="77892" checksum="EBB96CBAA0F1FC4C" modified="2025-10-08" version="1">MSARTRGKRAAVTSPQASISAIEPTPRTRRVLRGQPDVEEYEELANSNIEDDGGDDDAEGEDAEGEDDEEFMTVSEPPKRSRGRPRGSTNKRKAIVEDGDTDLEQGDGDDEARSRRRGRESVSYKEIPIDERMDGDEDEASTPALTATPRKRGRPPKRPVDDDDDDDKNDSSYKKEKIPGGSGRGGFSVKGAAAAAARARWEKVRREKAERGEDDTPKSARRSTTTKKHAVGPPADYKMGATVSIKNEEYTVGDDELIIPDDPKGDTKIDAAGRLVGDREYKLVTFTSVERRNPERIYALTIDAARACGYSDSLAFLRRYPTVLKLSCTAGERVKLIDLGRISGNLKHRQVTMVAMRNVFKVMGARVIKNGRHVVDDYYEDEAAAKCAENGIEPGSIVQDEEYVPSANLNNERALRSAPGESSRSLAHLSTFYTVGGPTTHFAGNGVDPWTDSGWGNKRSRLRTAGVTEEDWMLRTAEEARAVDEQLRKYREERLKLLEGVDAMRGWVFAAENATEGTTAKSELIGDATDVFRAPVPTEGKKSALSNEVTMEDVGDDGESTSAEEALENKDPDVHQAAVEDKEAIITEEPGKMTSKYNWGLGKSWQPGAVRAVYEPHTNMPHIPLFTQPTIAFLAQTSPYPVLSSATDMQDFHLVQSTITGPAARGLASVEYVLETNEDSQTQQRLTMVEEAEKWERRMRAKKNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU54</accession>
    <name>A0ABR3BU54_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613518.1">
        <property type="nucleotide sequence ID" value="XM_066758116.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990484"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9937" checksum="9818E864996952AA" modified="2025-10-08" version="1">MKRQRNLESVGRQLSPNAEENFANFVQAIRSFAAFHFDSVLIPLNTNQLDLLFYTTNKYYIFSAAAAAAAFFLSCCLQLLLVGARQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU79</accession>
    <name>A0ABR3BU79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">DNA repair protein RAD5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_102678</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614687.1">
        <property type="nucleotide sequence ID" value="XM_066757218.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989534"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="512"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="923"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1021"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="354"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0250500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1201" mass="134377" checksum="8F2281903099C79A" modified="2025-10-08" version="1">MSAEASPETGQLRTKSSPGLFFPATDSEDEEQDDAPLTTAQPTQSTSSKPSFNIASSSRLQGESATKASTAISEASSSANAQNDSDDDFSIVGHNPASSHPQRPSVGPQRKRSLQQAHSNNCRSSSSPAPPASVIPADFRKGFLGEFVCEGWSLSKGRGYCSPGTKIVIERPKNKSGDVDTLKSGRNGSGPVRLVNGKVVGGIKSKQMTLGSMMAKKVEPAKKVKATTDQIIRFRNERGFVGRLSIQEAGFLTHLLDTGVIHLSGNVIDCPQTLTTGCTILLSIKVYLTRKAFENFGRQQREEHFSFWQDQRETAVEEAMRLRKDSLRSLFERIGLKPIQSSALSKVTPIQGVLNGQKGSDLEGPRPRSYSNIATAGEKGKGRAAAPALDDDGEDSGDEAEKLDEEQMNEIDSIYRKAQQGDTRLDEMDPPSTFLYTLRPYQKQALTWMNAREKGDSSVREGSLHPLWEEYLFKKDQLPGEPIEISDDDEPSDSTRKFYWNPYSGELSLNFPTSKNLSRGGILADAMGMGKTCMMASLIHTNREEKLATNFEPQNKDEMEGETDEEPASKRIKFKQVTLSNQWRAVPTAPKVESSTRATLVVCPVSLAAQWHDELRKMSQQGSINSYMWYGGDRVDIEALLAGEGKERVDVIVTSYGTLSSEYQKWLRNKDKPNYEGGSVYDHEFLRIVLDEAHNIRNRLAVVSKACYELKGQRRWALTGTPIVNRLEDLYSLLHFLRVTPWGDYSFFRSFVTVPFLNQDHKALNVVQYILESCLLRREKTMRDKDGRLIVDLPPKTVEIKVLKFSRTERQIYKFLEERAKKRFIELDADGRAMSNYTSILAMLMKLRQCVDHPLLVLGKSGEDGELGEKILESGAGNDEVNLRDMIAMYAGGVRAETPEDVDKAYAAKVLKELGEQEDTPICELCSNEMFDEVLLPCYHRSCQDCIVEWIGRCEDQNKMASCPSCGKGPIRLADLRSVQRRHKRVNPITSAYSAGRDQNSKLSNETPVTLGKVDLVTSTKLRAMLRQLEEMRQQDPKAKALVFSQFTSFLDLIETTLTKQGIRWLRFDGTMSQAQRASTIEEFGRKTNEPLILLISLKAGGVGLNLTMANYVFLMDTWWNEAIEQQAIDRVHRLGQNKPVYVTRYIIKGTVEKRIMKIQRSKTALVNASLSKGAKTKETTLADIKRIFGVDEEDSEEEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUZ7</accession>
    <name>A0ABR3BUZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614939.1">
        <property type="nucleotide sequence ID" value="XM_066757470.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989824"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="10"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="766"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1114" mass="123409" checksum="B9E493FD935389AD" modified="2025-10-08" version="1">MSNTFAVPLQNTRNVTIVAHVDHGKTSFADSLLSSNNIISSRMAGKLRFLDSREDEQERGITMESSAVSLRFDMTRLSPDGTSGIQQCICNVIDTPGHVDFASEVSTASRLCDGALVLVDVWEGVATQTIAVLRQAWMDKLKPLLVINKMDRLITELKLSPSEAYHHISQLIEQVNAVMGSFYASERMEDDLRWREEREKRLTARKEQQGEDLDDEEEYEEKEDEDIYFAPDRGNVLFASAIDGWAFRLGKFARLYAEKLKIKEGNLRRVLWGDWYLDPKTKRVVGRKKLAGRNLKPMFVQFVLENIWRVYDTVLNEHNPDAVQKIVTALNVRITPRDIRSKDTRNLLNLIMQQWLPLSTATFQSIIEVIPPPPSAQAIRLPYMLHTEKAKAAAASGGLKAESELERGLYECDQGEGAEVVAYVSKMFAVRKGDLPEYKPKEITAEEMRARGREERERRAALVAERQAKGEGLDGQPLPEDLARPLESLSLENSQPSASKEPAIDDSDSEVLLGFSRIFSSTLHRGTSLLAILPKFDPSLPASHPHNTKHIVPIIASDLYMMMGRELVSVDSVPAGHVCAIGGLDKAVPRSATLWAPDAKGVEEGSGREVLVNLAGVGIGTNAIVRVALEPENPSDMPKLIRGLQILNQADPCAEYLVQETGEHVIITAGELHLERCLKDLRERFAKCPIQQSAPIVPFRETAVKAPDMVPPKTVGAPRGTVNGTVLNGLVKFRLRAMPLPKGVETFLLSQQGAISKMLVRERGRKEGEEEIDVQEGAEGQSADGEALESQQEARQLSPEEFWTELERLLNKAGGDWTGAADRVWSFGPKRVGANLLLDPVGTKHLRLRGREQLFNQARAQGQSADDALLTTDDAVAADQLASLNSTTSDNEAARADLRLLRDYESSIEAGFQLSTFQGPLCAEPVVGMAWVVESVELDKEGMESEQGKGQVVGGALISAVRDACRQGLLDWSPRIKLAMYTCDIQASTDVLGKVYGVIARRRGRIVSEEMKEGTSFFTIRSMLPVVESFGFADEIRTRTSGAASPQLIFSGYETLDLDPFWVPTTQEELEDLGEKADKANVAKAYVDGVRKRKGMFVERKIVEFAEKQRTLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV33</accession>
    <name>A0ABR3BV33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclease I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614725.1">
        <property type="nucleotide sequence ID" value="XM_066757256.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989572"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF29">
        <property type="entry name" value="S1_P1 NUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045280402" description="Nuclease I" evidence="8">
        <location>
            <begin position="20"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="43727" checksum="5B247730AAA7833F" modified="2025-10-08" version="1">MKLLPLALIVASALPSALSWGAAGHEMVATIAQIHLFPSTKAKLCNILPQEAECHLAPVAAWADIVRNKYRGTAPMHYINAKNDHPQDHCEFGEHGWQNEDVNVITAIQNFTRLIMDGKGGRDVDIPLRFLVHFIGDSHQPLHLAGRDKGGNQAKFLFEGRERNLHSVWDSGIITKNIRELSNYTSPLPSKYIEGCLPGAIFDPYVRWIVWEGIRLWWRDEVNSWISCPVTGDPYPHSSQTSIPPSASTIIKNHFRSAASFALSLLPGRLSALAELSFALPVTETANFEDQALALTPKILAAKEVNMTFPSCPYHWISPIHQLNCDIIWPKNYTGQPNATLIELDTDEYLGEIGRQKILERMMAMAGLRLAKVLNEALAEEGDGVRGVYFGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVD9</accession>
    <name>A0ABR3BVD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101746</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615077.1">
        <property type="nucleotide sequence ID" value="XM_066756300.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988604"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="370"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="478"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="593" mass="64652" checksum="4F4A2238ABA5D553" modified="2025-10-08" version="1">MAKHAGNKGKAPVTDKNNKRKRDAQDNKQEDAPVALFAAVKDTELDDIFAKSNAFSAPAPVASTSKAHLQTTSEPAAKKGKKSPSPEVEEEVEVEEESDSGSAEEEDEEEDGEDNDAELSEIDEELPDEDDDEDISGAESDDEAAKAKEIKKAKKSKLGKYVPAEESVQDKNRRTAFIGNLPIDAAKSKTALKQLRAHIMSFVPSAKIESLRFRSVAFATPTAALPTEDPEKDANQRAKREKERAAAWKAKQNADGEDAELDKAKVFIDAKGKRKVAFIKKDFHSEIDSCNAYVVFAYPHPERAANVAPILDPFEAAAKFISAANSSTFCGRTIRVDSVRLPSSASLPAGASTSLNKRDTWLPSNTDPKKSLFVGGLDYAAKEEDVRVFFEELVKAERGANKEGSGKWVTGVRIVRDKETQLGKGFGYVHFADRESVEEVLAMDAKQIKFAKRTLRVQPCKTIPTANTLQNTIKKVAAGAGGGASSNKKDKTKKPYVRPGVIPKGDPLLGEKLKNLSKEERKNIKSSDADRQARRLAKKKAKMSLEKDKAKGAVKLTLTKSEREKTSASKKPKAKKGKKRAPSAVAKMKGSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVE9</accession>
    <name>A0ABR3BVE9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615090.1">
        <property type="nucleotide sequence ID" value="XM_066756313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988617"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="188"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="451" mass="49119" checksum="9917E77CE6B75D81" modified="2025-10-08" version="1">MSNYPSEPEFQQAVAEIAQTLEPFLAKNPEYRRALDVVQIPERVLQFRVTWERDDGTIAVNRGYRVQFNSALGPYKGGLRLHPTVNLSILKFLGFEQIFKNALTGLMMGGGKGGSDFDPKGKTDSEIRRFCYAFMQELSRHIGTDTDVPAGDIGTGGREIGFMFGAYKKYRNENAGILTGKGADWGGSHIRPEATGYGLVYYVTEMLRDLDNTDWRGKRVLISGAGNVAQYAALKVLELGGTVLSLSDSTGALIATGNEGFTAEEIMKIADIKLQRKSLTAFATGSKFQWHEGKRPWTLVSQADVALPSASQNELNEEEAKALIRAGVRYVAEGSNMGCTLDAIKVFEQSRTAAKNASDAGVCFYAPGKAANCGGVAVSGLEMAQNSQRLKWAHEEVDAKLKAIMINCYQTCWETGKQYAEAGVVPSLVAGANIAGFVKVANAMREQGDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVJ3</accession>
    <name>A0ABR3BVJ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615133.1">
        <property type="nucleotide sequence ID" value="XM_066756356.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988662"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF162">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="445" mass="49492" checksum="DCBE814110B22974" modified="2025-10-08" version="1">MYWYISFLRPPPVSTSNPDQGITITPQVANDLRTELRYEPTTIYYTWQRVIPSLSSLTAPQGLTTFIPPESTYKPLIVPLPKNVQVGESWRLGLFAQNENSQSSNGQINDLKAKGKLETTGELLDLVNDTPNILGVWSEGIEIARPVSGLNTGAVRGIGGQKEPAVDKGKLKGKSKGKDKGKEKEKERDDRPKQGRIMREWALPDKGKLRIAEQTSFDLDKKIWDSGLALSAWFWKYLAGEQSLPLMCQKVFTLLKRQEKLTIVELGTGTGLVSIVLSLALKRIASLERNIIATDLESAIPLMDENIALNNLNSQMNNTSTDHENGQEEKPKCTIIDAKVLDWDQPVPDWVNKDHPELVIAADVTYNTSAFPSLLSTLTSLLHPSSAGLSKKPLLVLAYKERDPAERELWGMLKERGIDMVMGDEIKGAEDYGSTEIWIGRSNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVN0</accession>
    <name>A0ABR3BVN0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615169.1">
        <property type="nucleotide sequence ID" value="XM_066756392.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988699"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="777" mass="79662" checksum="1B894791453AD1E8" modified="2025-10-08" version="1">MTSPPPPPPRPPPRRRSTDASGGLDYYWSSLAGTGPSSSSSSLSPSPSPSPAASAYSDSGSSGSRYSAADYSTPIAGQAEGFSTPVAPPWQERAGRTPPLLPAASSLATPQATVQRALGDTPRSAPAQQPALGGAAPEGRSSATHLAGLLDSSVEPDGQHIVSSPTSISPSSTQHQLPTITHTPHSPVPSPASSSTPARPDRSPSRGATPTLAYSSSVSIAELTELLGGAIDEIGLIDSRDTPPPTVGEPRKHGQKTAMRIELEPKGREPKAKGLEPAAEVVEGPMTPTSLPTRGASLSSTRPTSPTPVLAQGMGEMAAGVASSLPLERTASTRSVTSSNPPFSSPRAGPITLTHSPTILSFQKTARPWPPAMSISTLKSHKPGGDRALAYARAINEIARTQTGLKEWCAAAAAGESHSPSPSPFDFSPHHPRNVSTGSEFPMRADSYTAREISQRVMDPADQPTALPANLPYPQLQLQAQFNPMSSPGRRGGGLKPSQSMQSVSSFTSTKKGSNTSGFLSNIRKGGSKKESLSLGPPAYIAMTSGGVGGGVGKKDVRGLPISAPRSTSPQKPDKTTATMTSTITSTGTSSPQSGSGSGSHTPRTVASPMGPRPLGPRGTSATAGTSAGRGGRGSFTPPPSATAQTTTTERGDRTSISLPPLPGRASLDTSLSRITSSPRAAAGGGGGNARGSMDSVRRIVGGLGGKTSVPPPPVSSERGMMDNNNITNNGEDVKYMADVLPHVEKSVLRGYLKRHGGDQMRALGAYLEDEKNGAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVQ7</accession>
    <name>A0ABR3BVQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615168.1">
        <property type="nucleotide sequence ID" value="XM_066756391.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988698"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="390" mass="42100" checksum="756D1FD397317462" modified="2025-10-08" version="1">MEFVTSPQDYSDIPNQSSTSARTPSPRAFDVVAAYRRALEDDKVPHPIAAILALVELMEASTASTVTGLASELTVARQVLINTQASLGVRAGCQLWERFFALFPGVGEDFPAYKRSLISQGRSFCAITAPQCREKIAELAVDFLRDDCVILTHSYSRTVMQTILRAHKQHKRIRVYVTEARPGCLGMKTHQFLTANGIPCTVVLDSAVAYVMERVDMVLVGSEAVVESGGLVSSVGTYQVALVAKVMQKPFYALAESYKFLRHYPLSQTDLPIPASSDRPSIPLEFPSTIPDTHSIPGFLSRGSSLTPQSRSPQAPATPPHGIDGGGGGGGGGVDGGRKYERMEMTKEMEAINPMVDVTTPDLIDFIITDLGAPLSPTSVSQYLVAQFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVV6</accession>
    <name>A0ABR3BVV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="8">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="8">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MEF1</name>
        <name evidence="10" type="ORF">I308_101818</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615147.1">
        <property type="nucleotide sequence ID" value="XM_066756370.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988676"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04097">
        <property type="entry name" value="mtEFG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="96"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="246"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="811" mass="89455" checksum="DDDD7C09FAEAD648" modified="2025-10-08" version="1">MSAIARAAARVRQQSATPLQRPLLLQRKPILSHALPLHTSPLKPSLATSITSLSSQQTFQRRWASASAKVDEGTKEEVWPERKLPELTETDKLKLRRQRNVGISAHIDSGKTTLTERVLYYTGRIRDIHEVRGRDAVGAKMDSMELEREKGITIQSAATFADWVAPKPPTELQEGETVGNTEKEKFAINIIDTPGHVDFTIEVERALRVLDGAVLVLCAVSGVQSQTITVDRQMRRYNVPRLAFINKMDRAGSNPFRVIGQLRGKLKMNAAAVQVPIGSESDFAGVVDIVRMKAIYNEGVKGNQVIETDEIPESVRALAEEKRAELIEQLSEADETLCDLFLDEAPITPTDIAQALQRATTSLRFTPVFMGSAIKNTGVQPLLDGVCAYLPNPSEVQNQAMDATLPAHAPTVPLVPAVDAPLVGLAFKLEEGRYGQLTYMRVYQGELKRGSMIYNARTGKKVKVPRLVRMHADEMEDVESVVAGEICAMFGVECSSGDTFTDGSSTYTMTSMFVPEPVISLSIRPEGNETPNFSRALNRFQKEDPTFRVHVDSESQETIISGMGELHLDIYVERMKREYNVACVTGKPRVAFRETITEAAKFNYTHKKQSGGSGQFGRVIGSIEPMETDPDTGKDTAFENRIIGGNIPNQFIPAIQKGFQEALDRGLITGHPITGCKFILDDGSAHAVDSNELAFRLAAIGAFREAFNKAKPVVLEPVMTVEIVAPIEFQGNVIGAINQRKGTIVDTEVRDDEFTLTAEVALNDMFGYSSQLRGMTQGKGEFSMEYKNHQPVLPNVQKEMAEAFRKKQLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW08</accession>
    <name>A0ABR3BW08_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BCAS3 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615293.1">
        <property type="nucleotide sequence ID" value="XM_066756516.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988823"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048382">
        <property type="entry name" value="BCAS3_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21034">
        <property type="entry name" value="BCAS3_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCAS3 WD40" evidence="2">
        <location>
            <begin position="448"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="896"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="979" mass="105836" checksum="3AEF91C728FB606B" modified="2025-10-08" version="1">MHRRQAIPISPATTPSSLLSPIVSHFPALSGISPFKALRQSPSYDHHNQPSTSPPHSEYNKVVWQEGDLGDGKGIVPLLLVTSPACALQIFSVPTPVASQDPRFPESFNVPEEAFAMSTITYGSSLYRGSLSGVNNGGSLQCSTHNETVLDMALMDGGRVALVTCNSDKTSIGPLALVVVNLESGGAEAKVDLGVGFTAGVHVSHKIIAITISHPAPAIHFLDPVSFLPLFPPIMDAAPNALTQLPTVALSGRLLAYVTSSPAKVSNPNDMGSLVTSSSLRASHSRKQPCPTGQVESHQGALISSAVEIGGGVARGVWAGLKLGAKAASAATRARSDRLAQSAPDDTATFGRDQETKIHGDAESRSLDDGSILDEVLPTNAANTKPIEKGEWIHVIDLFSRHPSSTCQVSPQGNATSKPTPSFTTIAHFRLPPSSVVPIDTSHSSQYHSLPVQHLSFSPSGTTLLAAPADGRSFHVLEFHPAPLKGNISTGSQSQAWHLYELKRGHTIAKVRWTSWDRMGNWVGIGTDRGTIHIYPIHPSGGQPSALTHAAGFRNAQRLFALSIPVSPIVRIRPPRLVTDPSHLEGNLDPDSTYSENSVFGFLPYRQHQKLDQRHTQNIGIFRWPAGVLEITRMTVRGCREDDSEAGAAKYSSGSPPHRARSALTELMLSRAARERNSIAAEKITLAKWALPSAVAMSSPTLLSRTKAEKSQRSRMGALAAAEIRTHHFNPHVLPSSIYLSRQIEFFSARPIDDYSPLSILDLEARTDKLVFRQEVEARSPPNEDTETPLSFDQPLLSALHDLMESPSDRQIPGLPNGYGRTGIWMGDPIQTVRYGLNEGVDRVRREYVRAQLIKQRKLAKRNKETSGLSLSFEDDAVLAVSNTDLRLDNPPFDQSESAAVSGGSSSIPTSEHSTSPPGSGDLPPTKVDSSDGDSQWGEVWEEEYRKAVEDDGGPDDLVLGLLDEEEDERRKWEARRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW48</accession>
    <name>A0ABR3BW48_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614268.1">
        <property type="nucleotide sequence ID" value="XM_066757884.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990242"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="2">
        <location>
            <begin position="658"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="805" mass="88540" checksum="5C7E631823118826" modified="2025-10-08" version="1">MFSHISSALYESLFHASAIDLVIPDVSTFNPNPSDEDLPTWWNALEQESARNTAYFDEDLVYFVAMTLPDESVVDLSGSPVVDAKEPTSEILRFLGRLDLTMSASFVPKLPAMEVRGTPATSTTNGNLSAPPTSATLAPPTLGHFQPGPPRANPSPTNPPITPNPFPAMSSEEEQYANAEGVVVWEGKVEESKAGNQGEDKNEDWHPWGRRVFRRNGSWEVIWKGEIPIVYVRTNVENPVLSLTASVTLRDQNSLSKAHRKGFSLDAISIHSGGTEYEDYESDNSEDWAGMEEIDLLGGLAGKNNMMPATRLPATLRKDLFIPDGLLPSATPLSAVTPNSASPFAISSTASTGVHHERGHLPTTTVPTLGATLRKSFRRILAIAPGIRVKMNTVTLPQLLPFTSSSISNDEDHQGETRVAIVIHLENSIESSILHGFEISRIDITIGGKSSGITTKLLYQTEGPSGLGIFPIRLGSTEQYNLFYVVDFVGERTNDPLQESIARNLGASEQIRPVSIHVIGRPYRLKSLDSDEYDYPTKMFDSCWNTSIDLTNFYTSRPPSARLSLQNPLLTGDPLHPPSLSLSNPVLGDKRYNMASLVLAEQEREKGSAQTRNRPMMPSQVMQNRRIVSNVRVPSMNGPPRDYGLLMSVKILPQFPSSSPSDTIRPLVPFSIEVFVHNRTDQVRRFRLIVPGREDGIRWEVRVREVLEKGMKKGENLMGVGDEAFLRTSLASYLSASTPFIPLEDNIRCGPLLPGASLSARIRFLPLREGIHQIERLRVVGVGDEVDFMMSPVMDVVVGNGIDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW67</accession>
    <name>A0ABR3BW67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615353.1">
        <property type="nucleotide sequence ID" value="XM_066756576.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988883"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="274"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1152" mass="124358" checksum="500D59757B9E30F1" modified="2025-10-08" version="1">MSNRLSPSPSSLSKPNTSRSPPIKNAKHNRSKSSLPQPKILPFPDLSELRSSRDNSRANTPLSTPAGDRLDITFDQLIMARGNSSDSGTHGRHRSSGSGGRTTPVSAGTSTFLRPTSPPISSPLAITSTRARAFTAPTRPALSPASRSMLVSSPATTRSHDVQDSRLASSSPPRPSTSAPSAPSVAIAPPITPILVTPSSSGPTSSNQAVDFVQRPTTPVKTSHHHNHGYGRSHTLNHSTSSLLSAPTTSVTPMPSFQPISKHLYKAFLSGTCADVRLVVRKWGVYYNVHKMILSQSSFFSSLFLGGFSEATATPKSSYKGKGKARVDVPAEDWHGESIDLQFDDPNITRAAFEICLSRLYCPFPNFHFPASLFPTSSHPLTPSFPFITSPPPYPSLQSSLPPNTQLATPRLLLSLLATSVYIGHGHLLREVLAMILRTVGPLTVNQYLSFAVGEGIGDEEWEGQTAEGASGLQDVAKRLPGASGLRSSVMPPMEEEDEETVETGQKSSGSRLSSDSSTKIGQRDPFIQLNGVPYEPSPTGSSASAQSQHNEFSFASADGADLPHFYGTVGNKIGEACVCWLARWGMDLLRAELETPNPCYRIWAYGGLPARFVRALLSSDLFFVKDEMERYETTRDVLELRRTGWQQELDGRGDLSLADPEVTEQHGWEEWEEDEKEIKLVFAEGIRYCHMTFHDLSSIASNIDPQTALPYAPMSVLQAAHWSAADLRARVTAHERDGNVVGESEDDKNELGLTQTTSSIVEGLRRRRRPAPRSRVASPVAPWGSSHISLAATINSISSVTDISCSSLPSRSHSVWYPVPSDETHRIGASGLLSTGSLSTANISGVPDFGPDLVDVLPQEGNKLKPPHGEKNFFGLVSGKATEKEIEEKWINEGGAFAMSHLGLMGSGNGKEDKWTKIEPFRFSVEFWDVDKLGEKERYYSATHFYAGSLFNCYVQMIKRKEKGVQLGIYLHRQSPNESFPTPSAPQMAGGNPLTRTVTSLSTAPAPSTPAIHGQPLGPSTVIPGSPPSATTRFFTSGANQERGNSLATDAPYHDTRSVTKAFFSISCASALGTALIRFTSGPDSFAHSQSWGWKSSALKSEEYLSSIPAVELSESLDEGVMGWTGEVDTEGIGKGNGRSTLRATVVVGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW80</accession>
    <name>A0ABR3BW80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615358.1">
        <property type="nucleotide sequence ID" value="XM_066756581.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988888"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="732" mass="81315" checksum="7B5440A9D9F40427" modified="2025-10-08" version="1">MPRHAPLSLSSRPGSTAYQQERLRTSVPNNLATADDEVPLRLDPEFAQRTTVLQILNTRQPPSCDNCRTRKLGCSGRPASIEITTEGVATSPCGHCREWDLECSYTYQRKRRGRKNKAVEQLAVQQKARKLSQVTRPSATTQFVDQAGDARDTECSGVGYPVDQGLSAQYNPVSVVGPSSNIDTYPPRQTNLPSPVQARAGHLIPWYSHASAPSQSAILGDIGLNGSTLTSDDRGTNSRIQQPIIHLSVDRHENIAEAHSIVTPSNVDASPYHGVSPSTTLSNVSLPVPTNIESVLPRHLALHVISLYFEHVYCIIPVIHRPSFEKDLSTHEELRRPMFFALIMSIIAATLIHLPKSYFPIPAHKVRPLSDRCVKACCAVTRNEMENYNVDLICIKYFLFVVHNKHGSIGLEASAFGEAQYLAITMGLHREDTYYDLDPINAERGRRVWYLIYNADKFEAVSRQKPVLLRMDEFMGPESTAFPAEVDDECITSEGILPSRTPAPLISGFNTLARIVTILGDILISERDLRRQQTTDPENLLSALRGVRRLGQRIRYITDTLPRPFQLEVDQGSSLPEPGWEDAVRGELDMFFSDPPETKDGYLVLKGNIHVTLAMTRLRLILLRENLLNCSGQPGTSSRNAAELVAADIGENTVNWRHSVYQDLYNVVHCVPIRALAANGPSLVTKIRVVAVTLLDALETQDEMIDPNIQGIATYLLSFLDIMSSIESQFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWE7</accession>
    <name>A0ABR3BWE7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_102094</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615422.1">
        <property type="nucleotide sequence ID" value="XM_066756645.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988952"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="78"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="296"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0252702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="57173" checksum="6011213032D89978" modified="2025-10-08" version="1">MFRSSLPQRTNRDSASEARPSTATPISADTDAVTIEKITNTTQEATLPSNGSSEGESLISRMMADNDSPYFSAGAGLMGIGVALTALRRSITLGATMAQRRMLVTLEIPSKDRSYPWFLEWMAHQSAAQTRGNAKPPGLFGWGQGMRSHELAVETSYKQHENGASEAIFNLVPGPGTHYFKYGGAWFQVKRERDSKLMDLHSGTPWETLTLTTLSTSRDLFSSLLEEARTLAEASTEGKTVVYTAWGVEWRPFGKPRRRREMGSVVLGKGIAEEIESDLKGFLGRGKWYAERGIPYRRGYLLHGPPGSGKTSFIQALAGSLNYNICLMNLSERGLTDDKLNHLLGLVPERSFVLLEDIDSAFNRRVQTSEDGYKSSVTFSGLLNALDGVASSEERIIFMTTNHYDRLDPALIRPGRVDIQQLLDDAAGEQAKRLFVKFYGNSVNEDGTKGRVLREGELPLDDEEVESLGNAVQRIVEDERAHGKVISMASLQGHFIRTGARESLDGIRELCKPREGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWK2</accession>
    <name>A0ABR3BWK2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribophorin II C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615483.1">
        <property type="nucleotide sequence ID" value="XM_066756706.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989013"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046381908" description="Ribophorin II C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="192"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="297" mass="32247" checksum="E883E4F60191305A" modified="2025-10-08" version="1">MLSFLRSTPVLGLLTLLAATSVTAKGALGIKAAKVAITSLDGLNDATYTLKEPTPLPSPIVLSETSSFKLAFSVIDTTSGESVYPQQAYLLLEGLQYDDDDVTLPITVKSNGKAQITINPAKPHPALLPTRGKFRLTLLLSSLNEYTPLAYPLGEICIPESILQPRPRKRHDLPPRAGEPAFQPEQELFHTFKEDPKTVGWAKSGAGIVVTLAPWGVLLALFGKLSPSLNFQTPPVSSYVFLLVLAAIETLIFVYWVGLKLYQLLPPFLALCAIAAYTGLIALRELRERRLKAEGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXS6</accession>
    <name>A0ABR3BXS6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615350.1">
        <property type="nucleotide sequence ID" value="XM_066756573.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988880"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="295" mass="31388" checksum="B534E9E04E7722FB" modified="2025-10-08" version="1">MSTCKSHGYLTVLTSQTIVDSDVLQVPPPVRVINANLEHRSANGNENGLTDVKAQFSGIDEPSEAADYTPAPEGQGEDEGEVLEEDDEGVQEIDDEGEVDDAEDKPLVLEHSNSHIRAGNDGDSEPRQKSTGSPGAQSTPQSVQPLPDTTHASLKQVEDVHEASEAPSESVHEHNASQQEESFAGPSATTDEPTHDAPIPPHHQIPANAVEVANIPPNESEVGKGWLGVEEKTGLEVRQAEDGDAAMGPPVAEEKMDVDSPIAKEDEGLVHGEMEPPVPELAVEGVDEPIEVEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYL3</accession>
    <name>A0ABR3BYL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615714.1">
        <property type="nucleotide sequence ID" value="XM_066755428.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987723"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02118">
        <property type="entry name" value="EthD family reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="111" mass="12961" checksum="AF42A00489257BFF" modified="2025-10-08" version="1">MPTSVTSVVKESTTPTKQFWTWIVLTRRKEDVSREEFARHYHEIHPKLARRVPGLISYRQNLLCPTPGPESSIDSGFDACSEYTYVSKEAYAKAKETEEWKELDRDSKEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYL4</accession>
    <name>A0ABR3BYL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_100867</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615716.1">
        <property type="nucleotide sequence ID" value="XM_066755430.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987725"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF51">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="63"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0253495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="543" mass="58640" checksum="6F99ED0F0B6A8E6F" modified="2025-10-08" version="1">MPSDVIDIPVTEEVTKAHGSDIEKVLEESGVIVQELDSDSSPVIGPAAGKWAAIKADRRAFAWSLYVLFMMTSYGFDGLLTGSVIGIPAFQKHFGYYDEASGSYIISALWQSLWTAITAVAMLIGSLACGQIGDRFGLRITLITAIIFTIAGVLFEQLSRTPGHFLGAKTIAGFGYGLQTSVAIMTLSSFAPASLRGPMGAGLNTFILFGGWLASGTVTGTGTVYPDSTKAYQIPFALQYVFIGIITAGVLFVPETASFYLKQDKEEEAKRALIKLHGPSRMDIVEQDLERAKISRELDDRFKHDGSTVGLLEPFRKPHLQRTLICCAALGFGQLVGASFVTTYLTYFFQVAGAPDNTSLALGQMCFTLMVFGNLVSWYAIDKLGRRVCLVGGLAIMTTLLIIIGITWAVRSSASLWIMVALMSLWAFFFQGSIGACGYSIVSETPSARMRPATVALASATNQVTSWIMGFATPYMVNPDEANMGGYVGFVFAGLCAIACIWAFLCVPETAGRTSAEIDKMWADGVPVRRWKEYTARVGQDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYN5</accession>
    <name>A0ABR3BYN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101998</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615326.1">
        <property type="nucleotide sequence ID" value="XM_066756549.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988856"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="4">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="254" mass="28741" checksum="170E88D7CD641E23" modified="2025-10-08" version="1">MPWLMKAEPDSRIVKGKDVKFSVDDFERIGVSPWDGVRNHEAKKIMRERMKLGDKVLFYHSNCKMPGVFAVAEIAKEGYPDFTAWDPDHPYFDPKSKRDSPTWFMVDVRFSRRLHYPPTLALIKHLATLSNPPKEVSYIGDHGLEAIKNMPLVNRGRLSVQPVDDAAYNAIVELGTKGGWDSLVGISRNAPKSRQTKASDSSSEIGKPKDNETLEGKPHERDKLLPGEDGTFESGQGQRRSKRLKRSLPREETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYR5</accession>
    <name>A0ABR3BYR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional adapter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_101805</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615134.1">
        <property type="nucleotide sequence ID" value="XM_066756357.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988663"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041983">
        <property type="entry name" value="ADA2-like_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016827">
        <property type="entry name" value="Ada2/TADA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25299">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025024">
        <property type="entry name" value="Transcriptional_adaptor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="11">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="13">
        <location>
            <begin position="84"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="14">
        <location>
            <begin position="89"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="12">
        <location>
            <begin position="467"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="247"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0252414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="619" mass="70408" checksum="60EE3CC0F36A4104" modified="2025-10-08" version="1">MTVTQRKPRVDSAQNDSRPIIEPGIKYTCDFCHVDITHTVRIKCAMKQCEEVDLCPSCFCEGKEGLQHKAWHDYMVVEQNSQPIFTPDWGADEELLLISGLIQNGLGNWAEVAQHVGTRTKEECEKHYLQVYLGVGEHGEDLKVKEREADEEMDESQRRRREFMPPMDRSFPYDPDEFQQRKKARIEELRKPQALPPSNAAPPVSAPTNHEIGGFMPARLEFEHEVDNDAEMAVKDMEFGLVMQYGGDEQPQAKITRPPDEEEEDDEEEGREDEKGVVKREKVKREKEKEDEKEDKPVPPAIEDPDELEVKLAMMDIYFSKLDKREDAKEIIFDRGLTEYRAIQAQDKKLTKEERELVQRYKPFAKLQTAEDFEVLVEGLIYEQTLRKRIAELQEYRRMGITTAAEADVYDNVKNTRAMEFPTQKPAEVLPSGARINAGQHRFLHGNMATPLSDSKTREPTPRAVPAVGRKPPQPLNLANSASLDLLSSEEQSLCSTLRVLPKPYLTIKELYIRENERRQGLLRRRDARKMLNIDVNKSGRIFDFMVQSGMLVLAYEPQGKGKASLQAAAAAVAHGAANGMTTMDGQSQGKDMLMERVNGLGMTNGLNKPITHEIRLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ97</accession>
    <name>A0ABR3BZ97_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615930.1">
        <property type="nucleotide sequence ID" value="XM_066755644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987943"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="802"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="9">
        <location>
            <begin position="532"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="709"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="881"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0253709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="917" mass="99758" checksum="A6A50A31E75494F8" modified="2025-10-08" version="1">MSAFLNKLRRPSTSADSRTRRSTSSSTVADDAAPPTSQQAAASSPQRTAGASGSVFIENFDQSPQPSQLGSSPQPSYAETSSPHPKHHSSPMPEPRRTPTRPSPLQVPDSGPRTAGTPKLMLTQEGSNSPRSVSDHSPIYDYHHRSPSQSRNHVGLGLGKPNLQEDGEVDSPANNLNNSPPSVSQRAISLAQDGRDRSGSLASYHHDLASNGHHGFRSRSGSLVSRVTSRIGPVSPNSLTPVDSISKSSKKSKRRSRRRSINSQMSGQSSVVAALAKGGLHIASATGDEAMMKAAKVRKVSSGMKRSPYLTRGGRDMDDDEDEDSDDDDLDFDDEEDDESDLGEDFSVLGYAVASNRRNSDFHALFPTVDEGDYLIDDYGCALSKDILVQGRLYVSENYLCFHANIFGWTTDVVVPFNEIRTIEKKMTALVIPNAIGVYTANARYTFASFIARDTVYDVMMNIWRLCNPNAVMSALSLSATPSRPGSISGEPGSAMITATSGEQDEIGRGGQGGASGDHKPTQCACGRDGKHYPETALEATFPSTPEKVYNLMFNSSWLRTFLSDNQNLRDIEYSDWRPSSPSSPTLTRSLSYTKPLNGSIGPKQTTCHITDSREHFDPDEYIVMVTTTRTPDVPSGGVFSVKTRTCFMWAGPESTKVVVTTGVEWTGKSWIKGIIEKSAIDGQKQYHDDMKLSMLSYIQSHISEFLPPGAKPAIEQPSPPSPSRTTSAAGSGITSAGTTSNEAQESAAAKARKERQDADWWNLQAGIDSLVRGGQTIGEGLKACIDSVADMLFDNGLSKQGILWILIVLLVLSNIYTYLYADTSRSARGIQRGGEIRFSVERGQQQQQQPSRSVYDEQVAEAVRMVLSQQRTMMDPVKEAKDLLRILDSVEGRMSQLRDEIRGVIEDSSAVRQNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZB6</accession>
    <name>A0ABR3BZB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_101048</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615893.1">
        <property type="nucleotide sequence ID" value="XM_066755607.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987906"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="346"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="556"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="14"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="709"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="715"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0253672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="738" mass="82023" checksum="6A9E97386A0E5C41" modified="2025-10-08" version="1">MAGPLSVEDILAKQKAEKEAAAKPKFLSKAERQKIALEKRQSEVREHQEREEAERRQREEFDRAAEEERRRHEQEKYGYNAGPSGRNDRDGYVRDGYGRDNRRNFGDRRNGPGPVIPSGPRGAALPAGPRSMQNGNGGGLPYGSSVQSSPNPLPSTPATGSASPAPASSVASGDAVPPSQAELEALRARYLGKRTDGKKPRLRKAQDKKIIFDWNEQDDTSAADQSSWTREVRELVPGGTMFGGRLAGIDGARKNDVRTDNHADPLERRRAVKGKDDDRHWSDKPLGEMKERDWRIFREDFSIVARGGGIPYPLRNWRESAIPSQILDIIEEIGYKEPSPIQRQAIPIGMQNRDLIGIAKTGSGKTAAFVIPMLDYIGHLPPLNDDNRHLGPYALILAPTRELAQQIEAETRKFAIPLGYKCVSIVGGRSVEEQQFALRDGAEIIIATPGRLKDMVDKSILVMSQCRYVVMDEADRMVDLGFEVDLNFILDSMPATFVKPDDAVALQATTEGDWQGWRVTTLFSATMPPAVERLARKYLIKPATVVIGNAGEAVDTVEQRVEFVHGDEKKKARLIEILRTIGLPPPMIVFVNQKKTADMVVKYVQQAGMSGVTLHSGKSQEQREAALQALRDGEISVLVATDLAGRGIDVPDVSLVINWQMSDTIEKYVHRIGRTGRAGKTGVAITFLTNDDDEVMYDLRIEVEKSKMSKMNPELARHEAARTRVTREMKRKRGDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZP3</accession>
    <name>A0ABR3BZP3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616077.1">
        <property type="nucleotide sequence ID" value="XM_066755791.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988092"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="400" mass="42681" checksum="D35561A75E63D9CF" modified="2025-10-08" version="1">MLSSPRRIPDLDDNSRLDPMTPPPSLVTTYARSTLLSLATPDLPPPNHLRLQNFTAILRSSISDDEWGVSEDLSTLLDGKPVSDFMPVHRDSKGRSEIAKSSSAGRPVSIRRNSGSSTSSSTSEVLFHFTSVTPSKINPPEVLVEFSNPFTSQNSLGVGIPIKLGRRKSSASSIFQGFPSSVNSSSSSLHIAPNGNLNVIGGARDFMTLGKELGRMRLGRRDSLDSVGSSVSSQSSTSFPGVGLNPFAPPFPPSLATANGYFKPPAKPFTMAHSSSSPISQAPQIPQQVQIQTASLPLPRPSSLPPRPGPLPPVFIKRESAALPQPMALPDVAPLGKEWEGENALSGNEKRRRTRTRSRNGSNVSSDGEWGGSPVGKGPERLARLGEQLRESMSHGRAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZP6</accession>
    <name>A0ABR3BZP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101237</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616080.1">
        <property type="nucleotide sequence ID" value="XM_066755794.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988095"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="199"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="286"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="406"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="709"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="673"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0253859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="760" mass="83704" checksum="201311CBDC6EBB83" modified="2025-10-08" version="1">MPSISTRAFPNEVAIFSNYLLFTTLTLKEVQAHAKTPYGHPGNKRPCSLFTLDDDMRYTSFAMDHGPLNLAFTFHACIRIHEKLEKATERGKPVCLYTTTEPKMKSNMILIAALYSLIVDKQPPWSAFRPIAQFEIMPFRDAGSGPMDYGLTVQDILYGVEKAIGNGLLDLASFDADEYQYYEMVENGDLNILGPFIPFASPTESSWIEGALQSASNEHIVHTPVKSKAISHQLHCVLDIFQRENVGLVARLNDELYDRRHFLDVGIEHIEMFFDDGTNPPDDIVREFIRLAEHTIENKRQKVAVHCKAGLGRTGVLIGAYLVYKYQFTAQEAIGFMRIVRPGMVVGPQQQYMVLNQLKWAGWAARDQALKEIAQASCMESNPPIAPPVEVVIKGIETETHIRPVTRFPSKLRPRRSHSSSSLATVSPRRGGDAVGQPRKTRQLVESTTEGEQEKFMRGQSDLLSCSPPVICEVASEVSIDQKENEFYRSTVSSLGSTRGTKRSASRPSSGHEHSNPLSRVSLNVPPSSLSRSNSNVSIGSEGSVDERPPKRRIESSPEVKESGATVSPVSEPMTAKQIETPVRLTVTKKLRRRISSSSPPPAPTFTPSASGTTPLSVDIAASTETPSTPTRAPRAIHNDMSVTASVQRTMPAKKSFLPVRKNVESKSSPVRSTTISTTSQSPSLSTRTSVRVVNTLNKHQSIVVNSNSNAKNVKTSTPASRKLERGGTKRGMLTPPRITEMWGQLSRIGSSPPGDKEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C028</accession>
    <name>A0ABR3C028_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM-dependent methyltransferase Erg6/SMT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616209.1">
        <property type="nucleotide sequence ID" value="XM_066755923.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988225"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="4">
        <location>
            <begin position="44"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0253988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="343" mass="38541" checksum="33DB13F43103C8E0" modified="2025-10-08" version="1">MPAETRSADRVSNYNKFWEKKSANDNDTHRANRLDQYTEVVNGYYDGATELYEYGWSESFHFCRFYKGEAFLQALARHEHYLASMMQLKPGMRVLDVGCGVGGPAREISRFSDANIVGVNNNDFQIGRATAKTKKAGLSDKVSFVKGDFMKLSEQFGENSFDAIYAIEATCHAPNFEGIYGEIFKCLKPGGVFGVYEWCMTDAWDPSNPEHKEIAHGIEIGDGIPEMRNLTAARNALKTVGFEIEHEEDLADRDDAVPWYYPLEGDIWKAQTAWDMFTCWRTSKMGYTVTQNAVWFLEKFGLVPKGTYSVGQSLIVAAKALVAGGKTQLFTPMALWVARKPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0P5</accession>
    <name>A0ABR3C0P5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616424.1">
        <property type="nucleotide sequence ID" value="XM_066756138.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988441"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="6">
        <location>
            <begin position="47"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0254203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="192" mass="20207" checksum="D857480CA40F1DC4" modified="2025-10-08" version="1">MMRNTILRSTAAAMASTSFARPAIRARPVLAAVRTMGASANVSKRGYHAKVIDHYENPRNVGNLPKGDSDVGTGLVGAPACGDVMKLQIRVGEDGVINEVKFKTFGCGSAIASSSYMTERVKGMTLDQAGAVKNTEIAKELCLPPVKLHCSLLAEDAIKSAIKDYQSKRAQRLAAANATLASSSSQPQQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0S9</accession>
    <name>A0ABR3C0S9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_101613</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the YME2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616453.1">
        <property type="nucleotide sequence ID" value="XM_066756167.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988471"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="261"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial escape protein 2 C-terminal" evidence="13">
        <location>
            <begin position="444"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="777"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0254232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1035" mass="113184" checksum="70365DF1D550E18A" modified="2025-10-08" version="1">MIRPRSLPLRYPNRTIPLFRFRNHLISRSILTDSSSALSSSSSSVPRSTASFYISNVFPIQLGRWDFRPSIASLLREEALLEHLHTIASDVKVYGFQVENWEVSRKDGGVFLHFSYIAPAGKGTLKEEEKIDEEKAARIGVELTPSYAQNQPGRLFISALEKSAQKHGGWPSWLGNWWAQKKWHDDRKVPGHTLYSSRAEDGEGVAADVDEGGLVKGSAGAVKGLKGAAGGGGVWVVKGKQWTEDMNRFPSNRLRVEFDGPDVSQEMLYTLFRPYGRLADIQPPTPVPAGSLRFASVSFSRLSPAAIAINALHGYSTPTNTADFTIRALSSATDKPIPLSRLRLFYERPLKAHALRDWISSHPRLVLPVIAFLIGTLSYTFFDPIRAFFVRSKLEGVWDINEYSLIKKLRQKFVLPTSFGFLDSSTSETENSEDAIGKNAWADRVEAEKGVEEWLAEYPSTFITITGPPGSGKSSLVTRVLKQQDKPAMVIDCEEIAKAKNDAGLVSALADQTGYYPVFSFMSSLSGLIDLAAVGLIGQKAGFSTPVDQQLRQMLEIVGGALKDVSTHAQKSHQEALQAQKDQIETDKLRQRKKQMIARGWHDGRLDYVAGNGLSELGYGDEPFMEQDWDSVPAAVPMGENVAPIEGDTTPTSLTASTNKVESEKLELQTMAATELDVESETIKSLPIVVLKNFAQKTAKGDLWNVLAEWGASLVENKVAHVIVVTEGPTATKALTKALPAKPLNTVGLADADEVNALAYVRDKLRPHTGAAINTTASNSTSIADDGTVSQTSGSDPKSFTLSPEDSAQIAKLGGRMVDLENLVYKVRTGSKIKDAVDDIIQRNVVELRKAAFGDDSEDAKALPWTRAQAWKVVSDLANKGEIPYNKMLQEFPFKGAEQSLKALEEHELVSVSYIDGRASMVKPGKPVFRYVFQALASDPVFKSSCQIEYNNAIIAKSESDIKAYEQELMNLKNITTEGGSDALGVSGGWLGLGGNSAIRDRGKWLLDKMGGLVDKVGKLEKENAEMVKVLSSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0W7</accession>
    <name>A0ABR3C0W7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">SET domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616280.1">
        <property type="nucleotide sequence ID" value="XM_066755994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988296"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="93"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0254059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="449" mass="50475" checksum="FFB154ABF0636ABB" modified="2025-10-08" version="1">MADLTAEAAISPSDDILLPALASLRESHPDKGILKLLAQLKVDHPEWAVSEKRFRKALQLAPSPGGGEADPNEKALVADTGLDPSIDVKSIAPKVEVKMFAGGKGKGLVAKEGLKQGEMLWQEEPWIVNSDPGHYSLLTQSMMCSQCFSLFARPSPPLSVPCPHCTTAHFCNRLCYTKSLSSSHPPLLCPGLNPDASSLMDFIRKRGERSVEGVAKILARWRGEREWGVKGKAEEMEKRIWKGMARVSQKRKEMERREWSYISKARMEEWHLIHIMLTNVLNPSPTHENYKSFQRLLISQHPRRSKPVPLTENEVKRWFSFESFLELLGLVGLNQEDSGGLYALHAHLNHSCEPNIQVRNLPKSYTPPTQEALPVDLPPPIQAGDKVSNKLTILARHGIQPGEELTVSYVNMKMPRDERRQALREGYGFWCACDRCVREKEQPNGETNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C148</accession>
    <name>A0ABR3C148_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616111.1">
        <property type="nucleotide sequence ID" value="XM_066755825.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988126"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0253890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37391" checksum="8FB29A872E753893" modified="2025-10-08" version="1">MGLLHLLAFAGGIAAFLFVTLSLEEHSKYAKTIGMRAIYVIIGLHIILYFTDNLPITHVAFSIVCHLVYLSNFSPSWPFISLTSPRFILSCILVVGDHFVWFFHFAAVAREAKHYRVPKYRYGGQQVKAAGNNPSFGDVAAFFAICVWFVPLYLFLSLSANDNALPSFDSSAPPSPSGSHVNLSSPNLQPVADRKHSTSLIKSALVPLLSLLPSIRSRSKRRNSEGLIAPRSPSKSSPLPSPALQSPNYYPWGTEEKPMSSPGFNPPHGSMTPMGRLKTPPPPRRTQSELQIPTRGNLHSGSQAEEGVRKVSVSRQEGLSSSTNLLPAIGNERELFKRKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3Y8</accession>
    <name>A0ABR3C3Y8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616620.1">
        <property type="nucleotide sequence ID" value="XM_066754719.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987000"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42386" checksum="B2F44D719ACE8084" modified="2025-10-08" version="1">MSATALIETTIQHGAEEQFLDLSSFVFPKMYNEQEMFDPFPGFDSSASAPHLVVAVSETPNSGSSIELFAGQHPSRPGTPIRQYTCLELTIEGNDDSEEDTFREDEKEVSYGDDMDWKMDNDMNVTDVNLQNQPHNPPLYIPTPTTSHLYTSTYFSEVPELLISRPDEQHSTRYPRLAQTQNNLPSKRRKANKKESSTWVRRSTRVRSLNAGELQHPHCSVLDSPPNSSSTAASSTESDCTVSPSPEPPRSRHFTSKASNPSRHCLANSSSKAQLVQPERQEERAARKRGKCRRASEKRNLQNKNAQKKYRDKKKNLAIRTFDFAVEMTRLGCTIEGRMAKAFRDTLNEYLEEIGAMDDTYLKEFMDRAGMDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C454</accession>
    <name>A0ABR3C454_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616690.1">
        <property type="nucleotide sequence ID" value="XM_066754789.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987075"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="542"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="629" mass="68885" checksum="DEF7E0146DFBF341" modified="2025-10-08" version="1">MSGIPVFVAILIGLACSFVQSLGLTIQRKSHIQEDLLPLSARRPAIRRPLWLIGFIIYMTSNVFATFFQLDALPIVILAPLGAVSLVFNALFAHMLLGDKFGMSWVIGTALVAGGAVMIAVFGVVPDEEHGLDELLLLLKRGPFVAFFTIVLTAVAAVLAVAHIASWHAHRHQSNQITLSGASTPVSVPSNYASPRSTVAIPFRPRNARHRSSSNSDDHEDEYTKPTVEDNDNPRLASKNPSAQKSRSLSVPHYIHEVSPKPIAESSHTRTLTLCGLAFAAAAGTLSGLCLVLAKATVELFMKTIDHWRTGAGRNEFARPQTWVLMLGMNIIAVAQVWYLHHSLKFTGPALVCPLAFCFFNLSSIFDGLIFYNQFRQLATYQILLVSFGTAILLLGVWIVSAIQPEGNVEVGTWVEEDMISDRTSISSHESRDELEAGEGATLLGRGFTVEPQDDDSHWPLPHHDIGTAFLRDQPVFAPSPSSPHSPMSPRFFHSRSHSSSHAHHHRHKGPRYGSLLHDIGSHGAPMGFSIGLGAASPGFVLRSGSMSEHHHHGEGERNRRRRSEGPLGLGAIIHGDDNSALQTDVEEGHGENATEAALRDWDTSERRTNNWWDVRRLFASQGNIRLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C533</accession>
    <name>A0ABR3C533_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b mRNA-processing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617000.1">
        <property type="nucleotide sequence ID" value="XM_066755099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987388"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10604" checksum="5DAD31FAAE9B867E" modified="2025-10-08" version="1">MAAVRWIKFTVYSSLIIGTGVWLQSKTVPSEKELYSQLSPELKNKMDQIVRHREGSQTMKERLEEAGEKDQVVWGDQLNTKRKPLFPDRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5C1</accession>
    <name>A0ABR3C5C1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617100.1">
        <property type="nucleotide sequence ID" value="XM_066755199.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987490"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="278"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="419" mass="46214" checksum="D8BA80196B6B89F2" modified="2025-10-08" version="1">MASSLQETVPHQPVALPVSPGNIQKEKKARKRAKKVQPPPEGSLSTESKPDAESERPPRKPRARKSKGGENQLIPVPKSNAPAPETKVENEAEAKDKKKRRKRESRAGTEAETKGHLTEDARVDAPAINDKENDDGKVQEEGKGKENGGDKVEKREKTSDEASKEGKKRKRKTEQTHVEPQTTTAEVSASPVAATTAEGNDEPKEKKPKREKRPKIKSVKGAIDISKQPEVDVQVAPEGSESTTIFTDSSLSDQAKKNIFYAHLFALSQSPSPAPNAPSWKFSKAKQNWLMRNIFNHIEVPETYFEVVLGYLKTTQGHSRNTLVEQAKKILEPPEVPAVESVDSAVEKSTDVAVPLETASPKEEPKVENTTQTQSDNVDPDVPMAEASEPTSEQLEKEKEKQIKETRARQLLEAMEVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5F4</accession>
    <name>A0ABR3C5F4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616971.1">
        <property type="nucleotide sequence ID" value="XM_066755070.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987359"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="102" mass="11652" checksum="8726CE376750AD20" modified="2025-10-08" version="1">MSTAFHPQTDVPHPPNCKLVDFCFDRCVGWLDKVGKVVDRRAPRVVGGVFKPLILSTGGLMSFSIADEWKAWREAMPEWVFLRIQRRISVELVEARARTLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5N0</accession>
    <name>A0ABR3C5N0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone deacetylase complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617206.1">
        <property type="nucleotide sequence ID" value="XM_066755305.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987598"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34255" checksum="836D14291F7089F0" modified="2025-10-08" version="1">MPRSPSPSRGRSRSLSARSRSRSPYSNRSPSPSPKGPRTPHLIRVFVTKGRHTPLADFDAGVFPTRDEFQVYAWQTSTPSGLIKLLYSSFPAPYRSPQTRFHFRHVYVDANPRGLYRFKDLTSFIGRDLQSSNNDDSTDLDEDRELSKRGRKIEEKPLDDYGFVTGDFLSVSITVPEPRHPVGSLAAGALAGIAGNSSAGPAGLRDREGPRGGFGWGDRGGDRERPQRSIAPTSAPGEGPDATRWGRGAPLPPQGRIGSRGGRGGYERAPLPEGRWNRDDDRNGPTRPARDRSRSPRRDRRESWGKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5N5</accession>
    <name>A0ABR3C5N5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_100744</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617210.1">
        <property type="nucleotide sequence ID" value="XM_066755309.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987602"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="196"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="538"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="538"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="221"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="251"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="297"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>substrate</name>
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        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="341"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
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        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
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        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="426"/>
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        <ligand>
            <name>substrate</name>
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        </ligand>
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    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="432"/>
            <end position="435"/>
        </location>
        <ligand>
            <name>substrate</name>
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        </ligand>
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    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="607"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="664"/>
            <end position="668"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
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        <location>
            <begin position="709"/>
            <end position="711"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
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        <location>
            <position position="769"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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            <position position="795"/>
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        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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        <location>
            <position position="887"/>
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        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
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            <dbReference type="ARBA" id="ARBA00001946"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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            <dbReference type="ARBA" id="ARBA00004679"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="ARBA" id="ARBA00022533"/>
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            <dbReference type="ARBA" id="ARBA00022842"/>
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            <dbReference type="ARBA" id="ARBA00023152"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0255933.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="914" mass="98932" checksum="1FC997AFB1AE874B" modified="2025-10-08" version="1">MSDSSAVPPLPKDPEGITEQLQSVSTPPPPPRAHKPPRQKKIAVLTSGGDSAGMNSAVRAVVRQSIARGCQAYIIREGWEGLVRGNTSGPTPAPTAPQSPTLSPSSKSVTFSSLPPSQQLDKLTSTLNKESLTNEVSFSDPNEVTPLEDTPLSFGYGQLLRDGAGEGDVDELASHGMQNLAIADHEDEKGRTLKNKYIVRVGWDDVRGWQSEGGTLIGSSRCPAFRTREGRLQAANNLIHFGIDCLAVCGGDGSLTGADKLRGEWPSLVEELYTDNRISDEQREAYQHLNIVGLVGSIDNDMALTDLTIGALTALHRICESIDSISSTASSHSRAFVIEVMGRHCGWLALLAGIATGADFIFIPEDPPKCEDWETEMCDLLQAHRKVGKRKSIVIVAEGALDRNLKPIKPDYVKKILVERLGLDTRVTTLGHTQRGGKPCAFDRILPTLQGVEAVQTLLSATPETPSYMIGIQENKITKVPLLEAVARTQMVAEAIENRDFAKAMSFRDSEFREMLQAFQISSSLDVCQSAPKENRLRIGIIHVGAPAGGMNAATRQAVRFCHSRGHAPVAIYNGFEGLLDDNVSELSWLRVDSWTTRGGSELGTNRSLPSIDIGSVAAGFQRHSLDGLLIIGGFEAFHSVVLLSQNRSNYPAFQIPMIHLPATLSNNVPLTDFSLGSDTSLNALVEACDAIKQSASASRNRVFVVETQGGQSGYIATMGALAVGAVLVYTPEMGISLKLLQEDVEFLIKRYSLDEKGKSEGRLVIKAEKSSSVYTTETLTKIFKEEGKDLFDARSASLGHTLQGGVPSPLDRTRAARLSLRCMQFLEEHACPNSQATHHKPKPAHLTHAGAKSLVKDTAAMIAIIGSKVVYATMEDVLKVTDMKLRRGTDEWWSDCKELAETMGGRTGLMAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5R3</accession>
    <name>A0ABR3C5R3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP citrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_100778</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617244.1">
        <property type="nucleotide sequence ID" value="XM_066755343.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987636"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="14">
        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="13">
        <location>
            <begin position="287"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="CoA-binding" evidence="12">
        <location>
            <begin position="538"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="11">
        <location>
            <begin position="703"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0255967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1150" mass="124711" checksum="7296DCB17535E0D4" modified="2025-10-08" version="1">MSTKAIREYDAKQLVSYWLNRSPTPIPCKTDTSFTAVQVAQVQWDPATKQLSPPIKPGQGLPDWVFTSKLVGKPDQLIKRRGKAGLLCLNKGWEETGAWIEQRAGKPVTVEKTTGTLNTFIIEPFCPHPAETEYYVCINSAREGDWILFTHEGGVDVGDVDAKALKLLIAVGEEFPTRETIISTLLANVAPAKQDVLCDFLIRLYGVYVDLHFAYLEINPLVCLDAVDGKPAEIQYLDMAAKLDQTADFLCGPMWAVARDVSSTTTGGAGIKADRGPPMVWPAPFGRDLTKEEAYIQKLDASTGASLKLTVLNAEGRVWTMVAGGGASVVYSDAIAAAGFAHELANYGEYSGAPTEGQTYEYAKTIIDLMTRGTPHPEGKVLIIGGGAANFSDVAATFKGIIRALKEYKEGLVRHNVKIWVRRAGPNYQEGLKAMRLCGESLGVFMKVYGPESPITAIVPMALGIERPPTAITRDVTPLPSAPVTPPNGAASGSIANIPSNVGAVKADGSREQPNDQIVRFDTEPITGTRPWFRPFDEHTRSFVFGLQPRAIQGMLDFDFSCGRKVPSVAAMIYPFGGHHIQKFYWGTKETLLPVYTSVGEAIKKHPDVDVVVNFASSRSVYASTLEILSFPQIKAIGIIAEGVPERHARELLHLALKKKVIIIGPATVGGIKPGCFRIGNTGGMMDNLIACKLYRPGSVGYVSKSGGMSNELNNILSYTTNGVYEGVAIGGDRYPGTSFIDHLLRYEADPECKMLLLLGEVGGTEEYRVIEAVKKGIIKKPIVAWAIGTCAKMFTSEVQFGHAGSMANSDMETADAKNRAMRAAGFIVPDTFEDLPDTLKVVYNQLVSKGAIVPKAEIEPPQIPMDYQWAAKLGLIRKPAAFISTISDERGQELMYAGMRISDVFKEEIGIGGVISLLWFKRRLPAYACKFIEMVLQLTADHGPAVSGAMNTIITARAGKDLISSLVAGLLTIGDRFGGALDGAAAEFSGGLTSGQTPREFVDSMRKANRLIPGIGHKIKSKTNPDLRVVLVVDFVRKHFPNHKTLDFALAVEDVTTQKSGSLILNVDGAIAASFCDLVSGCGAFTEEEAQEYLKNGTLNGLFVLGRSIGFIGHYLDQKLLKQPLYRHPHDDIFYPSVERVVIQPGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5V7</accession>
    <name>A0ABR3C5V7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617285.1">
        <property type="nucleotide sequence ID" value="XM_066755384.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987678"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0256008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="421" mass="44259" checksum="3C42DB6DC813973D" modified="2025-10-08" version="1">MLPTDSPTSSPTPAHASTPISPPTPLVLPPLLNNFTFKRWGVPRKPKRARADDDAVSTLALPTTTLSTEWGQFSSTDSLVDDPMDGSRPAREKETEKDAPLMLAVGSKAPNIIPAPRPMVRARSSKAKFGRRVDRSSMSGSTAHVNTSSLSSPELSLARTISPVMSHSHSHSYSPSASASAPVYVSGNSSGSSISPSIPAQGSVSLPTSTTVPVSPDTYVAEPTPKRVRQRSCSTSSQSSLTGVLVDQDIVIGNCSISEKGMEGWVPAGGGGPSTPRSTARSGQGNNYIPSPLATAPITSTFTSSSSSLPLPVPSLSHPHPYQLTLPPDQIEIDLIPTAAQLQATKSRAARARAHAFWRDVEDLGTELGNVLRLGLGRGLNRGVGGVGFNGVGAGGAGGQRKPRKRRRWIWMKIRIGRFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C825</accession>
    <name>A0ABR3C825_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617183.1">
        <property type="nucleotide sequence ID" value="XM_066755282.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987575"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="9">
        <location>
            <begin position="146"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1534"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1617"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1621"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1661"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1683"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1729"/>
            <end position="1738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1738" mass="192086" checksum="70D0373E2EB41B7B" modified="2025-10-08" version="1">MPPTQRHPAGINPYAAPHPAKQQPRNQPTKPPHRPHPPRPSAPCAKVENFGPPAWRTVLHNRVDFGYPDFYPSRPGFHQPEDVLTEENVKSGFAGRPFVSEVAETFSMHGPIHQHLSGGCLNMLMQLGKDLVEKQEESMPQFQERSFRIPGRVIYTDNKRLGFLADLGNPDIPLHWLMRNQIPHGFKGVELLDVMFSPLTTVRQPPPNLAPMDPIPIDRAIWLIRVIGSNDIAAHRARQHQTATSVPAPSPAAATPSSTTTVTATPALPVSSNDWYSQEFTNTVISWLRIQLGQLALPNTVKAAGKLPVTKAASGILQDEKARAKWLAKWDYSTRLLRALHTKHLISTRLFTGWLADHLTHVNLAQLGFLAQLIGEYLDDLVRHLGSARHCLRAACDKLVEVRNSPGKELLAKVETMLITIIQSLYEANPDVLLSPSTWRQHSPLLAAILPSSSPQWENLKRRNEALTFKPTVSAGSSNPRRQHMAEIQKLDSICEDTDMRQLTSLFFDGAASPTCSPVDLVKFEEKVFTLLNWSMGLYQLGGHRPYAVYTLLKHWHEQQEEHQQAAAAMSAASSHAKLAKRQHIDLFEVVYKWLDTAPAARNQDNVRAIGITIGELTRRGMFSYGRYLQTLIANGQTARNLRSPSDKRSHHLALLKSMPIFVMAKDLFQQRRIALSGDDLEVRRRDELEEQGVLAAFEERVKEYVPEVYGLKSYGQSEALKTMVHYEIPTSSQLTRYLYVYARFSIAANAGAMLKSDGERPAMDASTFARVTQVFRQSHGYATIADFMIRALQEAEDDEILDVILDIIKRDADVWTAMDLWPRLGDKLLDRHHVLERKGKEHPRLMQLLRVLAQKKRLTPDDEDEVEQLQTSIDKSTTPPGGIKLVDIFEVLPHILTTGKESKAISVAPALFRQCGSFSSWSLKWWMLILDVVQKANTAQKPFLYHVISTHLSAVLGQHGDSLDDAVTSWFENLSAVNLVETFGKRSSGVLVRLLLFLISHRFLSTWVLLEKAVFPIWKHASPFALPPRKRLSSKQIQAITSTVNIIAQLLISPPLIPDFPPVSLKESLIVQASRQPVLQRLSVGILIQHLPLLVVFEQSKLLPDQISQRIDAILRNLAMTAEFKTAAFRNLNLLKDAFLAREWSGPGMDQGLEGKMIDVLKRIMSEKPTQPSPKQGLPNFDTSARFSAWRWTRVVLEMRVEFKALTMRIAEGQNVAEAKQTLNQLVHATLDRETTADDTDLLCEVFRGVDSMVTQEILAAGLERLATLLGHAIAAESQQQLETNIKSIDQLLRILDSMNNLPSQSVTEASVLNARHKLLDLLALALQTVERNLSTTRDGSDLLLPPGISPPQPSHLLKAVMGLLKFTLGSVGSENGSLAAPKPNFPHLAVCFLKAVFASDGILDSSSAKIMADMLVYIIDCTSPQARLICQSALLAETASPHAQSILSSFPELSAALPYLSPVQRHMSLVTPDTADHISDSALPLDDRHWELFEYIGPPKRKIGPQDLFLASAPLKDASSIPITLFDPKITRDAPPNAGTMGAYDKPAEDGEMSPTVNSASPVEEEQEPRRSWETFASERNLGDGLAGEPAYAKQAATLVFSARDNDVPEIMPVKSTASQQPVVVVPSSTSPQKPKGKRSNSSGKDKVTGSNKDAPIAVEEDENDEDSEVEAPLSKKAKTAKNSAAGSGKSTTTAGKAPARKTTGGKGVSKKSTGKSAKESGMGKAKGGRRKSQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C902</accession>
    <name>A0ABR3C902_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617231.1">
        <property type="nucleotide sequence ID" value="XM_066755330.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987623"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="310" mass="35670" checksum="82A8C9F8DC0A7BCC" modified="2025-10-08" version="1">MRYPLTSPPPVTSYPFSSSPLNPYTHPHSITSAYPSMPSSSSSPPQSSPTPCLRQLPHPTPLFRSSPVPGKGKLLTRYQRPARKSLPSSLTTGPSDLGTRDTDLFSEGTTPLEGAMWRERFSRRMEERERRRKARNANLNRRRGIDGLGLSGVSLDEDEAERKAQEDDEEIFRRIVILQRKKANHAALVSEEQETGGLDPNLPDFWEEELEAMKNEERELLRRLDQHVEDSPWIERGEIEEDIWAREAAEAEEVEREAEMARMMEEYERNALSGMRNQQRSQPSQKQQHHAAGDEDMDVDWKQFVRMDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHW3</accession>
    <name>A0ABR3BHW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610805.1">
        <property type="nucleotide sequence ID" value="XM_066760980.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993411"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="43"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0240306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="354" mass="38502" checksum="242ABF6E316B8CE1" modified="2025-10-08" version="1">MASVSHITNADPFRLPRKPPRPFVSAHHRSPSRDHTTTDNIFRVLLISSGSVASIKIPNIVEELVKAGNIDIQIIATKASTHFYTQADVDRSVQSALNLSDEQMQDDVGVRIWTDEDEWSDWKKVGDPILHIELRRWADLVVVAPCSADLLAKIAGGLCDTLASSLLRALSPSIPVIICPAMNTHMYQHPLTAKHLAVMQDELGYIVSGPQGAGRLACGDDGPGKMTDWHDIVSLIQGFATMHQTQALSLASLPIPSLSTSIYRGETSINTSSSPSASAHTSTHNPPYRLPYELSSNILRQKERGEGEHPTPVVPLPDLHPLSAEAALNGKKMPASVYAKNLDWEKLANDEGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI77</accession>
    <name>A0ABR3BI77_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610799.1">
        <property type="nucleotide sequence ID" value="XM_066760974.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993405"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TECPR1-like DysF" evidence="6">
        <location>
            <begin position="106"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="503" mass="55666" checksum="1387BA07E41D16C1" modified="2025-10-08" version="1">MSVPPYIASSVPPSAILIPSPSAVDISASPTSSNAKPHLPFPPSSAPRGKPTSSTLGMSLPSLSSNVSDMLLSSLLPPNLPKLPSGGARGIDGGGPRQLTTQREALSVPLLSNNFRRFVTRVGPVFWLQDRIEEVLYWRKPVWTWAWILTWVFISTARVHPPSSTGELSPDKSYTATATRDESGETVSVPVVPPKEVESGVDYFMNIQAIQNLMGLVSDGYDYLAPILSNLQSPNTSSPTSFPLTHTHIILLLLPPTLFLPLTPSWLIPYLILPLGLLPPLAFHPNLTPWLLSLPRHPSIRKTRSVLEKWVLTDRLPDKYCGSKISQVYVWENERLDPKLASSSSSSTGPVPPTSWSARFLRQGDRRAWIKIADVAEGEECLWKSVDDTDLPNGDDESEVEAKVLALKDGWEWLPEDWKVDVNGLWSENGVDAEGWLYTDDSWQNPSPRPYTEPDAPANSSSIPGQSAQSVQTGKEKDMPGLGLRRVTRRRRWWKRVYEATFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIA4</accession>
    <name>A0ABR3BIA4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610927.1">
        <property type="nucleotide sequence ID" value="XM_066761102.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993535"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="188" mass="20917" checksum="762C76484DE74543" modified="2025-10-08" version="1">MQYSDGSLPYFELAKTFNQASPSRNISRQSFTDIWAKQINRLTNGPSPAWLCFISSVTTETFTPEPWPNHTRLLYRPPPTHTVGHNLVVSVIIKVPRREMSCSANIKRTSPISTGNKDNSILNKRRSPPSMPDWKKPNRSSTRISSPLLREGRGWNILISGVWMIAIGVLLVIIIGGIVASAIKASHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BII3</accession>
    <name>A0ABR3BII3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611003.1">
        <property type="nucleotide sequence ID" value="XM_066760731.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993153"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF2">
        <property type="entry name" value="AMIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="75"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="556" mass="61614" checksum="6B751A7825A707CB" modified="2025-10-08" version="1">MSWKEAVEIKRKERESRLPPKWLIPSDQLPSSDALNVQNLPRTLGWLSDQEIEITEASIPIILSRIANRQWTSREVTEAFAHRTTIAHQLLNPITEVNFEAAFAQADDLDEYLAREGKTIGPLHGLPISCKDSCDVEGLDTTMGYSAWVGSKAKKDCVMIASLRAAGAIPFVKTNLGHTLMMGESVNHLFGRSLNPWNRSLTPGGSSGGEAALLAFRGSPVGWGTDIGGSIRLPSASTNLYGLRPSPGRVSYRGLADTFLGQEAVRCVLGPMGQSPHDLELIMSVYMASKPWNKDPDVIPLEWKKPNDALADRPCCFAYINGDELVTPHPPIQRALNHVIDKLRKAGHHVVEWQGPLAKDAARLMLDFWTADGGEEIRRRVAASGEPMIPEVAQLLRMTPSSNFIPPTVSQTWKNQHERDLYARQFLDHWQDSACWSGCGEIIDGLIIPAAPFLARPHGADLPNSKWGVFEHTYANFQPLFQLSTGSFPSGLFQDPSIDLPLKEFIPRSDLDKVVQALYSDPEEWQGAPIGFQLVGRRLEEEKVLAMLQRVKEALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIZ2</accession>
    <name>A0ABR3BIZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106457</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611157.1">
        <property type="nucleotide sequence ID" value="XM_066760885.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993312"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="135" mass="15888" checksum="9690528CACF6A450" modified="2025-10-08" version="1">MCKHILNAQVAIRAPCCKKFFDCPQCHAESQDHPLRKTMEMAFLCKKCKKAFRKDMTEYEEADEYCPHCDNQYVIEAKEPQAMIGVEGEDARIDNRMLKDDRVKEKPERSLFAAQDMSNKLDRMPLFQLNPKERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJC9</accession>
    <name>A0ABR3BJC9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_106607</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610855.1">
        <property type="nucleotide sequence ID" value="XM_066761030.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993462"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0240356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="478" mass="53548" checksum="C1DBD3E2560700A9" modified="2025-10-08" version="1">MADLTPGPRKPPPAELTGFRSALAHTGIPHGVLLWKPRLPSRNWLIFWSVSLSLSYAYYYDRSECKRIKQEVVERVEKYGREPMPGGSLGEPRRVVVWAGRWGGDDDADRSGRYFRKYVKPYLVAAGIDYTLPSAPLHGSITRQVHAAILLQRRQALGLAPTAMPLSLPGVLDPAEVKRREVESGVVLVGRASMKEYLEGLRRGWEGGVDEWEWEKEVEKTLEHDGVFDEPKNVADAADAAVDAAAVDSNVETATDAAVPIAAAPAAPRSSFAFLSRPSPPAPATGPGTPTPVTPARLHTPPSRLPPTPPVLLLPFTNHLGFLQLPYMILDFFNERAKVRQGAQSALALIEGPVTDMHSGDAEHWDEKSESWYNKTARQLPDRLHKARTEYYESIKSRIDLARAYENGDREMTDEEKKANKVERIQDIQAERLKKELRWRGSEEGWEIVKPETPATWRDNWEGWLKMYQVPEDAKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJU1</accession>
    <name>A0ABR3BJU1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611438.1">
        <property type="nucleotide sequence ID" value="XM_066760677.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993099"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0242056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="110" mass="12555" checksum="F748B2A2862E01DF" modified="2025-10-08" version="1">MPDTSSTSWLTFRFDRAETGGDHTATLTLYLPDPEVTQVNDVQSWVSHFERSGAVDIGGRRRIGLDTAIDLYVVPGNDDSRNFVRNGLITELENHYYEYWVPDPEFEGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJX4</accession>
    <name>A0ABR3BJX4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105725</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611479.1">
        <property type="nucleotide sequence ID" value="XM_066760175.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992580"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="61"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="556"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0242097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="592" mass="65106" checksum="3B6A8305F397B945" modified="2025-10-08" version="1">MSAVDPTNVVHEKHERPEHLSDADNGTIFSSNGFRLSEEDIQAARDVRPSRVSGKGLTWMVTFVAGTGFTLFGYDQGVMSGLLTLPSFEAQFPNTAGGFEGSRTATLQSFMVAIYEIGCMMGAISSIWIGDRLGRRHTISLGGLIMLVGAILQTAAVDYAMMLVARVVTGVGNGLLTSTVPAYQSECSKPHRRGQLVLVEGSLIAFGIMISYWMDLAFYFTSGSISWRFPIAFQILFILIMVFCMYVFRLPESPRWLAANGKNAESLAVLAALSNTTVDDQEVMNTFHGITDTLAAENSGSFKFSEIFTHGKSQHFRRTLLGMAAQCFQQICGINLITYYLTSVLSRLGLDAVMSRIISGVNGTCYFLTSLVAIAIIERAGRRHLMLWMAGFQAVTMAILAGLYDLSTNEENPNKTAQVFSVLMLFLFNTWFSVGYLGMTWLYPAEVTPLRVRAPANALSTASNWVFNFMVVMATGPMFANIGWGTYAFFAAINAVVILPSVYLFFPETKRYSLEDLDIIFAKANTEDRSPVRVSLHPEEIPPAGSREAEEILGRAPAPHIKSRTSHGNMITRALSRTSESGKDRDQHHETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK71</accession>
    <name>A0ABR3BK71_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066761140.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993573"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29590" checksum="20DD828AB173FAFE" modified="2025-10-08" version="1">MASERTYQLAVHAWNTYHDTVAIQSNTGLAIAFFPVPFIRNRGDNTWRYVLQVVNQLVESHAPHIGVIKNLEGEVLDSEAAPLSGTYLYEQTGCTLPLKFSRGPEYFTAVGAANTEGSSTRARSSRSTVNNQSSFLLNLIARDTFRPDIYQALLNIPASLPPPLFEVQFGLLLRKELHHAWDRLDFSFFVKDDDIFNLRPVIAGLPMLFGESVSQLSAPLLQMNPLSRFTVECFAHLPGVLVVDTQLLCILSYRKGRIAASYKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKI4</accession>
    <name>A0ABR3BKI4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611666.1">
        <property type="nucleotide sequence ID" value="XM_066760362.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992768"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="193"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="7">
        <location>
            <begin position="789"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="604"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="709"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="827"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="618"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="850"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0242284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="866" mass="95362" checksum="DEDE25C187FBAC9F" modified="2025-10-08" version="1">MYRPRPRSRSPDRTQRAYSPSKPLSPPPSRYDRRQPRRHDDYPPYPAPDSRRYGDYPPEMSDYPRNQSMRYEEPYYQRRHEEPYPGNRYMDDPGYAPPRRERHEREYDDWGSDGRGYEPRERDWERGYERGMAIDKEEFPSRRDVDPALEQWERGRDPDLARYDAPYSTGPASDLANQPNHGRKGKNPSEPSMDVIFLGLDPELTEDDFLGYLRTEHKAAISGVKIVRDKFTGASKCFGFAQFQSLDGASDFINNNFPTVLMPALYAHSDPRKVKIDFSTPQQNPHSGHGSYQSAPVYVRPGHDGMRDIGSPGGGKRVLLLRGLDSMTTPDEVIRRIGQEIARMVGKQGRESEAESSIVRVVLIVDKSARSSWGYGFVELATSELASALLPFLLSPQHQPTGFLIHDVPVAASFSNPSSFVPISAGPLGGEFIIRPSRLGGFGSETIDKSEGQWCAYWHERGGVMESVPRGAPAINEDGNIELTPAHRAFLGSLAGVPQSQAASSQGSNSVQTTGMTPVSVEGVMQPIKIGMGKAKKKEEAAIIPITQKRSLLDDGEDEDKVGKDTVLLSRTKGARIVPPTSSSRKIANNINKWNTKQSELAVPDPVSENVPPKGISDANSAIGTRRPVNTESGSNPAQPSVMPASSPAVLPPAAQTEEFDYTDVSTFETTGKVACLLCQRQFKSEDILRKHVAQSDLHKNNLQDAATCQAGQRRKGAISSSTSTPEPSTSIYRDRAAERREAFNQPAVPSRAEREALAASTAAYQGKRKPPAKPKQPPPPEPSKQTEENNVGNQLLAKMGWKTGEGLGLAGEGRAEPIKVQQFESRAGLGASKGVEAGRWSGPGGWQQRAKDMTKERYNSESGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKK5</accession>
    <name>A0ABR3BKK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611702.1">
        <property type="nucleotide sequence ID" value="XM_066760398.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992804"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="290"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="534" mass="58331" checksum="DC60B7EF66AD3D20" modified="2025-10-08" version="1">MPGNSQASTDLNTDASNEEELDTETKLVLLASLVHPLTLPPQALEMLASVGGDVAKAAEKLLLPSPKASRKRKAGSSLQEWLGRPGDNNKAVKAKGKQEAESTGRHLTMSAAGTSKIRGISIASIDKDKESDVTLSEATPSKPVTNAFDVLGRTPSSPVKQKLGPQPPVRLLSQASIDSHSLPLTLINHPLPPSLASALYLLMLEEAESWGANRFFIAGKEAKSPHKTGFYRKEGGGYGGGKYYYAGVEQGPAKIYPALLTRAAEIVEKIVNEELRKKPRYGPEWGGEWKANACGANHYEGSRSSVGWHADQLTYLGPYTTIASLSLGTSRAFRLRETPPSDPAFIINDKPPCTYEITLAHNTLCLMNAGCQERYKHTVPPQKAIDLFRPGYDIEENPIPRDVQQAFTSRINITFRFYREGKCNISADTRLCQDFHPVPIAGPSGPREGTPICRCGVPTVLRADQKAKARSRLSSTSSRPRLRASNIMNIIEDDMVFFWQCQSATQTGVGRGCGFFRILDMKKERRGPCIGDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL46</accession>
    <name>A0ABR3BL46_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611876.1">
        <property type="nucleotide sequence ID" value="XM_066759930.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992330"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="135" mass="15244" checksum="FF06CB94887A2A5C" modified="2025-10-08" version="1">MGQHRHIAAQEDNNGTSSSLRGCMLEAIRQWPVPFAYIPDEIIRLPTQPPMAYTGLTEGVRKSPIGSAKSMGYWTHYAIDRYLPLPALWSNTFWDGNLSSGHLNGFRVSQGHIDIRWKRAHDQDLPMLGPCDQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL56</accession>
    <name>A0ABR3BL56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="3 7">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106723</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="3 7"/>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610683.1">
        <property type="nucleotide sequence ID" value="XM_066761143.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993576"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="9">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="10">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0240175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="380" mass="42258" checksum="F5C73FD3D571A429" modified="2025-10-08" version="1">MSHAVPKLDLVNSWRDIQFPPLKNDLLLRAANGEETPRAPVWVMRQAGRYLPEFLEVRKHHSFFECCQTPSLASTLTLQPIDRYPRLDASIIFCDILVVPQALGLEVLMEPSRGPVLPNPLVTPDDLKRLREDVDVQKELGYVFEAVTLTRKGLDGRVPLIGFCGAPWTLMAYMCEGGGSKTFEKSKSWLYKYPEASHELLRRIADVCADLLIGQVLAGAQMLQVFDSWAGELTPHQFKTFALPPLLHISSKVHSVLSKLSHPGVPITLFAKGANAPSTFSLLSDPAHTGYATLGLDWTVDPVEVRKIVGKKVNLQGNFDPTVLYGGKEGIEKEVERLSARWKEAGGGWIANLGHGITPNVKPEDMGWFLECVHKYSERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL84</accession>
    <name>A0ABR3BL84_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PIG-P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611894.1">
        <property type="nucleotide sequence ID" value="XM_066759948.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992348"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9825" checksum="DEDFBC6832737DEF" modified="2025-10-08" version="1">MSETPPSSPIQPLSPLTPISPWPSIPSADECPLSAADTHGDSLPNATDVYASIAILGTYLSFALYLFWATVPPKWGWTSWLPDREWTVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLG0</accession>
    <name>A0ABR3BLG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611623.1">
        <property type="nucleotide sequence ID" value="XM_066760319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992725"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37772" checksum="99EA03A81BB2815E" modified="2025-10-08" version="1">MPSFTIPLLLLGALPLILLWIPTWIEPYSLWDPKVLNSLDGSDGRITAWCNMGWWKNTDIFPEAAEALAGKLLELAQQGGYQGGGNVLDMGHGAGESLLLHLSQKNPPSQLHALTSLSSDAAVSKAVVQSTYPNTSTHVEFYTFSAQFRPGKDVGHPLDPMRGFLGEQSSQRFFEDDESTEGEDGADELQEDRPQSSSKYDLVYILDSIYHYPPSLPSFLASLRKVLHSSSLVVYTDILPPPNLSKVNTYLLSRLLSVPLPNLTSQPRNLGEYKAQLETEGWEDVMVEDWSDGVWNGLSSNLKARGRMWSLVGRAIQVAEENGWKFIGVRARKGDNVHNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLK5</accession>
    <name>A0ABR3BLK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_105644</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612042.1">
        <property type="nucleotide sequence ID" value="XM_066760096.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992499"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0243675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="95" mass="10605" checksum="51CC9E016DA29B3D" modified="2025-10-08" version="1">MASGFGYTGGRTRCFPFWQEFSKCYANAEKPSDCVAPKDDYMECLHNTKEIARAKEVKSHFVQKELQESHDSRKAAEKAATGVIVSLGLVEEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLN8</accession>
    <name>A0ABR3BLN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105987</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611740.1">
        <property type="nucleotide sequence ID" value="XM_066760436.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992842"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045007364" description="Peptide hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="101"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0242358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="402" mass="45700" checksum="DE9CF6CB57B4D62B" modified="2025-10-08" version="1">MTAFLVYLYGLLILSVSAYQFRAHNPLSSSQLKRVIELDPPQFSSVTDGHLGKLLIPRPSGSENNTLVQNYISSVFSKLRWHEEKTPFTAATPIGDIDFANLIYTFDPDAPRKLVLAAHFDSKWYPDYPANQFIGATDSAAPCAILLSIAEFLTPLLNSRQSRISSGQPFLRDGFDEEEEAETTVQIIFFDGEEAFHDWTDTDSIYGARYLAEEWSETYLPPAHPLTRRRMHPHPTILSTIDHLVLFDLLGNKHSSIRSFFRETDWLFDRLASGDERLREARLIEVEKGEDTWFRTEKGRKGMVGDDHIPFLDRGVSVLHVISTPFPSVWHTIADDTTALSLPAIRRWNRILRVFVCEYLSLFPEDMGMSLDRDIDMDKDSVVNGLSARTISAAKTKLQNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLV1</accession>
    <name>A0ABR3BLV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611971.1">
        <property type="nucleotide sequence ID" value="XM_066760025.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992426"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="93"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0243604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="528" mass="58247" checksum="5BCAD502D6AB80D5" modified="2025-10-08" version="1">MLEPVEAEFAKPPIFSNQQEDILREEEIEEPNAISDAGKQATSGSDNSTLHGHQSSEKINEKDVEKGKDEHIIVQFDEGEGPKQWSKGRKWWATATASILCLAVALGSAMPTGDLPGTAKTLHVSDEAIYLSISLFVAGFGIGPLIFAPLSEVVGRRPIYAVSMVFYFLFTLPSCLAKNIATMLAGRMIAGLASSAPFTNVGGTISDVWAVEERGFPMAVFSSTLFMGPCLGPLFGGWIAEKTGQWRWIYWVLFILCGACVIFCIFTPETLAPVLLRKKATRLNKENNTTVYISEHDLHRAPFKETIKVALTRPLIFMFQEVIIIFFTVYLSFIYALLYATFFAFPIAFEEIRGWGLGMTGVAFVSIIIGIAIANLCMPIQERLYKKHCEKHGVVPEGRLYPMMLGALTLPVSMFILAFTSYPGIIWVGPCIGGIIFGFSMVIIYISGNTYIVDSYSNYAASAISAKNMTRSLIGASVPLWITQLLHNLKFQYGMLFLALFSVVIAPIPFVFYMKGAAVRKRSKRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM02</accession>
    <name>A0ABR3BM02_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612192.1">
        <property type="nucleotide sequence ID" value="XM_066759545.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991943"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF9">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0243825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="269" mass="28779" checksum="041E417893F12C41" modified="2025-10-08" version="1">MTVTNVATAHTTTVQNPRLRLLNTLRSKTPALMTFIAIPSVRHAQIVALTGLDGVIIDCEHGHIGDDQMHNSVSAISALGVSPIIRVRGPQPDILKRALDTGAHGLMVPMINTAKEAAAVVTYSKFPPYGLRGQGSAFPAIGHGLTTPEYMKTANETILTIVQIETKQGVENVEEIAAVPGIDYLFIGPNDLAQSLLGYTPARGDEPVFVEAIDKIVAAARKHGKWVGRLVNDGPLAVEALKTFDSVAITGDTKAISNWYTAQIECVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMB7</accession>
    <name>A0ABR3BMB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612136.1">
        <property type="nucleotide sequence ID" value="XM_066759489.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991885"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="144"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="290"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="605"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="656"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="786"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0243769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="882" mass="95198" checksum="4B0DE1739E26060B" modified="2025-10-08" version="1">MPLSVDPHPHLHAGYYSPSSSSSPLESNSFPTVGPDPDDTATGDDEDNMFRDMSFDEILEDLNARFLINLPKEEMNLLRVYWQAEQAHWFYEDYLRPLNPSLPSLSQRQFTRLIIESSPLYSRLVSGSAVDYESVWDEYKSYKRMVPCCGGILLNKEGDKVLLVRGWKSNAGWSFPRGKINLAESEEACAVREVEEETGFDLTGMVNPDDKIKTYISAQEVTMFIVPGIDEATAFETQTRHEIGAIEWVALQDLPTWSGNKRGPRKTGKAKRFYNVTPFVNPLKSWMKEHGMNPYPKARQSKPTSKSTSVFHRDIQPFQFDSFTGSPSNSPVPEASTPSRLPSRGSSALDQLFTKFIHKQEEEIMTPSRATALGSDNNAGLERLFGGLNVLQEEEDALRQRQQTEEEMRKKEDDALARLLGGVGGTTPQQEAPQPQPHSQIKTAKQTNLLAMLNQKPSEARFSKAHASTQTQTQVQPHHNKLLSLLSPHAPPPSLQTNIATLSGSGVEAEIKASDAGVVATTSPPSARSASGIKNERGETERQARARALLDMTVAGIGASPATATASVPTTAATVANAKAQTVGGQGKQVSSLASFGVNPYAPYPPQPPYPSHPSHLSHPAPPAHLTHPFLPPHPGHGRANMNLNMNPNATQARPPTIPPPPMSMPMPMPMSLPINHSYRPPANGPHPHLSPPQSMQGMYIGPGGPEGQRLAQVPGQGQGQQGQGYYQTLPAGSSPNAQMGPQPISISMSGLGPGSGSGPGVGPGQGVGYYNSPPVSQGPGMFPHQVNGNVNGQQQNQHPLPMLPLQNQALLPQLGQMAQYNHVEQVGQNGQNGPRTLPTKASLNGVQAQGQAAANVYHPIPRPPVGPAGLLAMLNGDRQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMG2</accession>
    <name>A0ABR3BMG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105706</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611460.1">
        <property type="nucleotide sequence ID" value="XM_066760156.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992561"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="16"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0242078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="539" mass="58957" checksum="DC00CEB60EE4CCDF" modified="2025-10-08" version="1">MLRNTLLKGRAVNWAITACCGSAFLLFGYDQGVMSGLLTGSAFTQQFPEIDTTDGGSGSASLQGTVVAIYEIGCLFGSLFTFFFGERLGRRRCIMLGCTVLIIGATLQTASFGIPQLIVGRIVTGLGNGVNTSTVPVWHSETTQATNRGRALAIELAINIFGVMTAYWIDYGMSFVNSAAQFRTPLAIQLVFAVVTILLVLVLPESPRWLLKHGRGKEALEVLNQLSLATGDVRTDSVNLEYAQIQHALEEEMAATVRDKNGNPISAVRACFTSGKERYFHRVMLGVGSQFMQQLCGINLITYYAPVIFEQSVGMSHDTSLLVSGFNGIAYFVSSLIPIWAIDRIGRRKLMLFAAIGQCACMAILAGTTSVSFKATGIVAATMLFLFNFFFAVGLLAIPWLLPAEYAPLPIRASAAALASASNWIFTFLVVEITPVSIKSIGYKTYIYFCVFNACFIPLIYFCYPETAKLSLEQIDLLFTGEKVLRVLPHELRNLRPGEEHGMVEQEIDSTASVDDKDLPVTIEHQGPIPFKKEKREKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMH6</accession>
    <name>A0ABR3BMH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611475.1">
        <property type="nucleotide sequence ID" value="XM_066760171.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992576"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="18"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="314" mass="34531" checksum="186E749BCADCFB3D" modified="2025-10-08" version="1">MVKKFVVDKPLLELNGTLGEGCVWDTRTQRLYFVDIDQYKLYTYEPSSGKYGYETFDKKVTALASLEGGEGLIAAVEDGFAYVSFDSLPFPPTSSKQSLISIPSGVSLNSKEKRFNDGAVDPAGRFLAGTLGFEHGSKNGKMYSLQAEKDESYSAPLILDGITCTNGMGWTEDAKIVYFTDSWIKEIAKFDYDITTGKLSNRRVFSKIEGYGEPDGMCMDSEGGIWTCRWASGKILRLTPDGEIDVEIDFPTAWHITCCVFGGENLDELYVTSAASDYIGDNLPDRKNGGDLFVVKGLGIKGVERGRFKGSIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMM4</accession>
    <name>A0ABR3BMM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612256.1">
        <property type="nucleotide sequence ID" value="XM_066759609.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992008"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="98"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="537" mass="58679" checksum="64A7A8DC6B0CF5F0" modified="2025-10-08" version="1">MTAPRIISRIAARALRRSPLHPLPRSTLAPTKLSPTGYTYVRLGSTLPPRADFTKPTEEHIKELRTFLSSNASLISTIDGSATPDELQAFNDDWMNKYHGKSPIVVKPKTTEEVSKVMKYCYDKGLAVVPQGGNTGLVGGSNPVHDEIILNLSNLSQIRSFDPVSGIFVADAGVILEVADNYLAEQGFIFPLDLGAKGSCHIGGNVATNAGGLRLLRYGSLHGTVLGLEVVLPDGTIWNGLSKLRKDNTGFDIKQLFIGSEGTIGIITAISILCPRRPSAMNVAVFSLPSYEAVQKVFGEAKTYLGEILSAFEFFDKQSYALVKKHQEENGETRSVFEQEGDFYCLIETGGSNSEHDEAKLTALLEHLLTSDLVLDGVLAQDSTQFQSIWSLRELIPESAGKTGSVYKYDVSVPVGKMYGLVEKMRERLRKEGVLEGDGNPEGPIRAVAGYGHMGDGNLHINIVANKYTEEIEKIIEPYVYEIVAENEGSISAEHGLGVMKAPYIGYSQNETSVEVMKKIKNLFDPKGLLNPYKYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMQ8</accession>
    <name>A0ABR3BMQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612443.1">
        <property type="nucleotide sequence ID" value="XM_066759796.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992195"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22748">
        <property type="entry name" value="OTU_OTUD6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="184"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0244076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="351" mass="37201" checksum="49EB4764FEB7F341" modified="2025-10-08" version="1">MPGSKRRALKKLLSPSHSPFTSDSPADSTPVPAVSPQPELPPATDDAAAAQVAAAGISPQEIQDNVVLEEMHEREKEIGHATSPAGLGGVNSSSSLSVPVQAQEAKSGGMYGGGMYANSNGGGSGGGGKKKKSSRQRFEERQARKQEALLESAPPADPDWTAQLEKERQEEIKVITDACIALNRDLFEIAPDGHCMYAAIGDQLGLLGIISAEEAAEPRVIRRKAADYMLSHPDDFMPFLPSTAGEDTPDATSDGMITPSGFEQYCKAVAETGEWGGEPEIQALSRAYGIPIHVIQRGPPTVVSHGGNDDSFGGGLTAEESAKQGERVVRISYHKRMYGLGEHYNSLRPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN36</accession>
    <name>A0ABR3BN36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">P115 like vesicle tethering protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612562.1">
        <property type="nucleotide sequence ID" value="XM_066759075.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991465"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="5">
        <location>
            <begin position="428"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="6">
        <location>
            <begin position="1005"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="903"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1104"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="923"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1032"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1113"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0245478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1123" mass="122891" checksum="BCB524DCBFDC3F68" modified="2025-10-08" version="1">MSTQQFTSLFGSRLSSAYNQLRGDLGAPQTATDTVAKLVDKIQTSAAVEDRRTAVLGLKGLSRDWKEDVGRRALPSLIAVLEHDAPFDSEIARATLETLMQLCETVEKPTKDDLGLFFTDAFLEVPKPLHTLVNLISASPSFYPRYFAVQFLIQLTTARPTVAQSYIMSSPPPGIDGILAVLDTNSSSATPSMMGGGATEMLRNETLLLLPPMLAGNQDLQKIVAFSGAFEKLFQIIDQEGGADGGIVVQDALAAVACLLRFNVSNQNYFRELTLIPQIPRILGFPAPLPADEPTPDEFALQYWSDQKIHNTGLVLGLIRMLVGGPGGGNQTAMVSSGVTRCLLELSLASNAPPSIKSQCLSTLTPILTASSANQDLLSSLLLSPLLAVQADNEHPGGGFVRVPAKPAVEALVASIIDGDPATGGKGLKARAAGINMFDAYLSSNDEARITILSTLATPGADNPNAEPTSNAGSLILSGVLGLPHSSITPSFDPYRPLFSCLLLSHLIRNSEHAKKLAREISFPSGDTDPNHDPDSAVEAEEDEIPLLQLVVGNLMLASREQTESVNRAARDGGVEAAREEEEWTRVMVGYLALLCTWLWDSPKSVKEFLSESNNLQALIQPITQNTSIDPLVQGLSAFLLGVCYEFNREPGEITRATLHPILHSRIGPDQFVSRMARLREDPRFRAVQPDDFELTSLLSGQPTMEDEDEENMEVWFDWAFVDFWKNHYYTIQRSIAIDPDVPRNAPLADDAETAAIIMSLRSKLKTQTDEVTNLTNKIESLQKEAKGEKGQLIEEVESLSSQVASLSTQLGESVKRAEELEGELNTLKQSYADLEKTAAAAQSTATELESVKEELKHVKEAHEKASSELSLAKMSAKGREGKFKDLENKVKTLEEELGEAVKANKVTEAGPPAGTDVGDGANKAEEDLKRLEKENEEKKEELKKLEEEAKKQEEEAKKKEDEFRKKEEEAKKKDEEWNTKEKEWEAKIKAGEDRVKQLEENSMSSEEKAKSAEEKTATLESKIKELEEKLATAASAPAPVPAETTGGSNKQAKKRAAELDAKVKELEASLAEEKTKREEEAKEHEDLLVLLDELTGKRVRDKKLMKEKGLEVSEDEEGEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNP0</accession>
    <name>A0ABR3BNP0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612772.1">
        <property type="nucleotide sequence ID" value="XM_066759285.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991678"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="2">
        <location>
            <begin position="34"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="573" mass="64358" checksum="D6E23917FF0868CC" modified="2025-10-08" version="1">MSKAGSYFKTAMSLVTTLEEGKPHSSVTDWIEVLSSDRYEELSLDGISELVDSVNILGPQGTTEASRAIRKKLKYGNVHRQIRALVILRALTENAGKGFQLNWANEQLMERLRLMATDQLLDPKVKKMLLMVFHSWSLHYKDEPRMHEVAGLYRKYTGHGTKPVARKPSITSSTTATAKQGTFDNDIFSHDWNPAPGNRGADTYIDLAAAKADAEERKRAREARIALEQREAEVERRERELRRKRDMAEIEERRRKAAAEEAENRRKLKEQGKKKNQQPKRPPFNFEKEKPQIMVAVANAIQCANNLVNACRLVNREVENVTESPKVQDNLDKAKVARRSIIKYIQLVTDEEYVGTLLDANERIVEAIQLYDRLSKPAVLDSDSEDDAADASTLHKRLAAQKLEADRTGELQKIQENQKRESARRQQRQLLRQASEVGTPVRSAPQQASSAYSDLQDLDFGSIAHTQANLPPPMRPDSGDDDSYGGSLSDFSDYDSSDAEWQAAHGSGIVANKKASTAGPSSHVTREYASLEDDFSGKSGLLAKEDDNPFGDPFADELDTPVQEKQRLQWAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP73</accession>
    <name>A0ABR3BP73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612929.1">
        <property type="nucleotide sequence ID" value="XM_066759442.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991838"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0245845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="287" mass="32302" checksum="5FE12B5C3781808F" modified="2025-10-08" version="1">MYTHNSIDAPPPPYTPLVLSGRTSTKPSLANLPLHVVHRILILTLDQKATPSKFWSDPEEERVRRLWGMFRGLRGVNRVFWLVATSILRAHYLPFYLALVKPLYSSDPFPFESSSLSSPSLSIDPSDLGNVYAMRGRETAVLDKFVATRVGEELRRVESELSEGSEAERDIFGRLQPCARSEDLLSTLPQTLITPITLLPSPPPPARALPLPQSLLSINLTPAWAQLYINASPVSLTKIKGGREMVLEIRRLDRERRMRSLEETVRVIGEALEDMRRGLVEWGGRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP91</accession>
    <name>A0ABR3BP91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0246983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612944.1">
        <property type="nucleotide sequence ID" value="XM_066758496.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990871"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0246983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="530" mass="57361" checksum="125E49FF6D0CAA8B" modified="2025-10-08" version="1">MTAITDKSFPRTVTIQSTSNDSDPKKSSADERSLPAESTLGKIETPNRTNVLASLGPGRKNLLLLCFCLSMFIDAAGVSATFLMTAPIANDLGVKMGDLAWILGTYSLAFASTLLFAGRIADLYPPHRVYTFGFIGIAVFYLIISFMTDQYAFFVLRAISGLLAVMTIPSSINMIVQMYPEPNEQAKKLALFGVAGALANTIALVLAGVFLLASWRWYFRFITIIIAPFSVLAWFLMPPTEAVAEDLPGAAKLKRMDIVGVLLLLACLVLFILGFTQATSKGWDSAIFIAPIIISVFLLAAFLVWEQYVPRGYSLLPHDIWSFPNIFPLIFQASAVFMWIACAQLRLATFFQENLHDSAIMAAVKLLPMGIIALIVGGLTQAVPQLIMRPKYVQPIASVLCLAGSLLFAFSDGGPGDKYWKFLFPGQLIGTAGAMVIFVGMNTSIIQAFPLEFAGVGGSFANIIFQIGGVIGIAVQDGLVGTGADASTSWTGSRNSYFFTGAYIMLTGLVFLVWYRQKLMPKLEGPVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPK0</accession>
    <name>A0ABR3BPK0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613085.1">
        <property type="nucleotide sequence ID" value="XM_066758637.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991015"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="901"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="923" mass="101577" checksum="9A28B4AD10B6B335" modified="2025-10-08" version="1">MLSRIQLAAALVEYDNDDDIQVSNSSQSPRNWRDSAIFLPFIQAQQEERRRKILAQPPPVLPGFSCQTTGTSNNNEELPEPHLDTGITEDLEENIVDNGDIDVGDWGLPSHLVSEPNPPRPEHLRRRAISQPLSTLSDQNSSKLLVLDDLTEHGPQFGLRDDSGRRASLDQYKARQAWTEPQSLDPALRRHTAMCLPDGVRPESRSGRISDPSMIPSPNSHSLDSSSPITTLRPLNRNFATTSKQQLDTFGEREILNDSEPNLFIFPAPRPHSMSIFDPNSLAERRKPSFNSTNGFAFDSRLHNSLVLSSAAGPERSSTPLKIVNSLAESGQEYSEIPTPRQFGRPLMPPRYSTSAVTRINRSSLRPNVLLMPSPLADSEGSLHPDVKVPDGFVRGDKPLPAEAKTKGRRPGLPLSLSQKTFRSSLLVDGKRDYEEYFVGSSEIEGEMGVSSRDITIDAIQRRPGKLYGKSLIDELEARKAMMKGKQRVFTGDSRPAMMSRSTMFFEPSSMVPLSTGMIADPRYSTESRPSTFHSPEDRPLVRSDTTDDGQRMNPSDSNQRDTKGRSIFGVDHIWEMEMAKLKSMLDEGAGSGKIEAPLGNKEDKEIDTMVDFREKNGDTGCNAMARHQSTPPVASRQESSSSLGTATSLNSSMPGEEAQECSVSAEPEEAESILQDKHSSPLFEEYSDEDVPLSKIALRSTASKEGSSTDNKAGYTPSPSPPLTDSEEDVPLSQLALRYSRPSSTKDDVVSKITAPSRLQTSPSTDNDGYDEDEDDLPLAVRQAQAKGLAPPSRAEIIEDELPLGYKHVEAVQRQMAQRHTVGGMWGGIVNDVNHLGAGIGTHNPYMMWGAPGHLTTLGLPPALMSSSTPSMPNFNVSESKEIFSSCASNIDNWRHEVRPPSERMRTGDDGRDTRVIKHMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPN9</accession>
    <name>A0ABR3BPN9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613116.1">
        <property type="nucleotide sequence ID" value="XM_066758668.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991046"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21608">
        <property type="entry name" value="RRM2_NsCP33_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048289">
        <property type="entry name" value="RRM2_NsCP33-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="181" mass="18240" checksum="15E12266C545DBD3" modified="2025-10-08" version="1">MSASKVYVGNLSWNSTDDTLLQVFSAYGTVTDCIVMKDRETGRSRGFGFVTYGSPQEAEAAIAAMNEQELDGRRVRVNMANSRGSGGGGYGGGYNSGYGGGYQQQGGYQQGGGFNQGYGGGYGGSGYGGGAQGGYGGGYGGQQGGYEQGGYGGNQGFDAQQGYGGAAGGYGQQQGGYNGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPS1</accession>
    <name>A0ABR3BPS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM7</name>
        <name evidence="7" type="ORF">I308_104220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613146.1">
        <property type="nucleotide sequence ID" value="XM_066758698.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991076"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03223">
        <property type="entry name" value="Methyltr_EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="301" mass="33544" checksum="AEAA53E80F0E273B" modified="2025-10-08" version="1">MSQEPRVTSEGSQEEEEEDFFGLDDLLPEPESPLPPPFSFASYDIPTDIGLEVPDHRKSLILRLVGSHPLWGHHLWNTARTLSTYLLKTPQITQSRHVLELGAGAGLPSIVCALAGSSKVVVTDYSDEGLLDNLRFNVDVNLEGEEKERIDVDGHVWGQSVDPLLDHLPKGQKYDLLILSDLVFNHSQHDALIKTVEATLASSPTQLYDPSCPSATLTEPSILVFFTHHRPHLAHADMAFFPRLAESGNGWAYEKVVEEWAGAMFEDDPGDKRVRGTVHGWRAWRVRDGEEKGEKPSRVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPS4</accession>
    <name>A0ABR3BPS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="3">HMG-CoA synthase</shortName>
            <ecNumber evidence="3">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613147.1">
        <property type="nucleotide sequence ID" value="XM_066758699.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991077"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="5">
        <location>
            <begin position="185"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="5">
        <location>
            <begin position="287"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="502" mass="54145" checksum="38D513547A7D928D" modified="2025-10-08" version="1">MSNFDIPARPSNVGILGMEMYFPKRCISEEQLEEFDGVAKGKYTIGLGMGHMAFTDDKEDINSVALTVVSSLLQKYNIDPKSIGRLDVGTETLIDKSKSTKTLLMNLFAESGNTDIEGIDSKNACYGSTAALFNAVNWIQSESWDGRNAIVMCGDIAIYKEGSARPVGGMGACAMLIGPDAPLVLEPVHGTYMANTWDFYKPDLSAEYPTVDGPLTIAAYLGALDNAYSTYIQKAEASQARAAKKLSLASVTAAVSEVANGFVGAINGQANGHANGHANGHANGVSETKADGITKFDYVCLHSPYGKLVQKGHARMFYNDYLRNPSHPAFANVPEDVKSLDKTKTYTDKVIEKTFIGIAGDHYKSAVLPGKDCVSRCGNMYTASLYGALASVVSSAPEGIEIGKRIGMYAFGSGCAASFYALRVNGSTKEIADKLNLKARLASMDVRPCQEYVDALKLREENHNAVKYTPQGSLDNIWPGAYYLEGVDELYRRTYLQKPGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ15</accession>
    <name>A0ABR3BQ15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_104328</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX41 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613253.1">
        <property type="nucleotide sequence ID" value="XM_066758805.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991184"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17951">
        <property type="entry name" value="DEADc_DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044113">
        <property type="entry name" value="DEADc_DDX41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="211"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="407"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0247292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="615" mass="68679" checksum="3ADC45C31D5E7251" modified="2025-10-08" version="1">MVAARKRSPTPEAQDAFELPEDYKPYVPVAKRRAQMLSQLGAKHTAKKVKTQEELEKEMEEELKEQEEDEERAREKARRERTLLQAAQEVKEQKALEDAKKSAAEREAEKEAALLAEMERAQKKLAGAQELAQGVTWTESLKTSWRAPHYIRNRTEDEQQAVRDKHHIIAEGDDIPPPIPHFADMKIPKPILSYLQAKGIKRPTPIQMQGLPTAFSGRDMIGIAFTGSGKTLAFVLPAIMAALEMEARVPFVRGEGPVGLIICPSRELARQTYEQCVAMCAVLKEGGNYPELRSLLCIGGINMADQADVLNKGVHVVVATPGRLIDMLDKRKLNADNCKYLCMDEADRMIDMGFEEDVRSIMSHFKYQRQTLLFSATMPRKIQDFAQQSLINPILVNVGRAGAANMDVIQEVEYVKQEAKMVYLLECLQKTPPPVIIFSDNKNEVDDIQEYLLLKGVEAVAIHGSKTQEEREYAIRSFKTGAKDVMVASGVASKGLDFNEIQHVIVYSMPKEIEDYVHEIGRTGRSGKTGLATTFVNMNTSEQTLLDLKYLLMEAKQKIPDFLLSIDDPRAAHGGGLKGCPICGGLGHGLSDCPKLEEETRRKQAAQTRYHGGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQP3</accession>
    <name>A0ABR3BQP3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612288.1">
        <property type="nucleotide sequence ID" value="XM_066759641.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992040"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="82"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="484" mass="51921" checksum="643B7B09223CB408" modified="2025-10-08" version="1">MSFPQPSNDTASQHISSSAAPSSPHLIATALEKHDSAPERESEASFAISASTSQLTDENMLSGSAIVLFTPPIILQRGIFRGKQMRFALTVEQEPVLGRRKTEKDRRPLGPAPIVRLRAVECRSTDDDAQVIEEEVDAGTLDAVSIVCAADLCAPMTSRHSIIRETRGTKSFPESHRPHGKQGTSSVNFSGVTNSEQVSQGPSTFGQKANGKAAISEVDTMPSSSHGDVLLAKEVVREEKSAKRWKRRKSSDEMSSGSATETVRASRGGAGPGAAIPERNLYGSLHVGGVKVPDLEGKMGVWFLFTDLCVKQEGSYSLRFRCYDITAVEQGGSPVAQLAECRSQPFRVYSPRQIPMLPKLTELAEHFTRLGFKLNTRKNDRATEFPPPPPPAAPPTAHATVSNTDSRPQPCPVQPLDPASYISSSSSMSNSETAMKSTSTGQSTSFMTDSTSKTSYSNEEYGESGAKEASTGQLAADIGGQRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQV1</accession>
    <name>A0ABR3BQV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_103645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613534.1">
        <property type="nucleotide sequence ID" value="XM_066758132.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990501"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="9"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0247573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="174" mass="19512" checksum="1D2861E7D26E7372" modified="2025-10-08" version="1">MSRFSGRSLDKLWFAFFAFHLPISLLLDLQYLYPPSLLPSALKSFLLWSINLTRDPILLGVVNNDPTFGWLKCFSWLEAGFQVPCFVVGLWGLWNNDKRVYPVILAYGASTATTLLPCLHTILTTKATPPHSTAEIANLLAEYVPFLLLPLGMAVDMSWRIIKIISAAEGRKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRL7</accession>
    <name>A0ABR3BRL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103913</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613796.1">
        <property type="nucleotide sequence ID" value="XM_066758394.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990769"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="12">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="254"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="146"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="407"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="494"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="426"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="512"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0247835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="603" mass="66714" checksum="23D418DE57D9E0DD" modified="2025-10-08" version="1">MFSTAANPYDDLVIKATDENLASEDWALNMDVCDKVSSDGQNGARQAVTALQKRLSHRNPNVQIYALELANSLAQNCGKDLLGELSSRNWTSALDRLINDRATSAPVKKKALSFVKSWAKQIEETGDPNLGLLGELYDQLRAKNHVFDEPEPTPESAEEARRRQEEEELQRVLELSKQDKGGRAQFTYQPSGSAGASSSSVANHNTSYSSIPQPAAQAQVQPQAAPQATNYTPQPQRIYSPQPLEPEPPKVDLNTATRVRAIYPFTGQEVGELDFEKGDVIKVLDRGFKEWWRGACNGKIGIFPVTYVEALPEPTPKELQEEAQEEARVFASLGLVDQLLQTLKGIDPARGDKLDDRPEIEEMYQASVALQGQINTLIKKYSDQKAELEHMNANFIRAMGQYEELRNAPSPVQPQPFGYGPPQPQPQLQQQNSYSYQQYPQQPQQQHQQPYAQQTSSPAAQSQEPYTAQQQPYLAQVQPQAGLSAGDQQAWDQYYQQQGQQPPQPSQPPSQPQSQPQSQPQSQPQSQPQSQPQSQPQHPSHLQSQPQQGSYYPAQAQAQGYQAAYATMPDGRAYASPPPAGTHQGQGLEGVTAGMDRMNVHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS02</accession>
    <name>A0ABR3BS02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613924.1">
        <property type="nucleotide sequence ID" value="XM_066757540.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989894"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="578" mass="63838" checksum="D94907FF2E95AA03" modified="2025-10-08" version="1">MTCAPSFYNIYLLTIIHPLLIQNPSTVDVGSKDTTRFLKSEDQSGKRLYHEKLSQIIFSPSLFRNRSTPTRKSSRETSPSTRHYSSLGRQPEEVGILADALQGQLRIGSSEETEGTMRQLLRGLEDRGHLWEESMIAPHLQEDRSYRTKGTTITSSLRTNESVDLVEAVLKANDGAINDLWNLLQTAFGMSPSSCLFRRMINLLQAQKNEIHEMKPYIETKSFPSLLSLQQIYAKIDGNIKNLVDLSDTVVWDTLVTLVQALQEGSDYLTDACLICKIAWYAEMIDHYYATSIQHALDKAIDQKTDFTTYRRAAESILAISSTLSFDPLDDQMAENAYRDLCSLIRQLELRVKSNKTATPVTTAVHSVVDSSTTTGASTSTLLTLLGSLVDTPILSPPVLSSFSSCPSSPGASDFKSIDMKDLQTSFGTGVSTPARPLPGLSSFNATSTGIPAKPTPTPSSPAASVAGTDSSEEIWEYRGQLLSPSALDLVLRQETLAQADSSGQYAGEVSWDDLRGTWIPIWVKKLKVSDLAEGEIPDSSPAGFQERDTDAWGNKIGWHGQHKEMYYKGEPKWELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS75</accession>
    <name>A0ABR3BS75_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ferrochelatase</fullName>
            <ecNumber evidence="7">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613720.1">
        <property type="nucleotide sequence ID" value="XM_066758318.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990693"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="357" mass="39208" checksum="7D29808293961A88" modified="2025-10-08" version="1">MGGPSTIPEVHDFLSRLFHDNDLIPLPFQSLLAPFIAKRRTPSIEEQYSAIGGGSPILKWTQLQGAAMCSLLDELNPASAPHKSYVAFRYAKTLTEDALAEMKQDGVQRAVAFSQYPQYSSSTTGSSLNELYKQVKQLGWGGNGEVKWSVIDRWPTHPGLIDSFAHNIKAALQTYPEDRRGDVTILFSAHSLPLDIVNRGDPYTAEVAATVWAVMSKLNFSNPWRLTWQSKVGPKAWQGPQTAAAIEGYAKAGTKDICLVPIAFTSDHIETLYELDIEVKEEAEKLGVHLTRASSLNDSPIFIRALADVVSNHLEDYDAGLIGPASKQLLSSDPRHVSLKSQETKRWLASGGTNMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSC3</accession>
    <name>A0ABR3BSC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103162</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614046.1">
        <property type="nucleotide sequence ID" value="XM_066757662.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990018"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="160"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="323"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0249859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="906" mass="101055" checksum="851E6BE8FCF8EF6B" modified="2025-10-08" version="1">MSRSTTPAYQLRRPALNILSASASSTASRAGTPPSSNTSAKQIISLDEWESKSPLSDEQIGSIGAVKARFGERDLPEKFKNEGSSVATPAPGSHLYLPSSSRGPSLPNTPTPDDSSSAAIVPSPLYPKLISTPQQFLDHFTQLTLSTEHEQDSLYRDHLSEIVGLKERCNGLVELLDEGEKEVKEMEKCLGYVEERSESLRGACEDLLEEQTHLLTHTSQLAHRLTFFTFLESATRMLNNPGNDLVLNPQFLPMVKRLEECITYLGEHRDFKDAEVYLLRYQQCMTRSMALIRLYFIGVIKNLGQEVGRRLADQSLSETATQAFIYTKFISLSATLRPLLAELEQRVASNPDELGSLLVECHTTYLTTRRNLIGQRVNAEIGRMDPDKSDLVDLARSGCSYLKQTCTDEFNLFKHFFLSGESQLYGFLESLCDYLYDHLRPRILHEPSLQVLCGVCTVLQALMVREVTDEEDDDESAIFTPSSTPGSLHYPGGDDYFSSRPRMYRSGSSRNISHSRSQSIRRVSSYGSHLSRSASPTALLSPSTLAAMVKSRKRKPLSRLHIEVLLRMVLQDAQTRLVFRAQALLSADVEYYAPKEGDLDYPERLKLGLQGNKLVSRQLAVSLDAEDDDEPAILELPPPDAQKSWYPSLRVTLWVLSCLHTYVDAVVFEDLAQEAVIMCRRSLSSAADMLVAKKGKKRTMDAKMFLVRHLLILKEMTAGLELGKARRQEWSGIGDFLKSLLDNASSLLGYQRGSAQSNFAPDARTDIDRALKAACEDLISLVATRAISPLRSFLDKCTAYIAKSAASSSSAKTDLSAQEFATSEKVKEVHEEFKSICTKEIEDWKKGLRMYLLDEDTVAVLLPPAYNAIVDGYRQFHDLIRAEYDFSTAAGIMRPSGVMDMLEMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSF3</accession>
    <name>A0ABR3BSF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614078.1">
        <property type="nucleotide sequence ID" value="XM_066757694.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990050"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="600" mass="65505" checksum="0D4C1828247BF0E5" modified="2025-10-08" version="1">MAAPKIKPLPPVSVQFLGTSSGGGPIQSRNCSSLAVDFGNEIWLFDAADGTLNRLHQSSLKLANISRIFITHLHVDHVLGLVPVLTTVMTGTMATKEATQKIKELGSKKQPTFHLYGPSGLRNLVRAILNITQANLSGVFAIHELLQDGEESSAGCREDEIHPNEAVGMDMRADEDGVWKVVLQEGNGKNGKGWKVSAGPIHHRVPSLGYVLQEPTPRLPLDTATLIPLLQSNSEALAALDPPVKHPLSLLSHLTSLPPPSPFTLPSGDIISPPEASGILPRKIVIFGDCSGGTKNHIFRSMCEDASLLVHECTNAAIPQAIQREEKGQKARTRDLEPSLMRSQGVSPGQSAPSSGYSSANSPSTPNGLQALKWDKENADEIKRGEVKKKAQSRGHSTPDEVGEFAREIRARRVVVNHFSAMFPSPRYPTAAALPSILSSICSFPYPVPRPLPHTSLPPPLPVPLNSKYPSELHVRVIMQSLADQILDKCASFSLSDEDLGKPPRGKTGMVIPARDFMHLPIPSHELNALEIEDVRSYKELADKVTEEWKKHGGIWIENGEEEWIGVEKEVKVTGWRFKKVAKESDEWVVDRVKEDSNCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSK6</accession>
    <name>A0ABR3BSK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614111.1">
        <property type="nucleotide sequence ID" value="XM_066757727.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990083"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="200"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="375"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0249924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="81638" checksum="8EA13CA6E0955386" modified="2025-10-08" version="1">MFVLKSLLGKMWGNPANPELIQIPAGLLYLVRPDSIKGSHAVATIRRTGTEYQYQLVVTRAYEEGEEQLLDEDAETDDERVFLIDQGLQFRFGTLDGDATCSWKDLSGEEGDRWEFVSSKSVPKATNSLFELTLLHCMFERKYLRSHEEATDEQLQALKDTEEHDIPKAAARPEDITLEAQLSSLGLEDSEDPFQNVPILHRASADLYVFDTETELFVIQESNVSADLAENAEFDTWVIVRQGTTPFISAPVDAELNAHFDMVNHAFMFTFREGDGVPAMTWCLRFKPDCFNEWKDKFTIYMWEGKNKVKYAKAKADEQRYIQEAYEDIEMAEPEEEEVVNEEENEAEDGEGHEDSAHEDEDNDSGDESFAQGSKNQHLAVGYKNDLSYVTRGDMIGVFAHNGDRLKFRTAIDRIKNVQGKAFSPHKMMLHNQDSDMLLLDPSNKGSVYRMDLEYGKVVDEWKVSDVVAVNNIIPDTKYAQMNPQQTLIGHSHNGIFRIDPRVSGNKLVESQFKQYASKNDFSAATTTESGKLVVASNKGDIRLFDQIGKNAKTALPALGDPIIGVDVSADGRWLVATCKNYLLLIDTLIGDGRYKGSLGFDRSFPADSKPIPRRLQLKPEHVAYMEDPVSFTPARFNTGNFRMLKQGRTDAYQIKRYDSRVVADNFKFGADKNIIVALEHNVLVANKKDLAKPTRSSLAPNTLLSTPARKIRQSHSDIVNSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT25</accession>
    <name>A0ABR3BT25_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613978.1">
        <property type="nucleotide sequence ID" value="XM_066757594.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989949"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0249791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="166" mass="17675" checksum="AA0A1CDB6BC6FEF9" modified="2025-10-08" version="1">MNDFSLPAELTSNHSNHWADASSTVPMAYPSPGLVIPLGSQNGCEAAGIRTPCLTVAGKKRPLPPSSNQKGRLSLRTPDCLDQLHQAMGYPPCVKMNPGSRKRLQAGLDTGCAGSIAGVAFARSVFRWRDVFGDVPMDMPGSGSEPGRMYDSPLGFLSHLQHNGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT41</accession>
    <name>A0ABR3BT41_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613993.1">
        <property type="nucleotide sequence ID" value="XM_066757609.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989964"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="774" mass="84818" checksum="B2802FF140D74D59" modified="2025-10-08" version="1">MSEQDTSKGTERPLAAHNPPLPSNSTPFSFACRCLNVKIDGRVSAADEQKVFSEGEESTSAQGRVEVFLPTGSEGVKFADYVVYDQDITSPREDKSGSAIITDESPEPSWRKCFICDTRCYRVKDKAQKDPAAEEEWVIVELDSGIVYGEKLSQALGQEGLPFSGLLFDPPSEQSNFGRPPTNPTPSSDPDSYLPSPTPSAHYVPTPHDPFFLPPPFIPSNPHLKDLCDQAEKYLREAHGRLEDEVRHFISLKTLELRDLEEKVRGEVESLWDKYRNGPGKEEVSLQRSASNSRTRESSGRGSEPSSIFTPLKSTQSQKSFHASPPPSHATPNPIMRASIAPATSALPNGTSLLAQSMSQASLFPQFNEIGTAGDVPEGMRDEIDHTISEVARTYGKEGDSRAVAMSYIFSSFAENMGGATQVSRVNQEEAESPENTQASNKDSWIDQETANARMAGPTDHLDAVVEEDSADGATPRPRQAKQLEEDGKPEEKGKKGKERAKVTFEEPEKPGRHSRSADEDKNPMSTSEDEDYVFDFELEYRPSEPVEAVPFSLPHPSAGSRNMLEANLSRTFAADLPSHRGAWRRIEQNGSMYEALRRERRSDTSDNAADDSELSKFATSVPIAINPIRAGQANVPVALERKTSLTDRPGIFVPGLRPAMREKGVTSNSLGLGFPKGVQSSSARGRPSDQQRKTSRSASVSREREAVESYAADPGPVFETLADGENEEEEEEEDSTAAGKGTIMEKGFVPPHVLARQEDSKKLPDVGWRSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTM3</accession>
    <name>A0ABR3BTM3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zf-C3HC4 type zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614494.1">
        <property type="nucleotide sequence ID" value="XM_066757025.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989337"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24139">
        <property type="entry name" value="SIP5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="558"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="609"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="748" mass="79566" checksum="A9FF57EA88CCFDB7" modified="2025-10-08" version="1">MGNTPSSHATPPSSSSTSNAPTSERERSSSSAQPMNTSTAGRTQRPSVSFHSGLTPPTSPPSPPPPSTPPLLPYGGHLSPQNPHCLSHPQAHDYSKSAVTRLILDGKLAPFYRGLEDFEEDWTEEDIGRILTEMREKDYAEGVANSCTERLKEEREGGSSLGNMTKKMGIHKNKELRREGEKEERERRERRAYLSAVECPICFLNYPPNINTSRCCQQPVCTECFVQIKRSDATITHLESEPACCPFCVETEFGVIYERPPTPMSSLSSTALATSPNDTGTSYYSHAFSAGSDAELAIGPGMNPIQKETIRRKSVSSKAKEVVTIDEIRPDWEHKLNAVKAAAARRASRRIIMRQVGDRLIPIGYTSSRAPGTADFSMSLPPIQNGGGADESGSSPRRLSRRRESNREREIEELMIMEAMRLSLLDHEEHQRRQADDLRENSTTADVVPSIPPSDTANTSTAIQSPGPPPGPSTGAAFAATAPSTSSSTGTPRRLSGQSDKNDKQSGASKLLSKFSNVRARANSATSSKGHGSGDFKNTFGRTRGNSGSTQTPSPSPALVTTQTSASASTSNSAVSSTAPSPIPSISPLTTSHTQPQVKTSVPTHSGGLSPTTSTPAAPITTLASPGASGKNSGEADLLGGPNRPTTRADVPVGLPHLSIDMPTLTPEAPGKRVAAPAITTASTGVVHSEGDLETTFSNYGTAPLPSTLSASSWTPRVGLQRSHSDITEVTEPEAEGNGPRYTHLDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTQ0</accession>
    <name>A0ABR3BTQ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614218.1">
        <property type="nucleotide sequence ID" value="XM_066757834.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990190"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25414" checksum="70670264D563DEB5" modified="2025-10-08" version="1">MATNPDSRPLPDGWVQQFNNEHQAWFYVNTKAPGGPASQWTHPADDQPTYAPPPGNPPSKTSTPFAPADDKSRGASEPYYQSSTPQPSSLQQAPYQPTSQSASPGPQSQQEKKRGIGGFFSKFSGNNKPSGYQQAYGQAYPQQQQYGAYPQQQYGYAQQPMYQQQPMYQQQPMYAQRPQRAGMGAGGAAALGVGGGLLGGMLIGDMISDSQHDAYMDGYQDGEMGDMGGGDFGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTY4</accession>
    <name>A0ABR3BTY4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614599.1">
        <property type="nucleotide sequence ID" value="XM_066757130.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989442"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037548">
        <property type="entry name" value="Bqt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="3">
        <location>
            <begin position="62"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="395" mass="42947" checksum="61426009BA3EEAC0" modified="2025-10-08" version="1">MSHRTADAPPPYPGTTNDAQYDLTPLPHTANRPRLPEHKRNPHLNNLPEDTKIVKFQTIVRENKEIVVGRIKVPTENANGTHHAFILRRYDTNAISLTTMYKVAFPSATEEEEKREMDWVKSSFDTRGTNGGRDSEVVRLAGQWVSRNLAIHIAPAYNLVQLVAALARAVPDPNVAYRKSQRSQAAADELARTKAKQAQAPSTVPAVSNVPVPKPQATIPSMTTEVSSPASKRRRKDSVTEASGSATQTVVEAQPPADTSEADDTRHITIEATTTITSPIGANVNMDAEIEQAKQLVKNLRQEIQLRNETGDSLEDQGVAVADDVRGVKRGKHEDEAVVISGGAGGRDRVVRTNRRIPQTAGGDVGQRFGWGAFVFSIGLGASLTLFSQYASSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU31</accession>
    <name>A0ABR3BU31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613800.1">
        <property type="nucleotide sequence ID" value="XM_066758398.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990773"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="677" mass="74258" checksum="06E727F508CED7CA" modified="2025-10-08" version="1">MPSFMSPPSTAAVLPDLRPPKSPRRFFTFSISSSNPPPLPPLIPSMPYFGKGSDRSSSGVTVVRTPQDAAGGMRQAAGLTSPPSNQAPFPPVPPLPPLSSLSNLSSQARYPQASINTHTHGYGHQPSKSVDSSNLYRPSKLERMGVYRSMSARDDLRSGLDRSTSGLVKTSNAAPVLERQIEREESDRLGPMRATPARPLRESPFLSPGHSNPQSTSTNYVSSPPVSFHSRSKSTARSPRMSTTTSNSTLPSISTVPLSPPSKRPYLILNRSTIKPASRSSSLTTFDTPFHAAFLSCTCKPLPKLSSGEQDGITLINIEFAYSFSDPSRNESVILPLEMLKKGGGKLHNWVMDCLTAQEDEEEKKAEEKEEIREERKLPEMTDGESAEESDWDSDCNLSALLRDEYLKSLIVPSPSPMSHTIPLPPIPSPATNVLDVPPFSNGSKSPVTPKSPKAPGYKRAQIRNQYTQLVCKPRTSITTIEPAVPPLAYAAASPSGLTLPLNIKRKTGRQLSLSYISQGVDASTPAKPKKGIFTEMRIFLTREAGVYHQISHRLISGRWNIWANVGGREVRDRVEAELEWLGMADLLHEMRRPILGLSHSRSQSKDLNLGLGLGFGGQETGRANERLIDGFGIPERPVKSERRAEGVKTLCEKRKSESKWRERAREKSLVLRSGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUI0</accession>
    <name>A0ABR3BUI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_102783</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614787.1">
        <property type="nucleotide sequence ID" value="XM_066757318.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989639"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="734"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="712"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0250600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="854" mass="92796" checksum="857CD7F131DFC3E5" modified="2025-10-08" version="1">MSGHYNLKALIKAIRSCKTLADERSVIQKESAAIRTSFKEEDTFARHNNVAKLLYIHMLGYPAHFGQIECLKLVASPRFSDKRLGYLGIMLLLDENQEVLTLVTNSLKNDMNHSNVYAVGLALCTFANISSEEMSRDLSNEIEKLLGSSNAYIRKKAALCALRIIRRVPDLLDHFTAKAKSLLQDRNHGVLLAGITLVTEMCAINEDVCAEFRRATGLLVKHLKNLVSTGYSAEHDVLGIADPFLQTKILRLLRLLGKGDVASSEAMNDILAQVATNTDSSKNVGNSILYETVLTVLEIEADSGLRVMAINILGKFLTNRDNNIRYVALNTLNKVVSMDTNAVQRHRNTIIDCLRDGDISIRRRALELSYALINESNIRVMTRELLSFLEVADNEFKLGLTTEICLAAERFAPNKRWQIDTVLRVLKIAGNFVRDEILSAFIRLVSHTPELQFYTAQRLYAALSSDLSQESLTLATVWIIGEFSDILLQGGTIDDGDGVKQVSDSDLVDLLENVLNSPYADSLTRQFVMTALAKLSVRISELSTPNQNTLQDRIAVILASFSLSLELEIQQRAVEFGSLFSMREFKMGVLERMPPPEIRATIMGTVSERKPVGSTRTDKDMIADLIGDDSAPNTGGLPVTATGPSTQDLLADIFGTGASDIASPGANATAAPKSAASDIMSLFNTTPAATASPPVAFSSSVGPAGGSLFDLATPSPSTSSAPTPAPASTSAVKPQLQSYIAYDKNSLKITLTPKVSPAQPGVVQILARFTTSGTEEIEGVNLQVAVPKTQQLQMQAMSSQMIAPGSVETQQMRIHVPVGAAIRLRMRISFTRAGQSLTDQQDFAGFPPGLTGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUL1</accession>
    <name>A0ABR3BUL1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102564</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614578.1">
        <property type="nucleotide sequence ID" value="XM_066757109.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989421"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="90" mass="10036" checksum="E5970F0F8C6C1308" modified="2025-10-08" version="1">MNHFPLPIQKILEGQIDPQSQQLVASYTQTTFIVLTALSFVFSYLSGSVLLGVESFAAGFAILLIATVPPWPYLKRHPIKFLPVRKLHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUT3</accession>
    <name>A0ABR3BUT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614877.1">
        <property type="nucleotide sequence ID" value="XM_066757408.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989729"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="7">
        <location>
            <begin position="99"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="455"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="697"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1003"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1058"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1018"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1068"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1100" mass="119050" checksum="DB89FFA5BE179B51" modified="2025-10-08" version="1">MSPVVAPSTALPPSTHLEKLTALANAPSNVEAKSIADGIALELKKAPRTLDALQDARIVDVVLAWAASKSGYERESAVVLVERICRSLGSGIEGVFLPLIPAILNLAMDKGQPVRSAVNSAMTSLIKATAPEGARKVFEVLTKVLEETKGWRTKIAALKAMEGLVKPGAEDYVANELGTVIPVVEHAMHDTKAEVSTAAQKAATTLCGILPNADVLKHVNLLVSAMASPTAVPSTIKGLSSTTFVAEVNGPTLAVMVPLLTRALKERSTDTQRMTCVVIGNLVKLVRDPTVAARYLGPLFGGVQQIATGAAFPEIRAFAQTALDILIGAGASANATPLPPRDVTLAVTEALAVMASHLQIPCFPAHPSIPLSASLPNSPVIAHAVEYQANVVADLVDLRRWDASIWEGKALGSFMKLLQGADEGAKATAEIRKAFMDIDKAKYAPPEEDDGSEGELLCDIQFSLAYGGLLLLNHTNLKLRRGRRYGICAANGAGKSTLMKAIRDGKVEGFPPQEELRTIMVEHALQGEDTSMAILDFIAADPKLTHKTRADMAAMLLSLGFSEEKQQDPVASLSGGWKMKLELAKAMLIGADILLLDEPTNHLDVQTVAWLEEYVCSLHDITCMIVSHDSGFLDNVCTDIIHYESKKLVYYPGNLSKFVEKVPSAKSYYTLAATSIKFTFPPPGNLVGVRSNTRAILKLTNCTFTYPGAPRPSIKNASCSLSLSSRVGIIGPNGAGKSTLIKLLTGETVPQEGSVHKHPALRVGYVAQHAFHHINQHLDKTAVQYIQWRYQDGHDREMMEKATRVLTDEDKEMMERPIEGKNGELRKIEYILGRQKLKKSFQYEVKFKGYDHRYNAWIGRDVLIEKGFQKLITQFDDLESSREGAGMRDTGANAVREVLEAVGLDGDIAQYNEMSGLSGGQKVKVVIAASMFNRPQCLFLDEPTNFLDREALGGLAVAIKEWGGAVCIISHSTEFVTALCPEIWHVDAGILTHQGKVALVEDAFDDPSRPGSRVTSKAGTPRTMPGTPGTATGTPTPAESVATDGTVDDVADGLAKLMEKKKKKKKMTRNELKAQEERRRLRKLNWLTYGGEREPDTDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUT9</accession>
    <name>A0ABR3BUT9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103171</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614055.1">
        <property type="nucleotide sequence ID" value="XM_066757671.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990027"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="123"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0249868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="269" mass="29316" checksum="58BAFE06D641B9A2" modified="2025-10-08" version="1">MSYDQVPSESHQFIQPDEDDLEALSFSHPNPSPTPSGPSSSQQQNQRSYAAGPSNPSGVSGKIGQDGPSSKPRAATSTIGWGGVRVETRYTGESTLDEPVSKTIMRDLNSIYAKLILILYPPKGGHNQLLRDWDLWGPLVICLALAIILSLDAPQDQSMQVFSLVISLITIGSVVVTVNSKLLGGKVSFFQSLCVLGYAIAPILIASIVAFLVHSIIVRIPVTLACWGWSVWASMNFFNGTQLPESRIFLAVYPMCLFFFVLAWMIIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUW1</accession>
    <name>A0ABR3BUW1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein translocase SEC61 complex gamma subunit, archaeal and eukaryotic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102944</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614915.1">
        <property type="nucleotide sequence ID" value="XM_066757446.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989800"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="70" mass="7710" checksum="EA7800548F03E719" modified="2025-10-08" version="1">MSERLTEFAEIPRQFVKEGSLFVNRCTKPSADEYKQLCRAVAIGFGVMGVIGYLVKLIHIPINNILVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUW3</accession>
    <name>A0ABR3BUW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1264-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614929.1">
        <property type="nucleotide sequence ID" value="XM_066757460.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989814"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25034" checksum="2055542E6386D096" modified="2025-10-08" version="1">MPRSADDPIAQAEQSHYHSPIYSAMGAAQMSFRPINQIHQHLCGLHIYAHDTKRACVIYDSDQPNARLIGIEYLIPESVFVTLPADEKKYWHSHKYEVDSGMLVLGTKSLVPNAVSDIAERPAMLELHRTYGKTTHTWQFDVHPDLPLGPPQLMMAYTDDSQVDRQALKERDEALGVSTEAKREVRKGYLKKEDLDRPLAEGADCCWEEGKLGQWEYVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV80</accession>
    <name>A0ABR3BV80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_103306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614190.1">
        <property type="nucleotide sequence ID" value="XM_066757806.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990162"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="9">
        <location>
            <begin position="73"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="507" mass="57804" checksum="B26507ADB6B98571" modified="2025-10-08" version="1">MSNESGTNKSHPSAKAPQKTVLNLGNLPPKPKANELRQHASQFPRTPSRVNPNQPPWPAYRGYHEYSFAHATMGVRLPTILGKAIDDVWKTVNQEYEEDRIVDLVNCIGRMEHLMDDLQGNSKLRPIIDDGAGDIALWNKEIAKYFRGKDFMNAPWLFAEAYKYRRLRECFSLSKYFVEYDVFFRQKCDTFSRSNQAVFELSQRFSEPQSIDANLSEQDQLEKKKLLFLELTQVCLWGNSTDLSLLIDMTEEDIKKLQSTGGDHLAATEKNILGNDLHKLADYVATLKGGRIDFVLDNAGFELYCDMVYADWLIQSGICSQVVFHGKKIPWFVSDVTKKDWDWILNSCVYGHLFDEASEVEMDSLRTLGHRWKQYEKEGKWKYEAHPFWCTGYTFWDLHSEAPDLFQYLSESDLVIFKGDLNHRKLTYDCHAPLDTPFPIAIGPLASEPGAPPVCSLRTIKSDVVVGIPTGVGEKLDEEEPGWKISGKYAVVLLSEGRKGETPVYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVL8</accession>
    <name>A0ABR3BVL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615142.1">
        <property type="nucleotide sequence ID" value="XM_066756365.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988671"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="161"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="581"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="673"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="718"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="736" mass="82517" checksum="351FF1F46FE4DEE0" modified="2025-10-08" version="1">MPPRTKAQSSGLGKALINRKAKEAVAPKESQLYTLDDNNPLASVTHERDLDEFLANAALADQDFTTERTKMRVISAPNMPTPTSNPFLLSAEEEKEVIKKKSDFQGDLTVPRRPPWTRQMTRLELEKQERESFLEWRRELAKLAETSNLLLTPFERNVQLWRQLWRVLERSQLIVQIVDARNPLGFRCQDLENYVKEIGSDENDEEITVPGKGKRRSLLLINKADLLTYEQRSAWADYFEKEGISYAFFSAANAAAVQEQAEKQRLRQLGEYDEPKQSNEESEEESEEEEDDTEEEHLTEDLRETHLDEEDWSSESAGRSGQVSRSEVDEKLAEGQTISLSEVAQDVRARFRERTEEEDVRTRVLTVTELEDLFINAAPDLKDFATSQHANPKLMVGLVGYPNVGKSSTINSLLGAKKVSVSSTPGKTKHFQTLVLSDTITLCDCPGLVFPQFANTQADMVVDGVLPIDQMREYSAPVDLLCRRIPRDILEGTYGIRIDVKDEEEGGTGKVGWEEFLSAYAIARGMTRSSFGMPDTSRAARYVLKDYVNAKLLFAHPPPGIDADDFMSTSRAETIARIEESYENGRKHAPVTHVSKNADTYVQPASTKGKDSLDEETELGQDQTKRERQSTSRQVKSTAASAPARSGREKAAALDSVYFNEGGAQPRLVIKGRNQPGDMQEGGQGFSRATRYPHQRLLGPDGMPMLGARGRDLGGANGKKHFKRKEGKKRSGKGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVS4</accession>
    <name>A0ABR3BVS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101883</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615211.1">
        <property type="nucleotide sequence ID" value="XM_066756434.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988741"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF15">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="510"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="797"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="844"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="806"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="862"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="888" mass="98804" checksum="69B7C707979607BA" modified="2025-10-08" version="1">MSDDNPIRRQDYLNYPIQTGHTVSLVPQSESQEREHHPELQGITRNYLGSDPNSAHIRDQSLDMPEGEGYDMTEIPHQSSMSRLTPTDGTSTPGRVHYPPSPLMPRGQPQGDAYTTIPLQDDHSNMSASGTNTPHSGSTNKKKWSFLPGSRSSAILEKNAVDEKGTKRRPKNQRGTSWDLLGERGEWEEYSPKNASVENLRFAEGDVGTNKLSRLYYWALNKGIVVRWAMYIIPVLILFWIPGIIFYAGVRDAKVWTVTLNWWSIWLTIVWLTFWGSTAAFMMLPHVWRNTVAVIIPSAKPLTDIIAALGRYAKLIIWCLAIWVSFTPLIVNHYTGDQSATSRSDLSTFANLLFGLFLCSIVYCVEKLIIQLIALQFHRDSYEDRLREQKFSLKALTYLYTNSHDIPGRTDTLSDAVSTKTKGSQIPRVALKKALKGLKEAAQTTTTALGNVASEMAGQSVLQTNSPANRVTMALNSANKSKALARRLFYSFRAPGADHLDIQDIAQYFPNLETAQAAFAIFDKDGNGDATRDEIESAVLGIHRERLALEASMRDLDGAVRRLDDIFLVVVVAIAILILASMITNKLTTFVTSAGTFILGLSWLIGTTMQEILLACIFLFVKHPFDVGDRVDIDGVQYTVAKMQLLSSSFKRVDGKYVWIGHNVLTTKVIENIRRSGAISEEFSFEVAFDTSFEALQALRSRMIVFLKENSRDFLPVFDVTVYDMPGQGKLVLKADIRYKSNWQQVSLKIQRRNKWICALKMALADLKIFGPDGAGNPSPEDAGPTQYTLVPWEECKPRTPEDSTAPPPFTSAAPSPPPLMDTRAAIDNPYGDIWNEGEELLAFQSAGPSRPGTPGAGPALRQRQPQVPQPQDVLEMAGTAVDAKRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVW0</accession>
    <name>A0ABR3BVW0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101916</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615244.1">
        <property type="nucleotide sequence ID" value="XM_066756467.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988774"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045085985" description="RING-type domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="302"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="733"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="788" mass="88937" checksum="E8F91FEF753B0CAF" modified="2025-10-08" version="1">MPLLARLGNRASLLLHRLVYAFPAAPPPTHSSTSAPDVSPNFDPAPAPEPAPALSFMGSGYGVTLILMGILLNRIHHTVRRPRQPPPNDHPVAHNPSYFYRLRTSVSTFLTSPDAPRYIRLPGIVGLLRAWILFTVVLIQVLGLWPEFQHDGTNAMWRKAANRLGNWAGEMEMNDICWQVFVSVCVGLLCSGIANGLDTIRRRDVAASFNLTGYSFMMHLYSSPLTHRHTEQAVAHRRPDVHAVFQLWLSLTELTWLQILELSLALRDNVLLPTSVCGIVGVVHFAYVLFSSPLRFPSFTFLTHMLALFLSVVILSTIILRAITFIFSYGYIPSLTSLLPHEGVIPDRRDDFGVTLLKIGTACIEATSFSGLRNELANIDKPREPWVEITSDGSEFHHGRLLQHSPPTPGFSTEISHIKVSEAEDSERLNPQWREVRVFARALLTAILSALVQFLMSTRVGRSMFRFGKKMWRARWWYGPRSWKFWRREAWREPSENIRARERAGERASARARASATIVQQASGPGDAASLQRSEYSRGTSTSVGLRGHGESTTTIQRNPQPRRELWTYADYLLKDVDVEIEDDGEWIQEVSDDSDSDSEQMSIADVNDEEEEDLTDEGMDVEEEEEEVKQRGMLYGDLVTQTTENHGRQSTDDDLQPVLLAHLTSRTAAPLTRQRYTSLMTLYSSDSFHTPTPASLVSVRSEDVVGLRDVMHERRQAMKNYQEEDEETKSTCVVCMVSMRDTILWPCRCLAVCNGCRETLAARLPAQNHMCPCCRKKVEGYSRIYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVW2</accession>
    <name>A0ABR3BVW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomere replication protein EST3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614148.1">
        <property type="nucleotide sequence ID" value="XM_066757764.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990120"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13595">
        <property type="entry name" value="ARL6IP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13595:SF3">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="820" mass="94406" checksum="A41CFF625F3CA0B4" modified="2025-10-08" version="1">MADDIRSWITKALIDHDIKHGPNFRVPVNCKHYCQLLKFYTYRDDKNPRAQIEGSIGDRTHCVKVIFDIEETDKFELPDPDTGYKHSLTSQLRSIFQIKQFQIRIAPPPPSAGSKIPLVAFYVTKWDVVSGNHDEPVYWLDTCKIGEGNNDGKIREVLKKWWFGESNSESSQNRSSQKIPSQDNIPDMSITTAGPRVKNDVTYHRTSVALGDIISIEEAKASRVGEWDPRFALAWLERNQDTVLNTYAQYRNYLSNNIETIDSSQRFQGKTVSNEPSGNGHPPKSQPVDVVSRDSGTPRLFNKRSPSSSSQSHQASSPAFRRVSPSKRQLLRKKIIDPLNFPSSPATSMSPGSTDEELLSQYEREERRRRGESKGIKGDGDKELEQRSPSSSQLSQSSLVFHSSPTMATPRRLEGELSQTDHPSPDLSSAQNATISNTRDKWKRPRESMSSRRQSRVVILDEDEDIDEGPLIKKGSKRKLILSSPEPPSQVIEIRDSSDDEENVAETSSSPTTQGGTRGDAEHTVTALQDLMPRTKEVTRPIKTPSSSSVLNGIGADQRAVEDGDEVEDKGERKRENGLNDEEEIMEEEEGEEEEEEEEEEEEEEEEEEEEEEEEEEEEKEEEEEEEEEEKEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEVEEEGKEEIEKDRKIEEKEEGEKLQTGKKGKGTQDERSTRMDLWGMEKEKEKREPQTSLPVPEGETEHFRRKRKNRTEDRTSSQHVPKFGGFKLDMTLREGGLDEACVLQMLEWAREKRQEIAKRAKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW95</accession>
    <name>A0ABR3BW95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615383.1">
        <property type="nucleotide sequence ID" value="XM_066756606.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988913"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32507" checksum="77242D4EDC5D1DE1" modified="2025-10-08" version="1">MSDGEHALARTVFGSDKLSASKLFNVDGWVVLVTGGGTGLGLITAGALAENGAKVYITGRRLEPLQEAAKIAAPKGGKGTIIPLQADMSKKEDIDKVKETITSKEKWLNALINNHGVAITPPKIDDAEQTAEGLSKFMYDGEKFDNWLDAYRINTASYYFTSFAFLPLLAAAKSVGNFSEPGNIINVASISGMTATSQGGQFSYNSSKGATIALTRMLATELARRELGIRVNMICPGYFPSGMTGYTEDDTKPSKEFKDKMGTPLGRTGNAIDYAQTVFSLLSNQYITGRELVVDGGYLINQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWI4</accession>
    <name>A0ABR3BWI4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL46 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615469.1">
        <property type="nucleotide sequence ID" value="XM_066756692.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988999"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="1">
        <location>
            <begin position="32"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="271" mass="29613" checksum="28664CE0E2B81F4E" modified="2025-10-08" version="1">MSVAARSISRTAVSGSRSAAQIRFSSTAPPPLTASLLLSRPPLLTPTPTPFESAFYSHSRSIAHALSSPLPLDFYFKTGSLPLRRHLVAEHAFVSETYGKKLSGKAPDVGDIPPETEYEIIERDRWEKADAKRGEKSLERKPEEEVYCLVLKGKGKEGKWMFPDVKVGKLEALDEAVARGITGVEGSLGGKGMDSWLVTRKPVGTVKDGESRTFFIRGHILGGEPTLSSSSPYSSWAWLTAPEVEARLRQQGDGKLWDDVKGMFGIPKNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWM2</accession>
    <name>A0ABR3BWM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102177</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615505.1">
        <property type="nucleotide sequence ID" value="XM_066756728.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989035"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="388"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="513"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="717"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="890" mass="97350" checksum="E95617C017F8EAF0" modified="2025-10-08" version="1">MGGDHKCPLCSATFTRPQHVGRHLRSHTGDRPYECKECPLRFARSDLLSRHVNKAHRAPEEGATDKKLTKKGRRKSVPASGQSALARARIQEQDEEQRRQLLQRQQFECQQQQLLQQQMQQEAVAVRERSKSESLNQQPHLQALRMYPHHPLLASRPVQPSIASDSWNTNPSGSFAAAGMTAMSPPFDSTPQRLGGNFQTFQGQPFLVGQLPNDPPFTGQPMRLSGSDQGMKTADGHSASVLYEWGVKKRACDQCNHSKVRCDFADPCLRCRQRNLSCSYRKPPKPSFTMGPPPAHCSLPLKTGSTTMSPKSPYASPNSSTSVIAPTEPISYRKPSVTSLPPNLGNVPNPSNAQSMPWVSYQTTMGTSWPSSQAQATYSIPDGTAPGSITGQFVDSPGAVNTALPSYSSQSQAQAEQSLSPHRLSMTQTPSLADSIDTSSEMEMDDPAERRGSTNSFISSVPRAQWGSKNKEVEGVLRLIPNTDAFEQNQSPIQTTSHQVSPVLGRGCQLSDRISNPQWQSQGTINPKWQMRGSFSSDDESSSVLSSSANSTFLEQSVNSSANHEDSHHERRRSSGSTWDKAMEQMSIQDPQKNKPIVGENEDRSVPTVPEILETASEGTQELHDLVGTNTEQSSMVPTLSDVKDLWRIFMTEPATGLTPAGEKLNELDNIPVVTPRPGMGKRTFSKSTSMPDLQSPLVAGPAFFSTFLSGMTPKPTEAQQSYMPSHLAEKDRPSVTEDLDEPDMGKWSKEIEQRQSSFSLGRPNAKLGKGKADTLSRISDVPNQPLATHPTRPLASVFQRSSALDQTLAPERLPSFGLTPGFEIQNPFLSKLGLASADARAGSKRMASSTLANDHKKATFTVWDEEGPATQVMGQVTAQRARRLQAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWX4</accession>
    <name>A0ABR3BWX4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615602.1">
        <property type="nucleotide sequence ID" value="XM_066756825.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989132"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="11788" checksum="B78C72375AD7AB6B" modified="2025-10-08" version="1">MSSKPISALSGISVAGGIMAYTRYSSIPSLIASLGIGSAMMISGRRIRDGMDYGYESAAASSAVLMYPTIRRFIKTRAPIPATIALLATASTAYYLVETFDGRAQKPVATTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWZ5</accession>
    <name>A0ABR3BWZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615537.1">
        <property type="nucleotide sequence ID" value="XM_066756760.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989067"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="813"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="850" mass="92951" checksum="F23BA259F0B00845" modified="2025-10-08" version="1">MSSTNAEASSSRRPPQLSLRSSAASEPSPIKSEPTSGTFGDNSSRVQSDRGSVRRTTRPRVAGSNRKIRTVPPSAILDPPTPPSPVRAPLEPAIPVSATDSARHRRYPAYYSDSDSDEEYSTDEETPWWTFTQRGMAKLRQMNLRHEEVKGPTEGESAKEDKESKKRGSYFISSRHNSKEGTPQFSSRRRSNLSSSRGNTSPTKNHTPSTKLSNAQFFRRQSKDVDPLERPSVGAHGLPLSRTDSAPARTSAPASPTDRGSPGGITPANDQNTRPSLHESPTSLIRGLPDDAPGSSTRITRRQLTAPNFPRLFRARDGMNSADDSTDTDVPASARKRRPRSSLPTFSIPESSSPQAQTNDNNMPTNDNGTSPDASPTPPKYKRKASHLLRINLPPPITQHFASNFSNGWPHAGSWQDALYGYYEDEPSNVEKERGSRGDAEPLDPHESPGMAPAPPLSSPHEGDVESSGEMPALSTAETKRSKSKRHAKRFQALAPPTPSGLGFSPRASIAGMDEYPWGQTAQGEGGESQSRQPADAEKDLRFRQDPQRLSQSDRVSKELRTNGDQPQPLSRPDTRATTINTNTESGGAGQSTPRGSGWRLFGWHHEDKRKDLNLSWKERMKRVLFLDARVTIYIRLFNLAVVVVALALSINIRLSLIYLHLPGVLGSSTTLIICYSSTTILHVLTAIYREYFGRPIGLWGLRSKMLWVCLDLLFVALWSSAMSLAINDLIVTPLECTAGSAWWNNGLADGYAHLLHDLHSSITSNHSDSNIIPFVGVTGVVGVPTTLSVTLPTSVVANSTVRAVCRHQEACISLSLLALLLYGGNMVLSLFRIFETVRRTANVSRAVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX61</accession>
    <name>A0ABR3BX61_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone acetyltransferase type B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615690.1">
        <property type="nucleotide sequence ID" value="XM_066756913.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989221"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="45827" checksum="340B9D092B51F49C" modified="2025-10-08" version="1">MDTPGAGPSRQSSSNPVANNKLDPNVKPGTVLLTSDLLSSFQPAKRFKDAVLDPTSTPSGPKTHSVTTLTFDDTGDRFISAGDDNQFILWDARRGKKIKSFYSKKYGIDHVRSTHKTGTILHASTQGGDHAVRYHSTHDNAYLAYFKGHTARVRSIDMSPADDSFVTAGDDGTVRLWDLRANACKGLVNDVGGSAIAAMDNTGVVFAVACSDTQTIMMYATKTADVHPFIHQGLVDIALEDISTPPPKPIFTSLHFSNNGQYLLVGTSSDVHYVLDAIYLTPLRRLVGHSGLERDAQGNKGVEPRRGISGEELCWTADSNWVISGSANGEVVAWDLRPEPGQSQLTRADVAGGNWHSANPPDWTTLRIPDLKPTVVLHGDGAGSGPTRAVKFNPRYNLMAVGGHDLTLWMPIKDEEARLAAEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXV5</accession>
    <name>A0ABR3BXV5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615086.1">
        <property type="nucleotide sequence ID" value="XM_066756309.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988613"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="478" mass="52172" checksum="CEB8842D9BDA8851" modified="2025-10-08" version="1">MFEEDFERCFICQGPSKGLYCSSMCRQKDQGSFSPQVNPDHGSVHITSQLPLALSPHVRPTNTTSLSPKSSGQPWPTSIGTSSGSSSANSSPLHSPQTNHADFDSPQKGFFNLPPPAYPVTQFGAPPPSAVPVKIPALLPRASPIFGAIGTPGSQGSTVYPHGASVDTLRFGRRPGAVNSVTSPNALLPRCACGLPANHHRIRASSKDRADLVDSGFSRLSLGPSVVAREEPISRSLRIVSDSAIPPFTLSPKGTAQIITATLNHSGPFHTEQSSPVAPNNLLSRSRSDPIPPSPKVGKRTIAPVPVVSTIVPTRRQSSHEPEYRTNILEISNIDSPRRGRSRERQEHHEDDSDCPPTILNHPPEREAAPSRSRTRRESRRRSGERSRSRPRERFRELDMSRDREQGGQRSPVSHDFPQILPSWSQQATIVDHVVAPSMKRQSSGDKKYARDKGDESKREELRRAANQFSQVFGVKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYW5</accession>
    <name>A0ABR3BYW5_9TREE</name>
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        <recommendedName>
            <fullName evidence="9">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615808.1">
        <property type="nucleotide sequence ID" value="XM_066755522.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987819"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF23">
        <property type="entry name" value="DUF726-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0253587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="73542" checksum="A594D3529F4FB2EC" modified="2025-10-08" version="1">MTGTDLPKPPDPLAPPIRLIVALASLCAIVHPSHPINPAAREWYKENSTSWLQSVCKLLSFDIAKLPPSIEPESVKASAGDQRREWSEQEEIRISGVLVEASIAGEGDENGKSGNGKKDEALKYSPLARAFTYHTLELLGLPAKELVPQAEKNLSHTLFRALLAASEKDQQEKMESTRAAHSQGWGGALGRHLATGAGVVAGGVLLGVTGGLAAPAIAAVLAPLGIGTVLSASAAPVVLGTLFGVGGGGLAGRRVRERWKGVEEFSFIEVGDDHKPTQEEIDDLKVSHKNVNQKAAEKERKEQVTEKAGIEGEQKEEGDGSISKEQAAKNVEAGRLDLEQKLLNLTSQSGVDTNPPSSTDSQPASLENAKEEKELAEAKRPPSLTATIVAPGLLTVSRTEAITTWRAICSSKTNSQVTLAPRVVARRKETETEAKAAEHKDDSVRPLGLKDGRDVYLLRFESATMLQTGRDVDFWVESQLKGLVKKEIIKRTLLNAYFAAVSLPLSVYSMATMTLDNTWMHVQDRAKKAGRLLGEVIEKRVQGERPVVLIGSSVGALTIQHALLYLASLPPPSNSKLSVPAYVESAYLISLPAAPSTEEWDKCRSVVSRRLVNAWSDADLVLAGVVRLHEVVSRAAVMSNGIRVAGLGPVEHLGVENVDVSSVLKGHMELQAKMPEILKIIDIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ39</accession>
    <name>A0ABR3BZ39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615879.1">
        <property type="nucleotide sequence ID" value="XM_066755593.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987891"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="421"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="528"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="638"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="744"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="848"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="949"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="1153"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="1257"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1443"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1443"/>
            <end position="1456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1481" mass="155165" checksum="097348CF34DDE7DD" modified="2025-10-08" version="1">MASAQIPDDPLMFDPLLSSPSGPHWFATTGLSDDIYKRWARRRFSSYLYCFTIIYYRRHAPQDDAWHLDDVYTLANEELDPVVSPNRQSSHMHKIIGGSRMAAYYNFDDYAAAKCSSLRIQADKSNYWMPNIYVISNSTNSTIMYTPVSAKSRFYYFLSRSTPNEAVIPFPKGLRMLTGNPNNKAPTNVATFTCQVNADLSNTIESDNFNFDRDCPYGMKTELYFPPCWDGKNLYKSDGSHMAYPSQSVRSGRCPWTHPVRLPHIQLEYTWNVVNVGPGLPMKGRLAWANGDTTGYGIHGDFVNGWDLDVLKKAMNDSTCVGINKSIPMQDCLTLSGYFDDAAAAACTPELGSLVEPYGNVDNVAVPVLPGCNPLWGASGPKPTCNPPVAGLDISKFKGTDGPYIAEDDERRDFVLPTTPGWKNIACLHDISSISGGVSYTDSSMTINSCQSHCLTAGYQYAATGQQGTAWNCACGTAISDTATVETGMCLTPCPGNSSQLCGGSYIFNVFYAPPGTNNSNPTLRADGSTYIGCYNNPSNSSTGLLGASTYSFQSNSMTTETCISACVQKGTDWALTTSQRWCYCGNDWNYGSGAFVPSSQCTVSCTGNSSEICGDYYKSSVYNITSVTASNTTIPHLAGYQGCYQDTGSHLGMTNNSWTSTTMTQSQCINGCSELGYSYAGIFGGNQCYCGKPNSNLVTLPASQCQSSCAGSSNTTCGGSAAMDLYTVTAATVTSGTIASQKPSGYVGCFKDSSSNAAFTSAVYTYISSSMTPDLCKQVCLEFNYTYAGLENANECHCGKNYPASQQMVSSLYCTASCPGGSSQTCGAAGYLEGYSLANTTSTISKPDGWLGCYTDNSNSRTLQAYSYTANGMTSTVCRATCGNKGFTLSGVEYGTQCYCGNFLSGGTRAPASSCNMACSGNSSQTCGAAGYLDLFNTTGVSAVSNGISGYIGCYTDYSVLDGASYSSDWLSVDSCNQWCYARGATYGSVRNGNTCKCSSKAPSALTTTASCNNPCSGNSTQQCGTSGAAAVYQIASTNIKSGDFVISSNSSGYVGCYKEGSSRMLPSYSFTSTSMTNNLCITNCKSLGYAFAGTENGNECYCSAKLNATSGGYRAQDSDCSTTCKGGGGNCGAGGALSVWSTANAIVSSTTEGLKGCYATGSFISSASLSYLGDYMTTDLCRRTCRAGGYSVAGLTNANTCGCSNSTNYGAEQAPTTCNAACNGNSSQTCGATYSSAVSVFDTTGAGAQTPPGYPNYYIGCISDGNPRILPDFTYKNSAMTSELCRQQAVANGYSLYGTEYSTECYAAKNRPNVPLLPDSYCSSTCGGSSTEKCGNGGRLSYYAIQGGVSAAQVSNAAASLGASSSVAASSTSQVSRAASSSATASSSTSKAASTTSAAVLSTSGASSSSAAASTSRTSTSSSSSSSAAAAASTSPASSAAVSTSSSASVTRRSLPSTESNVRDLSRVVHQPRGWYIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ86</accession>
    <name>A0ABR3BZ86_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615928.1">
        <property type="nucleotide sequence ID" value="XM_066755642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987941"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="251" mass="27877" checksum="A392EB0C55495A09" modified="2025-10-08" version="1">MNIPKGGESSNSNLWQSTPNRLVFEEFESYPFNNDPEFRAGLPTVISAIRGKKLQPSSIDEMLSRAQWFYFTRKKNIDLPWESYARHSQMYQWPPNTNSSGNALAQLDTLAEARRMLTAKGETGQQGMSFEMLVRLVKEGKADQVEITPVPDELHEGTPSQPIMDRRPKPWERSFTSTSIHFGEPGSMMPPPPPVVSSDTGIPTPSTLKPITSSIHANGSSAASTEGLYNYYGQMSEEDMALIFGDVKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ92</accession>
    <name>A0ABR3BZ92_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615927.1">
        <property type="nucleotide sequence ID" value="XM_066755641.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987940"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="819"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="933" mass="103037" checksum="67816A55E821F937" modified="2025-10-08" version="1">MDHRGSRGRSRKHQAPCCCWQQGEKSVRDITGGKGPQNTLKRDLYARSLAIKDGDSVSAMSKTFMFPQSPSLPVKEMTIAELADFEAENGESELHRQRMLACERRIRYQALIGETVEGEKTTKFSYNSSFQPHRTPQYRISSPSPAHNPSSPVPSLPLPPLPKTSFALNDFIPRSFSSSPGVPASRGDTGMRTSESDHRYNQPNNPGLLNLGQSLYVRTLRRESSIEALRRELAIASLTLRVSKRNSNSSMLSNLSTSCDSYSCSESDTQMGEAVLQDPSLAFQPQALPYPKVKPALSRLSIDSASSESMSIVLGNDTCSDMKPLTATGLQALSCDSSPNKSPECYSATRLGIWPSKSYPSPLEAKRKVRLRSSLAMPVRWPERTEEEEVPTKVSEAVRNQPTLNGCMWEETSPSPKSRPRIISPEPQIMGEEEGAPHSNQPTPQVEEKGRARSDSSLSAIAAFPLPPIRTEAPQIKSAVTSIAKEKEMSQILQEKEENTAVLFGENICPSPSLVASLLSVDQRENVKAGKGVRLDDSPKMDTNFSDLTVSERRPSSPELHALINNMRKTRKKRNGANGQTEEETDESDLDLSTPLTKLAVNMKIVAADPQRLHDRSSACSFSPGSSHNTSSLSDMGHPMRTGGVVLKNERLTTSDYGWSGSESEEDAWNEAMEKRKPQKRRPSPNRNIRPRSAGWNTTPSVKSTVHTDKEATPKSSQALFYNTPVPIPSFTPRTPNAEVKRLSEVSSSSRATTNINSTEGSITSLSLFSCEHNVPMSYAFSSTSTASSTLDDFPWDASSSPNSPIRKTHASDSRVTPRRSSISPSSTASNKETLVKNRKAAALRSLPRPLRDIEGWGEPEILFDDITWEAEPSPNFKSTFYDEYKPVFIQVESQSSPSLTPSKLQKFRTLVENKEDARRRLISKFQHADSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ95</accession>
    <name>A0ABR3BZ95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615934.1">
        <property type="nucleotide sequence ID" value="XM_066755648.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987947"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF8">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MyTH4" evidence="3">
        <location>
            <begin position="106"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="298"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="52973" checksum="AE7EFAF47E83A766" modified="2025-10-08" version="1">MGRSISVETLGQDGRKQRPPKKPRQTMLAVSTGALRKDVPLEPIFVEQPGSVKTKRLSAGRHSRLPPDISSQIRAFQTDDISQKYFAIRRAGMFRTKVPVSRIMEWQRQSTTAPLLVLSKRLPKDAVTCFKVIQHVMGEGDRPVESAKPSHTGPSALPELLFKGKRNEDDAPKRVAAAGDGLADGSGPRGEKMIMLEEIRWMVQLSDSVVLGFQLFCVFVNSFGPSKHFETFVKNFLEKHLNGQTDGIGIMAKYCMTKIETFSAMGRRAKRLTVGEIEHASDAAFYPSVYGESLVRIMDLQKTLYPQLKIPVILTFLADGILALGGTRSEGIFRIPGDGDGIDDPHVAASLFKLWLRELEEPLIPTALYNDALIASKDYAQVVEIVQKLPVYNRRVLVFVVGFVQIFMQEKVVEKTKMGPMNLALVLAPSILRTTADSLVTVFTNSSCESKFMQQLLENMKPGEIDPDYVPVHGVAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZQ8</accession>
    <name>A0ABR3BZQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAUS augmin-like complex subunit 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616086.1">
        <property type="nucleotide sequence ID" value="XM_066755800.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988101"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="75460" checksum="866B74F14EEF5752" modified="2025-10-08" version="1">MSNSSDSVCRRINGPPSNGTEAQQRALRLAAFKYIQDDIPEQVAAYYLRDHHLQKTLSVISQAPVSIPSFSERVRRLNFMDSESVIQTLGYKRGEPKLTNYRNWDTSRVSQYSKTLQEEAELLCRGREYVQHILEGSGTDRLQVLLQDMNTHLEETKKHKNRTWSDATCTHLDLIRRSYNLAQSHLTVNQMLPDLATKMYNDLCSLHSGASKPLTGKNKTRSRPWTDALSELRFAVSNLQSSAWDIDPDLLNEIEQKTDGFFRETTERQEEPIRQGHMDALTKRDLDDPTYGPPPQRFRLTRLNELESYMEAKHAEVTQMMANVDRDWKDVSDGANFKWSEVTTPAISRQTADSWFGMSSDAPFTQSHVTDGCSHQDHLLECTIPSIPSKVDYAPDLSALKPIPQVAFNCLSALQQDIDSYAETLLSKQPRSKMVPSQKAKFHTAISSAMEEIVERSRTKWEEMTAQLNDSTVAPDGLDDVLMSRAASNYFTLRALLTRHNEQPTTNKKESRAWATSVQKDREEAKKWEKNVEEWHASRRTSESIDVSNDDKTSQQLDKVATQIEAATVSDTPTIAPQLTELEKLFIANGLEPREHFDWFEEVQEHLPLPNPTATTSKTSSRTEGTSASAISKPSRGNSLPKPNEGMKCTDTWLMKTGRKTESKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZR5</accession>
    <name>A0ABR3BZR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615842.1">
        <property type="nucleotide sequence ID" value="XM_066755556.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987854"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="62338" checksum="FD58B067D4985862" modified="2025-10-08" version="1">MKVAVIGSGLAGLTTAYLLRQHGFEVWLIERSSSLGFYSESIEMDQASTKTARGKSRERKWIIDVPMRGFQGGYYPKLLSLYTHLGLPVVPVKYTFSFSSSQSTYFIHSGASGASMPSLPSEAFTDPSRLARALMKLFGIALCYLLLIALSFAAWHDFLPPSLSSTTLTVREFTINLSSFLSRPIRIPVIGLYPWTPLGNVFEDFMGTIVLPLFSAVGTMTAADVWAMPVRLLLEYVHTTLGTSHYHLGDGFSSADVARLLAAPVKDQGPDYVRLKEEVVGLEYALGGGVRIKLRPAEDLKTTAEETLRVEKVVLATQASVSGQLLRNLDKSLKHWGEEKERRRIGKMVQGLQTVKYRETIVVNHTDASILPPLADRRDINLYLPLEPCSLPEIHSSPSSPYFKPTSDSIYAMATQIIYPKSCDGQPVLQTTNPVISIGSKRVLRVSKLERALAISNPHETLPLLQPHSLNALIYLAGSYVYPGIPLLEGCVGSAKDVVKSILEGERYHIETKLGESPDMWDKKKRGRKIEPVGGIDWEVGRGGLIMRAWRWRWNTERTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZV1</accession>
    <name>A0ABR3BZV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616136.1">
        <property type="nucleotide sequence ID" value="XM_066755850.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988151"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="46"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="223"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0253915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="437" mass="49053" checksum="4B8C8287C0905410" modified="2025-10-08" version="1">MSSNFYTSSHNRYWLLTRPSLLQSRQTDLKYCTSRQLYCLFIFFSQLIQKLGKRLLLRQIPIATACVFFKRFYFKNSLCETNPYLVLAACVYVAAKVEETPVHIKSVVSEAKLVFHEHNIKMFPAETNKLGEMEFYLLEDLDFHLVVFHPYRALLHFTGRESADMGKFEKSRVQEDTEIRKKEGDAKRLREEEAKKASSKGQQPTVGQALEKEGGRLEETEEARIRRLMSRGTGEGVMEVDEGVLQISWFILNDSYRTDAPLLYPPYIIALSAIYIAFCLTSMSNSSARTRASSTQRPELLQSASINEGLNLLPPPKNAAEFLAGFQVSVPMLFSCVQEIIGLYPVWEAFEPTVMRNSQAQAKTGNAVAAAAGTKSGQNDSVQDKKDKFGLEEAESLVRKMIEERMIDLGHPDNAGVEKAAGTGSSNAAGKKRARIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C010</accession>
    <name>A0ABR3C010_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616191.1">
        <property type="nucleotide sequence ID" value="XM_066755905.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988207"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="578"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="423"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="852"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="953"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="497"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="694"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="857"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="884"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="909"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="953"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="991"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1168" mass="125483" checksum="9A53C05D0177A695" modified="2025-10-08" version="1">MAPQPAPSRQNGVPQQPIPRPPVPQQGIPAHFPVPNQAPTQYPIMTYPPQSGFYPGYNPYEQQQNFGMPPQWAPQHHPQNQFPGGYNARPVSPPSGTAPFQPAQQPFIPNSGFPGGSGPNAPQTPLRSSGPVLNGHQHTSSNASQTSAPSTPNFSLSSASASFTPRRSAAIKISRPDGTEFDLKKEALKVSSATASPAPTSPASTPHTPATPSSELKNAKVDTPKKPVFGLPVTVKIERPEERAARLEEEAKKERIRAQEEKEEKERKERLEKKAKEEEEKKAKDVAEKVEPANSAGEFIKVENGSVEEVVSGAPSSVPSPAPGAGLPPKPVSVVNSTNAVPAALNLAAASPSLVSEPSSASISALSSARPIEDIHAISYPGSLKSPNPQLNASAEPRKFRYDREFLMQFMNICKEKPESLPPLEEIGLEADGGSGFGSRGPRGGRSSQGPSSRTGSTGLGIGGVSRATMGSFGMGQFGSGSGSLRNSTSEQRYRASLSGRSSSQGGPGGLPSLSGLPSMGLSSSRGGESRGSQRGSKRVPQSSQPSTPIAAPIPISENAWTRKRMGGDAEGTPAYIERKVKALLNKLTEEMFDPISKQILEWANKSANETDGLTLKLVIKLIFEKATDEAHWSSMYAKLCRLLHDEISNDVSDTIDGQVISGRSLFRRYLLGRCQVDFEAGWKAREDTAVAAAAKKDEDEAKQEKAKAEDSGEDKEADLMSDEYYAAQKAKRRGLGLIQLIGELFKREIVANRVISQCLLKLLSNVNDPDEEDIESACKLLTTVGAAYDRAARENLNKAFDVLNQMMKIESLPSRIKFMIMDLNDLRKDGWKSRKNQSGVMTIAEIHEQNAKEKNAAAAAARESLSRGGSRSGNRRDGAQPGEWQSVSSNPRSISRPTDFSNIGRNISSSSVTPSFGPSSVFANRKGKAAAASGTPSPISRPSSANMFSALHDAHESESPTERRTSVDEGEAAPQRKKLNLAPRTKPLAAEDDGREEGEEAQSEEEAAGTALSEGDIKSKIDLDMKELWGDKDQGGSRNPSDVAEYFSSLPESCRPLLATRLLDDLFRISKLKDAEVVAKGWKVSLEQQAVSSEVLKQALEARMPTLDDEAIDFPNAYDAIVLLTRSLSLSDDDVSALGDKIEVDGTPRVTPKQKLEKALAKLNEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0G7</accession>
    <name>A0ABR3C0G7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616338.1">
        <property type="nucleotide sequence ID" value="XM_066756052.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988354"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0254117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45819" checksum="D9C7F2FF3DE9BD1D" modified="2025-10-08" version="1">MVAVLASKVFDVIFHPLFPLFFSIPLFLIFFLIYTSVAPYFATERQRAYILSTMSSWFMTLASLPFAWKYARHGLGTIYEDGQNGWMGASGRVTVVFFATYLFSDVSFAQVSTLFNSTKARHVGLLTGWIHHAVYIGLMSYLLNTRHSPVFLTGAIMELPTFDLAMSKLYPSVRHDLRFLASFFIFRIAFHAYLLGDCLRSSSRTVTDGSWVPSIILALAGALHVLWFKGGVTGYLRRLGRSKAKADSAEEPLGGILDQNSVTTGRLALESLDDSPGTPDDSPLMTPRTPSQTPFIFPAIPSITIPSFSTLSNLPIVSIPTIPSISGLSLAEIRATLNKEGKFKLKGTGFKEAVKGRWEGHRESFVERTGLSFGALKMRRRREGQIKEYIDEQADEGQLMTMSVGNHIGQSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0N0</accession>
    <name>A0ABR3C0N0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_101578</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616419.1">
        <property type="nucleotide sequence ID" value="XM_066756133.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988436"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046773752" description="Glucosidase II subunit alpha" evidence="11">
        <location>
            <begin position="25"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="13">
        <location>
            <begin position="91"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="12">
        <location>
            <begin position="375"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="14">
        <location>
            <begin position="711"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0254198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="957" mass="107909" checksum="6A288CEE96D8C7E8" modified="2025-10-08" version="1">MMIRLPLLWLTILATLVLLPLTLAVKSEDFKQCSQTSFCRRLKSIATKQQAAPKGTFNSPYSLGEAVPIQGGGSWKWPLKSSLYPQINFELDVDVLKEGNGIARVRIDEVGSSTPFKRYDETAKWALLNAEPEADPSASLKTTKGKSVITYGPSSSITLEIIHCPLKITQLRNGKPEIVFNDRSLFHMEHFRVKDVESAEGILGEGEQAVLGGDAHDRSWFEESDSDAFQEKWKKWVDTKPKGPEGFALDISFPGVQHVYGLPEHAAPLSLPDTVGPNAYYSDPYRLFNVDIFEYLADSPMSLYGAIPLLHAHSKTHSVGVLNLVGSETWVDVLHTSSDVKTHWISESGILDLLLLPGPSPTDLFKQYAILTGPTPLPPQWSTAYHQCRWNYNDQDDVLEVDAKFDEADMPLDVTWLDIEYAEEHRYFDWDKKHFPNPPAMLDAVASKGRKMVAIIDPHIKRTDSFRIYSDSKDLDILIKKSDGSNFEGWCWTGSSAWVDFFNPESWDWWTKMFDFKVWKDSTNALFIWNDMNEPSVFDGPEISMPRDNIHAGGWEHRDVHNINGMLFHNQTAQALIKRENPPQRPFVLSRSFFAGSQRYGAIWTGDNLGDWEHLAGETAMLLSNNIAGMSFCGADVGGFFGNPSHELLVRWYQAGAFMPFFRAHAHIDTKRREPYLFEEPIRGYIKDALRLRYALLPVWYNAFKEASVWGLPVIRPQYAVFPGDEKGFKVDDQYYIGGEGLLFKPVVQEGAVTTEVYISDDQPYYDYFTHRLYPSSPQTTLTLHTPLSTFPLLLRGGHVIPIRPRPRRSSPLMWQDPFTLIIAVGKDGKAKGQMYLDDGVGYAYESGEFVWRVFELDGKMLRSKPHPEVIQSKETGVAVYVQGNAFAEAISHVKINSIVFLGLSSKPASIKSNGVELEFEWEEGKNAKGKKEGKASELKVKNPGVGVVEDWEIVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0U0</accession>
    <name>A0ABR3C0U0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616466.1">
        <property type="nucleotide sequence ID" value="XM_066756180.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988484"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="175" mass="19733" checksum="A9E54F1A02BF1AE5" modified="2025-10-08" version="1">MSSRPHTFLRLPRILPAPHRQPIARSLHTSIPQTRPNTATTSHGRIGSTSGYASGSGSGPSQSGSGKKPNRHADWYREIVPAMIPIFVISTTIFLSLSLLRTYLSHSKSLAESEAHIALLETQLAQLRLEQKKMRIREKRERERMLPLVVERVLQRVGVVGEDEEEKEEEQPRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0W5</accession>
    <name>A0ABR3C0W5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616482.1">
        <property type="nucleotide sequence ID" value="XM_066756196.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988500"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="772"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="160"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0254261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="901" mass="99682" checksum="F319A84B4BFF2D7D" modified="2025-10-08" version="1">MAFAGVGALGPSYDRTEHSAGATLNRTTSRSHYYNDHPNDNLPSPTDEYRNRELGQLARSWTRRSQTGALGRGTSQAPQDESIAEEVTGDIFTYEKESDLDPFSSNFDAKKWTKLMFRAYETTVPSRKAGLSFKDLGVFGYGSDADYQKTVGNLPLAGLGALRDLIGNRKRKVQILNGIDGVLEAGEMLVVLGPPGSGCTTMLKTIAGEMNGIYIDESSKLNYRGITPKEMYGQFRGEAIYTAEVDVHFPNLTVGQTLSFAAEARAPRHIPNGISKKDYAKHLRDVVMSVFGISHTLNTIVGNDFVRGVSGGERKRVTIAEAALAGAPLQCWDNSTRGLDSANAIEFCKNLRLNADYMDVSSVVAIYQAPQSAYDLFDKVSVLYEGEQIFFGKCTEAKQFFIDMGFHCPSQQTVPDFLTSLTSASERTPREGFEGKVPTTPQEFAAAWKKSDMYAQLQEQIAQFEQKYPIHGENYDKFLESRRAQQSKHLRPKSPYTLSYGGQVRLCLRRGFQRLKADPSLTLTQLFGNFIMALIVGSVFYNLPVNTSSFYSRGALLFFAILMSAFGSALEILILYAQRGIVEKHSRYAFYHPSAEAIASALSDIPYKVLNCICFNLALYFMTNLRREPGPYFFFMLISFCLTMVMSMFFRSIASLSRSLTQALAPAAIMILALVIYTGFAINVQNMRGWARWINYLDPIAYGFESLMINEFHGREYACSMFVPAGPGYEGATGEEHVCSTVGAVAGSSVVNGDAYINASYQYYHAHKWRNFGILIGFFLFLTAVYLLATELITAKKSKGEILVFPRGKIPRTLLAQSTASHNSNDPEAGKFAGGDDVQKKVTGANRADAGIIQKQTAIFSWKDVVYDIKIKKEQRRILDHVDGWVKPGTLTALMGVSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C178</accession>
    <name>A0ABR3C178_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616141.1">
        <property type="nucleotide sequence ID" value="XM_066755855.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988156"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31535" checksum="7C817B084431C8E8" modified="2025-10-08" version="1">MEEQQQPSMRPSKRPRLQQSYSVSSSASTSASLSAQPPTLNKGKGHIVDGQRLQEDPPEEDRTTEESANDSEDEVEKDNLIEIYSPRSSSTGKRAWATRAARRAERLSEAEKCIHIPSMPPPSNPNSDLLQAIHHHASHFYTSTSLLIPPKKRQRAMPWASKKRINVLKDSLRSKGHKQDIESLVNEHGEFVAAAREGKVDGGGIGGPRGRYKVRDMYCAIEGEALMAIGIILQEYIIRTLREIGYQPGEATQAEIESEDDDEAQDGSEEETYEEEEISGPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C182</accession>
    <name>A0ABR3C182_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101544</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616385.1">
        <property type="nucleotide sequence ID" value="XM_066756099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988402"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0254164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="604" mass="65806" checksum="3B745909E98097A5" modified="2025-10-08" version="1">MFSARKYTPLPTSANGPSRKRTAAGLTAWKRWALLATIAVALIFLVFGRSGGGSDEQIYNEENTYTPSLDEDVVEGDSIDYSSPPFRPEDSNVAQPLDHEDGDDDVLHALPVGDTSNPHDPTSNEAQDASEAEGDFTEVTDEESSSEEQSPYPGSFEEDPDPTSTTACTEPISSDKPLVQYALTIDAGSTGSRIHVYKFNNCGPSPQLEYETFMAVNPGLSAYARDPTAAAASLDPLLEEAYRVVPESLRKCTPVEVKATAGLRLLGQQESVAILDEVRNRLETNWDFTVNGDRAVEIMDGKDEGVYAWITANYLLNKIGEGADSDDTLAVMDLGGASTQIVFEPKFPADSDQALVEGEHKYELTFGGKDFTLYQHSYLGYGLMRARRSVHNLVAFTWSFGQGEVEWENLSEDIEVPNPCLSKGMTRRVALDPPGRPTVNVTMNGGNGNFEACNRVVELVMAKDAICEVKPCSFNGVYQPSLLDTFPRGQLLALSYFTDRIKPLRPSSSTLSISELTSMAKDVCAGPDAWADRWGSDPVAMEELAGRPEYCLDLTFMNALLGLGYELSPERELMVEKKLRGVELGWALGAGLALVEKAELTCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1I7</accession>
    <name>A0ABR3C1I7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101586</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616427.1">
        <property type="nucleotide sequence ID" value="XM_066756141.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988444"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="823"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="964"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="841"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0254206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1001" mass="108258" checksum="A742EA0B27D74369" modified="2025-10-08" version="1">MDYYTGDPRPPRFSYPPQPPSPQSHNQRYSPEKRSAYDNSDYHRRSEYDDHSSKASQKRPAEAESSSSQQAAARGHPKARTESPSSSTKPNMKKEAGGSDQQAPRRAAQACLRCRKQKLKCIGGWPCNRCTKSKNVCDFGRPGMGPPAREGGTSEANARLEQLESSVANLLAGLAGSSSNNYPNSEVLHTFDPAQRRAQSISEQGNPPYAPSASGQWNSSIPPPTHIRPLEPPRVGAAAVAIGAPLASASPDDLAAQHHVRFTSSPHQTFIQHGYSPSNFSSNGTGPSPGSGIGSYDSNGFRSERKKVGGKRQKAEERLATATDQDFDEAPFKPLVYQPSVWDNREASRRNSPQPSQSTASRDEPGPGYYARRFMRDRDDPVNTEIVEPRMAETLFNFFIDRCHPFLPVVNVALDDAFNTIRQSPFLTSAILAVAARFYIRYTSRNPDSFPLLDPAVPPRLANLAEAHLANTLLRKQHALSDVQAVMLLAAWGLQSGGRGPDAWVVTGHAARIARRLGVHKILAQAAEAARITRPETEEWSKLEAFMPQWRTWLCWFCFDGFLSLGFGRPQSTQFETVDEQGFLQIRLNQTPPRPGTTPSMSLYGDVYIAGQVQLTQIGRDLINWGEMLADPKGATWADPRRAQIFHGKELSVKMMFKELNGRLDEWCKLWIWNVGSPYSLYLGSSARIARLQADHMRLCLNSFALKSSPDEDEFVAECLKKALNAAMTTIQTHYESSQTDLALSFATDYLTITLAQAAIFLVRIAQAESSVQAILKIEPSVIAHYLKMSVDLLQTGELSETRLSTYLAKTIRDIARAAGINGLGPRESAEDSGWESRPQSAQGSGASATGVAASGSGQATGASGDGADNAPPPDLAFDMDAFLQFESQLDLGYLLGLPGDSGAFPATTGAGQDGQNLNGVDNGAGAQGVQGVLDAAGEVFNEFGFGMAGMAMGYGGLPSLPPPAPTTASVSGGSQQQHLASGGGWNMNGRAMSQEQETGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1S7</accession>
    <name>A0ABR3C1S7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615937.1">
        <property type="nucleotide sequence ID" value="XM_066755651.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987950"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="897" mass="100002" checksum="9DC2B598064620B7" modified="2025-10-08" version="1">MLGPRIARKVARIRHARLACRNLHTLDTYPPPSHSLLDKSTTQPSPERQFPLYKPQQYAREIPLTADTLAALPSEQALSRQLKRRVTQKATESLPEFTEDELRDFYAALVKSGSKDAGGTYPALGAPSETKKIPMAEKEREEILTGMARRLVGGGGLALPEGSTRYSKSLELVANESLSSDAPYAILGILSQAAILSGPSETSKGKAVEGQLPLRSLEVPLGMVTSKEWNALFQEFIRKGDAASAESLLDIMDAHGVPVDLERINSVIHAYALKGRSEDVARLTLDVTAMGETVSSDQQDNYILSILRQTPSNPGPAIARLRQAEIAGTPFPQSSYQAVISHLTSPSSIVQPNSHTRAVAWDLFAHMRLAAHPTPTRELYTTMIKSCGEANQPEPERARDLWIEMTEQEKIEPSTEAYNAIIKSLGSTKKDYLEAFDLLRQMLVKHNDAVFVPFEEDDGIPRFSEYVPTLETFASVLEGTKRAGDVNRARWVLSEVIKLSRAGQALNVPNWKEGPSGDLMASVFMTYAAWNPVLRKKEVKMRKSSSEGASEKVIIEKEEHRLPKGEEFLNVDVLQDVVESSADSSSIDYTFEEPPVNDYLTPLSSADAIRECTSLFHRILSDIQSSSSTSEFLPFRHVYITRKLINSYISVYNAHGPSLSSVKQVYDTVWEEASRASGLSVKPNGWTFIPLLEKCASGSRGGIYPADRSLALSWGRTLWSSYLLFSKSASLKLASIPSSEHLTIQRRKYLLGLGDRQTERIWKAVIKLEALHGDTDQALKLLEEFHTTYRPDAITQSYAPLPEMGLRLKMFTPAMTPEADVPPLLLFDDIKPLHQRLVREARAKDIKKVKWIVAGYEQSLKTRRGWRMKGVGQMREKSKVKDLERLLAQQSEMERLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C2V4</accession>
    <name>A0ABR3C2V4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616312.1">
        <property type="nucleotide sequence ID" value="XM_066756026.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988328"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="296" mass="32286" checksum="05405D33D35CA5D5" modified="2025-10-08" version="1">MSPIVALIGHNGTVGENILPYLVDAHKKGAIKLVILHRPNSDVSKIPSDAGIEKRIIELEEGKIDAIKAVVKDLEVVISTIAAANTPNQVYLAEALVGSPVFKTFIPSDFGCVWSEEEISSPGLSFLKIKEEAAENIKHLKVPITEIKVGMFDLFFFGYKAGGTDVKGNQVQHYHKSLNTQIPITSLSYLGYSVSQLVSDPSLLAKLPNSTPYIFDYAPTGQEIVDVLTQLHGQPTKTVEVSEENMAERLKGSWAVGAAVIKKWGDNNWGKVPKTEISGWTGKSFAETVKEWVNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3R3</accession>
    <name>A0ABR3C3R3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616549.1">
        <property type="nucleotide sequence ID" value="XM_066754648.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986927"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="753"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="933" mass="100749" checksum="1A9C4780F1B982BC" modified="2025-10-08" version="1">MSPRPTRKSLRPIAPFPTAQPILIPATVNTANSSTQHDVQLGTGITRHRNRNEDKDGDGDGDGDGGWNGEQQRSSLVPDSLVVQDVDEGTGGNSPRSTSGSTSRSGVVVKRQVTVQVLPLSKSTVRTGERRSARVRGKEEEREKRPDSERQERLDWPVEHVNVDGQQAVGQGSDGTVEQEVEKLVDLPSGGTEVTSTKHKPAPKSGQPSAAIPQSTVFGVSESKPRAQVSSSTTITATAAAATTKAAPLRNSMPKTKPPIQTKRIPSTPNASPSLASTSTPTTASTSTDSKYKGKLIERRVLPARIRRAAGGGLEGMRDVEEMVVDWLQRWGEPVTIPPDRLPILLTTLPLEMLNPPPVFVPTSSSTSSWQEQSSGGPPITLTPSRRIDPASTEMVTLKMEGTGKDALVDVTGENMLGKDEMIETPGWVMVAPWEDDEQEAREELENGPFLGSGTGTATGTGGIGKGKGIVSPVKRLRRMHDEPEEDTSDAHYIQLHRKHEAFERRQRLREKEKLQFERYKLRSRIDLLRNLSKPAWASIVATILARDEDGWKSGRSKVAKEGEEWLRERLLKEGEEVMKRYEELLPPENRKHKAGAGVNAHHHPLLTTDGTPNSSTRFASPSGSTSASRVPSLTPEPTVLPARVAALRDPVVGSTGKRKRSSMATSTNAGTCKAHPSLSALGDRNTVEDENEKLDGVEEKKGDASGRRKVAKTDTDRKERSQNARLGVDETEAVGDGDGDGDGAEQSLNRGSLLDPTTSSLLPPQISQPQVSAPPPLPLPPPFFPPLTASGLPCLIEAASRRESALKEAEASKARAAEPRKGRLINREKTRMSKRLGVVNPFGLPIPGVVEYKYEFTLTEEEDFWPIIAEREAAANMHRRASLMGQGGLSGLSGSGPIGASSSGSVHNEESVRQMGQTAMLGTEKMENIVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3S2</accession>
    <name>A0ABR3C3S2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositolphosphotransferase Aur1/Ipt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616559.1">
        <property type="nucleotide sequence ID" value="XM_066754658.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986937"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF7">
        <property type="entry name" value="PA-PHOSPHATASE RELATED-FAMILY PROTEIN DDB_G0268928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="6">
        <location>
            <begin position="128"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="369" mass="42979" checksum="15A3A85873290ADF" modified="2025-10-08" version="1">MSKPDEIPALSYIFEPAFVVSLLTAGCLFNRRPPPLIVQAQAAINEYVPPPGDSSWNWKEMVFLKWPVRVPGNERFRGTWTSRLLGMFPFLMEVWYWLLTYWIYQVARAIQALTMGADFRVLAEKHAREIIAIERWLHIDCELSLQKSVMKTDWLLIFFNKTYAMVHIPATIAFMAYSYRYFKPYIFQSTRRTLVLCNCLAFIVFSSWPCMPPRLMPYEEFGYIDTLHTGKAASIWTTNKFQNQLAAFPSLHFGYSFVIGLSLFLYSPHRPIRAISLLYPLLILLVIMATANHYLLDAVGGFFVTVLAYRMNRPVLNLRPLEEWFFWLIRTERPMDKVVFDSVISRENVSHRDSSDISHRALIFQGNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C405</accession>
    <name>A0ABR3C405_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616636.1">
        <property type="nucleotide sequence ID" value="XM_066754735.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987020"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF5">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="179"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="662"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="715"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="903"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1055"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="747"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="789"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="916"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="944"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="956"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1091" mass="120520" checksum="4434D4FB3E34751E" modified="2025-10-08" version="1">MPDLLTPQALATAGPLLLDTLFKHYLSPRQRSDDDKNKAREDLMYDEAFVLMKTFLEMATKHPVSALQRFGQVRTLSPPWVAVHRVQVPFPSLQSAAEYIVTAFGGEEMTFKIAGGTKWWQVRAGQGVEAEWIVMKKDWKEVVEEEKRENEKKNGKKKEAEGEREDDEFLPEMDRLRCMLYIHGGAYYWGSINTHRYTIWRHARKMHGRCFAVNYRKAPQYPFPCAIQDCLAAYLYLVKPPPGAPHRPVDPKSIVLAGDSAGGGLCLALLQILRDTPGLELPAGAALLSPWSDLTHSFPSILQNTATDIVPPYSFIHKPSSLWPPPPPTLTHAVQSRLRSRVKEAAARIREHDQEAKSKKGHSEGIKGDKLYTVVSRISTRSHGKVNQRHSNPEGDSGVESSNVVHASTPSEAKTSDSPTSSPSTLHPTASSPTDPNAHPAPREGPPNPSFANPASLFRTLVPPSPDETRPTTLAQCTTPLSLKVKDEKVVLDTQIQIYATNAQLCHPWVSPVLGYLGGLPPLYIMCGDKEVLRDEIIYLAHKAANPSDHPLRPDVVALFPSLEGIESRYGPTNVHLQVYDGVCHDLPLFSMTTAARGCFRAIASFARYVTPSTPGSLYIGRNPSVAEESDVSTPATPNIFMTPIDSVDAEQRDKILGAPMASSPVQATPHSSQVSLRPNGVTSPPLRRKEPLSSEIPSLPELRIQNLDRSLEGTAGLERASGKINEMEEQEKKEVGILPPRRGTSLRESFTPSGSGLQNTSMTPITSATGGEVLGDDTGPRFAFGTGDQKRENGEKGVELEKRKEEAKEGEEGYSGLNDSRAKKGEAGWPGIYRGDNPFTDHMIRERVSNIGVTRPLTPPPQLQALTMPPEEIGKIKEGPAMRYINGQTLWDKKYRRTAERVKKRREKNLLQAHKAGEKAGRRLEGVVRESMRAEKAKKRKERIKEKVKGKKMDEEDEDESETESSVEDGPTTVGTSMTWTWALKGEAPPPSAIVSRRDFSEARQLALMADRIDSSVSHATPLHGLNIWVGLAGFFSTSAEKEKTKAVLKQVKEEKGNKAKSVEDDPGEIGESKKSRGKVWKMFHWGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C416</accession>
    <name>A0ABR3C416_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616649.1">
        <property type="nucleotide sequence ID" value="XM_066754748.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987034"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16992">
        <property type="entry name" value="ENTH_Ent3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="28"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="495" mass="52736" checksum="EE14F55B5DCF7F80" modified="2025-10-08" version="1">MDLIENLAKQASQLTMYDVKSYYTQAKNAVLNISEMEAKVREATNDDPWGASSTLMQQIAEGTHNFAQFNEIMPTIYSRFMEKEAREWRQIYKALTLLEFLVKNGSERVVDDARAHISTIKMLRSFHYIDEKGKDQGINVRNRASEIALLLGDVEKIRTERRKARANRNKYQGAGNDGGMSFITSTGSRYGGFGSDSVGSGSSAGRYGGGDDFRSSSRGFRDTSSSQSQFDEYEGADDFDDQPPRRTTSISRSVAQAPPKPVAKEKEVEKPKEVNLFDFDDEPVATPAAAPAVTASAAPAVGGDDDFDDFQSAEPASAPAPQAPAPAPAGRPANANVFDLLNSTTSAPTSAPSISTPAFSPPASNSSGPTFGYGAMPPPFNVVPSIPSSNAAKPPAPSSRPSYTSSSTPSALSPRPTGGSSNSTFDDLFASSLSSIGKSNTTQSKNQGGKTIKDLEKEKMVNSLWGSTASAPSQSTQAARPAQPKASGNFDDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C433</accession>
    <name>A0ABR3C433_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616664.1">
        <property type="nucleotide sequence ID" value="XM_066754763.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987049"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="455" mass="49431" checksum="60C20CF49F62472C" modified="2025-10-08" version="1">MTYTEKTNVVIVGAGIFGMSTALWMLETGKYSITILDKSDVLPAPDAASTDINKIIRAGDYKDPLISRLAVDAVSHWRKPEWEGTYHECGVVALSAAHEKEGMDFVNSAYKNCRDLGLDATLLPDATAIKPVVDRDNCFTTGSFGNRQGYINPIGGWGESGRAVEVGLRRAKKLGAVVRAGAEVTGLIKEGKDIKGVELKSGEKVFGDLVVIAAGAWTPKLFASPSVAARLPPIVATGQSVAILQLTPEEAKKYAKVPVVFNLDDGWYIFPPNPTGLMKMAIHCAGYVNPVDEVNGVSVPRTKLTPGAEDGAIPKVMLQALRKGLSEVYPELAKKDYVMTRLCWYCDTVTGDWLIDYHPDYNNLFLATGGSGHAFKFASNIGREIVKLIERDPSSEFKVRFAFSPPKEMVEPASEKGDVSAERTQVTDTGADVRCGMRKHLVIDDLIKPEDLKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C445</accession>
    <name>A0ABR3C445_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616678.1">
        <property type="nucleotide sequence ID" value="XM_066754777.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987063"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="551" mass="61161" checksum="A16B9CC94A348FD8" modified="2025-10-08" version="1">MSHLSPTPFVPSKSLIPSSPSRITLHRNQLRHASSSGNITVGGLPNWRRKPKPSTSQSQHSVKSVGSKGSGFEVENAGKRGLGMGMQATPARKRRLTNKSSIGAMSTPKTMNSRFYSAEDDLTSSTCRSISSNELLDSAEDATSPSISANDIDLIGDSRDSIRLVDEAPLRSTILYSSESHTLFPVAVDILVPLNDISSTSQRCWNMIPTSEDAFSNSECHITVPLNDVFSTPRATRIASSLQTASKIGQRQCTPYRLGGSSGLDVISDNTTSEKNNEVLDESVEFMRSKCPSPAELDCYVSDSDRHWKSDIAAFIIGTQLFKAPIRMPVVEDIFLDPELEEFGGQEVATRALTPIPKSTRPLSTRFLKSKRWKMADTLKLPVEHPERSWMDPFGFWWMCHVVSDKSPAAYDPSSPPRPEAPRSSTPLIFPSMASRTTLLESTDYPSHGSVSEEKEEEALIPGKWRGAKMMARMERNFVTAEGEGSRTPESEHEDINGHQEQSERHNGRCLKRVAKSIQSTEEHIRQREARMQNYKDLDDHYSLKVEFVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C473</accession>
    <name>A0ABR3C473_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616551.1">
        <property type="nucleotide sequence ID" value="XM_066754650.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986929"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045752261" evidence="2">
        <location>
            <begin position="17"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="170" mass="18359" checksum="CAACEADC3CD7416B" modified="2025-10-08" version="1">MALVVASLIFAITLSALPSTEPPDEEECKQHFKYLLKKQGEKKKLSSMNDDMGDRAPRETGMGKGEVVAGKPHRFTDVFAAYSFDPPHNQSTYTHGHASSHSFSPPFLPESSSSDSVSTFAATYVEVYKYRGSGLRRVSSVPSLSLSAICSPEGSVLGSPKLGIFVICSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4C2</accession>
    <name>A0ABR3C4C2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616734.1">
        <property type="nucleotide sequence ID" value="XM_066754833.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987119"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="681" mass="75365" checksum="EFA14162CED443A9" modified="2025-10-08" version="1">MVIPQNALDRSRASSSELSELSSEENKAPKTPKATGKKRARSGEDKTAGQTKPKAKKVKANGESGEATKKAKAGTTKSASNSNKPTKKSVKGGKGAIQAETDPLDATALAVSTILHEDSDLSDIESDIERTKQQASLKVAPKKKGTKVTKGPKEKNGKKANGKAKNQTKAAGKIKDKAPKGASKDAQGGKEKLPKKTKDTKSKDAQKPKPRAKKSEVIPEPPIFEKVVTRLGHEEAEQRMALREFLWRFRLILSIPERSLPALDDFDRPITESNVRLISGALLDMIKDELEASKDEDDEDLKETLFNFREELRYYADLPRFVSIFQSLSEPLGLKLPQSPVDRRAEANEAALRSLFDLGDDQPAPAWATELSVPSRRGASRMPQPSEVVRMLLALVERTLTTPKIKNNMEVFALETQVRKEHANLLKKEQTAWENQKQKLQDERLLCKTAAETKANVSQTTRESREHNLRLAQYNTNMRAGISQTSLRFEPLGTDLDGRIYYALSHRPIENDMKPPIGWGTGILIWGPAVAGKVAEDDNLPHSIERWSHFGKSKDVKPLIKWLEWRYKKAVESAEPNGTATVTLDDASSNETVAQHISQLASHVRSQKQVRHEKDDDASSASSGLTPPPTSSREEMMILMNPPNYAPSAETLEDRGKSLASRLGEVAEWLEVLEWKGLGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4I4</accession>
    <name>A0ABR3C4I4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616815.1">
        <property type="nucleotide sequence ID" value="XM_066754914.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987200"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF10">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE (NADP+)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="94"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="561" mass="60243" checksum="68FEC7028DBD60AC" modified="2025-10-08" version="1">MPIRSPVSLSLNRSSRLTTATRLLHTSTPTLIAAASLSKKLQLCNLQLTPHLLAPNGSRTMSNWPKVTSENPLGLDDPTLFIQKGLIDGQYVGTKSGKTFEVNDPASGKTIGTCPEMTVEDTRHAIEVAEKAFATFRNTSPVQRSNWLSELYRLYQASIKDISRLIVWENGKSWNDAMAEATYAGSFFSWFAAEALRTYGEVIPCSVPGTRNFSIKQPIGVVALLCPWNFPAAMIARKMGPALAVGCTSVIKTPSETPFTTLAIIELARRAGIPDGVLNVITTDANLQDVGKELCTNPAVHKVSFTGSTRVGKILASQCSSTLKKMSLELGGNAPLIVFEDADIPTAVAGTIASKFRGSGQTCVCANRIYVHDAIYDEFAKKLAEKVAEFKVGPGFGEGVTHGPLIHARQADKVEEHVQDAVKKGAKVLVGGKRGNGTEYIPTVLTDVNDECLIATEETFGPVAALFRFSSEEEVVARANAAEVGLAGYFFSRDSDRIWRVAEALETGMVGANTGMISQAVIPFGGIKESGYGKEGGRQGTDEYTITKFVAVGTSLHNMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C514</accession>
    <name>A0ABR3C514_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HAD hydrolase, family IIID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616990.1">
        <property type="nucleotide sequence ID" value="XM_066755089.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987378"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011943">
        <property type="entry name" value="HAD-SF_hydro_IIID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02245">
        <property type="entry name" value="HAD_IIID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="5">
        <location>
            <begin position="256"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="448" mass="50101" checksum="EB0AF6ED2C8F1DF9" modified="2025-10-08" version="1">MSQDDGPRRPPSCSESHFHSDAAPTGNNHLSDTQQHKALENHGVVDGETSVEGQQAQSNENDDTSTTTTSSPIQQQVDHQGEGEGERGDDMADSDDVNMEDDGSLEVSTVPLAEEVDEEWWDLKMQWGGKVYDIRVGGNDMVYDFRERIASLTSIPPDAQKLIGLSSTVKGKLNASHDAMRFAHLGVKNGGKFVLVGTKVEERFVDPIKALREGEGAGEDEFDVDYKGKGPGNDPRNKRKIQEIIDKVPITVMNAPREGKKLLVLDLDYTIVDTKPLLSGALPSSECARPGLHDFLKLVYPHYDVVIWSQTSWRWLETKLVELDLISDSRDYKISFVIDRSCMFPVFSQRNGQLYKHEVKPLAYLWASFPQWSAKNTIHVDDLSRNFALNPGEGLKIRAFNKAGSPDGQRDRELIKLGTYLMGIAASEKDFTMVNHKYWSGRGRRGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C569</accession>
    <name>A0ABR3C569_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100112</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616592.1">
        <property type="nucleotide sequence ID" value="XM_066754691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986970"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF107">
        <property type="entry name" value="CHOLINE_CARNITINE ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="8">
        <location>
            <begin position="67"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="754" mass="83630" checksum="6086C089D39E5005" modified="2025-10-08" version="1">MVIRSSIHRIQSVHTPRRALRATSLFRASTHPGSIATGNVSRRMFAASAYRSDQPKTFENQSKLPRLPVPDLEASLEGYLKSLGPVLEEKYDKASLSNEVEKRRLYVKDFASAGGLGRTLQERLKDLDHVSPNNWLNDTLWLALAYHTWRAPLLVNSNWWLCFAEDPLNPPPPSLASSTKESESKVTITQTAVIKAPNPSPLTDVPAGSQGGGKEWLVSGTIDPPVQYEKVVKKEWITPWQVRRAAWIARRFAEFRTKLEREEIKPDEIKGVKFCMNQYANMFNLSRIPLPNCDAFSTPSPLSTHLSLLVDDYYYAIDIFSSSSSSADGVPEPLPAGEIEKRFQAAANDAKQRKERGERAVEIGVLSADDRDNWTKNREHILLLSPSNRSTLTSLSTSLLALSLDPYTLPSVPPPSGDPLRLSAVDAQVRNCATGLEGGRNRWFDKAVSVLVETNGRAGIMGEHSPVDALIPSIVVEYVLDKPVDESQFKSSAPLASGEGWKKLDWAVDETILREIEQVKEKNQKLIDDSDASQLWWGEYASEWIKKTAKQAPDAYIQQALQLAWFLDQGYPTATYETASTRTMLHGRTDVIRSLTSESRAFVKAMVNPESTAEERYNLLSSACQAHNALTKRSSSGNGYDRHLMGLKVQLRAGETHPLFEDEAYAKSQEWKLSTSGLSAGGKFTATGFGAAWPDGYGINYMAGPHLIKFGIESKFSCEKTSTQRFKHNIVQVLRDMRAVCEAVGGVGASRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C596</accession>
    <name>A0ABR3C596_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type phospholipid transporter</fullName>
            <ecNumber evidence="3">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">I308_100594</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IND107</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617064.1">
        <property type="nucleotide sequence ID" value="XM_066755163.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987452"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="679"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1259"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1291"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1338"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1379"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1404"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1443"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="246"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="18">
        <location>
            <begin position="473"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="1224"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="156"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="362"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1494"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1558"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1758"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="791"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1494"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1504"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1585"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1769"/>
            <end position="1786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAL0255787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1824" mass="202887" checksum="ADEAF3DF578D3C2C" modified="2025-10-08" version="1">MGGAPLGQTSFFGQSSIHYAIKLPRSARGEQKKRDGTASLPGATTASTIINSFIKSQQSLPSIMTPSTLQSHGYLSRSSTSTAHLSTRISSHSSFGHQGTDDENLDFFDPMSIDPDLRLRTVKTAHSVLAESIRSEALAEKREKRRRLFRSMKRKASGIGKGTLKRKWPAGDNGKPDSVETEGFNKDAISTTGSLPSQPPPISSSEHHSEKTNGKAKNRKAEFPRRTVYVNIPLPSSLRNSQGEPVVRYVRNKVRTSKYSLITFIPKNLLEQFRRVANIYFLFLVILQLFSIFGAPNAQIGMLPLLAILGMTAIKDAFEDWRRAKLDNEVNNSATTKLGAWKNVNQPKDPRNFLEKVFGLGPNPNKTSKGVQKLRDREANEGNQMVLESRRAEEQDPLEDLAAGDKESYPLGPMRQVDFSTSLAMDSTSDSLAPEGYGQSFSAAISRSSLPSMMSRKSVGVMDWSRSAPGAAQWERTLWKKLEVGDLVLLRDNEQVPADIIVLSTSDSDALCFVETKNLDGETNLKIRHSLKATSVITSEEDLEHARFVVDSEPPHANLYSYNGVLKYNPTDQFGKQMEEKQEAITINELLLRGCTLRNTKWVIGMVIFTGSDTKIMLNGGETPSKRSKIEKETSNNVMMNFVVLLLLCLITAILHGWYRSLSGTSADWYEPGAEASDNIYVDSVIIFFSCLLIFQNIVPISLYITVEIVKTIQAYFIFQDVEMYYEPYNTPCVPKTWNISDDLGQIEYVFSDKTGTLTQNIMEFKKCSIHGVPFGEGMTEAMMGARKRDGDDISAAMENQEEELQALKEKMLKLMTGAMDNRYLRQDKLTLIAPDLVQRLVAPSDPLRSSIIDFFRALAVCHSVLADTPDPSKPFELEYKAESPDEAALVAAARDIGFPFVSKNSHSLGIEVLGKPERWIPLRMLEFSSSRKRMSVVARDPNGKIVLFCKGADSVIYNRLDVNHDQELKDATLRDLETFANGGLRTLCIAYRDLSEEEFNDWSIKYDTASAATVDREGEIEKACDLVEHSLTILGATALEDKLQEGVPDAIATLHRAGIKLWILTGDKLQTAIEIGYSCNLLTNDMEVMIISADSEDGARQQIEAGLNKIASVVGPPPTTPGGKIMTAGMNPAAEFAVVIDGESLRYALQPALKSLFLSLGTQCAAVICCRVSPSQKALTVRLVKEGCNAMTLAIGDGANDVAMIQEANIGAGLYGLEGSQAAMSADYAFGQFRFLTRLLLVHGRWSYVRVADMHANFFYKNVIFTVSMFWFFIFSSFDATYLFEYTLLLMYNLFFTSLPVGFLGAFDQDVNAIAAMVFPQLYKRGIAGLEYTRTRFWLYMFDGLYQSAVIFFIPYFAYGTGESWSSQGRDTNSLWDIGTTVACAGVLSANGYVSINIRYWTIMTWIVNVVSTLLIYIYIPIYSAVTALPYAGEVGVIYPTFSFWAIILLATVIAIGPRWLVRSFKQSYFPQDKDIIREAWVNGQLKRELGIKSRKQRKRQKQEKAEAAKCEETEQGPENMPGSELGTGKDIVQQFQKVHMEGDAFRGLYEPTVTHSPRKEAIRSSLISEEGSPRGMRSYPAASTNYSTNNISSSRQIQTTAPPPLTIRTSFSYAGQQSSLGQSIASDDHDFQSPLRAFDSYPSPSSIHQVEAEINREVSRLKRTSMDIQRASLYDKEEEPMRMSRAPLFSPKGLEALPRGGDSRGSISNLSEKQSISVMGGSAPAAWKGSSPLSNVDELGRENFSPLRRTFEVDVEHSESLGNRVESQNRRPFDDHSPYTEERSSCIPQTREAFDFTDDSSNEWGKKVSKKDNEWECAGYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5F6</accession>
    <name>A0ABR3C5F6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617131.1">
        <property type="nucleotide sequence ID" value="XM_066755230.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987521"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099">
        <property type="entry name" value="RAD201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099:SF2">
        <property type="entry name" value="SI:CH211-113E8.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="56594" checksum="1FBF5E0CD2C335B8" modified="2025-10-08" version="1">MASAQVCRNYLNGTAQNNQPALKLPFQFTEDTIRSDLTIELPQWIFSVYGAAKYEPNLIYEGELSPEELRWRSVLALKEGKVQEYIKEEETLVSNAKAKIASLVADLSATNKLAQKLHQMRFTNGQQPGAPRPKDFSESAVVPSTQIFGPSGMASETRPGSTPFGARSNASAFGGGNGSSFGSGGSAFGAVNRVNPFSTVPAGGGASSGSAFGQSAFGAGKPHAFGSSAFGGASQTGSAFGSPAVSGDGAFGQAAFGQKSAGAPAFGTSTFGLPNPSAKSAFGSSAFGQSAKPSVTSSFGSSAPSSAFSQDNKPVKSAFGSSQAPLAFASTSQTTATPMPGTAFGQSAFGNPSGTTAVNPAATSVFGQSAFGQESKQNPFGMQPQEAVASGFGFGLNQPSAPAAGGFGAFTNTAPTPANPFGQSSAPANPFVKSASATQPTSLNSFAAPATSAFGSTSAFGAAYPSKSTFGFVNTSDSRPAANGFSALNSALKQPQLSVPVPPGWSYDDPWTWLLYGNAETDDSGTLEDEFLDAFKHATFDLGNIPSMPPPLDLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5I7</accession>
    <name>A0ABR3C5I7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617169.1">
        <property type="nucleotide sequence ID" value="XM_066755268.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987561"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22385">
        <property type="entry name" value="KH-I_KHDC4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047890">
        <property type="entry name" value="KHDC4_KH-I_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="180"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="397" mass="41475" checksum="489251E590CE4184" modified="2025-10-08" version="1">MDAERRSRWADAPSTSSPAPPTGSSAANDTASDAAARAAAIAAKIAASLRPGVQGTELVKKEKEEGDFVKDVEINDLRNRYVLTKGSTQKQIEEETGASITTKGVWVPDRSKMPPGEVPLYLHVVATSQSILDAAIGKINDLINQELGPLIDERTLVARNRALGLPPPSGAVPNGRVKWPEQRLYIGLESLRNFNVRAKTVGPGGMFVKYIQAETGARVQIKGQGSGFMESDTGRESDEPMHINIAAPTEDQVERAKVLAEDLLEVLRGEHAKARDAHSQSAQGGVYGGYAAYGGQAAGQDPYAAYYAQTGAAATSTPGSQPGATPAAGGATPAQGSDAWAQYAAYWAAYGYDVNDPQFQAWQAQQYGQQAGQPADAAAAGASATPQAGSATPAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5Q8</accession>
    <name>A0ABR3C5Q8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617233.1">
        <property type="nucleotide sequence ID" value="XM_066755332.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987625"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="315" mass="35364" checksum="CEFD359D4A6E341B" modified="2025-10-08" version="1">MSQRIHLNPNVPRQSPMMGGIGGGYAPDPISRPAETQRFSDNEMLANIQKWSSKVEDAIETYTQPIRPYVPALARFLIVVTFLEDALRILTQWGDQLWYLQKHRHFPWGISHVFLLINVLAMLAGSFGVISKRYPEYSVFCLLGVVASQGLGYGLLFDLSFFLRNLSVVGGLLMVLSDSLQKNKKLFAGLPSLSETDRRKYFQLAGRILLVFLFIGFVFQGNWSLARVIVSIVGLGACVMVAVGFKAKWSASFLVALLSIFNVFINNWWSVHSAHPQRDFLKYDFFQTLSIVGGLLLLVNIGPGGFSMDEKKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5Z4</accession>
    <name>A0ABR3C5Z4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617302.1">
        <property type="nucleotide sequence ID" value="XM_066755401.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987695"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0256025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="47186" checksum="348E9A6066470C0B" modified="2025-10-08" version="1">MVSSHNLFKKTLIAIKPSRSAAPIPTTCIGIPTSPPIFPQEIFEQIISHLIDSPSTLRAIALTCRTLSPLALNPLWYQIPVGLQSKSPLKTHYFGPTTREIISFGLLKPPPFPNLSAELRGMTRVMDFYFRHFGWALALYRREHRFLELFNKVKVIRIHLDSLCGYMSSTGVPSKFEDEDAGYENYAPRLPASEKIVFIGPCYDPYYERWFCSWKGHERLLTKAPKKLVLVLKTNANPIAFRPGSFEASVLLSTSIRDLRDIVIIFHQGAKRSKRLHTIEVSPWRQVRKEMVLLLAALRKKYPRTRITLVNTGCFRAKWLGYNKPVEEEAIQQKVMEGLKKVGMAKGIKLFGRFSDHPHSHSSRTNPEVKSLVEDGRITGGNEKERLMSLSEYLKEEDWEGELDEREIGSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C7E3</accession>
    <name>A0ABR3C7E3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_100218</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616691.1">
        <property type="nucleotide sequence ID" value="XM_066754790.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987076"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0255414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="447" mass="50279" checksum="B259F4D91830C632" modified="2025-10-08" version="1">MSGQNPSSPALGQGKGLVSHGVDLVRALFFDRRYFWHTAFLLFLGEAALSLLVIWKIPYTKIDWPAYMQQVDMFLAGERDYSKIEGETGPLVYPALHLYIYTAFHRLLPSIENVRPAQLVFLVFYLATFLAVCTIYYLAGRPSNGGRHFPQVLLIPLTLSKRAHSIFLLRLFNDPIAMLIFYLSVIAFQIGGRKGWRLGCVLFGLALGVKMNILNFLPGLLVLLFQYRGIVGTMEGLSIIGLIQFILPAPFFFAKSEPHLLKAYFTSAFDFSRQFLYEWTVNWRFISEEAFLSRERAVALLAGHLTVLGLFAAFKWSPVPGGTLKVLQKGFSNPLNQALEVSQVPAYHIPLVLFSANLIGMLFARSLHYQFHSWYFHQLPFLLYSGAGWGNTLTSVMIWVAVQYAWETAPSTISTSIALLAGHGAMVLGLVFHGMKQLSSKQKFKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIC6</accession>
    <name>A0ABR3BIC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610711.1">
        <property type="nucleotide sequence ID" value="XM_066761171.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993605"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1415" mass="157875" checksum="74A8B77E215ACD9C" modified="2025-10-08" version="1">MRKALDISRLTRPARIRCRPSLFLRRLLSSSASRSKLSDTPAKASNVKEEELVKPLLPAFGARRAEMEDYMLAMEMAKLEDGYAQPRVRKIRKAKLPSLHDPQSFLWDSKQASSSKVVSSARTSQPSRKGKEKEVVVDGYRASKSDQDVKSLKDAKPINLGESKIGPRRNPVGVQMLSPTLHSQLFPGHRLPKPPQALLDISKCHLKDNDLSPEGAAVLPEISFDLPPLRGNNVRDHFHALGRYTAEPYASMAKTFAATKLPGKPDRWEMERPGWTKYYSDGRMEAVDDLGDETLVSFDVEVLYKLSRFPVMATAVTPNAWYSWLSPVIFQPPPAEIPESPPPWEASTLTCHPHELIPLFNSKSSIPRIVIGHNVGYDRARVKEEYSLERTQTRWLDTLSLHVSTRGITSVQRPAWMAYRKNKKAKKLREQENLSILQEMAEKSGDRAIMESLQEFGAASETEEAEALQSRWEDVTAMNSLAEVAALHCGYAVDKSVRDSFGDDSIKHASQIRSELHHLLSYCADDVRVTHDVYAKVFPLFLESCPHPATLSGVLAMGNSFLPVDQSWKEYLRNAEETYREMDAAVKKALRLLAEKLKAEGEPKKGDPWASQLDWSPKTARWSDEDLEGTQKYPVQSPEDAQPLKPESSSSASSPAWVTQISSNHSVLKSNMSQRYLLPLLLRMSFKGHPVAYLSEHGWCFMVPHDQVGDYFDTHGSPHMLSTKDKKLEKLEESYSFFRIGKAGSPKKVKLVGPSIKPFVNSGELTSAYPELLAKLTKADLSDVVEDLWECVADMGNFKESEWGQQLDWTPVTEASGLRTSPTKKSKTNLVTWPKWYWDLTGPVSRLPVGELDLTCKKTIAPLLLRLQWQGFPLVHSKEHKWLYRVPRKVYNEEDERIAKARGLPVSFKIEGPDSVFAKDDDHIYFRLPHKDGEGKNVGNPLSKSFVKSIESGELASAAAESGDDVAAKAATDATNMNAFCSYWISSRERIMDQMVVYRDQEFGMILPQVITMGTVTRRAVEATWLTASNAKKNRVGSELKAMVRAPPGYSIVGADVDSEELWISSVMGDSQFGMHGATAIGWMTLEGTKSAGTDLHSKTANILGISRDAAKVFNYSRIYGAGKKHAVQLLLQGDSKLTKETAGKLADNLYKSTKGAKAVRARNLPLASLPSLWHGGSESYLFNTLEAIALSDRPTTPALGCGVTRALRKTYLNENASYLPSRINWVVQSSGVDYLHLLIVSMEYLIKKYDIQARYLLSVHDEVRYLAKEEDRYRAALALQIANAWTRALFCFNLGIDDMPQGITFFSAVDIDHVLRKEVFLTCETPSHPKVIPAGESLDINALLEKIPLGDLGTPIPDDLQPSTNIKPPVALFPDIQSTRHRVFLQAQASKGGMAAKKWLDDLPPVVQDTDESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIG4</accession>
    <name>A0ABR3BIG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610984.1">
        <property type="nucleotide sequence ID" value="XM_066760712.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993134"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF108">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="448" mass="49016" checksum="1D4557AEA1DF160D" modified="2025-10-08" version="1">MDPTLTPGDHTPFPHQIAGHPGVMSDPSGGLLIKPALPREIAFYQMLSNSDPEDIVWPLRKFVPKNYGTLRLEGRLGAGGAIETDLDMKNETPESVVLENLAYAYTRPNIMDVKLGTVLHAPYATDEKRQRMEKQARETTTHETGIRLTGCQTWHAPTQGYISTPKSFGKSITTPELSLGMVRFFPLPTDSIACLVAHPTPPPTAVEVVSSTEASHLPIPAEASCASVIQSATSISIPISPPTPISPEAATTATTTTTTPASTDLETLPTYKDHSIPPRTLARLLTLLLQKLDHLTEAVSTLEMRFVGASLLIVYEGDPVRLEAALDREEKVGVKKESDGKENGNGNGDSERSMFSDDGSIDSDSDEDEDDEYDSDEEEGYDSEDDLDGKKKDERRARKCPALTLKMIDFAHTWLAQGEGPDEGVLKGLRTFRSLVERRLEEVERSCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIK8</accession>
    <name>A0ABR3BIK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein ORM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611022.1">
        <property type="nucleotide sequence ID" value="XM_066760750.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993172"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30162" checksum="43C422A198649457" modified="2025-10-08" version="1">MSPPSATLTLSPHSPARSRSVSQPIPEDAALDTLSPPRLSSSRAAALRSLSSNSVSRGSLPFLQNHTHSNSPSPQFRASKGRARSSSLVTVTEVGGDDPDNVVDRLGAGNNENAAWVNAPGAWLIHPVLICCGKLLIDAIPGMTQDVSWTIVNLSYITFSFIMFHHVTGLPFESTMTTSGAYDDLTLWEQIDSGAQYTPAKKWLTSVPIGLFLISTHYTRYDYVLFALNFAALIFVLFPKLPVLHRLRFHFAVNNDVPQTPVQSRPPSPARRTVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIL9</accession>
    <name>A0ABR3BIL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610816.1">
        <property type="nucleotide sequence ID" value="XM_066760991.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993422"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044976675" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="544" mass="61340" checksum="B8D9172E44B2E874" modified="2025-10-08" version="1">MWSKVVTAALLAIALGSIIEARDFHNLRGRGSPALATDKVAKKEVLTTPKSKTKDKCHARPERCPETKRFYNDKTSEFFVESLPDVPFDLGEIYSGLIPIDYSNQSESLFFVFQPKLGECSDDLTIWLNGGPGCSSLIGFFQENGLWTWQPGTYAPVINPYSWVNLTNMLWVEQPIGTGFSIGTPKATTEEEIAQDFIKWFKNFQDIFGIKNYKIYVSGESYAGRYVSYIGAAMLDQQDKTYYDLSGALVYDPAIGETIFVQEQIPTYPFVEANANLFNFDKTTMAELKELHETCGYQDYIHRYLKFPPTENQPHLYYDYFDYDNATCGIFGKVSAKAPRINPCFDIYAINQMCPLLWDVLGAPTQLDYAPGGIYFNRSDVKAAIHAPSHIDWTVCATKPVFVGGENGPQSNGDLSLDPIQKVLPQVIEATNRVLISNGDFDYVILTNGTLLSIQNMTWNGQLGFQSAPSEDIVIDIIDTQWSSVYEANYREGYPGAQGVMGIQHYERGLMWAETFQSGHMQPQFQPRSAYRHLQWLLGHIDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ99</accession>
    <name>A0ABR3BJ99_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611246.1">
        <property type="nucleotide sequence ID" value="XM_066760485.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992891"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="30"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0241864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="196" mass="22551" checksum="93B81795C0F8A52D" modified="2025-10-08" version="1">MTELKAYDKMSKEVRDVHDQQQREKEKKEQAELPYSWTQELATATVTVPLPKGTRGKDLEVVIGKRKLKVKLKSSPLPILEGELYNDVVVDDSSWTIDDGTLTIELDKLSFHIGSPQWWPHILTHHPTIDTTKINPAPSSLSDLDPKTRGMVEKMMWDNQQKALGRPTSDERRKEEVMKKFMAEHPEMDFSKAKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJL5</accession>
    <name>A0ABR3BJL5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611363.1">
        <property type="nucleotide sequence ID" value="XM_066760602.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993010"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0241981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1103" mass="124210" checksum="C2189018E241BF13" modified="2025-10-08" version="1">MYAPPGFDPDSSGEETTPPPTPAPSPPPKPQFKFRSLFTSTKKLEARTLRQAEELKKDEEKEPPGPMKKRVRIFAGELLGGQKGSKVEGLTTTTGEKIEPEPPSPEESKQESKSEPAGLTEQTAINPVASEILVLLRQLVVECQATNKNTGPEPKADSVSQGMNEGSPANGAEPEKKIDLPAPEAIIATDRKFDRPIDTEPAQETHAPQHRPSHLLPTSVNKLCHLRPPHTAPPYGYYPQLASPYLWTAYHLRLQWLPFDHHSTSDEQKTVTKLSPPHFTLFDPVISESSRLPLNPYVRKYEDAHNRALKDYKEPVLEQGERKRRKEKVRSAERRLNETRQALEDTEWEAGIGDDSGDPSPNERYQGENDTTPAADNPTKPDSTVIDESRALERLETYVVKYRQSYNIAVKRSRASEDDDERKERKAIVKETQGKLREAMQALNTAKRVKRSLTNAAEKEASVKKKLDKWKGRAVNVEGEVEEPKRTKEDQEEEGRDLQKVPMEISPSVQEPIYEILMDENVVENGGNVNPSLQHPIEHYKIKFAAVAEPSNEASLNHERKQVKMEETDRVKKKKIKALMFEDEAGEQASKAKDVGNEAKCSATKPFSDMKEVEATASMPKHKGSPHLETSPLPSIIEACGAPAATAHDRQLRNKEADRLKSKVQMDIETLLELAKIKYSKFAKAVKDETIGDETRRKRKAKVEKQALIVQAMMKAMDKTTNECKRQAKTGKDEMVSKEKAQILSRGMILEEVEQAIGQVKEERQTEKMNNSMTEEKESRQCPLSGCKAAGSCKKPRPTIAISHPSVPLDVRRWFDGEGPEELTWSKTLVSLAKWVDLCNTILYSLQFDTRANSNHVGTILSRLIDNLLRQQDLVDSMRKLAGHGHDAQLKEFMEHLAIIKGFLEKTMSSGLTDYFEREVDKVSKDVERGRQSLEVASLHKVFEFLVSVTEYLTPGVIFIMRKTFDDWRVNGFTSKSVIYAIVEIRKEIASIHQIERKERKFEEEEKDKTKGFLGLLDMLLAFVASPDIDPIITEKNDGGPGILANETPVSTQLTVTEHNDETVASEGKFPLSEKTIVDSPPHKLLIFTIYLTFSIFPHPYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK70</accession>
    <name>A0ABR3BK70_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein disulfide-isomerase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611572.1">
        <property type="nucleotide sequence ID" value="XM_066760268.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992674"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045162775" evidence="7">
        <location>
            <begin position="23"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="14"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="148"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0242190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="571" mass="63850" checksum="D36BCDC1B4CF8087" modified="2025-10-08" version="1">MRLPHLLSATVFLSALFTKATSASTDLDDDFQLRQLTEDNFKTSVSQGVWLVEHFSPKCGHCRAFAPTWTQLAKDKQHLERLTGFHMAQVNCLAQGDLCNSNGIKFYPQIIMYTDGKPSPHYTGDRSYEELSKYIDENAHTYAETILDPAGQSQEALIIGPANSEGKVQEVDERGLEALKAEGPVLVEYFAPWCGHCKALKPTYEQLALELQGQLNVAAVNCDDHRALCVNSGVKGYPTIRLLHHGTFSEFSGARSISKLKKFSQRAEKPASMTSIKASDFDKIAGANEAFFLYLQTFDTTVAEVDSVKKALEPLLGTVPAYTSTDAALYHRLHVVNPPPTSTLFAFSSYSTRPVGTLSLPASSNDLRKFVNLHRFPTLVQLQASNFQSLMRSDTRAIVVLAGVHKGEEGKKERDAFADIARAWKRGGRRFEQPVWFVWVEGETSRWANWLKRFYGIKKRDLPGVVVIDTPLEEYYDTTIEGTKIEFEGSSIFSVLEGFYQHFLRPKRIESTLEWGSRSASETLISIGETTMEHPFLSLTVLIGTVALFVYLLQKCLVKDPKDGYSPSRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKB0</accession>
    <name>A0ABR3BKB0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_105811</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611564.1">
        <property type="nucleotide sequence ID" value="XM_066760260.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992666"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046578837" description="alpha-glucosidase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="12">
        <location>
            <begin position="138"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="11">
        <location>
            <begin position="325"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="13">
        <location>
            <begin position="755"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0242182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="972" mass="108279" checksum="A6609FB02C98DFF1" modified="2025-10-08" version="1">MALLLQVLTFLLPILAGATPAYRPATLESFQPRDYSSWAVASQQPDFSGDVTQCKGYAINSDSITRTSTGGISAQLDLITYCSAYGKDIPSLTLSVEYETSSRLHVHIYDTPVKQFQIDDSILPRPKRTLFGADSADKSDLKFDYENSPFAFWVTRKSDGEILFDTRKDGIPIHEDPSDILGTPSNYTVMPAHPLVFEDQYLQLSSKLPVGANIYGLGEAVSGSGYRRNSSSTVQTMWARDIADPVDENLYGTHPFYMEVRYNETACTLASHGAFLRNSNGMDVILRDGAIQYRVIGGTLDFYFVSGPSPNDVTEQYVSTIGLPQPMPEWSFGFHLCRWGYTSANETLSVVNRMRDAGIPLETQWNDIDWMRSYREFQFDQNYDEADYRNLVETLHSRNQHYIPIIDAAIGHPLNATDRFDVYDKGHELGVWMRNPDGTEYVGAVWPTFAVFPDWFHPKMQEVWTEAFYNLSQIVDFDGIWLDMNEPSSFVDGSASNSTMSLENTTVVPPDYSTVPFPTSWPEGYSNVTGISGNVTVDGALTYGADGNATKNTALRRSNLVRGDDILTIPYVDVPPYPINNGNGRLSAKTVSPNATHYGGLQEYNVHNLWGFMEEEATNNMFLDLRPGKRPFLVSRSTFSGSGRKTAHWLGDNFSTFAYMKRSIQGVLQFNLFGIPMVGPDVCGFNGNTDEELCNRWMQLGAFFPFFRNHNIKSAISQEPYVWDSVRDASIKAIKARYQMLPYWSTLFAKASLAGTPAVIPLFHEFPSPSYLDNDYQFLIGPSVLVTPVLQPNESTVVGQFPTAHDVFWVDWWTHCKLDTSSGEDVTLDLPLGNIGVHVRSGSALLLYDEPGYTVKETKDSGYAILVVLDGKGYAEGDAKIDDGESLPVTEQTCLTFTSTDSCKLSSTADGSYTIAGKLRTITIVGVWTKPSEVTFNGSKINDSQIEFDEGVGRIKITGLVEDLNSAWELKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKD0</accession>
    <name>A0ABR3BKD0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105877</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611630.1">
        <property type="nucleotide sequence ID" value="XM_066760326.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992732"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="5">
        <location>
            <begin position="3"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="95"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0242248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="186" mass="20975" checksum="BB2E54F5C025923B" modified="2025-10-08" version="1">MSQKQLFAAFDVSRQVFYRSALSVGIINLKPLLPGHVLIVPKRVVPRLADLEANEVSDLFLSVQHIGKVLEDVYKARAMTVSLQDGVAAGQSVPHVHVHLIPRHRTDYDGKNDQIYPLLEQSENLLHGDLENSDVPAVNGNVEHDGQTKAQVGKWKVPKDEDRKPRSTEEMEREAIWLASFFQKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKK9</accession>
    <name>A0ABR3BKK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105952</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611705.1">
        <property type="nucleotide sequence ID" value="XM_066760401.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992807"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="252"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="107"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0242323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="351" mass="38637" checksum="52733231849B1E3F" modified="2025-10-08" version="1">MARDRLGNVNRQYGEQPTPGPTYPPPGNGVVAPTRTANPYAQQTSVAAAAPGGYGAQGGYGASAGNPYAQTGQAGNPYATGGQYGQQEQYAMGGVNGGAGEDFWTELSNTNSLLSQLQEQIQAVRTAHQTSLTSTDPQAAAYAAQLNDQARVQREECKNQIKTLYKLAKGDRAQKTQAEGVKSRFQGLLQEHQVIEKEFRKKVKDRVERQYKIVNPNATEEEIREVTESDNPQVFSQALLNSNRYGAARGAYREVQERHAEIQKIEKTLTELAQMFQEMAMLVEQQDETIVNVETQAHGVDTDIKAGLVQTDKAVESARRARRKKWICFWIVVLIIVILAVILGAYFGTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKP0</accession>
    <name>A0ABR3BKP0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611551.1">
        <property type="nucleotide sequence ID" value="XM_066760247.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992653"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="1131"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="1166"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="1312"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="1347"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="1412"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="947"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="954"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0242169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1463" mass="161306" checksum="2CF64551A5EFB692" modified="2025-10-08" version="1">MFTKATSHLRPFIRLPSSHSPASPDHFTANPSLLHHLPQHGTSNSVIVQGQHSAQAGGASGHAGRTGYGGGAGAGGGYTGHARAFLSLPQTASVNSSTFSDERKKDASSSSSPNTSLLFKHRLSKAPRIVHLNDSVRARRAIEERKGGKDFTVVELEEVPKIHRRESITEFTSGRLPLSSTSTRSLSRSYTSFDLFQVGIPQPRSIGLRALSTRSNAPRALEAEDIEAIEELELVSPRAEREIRTIGQPNRMLMDLAGRDLPSAVAAGWRLGGVRRNSTAAVERPSLDLPPANLSSIAAPEQKEDKQREETIFQALREAKQNGNVELVKKLITHYRSPRSLPPFSPDSLPGVPELSKHYPLPSGFSIRIYNACLIAALATRSPGQSIAPILEIYNELLEKDIVPDSMTYGAVIRALAMREREVRGSQEIWERQKTWGLWRAEIAGNDSWDPELAAENDAAIEAYLAENNVLSAVRLFRAAALTGQAGRFVVSIHGTVLDAMSKLEKPDVTVMEQLIEHAESHEVPGRISLYKHLFVAYAKIKDASALSQIWDKYRDLAKTASREDWAAACGQRDASHDRIEGTMREPWDIVLSSFIEVGELSKAFEVFGEMAEVAEKKIESEVPSATHRTCGVLVTSLARAGELDLALEWFNNLQASAIVTENLPHRLTLEHTIVLAEQLLLKGRWFDAADIVVKLGAIREELTQSSAQHSLRTVAWKTNFALIHHAARSTAEEAARTLARAQEVLTAVPIQLDLRSIVLHLTLLAQAGDFTNMIHVLDLISARRLPANTILRLNDACDQIAKEDIPFKYRVELTKAFGRHHAELTSFVAEKLIEAYVSEKGRSVDERALNKDSLYTLIDAFTVIEQKRVNEGEFDEALEQLMKDLAVIDVSEDMKKANSNQAVGYLVKNLIFRFGAERARSMLGAVFGDQEAANLVQPVSPAFTESETVSKNELSSEAASPSQSHASSASSAPALSFSQTLTSSIERFTYRNPTITPLEAYALLRDGLSVSQVPRLEVILSLMDHLARRNDEPKVRELYELAQLVLNSLVRPDVQAQSWYSTENAMLIACCHLGYLEEAGLHRARIVQAGFAPSADAYATMIASSKDTTDDALVARELWEEALGMGVKPHLFLYNTVISKLSKARKAEGALDLFMRMKSERIRPSSVTYGAVINACCRVGDALSAETLFEEMTSQLNFRPRVPPYNTMMQFYLQTQPNRERFLYYYSALQRARVPPSAHTYKLLLDAYATLPPIDIPAMELVFSHLIADKSVRVQGTHWASLISAYGIHAGDVKKAKEVFDKIPEQGGNYEAVVWEAWLNVLSQQGSIEQLEEAHTKMLESGVQPTAYVYNVLINGYARAGNIGRAREVFESMGDSVTGVAAPNNHPVLLTSSGHAKPSTQAAGTGVVYREPSTYESMIRAEVTCGDKQRAAEVLQRMEERGYPMAVYMRGKAALEGEPPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKX2</accession>
    <name>A0ABR3BKX2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610890.1">
        <property type="nucleotide sequence ID" value="XM_066761065.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993497"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045398578" evidence="2">
        <location>
            <begin position="18"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="225" mass="23396" checksum="A3109334121CDF03" modified="2025-10-08" version="1">MRWLDTLPLFLATVANASPIQRRQETSAATVPWATLGPASTKGGGESAVPWSTLEPGTPIVPASTLVPASPIPTKGSSLDPRKEMPAESVPWATLVPAQTKDVDESAMPPSTNVAQTSVPWATLVPASTKDSHESAVPWSTLEPGTPIVPASTLVPASPIPTKGSSLDPRKEMPAESVPWATLVPAQTKDVDESAMPPSTNFAQTSVPWATLVPASTNVPKSDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL91</accession>
    <name>A0ABR3BL91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611364.1">
        <property type="nucleotide sequence ID" value="XM_066760603.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993011"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045202619" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="3">
        <location>
            <begin position="468"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0241982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="651" mass="69225" checksum="A7C2BF210BD4A419" modified="2025-10-08" version="1">MTLLPQMPIPFGLVLVSLLSVFSHTVFAGEMTLYTDTTPTTTSSLAPDETYTGLAAYDPTRLTPPSPPSPAVTSGFPLYPFRWHWSSKPRFIIVQTSQSLLGSSSGNLKVPFLNFMANIQNRAGAGPIIRVGGNSQEGSTIFVDGLEGGVAMEKIKVSSGVTDTPLINYSPELFYIMSNITSLVGAEWYFGLAFNESDVDAPTGNIPLAAHWAQEILGDSLLGLSVGNEPDLYVGHNHRSAGWGVSNFVTEYDDMLNSIVSNGSLLNNNAFLGPSLCCNVAGFEFSDVINAGWLDQNVDRLSAVTVQHYPTNNCKVNGNVIAAQDIFSDFLNHTSAQALVGDYLADSVMVQNAGKELVMLETNTASCGGFAGLSDSFGAALWLTDFALQMAYANFSAALMHVGGQNVYYNPFTPPPSNLSSTRQWTPGSVYYSAVVIAEAFGKSNTSKIVDLTPSPENDANYIYHPVYAIYENDVVARMVLFNFIDDSTGGSDLHVTINIQNQSPTQVQVRYFRADSVSEQYDIYWANQTLGHSFASDGRLYGGLETVTITCDGGACIVPVPAPSVALVYLTDAALEESSVSEDVTSTYPTTILGVGSATVDVGSLSTSNGKEGSGKGSTSKSGATSSAGRKVEWMGGLLGLGLLLGAINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLU6</accession>
    <name>A0ABR3BLU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612104.1">
        <property type="nucleotide sequence ID" value="XM_066759457.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991853"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="33"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="307" mass="33606" checksum="6D5899D23A0AE333" modified="2025-10-08" version="1">MSNVQALTPYRTHRPSDFKGSPVVHSFFDDATSTWTFVVADPQTKCAMIIDPVLHYDPASGGTGMRTVQGLAAFTLEAQYEVVRIMETHVHADHATGAFALKTLLPGSVPIYIGRKVEQVQQTFASIYGYKKSDFMDCFDGFVDDGDELKLGELTVQIWSLPGHTPDSMGFLVGDCLFAGDSLFLPDVGTARADFPGGSAKSLFKSIQLVMRLAGGSRVFSGHDYPVGREKSCMSLMSEQSRLNKHVGGSTTLEAFIKMREERDAQLATPRLLHAALQINLRGGRMPLPDAEGRRFIRVPLSGDFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMA2</accession>
    <name>A0ABR3BMA2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612289.1">
        <property type="nucleotide sequence ID" value="XM_066759642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992041"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="164" mass="18552" checksum="0DA2ECCC3A183BE6" modified="2025-10-08" version="1">MKRRKRLLISVTPPTLKKRVKKRRTFRPGRCANCGCTESGQQGTSLWRTNVDAEDDTGKIVCNACGLWRAEHGFPRPKMCPSGSTYSNSGPPSPRKRKFLALNIRKHGMVEDSISEDDVSDDRTDTDEVTDAAFTLMKMVFKVLTDSPDVFRPKEESWDDIITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMG5</accession>
    <name>A0ABR3BMG5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_105413</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611814.1">
        <property type="nucleotide sequence ID" value="XM_066759868.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992268"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="69"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="370"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0243447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="642" mass="71308" checksum="4049EE360FBFD81A" modified="2025-10-08" version="1">MAFSPSLTPSRPAPVPPRRPAGTTPHTIGVTDTAAAPQSNFSSTSYSPSFSYTNSSIHSTKVADTTRSRTIRSGAASIKEEGLRAFMWSKRWLVLGSAELRIYKNESSSSPVYTVSLEDIQDVQRVDLKPYCVEIETSDKLLYFAFRSDNEVYGWMDDINSRTPRLGVSQPTNFVHQVHVGCDPKSGGFTGLPPQWSKLLTSSAITEEEAARNPEAVLDVLQFYTQQQASDVLEGYQKFPLPSVSNQFLTTGAAATRFEGVGLGGQQQQQRLRSAPFTATGSLATTVASGQRSFNTETKTLAQKEKKIVLNPQRQLLDSVTRPPMGKNDKEKIIRSPGPTVEKRISTMNEVQIMEKLRSVVSAKDPSQLYSKIRKVGQGASGMVFVAKTLSNGKKVAIKQMDLSQQPRKELIVNEIIVMRESQHPNVVNFLDAFLVRGSELWVVMEYMEGGALTDVIENNKLEENQIAAICLETCRGLQHLHSRSIIHRDIKSDNLLMNTQGEVKITDFGFCAKLTDQKSKRATMVGTPYWMAPEVVKQKEYGAKVDIWSLGIMAIEMIENEPPYLDEEPLKALYLITTNGTPTLKSPEKLSQDLKHFLSVCLCVDVAFRATSTELLKHEFLQLACSVQDLAPLLRFKQDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMG7</accession>
    <name>A0ABR3BMG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 14">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_105225</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 14"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612329.1">
        <property type="nucleotide sequence ID" value="XM_066759682.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992081"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021162">
        <property type="entry name" value="Dot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017570">
        <property type="entry name" value="Histone_H3-K79_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="16">
        <location>
            <begin position="297"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="25"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR017570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0243962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="642" mass="71112" checksum="F263170C085547B0" modified="2025-10-08" version="1">MFSFFGEESKLPASTVMIGSIAVKKQAPTRQQSSGSIAGPSKSSNVTPRHSHDSLEGASRSASAKSISKQGPNLSSNSTAKVKQDERIKPPATPRTPASSSSPGRMKRKTPKVQVVESESSSGSESSDDALDPKPKRPKVTRKETGIDMPPLPGEEVVDRWVFCWDKVDMRGEWGRGWAGFVGCDEVVRGNVQGWANGGGGDGSKNLGKYRAFFPQEGFDRDGDFLPSVEVLYPAKGCREKFVLMVPSSDREFNPIGELRNTLRLILEHYIPPSHRHIFGTLAESLDISNPLSALPSRMTTPLPNLLVTPPPDPASPSPAFETSATSTPAPSSERQETIADLIRKSLAPNRRDGPLFVTAIERYNSAMQAIQEDGTLQQWLDEGMNGGKEIKVREWAALVDFVHDQAYSRVVGGYSHELEHHPKHPEEVSKAISGKEDAYGELRHAFMTKIIEQTKLGSDSVFVDLGSGVGNCVLQASLQAGCRSYGFELLPVPAHCARLQVREVQRRWAMWALKGNLDVQVHEGDFRVHKEVGRRLREADVVLVNNEVFPSSLNMDLADMFLDLKEGAKIVSLKPFVPEGFRMNESNCDSFAAILRSTQHDYYRDWVSWKGEWGNYYVAVIDRSRRIKFEESMMGKASRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMN3</accession>
    <name>A0ABR3BMN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612374.1">
        <property type="nucleotide sequence ID" value="XM_066759727.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992126"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0244007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="256" mass="28561" checksum="22CD723A9D31E222" modified="2025-10-08" version="1">MLLRGPLALQIPAQACGKDRLRCFASSARSAARLKGSHYDALMLPNNATKQQIKAKFYELSKKYHPDKTGGDISKFHEINDAYATLGDESKRRQYDISMTPASQSPRRPHASNPAHHSSFHPSDPYLHRAAQGPHRAWHGQHTTSHPPPGWRPKTETYKPFGYRTPPNWQYSPEYNYSHAPNARTTDPAGWGKRRPTQGGREEKHAGGGGVWRFVIVVGLIFTVISLGGSLTANTESEKDWAYESLGENDEEKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN29</accession>
    <name>A0ABR3BN29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="7">AK6</shortName>
            <ecNumber evidence="7">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="7">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611685.1">
        <property type="nucleotide sequence ID" value="XM_066760381.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992787"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="7">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0242303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="196" mass="22544" checksum="1656CDB08863DA12" modified="2025-10-08" version="1">MTTHHPRTLPIILITGTPGTGKTLHSQLLVSELSDADSPIPMKHLNIGDIVKEHGFHEGWDEEWKCWIVDEERLLDWLEEVVNPRDGPAETGFVIDHHDPSLFPERWIDLAVVLTCDNSILHDRLTARNYPDNKISENITAEIMMTCLNETRESYAEEIVVQLQSEGKDDGEVEENVRRIAQWAENWRRDQQEGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN63</accession>
    <name>A0ABR3BN63_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611715.1">
        <property type="nucleotide sequence ID" value="XM_066760411.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992817"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="396" mass="43998" checksum="846057B0D7C9290A" modified="2025-10-08" version="1">MPRPGQQAARRKRARVSTTPIPLTNQEEPGSPNPRARCLPVAELPADFDGIPEDGAQYLAMVMRANEVLPWSTRMEGWTPAVEDETKVRPDNGQPAGTRHMALPQGSWEVLFPLHFQNYRKNLAESWPPSPPLPYPQEYPPLPEANRRSEWYMFINGYPMEQLANPLQKGTKGKEKAPELTEEEAMNEGASNTQNPQGGVNGEPSVELRAKKGKHREPLVSVVQGLNSNEAVRILSHFAHWLTESITQLPPPFPTSPELLPTQPDGPMNPPSPASSSTARPPNPFPPHYTQWILALLMIVDSHLSGGQISTLRDLARAAMRVAGWRWIRGVVTRDVSEGWKLGGQGWRLVTASAENEGGEEESVDEMLARCWVVVHAIVAGWAQRDLLDDLENLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNA1</accession>
    <name>A0ABR3BNA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612621.1">
        <property type="nucleotide sequence ID" value="XM_066759134.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991525"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21790">
        <property type="entry name" value="Rad21_Rec8_M_ScRec8p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF51">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN REC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="655"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0245537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="79530" checksum="EBDA22877A1AA45D" modified="2025-10-08" version="1">MFFSDDLLTSKKGSFGIVWKQLAAVDLARTCDLIAQPPEPMALRLSGALLVGVARVYNQSFDMFYSDVNAFHSSLRRSIATDFRAANGGTATGMALELPGEGRSRPEQITLGGAEFDWEADWTKIFGYIDWNDPLGAMRKRRASSVISSFKATPMSGRQRDDDERHGEDDSEDEGYESEVGRQAKRKKFSASPATTTLHRTPLHPYAPSNSLYTGPDLNFNEEVDLGLNLDFEASAGANDSFSGPSGRDFDIPLAQPDDYDIGLDLEGFGEARPDEEADMGPPAIYDDEPGAQYALYQAQNQERSLNRQSSIETVEQGLESKKKREKKLKTVTFDRALEIDEEEERHARKSYAERMEKEKRDEELKEVEKEIAKKVGRMVDGAGGLEFFDLEMDHWFSRLTHVPKFKWEQDLAQSKNGKKRAHGTDAMDIDAQETGDNRPDFYDNLPPLAEPDDYVYDVFGNIDLGQHDDYGPIQYDEYDIPVRDRNVERGSEALDLEYARRESVQSGNLPWEAGMTGDYTPGFPDMADTSFTPGSLKLSIMTPQEVRLRVHSRSGSLGGRFNQRRRIRSSSLMSDRPDDDPLMLVPGNDSDLDVLPDELDLENIVSSETQEARLVDLPEAFRPEMLATLEKQCRDFFTYVERRMISLERQVIEFNELVPERTSKHIAAVAFYDCLTLATKKILSVDQPEPWEDLNIRFAVKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNF2</accession>
    <name>A0ABR3BNF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104724</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612674.1">
        <property type="nucleotide sequence ID" value="XM_066759187.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991580"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051716">
        <property type="entry name" value="Plant_RL_S/T_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053:SF71">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="5">
        <location>
            <begin position="517"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0245590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="840" mass="90109" checksum="786D596018E9D513" modified="2025-10-08" version="1">MAPTDSSRFSFKSRFSLLSLLPARHPPLFADPPRMPPTQPGPRHETIISDTVSPVHSEYPDLGTPFPPCRKKSYDDKFPRTWEHDEKKEQIKEKKWRAKRPPPLNLERTHMMYPSSSVDVVIDPGTPSNPPPPHAPPLPKKINPKKRRQLVEDFFEVAEVEIGHRYPSWKGGKADIRPGQVIPPEIMPPLVDLDAKPKLKSKPKRRGTAADTPDNYDSVLHNVLLTPTYIAPSPQVNSTLTPSPYDPSEFIEKYNRPGTLLDRATDTISNAAQRTSKWMPGKSILRGGANNDNRAANESFRILGKRELEEMARFRQKKISGVRLAVPGDMAYSSGSSPMKEMSSICSRKSPGWLGSRERKIGYDGDGKYPVMIGTSDKGWRAEKRDEERAERNKRIWKVAIILAILFLVALTVGLCTSLLRKSSSSSLGNSSPSDVASADNSSGSATVASSAASASSTSSQTLATCLGLFTSSVSTSPTSYPCSDCVQVLRSTINDFSEPIVNGNSTGVGSALQFCAMMDIYNNIENTSGLSKWGADASPCGWDGIGCDSRGRITSLSLKYPNVPTALPNTLRNVYGLKALHLLGNSSVPTGDFPSSLLSLPYFETLDLEYTAITGKIDTAPFSSATGLVTLVLISNPQLGTSMPDLSSNIKLVTAAVTGQGLTDAKVNKLPSSLTYLDLSYNSLSGQIPSLIQLAYLKTLYLQNNHFTSAPDSLPPSLTTISFTSNPDLSGTMPSSVCLSTVLSLCDLRSTSLTAGTTLSSSRSNSSSFLNSVATSSTVTSMTSISSSSIKASSSAKSRTSNISGSSSITSAASVPSSTIIGIVARASTDGTCGVCQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNV4</accession>
    <name>A0ABR3BNV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612842.1">
        <property type="nucleotide sequence ID" value="XM_066759355.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991750"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44192" checksum="8CC898F97E65133B" modified="2025-10-08" version="1">MDPSLPLVVDNGTGFVKCGWAGSNFPDHVFPSIVGRPILRAEERLGTSQLKDIMIGDEAAENRSYLQVTHPMEHGVIKNWDDMRHLWDYTFNEKMGVDPRGKKILLTEPPMNPKANRQKMCEVMFEEYGFGGVYVAIQAVLTLYAQGLQTGVVVDSGDGVTHIVPVYDGFALPHLTRRLDVAGRDVTRYLIKLLLMRGYAFERTADFETVRGIKEALCFTSYDLEMDKKLAEETTVLVENYTLPDGRVIKVGSERYEAPECMFQPHLVDVEQPGVAELLFNTIQQAAVDTRTELYKHIVLSGGSSMYPGFPSRLEKEMKQLYLTRVLGNDTSRLKHFKIRIEDPPRRKHMVFLGGAVLADIMKDKDAFWVTKEEWEEQGIRALDKLGRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNY1</accession>
    <name>A0ABR3BNY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="2 10">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104913</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="2 10"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612861.1">
        <property type="nucleotide sequence ID" value="XM_066759374.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991769"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="240"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0245777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="597" mass="67471" checksum="F650A48A7F8D24F2" modified="2025-10-08" version="1">MSAPAVEANLHKDEVTGEMISKSELKRRQKERQRAAQKAEKAAAAPAAAQPKKQSKADAEAEMDATAFHEMRYKEIAKLRETKQPNPYPHKFNVTHAVPKFVEEWGKEGKLEKGETAQLDNPISLAGRVYTIRESSSKLRFYDLKADGVKVQIMAQAQNAASLEEYLDTHDRIRRGDIIGVTGIPSRTKMGELSLSISSIQLLSPCLHLLPGREGVVDLETRYRKRYLDLIMNPSTRDIFVTRSKVINYIRKYLDAQGFLEVETPMMSMIAGGATAKPFVTHHNDLKLDLFLRIAPELYLKELVVGGLDRVFEIGRVFRNEQIDMTHNPEFSICEFYMAYADMYDIMDMTEELIEGMVKSLTGGTKLIFHPQGKGEGKKVYEVDFARPWKRFDMIGELEKQLNVKFPPGETLHDDNANKFLRELCEKHNVDCSEPKTNARLLDKLVGEYIENQCVNPSFIVGHPQVMSPLAKYDRSRPGLCERFEAFLCTKEICNAYTELNDPFDQRERFMEQVKQKEQGDEEAQGVDETFLDALEYGLPPTGGWGLGIDRLVMFLTDCSNIKEVLLFPAMRPIVANSVEAVAPSVTATEAAKEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP35</accession>
    <name>A0ABR3BP35_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612926.1">
        <property type="nucleotide sequence ID" value="XM_066759439.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991835"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0245842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="77" mass="8686" checksum="D4C63B28424477B5" modified="2025-10-08" version="1">MVRAMVTRLYKTKPTGLFVRLPSFQRTHPFIFHISFTTKTPSGTMLRTCALRIHVSPSYLLGTSSSLPVLLFSSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPI8</accession>
    <name>A0ABR3BPI8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613076.1">
        <property type="nucleotide sequence ID" value="XM_066758628.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991006"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF7">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="60"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="331" mass="36826" checksum="A9FC60956E1A83ED" modified="2025-10-08" version="1">MSIVINPATTKPPTRDNANPPTHLPVAKTEKQHPSKAGGENASVYFVGTATTILEWEGIRVLTDPNFLHAGDHVHLGPGVSSTRLTNPSVDLHDLPRIDLVLLSHYHADHFDQEVEASLRRDLPIISTAHAKKALSSKGDDSFTNVHDLEPFQELMIDVKDDKTRKQPRIRVTGMPGKHVAGAMEILNEYVSAIPPTNGWMVELGYENDNIFKTGYRIYISGDTLMVNELKEIPKRYPNHPIDLMLIHLGGTTVPSPKMLPLAVMVTMDAKQGVELMRLIKPDVTIPIHFDDYDVFASPLEDFQKLVQQEGLGGGVVYLDRGEKYQFCVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPN7</accession>
    <name>A0ABR3BPN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_105543</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611943.1">
        <property type="nucleotide sequence ID" value="XM_066759997.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992398"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="237"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="704"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="763"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="394"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="460"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="528"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0243576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="807" mass="92868" checksum="3D437E3748C4A37E" modified="2025-10-08" version="1">MHRGIPSPPATRRHTATQHTPWENRVPPSAYGSARPHSALLESTPHDDAELPLYKDTNMELKRRFEEKQPVQLEQPVVDDDQGKWEKGYGAGPGIGGRRGLPPKQRIPGWKGIVLEHEEWVWAGVYTLLSMITRFWRIGAANYVVWDEAHFGKFGTHYINRDFYFDVHPPLGKMLVGLAGLLSGYQGNFEFKSGVAYPEDVPYTAMRVMLASFGVALVPLAWFTSGEMGWSRWARHWVTICVLCDIGWLCISRFILLDSMLLFFTFTTTLGLVKFRNQRHVPFSDDWWIWLVFTGWSIGCVCSVKWVGMFITALVGLYTIEDLWEKFGDLSMPIRTYITHWIARIACLIILPFIVYASCFKMHFLILNRSGPGDAQMSSLFQAHLRGNDFAESPLEIAYGSTVTLKNYGYGGGLLHSHVQTLPVGSLQQQVTCYHYKDENNNWQIVPPWGADPVDPDGPIRFLKDGDEIRLVHTQTGRNMHSHAIAAPVTKESWEVSGYGNLTIGDANDLWVIEIVDDTHTSKKNNENGRIHSLTTRMRLKHRELNCYLRAANTVLPQWGFKQVEVSCTKENNPKDLHTYWNVESHWNERLPPGNAKLYKSPFWRDFVHLNVAMWTSNNALIPDPDKEDILASEPFDWPFLHLGLRMCGWGDHQIKFYLLGTPIIWWFSTVSLAIGLGLAAWYVARMQRGYKEWKAGEWDHWLWVGKVAFGGWALHFFPFLIMGRVTYLHHYLPTLYFAVLMAGHILDHFFFASPTRSHTKKLIWFTVWAGVVILSFWWFKDLALGIYGNVNNHWGWGWRSSWNIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPY8</accession>
    <name>A0ABR3BPY8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613199.1">
        <property type="nucleotide sequence ID" value="XM_066758751.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991129"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047325487" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10796" checksum="79396DB0D5E2372F" modified="2025-10-08" version="1">MRFVRGLHFIFYILDHLCFINKSDTIRSEKKGKKVQQRVEKVQDVYSVCSCPIYEHVHTPLVSLAVSSADKNNSFESFWPCTAHGPLHNDSQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQC3</accession>
    <name>A0ABR3BQC3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613334.1">
        <property type="nucleotide sequence ID" value="XM_066758886.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991265"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="904"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1253"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1673"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1759"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1253"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1673"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1767"/>
            <end position="1783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1797" mass="195500" checksum="23D2A385E04372E4" modified="2025-10-08" version="1">MVNSFILSPNRQSRDLNFLQSISNQPTGTGSNTGFKASLRKIPSTLFHKDKTPVKEKPGRKKLQVYSQQPNSHMGMSPLLRVSRQTLETDSQSETKTKAKQTKPRKGLAELFGWSNHSYAQSAQPAQPAQSAQPAQSAQPPQRIKTLVPVPTPKEYMISKKHNGPPSTKSNSSHFVSLRPPAEPAMPSRPSMGDDPFMRPEEGAEVVDHFLRHGTASLRSMKPLDKRSSVTSSKALSCKTTLSDERSIKEVHDRPYFNPTMHATQQSHVSASPSQTTSNDPSYAYIRKAIGSEFKMFAPLPEVPEASVTLIEPPKKTLSKEKTKSKVWVFLGRSKSKMSKISTDDQPVTPLPLVKDTWNVAPLPRLAQSSTSLVDKIDEKYPAATTRSNYSSFQCSKHPLPSLRVSQSSVQHPAQDGAIGASTVAVPHSAERALFDSPSKHPLTSGMGGVWESIVGSVADRPSKDGPLAAIEGLMRPVRLPKRKSLSSLFGLGARKDMDKTKPSSPIRAPSSMSGQLVLESLTEEVEESAQELRPVPTSAASDVFTSRLSVLAPPPKQEKDGGLRRVASATDKLLSLVHVFDFSPVSSNSPTLHLSSSSTSLRQGFDGSPTPIRKIRSAVLIKRPNANCLRSPSVNVSPLKLPLHRSQAAANKDVQAKTPERSETIIDSSPRQSMVRKGMRNIFAPPSPMASKYIESAEVPTCLAITNLTNETVSTNQILGPNILYQNTEPTRKVKDASDVPFDLKAIVANTEASEAKHFANKTVHLGLPAAPPQNRISYRRPGPSPPALSLPPVPDAILPEVESISRLTPEVNDGYSAHDSMYLDTLTADFNENRNSFDFTSEYQALDQGTQRASFVEALKKVGSVHMFMGGGLPTMPAAATKEPAISAVDQIPSFHIQKPSDITTQHVADSDSNDSDEEGEELCDEESFEHVAEIHHVMGIARTSPVRREPFKGQVAFQQHMSMKQQPSHASFGAPEAVTPMELPPIPAFPLPPVNFEPGGHKRAESSVATMSSIGSVIGTGTEREYTNYFDYVLPSAQSHSRQPSVAESVGEVINGGSPRHSPSRESLATFTFGARLPIRPVTRRGHHRLNSSIQSVGSAGASDYSSLTDSGPPVSMHNNRRSSYVSKHRRNVSSQSSLGRTDWAAHRRNTSTASSTCSNTSMSQILRPGLGDRMFQLDGGVQLTSITGSPPDDGAKASTSYQRSASWDSLFDMACGKVPHDSLFDASRAMMVDVSLFNDVSAPRDSFISSADESSRTSIGADPFFGPQQQPTNEKFFLRGLRPISTISTDTSSSATDDTFVGATSTNVTESVYELGKCLQGSGEDISNITPLGKKKTRPVGARQMLGSTMARPPKPGRRRPAELIFANVPVDTPGLTSPSASETSSGLSLDTNAASFSFGTRARGHCRQASCAKVNIDATIHEMPSLATLRPNKSSTSPAPSYAFDPQSELTVMGIETREMEEEVDRLNSVRTWVQWEREAVDEFRKAKNVWVDSEESRMAISDWDMPRTTDEIAAFLAQSSQTYKPLEQLPVGRIAHRCKSSLSDFRSICSPYGLPLPKPAPVNKPKMSLTTKYEKKSSTGSKASTTPSAFSFAFFPDDVPEAPSSAPISAPFATGSVPFARETPWSPPPKIAAFKPISPFQLPVLDTFGVRKYLENKTKVNNVKKANEQSERKRVDSKAKRQALGWGRKTDSDGPEMVMNVNKHVKPESESKVSALKHLQLKPLILPAKASARCKNKENVYIEDNSSSFINGPERATNKWRPLKGRGARRSPAKRKQVPLYVGSQPSGLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQU3</accession>
    <name>A0ABR3BQU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase epsilon subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in DNA repair and in chromosomal DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613519.1">
        <property type="nucleotide sequence ID" value="XM_066758117.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990485"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000799">
        <property type="entry name" value="DNA_pol_eps_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="291"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="541" mass="61119" checksum="16A4C2CC521502C1" modified="2025-10-08" version="1">MVNQMRSAIVKVFSTKHSLTLPAPSLHYIEEVLMENEIPEDEWVVGLEFWAKEYLKAEDSSSLVSLQALKKAYENLQLGTTEDTQIPDPSEVNVESHFSVVDSFSMPAMRYDPVRSGFVQSKVPPSVAGQASSRSTFLRERWAIIKEIILRNENFTPPAIGGHDRANYLKLTSIRNLLGRAGQLFLLFGMLARNEEGKLCLEDGEGRVVLDMEDAVPGEGLFTEGCMVLIEGEYTTEETVRVLAMGHPPSERRDIARSLHGHVDFLGCGAVSLKEEQKYNPTVLANTQISFVILSDVWLDHPRTMPALRQMFEGYANTAEYRPMVFILCGNFCQGGWDGEEGLKRYTRGFNSLAELLQSIPLLHSSHFVFVPGPSDPWSSTTLPRPSLPSAFTTRLSNRIPNAKFVSNPCRLKYFGMEIVICREDLMGKMMRNLVVVKEGEEMNMKRYLVQTILDQAHLSPLPISVRPTLWEYDHALRLYPMPSAVVLADKYERYELTYEGCHVFNPGKFVGGIGEDGWEFEWSMYYPATGRSERSVLTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQW7</accession>
    <name>A0ABR3BQW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103649</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613538.1">
        <property type="nucleotide sequence ID" value="XM_066758136.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990505"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="330"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0247577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="549" mass="60381" checksum="5473DE15724D94E7" modified="2025-10-08" version="1">MASHDDYPQSQLRRSYGGAMEQDVGLLAPGPAGYHYDTPYEDEDGPGRDRMMTTSPSIGPWDSASQRSLPYHSQPSFPLPQPRHMPLAGNDTLSSREKHFTDSYNGYKDGEYYHTDKVRPRSTALNGSSAFDTVEMGNVKPVSSYDDDPAKYTLYHDHPSYPYPPLHQGQGEGQEAGYAGFTRPSNLYSMLLFPTGLDRLLSLFNIKAGAYPIEQAIERKKRGLGGQKYPVAAWSLAAAMTAIMVYEMVRNYQAMGTPIAIKPVFNYMIGPSSEVLINIGARFPPCMKNVSALPATFELACLNDTSSSPTTGCTIEQICGHGGFHGETPDQWWRFILPIFLHVGIIHLIINMLVQITASAQVEREMGTIPFLIVYMLGGIYGFVLGGNFTRTGIPSVGASGALFATNACVLVDLVLHWKYEERPKLKACLLVLELGIGFAMGYIPNAVDGLAHLGGWAMGILCGIILYPAITETKRRKYVVWGCRVMAVALIIMAMVMTIKNFYTDDPNKACEWCKYLSCIPTSANDRCTGTGITTTSTSTTKRSWDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQY9</accession>
    <name>A0ABR3BQY9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sorting nexin MVP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103657</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613544.1">
        <property type="nucleotide sequence ID" value="XM_066758142.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990513"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07597">
        <property type="entry name" value="BAR_SNX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06866">
        <property type="entry name" value="PX_SNX8_Mvp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035704">
        <property type="entry name" value="SNX8/Mvp1_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46571">
        <property type="entry name" value="SORTING NEXIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46571:SF1">
        <property type="entry name" value="SORTING NEXIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="226"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="612" mass="67628" checksum="85E02EC7F43FB0AC" modified="2025-10-08" version="1">MFNSPRPMASSYNYTDPLSNSAAAGAVFGELDPWSSAPSPAGSATPARTTASVSGGRNETANGSKEEGLNGLINDPPALYVSLLDQLDANGTGEVSLAAVHRLLNTSKLPAMVVEKIIHLTSRDKSTLTRPEFFCALALVSLAQSSSSPNDVSIEKLSSSLSNLPLPKLKPSDPPSVLSGVAANTTAATGFNAWDGTINKGTTYSADSSTFRSIDPMVNSSENGWWKDKERIVVTLIPEKEGWFLQKYRIESDKRGEGPVARRYSDFVWLMDVLEKRYPFRILPPLPPKRINPSSAFLEARRLALTRLLSFLTAHPVLRTDACLNIFLTSSSFESWRKRTPVSTDEESLSKKLTTAQEMSIPSDLELKLGNLKERLPAMLGHYARLVLMAERSLVRLQVQAAEAARMAMSTQSIGELVPRCCWRNVQGDDAENVGGVARECELCEGVGKGWGDVGNGWVSVGEELEKGVQLLQKHIEALKSQRDLYSSFHALFYRHSKQSLDNVDALRKKVDSRFSKIESLKSAKKPGWEGEVDKLVSQSDRDTAEIQHLLARRVFVRACMWHELSVVFHSMQAAQGTIGWRDFVKDQKERTKRLNSVWQGLEETLESMPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR30</accession>
    <name>A0ABR3BR30_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2-16 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613607.1">
        <property type="nucleotide sequence ID" value="XM_066758205.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990579"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="147" mass="16470" checksum="74FD984BC7CDD095" modified="2025-10-08" version="1">MALKRINKELIDLGRDPPSSCSAGPINDNLFQWQATIMGPADSPYSGGVFFLSLTFPTDYPFKPPKVQFTTKIYHPNINANGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIANTYKTDRARYEATAREWTRKYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR32</accession>
    <name>A0ABR3BR32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP synthase subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613609.1">
        <property type="nucleotide sequence ID" value="XM_066758207.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990581"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7899" checksum="4699A33857F12461" modified="2025-10-08" version="1">MPPLGIKDLTMPAAAFTMAIVLGAHVYSSINQARQEAQFKRAQMLELEYEKKLGRLSGSQKVHPEINDNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR63</accession>
    <name>A0ABR3BR63_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 13">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_103735</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 13">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 13"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613619.1">
        <property type="nucleotide sequence ID" value="XM_066758217.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990591"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 13" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 13" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="16">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="16">
        <location>
            <begin position="157"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="15">
        <location>
            <begin position="307"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="14">
        <location>
            <begin position="596"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="14">
        <location>
            <begin position="658"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0247658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="798" mass="87918" checksum="6BEF52CDE19CA2A6" modified="2025-10-08" version="1">MSCAHLQPSLHSLKPPTTSQQVHREECTLCFDGQDDPQGVLVCLSCFNGACLSSDRQHAHLHYQKTGHPLGMVIKRSRKEIRKRDSSEPPMKKLAISAPKDEEIWDYNTSFVCLACSSAGQEITTQEPKLDEMKSGIMTALSSAQQSEIKAWEEEIVPCEHTLTLQQEPVVVPGNVPSQCSSCDLTSNLWLCLTCGLANCGRQQFGGIGGNGHALKHFHETGHMLGVKLGTITPEGTADIYCYACDDAKVDPELATHLSIFGIEVMGQTKTEKSMTELQLEHNLKFDFSMVGDDGKELEPVFGKGLTGLKNLGNSCYMASVLQTLFSLPAFRRRYTTPEAYNHFQTCPNPLPTSCMECQMLKLGDGLLSGRYSHAAKLPPPTTHFEEQEAPKFQEGIKPTQFKALIGKGHEEFSTMRQQDSEEFLQHLLTRLRDEAKRQGRNGPTEPTEILKFAMEQRLQCGKCKRVGLQVEGVDLASLPVEAVEAGVSEDGKKLYEGVELESCLEQLCAEEPVAEYQCANCKDKTTAYKSTKFKTFPELLVLHMKKFQLVNWLPTKLDIPVSVPDILTLDHLIAQGLQPGEKELEVSSSSPSLPEFNATAMAQLEAMGFPTVRCQKALLATGNSDAETAMGWLFEHMEDPDIDAPIELRGSKAASNEPSQEQIGMIADMGFSHNQARKALRESDGNPERAIEWLFSNPDDPGEDAAPAPAGSAEPLYGGSCSLPAKYRLKAFISHKGPSVHSGHYVATIRQPQAGIEGEREAEEEWVLYNDEKVVRAASGGGEEMRGLAYLYVYERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR68</accession>
    <name>A0ABR3BR68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613360.1">
        <property type="nucleotide sequence ID" value="XM_066758912.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991291"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="9">
        <location>
            <begin position="791"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="639"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="731"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0247399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1038" mass="114494" checksum="3E9966B2A5405775" modified="2025-10-08" version="1">MATQMRGLTQYISDLRACRVRELEEKRINREMAHIRQKFKDGNLDGYQKKKYLAKVVFTYILGYKVDVGHMEAINLISSQKYSEKQIGYLALTLLMHENSDLARLVINSLRKDLEDQNEVNNCLALHAIATLGGKEMAESLAESVYRSMISATSSTFVKKKAALTLLRLYRKHPSVMPIKEWAARIVSMMGDRDPGVVLTVTALVTTMAQAEIEAFSGSYQKAVDILDRIVFEGHYPAEYIYYKVPNPWLQIKLLRLLQYYPPPDNPQVVEMVNAIIQAIIDSSQDTPRNIQHNNAQNAVLFESINLAIHIDPSSDVVRNASVLLGRFILAKETNVRYLGLDAMAHLAATSNSLEAVKKHQNIIIQGLKDRDISVRRRALDLLYSMCDTSNAKVVVGELVRYLQVADYNLREDMVLKIAILTERFATEYEWYVDTILQLIAAAGDHVGAEVWYRVVQLVVNNEGVQDYAVRAVYKHLQATACHENMIRVGGYIMGEFGHLIANDPGSSPIEQFQTLHSKVNLCTAPTRALLLSTYIKWVNLFPEIKEHLINIFERYTHVLDAELQQRACEYLALARRPESDGLLATICDEMPVFPERESALLSRLHRKGEKAQDKRTWVIGGKEENTAREAERFKAFRRGTGDSGGILSGSPAPASAAPSPVPETSSTPQRHASAGTETMMGIASSGPSEDILSSLADLELTGSHVQNQPLLTSAPTGAYSQELAGLHIQPTGAGGAPLPGGQVNGSNGSNGINGSNGDAKGLAYHATLGGVNPALLAPLTVADGVEKWFERLSFSNEGVLYEDTFIQIGVKAEYHGHLGRIALFFGNKADQPFTSFSALIDNPSPSAINIHFHDAPVGEISAKAQMQEMIHVECREVFFHEGGTPLLRLSFLVGEERKILVLKLPVFLSKFAEGVHLESGPFFERWKVIGGPPREAQLIFPIKLTANGTVDIGKNQRIITGNKLSVLPDIDHKPENIVFAGVLHMSSAGKVGILGRMEPNKDAKLCRLTVRSTNEHVSAEILSLTSKPLNTDVAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRH6</accession>
    <name>A0ABR3BRH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_104605</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612558.1">
        <property type="nucleotide sequence ID" value="XM_066759071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991461"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0245474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="361" mass="38951" checksum="71D93E88A0276580" modified="2025-10-08" version="1">MVAGTVHVGQHLAGHPSVHLFGHEIVLDVSIPALILSTVGAAFLLRYTLSIFRLFLELTVLPGKDIKSFQSRKGETWAVVTGCTSGIGLEFARQLAAKKFNVILVGRRQSALTDLSKEIESKYGVQTKSVTVDVSTPGSARDDALAELELLAQNLDVGVLINNVGASHQMPVAFHETERSEMSRIIETNISWTYLVTRSILPSMVARSKQKGGPKSLVITIGSLSGRIPSPLLASYSGTKAALATWTKALAEEVKPQGVIVELVQAAFVVSNMSKIRKPSPFVPTPAPFVRSTLNSIGLPRGAQGRPHERTPFWSHAILDYAVGFAGYVSEMAGIKVILGMHNDIRKRALKKAARDAKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRR7</accession>
    <name>A0ABR3BRR7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613837.1">
        <property type="nucleotide sequence ID" value="XM_066758435.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990810"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="84"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="421"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="464" mass="52758" checksum="94A78B7CBFF739FC" modified="2025-10-08" version="1">MADSYYENQTHSPSPNGEQYSNGEAYPSARIASPNGGGVSPNGYPADGGVESTPAVVAPARKKLSSWVGFSNLPNQVHRRSVRRGFQFVTMVVGESGLGKSTLINTLFETKLYQPKQIPTPGADRGKTVQIESISADIEENGVRLKLTVVDTPGFGDFVNNEESWKPIVDNIEARFDAFLEQENRVNRSKLLDNRVHACLYFIQPTGHSLKAIDIEFMRRLHNKVNLIPIIAKADTLTDDEIIAFKQRILADIAHYGIQIFQPFQYENDDEETIQEIEEITSKVPFAVVGADSTVQSPDGRQVRGRSYPWGVIEVDNEDHCDFVKLRQMLVRTHMEELRQHTNDVLYENYRTEKLRAMGVQQDESVFKETNPAAKQAEERALHEAKLAKMEAEMKIVFQQKVQEKEQKLKQSEEELYARHREMKDALEKQKQDLEDKRRRIESGRPLTPEKGSIQQKKRFGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRT7</accession>
    <name>A0ABR3BRT7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103701</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613585.1">
        <property type="nucleotide sequence ID" value="XM_066758183.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990557"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="552"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="85"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0247624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="686" mass="77322" checksum="76879C50E40FCED5" modified="2025-10-08" version="1">MPAWPMRHPTKHTRFLSPLFCVLAFLFSCAIYQSFRADLKQSGAWGCEMSWMSPSYRRLEWTEFVSTKYALYLYREQGWDSEDTLSGHPVLFIPGNAGSYQQVRSVASSTSKQFYEQVKAGEGSMQTGKKIDFFTADLKEEFSAFHARTLREQAVFIQHCIRRILQEYTHLPEEKRPTQITLLAHSMGGVIARLAMDPATSISVDIIVTLSTPHILPPLALERDMDSIYSLITWRRQHISTHPPLISICGGISDTQVVSDSCALPSWQGQTGNNSDFAVFTTGIPGVWTAVEHQAIVWCHQIRWRIARMLLDMSINTNTAAKLVIARKWLLDDQEDETFNGPHKGRLHDYSVSSPNMTFIRLQQPSKAFVAQQCNGLEPCRAVTSVMRLLPFPRDSSDPFPLPGEGIKPNEVMLAAEVRLSSTSTVVKTSASKYGQTIAGSREYHLVKGNSWKVDSLLPTLTTHHLFHFENACLSSLVTYSLDITLGHCEVITLHQANPYIYTLILRRDPSYLTKAELAFIWRYFNRPHVLNIIRHLNGHERFDDKAKSKHGWLGVVMTGAIAVLVNQLIPHQLIFLICVILLWLSAARSKHLNSQYLAIWSRNIWTGSAAIINTDSNFYYAIPPVLLVKLASCGGTIQKRHVYLQACRIALLILIVASFSVGGRWTWILPPIANAVLILFLASIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRX1</accession>
    <name>A0ABR3BRX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613872.1">
        <property type="nucleotide sequence ID" value="XM_066758470.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990845"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF105">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="4"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="511" mass="56644" checksum="F979B05A314DE9A9" modified="2025-10-08" version="1">MSGNQKQPIHIIVNPAAGQGKGPAFLEEYIIPILNHFRQSYRVYTTTAPLHAGEIGRSIMDSRPRKFAEGEEKDEPIVVIAIGGDGTTHELIEGVTVGHQAGKEEHGWGRWELIVLPFGTANALYYSLFPPADPLPDTSILSSLPYRPSLEVTAKILPLVSFLTRSTSPLPLPITLTTLLPPPSPRHGELPETSRNIKPIPTHVVLSTSLHAAILESSEKLRETHPGNERFRIAAQESMSIFFDATASLFASDSKFGRGRRVELGVEQWDPRVGSWVEPFTEHRVIVDEDGKGKKGIELQGPFAYFTSTATVSRFEPAFVISPLTSLRPSSPSEQRQQDGDRDASKKNKNEYIYIIVLRPLRDPYVLSASSPTSFSEKPGRSGRAGRRERWAKRAQEVLGKAYHDGAHIDLTYPLYAMEKEGSVSGEGEEEEESWEAEVKGRGEPVVELYRCAAFSWEPIPTTQTNWTKGKGNERARLVCADGALHWIPEEGKAEVELMVPSEKGGFYVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS62</accession>
    <name>A0ABR3BS62_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613984.1">
        <property type="nucleotide sequence ID" value="XM_066757600.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989955"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="156" mass="17551" checksum="C8C94B6BA58C1F68" modified="2025-10-08" version="1">MPGQRLATKRLMKELGDIESKGTPPGISLLSADSMEEWIFTITVLGDETIYKGEQFALRIKFEDRYPIEVPQVTFVVNDIWQAPVHPHIYSNGHICASILGNDWSPVLNAVSICITMQSMLASNKSKVRPEGDQRYVRNAPANPKLTSWKYDDDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS67</accession>
    <name>A0ABR3BS67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613987.1">
        <property type="nucleotide sequence ID" value="XM_066757603.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989958"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="94"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="94"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0249800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="240" mass="26433" checksum="B388C8295B2486D9" modified="2025-10-08" version="1">MSAPSWEEMEAKRIEMIQSLREVSSAMTRCVQVIEEYTSLSPVHLSKPDLLQPLTAGGPLAVALASGLADAGVGSSGKKERKKKEKKIRDPNAPKRPPSAYILFQNEVRDDIRTSNPGMPYKDVLQIISQRWKELPDSEKKIFEDAYAAAHNNFRAEEEAYAKKDVVEVDPALMESSDDSSDDDSSQGESTPAAPIPAPTLAAAEKHKKDKKRKTKEEEAAVNAVLGEGKDKKKKKKSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSB9</accession>
    <name>A0ABR3BSB9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_103650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613539.1">
        <property type="nucleotide sequence ID" value="XM_066758137.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990506"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="9">
        <location>
            <begin position="31"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="202"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0247578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="586" mass="65002" checksum="2B7FF096E184E055" modified="2025-10-08" version="1">MLFNGLLEAVFSSLPFLAPSYRLSAKPDINLVPLPARYTVGDGSTPLCLSTNFSIQSASSSSAIFPSDLQEAIASTGHRLRNTRATYLSTTEGLEFFTDSSGAIRSCPYYLDTLFIDLTVYNGTDIHSETIAPVEERAELEAYTLDLPLKGKAMIASRGALGAFRGLTTFEGLFYSLETEVQGSKRVHAPLAPYHIKDKPSFGWRAVLLDSSRHYFSVPAILKVLDTMAMVKLNVFHWHITDSNSWPLDLDSYPELAVKGAYSRSERYSQKEVQMIIDYAAHRGIDTLLEIDIPGHTASIAPSHPSFAACFESTPFKHFAHQPPAGQLRFADHEVTEWTAQLLQEVSSLSKGRYFSTGGDEINVNCMLEDLPTTSALKARGWTLDDALDHFTKKTHAPLRHAGKTLVVWQEMVLNHGKMSSLTNDTIVDIWVNSADARKVLDQGYRIVHASADYFYLDCGQGGWIGEEGGGNSWCDPMKSWARMYSFDPFKDVKDEERHLILGGQTSLWTEQTDEMNLEPTLWPRAAALAEVFWSGPGPDGRPRSANKALSRMHDIRYRMVGRGVRAAPLQPHWCALRPGACVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSG6</accession>
    <name>A0ABR3BSG6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613584.1">
        <property type="nucleotide sequence ID" value="XM_066758182.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990556"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="288" mass="32366" checksum="5ACD735679997AE7" modified="2025-10-08" version="1">MGSIRKRTKKKPIASSSSASLTSSVSHKVTRSTITAFHVLLRKKANIAKKVQHAATDSEKFLRQKELDAINNNISELGGLDAYQRASQLGQSKDRGGDSSRILVSWLLEMGIKKDGPLKMLEIGALRPDNYASEKWLKNTPIDLRSQHPSILEQDFFLRPLPSSEDESFDLISCSLVLNFVDDPARRGKMLQLIHEHLRPSSESLLFLVLPLPCVNNSRYLTLPVLAEIMEAIGFILVKERCRTGGKVGYWLWRWKNKSGFGKDRGLLQRKVQQQSGAKMNNFAIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSL4</accession>
    <name>A0ABR3BSL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PRKR-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614135.1">
        <property type="nucleotide sequence ID" value="XM_066757751.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990107"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23528" checksum="DB28A8D958D2D9D9" modified="2025-10-08" version="1">MSSPRSSAGSPADANVASSTRPRNTVLDMQRRQLEKLLANPDKEVSLPTGPQEKTLRAPREMMKNVQGSSAGAGSGEFHVYKQSRRREYERIRLMTEKTKAEEEHAEFLKRQAERDAIAEAKTAKNRAKRQKRKQGRKGGADAAEGGATYTGDGGVAKRKLEGGAKVLFKMPGEEASDSEEDIGPVAPAVEEQKPEVVEPQRVAEEARISIVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSY6</accession>
    <name>A0ABR3BSY6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613410.1">
        <property type="nucleotide sequence ID" value="XM_066758962.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991344"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="364" mass="40476" checksum="DAB80DC0AD370F51" modified="2025-10-08" version="1">MAQPEYPELDPEELEEEEIYESETASSTQTSTLTWINWYTSLTGHDYFCEVHEEFIEDDFNLTGLQSMVPFWKEALDMVLDVEPEEDSSKIPDVSIVESSAELLYGMVHQRFILTKAGLSSMVEKYDAGHFGGCPRVFCNATPVLPCGRSDMPGIDTVKLYCPNCGDIYTPPSSKYQNVDGAFFGTSFAPLFFQTYPELHSVPFCPSSSSSVAAGTNTSSTRPSPTPSTTPVGGATYTNPNPHGGQRPALGRVYQPKIYGFKVSERARSGPRMKWLRERPEKAEELDQVDWKGRWKNEGGVYGAGNGNGKGGDEDEEMEGNREVKKGKLFDDEDEPEDDDEEEEEEELGKVVPEASTATFPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT08</accession>
    <name>A0ABR3BT08_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein EFR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613963.1">
        <property type="nucleotide sequence ID" value="XM_066757579.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989934"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="661"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1106" mass="119708" checksum="57F300B159ABCAC1" modified="2025-10-08" version="1">MGCIPCRTLQPEVIHLKACYPPPKALLTAGPEYRPLSQDLSKLTYFATNKPSKLAKIGEELEKRVTLESARASSGNHKYRASLLISLAILRALLTECKRDIALFARSTLRVIDKSLDVRVYQHGGIDLEVVGRAAAAFIAYTTYTDGSAVGVDDILTKTYFDILRKFGSMATVSLLDSSEKPDMEQQNRTRLIALAGLNGAATSDTIFASTRDFPRQIDLIIPPLLVNIFEGQISELKLETAKIGMDASPSPYFTEFAAKGPIAQRKAPSLHAHIPGEKGPTSADVISAALRSLHSLLQQCNVTQASQIIDRLVMFLDKHGWQYAERDCFVAEQVTAWIPLQYRFIVPTRLVEVLMGLQDAPSTPKHTSTLAMVTTILNSTTSLVGLGVTDLLQNLISLIIRRLHFDLCDALLPPLVQCISSLGTHIYYADQINDIVEELALRIAEIPSSDSARSEIIRILTCCISGVMIITDAADNDAESKQGNNVSQPTPSTPSSPTPPNKGKSPAPAESPFLTPLFEYPRSQAHRSSRRNPIFSEVWQETLPLLCEADYAVRSTYARALILFLETEMQRGPTPSATPDKQNVQNRGKEKHFSANMGTYRFCHALNATVYSLMMSSCLGLGDGDGIPTGVPITATASPELHTAANTNPTTSVVTVKDSDSPVALAPDSGRPSPASGGSGSEGATPNREKGVSFKVTAPSTGETPAQAQSGSGANTPPKRNSRSHRPSLPFNRLQSYTHLSSFDNVATPLDFAAALRILDAMHTVVPVAALVTGTPMLLALDRDAGNELVRRPGDGRAGAWVLERKRAIRELVCLIWRRIGDRWGVAEIDELANKALASLPEPYLIPPYPAPASPLVFLSLPEEPVSFVQHTLEGESSSAAKPLLDQDTLLNVLVKSRTVQQATRMDEAGLMKMFNGNWSVERAIKDSVERFSSANIQPDDDSHYNAASALLMSMNNASYQSVNGQRYSRTVDVTDLRDALGGRVDTVSTSGAPSVASFDDSFHSQSAPRSSSQARRMNKEADVKEVLKDIFRDKKKGTKAPKGFVINRVKGGREGEGVRTSTGDENSLGMSGMTQDEGAAGHDVVRGPSLDLSLGRPIDMPSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT91</accession>
    <name>A0ABR3BT91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614361.1">
        <property type="nucleotide sequence ID" value="XM_066757977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990338"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="290"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="565" mass="62274" checksum="7777EB5FCD81CB62" modified="2025-10-08" version="1">MASDRSYVDVLASIDPAQFDWSAYEATYKGRALITRYTHLVNTCVAHPSPPASELAKTALLKLIPLVKSSTWDINTYLWAVSVLFTIVHPGKAWKVSEEMEMDREEDDEGGITKITSRGIPPGEGKEEDGFPDERWITETRDTVAKEVSRLDVELRGYMSNLIKESIRLTQLAFAELAFKVGKVREALNSYAATREYSSTPQHHVDLGVGVVETCLAFNYPAPLSGHIAKLEATLDRLHPPPHAQSKQQAGLSTTASDLRERQAEESRSQAVRRSVMVRAKVGKGLISASQKDWARAGRELGWIEQDEGGLGDWEGKAISTSDLALLSAFYILASSDRGRIRRALLDRATFKSQLDDSQGWIIDLVGAYVDANYGQVMSLLQYSEPILLLNPFLSSCTRSIISCIQTRSIIQYVQPFSTIRIQTMTQAFRMEEDKMLDVVEKLIGDGDVGGKIDLIDNILVMDTLDPRAEMFEKALKAGQKSAELAQASLLRMKLTEAGVMVNPHAESINSEISWKQQQQPLGPEATATTTTTALQVPETAMAEDHSAEDVVMHASGEPNGESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTB1</accession>
    <name>A0ABR3BTB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614378.1">
        <property type="nucleotide sequence ID" value="XM_066757994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990355"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="52520" checksum="F0388F9C62A4DE24" modified="2025-10-08" version="1">MTRPHAHSTSASQPYQPKPPRLLHRSPSEPVHVNGPLAGLNGVNGVNGENGALTSPSQQIYVLTADGSRLFLLDPTRPNGEEPPPYASFPIQHIPDSDAEADAEADVEGNRDVGGGGDTLAPTSSRLLTPGFIPTSNSTVVEPSRRHRARTLSALSAERSRPRTSTTTSRPDNRRARTGLLTATATPGPPYGRGTAVSPADERTPLLAVHVGDGVAEADEAVEGQGDGSLGRRNGMRRGWWRGVCCGELEKGEQVGTWTDGWKRFWRPVGKKEYWASVFHLIFLNFPLALLVWPPLLVGTLAGTALLITLPIGAAVWWITLFIARSAARLEAIMQTYYHPLPPSKLPPYHPIFHIPLAPSPLPTPLHSPTSSPSRPHSHLHSRHSANSNQSLHDEENPTTTTPTQQWDKRFTKCSYAMFLDHYSYSSLSYFLLIKPVITLFSTIVIVVVLLLGGATVVGLPMALRAVKRWGKWQAEVAMENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTB6</accession>
    <name>A0ABR3BTB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA repair protein Swi5/Sae3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614389.1">
        <property type="nucleotide sequence ID" value="XM_066758005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990366"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11212" checksum="C4116BDFCB860F36" modified="2025-10-08" version="1">MSTPTPTPTSMKGNGNKTPFTVHNSILHDQKLKALRAEADALRLQLADKDPNAIVQEHIQLLHTYNEVKDGTQALIGRYALMTNRTIKEIHQELELPLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTE3</accession>
    <name>A0ABR3BTE3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102398</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614412.1">
        <property type="nucleotide sequence ID" value="XM_066756943.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989255"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="626"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="417"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1225" mass="133553" checksum="0C0353B84961A450" modified="2025-10-08" version="1">MPPKNKGKKGGKKDFDDDEFWEKKEAALEQSQATLQTDEAPKKGKKADNSLFDLLDDGGAVSDEEGGGLMATIAANAAKKDKKKKKKASKFADLDDEADEVEPSSAVDTKPNLDDEWPEEDVKPKKGKKGKKEKKRDVEEDEELDEVPAPADEQSEPSTAVNLDDEWPEEHVKPKKGKKGKKGKKVEEEEEDIDVILEKAAAERKAQEASAAPAKVEPEPEAEDAMDEGPKILSKAQKEKLKKEKEKAKKKAQAAAKKAHAPPTESPAEPAEIAEAEDDEGDEEGAAGGDKKKKKKKKAAAKPAEPAPSAKGKKIPAHIAAMQAAMEEKRRLEEEAKKAEEERLRRIEEEEARIAAEEAAEAEAKAAKKAKEKEKLAKAKAEGKLLTPAQKRERAAAEARKQAMLAAGMVVAGLQEGGAAEKKKKPVYGNKKKQQQQQQQKPKETTAPAAPAPEPEAPKAEEKEEESADDWDKSDNEVEKATAAVEKLKVEESEDDWDKSDEEPALEPVKASAPAAKEAPASAAKKVVEKPAGKAAAPAAPTQTQPASKAAPVPAKANGKPTPAAAEESSSEEEESSSEEESSDEESDEDSDEDSDDELAARKARALQKIQERREAAQAAKSSDDLRSPICCILGHVDTGKTKLLDKIRQTSVQEGEAGGITQQIGATFFPRSAIEEKTEVVNKDHAYKVQIPGLLIIDTPGHESFTNLRSRGSSLCNIAILVVDITHGLEPQTIESLNLLRQGRTPFIVALNKIDRMYGWEAKPNAGFRETLNAQSKSVKSEFDDRVAKTKLAFAEQGLNAEIFDENKNLGRNISLVPTSAVTGEGIPDMLMLLVKLTQERMNANLMYISELECTILEVKVIEGLGTTIDVVLSNGVMREGDKIVLCGTDGPIVTQVRALLTPQPMREMRIKGQYIHHKEVKAALGVKISAPGLEKAIAGARLYVAQDDDEVEAFKDMAMDDLTSLARFVTKSGKGVWVQASTLGSLEALLTFLDQMKIPVFNFGIGPVHKSTIVKAGTMLDKAPEYAVILAFDVQIEKEAQELAQKAGMKIFSAMIIYHLFDAFTKYMSEVQEAKRKEAAPNAVWPVRLKILKAFAHRDPIILGCDIIEGTMRIGTPMGVVKIDKETGKREIVSLGKITSIEINHKPFEIVKRSQIGAGAAVKIERAPHQPAKLYGRHFDEKDEVVSLISRQSIDTLKANFRDQVELSDWAMIKKMKVEQGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTF5</accession>
    <name>A0ABR3BTF5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAA35-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614113.1">
        <property type="nucleotide sequence ID" value="XM_066757729.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990085"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="1">
        <location>
            <begin position="45"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="531" mass="61198" checksum="D7D6762AC1A2A595" modified="2025-10-08" version="1">MQDITQWFIKECDGLLWGELVKPSALTMMDAMKAIQPLKYHGIEEQHSASLFTLILRTYLLLYCKTIDLVYTELSKGNIIEGEDCWLDHYGLPIKVNDDVEAIIEFANETLVWLENVKTKPLDGFGDQMINRLVFRRVSDMIFFEAHKQNYLRYLDCATSVDISLEQTLLVMQMVAQDTCPSAIQPSEITRLGFDPKVPSYLRQSMPLPEFRQPTFKQSWECMMNMIEELLHVERLMATGDWIEWKRLPIHRSLIQSRFTAFCYDSHQGNRNIDRLAREAILYECGDRNEVVTVLGTLDGMADAPNMQQLKTWRALIANDILMDLIVPLHNPPRQRRNLISLSTQLQHRTMTGNRLATQYGFSPIVTSVLEIFRLDCLLEAALSAIGLNLIHFSEEREVWWWISEIATTRASAPVASSSFKAIWAQTWAYIASAMQNRRQLDRKQGSCGLKEVAKLFREARESLDGLLLQQPRNLRAASRIVSLQQALEHNIRLIDKLGTEQNLMWDLKTNDREGRWIMLLLATNTASLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTF9</accession>
    <name>A0ABR3BTF9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614423.1">
        <property type="nucleotide sequence ID" value="XM_066756954.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989266"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="19"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="338" mass="36435" checksum="2B35325DE4E850C7" modified="2025-10-08" version="1">MSSFQIPKTMKAIQVDAAGGPEVNVLREIPVPTPKPDEVLIKVQYTGLNYIDTYFRSGLYPKEFPYTVGQDAVGTLVQGPSSSDIRFDIPLGTTVFTPAGSSFAEYLVAPASRVGVIPEGVDHKDGVSWSTVGLTALALAKESYPVKKGDWVLIRAAAGGVGLVLTQIVKYFGGHVIGTVSSQDKAELVKSYGADLVLLSTDPSEDNVKKILEVTNGGVHGVYDGVGKDTWEEDFQVVRRKGTIVTFGNASGAVPPFAPLKLTPKALKVTRPTVWSIVTTPEEFKEYTTELADIVKKAGLKFEVHKVYELRAEDVIQAQKDITSRGTKGKLLVHVADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTG4</accession>
    <name>A0ABR3BTG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613914.1">
        <property type="nucleotide sequence ID" value="XM_066757530.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989884"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39175">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39175:SF1">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0249727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16505" checksum="FE5F4B11C6BC4629" modified="2025-10-08" version="1">MTASYTPIAIQHVNLAIPKGTLELAQEFYGDVIGFKNDQVPQLQRDTLLWFRVGDGPQQIHVSFEKGHSEAGPALSGPSPISSRHPCFSLPSQEALSALQERIYQHHIKGVPASAQECDKPGGENSGSKGVEFPTRFFARDFAGNRLEFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTS2</accession>
    <name>A0ABR3BTS2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614248.1">
        <property type="nucleotide sequence ID" value="XM_066757864.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990222"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="97" mass="9957" checksum="9603D3F0D3E31878" modified="2025-10-08" version="1">MAAEAMIGWMADRWNLPAPTTTGSSASEGSAGTSTSYSSSSDSPSETDSSSLSNDNGSSEKTSSRESTSPKNTPPAGINRFFSQQMQNVADALAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTS3</accession>
    <name>A0ABR3BTS3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614539.1">
        <property type="nucleotide sequence ID" value="XM_066757070.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989382"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="355"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="457" mass="52097" checksum="3B97702D8C548844" modified="2025-10-08" version="1">MAQNDSFQAHAQKFDVFAEIVQTRLDTIEFKCDDSLNRKEFGIMGSLGVITQEVNALRDDFLSLFSTRACSISRQRGRSHRSADLPSEAAGRHSPAQFINGHRQSSMVSDCDSGYGGGIVERAIARELKRLGSAPVLAEGETTIYFNPRKRWSRRKVDVLDIDEESDLQSDTASSGVYPMSTSPERRWTNDDEESEEEGENNEEGMESEGVEETELSELIPEKGEGHIHERGPFVKRDKVLAASDGRNIGGQKWPKLGLDCTEGRMKVIDCSACNGRVHWACAGLDPAVSMLKKAWYCPSCTLLIKDLEPAVARRMKEREELPRTQDRERCLRPDCIHHQPIDMTFAEAEDDNLYYMSRIVGKRYTKDRPRTLQYLVQWNEWDDYDCTWEPLSNIPAMDLPGYKSLFYKQARNENLDLSNKKTAILSQFSQYFETDGSYNVKLLKELGVADKDWWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTV5</accession>
    <name>A0ABR3BTV5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Nucleus and/or cytoplasm.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614567.1">
        <property type="nucleotide sequence ID" value="XM_066757098.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989410"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="6">
        <location>
            <begin position="266"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="552"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="898"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1027"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="900"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="934"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1030"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1066" mass="117704" checksum="E363C55F5E7C09C9" modified="2025-10-08" version="1">MSEENPTDIVHQLQSIDSIEQGLADTAAAVVDAASQSHPPQQHAAQDQKFQSTLLDNAESIESVLESAIPPAPGSSSTAGASDAIGDNSFTTSGPAPFPDTVVAPSAANDEIGDVIVVETETPTTTNVVEAVVNPENDGNIPIESTEQSSEQPKEQPTEQPTEQFTEQPTEQPAVETPLAPQSTPAAPATSAVENVSTTLEDTQPEQIVQTPVPIAHTEAPMHVVDMKTEEKPLIEHATWIPPQEIRSDVFLPEGLTEYSPSVSQNSELIKSWRADPSNPTLLLSLFNWAVQKTEVEDARAWYRVLAVDNPTATQPLLALINLELALSNFAEVETIFASTLKGSAGITTAADVSIWTAYLHYIRRQNPLTEGSANAADVRSTITEAYEFALRECGFDRESGDIWDEYIKFVATGPATNQWETQAKSDNLRKIYQRAVCIPLNNIEALWKSYDNFESSLNKLTAKKYLAEKSPAYMTARTALRELRALSDPIPKPILPPYPTFTEQDRQIVGVWKAYLRWEEGNPLVIENHTMLQSRIGYALRKCLGEMRHFAELWHYVASYYSKLGKQDEAAEILEAGVNACPKSFLLTFAYAELQEERKAFPTCHSLYTTLISKLNPEVDELRQNVAREVEIARGPPIPGSEKAAVAAAVGDSIDVDGNDISDIQRLVEEREQRGELVAQRRGKDVEELMIGISVVWIMYMRFARRAEGIKAARGVFGKARKSPHLTWHVFEASALMEYHTNKDAAVAIRIFELGLKQFSEDVDYVIKYLQFLLSINDDNNARALFERSAVRITGDKARPLWDAWARYEYTYGDLSAVHKLEARISEVFPEDAPLKRFAQRWSYNGIDQIAIRDLGFNRARMGVPVLPASTIAPTLSPPTASIIAPVVAPAPVQLPQESYKRPAPEDITPRQPSSTEFSRSPKRHRAQSPPRRYAERDDRPPAGRYRDSLPPVKAPSSIPPAHLGAGSTFATPPSGGYGGDKDRSGLEKPLAWFMAQLPNARSFDGPIFRPDDIMKLFGGLSLSGAGMPPAPPISRGPAQPPMQSRGYYEPERDRRYGGNRGGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTV6</accession>
    <name>A0ABR3BTV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">IQ domain-containing GTPase activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614569.1">
        <property type="nucleotide sequence ID" value="XM_066757100.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989412"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="686"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="1398"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="839"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1283"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2055" mass="228825" checksum="94BCB0808088FA15" modified="2025-10-08" version="1">MSNGPQNSPPRGASGLGRSSSIFSYQTRLLARNNSNTSLSNGRQTSTNHSSITASPAYASLASIGGKGALADSPPSTPIRRAVAKMVIDNSPSPTSTPAARTVSKHVRAAKSVDLVRNQWEAKIAGAQDGGTTRTMQKGGRAISVIPRTAPMPSEAQLPTPSSIPSTESTAQAATQVEVSLAKVPTSFDSEKDESSRFSSSYMAQRVAKRATVYGASEFDSMRIPSTVSKASAPVSPIERVTSPSIASTVQLLSPNTTGEGPAPTVRGQSMEERLAIAKANALKRRQAREQAKAAVTHTQPATQPTVEKGIMSGQQVALDDESGIAKKMPSQDKVTNSNMVPSEMTNRKIEANASHMIKPMADVNVAKQPSPSIPLASKVAASPFRDPFTPSSRPTELPTPAPSTVSDSNPLYSRSSLRSIVTPPLASASTSRYVPSDLSSSVASAVPSESSAPSSGGGKYGSISRTDRRRLGRHLPRIASGEKGWEDDEASKGNCNPSEGRRVPSTLGKHSTISADSEEENKPPGPKIGKKIDGHVTTNFTPKASIARATRPPDILAPSANENQPYPQASRVPSTPSKRRSQFMPFTPKSTITDPINPKSPRPELTGEEMKGLMNAVGSLPARGDQKDEEDGVTGMSNRLRLTKSRLPPSASSASVAPIPLPSKRLIQTNWMDKHRHALGSYEYLCHVGEAQQWIEGCLEEELPFGVTEMEEGLKNGVVLAKLARVYEGEEVVKKIWTETKHRYKQSDNINYFLNFVRNVGMPETFIFELTDLYNKKNIPKVIFCIHVLSHLLARLGRAERIGNLVGQFEFTNEQIAAAQKDLQGIAMPNFGDAGKSLAKEASWAPEEPEETEDEKRDRLLQECEDSIVGLQRHLQGHLARMRSSRIQAQLELAEPITRRLQARARGALCRRALSAELEKRKQLHSMAQSIQAAVRGQTVRKGWEKRVREVRNLEVVGLQAHLKGLLARTKRKTVEKGLGNTMKGVTGLQAHCRGCLVRRGRRAYKTSLEEPQTVQSISSFQALLRGRLHRQTAATQQRKIVSQTATFTSLQSHLRGAIVRRNIRAQGQKMDDATNYVVAVQAIARGVLTRNKKRIFTRELQQSTSSTVSFQAFARAHIAKQSHKSMQKALAKVEVAGSVGGLQAFLRTKLAKKQTTEQKKKLEFVQPDVIGFQAMARGYLAREEYHFWRNYLHDGKTIGALVFLQSLMRGFIARRRHYIRTSFIHRNVDKIVKIQALWRGRQQRVSYEKLITGIDVDVPTIQSYMHLLDDTESDFADQVRIEALRGQVVDLIRENQTLETEVKDLDTKIALIINNQMTFQELARAKRRTETATYHAPNNDPFSSGVHLDRTNQRKLELYEQLFFMLQTKPEYISRLLRVLSIDDESAEKERRLVEGVTMILFAFGHERREEYLFHKLLQLAVHEEILRAPTLQDLVHSRFPIIPVTAQYIKTSLTPYIHNVIAPHVMRIVDAPELDLCTDPVRLYIGAINAEETQTGMPSALPRDRNADQILQEHAITRALFIRNLQELRNLTDFLLTDLLQSHDKLPYTIRLMAREALLALQRKFPEAMDDDLVPVVARTVILPFLLPAIVAPEQFGMAPDGVGAVERRNLSELANLLTHVAGQGYTDTPDQRLICTPLEAFITAMAFPFREWLLDVADVEHAEGHFHAHELFESTIEAKPIKITRKDIYGMLSALIQHVDVLTHGSKKDPIVPILEELEGPPIDYDKSKNQVNLRLTNRLAGPTPGDPKAGAKADWIQAKRHVLAVLRVQTGKTLFDVLVSRPEDIHEQLWIQEVHRDIALENARKARHGLPPAHVEAEYQIESIRSLPFHEVKSRAIEFCMKLERSGRLSREDNLQGLLVSIASDIRQKHHLRKLRKDNLAGMIKAHEDMSKKKGKFEGRVQAYHDYIDGAMAELQAKGKKKPLFMSKQYRHQMSQKKQGKQAKFGSYKYTAADLYGKRILLSVNQFSPRQFDKLFIVISSNEVGVFNLELSYPSSTSLPGSSLRQDEVRMEDLLGAQYEDKERLDMFEGQAAFNLNMLIHQINKKFYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU00</accession>
    <name>A0ABR3BU00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614094.1">
        <property type="nucleotide sequence ID" value="XM_066757710.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990066"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="216"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0249907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="451" mass="48294" checksum="A6DD3DD84A7FBA0F" modified="2025-10-08" version="1">MPKSSLASLPTDVQSHVNQAIDSLRDLIPPDPSFVSEDIKDVIFKTVDELNDDMRKLSLAIHDNPELGFKEFEARKNLVAALKKLGFDISNPSKLETAFVATYTRGKGGRTFAFNAEFDALPQIGHACGHNLIAIVAVVSAAALKAAMEACDISGTVKVIGSPAEEDGGGKIHLLKQGIYDDIDACGMAHPLGGMGPSEFSGSCPIGGPATLSRSGLEIEFHGRGAHAGSAPWMGVNALDAAVQGYTAVSMLRQQLEPTMRVHGIILGSENWVTNIIPNYSKVSFGTRALDTKQCVDLREKVITCFKSAAESTGCSCKIKAPDDEVYAETRNNEKLAHAYQIFMARAFGDKIQLEGVNTASTDFGNVCYKLPGFHPMFDIPSEEGSSNHTPGFADAARTPEAHNCAIKVAKGLAVIAAKFITDDNFANETKQAFEKLKEEVGNSEGQSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUP6</accession>
    <name>A0ABR3BUP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_102838</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614842.1">
        <property type="nucleotide sequence ID" value="XM_066757373.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989694"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="13">
        <location>
            <begin position="453"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0250655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="762" mass="83890" checksum="7C00539E8DE852A7" modified="2025-10-08" version="1">MAAPSEATIQLSPEAEAQYERITRSLQEVTSGDVIRKVLSEGKVVKAYWGTAPTGRPHIAYCVPLLKIADFLTAGVHVKVLLADVLFTVLGVPIDKLEFITGSSYQLKPDYTLDMYRFHALTSTREAEHAGADVVKESESPLMSSLLYPGLQALDEQYLDVDFQFGGVDQRKIFMYAATFLPKLGYSKRAHLMNAMVPGLSGGKMSASDPKSKIDFLDTAADIKNKIKAALCPPGEIENNGVIAFIKTVLIPIQALRIEQAEQRGEKAPVGEGSFVKPGAPEGAVFSISRPEKFGGDIHVKSYEELEKAYIAGDIHPGDLKTGVQEALIQFLSPIRKLFDEDKEWQEIERMAYPSSSVAPSAEEPKKAKKKDVRSKPPTEEERAALRAAKEKEKAAKIAAKAVNEGTAPPVPPIEDITAAQLAQSSKEAVQVSTSSTTTSCVTSTNLSKLKLLAKGKVRDIYALPGKENEDKLLFVATDRMSAFDVIMNNGIPSKGITLTTLSLFWFDKLKNIIPNHVLYPSPSACFSTPAQAWEQFPRSLDEYRDQLEGRSMIVKKCEVVKIEAIVRGYITGSAWSEYKKSQTIHGIQMPAGLVESQKLPKALFTPSTKADQGEHDENIHPDKVKDICGPELAAEIEKVAIQLYTEAAAYALERGLILADTKFEFGLLPDPSSPNKTTLILIDEVLTPDSSRYWAADDYVVGQPQPSFDKQYLRDWLIKEGLRGKEDVTLLEHVVNETRSKYEEARDRVMGLGNFGKHGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUS0</accession>
    <name>A0ABR3BUS0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614379.1">
        <property type="nucleotide sequence ID" value="XM_066757995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990356"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="345" mass="37604" checksum="23A79EEEA5691795" modified="2025-10-08" version="1">MPRPPEDPDVRNSKTLAYILRHGAEKEGLHIRSDGFIKLADVLARPKLKGVDEPTIHHLVQTNAKKRFELFWGYDPSPPRPKKKPTQGKTKKQLQRDREAAAAAAAAPASSGTGTEIGQGKGKEPDAAAIDIISSSLASTDLTAPSLSLPTNPLSAQGSVSAEPPELPLISLPDPHDSDANASVNSDDPKGEYFIRATQGHSIQLESTAHLEQVKDDEEGRSKVGLMVHGTRWELWDTLKEQGLQKMTRQHIHLAPSFSGPITPRPNATLYIYLDLSKLVAAGIPVYVSANGVVLTPGSKAGENGKGAGVGKEFWRRAVRRKEGKRWVVWEDGREVEREELPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUY7</accession>
    <name>A0ABR3BUY7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614931.1">
        <property type="nucleotide sequence ID" value="XM_066757462.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989816"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="94" mass="10406" checksum="75351C797F8E258C" modified="2025-10-08" version="1">MTNLFEGLYHTVQGILQSIIAVFQSFFNVIYSLVHGVVSLVWNVLESIAEFVGASVHFVISNILIIGLIALGVVLYKDRNKRGTLGNDLKKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUZ1</accession>
    <name>A0ABR3BUZ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614454.1">
        <property type="nucleotide sequence ID" value="XM_066756985.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989297"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="258" mass="28394" checksum="62860153C5938AF4" modified="2025-10-08" version="1">MFGPAVIGFSSRGCFITGSNGKIALRQGALQKAFHSASKWAAKAHAAPSRPLATPLNSRSTVALTSPWPWRPITPSSKLPAHTILEERVIYARPLSFSPRKHFFLGFTLAGCGVMFWMMPDKPRMADWFSEDVGLFKRILGTINNYLFLDLPPFLAFAGTTLVAYRILFATARRVTKLSQIRTRSDGSQGIETKTSLRLQTGKQDLWGKGSGVRDLNIADVRVEAVPGRAGAMMTKSVHFIPECSHISLDALHSYCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVK6</accession>
    <name>A0ABR3BVK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615123.1">
        <property type="nucleotide sequence ID" value="XM_066756346.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988652"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="284" mass="31778" checksum="3CF3FFC44ADC2994" modified="2025-10-08" version="1">MSLSLDSTIKLASGNLIPRLGFGVYQARSKECEDAVKKAIEVGYRHVDTAQGYHNEENVGRAIRDSGVPRSSVFLTSKYMPSHTVYSPTEVLDVVRKSLKKVDRCGEDKPYIDLMLIHAPWGGEEGRKNNWEALALAQKEGWVKDIGVSNFGIHHLKALPPPVPAVNQIELHPFCQQRDIVKYCEEHGIAIEAYSPLARANKKYYDNAVLVKVAEKHGKEVAQVMLRWSLQKGYIPLPKSVTPSRIESNAVLYDFELDQEDMAEINGLDKGSEGAITWNPVNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVR5</accession>
    <name>A0ABR3BVR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102979</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614950.1">
        <property type="nucleotide sequence ID" value="XM_066757481.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989835"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="704"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="812" mass="89764" checksum="1999BEEECF82BC14" modified="2025-10-08" version="1">MSPQRNRPPHGAQTSSSSSRRGGATRARGANGSACDQCRKRKIRCTGETPACARCTRLNKECRYVDASSSAIAQTASYLEELQNQVRDLEARRSALRSLSPLNTAKETALPTDEGHHMHDARNGRHAQTYDGNPYQHAMSMNISDVDSPERQLPTADMSNRSAGLAQQTTNTSPVVSWDHHEPLRTQTHIPHLYSTTRSQHQHVDSTLNRGSQPTSPSATAAHPATLDSDEPSSRYEAISTTYPKPHDRPLPSNDQVLLHLPTDLGVVSILEQNSSTQKPLSSRITSLVCINRDILPPTDNVWFLIDHFEDFISAAFPIFHIPTLRLWVDNVCFRGEPVEAEIACSVLLVLAVSATSLARGSPYEYLKSRAASLWEYGQKFLPPVFLPPIDEQRGLLRVQVMLIRLQYVLYNPSAGNVWGLSGAAVRASVDLGLHHESGLRRNSRTAIETDIRRRVFWIAYSCDRDLGMALGRPPAIQDEWVTAQFPSDLDDSLITIDGLLPGPPSPSKQTAIHLFRIRKLQSSIIFRLYASGQTVRNPTNEWLADIQHSIEEWNDQKPRGRGFCSDEWLLLCYHQTTTLLHRPCPGNPTPSRDSLGKVLQGSSATMRLYKEVYRNGRISFGWLSMYHLFISGVTYLNSLWQGYRNGWRLVPSYIDALLDMQVCTSVMEGLAALTPGAVSIRNTWEAVSEQMIRQLSSHAPWDLLSRPSSPTAPNNHSRHIDSSMPPLNTSETWQAAQAGGVRSAMSIPNDNSGGSGTSSGAGNAMNGLMAMENPFDPFLLHPLGELSNDDWARAVASVFGPLDSTAELSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVU5</accession>
    <name>A0ABR3BVU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_103522</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614400.1">
        <property type="nucleotide sequence ID" value="XM_066758016.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990378"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="57"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="579" mass="63421" checksum="19E799FB7302C81D" modified="2025-10-08" version="1">MGRSHPPARDEIPPLASMGITLHPDTMAYVADPQALADAIGGNSLKDVFANWIVFGAAFSACMGGLLFGFDQGILSLVYVMPRFLKQFPEIDSTSGLPHTGLNKGLMTGLLELGAFLGAFQSGFLADRFSRKRTIGIGAIWFIVGSILQTTAFSYGHLTAGRFIGGVGIGLLSSTAPMYISEISPPNCRGAFLVLEGSSIVIGVVVMFYITYGTQYIPNSWCFRLPFLLQITPCVILVIGLWLLPYSPRWQVQVGRDQEALESLCRLRKLPATDPRIQAEWITMRADAIQAREVVVATHPRLVNSTGFAGELKLELAGWVDLFRPGVLNRTIIGIFLMLFQQFQGINALVYYSPTLFGELGLDTKLQIDLSGVLNIIQMIATCSAFFLLDRVGRKPPLIFGSIGNACSHFIVAGLIGKYQGKWDDHPAAAWTGVAFILYFMFSFGIGWSPVPWAIPAEISATSRRAKTVGLSVIANWLFNFIIGLITPPMIASIKYGTFIFFGAFSFMSLFWTIFFCPETKGKTLEDMDILFHTNAAHEERLARADIIALVCGSQQSAAFPRSGEKFDSTEHVEIASQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW13</accession>
    <name>A0ABR3BW13_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Solute carrier family 25, member 34/35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_101976</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615304.1">
        <property type="nucleotide sequence ID" value="XM_066756527.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988834"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="81"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="183"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0252584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31720" checksum="191E8FBBC783522C" modified="2025-10-08" version="1">MKTRLQLQGELQRADPSAPKVYRNVLDVFRKTWQHEGIRGLQRGLVPAYGYQTLLNGSRLGLYEPCRRLFNRAIGKDPNEGVFITAITAGAFTGCIGASLGSPLFLIKARMQAYSPHIPVGAQHYYKNSYDALRTILKSDGFFGLWRGVSTAILRTAMGSSVQLPSYNLSKYYLVSSAGMPADSFWTFLAASSVSGVCVCIAMQPPDTALTRMYNQNTIKDPITGKVRGALYTNPFDCLWKTFKAEGIAGWYKGTTAHFLRITPHTIFTLVFNELIMAQYSKWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWB1</accession>
    <name>A0ABR3BWB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic phosphate transporter pho88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615393.1">
        <property type="nucleotide sequence ID" value="XM_066756616.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988923"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20705" checksum="C2F7CBA631CBD934" modified="2025-10-08" version="1">MNNPAVTNLVLSLGAMQVARRIPMDDPQVVNYLRIAYATAQLLSLGIYYYITLQIRKKNDLTVLKYVNPASPMNPDAKPELVQTTVKDYDLAETGKAIRSLLISVAIMTFLHGYMKYTQPLFIQSIMGLKGALESNPAKLHLWNKKAEGDLARPFKASGGMFESLTGKATGPQTDAASIKEAEKAGKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX17</accession>
    <name>A0ABR3BX17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi to plasma membrane transport-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614583.1">
        <property type="nucleotide sequence ID" value="XM_066757114.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989426"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="851" mass="92689" checksum="C043841C2F5883E6" modified="2025-10-08" version="1">MDIDIDRWSEDERMDEDLGGEHMHGEQQDRDSDEVMGDGEGTIDVYEGEEEEGIDMDPPTQAEPVDVAPARSSTFSHPPSEGQDVSSRTPELEMRAATPGLLDGEQRNLPQSSAAHDESAAIEPQAAAHFPADSVALNATYEQEVRQTDGSAEECNIRETGKREHPEEVKDVLAADSTVLEEGADHALGRDARVSVNDPTTDSVQNDSVATSSRTIIAPQSDSSVTKEERIVPTSNDVYEDDGEYDDEQEYYDDEPLTPENLPSIILHLPERPLPPSVSPARALFDSVESDPGQIPVWLKNRQLELAEASLADVWGAIRAECAKEGLIQSAGDGLVITEKLMDLKMFEDDVNLQSITFLELMNLYHGCDLPEPVQLHLSWESSRFITRFSAIQSELEAAGSRSTSEELVHDQEDQDYNEVKDHKEKKLESIGGDYDDEDEDGYEEFGEREAVYDDEPENIDGNVEDESTEKEDIQAALDGHHDAEFEDADVNVDDTNAVSGPPEENVTTSHQRSETNEGNSRPSELPITDSKAADGAAGRDDNENKDDLVEIPNNSEADAGAVWPEESEEESPADGLLHETPTVGLPQATERNQADLTSESVIDATSMPGDGQADFGAEAEDDGSSDKDSRVSKDASSSMTHLSPKDLAAKNTLSSSTTSDDAGSVLFSEPDKSTLIVEQAEQSRLSIVVEENNPENAETSAKMEVMVEETVKSVRHAGVGENDADHLSSRLQNGNDVGVMGDKTEEGQPRDALAHAEVVPIEDEASSNDVEYGDEEELVEAIGDDDEGGYETNEGTLDDDEESKTIRASMPEETVVTADLVVEDDGTTIAPKRSYDSEGEEGENKRTRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX38</accession>
    <name>A0ABR3BX38_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615667.1">
        <property type="nucleotide sequence ID" value="XM_066756890.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989198"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0252947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="341" mass="37212" checksum="66FB2846197F010D" modified="2025-10-08" version="1">MPPSLVLFTTSQTPLAVRYPHPLRPILTVPPLLHRSLHNALDRDQPSAVFVGDAKGAGGVTQGTLYIPNLEELVNPSPLSVPNGHAAPEPVQDDTELTIKVHLTVSPTSIPTASAQAEWVGEALQVVRKAKCLPLPDNLLIGFKGIDYRGVKTATSAEGSLAPNTETIPAELEEEVLKVWERVFAERSRLVKEGGKLGSLYAPQGLLKKLREREEGRGRVKVNALDTPDCHHLPKEYTEYARKNGVELWAGGGGEGSDPVPSAHLQNVLQEFLPALRKIVPEEQVKELNKLDNSIPLHQDGSKFEDIETGVQVRWVLSYTALSTSRNVVKDRGYIIAADLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX94</accession>
    <name>A0ABR3BX94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_102649</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614658.1">
        <property type="nucleotide sequence ID" value="XM_066757189.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989505"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0250471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="125" mass="13537" checksum="51F6E8595353D9FE" modified="2025-10-08" version="1">MSRPSIEMNLPPSLLNFYQKQQEYAGLQALREASADLVARAEKLAEMSNIMADGGEAIGGVLRNWPHVFSILSLFTAQMEKASGDRSRQEDEEDEGPLSCLVRLAYGGETPSVESSAPTTTTASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXG7</accession>
    <name>A0ABR3BXG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_102206</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615534.1">
        <property type="nucleotide sequence ID" value="XM_066756757.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989064"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="11">
        <location>
            <begin position="92"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="344"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0252814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="390" mass="43727" checksum="05F01E629D25A8C5" modified="2025-10-08" version="1">MDIDEESYLNAGPSAPSEISQGGEGDKLQGMSKKAMKRAAKQARLEEIKPLKRAAERERRRQRTAQLAEGYAAGTLNEADKELVERRRRVERERKEAQRRVESGDQANDWLGGVVIDLGFDDLMTDQEIASMAQQLGYLYSSNRTAEKPVRTVIHTTFSPAASPRLWQRMENFNWHKWSRCHWWEQGLETLKSQLDPATSILCAQSVVSDKAQDKAGVDTKSLLSRLTGPQVPVDLQAGKHKLVYLSADAEDELLSLSEDEIYIIGGIVDRNRHKNLCQGKAEQLGIRTARLPIGTFLEMLPTRKVLTVNQVFDILVKYIHLSDWAAAFEAVIPIRKYAPGRKAKRAKLEAKKDERDEEEEGGTSAEGEETIGVAEKSAEVVPAEVFTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYZ9</accession>
    <name>A0ABR3BYZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP-binding protein ypt2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102118</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615446.1">
        <property type="nucleotide sequence ID" value="XM_066756669.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988976"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="211" mass="23416" checksum="78D30BD978D4B776" modified="2025-10-08" version="1">MSGPAGQHYDFLIKLLLIGDSGVGKSCLLLRFCEDSWTPSFITTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDEKSFNNIRTWLSNIEQHASPGVNKILIGNKCDWEEKRSVTIEQGRALADEFGLRFLETSAKANEGVEEAFFTLARDIKTRLIDSQPQEAAPVQLGADRGGVNVNKQSDSSSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ67</accession>
    <name>A0ABR3BZ67_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615521.1">
        <property type="nucleotide sequence ID" value="XM_066756744.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989051"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="244" mass="27692" checksum="036E353FB2CFE522" modified="2025-10-08" version="1">MASRLASLTPSKHARSRGSPSPSASPAQSPLRPTETTHHRMLKLVIGEIKNVIRTWDEIVILEGFKAAKGCVDESTEMDNILDVEERPEREEVGPHLAALYNHRVNLQTTINKLDNFLGKLCQLVDQAEKVLLGACQRETYDFVFVEPLWLTWTLEHCVNTMSTLIPHHTYHLAELSVLASTILDPSTAFDDAKNALEAWRDLATGGERWEAVRDWEELIELELTKAEEAEEEEDNTNGRRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZD2</accession>
    <name>A0ABR3BZD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_100873</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615722.1">
        <property type="nucleotide sequence ID" value="XM_066755436.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987731"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="669"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="729"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="521"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0253501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="834" mass="91749" checksum="FE2103A7AC590DE0" modified="2025-10-08" version="1">MSSQPPQDAPATPRSPRQPLPAPQPLAPDLELNPPRPRPNLSSMLFLTAFFFFMSGGNHAPATGGMEIGPDGEVRPRMSELEYVRGMRDEWRGWLNGTAGNYTEPAVPDMLPSAIVPSTYAHDPLQHGHRFYSNITGFYRHAAVHPRSLSEPRNDSLASFWNGSPLLPRPINETEGWNETRAEEMRGEWDWARTVRWDMNLKERNVSSSIDLSDDPPYSADENGYSEWAWVKGALTLTSRPVSVSSTSLDETITYNFYGLHHIPNGTYNLFALPEGMRPDIRRLPGLWGEARWGGEVGNETREIVLRELDKEVKVQQELFVLGDMRPDEVSETTTCPLLIHLTLPPIPSSSLASEIQAYHAELSNPTGLLASMKRPRGYSQLPPGLGGVVVADGCGWALGIEDGEGLGVDDFWRREVDYSVMIALTQLLLLYLLVHQMELTRTPSTLSKISIWTIALMAIIDSYVFSLNVILGVVDVGHGGADGRGGGLGVWVGGFAAFAGAVIFGPRYAVTLHRIQAPEGAAPPPTPAAPVTTATVASDSNNSTNANDPEGATNAEDVNGGRNRFAGLRSVTEGFGQMFRGRPAVNWIVMALLFFLLGPLLFTPSVFPIFLTSLYSFWVPQIWRNARRGNGRALGWGFVLGMSGGRLVLPLYAFAYSNNMFFTEPKRWVWGLVAWQVVQVGVLYAQERFGPAFFLPKSMAPPESYNYHPIIPPADAENPSPYDGETTCSICYEEVDLYPRSGTLSLSTHVHGRSNSLDKKSSFSVSPTVISSKDKISREKESEREGLLGGLGGLDRRNYAIAPCGHVFHTSCLVQWMSIKTICPLCKRSLPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZD8</accession>
    <name>A0ABR3BZD8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615975.1">
        <property type="nucleotide sequence ID" value="XM_066755689.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987988"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="168"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0253754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="745" mass="80328" checksum="A7FAF0BE0132232C" modified="2025-10-08" version="1">MEPQQISTPNTAEPGHLSTGFSSSESYHPDHTSTFAVSAAPSASFAPADAGPSPRISIPAQSISTELPGYPYQNSDDANGSGRGRGRGRGRGRGRGSRGGRGSRGVRGGMRASTRLSERNASGSGGVAKLKLSFKSGGVTEASGGRMSSFLGEYDRELDENPEEPLCFEEQFILRVPRDVAEGKNGVTGLRDMVKGKGKGLDGVEFKFLDPRRAAFKVNNMTYAAKLVDLPNIIEAQKTFDNRHLFKIADISQMLIVENPVADEASITEKPLKIDEYIWPHGITPPMKHVRKRRFRKRMSRLAIEVVEESVEDLLKKDDEAEDTAFDLIDVHQDPDIDDQYYIDYDPNGAWQHYNQGDMGSEYGGSEMYDDPGSVAPSQMEDWGEGGTDWGTEMGDEGEGDYERGEEDYGDDGTLDQELAAALMEGTGASEFTGLSEDDGVTSGSEDDDDDDEGDKSEYDEETLEKRAKIKQFTSEIKALEAIIDKKRAGFAGGNPIMVKRFEETIAGLQADVTAKIGARQALVDEIGKAEEGATVEAAKQKEEAAETAVVREGAEHRDAKESTVATETLMDVDLDEGGDGYSEAPTPVAGKDGEQASSPHYSDGDDLFGDDDDDEDVEAVQDGHGEENAVQQGDDEEDEMARLLRAELDGLDPNAVDETADIPEDQEQVDAAASAALDSFAMSDAFGQFPAQEESGSLGGFDFPESMEQITVSGFVEGGVGRRRLAMGAEAGDIEDESSEDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZS5</accession>
    <name>A0ABR3BZS5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616107.1">
        <property type="nucleotide sequence ID" value="XM_066755821.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988122"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="79" mass="8564" checksum="EEF754D9E033AC46" modified="2025-10-08" version="1">MSGNNDNSEKTFNILPHPAKTNNPADWTGDPGERGGLQSSSANAFNAKPPYIPSKEIAEGLEKPKTREELRAEAQQLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZT9</accession>
    <name>A0ABR3BZT9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="12">ETF-QO</shortName>
            <ecNumber evidence="12">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_101273</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="12"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616116.1">
        <property type="nucleotide sequence ID" value="XM_066755830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988131"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="11 12" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="575"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0253895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="615" mass="67131" checksum="A0192519B04D8C1E" modified="2025-10-08" version="1">MTITAPISRLLKYRTLPTASRSSSGALLRPLRALRIRTFASEAKFDPESVERAQDEVDVCIVGGGPAGLSAAIRLKQLEQERGGDELRVVVLEKGGEVGAHILSGAVIEPRALNELIPDWKELGAPLNQPALSDSMRFLTSNSSFPLPHPPQMNNKGNYIVSLSRFTAWLGEQAEALGVEVYPGFAGAKVLYTEDGKGIKGVITGDVGLDKEGNPKDNYEPGMEFHAKVTLIAEGAHGSLSKQLQKKFNLREGKDPQTYGLGIKEVWKVKDEVYEPGKVVHTLGWPLDYKTYGGSWMYHMEDNMVSIGLVVGLDYQNPYLSPYKEFQRMKHHPFFANILKDGQCIAYGARALNEGGFQSIPKLHFPGGALIGCSAGFLNVPKIKGTHNAMKSGMLAAESAFAAITSAESSEETSLDINPVDMSNYATAIENSWIWSELKEVRNLRPSFHNPLGLWGGMAYSGLDSLILKGRVPWTFRNSVEDYEATKKASEEKPIDYPQPDGKLSFDILTSVSMTGTNHAENQPVHLRLPNVEGAKALHTKINVEDYAGLLGRVCPAAVYEYADAEGSEVDADGKKFVINSQNCIHCKTCSIKTPTQDITWDVPEGGGGPKYTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZW6</accession>
    <name>A0ABR3BZW6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Atypical/ABC1/ABC1-C protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616144.1">
        <property type="nucleotide sequence ID" value="XM_066755858.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988159"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="549"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="DnaJ homologue subfamily C member 28 conserved" evidence="5">
        <location>
            <begin position="297"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="4">
        <location>
            <begin position="712"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="4">
        <location>
            <begin position="780"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1189" mass="132645" checksum="DCF50FF54A612992" modified="2025-10-08" version="1">MIPIRHKSCSLASLAGRALPRTACRAPQQYRSSSSSATPPADQAEHQPKPLTGSARLFADAEAEEKVTSNASDRDHLRLTQGPVWTGDESTADAVLRMLVDAHKPMRNEGGVKHNAADEKIKGWMKGLQLEPRLGLGSSLPPEEVQEIGLERVEKESPHRTKIPPHLHRPWHATYTGDSQAAETPNVKYGAFINRRTDGDSLTNLLELQLPPNADGKNRAKVKAARQSTKFVGRLDKAREGALDYKLGLGVDDTHIVETGDEGEEGQTFKGNRQIKGSSVLGAQRGRASGMKAWAGLVEGRIQRAREAGFFNNASGKGKPIVADPEERNPHIERGELFMNRIIKRQGALPPWIELQNLLDSNLGSFRSTLLTTYKTQLVRNVISTNALHPLPPLHAIPDRDEAWEARESKFHQENVKQINDLVRRMNAQAPSPARRNLITLEGELSKIRGEVLKNEVWEEIKKRAEESINMPYQRERPGLAPFIFDGEGWTKLKNITRRTFGTRAVSGTAPSINTNVGALEGYSKAYSGGAKGNHSSEPGTHSGRDPRPLRLVIMAGVGVGVIIYLRRRPVKNDSADLIPVHRPLQSIPPPQPDIVASSPSEPPLTFSRIIDIYIFEPIGTFFRFFYLACLFTPVILLTPMLLVGKPGKRHRSLIGRPISEEDQSWGAIWWYGFLVKQMERAGPSFIKLGQWAASRADLFPAALCEKMSKLHSNGKPHSLGYTKKVMEAAFGMSFDDIFEEFDEEPIGCGAIAQVYKAKLTPKILADTKLDGLPRSAESDTASVAIKVIHPRVSKTIRRDIAIMSIFANIINAFPGMQWFSLPEEVQVFGEMMNSQLDLRVEASNLDKFLHNFDKRGRRVTFPTPIRLSDGKKELEEEMKEVLVEEFEDALPLKYFLQNGGGPYDHKIANIGLDAFLEMLLIDNWTHGDLHPGNIMVRFYKPTTTDYLSPLLHAFGKDPTPSTDESVASHDSLVHTLAAVSKDSEKWLNKLDDLHQEGYEPQLIFIDAGLVTSLDKKNRRNFLDLFQAVAEFDGYKAGKLMIERCRTPDFAIDEETFALKMQHIVLSVKSKTFSLAKIKISDILTDVLKAVRQHHVKMEGDFVNTVISILLLEGIGRQLDPDMDLFKSALPILRQLGKQMGTREAIQATPTGNILAMIKLWVWVEARQVAGEVSTLDEWIKYDRLMPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C007</accession>
    <name>A0ABR3C007_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615569.1">
        <property type="nucleotide sequence ID" value="XM_066756792.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989099"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="303"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="548" mass="61053" checksum="05DF66F2FAF00305" modified="2025-10-08" version="1">MSHFDTVSRTTSRAGSTVSRNQSLIKKNTAPHELKPSDILIERFQAWKGIVKMLISYFEGIADIEANTSKELTKLGAVIQVPFRPGNQFLGEGGMQDVFYTIRDKTRLIADSHASLARTIESSIVQHLQKLRTEIKAHIKNVQNDTGKLATSVAKERELSTRAIADLARAINAVNNTPMQVSSKEDPFAVNQAVMKQLQKQVNEENALQKSIIIMQQNSAHFEEGIVRSVQSAWATFDEWQTRMSTSVQETWRQLGVNMAQLMPDREWISFAARSDHLLDPETPLRNIDLIDYPGKSDPSVAPVYTGMLERKKRFTKSYKEGFYVLTPAGYLHEYASSDPSTATHPIWSLFLPACTLGPPSSASTAKSHKFHIEGRKDGTSAHGKTPGGRGLFRGSDTAFTFRARSHEEMMEVWNDLRMLVARYLVASEQMEREGPISQAVRSVGYGSEEEEEEEEEEEEDEGSSVEEAEEEEEEVQDDAHTAEEEVPAYSHGGAAPIEVGPNGYAIDKKEKPELGPEAETGSDARAPQLSRREEKAPAREQPTTADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C037</accession>
    <name>A0ABR3C037_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-carnitine dehydratase/bile acid-inducible protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616219.1">
        <property type="nucleotide sequence ID" value="XM_066755933.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988235"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="49861" checksum="13836975A7A40305" modified="2025-10-08" version="1">MLRMALFRLKPLQSGKTLSAPPGVQLYASSISHLRSFSTPAIVNDDRPLAGIKVVDLTRILAGPFATMMLSDLGADVIKIESPKNGDDTRSWLPPSAPVPLEDYPRPDLPPESAYFMQANRNKRSLTLNLKSVKGQKIIKRLIKEADVLVENYVPGKLKKFGLSWEEVKEMNPRLIYCSITGYGSTGPYSKSPGYDVVIEAEAGLMHITGEKDGKPVKVGVAVTDVLTGHYAQSGILAALLKRQKTGKGSRVECSLFESQIASLCNIGANYLIAGQEATRWGTSHPSIVPYQVFPTKDSFIMLSAGNDSQFAILCSPAMLNKPDWLNDDRFSENHKRVENRDVMISLIEEVLSEKTTEEWCQKLTGKGLPFAPINNIAQTFSHPQAIAREVVEEVVHPRAGKIKLAAPAVTYDGSKPKLYRPPPYLGQHTEEVLTELGYNSDEIKKMQVDGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0F3</accession>
    <name>A0ABR3C0F3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615856.1">
        <property type="nucleotide sequence ID" value="XM_066755570.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987868"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="104"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="10">
        <location>
            <begin position="281"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0253635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="348" mass="37608" checksum="C88A71C07A229F9F" modified="2025-10-08" version="1">MSREQEQDPFVNQQGEEAEEEDFESLAPLLVAKLQEAGISAQDTKKLSDAGFHTVEAVAFTPKKTLCTIKGISEQKADKILAEACKMVPMGFTTATEIHSRRSELVHITTGSTGLDTILGGGIETGAITELYGEFRTGKSQLCHTLAVTCQLPVSMGGGEGKCLYIDTEGTFRPVRMLAVAERYGLDGEEVLDNIAYARAYNADHQLQLLVQASAMMAESRFSLLIVDSCTSLYRTDFSGRGELSARQMHLAKFLRTLMRLADEFGVAVVVTNQVVAQVDGGQFAVADAKKPIGGNIMAHASTTRLNLRKGRGTSRVCKIVDSPCLPEAEAIFAINPNGIGDPEELQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0U3</accession>
    <name>A0ABR3C0U3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_101628</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616468.1">
        <property type="nucleotide sequence ID" value="XM_066756182.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988486"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="656"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="818"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="903"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="943"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0254247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1005" mass="110185" checksum="F75277A730970936" modified="2025-10-08" version="1">MAAQSSRPHHHRVRPRSHSRSSSSPSPPPSPLQHNHIHPHSSPRGSPSSLVREKRRSFNVNRTSVLSAGGHRTRALSRGAIPAFPNTDDRRPNPGDENALVVDTDGVGFSTQYGASASSMTGVSGSEQEFLTGLRDETETEVESDRKDTTQWRRSVDDPVDRAPTPLASNNPRHTISSRRLIPQTAPPFTLLPFRLGFSGYSLSIKFDWKSQERIWNLSIKMTRRGCENALVLGAVLWGIWVLVVRWNEKAVAGEIGLLVGLTLLYTALRFQPTPQRLLSQPPPTNRPTSPAFAPPNWGSSFARERIRRTSISNSNGSLSPSFPKDYLRGRAFSPDEDGRVGIGERACIWGTEEREYRECPDDGIFYSLLLGPLVAAALLHSALSQLSSNPSSPVAKGWNIESPLVLPSTPIRRGASITDAEPTDTIRALSALATSRRNLVQLFTLCSFVLLVHVTRSLHLEITQFRINYPPNSTSPDAEVTKLHSLQAQQANIGTYWLRKGEWKRTRSVVGFSFLVTGVCLLVKAVTAKVGRGVWSDMSPSDIVIATLFYQFSIYVCVRLARRGVTLGELAAVCNAATAMVMETTNLTRMKISIFRTPYIKTYRLPTPLLIFQLALIPGSLLAGFLLSPLLYLSRNLAQKPAHRLRLPHEKPVHRRLLALGFYAGSVLICGGLIGVWTKWCLGGRNPFTWAFFFIFEGTHAWTRPALIAYWVALAAISVAGWERQLNRARKHRRYVVPGTAAIRGEGPGGQHSVAGGPAGKPLGLGSGNVLGIATSGGQPGGTTQEGFTGVATQMMDAADQRMPTLSVNARRKSFHALAVIMFIPGIAVDPAFTHLSFSVAFAAFNFVEYVRYFALWPFGVKVHLFLNEFLDHKDSGTAILSHFYLLAGCAAPLWFEGSSDILSYFGVLSLGIGDALASIVGRRIGRLRWCSVFGKTVEGSVAFFFSVLGASWVMWLFGIVDDFNFKPYTITVALATLLEAFSAQNDNLILPMFGWAVGTLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1A0</accession>
    <name>A0ABR3C1A0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L37a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616400.1">
        <property type="nucleotide sequence ID" value="XM_066756114.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988417"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="92" mass="10063" checksum="0E12F570277DB0EE" modified="2025-10-08" version="1">MTKRTKKVGVTGKYGTRYGASLRKTVKKMEITQHARYSCPNCGKVAVKRTNVGIWACKGCNKSYAGGAYTFGTPSAATVRSTIRRLREVAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C203</accession>
    <name>A0ABR3C203_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615790.1">
        <property type="nucleotide sequence ID" value="XM_066755504.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987800"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="301" mass="34285" checksum="F298D6BEED97DFCB" modified="2025-10-08" version="1">MPAKPILPIRQDDSDDSNESYYDEQGELPLRHAYIHSLANLLHACLLRGDIDRAKRAWAILIRCREVDWRARWQWGLLFLSSGSSDVVQNTQASMYASQAEDDYRQAERWINTLRVGARMEDKPSLLHALTLILIKHARYRQALEELETYLPSYPYLLSASLHTYAGLLAFYLAQPSSAIRQPTPAASQYDNLLGRADCDSTATSQRSSRSPSPLPDGWEHADGNLMRQARQWFAKAIEIDEKEDVAREFLRVIDQPNPGAEEDKSESDEDMESVQDEISEEEGYSDESEKIGLADEYESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C244</accession>
    <name>A0ABR3C244_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_100988</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615835.1">
        <property type="nucleotide sequence ID" value="XM_066755549.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987846"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="90"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="277"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0253614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="442" mass="49728" checksum="F472F373C2473849" modified="2025-10-08" version="1">MTNSTNLNLITKMSRPDEEELVDYDEAAEEILPPAPAAETNGDKADGDKKGSYVGIHSTGFRDFLLKPELLRAISDLGFEHPSEVQQECIPQAILGTDVLCQAKSGMGKTAVFVLAALQQIEPVDGEVSIIILCHTRELAYQIKNEFTRFSKFMTNVRTGVFYGGTPISADQEILANKEKCPHIVVGTPGRTMALVRDKKLNASKVKHFVLDECDKMLEQLDMRRDVQEIFRATPHHKQVMMFSATLSKDIRATCKKFMQSPLEIYVDDETKLTLHGLQQFYLKLEEREKNRKLNDLLDNLEFNQVCIFVKSVQRATQLDALLQECNFPSICIHSGLQQAERISRFQQFKAFEKRILVATDIFGRGIDVERVNVVINYDAPADADSYLHRVGRAGRFGTKGLAISFVSSDADQEVLQKIQERFTVAIPTLPETVDPATYMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C2G7</accession>
    <name>A0ABR3C2G7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615955.1">
        <property type="nucleotide sequence ID" value="XM_066755669.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987968"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="222" mass="23343" checksum="E3613E3EA361124D" modified="2025-10-08" version="1">MSFRTATRFTARFAAQRNSTHLIARRTASSSAGPKTGSDTPWIIGSTIGFGTLAAFILFPSGKDAAKHAVPHSHEKADISEHAPKVSPGNENVQSSNTIERAVASDDPKDVNPIANEPAGEIPSKKEGKGDKAGEDQKPEAKSGGANANKTAQVQKSADANKGEEKTEENKEEKREEKQQGSEEGSPSAQDIKDSIVQAAKANAPEVAMDAEAKGESPIGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C2M9</accession>
    <name>A0ABR3C2M9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616015.1">
        <property type="nucleotide sequence ID" value="XM_066755729.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988029"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0253794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="127" mass="13696" checksum="E5544019B58D982F" modified="2025-10-08" version="1">MSWQAYVDDHLVATGKVKKAAILGKQGGVWAASSGYNLSQQEQNSITQTFFQQPDSVRANGITLNGFKFMCIQATPEEVIGRKGERGVFVIPTNQAILVAEYDAPTSAGEANVVVAKLADWLKSASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3L2</accession>
    <name>A0ABR3C3L2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="1">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_100008</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616490.1">
        <property type="nucleotide sequence ID" value="XM_066754589.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986866"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme synthase central" evidence="14">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="13">
        <location>
            <begin position="441"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="12">
        <location>
            <begin position="504"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="402"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0255213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="796" mass="87354" checksum="3AC1E083D05F8C59" modified="2025-10-08" version="1">MSSSASPPPVWISFWMLLTTLIVSWDAGYCLMRPRSFSGGDLSWIWKPYNDFPYGEIDYLYGWKAFNERDGFTAAQALLNIVEILLAVDYLYLRHISPRDKRLQKYHAVAPLVGFAGAVMTASKTILYFLQEYLCGWCNVGHNDRRTFWMVWVIPNGTWIILPTIVSIVLGRYIAAALERDAIYSSASNSLPPAEFLAGKSDTTLTEEPTQLSAALPLTFHPRALSVLIVGSNRLAATRALSFLEADAKVFLLTTSEVVVKEVKELEESGRISLLQSAASNSVVWSELLAKHDISLACVTDTLISTPSRRSFASATVIYQTCLSLHIPINISDQPLLSTYTFPSVHRFAGADGPSHLQVAVSTNGQGCRMSGRIKREIVSRLPADVGKAVDNVGRLRTRAKARAKLSEEDDGPLNTPVPQLSTPSTSRPNSNGEVTQQLSEEEQQLRRMRWVYQMSEYYSFEHLAKISTEEMDKALEIWGQRNEGYLPHHDAKVANASEKKGRILLIGSGPGHPGLLTMAAHTALRTATLVLSDKLVPAEILALIPDSTKLHIAKKFPGNAEGAQNEMMELALEGAQRGETVVRLKQGDPFVYGRGGEEVLYFRQHGFESTVIPGISSALAAPLMMGIPVTQRGVAESLVLCTGVGRQGKAVQLPGYVKSRTLVMLMGVARISQIIEVLTSSNAAGRDGAAYPPHLPIAVIERASSPDQRVILSTLEKIQPALKQVDERPPGMMLVGWAALALEGKGRVDVLDRAEDCEVEMVESWLAEGQEGEIKGWKIREGLNDEWRGILNGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C444</accession>
    <name>A0ABR3C444_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616672.1">
        <property type="nucleotide sequence ID" value="XM_066754771.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987057"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="316" mass="34510" checksum="9A6D057964D673FC" modified="2025-10-08" version="1">MNVASDSGHKGKLSQTQPEAQQEAPVQHSTATSRDPRFIDHHLDEETDLSHVRGKFQSIVSRVEELFGILYDTTKPYSDKVVAVAEQYPILFTFAFTWIAFSSIPIIIFTGFIVFCTVTIFAIATFFIFATIIGIVLLTFSAAIGTLVLALAILLPILAITTILSALTLSFLLGLFVIHRLYLHLSSATSNEWSIETVGEGFKGWVEEVGEKVGLNGSESVVLKQSSYDDDDGRATGEKSDSSGNVTSTTAASESERDGHIEDEKAGTQELSMVTSNTLDKIIQKHDGRHLQNLHPLSNAVSIHTEDRSHIGIKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4H6</accession>
    <name>A0ABR3C4H6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100332</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616805.1">
        <property type="nucleotide sequence ID" value="XM_066754904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987190"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1299"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="541"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="906"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="557"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="908"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1614" mass="182315" checksum="D526F517AB11EDD0" modified="2025-10-08" version="1">MSDVWPATSSYMLELSHRKYDLSQLAKAVDTAAKAKDNPGDAYVAPPPTPTCFHVHMNTIEATLLPPEATIEYYGREPEPNPAWQIFQSIREQVASIVPSMGRMSLVHPTASLIRQSTNPANAPSAAAVGTCLYLPKHGDRYPLARLELPAIAEQKEWMPSATAWDMQHWIHTIIALDPEFNTTRKTIYRDDKERIHMQTAIDICWVPDEAGEADRAEVKLLIISHVYLDMSFLFDPLPDVGNDMLGFILHSIIPSPTAAAYASESEARAAGLRDFYACLKPAPDLPFNFPANRLQPKEMLSKLLPFQMRTVRLLLEREGAQGVGKGVIRTQRDPDGLWKGLDWGNNFGSVNTGIPGKGKQRAYEEEDADHYMSGITEEEREKLPTLLDLTGIRGTMLCEEMGLGKTVEAIALLSLHRHPLSTPRNIPLMTPSVSTGTSQSHAHAQAANQPVPAINLLAGVPGLHDLEVKEWVEKENIAFAGRRAWDEHSQLEVTEVAATLIVTPPSLLKQWVAEIQYHAPTIRVCVYEGWKSLQQGVEKQRDARRKARARKELEQKKRKAAAFRGQTRRKYAKGNDGLAIKMESDEENYQDDEQEEGTLQVTQRQFVEYVRAHDVVVTTYQDRNLSRPEVCITGPSKKSPLVMVEWWRVIMDEVQLHGDQTDAANMVSLIPRKNSLAVSGTPARSDIKDLMGSLKFLRVPILPHDNRLWHRLQQSSMRPAFEGLFRSLAVRTTKKEVSGEFNLPHQSRYVVPIELSEIELHYYNDTLERARERLHLPANFREARPDDWVLDRGMFQIILRSLRQICTHIQVGQMQSGTGRGDQRLRLGRTLMTMSEALEKMRDDHLQETSSEARQQMRMMIRQAQLTVMDDQNDLRHLQALALYERTRAAAESHLEPAQKRLKALLDESDGNGKEEDEQFEDEMSEKQQTQQEKARALAIQTAKHTIRELDLIIHQCWFFEGDVRHVQKEEEKEVYAYARADAIRKSILARPLKTANMSVDLLKGSLIRGPAVAQVNELQTTDLKRRGGILTQDVISQANALLKIMNDNALLVFNWRKKIIDLLSSPIDVDPTDVPEGQGQEVENPEAEYYAEALKAQGEVEAYLIAFAAAVADRKEFMTETRSLLSTHDSRIAKQRNTQAAMNANTDVEMPNIPHDIGEQAAVLLKERQAFRDARMSKGCERPLKGLLMDLNEIAKSMASMLKKYIAEQTELVEKLNKELDMFRATFNRRVVYFASLQEISDSVTAPEFKDLGKDIHVAAKEVNELEVKLAKMAVKGRYLHYLGTKQHEEDDIREDCIICFGSSDDNQAVLLQCGHYFCLSCYREYRKTPGGRKCPSCRIKISDKEVQRIKLNTSRAEAADPMGKQHQTSVQTLAPAVSVSLHEAEEDITPEEQEQMRRAEDLEKLRMMDVERRRAVMMMDMMGEYGSKINFLIKHLLYYKSTEPDARHVIFSNWSDSLNIVMQALRLNGISFASFDQGKKQKDVVDQFLKDESISVFLLHAERESSGLTLTSCRVVHLLEPVLRHSFELQAIGRVDRLGQEKETSVFCYATMDTVESRILSQGVRNGTSIYLADDTADQVVAEMSNVASAAHKGGDVAAGGNEEDLLGLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4L9</accession>
    <name>A0ABR3C4L9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616855.1">
        <property type="nucleotide sequence ID" value="XM_066754954.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987241"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="50"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="544" mass="58596" checksum="F2F208084F2FE4F4" modified="2025-10-08" version="1">MISRQLTRNLFNKRAASTLAADINAAQDNGRWKGTSTLGGDAKLLIGGSWESSKTDKWSEVHDPSTQRLISKVPHATPSEMKRIVDVAENKFYEWSESSVLTRQRIMLDLQGLIRKYHKDIARNIVLEQGKTFADAMGDVTRGLQVVQMATNIPTELLGRNIEVSRDMDTLTRIEPLGVGAAICPFNFPAMIPLWSVAMAIATGNTLILKPSERDPGASAIIAELCEMAGLPSGVINILHGGVDAVNFICDEPRIKAISFVGGDKAGKHIYDRAGALGKRVQAQLGAKSEWITIVVRADSLDHAIILPDANKSALKAVAGAAFGAAGQRCMALSVLVTVGDANWLPGLIEEAKALKMGNGFDEAADLGPVISPQARERIEQLIESCEKQGGRIVLDGRGATVKDYPNGNWVGPTILEATTDMDCYKNEIFGPALVVVKARDLNEAIELVNRNPYGNGAAIFTQSAVSSRKFEKKIEAGQVGINVPIPVPLPMFSWSGNKASVLGGASLYGPLGLNFWTKTKTITSLWREDAKEDKAAVAMPVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4S1</accession>
    <name>A0ABR3C4S1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_100425</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616897.1">
        <property type="nucleotide sequence ID" value="XM_066754996.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987283"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="186"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="452"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="692"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1027"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1038"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0255620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1060" mass="117097" checksum="BC1CFDEB8E41505A" modified="2025-10-08" version="1">MKILKMAPAATAAASSGKGSFDLATLFVADKAARDEAGLALTDAVKKSGVEFFTQIGFNDAIVKALNDKKSQSAREGACEVISTLCENGAAQLLEPHVISSAENTPFPALLEAFADKVAAVKTAAIAAVKAIVQSMNPWACFVLLPALLNLIRTSGKWQIKAGSLEILQQLITSAPYQMGEAMPDLVPVLAEAVWDTKSDVKKAAKATLEKAVSLVENKDIEKFVPALVKSLLNPIEEVPKTITLLSATTFVSEVTAPTISLIAPLLIRGLDERPTATKRKVCVIADNMSKLVDSEYTVRPFLPQLLPRLIKTSETIADPEARSVANRAIVTLRRIGKVPAESDGSDLPPLPVAEGPHLATNFVALVKKHGGVSVEQTNPGLAYAGVLAASLVNHHNFDQKTWESTLPPYLKLALPSYDSLPAVRELLQKKADEAETDDAKFPDEEEGEDLCNIEQFNLAYGAKILLHHANMRLKRGHRYGLCGRNGSGKSTLMNAIINNQVEGFPPPSEVRTFYVQHDIDGSEAEISILDWVLGDKRLLATPEEIKSTLESVGFDEVKQKNSIGSLSGGWKMKLALARAILFKADILLLDEPTNHLDVLNVDWLINYLTSLTRCTSIIVSHDSDFLNRTVTDVLHLNNFKLKRYPGNLEEFVKHVPEAKSYYQLDVAEDYQFKLPNPPLLDGVKTKEKSLLKMRNVSFQYPGSSIQQLYDISLQVSLSSRVAILGPNGSGKSTLVKLLTGETEPNLGGQVWKHPNLVIGYVAQHAFHHIDNHLDSTPLEYMLWRYQTGEDLEEMHKANRVMTEAELAKMKEGATVIKDGVKRIIDELVARKKLKQSYEYEVSFKGMSSAENMWISRDELVARGFEKKVMELDTREAQRLGLMRPLVRREIEKHFEDFGLDAEFVSHNSMRGLSGGQKVKVVLGAATWRRPHIICLDEPTNYLDRESLAALIAALKNFEGGVLIITHNREFSESICTEVWAMREGHLEASGHNWVEGQGSGERIDKKAADDDEVEYDALGNPIAKAKKEKKLSAADKRKAKKDRMARRKRGEEVFTDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5C9</accession>
    <name>A0ABR3C5C9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100179</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616652.1">
        <property type="nucleotide sequence ID" value="XM_066754751.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987037"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="9">
        <location>
            <begin position="32"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="8">
        <location>
            <begin position="234"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="39057" checksum="57F102FE98741958" modified="2025-10-08" version="1">MSSPSAPSGNSPSPFLQEEEERLEVSDRKDASSVWALKVPNFLLQRWQTVQEPGVELGRLVVDNSVTPPNITLKLTNAEEGTEEGERAKRAKYDVEGLPDEFKVEVPMERSKNTFLFSEVKKVYDKGSKQREQQTDAPRDAWGKRKREKAHPKLLARVDHEGHIQPIRTQKYLDFLKARRMEAEQSRRPVVRMEDTGLSQAEQNQLASGFRSANSTFGSNMILASKQASGERFARLERHELTDRIFQCFRDHPYWALGALKQTLEQPDAWLREVLRDVAEQVKEGQYQGYWQLKPVWREDAWKGGENGESVKNEVKEEGDVKPDIDEGDDEDEDDLEEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5E6</accession>
    <name>A0ABR3C5E6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616848.1">
        <property type="nucleotide sequence ID" value="XM_066754947.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987234"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="233" mass="25166" checksum="38D0F391339E6B47" modified="2025-10-08" version="1">MFGIKKKLSALIPSDARAHLQNVFTVEWEGGNKTVLVEVPDADHPSEVEMSGMGGTYGRLADDDEDDIYSLPAQQARKSSHKSSSYTNKSKVLPRITQQQKYGDFYDSYSSKSVIDGNHYGHTRSNTNSFGGDCQASPQTSSSSTQTVSPYSSASSQFNSPSFFHPNTYHQNSSYGQGQSSGGREGNSRTAHRTDDVDDLLGGGDLGGIDYSARLNGTRDPGASVERGTNPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5P3</accession>
    <name>A0ABR3C5P3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional adapter 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100746</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617212.1">
        <property type="nucleotide sequence ID" value="XM_066755311.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987604"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="73570" checksum="D8737A0420945199" modified="2025-10-08" version="1">MPRQFPNPLHPLLHSTTYPQLPSVSDLETIRQALAEYASSASGSGSSVNGGSGAGASAGGFGGVGTGMGADGGGTPGAMGDDVKKKDKKRKEREDEDGERERDKEKEKEKERERAAIEANERASMRLEMAEKARLAHAHGHGGQGVAGKKKGLSAVAGKGSSTASPTGVKVKRERSLSPAASNASTTSFKPSASQQTYSGQIKKKKKIKRVLDSDDETPSTRDRSMTLASPPPPPHPHPSTTSGLKLKISHTQPKRPSVDASHSPSSSSTPLPGAHIDFTLPAQPSRPLVPTRQGPRQPMKPGPKKQSEVDEDYSNKKAPNQVAFPTFWSAVEPYLRDVREDDLAMLGFKTDPAESYEIPPKGRHYTEVWDEEDGNPPGTRTRFPVPNLRQQQIQQSQQGLNHTRKNTLALSGGAGTATQMIPHFVPAQEMKDENLVDEQRGLGALTERVVAAVVGTFVGDDKERERERRERERERVRMENGEVGGERVDPVKVDVVDLEERMKHELRAVMLLGEHEEFDPNNRDDDEITSALRQCQRLLVHQTALNEARKTRLAEIAKQRLAYTEYRAALDGVEKSIEEAWLKRIKKYGLSPKKKLMVEAGGPGTVIGEHGEVVQLNASGRPPVPDTLKRLVDTRKGWMGSVGQVIKERPRGELVGIPGESVYKGIEEGESSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6A5</accession>
    <name>A0ABR3C6A5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100821</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617286.1">
        <property type="nucleotide sequence ID" value="XM_066755385.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987679"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="9">
        <location>
            <begin position="19"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0256009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="477" mass="51885" checksum="AC92D05BA204BC70" modified="2025-10-08" version="1">MASSVPVPTDFNACLYKPLAEADPEINSLIEKETWRQFSGLELIASENLTSLAVMEANGSMLTNKYSEGLPGARYYGGNEYIDVIENLTRERALKAFNLDPKVWGVNVQPYSGSTANFAAFTALISPQDRVMGLGLPDGGHLTHGYYTAKKKITASSIYFQSFPYRVDPKTGIIDYPQLETNANLFKPRLLVCGGSAYPRDWDYGRLRKIADGQGAYLMSDMAHISGLVAAAEQNSPFEYCDVVTTTTHKTLRGPRAGLIFFRKDKESDLEARVNAAVFPACQGGPHNNTIAGIAVALKQAADPAFKQYAKQVRANAAAMASVLFKHGYRLQTDGTENHLILWDLRPIGLTGSKVEKICDAAHITLNKNAVAGDTSALVPGGVRIGTSALTSRSMKEQDVEKVAEFLHRVVQIALKTQEEAGSKLLKDFVKAYESGNGEAPKLIAELKEDVMKFATSFPLPGIPDSSKIVRPEGVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C738</accession>
    <name>A0ABR3C738_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616586.1">
        <property type="nucleotide sequence ID" value="XM_066754685.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986964"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045987976" evidence="3">
        <location>
            <begin position="19"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="364" mass="40511" checksum="052D5F8256F52560" modified="2025-10-08" version="1">MTRIALLTTALLAITAHAAKSNWGEACAQANTHLSQDTYELVTDCNPLTYCADNGTCAWKGCRKDIYPYGYNDYDFDQLPPLCPTGQFCPDEADQCLNQVPVGGSCQKDRDNECQPPPNWKQLNGYLNTNGSICLDYICYYSNVTVGQTCVNDNTAYTAYRDDGSAYAFIVSRDNCANGHYCDATDLLCHKSKAFGATCSGNKECLSYNCEDNGKCGKPANDVIHPPAWQYVLIGLGIVILIVAVMTGLWFMHRRWRNEKQVMLEQYYNEQIAYRQSIMSMSHAKQSLLSLPPNTTAGAARASLYGDTAWTSGTDYHSLPLPPNLRRDSSSRWSHDSDQVGQDSEVLLMQNGRYADMPEASKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C791</accession>
    <name>A0ABR3C791_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription activator of gluconeogenesis ERT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_100832</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERT1/acuK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617297.1">
        <property type="nucleotide sequence ID" value="XM_066755396.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987690"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="13">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="14">
        <location>
            <begin position="490"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="315"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="315"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0256020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="612" mass="66383" checksum="8A1A66FBA9DC0BF5" modified="2025-10-08" version="1">MQEHQWVHPDGLSSAESSLSFTNGTPAHDASLFNYAPSHHHHRGSTSSGYQMINPSGLGRSSSGIYVGGMGGLTTVAPTAIPPPVAVEKPLVPVFGGDSGRGRPKSKNPKAKPQGLGTERKARKKVAKACLACQKSHLTCDEQRPCTRCVKKGMADKCVEGVRKKAKYLMEGDERLPSSMQSQASSVHSMSPQSIQQGLPTMATLSSQSAEPQMQDVWLANAIQRQNPPPNINIAPGMSINQGDVWGAQTAEITPGTYSGYSTTSGTAANNEYQMLDAMFSSLSPVFPGLNDPLDDASRQIANVTQAGSKLDLVNSSVPNSFDPQQPWINPSPSQSGNTFNPTPSGSSVQGTGISPSTYGGSEVSPHQQWGWGSIDAPGQIMLDGSGATGQQNQVDLGQVRGPGTVTALNEWRRNNKALTPQEVYRAVVRPYEYTQGYHVLMDYLTKNFEINDVLRVVRSLASFRPSLIALQMSMTEEDEVFLEKSFQRTLIELEKLISYCATPTAVWRRTGEVCYANPEFCELVGKTDNELLSKKTYIYQLFDKSSVVSYWEGFSTHAFENTTQNFFQPISLALNAGGVNSCTCCFTIRRDVFDLPSVVIGQFLSIPAETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C7V7</accession>
    <name>A0ABR3C7V7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-aminobutyrate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616856.1">
        <property type="nucleotide sequence ID" value="XM_066754955.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987242"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="417" mass="46313" checksum="4FF117A58FBE5E24" modified="2025-10-08" version="1">MLTRSLQSTVHTFARRRYAAASIAAAARLVPGQPQKPTVVTTTIPGPKGKELSAAIGKFQDPRAHTLVADYNKSCGNYLVDADGNVLLDMFAQIGRDGSSATEGALKASFLSYQAKRRGNRPFSDEEVETVLENQSPGSPELSVLSFKGGFHGRNLGSLSLTRSKPIHKLDMPAFEWPACQFPDIKYPLAQNVEHNQKAEAAALAHVEETIRVWSNKKPIVAMIIEPIQSEGGDRHASADYFRKLRRIAKKHDIFFIVDEVQTGVGATGSFWAHDKWELEEPADFVTFSKKAQASGFYHNLSTRAPFAYQAYNTWMVIERDGLIKNVTLVGDYIYESLEQYEASGKILNLRGKGQGTFIAFDLPSPKERDEFIAQMRLQGVNLGACGSQSVRLRPMLVFEQSHADLFLEKLRNVFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHP3</accession>
    <name>A0ABR3BHP3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610729.1">
        <property type="nucleotide sequence ID" value="XM_066761189.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993623"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="239"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="379" mass="41665" checksum="468BC23AC101FBB8" modified="2025-10-08" version="1">MGFFSFFSKSSPPDYETLLSRLATDIAEAKTNLSEIRLRERRIALLVYLYGFAGWALWVGLWWVQGLGIIGAAQDELLGRIIGLVGVLGGPVIIYFFNRLVHLFFSRQRVHEEKHLRKLLTEQRTQLEEIKKATNYDSTRKLIERYDDSTSNRGPTVGGGPKTPQKPEQGTPNPSPKVIGPGGTPRAPGHLIGAGGTPGSLRLETPLPVPAGISPDQAAALQVQMGAIQPILPTPEKRWYDRLADSILGDDPSQATQNKYALVCEKCFRHNGLVGGKYEWERMKWICPNCNYLNPAPLSRLSSSSSAPQLVTPSHPSKSQSPSHVTPSHVLRSSASPTAPRARRPPSGEKGTPRTSKLAQEVFNASDEEAEEEMDVDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHS8</accession>
    <name>A0ABR3BHS8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610757.1">
        <property type="nucleotide sequence ID" value="XM_066761217.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993652"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="646"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="855" mass="94881" checksum="868D113927C4D7A5" modified="2025-10-08" version="1">MATQLAMDCTDFHFSQWSKQQDSGAVPPTDGWDPNDILDTELFGPSSTPMASSSSEQAPLTSSSNGLPLNKSESNGSDDALFHSYILQSMGMLGGIGEIGQLLETERVFSGEGTLPASAIHPPEHAVVADGSTSSQKPAPGPGEPPLRRGMACMFCRRRKLRCSGEKPTCASCIKHNQSCEYRTTEKLSKVPSRKNETDEGNYNLNYHYSQRPVTNYSAPLPPETGFLPYAFERHDQPGFDPAPFNTSSGASFSGLFSSASEIFPASQTIEPCPSSFANTNHPSQSSSPGSVRFFPEMEEEDPVECLTERFGEFLFNQKESPDTSQAQDTSTQSEGSEWQKKRKTGKDGRWVADGKATSESAGRAGVLQTTVESDGLSDENRNALVEFFLSNPHKFFDINIPRFRYRMSLTDKRRPALALLNAMYLWAVRLSDLPNSATVERHFFAKACQHLGSAAASDDQLLDTIRAAALLSIYMYTRSRYHEGWLVAGVAARLVLSSGIHQIPSLTFQPSLPEDPLLRNRVHLLSPPRDPTELGERVQAFWIVFIVERSGALATGFPSTIRDEDILTPFAKPLSDISSQNVTLHDDVTITDMYQDADDSNPEPISIPHTQWIRALIILERASKLAFLKPSRDSDYTKAWAEYTNARRSSSSQTSPPSPPPQHLNQPKHTNPREYRECLLALNNLRKSLGVDGISPLERKRMADAIGAQLDIPHNIIHLHHNMAATELLLHDVNCTDVDNSEAMKAARQSVDLIRCLPQTTYFRFDGEISVVWCIIAKCMIKELGRLKRKGDDDACELISEDVDVIINELHHVGDALHMSRTQATAMEELKRVALSEVDEWTEKVPRRRYVPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHU7</accession>
    <name>A0ABR3BHU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610791.1">
        <property type="nucleotide sequence ID" value="XM_066760966.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993396"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046184953" description="FAS1 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="24954" checksum="64D4AFC52AF2CEDA" modified="2025-10-08" version="1">MLGPKLRTITAGFLLLATVGSSTFAMLQPEAYNRSFTPSGSVSSGEDKSQVSFSGDGDKVRGDGNAGALASEEGSLVDIILGSGGSHDHGVIDGGDATTGPTVADMLTTERTASLWWSYARDSVEIARRLESKLKSSTVLVPVDKAILALERKPHQSPGETPEDAAFKFISAHIIDGTPREGTLPTLLPNFSVELVKDENAKGGWRVRPGDVEVLAKKDGANGRVMYLAEVLPFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHU9</accession>
    <name>A0ABR3BHU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610790.1">
        <property type="nucleotide sequence ID" value="XM_066760965.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993395"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="66"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="272" mass="31115" checksum="231396BFDE405368" modified="2025-10-08" version="1">MSQTISHEDVSRILFHLHLPPSDLLPLPPLQFLQAYLHLLPPSLLEPFAIIPPKTRTIIPSIKRRRLIHSTTHPSFLTASQGRLRWPLLWERMGGDPFAPVSESAEEEAAWAESSFMKGTAGNQQVRKLGGFLRLMEEEREAEEVRAAKRMERRLDQEGEEFEEESDEEERDAANQRPQVAEDQQEVELAFEKRLLELFLDGLDTIDYSPIDFVDPPGGDPIAQRDDEDRYFDDEEPSRTPNGTTQGDALRDRQTMDDGDKTAQNGQGEYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHW6</accession>
    <name>A0ABR3BHW6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610807.1">
        <property type="nucleotide sequence ID" value="XM_066760982.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993413"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34766" checksum="AE468CEAED75A70E" modified="2025-10-08" version="1">MTKAASLTYLEASTPLEEIHKIIERDGGVIIRNFLSPGLLQEAMRSIEPHFAVRGNYESKSTHQELGEDFFPSGSLRIYGLLGKIPEVITKIVRLPIWQGVMARFLNDEYSSYTGEKLIPQKSGYMLASTAALRLVPGAQKQPLHRDQIAYQVRPDPTNPLFTPMVGCLIAGSKCTKKNGATAVIPGSHLWGPDRAPKVEECTHAEMEAGDALFTLGSCYHGAGENQCEKTDPDALRTLFAVFGQRDYFRQDQEEVLSTPLELARTFPEDILRIAGYYKAIGGVGYVEDHQDPVEFLKAGSNLGQFAPLVSKSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI66</accession>
    <name>A0ABR3BI66_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610894.1">
        <property type="nucleotide sequence ID" value="XM_066761069.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993501"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="707" mass="76994" checksum="0D44457231F59FA3" modified="2025-10-08" version="1">MTTCHSGKLMLNHQFNNGQSIQDGGHGNFVRRDTLKRPYSAPSEDNLKRAYKKMRGDEEASGRNSGDRAHDNLAQESDSGILKEHSENGAEQINQSKYFHPALGKGKETQQSSAGKSKDPSDMAEPEVAEIPANDGIYACRPSQHSFNSWFRYMPSGHIVTNDHTIPDGPNDSGSISKADIAGRSSFDTRAPVVRSTINSHIAMPTSDDSCTTNGSDYAGTSLVTPSIRNLIYQPGPSMRLNKDTANGLPPSEAYGYAPLYTLHLPSWLNSPGSNQQFAFGSRFGTSSTSGQDVLDSELFEAKERPQTMPASSNLMPFSSSSNTNLPSTFDRRMSFPFIFHSPTGPYLDADTQQLSLFLPSLNTSVATTASATAPPSVFGGSDDGHSLPSITIPAASWTTGLPYQYKGQGQKKTDLSKNPEKKTKAETSTFCSCPVMHAPKAGETGSGKYRMCTTRVSAKRAKVQGHTMCSYCIGRDGHVEEYVSDRMAAGNPDKLCLLYVMYREAKDKNSSRPGDNNRWQKFWELHRGELINEAEAKALLQKYKDNPVKDGEHTDTAGSSAESEFSHDLSTIVSPRPSSASTALNTALNTTTSTTNLSSVMPFRSIHSIDENRLCQQTLVGDNYIGGLVEECNVDVDEPTRVEKTFGGHGLLKGDMEEIESLSRDGRFSLTPDSLYSSGEDDASSDEGWGDEDSLFEPRYGLTSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIA8</accession>
    <name>A0ABR3BIA8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610886.1">
        <property type="nucleotide sequence ID" value="XM_066761061.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993493"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="286" mass="30401" checksum="27C07BAE9D4FE4DD" modified="2025-10-08" version="1">MNEKVFTTNLRSFNDSSIGAKQQTSQPHFAQVTSLGFSEIRPVSSHESQLSAKNAGNQDCQDGMYQGGGKVARFITPGRNAIDTSLPGFPVFHRKFGNSTIIGLFAFVGAAFLLNLYTAQARGVTKPNLVLGTVLGLGGLGQTLAGILEWASGNTYGAVLFNSYGAFWLSFYIPQFGVVAAYAENPAMLENALGLYLCVWGVVTILFIIASQRSSVALLCTLAVLTVDLFTLAAGHFTRSQKCFIAGGVMGIIVAILGAYIGLAGLLTDDFSPFRIPVGDLTPKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BID4</accession>
    <name>A0ABR3BID4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610962.1">
        <property type="nucleotide sequence ID" value="XM_066761137.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993570"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="843" mass="94338" checksum="34F9D122C3781465" modified="2025-10-08" version="1">MAVRSDQQASAEMQTGNGHENVGMRLPHTPGQQHLESVPIAATSRAPASSSSIKIAACLACRAIKGKCETPDGVGPCVRCARRRQQCERPIIHRSGRPKGSKNRHSSLERAFKVIERGVHQSPAQSRKRPRLDRDGHDNSEGSHIYDQSGLAQSPITQPATSPQQPPYRRRPESSFCPAPFDFPALDAVEPQRPSSSTASLSITPYTNQQQPVIPMSARSYDSHQSSHPGGEMTREHDDGLSNPVRLLAEAAEEIGASEQSGHFSERTIQAATTQEPILPPEYNLPETLYAMLTDGEMDPISNTSGLSPEYLAQGLEILLSDGARRKLSDEDRVFFNPPLKEVKRDIGDEYCPLALALLTPREVKAFFATFYLKLHPMLPVLDPVVHTPEFVQSRSAFLFTAICAHGASLTAGAEEATKRLRIHTQRLADQISPRGFISVEIVKAFLIWISWLPSSVPFQEERLWHETKYAINMGLELELSKPLPSDLRDLRKDPSWTACLEGISMDDWDVVERIIRSRQRLWIHLFLWDSSLNLAFGKATRFTQDHLIRDETWCFHRLATKGDAVTTACVNLRRLSVRLSDMLRLELHIRANMTSEWVAERIDEVLNPWRAFWSQHCDGSAYLELVFRHTRLWTLSYALQALTWRSGSVEALTKDTFSAALHSCELVCEQLRASRGLWGFPNTMGPMLSFEALLAIRLLPQDAGTTLAFRARLFGVLSQLSLLLEQVGTTPSHRLGTAAVYGRHLQVYIRRRVIDLCVNHHQYETGQLHGDGSDHTAASSGSQAPLMREAEASINQLFSSDWISPTDQAQANMTLDGINTLNFFDTTAGWTDDFFRLFGKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIH7</accession>
    <name>A0ABR3BIH7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610999.1">
        <property type="nucleotide sequence ID" value="XM_066760727.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993149"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="577" mass="64620" checksum="7E9BE6615C774B73" modified="2025-10-08" version="1">MSPFSDDEDSREDEGPPELIFPPFPKLPSGASLIPFSESEVKGAWIPPFSANREEGDKNFATPHDHQGLPLVEMERPYTGLNHTFEERERHKKMKRRAANDRKKENPNATQTTRSRTKKPSESRLREEDCWKIGDPSSGWHEPASTSNTRFEISSPPFSRLIHATADFIRSRDAELQYKYNKRLFDIILDLFGIRTSFIGRHWPGSGPNATIYASGRMRYKTGLAPVLLPSQRYGQYGNRPPRLEETCVLLREPENSVRQFLTFTRKEVETAWEFEPALKLATMTAAFISFLAHHNVFPEPVLHSAFKKAAAIARTGPGKLIRARELESILVRGTRWNRGCWAVWGGSHSGPEPGGPEKESHWNSLSTELQASKVEIESENPDEAENGGSDDAKTGDSDEAGGWTVDEILDKRLDPPTKEDAINAVQSLIQPFSVDDIQLIQNIEFSSRAIIAVLPPQPAETGAPAYISKCHRFVTIKSPLQPTFKKSLPIQANHDNAEDEDVEDEIDKGQSVPEPEEMVIWIEAEDLADKGGGMGYVGMSLQGRWGLMGLKEDKDKSAQCGQWWAFKASDFVLPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIJ2</accession>
    <name>A0ABR3BIJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_106307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611012.1">
        <property type="nucleotide sequence ID" value="XM_066760740.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993162"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="9">
        <location>
            <begin position="170"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="561"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="634"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="473"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0240513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="666" mass="76092" checksum="5BF5247622A730DC" modified="2025-10-08" version="1">MSSVAGLQRITPVPTSADFIDVVLNATMRKTPTVIHKNFKISRIRNFYMRKVKFTQDTFDEKLGKIISEFPVLDNLHPFLSSLLNVLYDKNHYKLALGQINTARHLISQVAKDYVRLLKFGDSLYRCKQLKKAALGRMATIMRRQKDPLAYLEQVRQHISRLPAIDPNTRTLLICGYPNVGKSSFVNKVTRADVDVQPYAFTTKSLFVGHMDYKYLRWQVIDTPGVLDHPLEEMNTIEMQSITALAHLRSAVLYFMDLSEQCGYTIEAQCKLFHSIKPLFQNKPTILVINKIDIVRLADLSEENRSYVDTIIADKSVTVVEASTYTEEGIMNVRNTACDALLAHRVEQKLQGSRIEMVANKIHVAIPQKRDDVERKPFIPETVAHKVKYDKDDPSRPKTERDYEQELDHSGMGVYSVDMKKGYILADDSWKYDVIPEFLNGKNVADFIDPDILEKLDALEREEEALEAQGFYASEEEEMLDSDEEEFRDAARQIRAKKAAIKKMSQEKNTLQNRPIIPKNKKKLYLSDLTSNMRKAGHDPRELEKRAARLAKENDKINAERKKAMAAQQAAEEQAGGMDVDMDEGDAPSKNKKRAVAAVDRAPRTKRQYAGLATNQQSDKANELRMFAQRLPNRLAKASESDRHVPITRPKWMLSGKRKSGTNDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIS0</accession>
    <name>A0ABR3BIS0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611089.1">
        <property type="nucleotide sequence ID" value="XM_066760817.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993243"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="75"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="441" mass="47874" checksum="39F20DF522DE8D62" modified="2025-10-08" version="1">MMQYYSNPQMNAVMQGGMGMGMGANQGMMGQNPMLGMQGMASYGQAWRNLGYDYTPPSLAYKPETTWGAWDLAKAQYNGGRLERSFFDNIISTLTNFFANHHLSEDSARDAHRRVYYQGEGADAGNKTLGGAAAYQAYLIWDRDHYSAYHAMPSQENRERLVGLAVAELFSLWDRAQPRSTRATTDEAAQYAAATAKYLFDRHYDLPHNPHTYHRTGSRFSNYRGDDSDSEDELHLRRRSMYGQPYTGMQAAPGLGAGGMMNGMSWMNGMNGMNGMNGMNGMNGMNGMNGMNGMNGMMPGGMPGQGMGMGMGMQPGMMGGMQGMGMGQMGMPGMQGMGPMGGMGMQPGMMGQMGQMGIGEMGMGQMRGMGMMQPGMMGLQQGVPPHGSIGESQTAPGMHPSHYGVQSGVAWGNQPFDQVGNPTFLGGPQRSWYGYGQPRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJH8</accession>
    <name>A0ABR3BJH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611329.1">
        <property type="nucleotide sequence ID" value="XM_066760568.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992976"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0241947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="110" mass="11935" checksum="81D780C28B7A5ECB" modified="2025-10-08" version="1">MVNTKAQFDKAVAIVKGLPEDGPVKPTQEDKLAFYAHFKQANEGDVSGPAPGMFDFVGKAKYNAWKKISGMSKEDAMAKYVELLTEMLKKSDDEASKQYLAELEAAGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJL8</accession>
    <name>A0ABR3BJL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Target of rapamycin complex subunit LST8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611361.1">
        <property type="nucleotide sequence ID" value="XM_066760600.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993008"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0241979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33385" checksum="E2E17B371418DD68" modified="2025-10-08" version="1">MAPAPTQTQAPESQGYNSDAAAQAQTAEMSVILCTAGYDHTIRFWEAWSGICYRQITLSPQWKQVNRLAISPNKAYVAAAGNSTVRIWDIQSLSNTPIATLEGHTGNVVALAYSALGKWIVTGSEDGTVKVWDTRTAQTQRIYLHDCPVNDVVPDEDVPIRSVSISSDGNTLVAANDSGMVYVWRIIPVPNANANLVPVTSFRAHTKYITRCLLSPDTKYLATCSADHTVKIWSTAGIDYTLEKTLAGHQRWVWDAAFSADSAYLVTASSDHAARLWDLSLGETVRQYDGHHRAAVCCALNDINLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJZ6</accession>
    <name>A0ABR3BJZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Minor histocompatibility antigen H13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105744</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611497.1">
        <property type="nucleotide sequence ID" value="XM_066760193.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992599"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="379"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0242115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="47894" checksum="58B93510E9DB7923" modified="2025-10-08" version="1">MPQDNAIWATYASLGVQALIPIAIGSFKSLKTPEDTRRRLRESKKGQISEEYDDEYEEPMGETLTWKESAMFPILGSVMLLGLWAVLKYFGKKWITIILGVYFGLAGMLAVQSTFSSVIAYLLRAFGISTTTYHVRISAGFRQIFHLPTTLPTMCLVPISVVLPLLYVYFDRHYILSNILALAFSIETLALLKLDSFFTAFLMLGLLLVYDIFWVFATPVMVTVAKGIDAPIKILAPKSSPFASPTDFAMLGLGDIIVPGLVIALCLRYDLHRYAVAYKGRNVTPRSKFGKPYFWCGVVSYILGLGVTIGVMHHFQRAQPALLYLSPACTLGPVLLAFARRDIKNLWTYDESSEENKKVLDDTIESTSEAAIKARAEAKAAAEGTVSEGEATVGEAQDAREQKGQVEDDKWMDNTGVIAPEGKAKKKKGGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK86</accession>
    <name>A0ABR3BK86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611218.1">
        <property type="nucleotide sequence ID" value="XM_066760457.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992863"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF27">
        <property type="entry name" value="ACL091CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045673519" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="235"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0241836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="687" mass="75581" checksum="4F909EFAE7873DE5" modified="2025-10-08" version="1">MMSKLAVLAAVLGLVGPTTAEQITLGPTAYAAPGAFPTSFFSEYYNDPTQTVSQVQPKISDSVLNKTYPPELTDPDTIPTNDTADPLYYPPTRLHGSAASNLYQNVTDQIKNIVADDTSSNCSKCINSLTVASSLAKGAPELVPHLLVSLCNYYGFASEAGCNVYTANAQGPFYAQVLAYADVSGYDGQYLCQNFITKSECKRPPLPTFNSSDFWTKPKPTNAKPPVPKGTDRIKVLHMSDFHIDPRYATGSEGNCTSGLCCRRGNPVESLNSNYTASVPAPRYGYFLCDTPWALGAAAIEAIPVLTGTDENDAFNMTIFTGDMVSHDPYYELSRDYIEHAETALYNLWKQTLNPSSPLYAAIGNHDSYQQAFDAPSSLPGKLRKQSSWNYEHLAGLWESEGWIDGEVAQKVKTHYGAYSIQHATNLKVITINTDLWYRANIFAYINSTHPDNFGFLKFLAEELQEAEDNNSRAYIVGHVLSGYDGTNPLPGPTDIFYQIIDRYSHVIAGLFWGHTHEDQHMIYYANNGTKMSAETAQNVGWVGPSITPLTDLNSGFRLYEVDAETWDILDAHTWYSNVSTYSSLDGQLEVGPSYVYEYDTRQAYGGNISWPDNAPLNATWWHLVSEEMENDGGALVQLYNAHQGKMSTLSPNCTSTQCIEAKVCYLRSGSGPLALDNCPTGYGSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKG1</accession>
    <name>A0ABR3BKG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">I308_105898</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">IND107</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611651.1">
        <property type="nucleotide sequence ID" value="XM_066760347.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992753"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="287"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAL0242269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="344" mass="38070" checksum="34E3CF224F0B78D1" modified="2025-10-08" version="1">MDAPVASSSSHYPQPLPPSPYADLSFEPASQAQILRSHQRDTAQIHRLTELASEIARSLAGTRWLAQKQILVDLLVKAVYLSLTLGRGSQTLGEEYTDILPYSPRRRSSPSKTRRFLTIMFLLFPTVLVSPASTSYIRTGGHSQPSSRWRIAVEKIGEFLSSPLGKAIPELHMIVFLFRGRFFELGRRLTGMSYISALPPTPPEQRPESYEPLGLLLLIPFIHRLSGPWLSARAELPQPSSHETWIGDTIHSGKVAESAPIIDADTSYDSPKTYLTQEALDLPERQCTLCLEPRGTGEGSGGTVAVTECGHVFCWGCLGGLEKLECPLCRQSLRMERLIAAYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKI0</accession>
    <name>A0ABR3BKI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611305.1">
        <property type="nucleotide sequence ID" value="XM_066760544.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992952"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0241923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="40852" checksum="2FE192A6C42FA617" modified="2025-10-08" version="1">MGWIQAGLVSTAESIALGLLSFPSIFLRLGMVGGVITTVGPGILAHFTAWIMVDFKLKHPGTNSWYRSSSQTWSHALIGKQALSILSSNAICSVWYALIVCIASVLMSVSREFGKLSLMSFISISSILVVSGITIITTGIQDSSVLVRNGVPIAWHAVPTNPTLVDVIGGLTNVFFAYGVFHHRPRILSYTVVGATIYAFGGQYVTSPALTMTTRPVRITAYSIALVTIMISGIIAVNVGAKCLYIVVFRRKDLLTSPSIKARLSWVGLVAFMWTVGFIIAELIPFFNQLLTIISSLFSVWFTFGLCGVMWFYDIHPLFAKNDESRTLDTPMKKFLYICSIIAIVLSVATGPLGLYSAAESIKAGYSAGSFSHPFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKM9</accession>
    <name>A0ABR3BKM9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein IVY1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611721.1">
        <property type="nucleotide sequence ID" value="XM_066760417.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992823"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037470">
        <property type="entry name" value="IVY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407:SF1">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="46554" checksum="C1D3F5CE00E67B7A" modified="2025-10-08" version="1">MSTSRPRIDSIRSSSTIDHSAWGARAPSPSFSTTTTGSKVNLPENHALITRKDLRQSIACFEELMAAAKAYRNALLAMSSATAAFATAMEACSRVKGCRSSNSALAGAGGLQYLVSNHEQLLADTVYRQFEIPLLHALDNYKMITADRLAAYEKALHEQSQKIRKTEAENLKIGRRRKRDLQQFRQALGELQRQVDELDSIKAAYHEEVLEGEEEVWETVLGRVAFVIRSQLDFYEKIAGKASDPILEPMVMSIPDPFDAYGPPKEEGQIFSVLAPLSLLDSSAPQSPTLNLPRVLSPPPMSAKTTSPGRPSSPSDFHGTPTRRSSAPREPDASSESVFGQHDTWLESASGTFGTSSVSELGNGSDRSRRELSIIDEGDITLNGKKNNQNEGSDDGDDDGDGDEASVKAVKNSLGGKIDGRPIKAANGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL40</accession>
    <name>A0ABR3BL40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105483</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611884.1">
        <property type="nucleotide sequence ID" value="XM_066759938.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992338"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0243517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="296" mass="31578" checksum="FE11693204E6CCA0" modified="2025-10-08" version="1">MPFPAVDLKQKAANLPNAPVSTFIPPTQPVTAGKQLPTSVPLPVLPAVEAAKRLAAYAAVDRHVAVEHKVIGVGSGSTVPYVVDRILAQGFEANKDRVFLPTGFQSKELIVKAGLTLGDVDQYARIDVTIDGADEVDNALNSIKGGGACQLREKVLAEAADTWIIVADYRKNSEILGTTWTKGIPIEVVPFAYAKVLTNLAHMGSPHVLPNGQPGLSLRMAKMKAGPVVTDNGNFIIDAPFSEEQMRKPEELLYKIKMLTGVVEVGLFCGMAKAAYFGNEDGSVTIRSDDGTVSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLB0</accession>
    <name>A0ABR3BLB0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611578.1">
        <property type="nucleotide sequence ID" value="XM_066760274.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992680"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="409" mass="44950" checksum="1049EE5CCB741E5B" modified="2025-10-08" version="1">MPLPSVGPNKRPAPITSSAFAFSLGTPKQKRPKANGKITPSSVNPPPPPSPNSQQKARNESGQRDAATLQTPFRRQNEHHGTSSKETSAYKARATTPSINPNRDLTSNVRQYLSPASLKVARRTAGGSSKLQPMSLHTPSRRSHEQESASKPKSLRRVTEQLDQLPLKKEESTEAKVALQATRLSGKVTEDLAARKRTILVDDEQETGVSPNGKKITKWSGKGHTPSSLQLANLLSSSKASTHLFYTSMQNILNPSHRGPRRSRSRHEGDMDAITPIQHIRRAAPIRLKPLSCIPGPTHHCALFWCKVLKWSSSELTQFHGQGEKVLVVLQPFTADAPRMGVDPQLMMARMKDDNNTKNWLVGIWLCSEIPLPIYGQDTEEGRGMLAGAASKSNFCAVFGTRYLIAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLJ3</accession>
    <name>A0ABR3BLJ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_106429</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for protein translocation in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611130.1">
        <property type="nucleotide sequence ID" value="XM_066760858.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993284"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006398">
        <property type="entry name" value="Sec61_beta_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0240631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="100" mass="10432" checksum="99F80B842F05A867" modified="2025-10-08" version="1">MADTKRPTSPSTPGQSSSFAVARPHGANAVRRRAPAAARPTSTRAAGAGGSSNTMLKLYTDSGEAGLKVDPFVVIVLSISFIASIFFLHITAKIIRAFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLL2</accession>
    <name>A0ABR3BLL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cns1/TTC4 wheel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611710.1">
        <property type="nucleotide sequence ID" value="XM_066760406.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992812"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="5">
        <location>
            <begin position="288"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0242328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="423" mass="47209" checksum="E750E06929391EC4" modified="2025-10-08" version="1">MAAQAASTAGAQSDDGFLDQLIAAMPKSTIPPESGVGPAAPKKEVTVEDFEKLLDSTPLFMRETPKDGDDNPVLEALRSLVFEGEGDEIATNFKNHGNELHAQKSYSEAIKAYSEGIDAHPSSATLLVTLYNNRAACHIILKNYRSALKDTSAVIALYTAGKIPQPDKALAKALFRAAQSLVQLSRWKEAGDVVERGKELAEQVKEDTKVWDTLEKEVIKGKKRDDDRIERIRRENMTKLALRKAVEDRGLIVVDTASPPDNPNPLHFDEQSIPIIDEEAGWTPPPPHTPIVFPVFLLYPTYGQSDFITHFHEDAAFEDQLSAMFPVSPSAPQIPWTEWDEKHEYYVPNLVVYVETNERRLLKVGKELTLREVLGKAMRAANGEVKKDGVVLRDGLLSFVVLVKGAQEKAWIEEFKRQRDEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLP6</accession>
    <name>A0ABR3BLP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612087.1">
        <property type="nucleotide sequence ID" value="XM_066760141.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992546"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047128">
        <property type="entry name" value="PhyH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308">
        <property type="entry name" value="PHYTANOYL-COA ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308:SF8">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G09620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="41707" checksum="AC9C2E33ED7963B0" modified="2025-10-08" version="1">MRAYLPKLVSQNSVRSRSWTPSRPLSGLPPAVGSQFSPVGLRVQPRSRLMDPFSSEELNRFTQICGQATEHSDYPLSSEIAHNAVVYSGDRLRHLIASGNQSRDDIMAEIHRCLATGPGVLVIRKFVKDLDLIQRTNEAWLGPGYQLTAQVNVVRPGGKAQQPHRDYHLGFQSERTASRFPIISQIASAMLTLQGAVAHTPMPLASGPTQLLPFSQQFDHGYIAYRQPEFVDFFHKHMVQAALDTGDALFFNPALFHAAGDNNTKDLHRMGNLLQVSACWSKPMETVDRNAIIRATWPDVKDYIANTQGGLDSPSSQALLKAICDGYSFPTNLDKDPPPADSHCPETQLDRVTRGVAEKWSGDTLNQALDELAAKRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLR0</accession>
    <name>A0ABR3BLR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Catalase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_106630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610878.1">
        <property type="nucleotide sequence ID" value="XM_066761053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993485"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF26">
        <property type="entry name" value="CATALASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="8">
        <location>
            <begin position="9"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0240379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="498" mass="55930" checksum="EABEF98E0C37C487" modified="2025-10-08" version="1">MAEKIPIYTLSEGCPIADATTAQRLGSCPVKGLMLLQDTQLIETLAHFSRERIPARTVHASAVGAWGEFEVTHDNSDITSAAFLNGIGKKSKVLMRISTVGPDAGTAETVRDVRGWSMKIFTEEGNQDFVFNSIPVFFIRDPIKFPSVNRSHKRHPAKHTADSSMFWDFHNNNPEGIHAVMMLFSNRGLPYSLRQINAYSGHTYKLTKSDGSFVYVKLHFKSNQGVRGMTQAEGVRMAGESPDFHTIDMWDAIERGDYPTWTLCAQVMKPEEAENYRWNIFDMTKVWPHKDFPLRPLGKLTLNRNPENYFSDIEQAAFSPSTMVPGIAPSGDPMLQARMFAYPDAARYRLGVNYQQLPCNRPVSEVYAPYQRDGAMRYMTNYGDDPNYVRSSLKEINFKGQLGANGHSTGGNEKHNEWVGRVGAYTSEVTDEDFVQARMFWEVLGKSGDQEDLIISVSDHLSKANPSLQKGAINMFAKVNVDLAKSIEDRLTELNKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM00</accession>
    <name>A0ABR3BM00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612186.1">
        <property type="nucleotide sequence ID" value="XM_066759539.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991937"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="660"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0243819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="756" mass="82075" checksum="52C426F8A80A0CB9" modified="2025-10-08" version="1">MDDSQAGPSLTAYASRFLANRMGDRGREVQGSQIFRSPSPSSPTHNPFIPSPSVNASHPHLAGSRSPSRSPTRTPPFPGAGIDDIPDIDGTVGASSVGVGLLFDGPEDDYQAKPQESLIQPAVEFGGNKGKERSRIPNPYESSSDSEDEDEGEPEMGLDEVDTVRRSLLRPHPQQQRKPLSERAKKGWLAHQSVFPPSSSSSSENESEKETESESGDGESRVMNGGRGESYEAGADSANLYGTQTIPAAYNVITNLEEPLLAEEDGRREARVPVRLHVYHGRFGHWEKEGLRKYKDSGFLALWLASLIGIIIGLLFVWGSTDPPPDAPHSPPSILPLLPLLFILLIPPLVLPPAFLFLLQKTVRPVLMATAVSIPFSLFVCGWWALGASFETTGLDGVEQGDKWWGTTGLRVGALLLWTLAGWFGRLVWLRRKRLEKTASVVELSTKLLLSHPPLLLLTPILLGVFAITSIPFLTLLIRLGMIGYWRHPRENTWVFHIRPYAGWLIFLVTLIWVWTWGVIRGVGRVAVAGVIGEWYFHREEHSRQDPVEVTTAAVHRATGSSLGSICLGAGIIAVVRTVGRAASTLKQYTSPKSTRLPSFLSFLHHLAPVFTVIAGVLDQLNGYALVCVGITGDAFWPSARRAVGLAGRRRVGKLLDYTLIKLLLTLSSTAMGLFTAMAGYLYMAHSMGNPGYAPLAGMLCGGVPFLAVRAGAGVLTDAADALFICYQIDRELGGQHSEEAKGAFLGVQPRGARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM44</accession>
    <name>A0ABR3BM44_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612229.1">
        <property type="nucleotide sequence ID" value="XM_066759582.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991981"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="471" mass="52900" checksum="788C2EA1F5C6D882" modified="2025-10-08" version="1">MLVPSKARQALCLASIHARYLSRSNSSAHQCPCGCSKFQPGLSSFLSRRQLSSVAFQNGRAVTLEQNARYAGPKRRYASVSLSKWATETEETHTKLIEAAEARVNVYKKVMEDEAKATDVDVKGQIERARVQKELAPLVEVWNRYLWLKQSIIDMKPFLEDSDPALREMFETEHASLCTELDTLIISTFPTVLLPPSSTASLPVVMSLNAGVGGLESALCTEDLARMYLRFATNRGWKVEEISRVEGTGGKGGGGIREMTVKFEAPQYAEEGMEVYGALQWEKGVHRIQRVPANETQGRIHTSTVAVIVLPMYPDTAEAPLVDPKDVRIDVMRARGAGGQHVNRTESAVRLTHMPTGITVSMQDSRSQHQNRTWAWEILRARLSEKKHNEEVEARRASRRDQVKGADRSDKIRTYNFNQDRLTDHRFGITLTGLQRVLDGEGLEDVIAMMKKDVDERRLEALLEGEEDLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMP9</accession>
    <name>A0ABR3BMP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612426.1">
        <property type="nucleotide sequence ID" value="XM_066759779.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992178"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="560"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="608"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="536"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0244059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="638" mass="67210" checksum="2C1744C2B3E73AF7" modified="2025-10-08" version="1">MPFPAIGRVGLAGAPHQGTVKRTVQERASCDLPAGELYVFPNSTTVIDATSPVTFKWNTACAVATSTVDLYLYESAGLIKAWPDVDFSAGEYTVQLQPKWWNDTTTASLQMSILDHGADLWDTSSPAGPVFTVNYAASAMVSTTTSNGQVITSTVAAAATESKDAVFHNVSSTNNGDKSSISKGAIAAAVVVPIVVVALIIAVAVRFWRMREAEKRKRWSQALSTHSNLEWEKGAMPGEKPPSVLGRPSMGGRLSMGTRPSMSSYGGNPRPTSSIYAIENNMAGAGAGSGMQFRPDMHPEMSSLRSKSADNLSAAGRGSVVMPDGQVRQSRISFAEQARPDRVSRASFGGDIRPNVTSSSIFRLPGASKSANDLVISTNRRSAAYATGSALDDEEHISISPSQQDGPLGFAEADLRRVAQGQRTGRKSLLSLGSGRDNKRQSVASALSGDDFRSAASARGSVDELRDMENMVLHRRSMMSQASPSPNFEAAYSADAVESLQDPEPVSMPLPSPIPAGQDPDQALAMYAAQRANAMSPTNNNSPPNPSRSNSTMKIPFFSKKSASSSNSSASAPGAGANPEQGEVPTMGPPVEMRSYVHLNSGTVSADVVNALPKPGPPAATRVSGASEVSKYSEEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMT6</accession>
    <name>A0ABR3BMT6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612469.1">
        <property type="nucleotide sequence ID" value="XM_066758982.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991364"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0245385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="537" mass="59484" checksum="A85A7C12817D4D1A" modified="2025-10-08" version="1">MSAFMDEKASIDHIEDGEILDRKDGHHHLTQQEMKHGDKALQYIGEERIEVTVEDDKRIRRLTDKYILSLLVWVYFLQILDKTILGYANTFGMSSDTHLVKNEYSLLGSVNAIVQLAWQPFSSYLIVKVPARYLMPAMVFGWGAAQACMAAAHNFGGLMVSRALLGLFEAGCLPLFSLLTAQWYRRSEQPVRVAAWYSTNGLATIVAAILSFGLSHISSPHIKVWQLIFIICGGITCLTAPIIYFFIDADVPSARFLSEEDKAKGIERLRANQTGTGTNEFKLSHVWELFYDVKSYLFLALALLLNVGASVTTIFGPTLIKGFGFNSRITSLLNMPFGFLQFLAILAGCYAAYKFKLKSAVLATFVIPVIVGLVLLYVENSAAVLKQGPALVGYYLLAFLYGANPIIVSWIVANTGGQTKKALLMSVYNAGSAAGNIIGPLLFQDKDKPHYLPGIKSTLGIFCALLACIGFTTAALFLLNKQRQRQRVAVGKPQYIKDTSMSTKYEAYGNDDAEHRLGQNALLDLTDFKNDEFVYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMV7</accession>
    <name>A0ABR3BMV7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_104524</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the NSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 15"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612485.1">
        <property type="nucleotide sequence ID" value="XM_066758998.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991380"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosomes element 1 RING C4HC3-type" evidence="17">
        <location>
            <begin position="208"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="268"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0245401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="351" mass="39287" checksum="155E31E4C4D0CC71" modified="2025-10-08" version="1">MSRDAVANVEGTVEPTLLHRVFIQSLLSRRVVSETIALELYKRAVAAVRAHNRQFNPPYATTSHGVASFVTDVSSLLHIVSLEVIRTIDQRSDRAFFVLRNLDASEVASLATDLNSMEVEYLRNLIESIVISYPANSLAIGQARDVINDSPLTQHKMTKSHAESLLDALVSRGWLYKSKRIRFSLGVRALAELETYLKNEFDQYVKSCAQCKRVVTEGIACSNEGCDCHIHNSCYARNIQRLANPICPSCSSSFRDLVPKPIGEKAVSTMEDSFKGGRKRKGKGKNVRNGDEEDEEEEGGSSEAEDELDEQRENQSQVQNQESIRLSYVPETQYEEEPSTSAGPSKRTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN06</accession>
    <name>A0ABR3BN06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612531.1">
        <property type="nucleotide sequence ID" value="XM_066759044.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991429"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="367" mass="41402" checksum="0146C977FCCB2B33" modified="2025-10-08" version="1">MESDTLGFKCAHPGCEKSFTRKDHLLRHAANHSQTSYNCPICRREFKRYDLLQRHEKRNICGDDPTGSNPFKRPRSESSSQEESSVQHAPPAPPMNPMTGQLPDSSSFQTAIFPVASNNTAMPTNGTYDGSLQVPNSSNPHVSDFSVEDIMGDWGFSLWAPEQWEALLHETLAPPFNEPMVDMPWDMPMLPRMQQQESAERGHDNVASVMLVARLQRSYPEFDVPLSWVVEALQTYWTRTAPTFPFIHRGTFDLDAAPTELVLMMTIVGSVHMAPRRDFSHLVQKIRGVLVQGCGLDMPISTLQTFCLCHVHDTWYSTADSQFVAQCMWPVMVAHSRKKGIGVVGKPENEIHQEEAWAAWAKEEGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNF3</accession>
    <name>A0ABR3BNF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612680.1">
        <property type="nucleotide sequence ID" value="XM_066759193.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991586"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046894182" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0245596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="182" mass="18424" checksum="3AABE17010845B95" modified="2025-10-08" version="1">MVARSILALASAAAVAQGILITAPSNSSGWNTHGSQLIQWTSVITDAHNFTIAISKPNSSSRTNIITTLVNTTDESYIYMPSSDLEAGDGYRISFTSPDGGILAQSDEFSITNGTSTVSATASANSSATSSLRTSSGVTVTLADVSHTSKAATATQSSGAERLTSFASGLLMLAGGALAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP15</accession>
    <name>A0ABR3BP15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612000.1">
        <property type="nucleotide sequence ID" value="XM_066760054.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992455"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75704">
        <property type="entry name" value="Mitotic arrest deficient-like 1, Mad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="220"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="330"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0243633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="675" mass="75843" checksum="80A98BF60709E029" modified="2025-10-08" version="1">MPATPAPTLGKRSSADAELHTPSSRKHLSTLTSTVTSLERINHTLQQRESRLAAQVEEQRLEIERLKNERYELFEAKMEERRKGEQAEQLWAEDRLVLTGEVALLRERNLALTNGLEELRSQHTVLSTRHASLAQSSENEISLLQARTAELERERNSLKTWENKAKSLSIELEEERARKATEDGERKTDDALQKEVKRQSANLAAVWRENEALKSEVHTLRHEKKSIDGVERAAKEVERALHEEIRVLQEQLERARRDMDSLTQTLPDPASTEPSEIATLRTRLSTLSTLHSQTTTSLVQRESTIRDLRARLADLAASSKDAVGEMSQRATEAERELRWAKEGRESAERRERLVRKELEAVRRQLAAAPGSFAGSSDPERVKELESLVQSYKTTLEEIHRDSRDAEVRIAKGMGLVKSQDLDKAQEKISQLEEEIAGLSSSVSDLTSSNTALTAEVTNLMQRIASGEFNPAYERCLELRNNPARKIWGIRKQELEDLKAENGELLERLAELDGLLAGSQAGAGVSAGGGAVPVREGMVPSSSYDRLKAEKEELEKAHAKRLQRLKEIFTHKSKEFLEAVYSLLGWRIKFDESGSDIRLTSMYAPKGKNGLTIKFTSSEGHFGTMQMSGMMARSLEESRQFWVVERQSVPGFLAQVTTEMFEKTTIGRAAGYVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP58</accession>
    <name>A0ABR3BP58_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611763.1">
        <property type="nucleotide sequence ID" value="XM_066759817.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992216"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="3">
        <location>
            <begin position="1417"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="4">
        <location>
            <begin position="1576"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1387"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1392"/>
            <end position="1405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1709" mass="185089" checksum="FD448C66E3EA6024" modified="2025-10-08" version="1">MSSHTPLSAIADPFSLAKLQVLLVPVHAHAPISKSTFHHYTHVIKGHQTLRTDELVPPFHPELHRDGGPNPRLRFFPHLTSPGGYGGYGRNGGGGGSGHQVHLTYTHSPPANHLYPLSLFRISEFPLVVIGVAVDGEEDTFSRTQEHQEVEGYKLSDEEMEGDIGEGEATPTLPTSYRSKSASSQGALKTEFDRTLSSLFPSTSPFPLVKRLVVVPNPSLGANASKERKGKGEGEVLYAPREGLEQWITKLIGEVVGDALGELGVIAASLETPSGLQTLSSTILPSLTCLPPPSSSAGTAENSYNNFFPHPRSETPSSYTSYASTPSSTTRSTPTIAGDIVGKVRCITPGGIPSSAAITARAGVTQTQLPIEFPFPIHTANPTSSSTSLSTSTSTSALSSSPINTSTTGRPSSTIGSSSSSLTNPFRRSLAVSSPFSRRREGRAVAGIEEGWGWRAGGTQTQPFPASPIPNEIFSQFVAALGCISSAPLLFPEFDAKSGSEQPQQTATDRGTHLLAYLYAGLALRSAHFLLIVWAAGGWGEVALGCLVRHELPRSFLLPILPVSSPPSSSMSRAHATATTSTYAQEGKRKSHLRVLSASSQIPRHFILSLARLATSAPILRCLQSFSFIPDSSSSGVEEVVIWREVGWIARLVGMERKEGWIGGMVVEAIVRVLNAATASKSQVSGNGSGSGPGAREGKDGNHGRVRSGTAVTNMSTNTNISTASMAGTADKEKDRRLSTMSQASLRSQTSQTTETTQASQTDTDPASASASVGLGLGMSVSISSTYPTTTSETYSQRRLGRGGITIRRKEITQGNAGIFSILSQQARVLGIDILRDVFPTERSVFVLWPPAGSGQGDGRRKDTGKGLSSGVMVGVDDELGVGFTRAGVEDFGWASLKLEFLKKSITLLGNLPDHPNTVRLALIALHLLPSLSHQLALQSGSGVDGGTQMVLSRVYMAALGVMKRRGLGVYGMYGRGELGWWVPGRVVVSLEIASLPTNKLPTRHSTTELVAETSEDNDVRGKMDGKGQAVKRDPFLYNPRTIKIGIGMGGKTSLVAKEQIEVFVTLRNPFAFPMNIKDMSIITSGVPLHTHSYEVSIPTLSIQTIRLSALAPSPGTVQIRGVSLRLSDGSVGDFYLPLLTDQECVKRERKCQKERIRCRDAKRSGMDRMTAWEEEVVVNAERLREEKQNLGSLKWLECEVLEPLPLAWIKSTSLTHGMAMLHNGETSTIQITLENTSSIPINYLRLSFEDSTVRAATRILQESELGAEEAYELDWDVRNRNVFTWENPMILVAGEGEESLIIPGGRKVLKIRCLGKVGCTEGLVRIDYGHVQSASRGLTQTDDAGLHASTTTSTSTSFYTRQITFPVLFTVTHTLECHSLDITHLGHGANKNRSPPGLNSTNGLEVQEENNGDLRKALAEVNTSTHCLVGLSVANVYGVPFEVCLASKGTKPEKGNVECRRLIPPGATERLIVPIPRKSIPQDILSQSIPSLSERQYVVDKEKKSASRIALERERFWYREALLDMLDLIWTEPGSQRHGSLILRNQILTPSLLQVFRADAIDVRVILRGRGKDGDVRAMDFVDLVVEVTNNLERPYRPYINLTCLPTSSTDYSWARQTSIYRPSPTEQRSHAHPHRNVLFDGYPAGTLAMLQKGEKDVYEVGTTFLSSGEYGFRASVEEIKGEDKEGDMVQVDRKQAWFSPILQVQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPA0</accession>
    <name>A0ABR3BPA0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612598.1">
        <property type="nucleotide sequence ID" value="XM_066759111.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991502"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="8">
        <location>
            <begin position="159"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0245514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="233" mass="26482" checksum="FC639084F581EA86" modified="2025-10-08" version="1">MPAQPVRTWTCEELLRGHATKKYALIIVNQPIRRDLLERAWQAVDIRLCADGGANRLFDVDHEKRYLPDLIKGDLDSIRPDVQAHYASLNVLIKQDKDVYATDLMKCIQEVPDDHALVLLGGLSGRVDQTVHTMSMLHKLEREIYVLDKQSMAWVLRPGQHEIQIDHSTMGQTCGILPVGIDSAHVKTKGLQWDVDWDTSLDGNLSTSNHLLPEEPVVWIETSKPILWTVEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPB2</accession>
    <name>A0ABR3BPB2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612996.1">
        <property type="nucleotide sequence ID" value="XM_066758548.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990924"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="3">
        <location>
            <begin position="34"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="211" mass="22514" checksum="2DB7C5F5BDDDFCBF" modified="2025-10-08" version="1">MSSISTTRSAAATSSRPSSSNSTSSTSTVSIPGTAAAGGITVTQPPSTASASYYKIAKDNWITFAWNMTSLYVTPTSLTIVASCSANGNTYRVGPTTSPYNVFPGNTTQVVWNPWEWEQVPTQVAFAEATYVLSIWDERGPGAARKGGYLTPYSGTNFMMYRPAGYTSIADGWQCSTCSDALYTLSQPAHLLVLTTLIVTIVSAWGILRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPI6</accession>
    <name>A0ABR3BPI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 9">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_104144</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 9"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613070.1">
        <property type="nucleotide sequence ID" value="XM_066758622.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991000"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="10">
        <location>
            <begin position="26"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="169"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0247109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="338" mass="35674" checksum="FB0E949F4D993CA7" modified="2025-10-08" version="1">MFARQVAKNSSSLARGFASSARSNRKVAVLGAAGGIGQPMSLLLKQNPGVTALSLYDIRGAPGVAADISHVNTHSTVKGFEKDDIKEALTGAEIVIIPAGVPRKPGMTRDDLFNTNASIVRDLAEACAEYCPKAFIGVIANPVNSTVPIFAEVYKKKGIFDEKRIFGITTLDVVRASRFLGEVKGKDPKDVKVTVVGGHSGVTIVPLLSQTPEGKDVSGEAYKALVHRIQFGGDEVVKAKAGTGSATLSMGYAGARFTDSLIRALNGETGVVEPTFVKSPLYESEGVEYFASNVELGPEGVKKINPVGQLSAEEQELLKACLPDLAKNIKKGVDFVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPJ7</accession>
    <name>A0ABR3BPJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104146</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613072.1">
        <property type="nucleotide sequence ID" value="XM_066758624.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991002"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0247111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="313" mass="34958" checksum="CD477E2CFF274682" modified="2025-10-08" version="1">MPVCTTCACPADYIYTTYKTKSNIRLAVCPRCNHFVDPLIEHPSLLLLLDLILLKPRVFLHLLFNRGSLPFSAVSEPVSEVEREVARRRQLWEDFSTLALLSVGAETAVRLLPTLSDPRDSSDIQPSKILWTIIAVLLEGMAQHLATLGLSMLALKLRYWNNPVSSSTDKHQTRQDGRRKFFVPILIPLTLLYTSLLPLLFQLFLFPWYTTQQTIHEQPPAPSLSLSLLSSLPLPSSVTIPPSWLDTERQISEAWARGDRIWAGTRLLGGMSAGYGLRVLLPTKPWETTLIVLAGWIAAAFVGKVIAELPLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPT6</accession>
    <name>A0ABR3BPT6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ChAPs family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613161.1">
        <property type="nucleotide sequence ID" value="XM_066758713.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991091"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="74345" checksum="8FBD2DCC61C5ACFC" modified="2025-10-08" version="1">MSELFKDIPEFVEVTRTETLGTFRELGPPDLCHVVKVYGKPPTQREIGSYHYCSGVEASTSASLAAYLNSLQFSVEDSSAWFGKGSAWKVRSGTYCCFNAFSRVDMRVEANIPGGVDAFVVDLHGQRLAGYRKLDPITTPEAEERFLKAAEALFFKGWQLGSDPEIQVATVVTNHLTSAILKYFSDSFRLDRAANLFERMMDKEPEVAALVAKSYIGMNEEIKAVRIMNAALTANPQSYPILHTQVDFLLSKHKYEWAQQVAQQAVNSAPSEFMTWAKLTETHIELGQLDQALLTLNSCPMFTYNERDLHRMPTPAKSNMPIKKFIADSNLVDEDSSRENEADIALLRLPAPNLRGTFAKAYSLLTLLVSKIGWDELLKIRSSVFVMEEEYRLHKTNVSVDMNGEAGDGASVAGLKRTSSEGVNTPSDIPTIRISSESMRTPNTASGAGFSEKPGTRKPALEKPETAQANEHPNSPLGMKSEGEQPVSAFSHKRLCERWLDNLFLVLYEDLRVYTIWRAEISHFKTQHMSYRKTGTEWEILGELASRLHHKEEAKEAYQRCLESKFSAKALMKLLETYANEGDLQKTLTAAVRLTTYHHRWYMDASYPSMVAHYLYKVGLIHGHAKIQYTMLSMNLPVGIFEIMQGYMKYGATFNVEGSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPV4</accession>
    <name>A0ABR3BPV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613190.1">
        <property type="nucleotide sequence ID" value="XM_066758742.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991120"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="188"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="350" mass="39203" checksum="0310869D6C0A3C49" modified="2025-10-08" version="1">MSFFSDTDDSPPPQPPYNRAPSAAASSFTDRLRSTISPGLSHPPLGQLISSSSSYGASGSGSRREERAISELDEEAYYRELGIGDDDEPEVPGTPTSNVFGSLSPSRNPYGVTHDGAGRRSVETGFGVGLGEGGATDWEKIDEELEIEDMDDVRKMGLVWTRERGTADIMPWEGELVDSLLDKLEQQQKMVSALRSDPQTSEEEHFKLMLVQTEMERVKYLVRSYVRTRLHKIEKFSYHITLSPELHNLLSGAELSHAQRYTELLHTHFQHSVLDSLPESFRRLDETYGDGTSMVTKPNKQIPVLIYVRKDCGEINLESGEQALLAKGTTHLVKYSLIERWINLGWVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPZ0</accession>
    <name>A0ABR3BPZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Post-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612853.1">
        <property type="nucleotide sequence ID" value="XM_066759366.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991761"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Post-SET" evidence="3">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0245769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="202" mass="22430" checksum="730BE416985E8A58" modified="2025-10-08" version="1">MPTATINPALPPEPQQAWVKPTLSNTFEGKTYQPTHPDLFRVEFTASKGLEEGYASRLVALRDFAPNELITPLTNISLAPEKAYSSVQFGTGPRDHLELNSDLLFMNHSCSPTTEVHLPPFRPNEWGVYATSKGLKKGESLEFFYPSTEWDMAQGFDCACGSDTCLGKINGAKYTSLKELQARGYINQHILALKNAQLKYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQG4</accession>
    <name>A0ABR3BQG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613385.1">
        <property type="nucleotide sequence ID" value="XM_066758937.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991316"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="147" mass="16606" checksum="F122AA6D8DA6EB4F" modified="2025-10-08" version="1">MAFTTTEAVVTYLFARPTLPPLEPGAKVYDQSLIKAIEGLDAHSYIKAALHLANDDINRCHLIAQDHEGDPTADLLHATLHRREGDYWNSKYWYSHVKSHPLVPDPSDAKAFVDACAKAKPGNDTTLKERQWTELKKLVEWTLDNCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQX5</accession>
    <name>A0ABR3BQX5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613556.1">
        <property type="nucleotide sequence ID" value="XM_066758154.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990525"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="135"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="684" mass="76040" checksum="79CB9A281F245F43" modified="2025-10-08" version="1">MGPLLSPVKSRPLSRHRSAEPLPPPPPPKAIDLNSSTRSTDKVTGRKITRRAFLCDVVVEREGEETANLLAHLGEPLKPLSTLPPPAQTMNGRPTTPSRLSQPPDSDDERENTANTGPVWTAVWTAVKRDEMKKKLTNVIEELVRTEKSYLSRIHALKSAYADRLRLYSKDPNQQLIPPYEAKAMFANIELIVPASMAFLSDLEVMMQSGHAEDLVGDVCLKHFKTLRTFDPYRTYLSKQDESQKLFQDCLKKFLGFGTFIESTKYQTTGIGNIGLRELLMEPVQRIPRYTLLWQTMIQYMSPLSTQRAKLLEAIEIASGIARCEPDAQAVRATVMYNLERNIDDFPAKLFSNNRDFIDAIDVEDIPAEYPTAQSPNGRPVSINSRVAASTGSTPSLPAFGSLPSTSAHMPQSPHSGTSAMPTLYCTLILFDDKLMIVKRQSSSISGRKITGTDDVQKLVKSGGGIAVKEKNNAKRDKLSYRGEVDILDVMASDVGNGDFHLFFERPPADQCGRWGNRSFRSYSTVHPPHPVSLDPVATKRDKLRFIQNLWAAQALARAKVLPSSEGKAIPRVLQSETEVDLEGGDLERARCFWDVWDRYGWCGQRKGKVVIHVDEDGVAPVLPVDTKTTKLSVYLQPMAGGLCRYTHCVAGKEEAERIVIEMSEVKEKIASTSKSLQKVCADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRE3</accession>
    <name>A0ABR3BRE3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_103811</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613694.1">
        <property type="nucleotide sequence ID" value="XM_066758292.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990667"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0247733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="305" mass="35077" checksum="BA572E74A173590D" modified="2025-10-08" version="1">MAGTVPQFMVDEYVLAYHGPLLYEARVILAEVWDESNTLLGTVGPHYFIHYKGWKQTWDEWVPESRLLKLNEAGFAKRRALLDAQAKKGRSTGGSGGAGSPGGGKGGLKDKKKDTKKRGRDAMESESDFMKRPEVKIVIPDVLKLVLVDDWENVTKNNQLVALPRKPNVRELLEEYRQYASASKKQERSARATALLSEIISGITLYFDKALGNNLLYRFERAQYVEQKRQNPEKPMSEIYGAEHLLRLFVNFGPFIAYTNIDTESLNILRDYINDIMQWMIKEQKRLFMKEYEETTTHYQNLSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRI5</accession>
    <name>A0ABR3BRI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103542</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613438.1">
        <property type="nucleotide sequence ID" value="XM_066758036.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990398"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="4">
        <location>
            <begin position="358"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="599" mass="66404" checksum="4DA20211EA97B5D8" modified="2025-10-08" version="1">MVKSQKRAEAASKQKPNVASQDPGAQIQKLEVSLSTGDFNPNPLLPLISFARHNDPEVVHKAVWALHRVFIRYIADGKVAGLSGDLVTPAKKPEIEGDVDAKGWVRERLLEYVEVLGGLIRDAEPALRPKQKGPGWKIVSANQCEDEAGVLPDDVAGIVSGEFWAAYDDIRWAFFKEAAQLAQTSLITPHSGNLLTLTLPLTNLPKVPADINTFYLPSFSSPPPDSNSTATMKKSRSVRAKKGKAKAEVDALPEWMKAYESSDSESDSEVQSGKRKRTRTSQLSIHASIYSIASHTSVYTSLWESILSSVPLDEVWTRKILVGLHGEQGMLAHFKKERRLRIADWLGSLVDAGGAMAMLAMNGLFVLMTEYNFEYPNFYTRLYSLLTPILLHTKYRARFFRLLAIFLSSSLMPSTIIASFIKRLSLLCLTAPPQGIVMVLPFIYNLFKKHPGCMVLLQRKSSGDPLLAVSSFTPTTTTVNPKDVDPFDPEEKDPLKTKALESSLWEIAALQRHYLSSVSTLAKVFGEPFTKAEYNMEDFLDHSYNTLFETEANRRIKNAPALSIDIEAAGGKDIVAFPPAMKNEGDEENGDLVTQLWAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRQ4</accession>
    <name>A0ABR3BRQ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613836.1">
        <property type="nucleotide sequence ID" value="XM_066758434.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990809"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013">
        <property type="entry name" value="THAUMATIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013:SF2">
        <property type="entry name" value="THAUMATIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1468"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1370"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1408"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1435"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1476"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1497"/>
            <end position="1529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1728" mass="188708" checksum="44ADACCC788299F0" modified="2025-10-08" version="1">MIGDDSSGSEYGKPGATLAEFTIDVNHMDSYDISIVHGYNLPMEITSSDPSCAKGSCGTETDILTQCDPSLVYPKNSDKIYSYGTGGDLISADANNSPVCCVHNGVAVHHINCPNTYIPFYQTMKKMCHNAYVYSDDDMYGDAVFTCPSTNKPSYTITFCPNGDAAGLNPPSSSLAVSQDSTPGDNSGNLSNGPATVSIWTAVTGTLIESGSGAAATNTAQSQINTGAVSFSAVTAVTSAKSKAITSAATIFRDSSNRHTHSGWVAAIELITTSALAMTSSAVPEQLGGSITTYTSSGNTAELRHPQTAMDRNGSSSTPRKKARQTLNPAPIVSASTSSKQRSKKVNERDKDEDVRNYDSSDMTDGSEFESPVEDEEDNKQIFYIDAIMYAHFRDSRSRKDSLGWYGWHYGVMASYLKSLSDTEEPLSSFETELNIAPLVTSFWQAVDTPIPKGKLEPPGKKGDYYEIPPNQMEEMLLTCYPKRTWKIYSRRRAKQRAHQLAPPKIRNKPLRIQKRDSDYYNYERYKKRRKTMHESEERQRETVGIKKKEEKKPQEWVLTSASDSDSTEMSLDDENDALSTSDKRPQGKSNKDPRKTRKYVASSSEEENQASLEVTNVKKKKRRITSSASSSVPSFFDSPRSSKPKERPIQPSVEVKVPIAADQMKSRQPSPATSSAQLSFGQLQPGIFDPDPPVEATLGGELCHAPRTAASTVISPLSAATQSFTTMQQSQSHPLQSVRPSQAPGQTQTRNSRQLSLRFQPQPQPQLQAQSALQPQPETQTPSSLSAASVSGLPTGSPKSQPKSTSLPENQRQQTIADTNSTSNTPLSALPQHNSRQDSQDNACNTISPRPNSIVLVDQQQKQTITGSVEPILRAPVNCLFEDSTTGASRPSTTPSSRQIPIRNQPSNLSGRTSVSSLQEPIDLTSPPPDNAIDLPSSTAALTNAGQNAPSHVENTIAAVRKKYEQPKLIKTINDANIGTQTIDIRAIRNSRKEQEHDAEAPHLLSQAPGRQKPKELTRAQRRRLDEENLTSATRLSTAMLHRQSSQDIGTRPSSQSRQSSADPLSKTDSRAWRTASVSTNAGSMSPTAARKRLDSRSPETFHRGDTSRSNERFSPQISPGQSEGGENNGNGKNATRPRHSLQNGDDFRMDTPSVVPQKTTIAATTIPTQGNSSTRVPPGATHGSPIVVVPAPMATTDTQEDNEESLFTRPPGQEDLLFTPIFDVTDEILDPAFALSPVLVGQPPIQQSSQTSLKLHLGLPMPEVANPVQTAQDVQLEKGRIEMGLLEGQREGQKGEEQQEKDQVNAAEKLTKVREMQKWKEDKEKAVREKIAKMRPGKERAGSEKAAFPQIQFAQKPPMASRISQSYQPRQPAVQVQQPSHLPAPIPTQPQALPASQTLDHPAAQPSASTLISSFVSPTAKQTTSVPDERANNRAIRQRSNASAQSSADQVQRRSITPVVQNAFRPVSQPPLQPKSQSSVQLSGQQPTQSPTQSYAQLTTQPTPHQTFKVSSTLPPQPTATYPSTSSQAVLAQPKRVHHDIIYSLDTLLRLRRIRSDGPTEAFNSLPTPASAAHEQHRSFPTLCPVNSQGGIVTFAPSLILEEPKLFENLMEALKKTTLWGAYLAPSVITYFDQSWGDEDLCPDVMESFAVLTAYLTLDGGFSQLFLTDENHPNGNVLTISCNPPASYDYDACLAWFQWLQRVTKRQGKEDTVLELIFSHQKSSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRQ6</accession>
    <name>A0ABR3BRQ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613834.1">
        <property type="nucleotide sequence ID" value="XM_066758432.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990807"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="256" mass="27924" checksum="7D7710229854644E" modified="2025-10-08" version="1">MATYIPPEEQGQIDLAWMREALIMAEEALSNDEVPVGCVFVKGGRAIARARNRTNEWRNATLHAELEAIDHLLPSHPAPLSTITLYVTVEPCVMCASALRQVGIGRVVYGCGNDRFGGCGSVIPVNNSPRLDSHPAYVAVGGFYREEAIMLLRRFYMSQNPNAPKPKKKATRILKTDIPPPPSRNTTPQSSRPSSTTPSQRRPVPSADASTTGTSTPALSEGENKSQERIMRDDGLPIGSTMVSTPSETPFPQERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRR2</accession>
    <name>A0ABR3BRR2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613555.1">
        <property type="nucleotide sequence ID" value="XM_066758153.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990524"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="631"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="680" mass="74048" checksum="C00E2A0844FEDB75" modified="2025-10-08" version="1">MLNLDTISRNLFGAGSVSGRSGTSNDMFSTVSSKRGSRYAMSRSSSMETSLHSTDGHEEKDASKKKSSKISLSPDPHSLIAGAPYAAGTESIRQSEIDLNQRLDAAKKNGQSTTVSPGSASTLNKLGNRSVTELRRDHEDMAEGRISRIMTTTDSPIPPSSPLKSSSPLRIRNTTPPKQPTSPDVDITPQARLPPQIITSPVTAPLNIHKTPSRTQTIRSEHTMISPSRAISPVLSVSSTSLSPKPSLTSKPSLSHKLSMSRPGGPRGPVSRSPFPNVKTQLPNTAITPTSAAGSRHNGLRIVSGSGRRISLNRETIPLKGEEENDPIATNTPSAPAAAKRQHSVESLSPRKRSPSLGKNPLGEIGSNPLLVIKPHRRTSAKIGAPRRTSGPLMSARTVSASCSSINSVASADTVNTVNTAGTYGSGEGVEMKEYEDVVGAMDAALKKIHDARGSAKRLKSEVSGLRKQISRESGKTKQSLAVMIDRAGSLPRSPQKRHISRMMEQDVHDLSPSLSRQTSQSRKDIETDVMDECTRGIVQITQRMDGHLRQAEVDAEQAIALSRRVIAENDEKHREINMLKGQLERSREYQELLQRQLGDAQIELDVVYEAFNTELDGMFNDAQLPEDEAFQALRNDLQVTKANRNVLQLENQKLKRELEEANLKRNQWARILRAQGYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS19</accession>
    <name>A0ABR3BS19_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613941.1">
        <property type="nucleotide sequence ID" value="XM_066757557.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989911"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0249754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="72" mass="8455" checksum="E4BBB4A4432CDDBF" modified="2025-10-08" version="1">MRPFSILFSTLELDSRLFFLRENWLSRSPQLMTSKTDSDRKDLTFIAPFLHTHLDHCNTASPRNNVKKTCNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS98</accession>
    <name>A0ABR3BS98_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614014.1">
        <property type="nucleotide sequence ID" value="XM_066757630.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989985"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="652" mass="71000" checksum="AF8E1FF60332513C" modified="2025-10-08" version="1">MRSNSNPTPPSRTLSSSSSPRGRGGVSPRPPPSYARSSLDRSPSLNPMVLDERPRVPPPIYLRSSSPQPRSNVGTLKIHVPAWSTCLVKPPRPLDLHPLEVGSSEHEPPSDDTVLSGALEVIMKERKKVQSISVGVQSVCRLHMGKGRGWEEDGIFERGVQVLGEGNEDGIWLEKGRQSFSFSILLPATLATSDYHDFGRLTYIITASVQGIAQTSSFSSIFKAVTSPPFLDPDIPFVGDFERVIARSDKLLAESRSRSGSRTRSGSPDNLAAMRNFSLGGDDGTCAITIGGDSPPMGGLYTTRRHPSSVLSSASSTSIPTLSLGSEEEDRGRPRFSSFSDISSGSGVQGKADKADWMKGDLCASRELLIHAVDPLTGGEIPLDVRKEGFVEGLGSWRFTANAEALSISSVILLSMNIPTPTPATTIFLLRLALSQTYTFTSPRTPNQRPHSPEPAKHHVLYQIGRQHKAGEKYPGPECESLWRGYLAGGHGGLDGQDHGWNVRAVARIPSHDKIRPSTHDGTITPIRVTHQLLLQVYYSIYGESVKGEKIKGPGELRLMSVRVPIHLPSCHCLSDALSLPTYEKCRRSTDNIDSIISSPPNMKTWCMCGKTFAELGEAAMKRMQAAEWEDMEERMRRSAGDGSSKDLQSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSB8</accession>
    <name>A0ABR3BSB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614030.1">
        <property type="nucleotide sequence ID" value="XM_066757646.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990001"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="66"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0249843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="195" mass="22222" checksum="519C978BEC52EB8D" modified="2025-10-08" version="1">MGKATKTRKFAAVKRMIKPSDPRLKENVEKAAKKVEKEKAAEDRKAVAQVSSSLFLSHNTDLGPPYRILVDTNFINFSIQNKIELVQGMMDCLMAKCIPTITDCVLAELEKLGPKYRLALKIAKDPRFERLHCDHNGTYADDCLVQRVTVHKCYIVATCDRDLRRRIRKVPGVPLMYVAKRRYQIERLPEGGASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSC0</accession>
    <name>A0ABR3BSC0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-nucleus import-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614009.1">
        <property type="nucleotide sequence ID" value="XM_066757625.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989980"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008636">
        <property type="entry name" value="Hook_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05622">
        <property type="entry name" value="HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Hook C-terminal" evidence="6">
        <location>
            <begin position="256"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="556"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="696"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0249822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="824" mass="92526" checksum="D540112F1025719C" modified="2025-10-08" version="1">MSRQEKDALVAYVNSFKLSKPVTDFAQLADGKALMETMSAVDSTHFKNVPARGITSQASSSENWVLRMNSLKRLYRLLLSFPLPAPHPSSLSLSSLSDPPFSTIAKTPTMKEGVQGLVQICRFCLAASVWAPGNEKVIMRIQKLKEEHMAELMKSIEAVTSTLPAEHQRQDSGTSSLRPSPDLSYSPPPSGLREERDRLLQENDDLRTKCERMMEQVADLTSKLEEAEEEHEDTLERLSRGETPGVGLRSSQAAGASEVERLKADLLKAEESLANAEEDLEKQTASVSELTKQIEQYKAKAAEAGKLKDQLDEHRHTADRLRKSENVIEKYRKKLEESANLRRELRNLEEENASLVNSNSSLEADLKNAVAVKSLLDNYKSQIDSLEKQTANQATEITELNHQLEATQHQLESLQSTYEQNQEELQLSQEKLREIELTGVTPSNREGLKRSMFGLEAPGDISLGDELGELSDDGSRETKTDLRLKVKFLQRELSDLQSSAPESRRLITLETLLADANKSKDRYHADYLKAHKESLRLSAALEAIREGRGGDNSQTSAALKQRLDEVLEERDALLKERQELEVAKEEAEKALAAAKVDLSFVGKDQRDIIASLREGIEKDASNLGKEVTELKEQIEALREKDRQNLEEIKILLKDKINLQTVSIDQREKALEKEKEFSELKASMSASGVSAEAQQKLLGLHERNIKLSAEVKDLQDKLDVLSTSGDTHTYEHSPFEHAQIAYEKQITSLQEEVTKLKESKATLTKQYDLEQQLMLTAWHDLGQKMVRGHLHVAMSGAKRSQAKPMPNGWLGRQRRIQENAGYARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSC7</accession>
    <name>A0ABR3BSC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methionine-tRNA ligase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613738.1">
        <property type="nucleotide sequence ID" value="XM_066758336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990711"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="6">
        <location>
            <begin position="222"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="396" mass="42477" checksum="2A5998A8FF761C50" modified="2025-10-08" version="1">MSSQVQQFISAAVNADPSLVGQNDKDKAAIEKLVGESEGLTKDLPALNEKLTPLTYLYSNYPSTADVGLYAHLHPSMINAPATQHPTLPAVLRYFLHIQSLPSVSSARSELPNAYPTLEIDLSTLPAPERKAPAPKVKKEKKAAAPTAESVPATAEGAAASVAGAVSAATGAVIEAATNAAETIKEAVVGKPEKDAKKKEKKEKKEKPAKAPKPAAEVTGPMPSMIDMRVGKVLDVKRHPDADSLYVETIDVGEPEPRTVCSGLVKYMSEDEIRGATVVVICNLKPVTMRGVKSFAMLLCASSKDGKEEGGVQFVLPPEGSQPGERIYFEGEKYENAIPEPQLNPKKKVFETIQPNFMTLENREAAWIDPETKSVHRIRTKDGVLKSQSFVGASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSX6</accession>
    <name>A0ABR3BSX6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614241.1">
        <property type="nucleotide sequence ID" value="XM_066757857.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990215"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052732">
        <property type="entry name" value="Cell-binding_unc_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43883:SF1">
        <property type="entry name" value="GLUCONOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43883">
        <property type="entry name" value="SLR0207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="337" mass="37467" checksum="019A88D6BE4BFE56" modified="2025-10-08" version="1">MMDKLLYTEDRTDRYSKSEVQNDAQICDRFHATIRDLSPQSANALSIEPQVLLILVGLPGSGKTTFAEALVRASSMPITSPEGAGKVRPSVIRRPWIRASQDDAPRKRRQECESRVRWGLKKGYNVLVDRVGFDPVQRSHFVAIADDQLSRPLVYCLILSVSQETLQSRLLGREFHPTIHGGEEGMRVLSQMRRLFQPPTIYGGEGLDRIYVLDEINQPNVAEGWNSQRVLEIVDRVGTCGRSEVGERKSYRPAPRIHDDNASLRGASANSRGGRGGMWGERRVRGLWDDRGGWRGRGEYVGSSNGWSREGALPPASLSSHSPHNRSLGNESAPEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTR2</accession>
    <name>A0ABR3BTR2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614512.1">
        <property type="nucleotide sequence ID" value="XM_066757043.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989355"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="115"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="586"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="592"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="624" mass="66813" checksum="7CB1E9630789A63B" modified="2025-10-08" version="1">MPGIMPPFQHPLSTESLAPKAELLAASSGQVSLPPDPSPMTLCEPRLATASGEIKLERISTRGTNIDSSVSNESRKERDIYEEHPVESLDRLPSKVATIKHTIPPRLTTPRLIAISAILTFTMCMSAAGQQALNIALPTIQTDLGMSESNLQWITSAYTLTNGCFLLLSGRLADIHGRKKVYLAGVTWYAIWTLIGGFMKNGAALVVTRALAGSGASMSTPSAVGIIAHTFSGRARSTAFASFSAGAPVGGALGLILGGLFTSYVSNTWRGALYCIAGLAFAVSICAFFVVPNDGSHSSDRRVDWIGATLVTVGLIFLLFSISDGENAPNGWKTSYVLALLIIGFFLVVAFFFWERHIINNTTRPPLMRLQLWTRAKGRLAAVYFIGFVAWMGFTSLFYHATLYYQQVQGTGAVGAMLRFLPTSISGILCNVLVAFLVSKVKTQYLVCTGLLATGIANLLMALSQKDTLYWRLPFNAMWLSVMGADFLMATSLIFVAALALPDEQSVAGALFQTLIQLGGSFGLAVTSVISDVQNQKALRAGKDEIEALLTGLHAAFWLGAAMSFTALIIALIALKGMGTVGNGAKRGGLTDSKHKKEEKETGEEGVKAKDAVQRCDTNDDDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTT3</accession>
    <name>A0ABR3BTT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614263.1">
        <property type="nucleotide sequence ID" value="XM_066757879.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990237"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="439"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="539"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="539"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="608" mass="65065" checksum="EA0404379B28D6E1" modified="2025-10-08" version="1">MSDSVQVTPRKRKAGTIINDAAEAATASTPRTARTSKNSMLVNLAPVPFPTPPATRHRALDLATRPALAPAPVETAKSEVSNLPPHLETLLGIQKAFNLALSLYIATHHPVLPPHPPTATSVKLPNLTNYLAIKETVERTCGRRFGAQELGRLAWVWSWDGKPLSDENSMSEKSKETGKKAMLEEDNPFFVPSSPALGSGEFSGMSYLITSTRTLDPSNGRRVYTHGVGIELELRKGETRQLLSNSDGGLGNRGQGGGTGAIGRWNANGETREDEFRGKLEKWVKLHGGYEPPEATALPTPTTSETSTRSAIPPIPILPLPQLPSNSALPSTNLMAKFTSPSSASMTMTPKKNHLPPAFSSPKTAGLSDPFEIGDPESNGQSKGKIVRNGSVEERRKAMMERIKARSGANKAVLATLGSAAGGFKRPGVNLSALSAVGQQEELKRRSTLSRLEGVAEAVWMMFSAPSPGPSTLPTPPRGRRKAIPMSEVAEIIVKSSKTPISTAEAQTSLQMLTELCPFFLTNKTIGRQEWLEMPMTALSAAPPSPTTSTLTSSPSSSTTLVARQTPSSPSTPSRLKAELAGPASPGRVRRQGGLREVRERIRRELGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTT6</accession>
    <name>A0ABR3BTT6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613710.1">
        <property type="nucleotide sequence ID" value="XM_066758308.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990683"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="142" mass="15360" checksum="BF19295C6D5CD292" modified="2025-10-08" version="1">MVYIKNWTDFETTATDLYARSPSKVRYCVKFQPKTGHLVLKITNDVKCIKYKTFSSIILNRFDSLNLRLLSSMSNTKARPKAILSTTISASETPERGGTPALAGVSGEAPSSAMAPGGQEGTKQGAQGKSNTSGKKKKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTU2</accession>
    <name>A0ABR3BTU2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614554.1">
        <property type="nucleotide sequence ID" value="XM_066757085.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989397"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="72"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="142" mass="15947" checksum="DA11759357B58BA4" modified="2025-10-08" version="1">MPTRFSNTRKHRGHVSAGHGRIGKHRKHPGGRGLAGGQHHHRTNFDKYHPGYFGKVGMRHYHLLKNHYYRPTINLDKLISLPEAKVDAPEGSVPVIDLVHLGKFKLLGKGRINKPFIVKTRFVSKLAEEKIKEAGGVVKLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTW3</accession>
    <name>A0ABR3BTW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614570.1">
        <property type="nucleotide sequence ID" value="XM_066757101.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989413"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28876" checksum="05126992183E0E8E" modified="2025-10-08" version="1">MKENHAVENALATIGAVLWMIQNIPQVIKSYREKSTKGLSASLMFIWAVGTVIHGAYIVAQNFSIPLQVQPQVFAALATVSWCQCMYYGRGYSLKSVLAIFVVLCCIFAGFEVGSVYALWAGQRNGVEWPVLLYGYLSAVLLAVGLLPQFWEIYKYREVIGISILFMAVDILGGIFSFLSLFFRESLDIAGFVSYALVVVLDGIVVLLYFILNPIAKRRRAREAEKQRPDSEAGIEGGSTTPTSTAPTLVAHGFTVEKEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTX6</accession>
    <name>A0ABR3BTX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614308.1">
        <property type="nucleotide sequence ID" value="XM_066757924.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990285"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="252"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="431" mass="45851" checksum="044BFEAD0C3F3038" modified="2025-10-08" version="1">MLSAALRVLARSAAIQREEAAARTTTVAARTAAATATATAAARTAAATAATPSGQHGQWPNTKTLDAPPASHGAALAALDRLIDAAPHQPPPPAPRTHPADKSQPESVKPAESVKPVETTRKTSIVKEQAVGDADAAVKNGQAEPLIAPVDEEETPVILRASRVPASRLGRLFHYGSLAASLSIGAASESIRRSTTGSNGSSGSVFMSDANIRRLVSTLGRMRGAALKLGQFMSIQDNHMLPPEIEQVLHQVQAHANYMPDWQMDKVLREELGADWETSLFAQFDRTPIASASIGQVHRATLKQTGQRVAVKIQFPGVASSIESDLSNLSLLLRTSALLPKGLYLQNTIAVMRRELEDECDYIREAAAGKKFAQLLAGDPFFVVPHVVDEATTGKVLTTEWMDGKPLSRVKNLSQETRDLASPPSSPSPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTX7</accession>
    <name>A0ABR3BTX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Monocarboxylic acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613428.1">
        <property type="nucleotide sequence ID" value="XM_066758026.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990388"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="47661" checksum="A0BEE8773C69D8F0" modified="2025-10-08" version="1">MSSDVELSQLPKQPSQSTIEHPLAYDQEVDESVTHHALPPVDGGRKAWSFLAGATAIEMIVWGIPYSIGILHVYWTNTLFKGYGESTVTLAATLQTGLLYMSCALFGPLFTKWPKWQKTFQYIGLLAASLSLIASAFASKPWHLIVTIGCIYPFSGALYLPCCTLLFEWFVAKRGLANGAMFAGTGVGGVAYPYIMSSLLNRFGYKTAMISMGVGYVIMGVIALIPVNRRVPLSRHDFVGPGRKKPINLTFLRSTPALIGPIIILLVSLGNFIPTLWLPSYADDIQMHRIDGTTLIAILNAASVPGNTLLGYCSDYSLRAVIIISCVGSALGCAFLWGFGTSPGVLIVFAIIYGLLGTSFQALWSNMIGVISKDDPIAPSLVFSIFAFMRGIGNITSGPISGALLKHNTFPNGAGAYGLHNYGALLLYTAITIFSGGVAGIMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUF3</accession>
    <name>A0ABR3BUF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxisomal biogenesis factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614759.1">
        <property type="nucleotide sequence ID" value="XM_066757290.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989610"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30076" checksum="787E575EF3B0D867" modified="2025-10-08" version="1">MSTLATNIILHPRVNQSLAILATTVGRDKVTRLIQYLARLISWYLLSRGRIESASRFEGLKNGLANGRKVMRLFRPAEFLQSAVNLAQRPITSLKGPGQIAHLAQIGRQIGYAGFHSADMIVWLAQIRFLKFDKTTTQRYVRIMYKFWLAGIVCSLVSSSASLVRLRADSRRFALSSQVAKEEEKDGRSGEEAARQMSERRERGKALLDQRQTILSQLVSDSLDVWIPATGLGYTNLNDGTLGTFGVITSYMGLQTLWAKHSAAGVKKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUH0</accession>
    <name>A0ABR3BUH0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103049</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613935.1">
        <property type="nucleotide sequence ID" value="XM_066757551.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989905"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0249748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="240" mass="27036" checksum="323F7A567148FA11" modified="2025-10-08" version="1">MSEPRRSRVRVSEEDRKRRLQACEVCRKARHKCEGGGIDENLPCKRCQSKGITCVWSSKKRMFGRQGLNAQRKSSNQTSAREISDINQALVNNGIRATHSPMCSERIPEPRRTVSDTVIAASPSSQRPSTVQTMPSPLSARQLANQYLHLIAEQTQASQQSDATGSQFSQAPLPWQIMAPQQLQNQRRAIHPQDQQEQQQLVLEFTEFASIDDGNVAANGGFQYDSLMRALYHGEINQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUL9</accession>
    <name>A0ABR3BUL9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_102812</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614816.1">
        <property type="nucleotide sequence ID" value="XM_066757347.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989668"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045319531" evidence="13">
        <location>
            <begin position="25"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0250629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="541" mass="57125" checksum="679CA8790BCBFE16" modified="2025-10-08" version="1">MLFVTMTLAQLCSALLFMMLPVSAHIALWDPAMYGWDDNPNQSDPVTPLMDLPFDQWWFHGYIDLPPTNNSIMELPAGGTYHGQVACNKALTSYGLVPAQQTSIYACDGTGPSGGIGAMHTNDAWESTDPQDVKGCAIGIAYESNVTKIQPEDFTVISVNYSCPWKKHVEFQIPPNLPPCPDGGCHCMWGWVHAADAGSEQNYFLGYRCNITGATGVMPLPRANTANKCDYPIDTSNCTAGAKQPHYWFQKERNNNFQDTYDPPFYNGAYGFMNGAQTDLFDALNTSNLANTNATMSSGNASASEVSGSSVVLSSTIVTVPGASSSLIVSSSIVSSVPSSPNIAITTTQTTESFSSATMLPADAVTPLHTSPSSSDSEISPSASTSSAWDDIADSATTLKTTLTRTVTMYRSSTALTASASSSSDGSPTSDASFMAPISVASSDSSSKATSDSTSTTVLYTSVVSAPASSSSSTSTTATTTPVTTVITPVAADANLSITSSTCKLKRSGVRKHKIKRGRRRGRFLGRAVGRARGQVPRDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUQ7</accession>
    <name>A0ABR3BUQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I308_102869</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IND107</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614873.1">
        <property type="nucleotide sequence ID" value="XM_066757404.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989725"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="79"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL0250686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="484" mass="52416" checksum="102FFE5E4D9C2127" modified="2025-10-08" version="1">MSAAASSSTATVQPSGIITQPPPPSTLREQRIATHSHIKGLGLADDGTAMSSSQGFIGQTLAREALGLHLSLLKGGKYSGRPLLLVGPPGTGKTALALALSQELGSKVPFCAMVGSEVYSGEVKKTEVLGSCFRRAIGLRIKETKEVYEGEVTELTPSEAENPLSGYGKTISHVIVGLKTVKGTKQLRLDPSVYESIQKERVVVGDVIYIEANTGAVKRVGRSDAYASEYDLEAEEYVPLPKGDVHKRKELVQDVTLHDLDMANARPQGGQDIMSVMGQLVKGGRTEVTDKLRREINKVVDRYIEQGVAELVPGVLFIDEVHMLDMECFTYLNRALESPLSPYVVLASNRGISTIRGTEYDGVAGSASEGIRAPHGLPVDLLDRCMIVKTQLYTRDEIRRIVEMRCKVEGIAITSEALDKLADEGERSSLRYALQLLTPSGIVSKNKGKGEVGVADVEELGELFLDAKRSAGVLRSTEDFEKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUW7</accession>
    <name>A0ABR3BUW7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614933.1">
        <property type="nucleotide sequence ID" value="XM_066757464.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989818"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01427">
        <property type="entry name" value="HAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052419">
        <property type="entry name" value="5_3-deoxyribonucleotidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134:SF2">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="301" mass="33700" checksum="B90DC264C65F7ACD" modified="2025-10-08" version="1">MPNTADPETQVITADGMATPAGKSSIGKGRIAVDMDDVLCQTNATIVQMHNELFGLDPPLTLDDFENYLYWMNRGWGNPEETVSMVSKLYQNGLYMRAPPVPGAKEALQKLKDMGYCLIIITARSESQREGTEDWIMEYLPDIFDEIHFTGAFQDLEPTKEEHEGHAARKAIVSHKKRSKAEIIHNTSSLFLIDDSAENAYDIATSCYAHPHATKVLLFGAYPWNAVVRSPESTLPIEKMTYVAKKEKGLLGESEKLRKDKIQKGWLPEGVIRVNGWKDVLKWVEAFDKNGGAQGNQINKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV45</accession>
    <name>A0ABR3BV45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614989.1">
        <property type="nucleotide sequence ID" value="XM_066756212.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988516"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="612"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        <location>
            <begin position="714"/>
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            <begin position="814"/>
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            <begin position="1207"/>
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        <location>
            <begin position="1307"/>
            <end position="1320"/>
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            <begin position="1328"/>
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            <begin position="1383"/>
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        <location>
            <begin position="1437"/>
            <end position="1450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1461" mass="165747" checksum="32357DE344437D8C" modified="2025-10-08" version="1">MGIPRGIGGIVQWMKENERGMGCMSYIFSPYSPPFPLSEDVLSSLSPTTSASLRQNPLALNRAVYLSNLATFVWLILRPDEAGDIMGPLDVDEGNDKRVTRSRQGIDTEKEAIKGRVRRRNALMVAAWKKYWTAIIPRGQHRKEIALRLWLDLVTQIEISYRLQTITSSTESDFLPQIDDVLHDDMFSISSISRFGLPFDQDTSGDEGDEEMEDHKLYLHDLWGDLSVEREEELPKLELEEARAAYPWDDFQRGMLRFVKDEILGESGEESLLTPGRRGVLAGTQTRTTQTRGRSELDNERQESEESPKLSQEVAQAPNSPPRPFTDWPARKNSSPGDGPIDFDLLEEIARELAAEEPNKVDAVFPLTHGGSGNGTGDGSNSRNSPETSSTWAINESTSTPVPSRPSSSRPLSHENQSLKQTTTEKGKGKERGPLNLLGKKAKRDGFEWNKRQERAERIAWESQSQSQASTPQQVEETQEEIESTAYDASDLLPDARQFRFTNPRSNLRPDEANEDEGYLEEDVLLDLRQLDRVQQAVGAEEEGYEVDIMLNSRQLKARPSGELVAKQETKNGEEGYEEDGKVLTDPGQFTRTTRSQGRAFQQKETERATAGASTRAQKAETQIVEEEEQDDEHDYNELLGSLKESPTSGQPEQQAQIPAGDEDFVFHPNPDFPFDDLRRQAEMDDYDVEDVARAERQAELEAENAYEGTNDDYVVKDTSAEGRGMSEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEHSPKGKRAYSSAFAAISSSEDEADRQRILSRRQKSFETMSSQKRSTQPQFLGTSLFSPTSPDRFSPNRQASAGPGPSTTRNRHAAAQPSSSARSVSFENDESPFQKEDGNVSTTVVVEGDPFLVDEDGSPLTPSEEYTLPDDRNRQFSFFKSNLYGRTSDKGSRYVRLSGPRRWTKEEELLLWRTVQRVPATQVYPLRVVWYLHGDGGRFSEKLRWFSVQHMKDKMRTTVMRRLRSGELVEGNARAWAPLGSKEKENWDEEEWDRMDDRALLAIQLERQEFEKRKEAARLREEAREKRKEEKRRIEEEKKKEREEKKRKLQDEKARLKEDKRKWAEEQKRKREEEKRRKEEEKQKKKEEREKKAKTKKGTGRQYRESEDERSEESEESENEEQQDEPQEEVDELESRADGSVGSESTASPPPPKRRTNRASASNINPKRNTKKGSKVQKGAGAEPFGKSAAVTRSSSQTNAKGLSSQSKRLMMEAWKSHVAANSEEDDDQENDEFENEDEQTASHLPARSAPFKATAARKTTSQPVKQNQGAVTARAARKTTSNADGSTSRPINSAYVSSGLSASDTTKQSATKRTQFDEGDLTTEKGGKMDQGSESEVDELQEELELESNSELEVLPAELNEEMADEEGIHPPLGQGTHAMMARSVRSDPSAQATHVSGAQYTGDAEQAEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV79</accession>
    <name>A0ABR3BV79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4460 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="99"/>
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        </location>
    </feature>
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            <begin position="71"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="108"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21809" checksum="1B50FF4753295170" modified="2025-10-08" version="1">MHLVFENVLTTLINLVGGTFSNLEKEHFVVAKEKWEEIGRCDYPVPVSPIFTDALSLTRNSSPGEGPPVQMTNAVEELQRANAEIARLREQLLAQSASSNSPWSASSEDTPVSSQAQSQFPESVRFRVPQAGFARGKTWKESTFVQRDLFTRLMQDRHPDLFSREKITIINALHVPQGFHQDQVHEGACGAKSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVC1</accession>
    <name>A0ABR3BVC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101733</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615064.1">
        <property type="nucleotide sequence ID" value="XM_066756287.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988591"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="9">
        <location>
            <begin position="348"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="275"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="432" mass="45745" checksum="77948F7F24284797" modified="2025-10-08" version="1">MSKYPQRHHSPYHPSASLAQTSQQQQPVQYIYDPSQSYASTNPSPQLNGNLARPTNSGSATTAPSSSPRFQPYSRPQPQRSTTSNSTQSVQQNNNMSLPHAALPPSNSIHPPPQISPSHQPSPLNQPAFSFLPPQELLKSYSDPAHTPSNLPNSLYNTGYDGIIYSNTGVQQPYLPVLPDAGNHEAWDRALNDQRIGPDEYSQALAIYTHIYDSVPYFVQNTQPAPHIPENHNHTTTYESIVHLANEGHQILTGQMNSHQQALTPSTGVGVASLPTGIAGHVHMGPSPGPGASSTNHVNPTSNNANHGNGVSIGNGKQGSSGSASSTGALSGNTMAGRKRGNSGDKKNGPPPTCLGCGATETPEWRRGPMGPRTLCNACGLVHMKLQRKKKKAEEKARLEAEKEKEAASALGVVGGTFGGGLASALPSAFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVD0</accession>
    <name>A0ABR3BVD0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_101651</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614982.1">
        <property type="nucleotide sequence ID" value="XM_066756205.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988509"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0252262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="252" mass="27276" checksum="1430E8E3424181B0" modified="2025-10-08" version="1">MAPQQRKQPDMAQEKQRALHQYRNDHGHFSLVRNFRLADLITIMNGVCGTLSILSCARYILLSANLAGPPSAGALRTLYFAHLLPVLGFGFDALDGKVARWMGGGSMLGQEMDSLADLVSFGVAPAVLAFTLGLRTPLDLFALLLFVSCGLARLARFNATVALIPSDPSGKSKYFEGLPIPSSLALTTMMAWWVKQGTYAHPTGFTKHSDVPFGVVTLWGENGGWGQVHVVSALFAVWGAMMVSKTLRIPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVH3</accession>
    <name>A0ABR3BVH3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_101771</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615100.1">
        <property type="nucleotide sequence ID" value="XM_066756323.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988629"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="12">
        <location>
            <begin position="304"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="699"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="699"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="420"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="755"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1005"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1214"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="912"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="763"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="800"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="838"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1067"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1097"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1214"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1244"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0252380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1267" mass="137928" checksum="9C9F17DC204FE377" modified="2025-10-08" version="1">MDSQSTHLQLRNAVHDALETRQGEVTNLTAQHEGSLKQLFLMFKPRNNMLDREYDHQAIQGGDESLEGFDEWREQYRLGGGSSVNTISIPNLPAISPPATTVDYPDEPSVDLPAVASSSTSAARPNAIREPSPSPIDSPLTVAPLDTSVPSLMDGVEEEPTVNMSQIQPRPFVPREYSPPPELDVPEWVPLDNYRPAAAPTTPPQLLMPLTSAYATELPPLPLFSSTSSSASSRRRKRTNSPQPDMFKLQATFSINPLSSALARSSKCVLTCDWKVAMDEMRHVRAMERIEAKKAENRWSLRQPKKARGPGVPKSHWDYMLEEMEWMRTDFAEERRWKVVEAREFAYQVVEWHLASPEEKKTLMVGGRGWGECRNVPIPGNTGKRKEVTVEVEAEDEDVEMLVGQEGELDGEGEANKVLESIGEMRDNEKERENLPEEPRETDNINQNTGEEVDAEGETDADGEPDNGEMDAEGEPDADGEPVGDDVVGLSEIDAAQDDTRETSERTSGRHDTILPNGLVIHKRFANAYEIAIARGPVLDTPLANAIVDLDTLTKSSSTVTPATVPAEHPVSPDEPPAFDQLFPDLSLYSGPAPPENDKRYRRDEGGTFSHRLAHTSRIMDIRPILVSTLQPAKNLIDGEWDLHDGPYYEEVKGAADIPPNVVAAFNTPFGGKASRPLEHMRVSEVPKPAAHHLRAQLPWSPEEDKCLLKLVAMYPFNWDLIADSFNTEMILIPVEKRNPYECWERWYYTFGEGKNKSRQDVPASAPASAPASATQPGTATGTPMPQSAVTTPGIPPSAGPSTASGRPQQGNGISVSTLPTPTGEALPDGAPPPPGMSKRDRMAAKPKYEGTKRSIRHQAIYDAVKRMNRRREATRAKSHKDNAQRKVINVHESHSMSFPHVAASTPWELVEAKYQRDVQIAQQRQQRAMQEQQRQLAIRQQQAMMSAQQQAQMRPPNMPNVTNMPNAQPIRMGPNGQPMPNMAPSQQQLLNAVAAATAANRQNANGTVQGNPNVRPMPAVQGQSPQVQQQMLLQAQQMAAQQARVLQAQAQAQSQQGRAASMGGNLHSQPPQLGVSSPFAQSRTPDLPAEGAGPSGITTTPSPAMQATATGAQSSPQIAAMGRAPSNNVPPHLRIPNAGASSPQISSPMAMPQGIPNGAGMPVQGTQTQGMQIPPAMMNNATVQQLLATLAASGQQMTPEQLRGLMLRSAHMQAQAQGQVGNPGTPQMGMQNIQGVQHFARSPSLQTAQSQPRSSPKSGPPNGQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVN1</accession>
    <name>A0ABR3BVN1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614340.1">
        <property type="nucleotide sequence ID" value="XM_066757956.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990317"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33831" checksum="1E5802404B6AE140" modified="2025-10-08" version="1">MPSASDQYSLTSPYGYTPTEWVAIVFIVLFSVSGALHLVQATVFKYWIVFPTIAVGAALEIIGWVGRYWSNQNILYNPPFLMQIITLIIAPVFFSAWDYTVLGIAIQNLGRQYSMLTPKLYVAVFVTCDIISLILQAVGGGWAASSTFPVPKAPTNIMVAGIIFQLVSMVIFSLLACDFMYRAWRKKPYQRKLRQLVDEPIRETGIGANEGEKYNAEVERDAIVRGWWWVMAGTAICSLMIIVRGVYRSVELVQGWNGYVISREVFQDCLDGIPMFIAIASINVFHPGFFLPKRRGWRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVT0</accession>
    <name>A0ABR3BVT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615212.1">
        <property type="nucleotide sequence ID" value="XM_066756435.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988742"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="393" mass="45603" checksum="6BA21EFED5FCCEB4" modified="2025-10-08" version="1">MEVRGLVDPLVNWVKEGSDGNWSPSHPTDAQRESILFLCGAFLLILVFWQGKIAYWYTTKRMRNKRTGVIKRVRVWKSIPIPILWPFKILTVLYHELSHAVVGMFTIWWREVKYGRPAQRGRIEFIMVDKYEGGLTQFGGDQLRPNSTCWLCRKLPHWLLVLVLGVRCQMVKVRICAWVFRWIFCNKEKASKEMDNYFAATRTRNEKANYYHDDNEDDGGPTEHDLHVSQDIIISCSVLVGILLWVAWNWDDSIYLRFIMLGMGLLSALYAVWDIALDGIKYAEVTESDAALMAEVYNHIIQEHNKRHPHHPKRERGARFYAFIWLFAKVIVIIAVLIGAYFCFRETIAQQAIKSREFLPAQFHYGPADLRDDTKNASDAVSDTVSGWIDNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW53</accession>
    <name>A0ABR3BW53_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615338.1">
        <property type="nucleotide sequence ID" value="XM_066756561.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988868"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="190"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="692"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="734" mass="79844" checksum="9508E0AB1FA38422" modified="2025-10-08" version="1">MDAKPLASDFSIMTLVNLSDSLGPERESASAGAKDNTGSSILTTSRPSDMADYSMTPFQTSRSEVQAPIQGAPLVRASTSGSYHAQNALRRMTTHETGEFVEDHDGQATDDGLHTHHEEHEYGHEEGDFNPQRHSEQSHKTVRSGEREEDNREQGKDEEAKIESEKSGQKKKFELQDQTNLLPTKQVIFVFVGLTCALFCSLLDQTIVTTALPTLGQVFGRADISPWVGTAYLLTSTATQPIYGRLSDIFGRKFTLLGCLFIFLMGSLACALAQSMIQLIIFRAIQGLGGGGILTLAMIIISDVVSLKERGKYQGITGCVVALANSCGPIVGGAFTERASWRWCFYINLPLTSISMIIIVFLLPLRRVRGSMIAKIKKLDFYGSILTLAWAAPFLIALSWAGSQYPWDSAAVLVPLLVGLALLGVFIFVEAKMVSLPLVPMHIFKNISVCACFFTTFMNGLSFYATLYYLPQYFQIVRGASAIRSGVLTLPLMLVQTATSFTSGYVQSKTGDYWWNLVAGFTIWTIGLGLLSSITPTTSIAKLSGYQVIVGVGAGQTFQTSLIAIQASVERKDMATATGLRNFLRQMGGTIALAACNSIVNNCVRRNLSGILSGTAYQAILEDPTRAMSLGLSASELSAVTDAYSRGINEVFWFCAPCVGICVPITIFLVKKVTLNRSDDAAKKAEAKAWVESKKAKRAKKRKGSEETVVDSRASMTTTGEEEKTRDGRKGKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWB3</accession>
    <name>A0ABR3BWB3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_102566</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614580.1">
        <property type="nucleotide sequence ID" value="XM_066757111.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989423"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="57"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="553"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0250393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="578" mass="63201" checksum="63EAC59E4E3AFAE4" modified="2025-10-08" version="1">MGRMVRHDLSRERNFRAILHTEKAKKAPRMPGGAGVLSAPLSPERVEAPVTIKAYLLCVFASFGGIFFGFDSAYMNGVLGMNYFINMMTGLPIPGPDADQATKDAFTLPAWEKSLITSILSAGTFFGAIIAGDLADYFGRRITIVSGCVVFIVGCCLQTASSGLGLLVAGRLVSGFGVGFISAIIILYMSEIAPRKVRGAIVSGYQFCITIGMLIASCVCYGTQNRTDSGSYRIPIALQFAWALILGGGLLLLPESPRWYVKTGKVDEARKALSRVRGQPMDSEYIKDEIAEIIANHEYETELTPNVTYLSSWAACFSGGIRNPGSNLRRTLLGITMQMMQQWTGVNFIFYFGTTFFTDLGTISNPFLISLITTLVNVCSTPVSFWTIERFGRRPLLIYGALGMLICEFIVGIIGVAKPGDTTVVKAQISFICIYIFFFASTWGPGAWVSIGEIFPLPIRSRGVGLSTASNWLWNCVIAVITPYLVGTDKANLGSKVFFLWGSTCILCFIYAYLFVWETKGLTLEQVDRMMEECTSPRHSPGWKPHTTFAAEAAHDKPATEQQEKIGAATPTEVLEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWM6</accession>
    <name>A0ABR3BWM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII28-like protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615402.1">
        <property type="nucleotide sequence ID" value="XM_066756625.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988932"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="113"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="226" mass="24958" checksum="98E2DA2BE229F09B" modified="2025-10-08" version="1">MSLALPSRPSFAPKASQALEREALDEADDVDDSDLLDIPHSRKRLVDVDVDPDLEGEKDDDEDEGNDVGVSIGMGTLGVGLAGAVGKEKGKKRDTDDEIEKKGKKRRAETFLLRGQMDEEQARRFDTFSTVAINKNVIKRLNRDLFDQHCPPQLSQVVAGMAKVFVADVIEMAKDLQPHSAHPKGPLQPYHLKLARMCLEEQGMVCSLTQGPASGLRKGKALFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWT9</accession>
    <name>A0ABR3BWT9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615573.1">
        <property type="nucleotide sequence ID" value="XM_066756796.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989103"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="796"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="847"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="877"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="973" mass="104306" checksum="58CA2F3BF2B5F0E2" modified="2025-10-08" version="1">MFAAASNLFSKTSYLSAYTLNSPTPSPSASATNLPSTSAPTPSSSISDYQKSLNVGLWKVTPATHKTTGKEVSVWIFEKRVLEGIKSGVGFGGMGGKEWVVEQLKKEASSLSRLRHPDILHMVEPLEESRSELIFITERITSSLSSLAAAARSSTNYRPGRRPAADKTGMSGRGEGELDLDEVEIQKGSLQLARGLGFLHNQAKMVHLNLGLEAVVINAKGDWKLTGLSHTTSLTQPDGSATKYVYPEVDARLPPQVQWKLDYLAPEYALDSTLSTSNDLYSLGCILYAVHMGGKPPFSNRGSMQNLRDNAEGKLLRRAWASGPRWERCSSELKDLLPRLLTRHLSTRISLLSLPSHPFFSSLAISTLNFLDPTTFASKPREEKATFLRGLIRVVPTFSERLRKGKVLPSLLEEMKDPYLLPFILPNIFEISKGLSKDEFSRVLNKLRPLFTLKDPPQNMLTLLEHLSLFEEKTTPQVFREYVMPLVYNSLESEHLPVQERVLKTIPHLCEILDYGTVQNVLLVKVAIVFTRTRILSVKVQTLDCFKAMVGTLDKATLTSKLVPLLAKIKTKEPAVMMATLAVHEAMGAKVDREATATLVLPQLWSMSMGPLLNAEQFGKFMAVIQTLGARVEAEHTKHLRDVHLIEAQTASLAAANAAALNAGSFGGVGQSNGDGGGDVDFEALVRGNGSGMGSSGSVVPTVGVTGVTDPWDDEGWLNDTPSTAIANNNDGGLASAFPSLSLGINNTGNSFPITTPASVSPRPLSANTTGISLKPSTSTTTTTTSTKLKARPVPASSFNSAAFGSSTSSAGNVSTPMTSSGLPPLQPTTSSFAPLQPQVHPQPGRSASYTSNVSSSGSGPNYNISLNPQSPAQTQSQHLSSPLSFMSSQMSQPPSFSQPVLAPALAPRQQHQQPQLQAPAAPAAPLAPQSVISPPPGWSTGVMQPTAAPKPVWGKSPGETGALDWGDLDPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWW6</accession>
    <name>A0ABR3BWW6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Metal resistance protein ycf1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_102273</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615601.1">
        <property type="nucleotide sequence ID" value="XM_066756824.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989131"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="568"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1012"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1116"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1142"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1244"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="347"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="675"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1015"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1337"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="929"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0252881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1583" mass="174555" checksum="E2FCDBE71E0A67B0" modified="2025-10-08" version="1">MAAQIAFEAFASKHSRPYDCIFPPKIVSSHRDLDFTQCFEHAVLLPAPLAFFTLLALSQIFKITRQLKKGGLNDGLEWITRSRRSERICSTKLGFLSVSALFSLVSLCLTFENISVNLLSAVHYLLLFSTLLSLIHLTTLNHHTSRTSSTIVLLFYPTYLLVSAIRLRTMIDTGALNSGLTHSISGRLLLARQAFWFASILAALPAFVLELYSPEKKWQKWSAPWKRDGKIALEDDEEEEADGIESLDGQGAVPGKNTYGDVESPVSTANIYEVLTFSWLTPLLSLGTRKYLGEEDMWALPSEDSAEALSNRLAGTWKSQAEQVKAGKKKSPSLKIALFKAYGGPYIVAGILKALYDMLNFLQPQLLRLLLNFVSSYTSERPMPPVTGYAIAILMFISANVGTAVLHQYFQRCFSTTMRIRGGLVTLIYRKALVLSNGEKSGRSTGDIVNLQSVDAVRIADVCQYGHIAWSGPFQIIIAFVSLYRLVGWQAFMGVAVMVVSLPANTLISRFNKRYQRRLMKIKDTRTRTMNEILNNIKSIKLYGWEKAFANKIYDIRNNQELKMLRKIGIVMAGSNFIWQGTPFLVAFSTFATFAFTSDKPLTSEIIFPAISLFQLLSFPMAMFANILNSIIEASVSVSRLESFLAADELNPNARTIIRPSEDPHGEPRRGDTVVSIKNGEFRWLEDSIEPILQDINLDVKKGELIALIGRVGDGKSSLLGAILGEMTRSEGSVTLRGDVAYFSQNSWILSATVKDNIVFGHRFDKQFYEQVLDACALRQDLAVLSSGDMTEVGEKGVSLSGGQKARICLARAVYARADIYLLDDPLAAVDSHVGRHIFDKVIGPNGLLSSKARILCTNAVTFLPQADQIISLRRGIVLERGTYEEAMKDSSSELYKLITGLGKQSAVGDEQGSGASTPTIVEEEAVVEEPEGVEESEEAEIVTGADSPKQRKAYRQLSRDIMRRSSVVSLRTAKRDALRELRESAKPKERSEKGNVKREVYREFIKASSKWGVAVFIGAMGLGQGLNILSNFVLRAWASANSGDSGEVPSVTKYLLIYGLVGISGSIASVVSVTTLKIVCALKSSRSLHDRSFGALMRSPLSFFELTPTGRILNLFSRDIFVIDEVLIMALGGFFRTTVSVLGTVVVIAMGAPLVLIVFIPLGYLYRLVMRFYLATSRELKRLDAVSRSPVFSFFGETLAGLPVIRGYGQSARFIANNEARVDRNQACFMPAMTINRWLAVRLEFLGSCLMFSTALVSVAALIISNSVDAGLVGLLMSYTISVTGTLNWLVRSASEVEQNIVSVERVLGYANLDSEALDFIPETKPASTWPQEGSIEFDHFSMKYRPELDFVLRDICIKINGGERVGVCGRTGAGKSSLTLALFRIIEAAGGKIIIDGVDISTIGLHDLRTIISIIPQDPQLFEGTLRNNIDPTESASDADIWRALEQAHLKDHVMNNMGGSLDAEISEGGSNLSAGQRQLLCFARAMLRKTKILVLDEATSSIDLETDEAVQQILRGPDFKDVTTITIAHRINTIMDSHRVLVMSEGRVAEYDTPQVLMQRPESLFFSLVQEAGLEKAITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX44</accession>
    <name>A0ABR3BX44_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614613.1">
        <property type="nucleotide sequence ID" value="XM_066757144.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989456"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="55737" checksum="D146DD80341AC909" modified="2025-10-08" version="1">MPKRKSNPSDHVPNPPLPLSSLDAALDLLVCDTFTRLNSVAAKFEACAGVKLNDGVVKARWEEAVSRYWVIKSMDELTCGAKKIDVKDGTAETDYDVLEQNGVGGNQGKTDNNGRPLPASYPGAVAIHCLSPEEEHEWRKWTPKVGDIVLVDTLEDGLWPAKIIDKKTFFQGRTVPRGSHFFPVRIYNEDMPPSITVKSRLIPLHLRPSPPLMASTALLSAYHHAANPTTFDMLATAREMLAAHNRLHPGVTDEESRAKFKAEKEAWNRQVNWVMGERSTFTPVNEGQGCPDPCEEEIGSLFDCPKKRRTVPRNENNVNPSSDPCSTIFGPTPPAFPHTPPRTASPSVASLIRPSLSNTTRPSSPRRTPTRNDKRRVHSFISDLSPASRRTYTPPMILPSGDETAPPSFGSATLPSEMKDGKFDFVSPLGPVKKGKLSSNPESLASSTSSNTSKPQLGRSGSLEIVREEEEEDGWTVVQRRGRRAGSEPVKQTMEGEEKTSADDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX51</accession>
    <name>A0ABR3BX51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the methyltransferase superfamily. METTL16/RlmF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615414.1">
        <property type="nucleotide sequence ID" value="XM_066756637.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988944"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017182">
        <property type="entry name" value="METTL16/PsiM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037350">
        <property type="entry name" value="Mtase_ZK1128_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="453"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="54918" checksum="177A0305891F7C9B" modified="2025-10-08" version="1">MHQNNPYLKQKPDFARLASRYPKFAPFVNISEDGYPSIDFQNPAALRELTKCLLKEDWNLDVDLREDRLCPTIPNRLDYIYHMLDLEPHLPSSSLRPLRILDIGTGATAIYPILLARLRPDSRIVATEIDENSYRHAKATLEKNNIPSSSISILKSPTPDPILFPLLQSKGKCEEWDFTICNPPFFASTQEMLQGMELKDRQAHAAPTASDNELITRGGELAFITSMIRESIDIGQRCTWYTTLVGKYSSLQPLIETLRDLKIDNYFITNIKQSRTSRWILGWSHTTTRLPDSITRPYVIMENTTFTQLLPSSNTVRFHAPPTVSFATLKAKVLDVLRTVALDPSQDSPDPSQYEGETQDSILITPRINTWSRAARRMAARQESKVEPEGQREASKPPALFRCRIKYISSHATQVDGSPSLEIDWVEGRRKDREAWESFCNFLLSKLGLSRKRQAETEPEGHLPKSSQSHFQGNRTRGRMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXA0</accession>
    <name>A0ABR3BXA0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615215.1">
        <property type="nucleotide sequence ID" value="XM_066756438.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988745"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="241"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="402" mass="43956" checksum="3A8B273162D440E0" modified="2025-10-08" version="1">MTTVNIRRDVDDKFYRYKMPLLQIKIEGRGNGIKTVVPNMEDIARALNRPPTYPTKFFGFELGAQTSMANDRYIVNGAHTADRLRELLDVFIEKFVLCPSCKNPETEIVITGRSGHEDMHRDCKACGRQNPIDMRHKLSAFIIKNPPKKKEKGGKKGKKSGGMTAEANVGGPMVFEKTEDGSGEDETSPDGAVAAVPTAGTEIDAVLGRADPILGDPDAAEAASKKLAKLDINGGGDEEEDEDADSPYAALGSWLEDNKEANDTAIIAEIKDLGIAGKHKVLIEIGQHLFSDDICDEISSRTALLQALVTSEKHQKSLLGGIERLIGLSPSLESLLAAGTTSKVLMVLYQADIIDEDVVQQWGTHVSKKYVDKDKSKKVRKNAEAFLKWLEEAEDESESDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXS2</accession>
    <name>A0ABR3BXS2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615056.1">
        <property type="nucleotide sequence ID" value="XM_066756279.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988583"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="41"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="743"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="747"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="849" mass="94089" checksum="8EB05E0105E296D6" modified="2025-10-08" version="1">MAALNRLSQRIMENFQETTRDLSLIAGSGSSTTYFDTSDERLKEISKLLESRSERERLEGMKRIIAGMSKGRDMEPFFAQVVKNVVSQSIEIRKLVYIYLLRFASTNSDLVLLSINTFQKDLSDPSPLIRSMSLRVLTSIRVPVIQGIVMLGLKKLVNDRNPWVRKTVAGGLAKVYEMDNSSLPSLISLLQTLLSSPSPLTLGASLTAFQEMCPERLDLLHPYFRHICRLIVDADEWGQAVALEVLVRYARAMLEKPIGVGAIRPQPKTEQQKHGDQSEDEFEGIDQDLAMLLYCIKPLFHSRNPAVILATAKAYWCLAPVDHAIVGQRLLVKPLLRLAGSSSSEENKGKEIVALTWEIVAEMVDERPWLFTPYQSSFILHSQDSSLVQKAKLRALGSMVTPENATVSMREFKHYIRLPDVTVAEEAVRAIGSCIKTHSDLASSGLSTLMKLLKSDRETLVAQAVLVLKSIILSYSQALGSSTSSPQHLVARLAKGLDTIVSPKARASVYWLVGQFSAIDPSEESEKKGLGWEGVALWVPDVFRKAIKGFTNESVSAKLQILTLATKILVITQSNPKLELLAQYLFMLARYDADYDVRDRARFLNALLRGVREEKPVNGDSTNSPLVEEKHEQDTGGVVLRREQVKFAVLGRSQPKDIEVVKGGKSGEFEIASTSRIAGKKLKGYEALPDWTDDPTDSSLRDSDLDKPQATTPAPTGISSQTPIRPHAPLHISSASSIPKRAFQNTSSVASVSPASSSPAGSARHTVINKSKFQDLDAFLNSETESETERETETESESEEDNKDARLRDMSYGVCNAAVEYEYDEETDESEDETDSETSEGEEQRLYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYQ4</accession>
    <name>A0ABR3BYQ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_100899</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615748.1">
        <property type="nucleotide sequence ID" value="XM_066755462.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987757"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="12">
        <location>
            <begin position="9"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="11">
        <location>
            <begin position="394"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0253527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="600" mass="63716" checksum="AC5E8259760BDC2C" modified="2025-10-08" version="1">MTDRHIFPDHKTLVFRSIRGLVASHPYLSLIPSQKVVYRADHDPSKVSLICGGGSGHEPGTVGFVGAGLLTASVAGDVFASPSARQVMEAIKRVHSDKGTILIITNYTGDNLHFGLAKLMAQSAGLKNVELVVVGDDVSVPKSRGKYVGRRCLAGVTLVCKILGAASEVDVEFRDLVTLGRSLSANTASIAMALDHCHVPGRSGEADWHLPEGKVEIGLGLHNETGVFSIPQPPPDVLINKLLDLLLKQDDPERSFVKFKDGDELVLLVNNMGGMSVLEMGSVVDEVLTQLESRGIVPTRILNGPFMGSMNMPGISLSLLNLTNVAEECSFVDTSKLIGFLDAPHNSVAWPATSQIYPLPEKLANRKREDKFVDVEEEKKEEVTGGPQLFGDKELIRKAMKQAAEDVLASEPKLTKWDTIVGDGDCGETCALGAQATLKALKEGLGSDGELVHFFRVLTEVIDGSMGGTLGAIFSIFLAGLTTALIDAASSSNGASELTPAFFGQVTSSALETLKARTAARVGHRTVMDALIPFGETLAESGDLKKAVEACRKGGESTVDLQAKLGRATYVGQLEGDMPPDPGAMAFVTVVEGILKAYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYS0</accession>
    <name>A0ABR3BYS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615763.1">
        <property type="nucleotide sequence ID" value="XM_066755477.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987773"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="279" mass="30050" checksum="A3161A0EC5520CFE" modified="2025-10-08" version="1">MSNDFSTQLPSVERSGSLQGVLPDLPTSGGRRWFVTGSSRGLGRDIVVAALKACDKVFATARNPAQLDDLVKEYPNLITGQLDVNDPDACAKSLAAADKLGGIDVICNNAGYANLTSVEDMDIEDFKQQFDTNFFGTLYVSKAAIPYLRKNGGGHILQICTLGSRCTWFNGPFGIHVATLQPGGMRTDWSGSSMDIPKISDGYEPTIGHMATMLRAYNGKEPTDPAKLGQICVRLSRDPDPPMELLIGANAVHHAAEAAQTRKENDEPWKVVSLSAGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYX1</accession>
    <name>A0ABR3BYX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_100963</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615810.1">
        <property type="nucleotide sequence ID" value="XM_066755524.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987821"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="91"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="288"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="517"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="704"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="763"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="715"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="763"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="843"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0253589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="861" mass="96228" checksum="AF2CE34CAE870BEF" modified="2025-10-08" version="1">MTPGEKNQGSSKPQTKQRGTKGKNAQPRLKSNQLKRLKINEELKDLQNRVDNFVPPSEITLFSELPMSSKTQKGLKSSHFLNPTPIQSLAIPPALQARDILGSAKTGSGKTLAFLIPLLERLYLEKWGPMDGLGAVVISPTRELAVQTFMQLRDIGKYHNFSAGLVIGGKPLKEEQERLGRMNILIATPGRLLQHLDSTVGFDSSAVKVLVLDEADRLLDLGFLPALKAIVSHFSPVQTAPGSRPSRQTLLFSATQSKDLAALAKLSLHEPLYISCNKPGEEGVMPANLEQYYAVVPLERKLDALWGFVKSHLKMKGIVFVTSGKQVRFIFETFRRLHPGLPLMHLHGKQKQPTRLDIFQRFSSSKSALLICTDVAARGLDFPAVDWVIQLDCPDDVDTYIHRVGRTARYQSAGTALTILCPSEEEGMKTRWGEKAIEVKRIKIKESKMGNLKQSMQNFAFKEPEIKYLGQRAFISYMKSIHIQKDKSIFKIDELPAEAFAESMGLLGAPQIKLGNQKATKVRGPSKEELAREAEKEEEDDEEEDEEEEEGRAVVGSDEESEEDESEDESEDKRSEDEEEEIDDEEESGEGSGSDEESEGEEGVSKPKAPAIRTKFDRMFERKNQSILTPHYTALITHDADNAAGAGEADDDDDVFTLARRDHNLSDDEEADIDATIGAEALAAELKKPLITSEDLSKRKLKAAASKKGLLKSRPGPEKVLFDEETGEAREFYKSGVDVEKEMSAADKRREYLEKEREIMKIQDKIDKEVAREKKKELKRKRKERERELRQMEMGDEPVAYLGGDDDYDSADEGRSLSSSPAPSPEPERHTKKQRRGKVQESEGGDLEDEEALALRLLQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZA6</accession>
    <name>A0ABR3BZA6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615942.1">
        <property type="nucleotide sequence ID" value="XM_066755656.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987955"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987:SF1">
        <property type="entry name" value="OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="204" mass="22466" checksum="FF4F05BC7C5EA82B" modified="2025-10-08" version="1">MSDDIPPLAALQNIDSLTIVLSTLFEPSPPLHTLLVPSVLERLSSSSLPQSYNQLIDICANVAEGWNWEQKGEFLSGHPMIGEVKGLSKLSGKEQSGGGATPKEVLERLAHLNQLYCKVYPGLRYITFVNGRTRAQIIPEFESILGLPHTSLGIDGPKVPPLNSAEADQMVKTPEMVEWRKECDRGLQNVWLIGRARLNGLDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZD7</accession>
    <name>A0ABR3BZD7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615972.1">
        <property type="nucleotide sequence ID" value="XM_066755686.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987985"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF3">
        <property type="entry name" value="PROTEIN BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="769"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="657"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0253751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1026" mass="113951" checksum="31DE923952ADD017" modified="2025-10-08" version="1">MEWIARLRPLGIATLTAFLCFVSAAVKPWARISGEWGFLVYTSSLIFFFPRGRIGPQIEATVLGISGGTIGIGWSNGTLAVAAWCGRRYGADSNQARAILGVGLALLCIASGLIRSYSRRFNTFSKIMLFFPIFMLTSQQSILHMSASLFLEQFYVIIFSGTLPLLVTVVFAPHHSLSHRFGSEVSESIKNICTLLPLSFHHILGDGSLPETGEDDSESPISAKRLEAQLQNIRPTTQDQLAKKLKAVTSNLQSSSSSYLRTTPRVEGQFTALPAVVKALQRMARNPLLGPTSHIPGERIQAALHKSFPPSAPPSPRRRHKSSNQPIHKRDNLVSAEVDLNMENLTRRKVPRHLTSYNPPRDFSPNVALSSRPGLKDESHRLLLTMVQTLHSINQVLPSKFGWSVVTLTDGEADVVSSENLQESKRFLEEELLHIQRTLGSLLGDDAPDQSGASNTTSPSNIPHNRVGSPVEYHVTFSETPEVKSVLHNRDRYRLAFYMTALLDLARDVLGLTETILNTPDYKRPSSVWLASLRLLWVNRQDEVDIAADGKSVENDLVSEEERPVDELKEYQDMDFVTAMLHQSHSASSITGPKYSIQRTWKLLWNQHRVVKARVILSRAMHNIKHSRHVLFSIKLAGGICLLSVPAWMPPDNSARHWYENSRGGWMVVSYMFVLEDTTGAILKVGFLRGLGTLIGAIVGYVCTVIAKKNAYGLVVLATACSVPISYNVLFASLPGLGVATGITLPPILFIPYLGLAEGQSDFYLAWNRFVDIMIGTAAAVLVGTWIWPVHARVQYFRAAARMLAHLTEYYLRMSRDLVRSSLVYCVDDKQYEQLEAKLRRDVQLARALVAVQRQEVSLLPRPIKLYSEIIDASERLLELLIEIRILRFGVPRKETVLDVLPIRRELISTVLINLWSCSHAFGSRSPLLQFLPSPRTPLSELMDVTEEHARHLLALRKQAANSSVGNEGNVQAPGVPFSTGSYQAELAVLYGMAENEALGEMCSILEELVAAARTLFGTQAFLETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZG6</accession>
    <name>A0ABR3BZG6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616002.1">
        <property type="nucleotide sequence ID" value="XM_066755716.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988015"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12098">
        <property type="entry name" value="DD_R_ScPKA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 8" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="203"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="337"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0253781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="466" mass="50670" checksum="E6BE83F4060AD978" modified="2025-10-08" version="1">MSSWTDILNELNRDIALDNPTDVLQWGADWFQHKLRQERQGSHASTSLPPHALSPFSEMGPSDSPFGPTARRATVPTGSNLADQPLFSTPFGASSGVIRSDDRSPFSEGGGMPFGNSPFGETSHSHGAHDDPPIPSYALGRRTSVSAESLVPTSHRAYGPTSGLETTMEEDEATPNINSGTPVFPKSEEQLARIRQAIKPNFLFRNLDDEQEADVLAAMKEVKANAGQMVIEQGAAGDFFYIVESGKLDVFIQREGQILDLEKGDRPGLGMKVAECSEGSSFGELALMHNAPRAASIVSVTPCTLWALDRVSFRTILLDHTSRKRRLYESFLSEVPILASLQPQERAKIADVLESRTYNEGEDVIRQGDAGEEFFLIESGNAVAIKTDEDGNESVVKNLGQGEYFGELALLNRRKRAATIRAAGPDKLRVAALGEQAFTRLLGPVKDIMARSVSERYGFSTGRGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0F0</accession>
    <name>A0ABR3C0F0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101441</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616283.1">
        <property type="nucleotide sequence ID" value="XM_066755997.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988299"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF530">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0271350-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="170"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="546"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="618"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="696"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="811"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0254062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="887" mass="96403" checksum="4A9B6DE90635DAEC" modified="2025-10-08" version="1">MQPQQHTHDNNNALPAARPQPLHVHSPTIPPPNRGTRNLELVQGPKVPLTAPLPLRTAEVRSPNRRRPSPLVLGKPKEADPEDWQIHQERPFTASPGASDEHSLDNELQDLSKLRKAVRQNLLARPMDSPLDLSDSDLPAFNTPGRQSFASSSSTSMESIPIEQVFDQVENGSVLLVDTRPMAAFLNSHLPNAIPLSIPTLLSKRFQKSQSQSSNSGISWGTLSPFVSLPSARERWDSVDQDKVEVVLICHGEEGRVVEGILKSLIDDRVKTVRGGWAAVLNHARARRTLVSGQTLTWHNLDVTVPETITGKPLAPGPSSNMLPPKSAPPCEIPLPPIPLSPSLSLSPPKSLNHHPSLPSLRPPFAGATRDLPSLSINASQASQRRTPKLSLNLDRPLKSATFGGYHDIPPTPHGSLCTRTRPQRSPGLSLNIPRTPFQSQQGHIQGRIIDDSRLNGSGSIQTRAHEQSRFPPSSSTFGDAKQIENEGEDMAPNLYDGPTPRARIPHDPDKSQEYGARFYCSPSSVDSTLPPSSPPPTRPAVAPFNPSVILPSFLYLGPDIQCESDVQCLLKLGVKRILNVALECDDNQGLNLKERFKYRKVGMRDIVEENGVGKGMRDACEFLDDARLHSAPTYVHCQAGKSRSVTIILAYLIHANAWTLKTSYAYVAERRKGISPNIGFVAELMQWEEKELGVKQSGGVHGDGNGRGKASGGGGGNGGSSRHMEDEEGDDEGRGKTHLRDSLPPTWSSSVDNYTRSAKVSSPVKGDNCGEEEAGRDGRIAVGDEREVRKNGVWVHHRRAPVDRTTLQPGRRVSKAGLESLRPFMITSTDPSSPSAVSANSGSIDNEHQINNGNGPETRPSPRPSPEMGKEGHAMTPAGDGPLRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0L9</accession>
    <name>A0ABR3C0L9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS1</name>
        <name evidence="8" type="ORF">I308_101553</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616394.1">
        <property type="nucleotide sequence ID" value="XM_066756108.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988411"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0254173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="259" mass="29371" checksum="C58C79629B21A130" modified="2025-10-08" version="1">MAVGKNKRLSKGKKGIKKKVVDPFSRKEWYDIKAPSFFENRNAGKTLVNRTQGLKNANDSLKGRVLELSLADLNNDQEQSFRKIKLRVEEVAGKNCLTSFYGMDFTTDKLRSIVRKWQSLVEAHVDVKTTDGYVLRLFAIGFTKRQSNQVKKTTYAQSSQLKEIRAKMVEIMRREAEGSDLKELVQKFVPESIGREIEKAAKGIYPLHNVYVRKAKIVKTPKIDMSKLLESHGEAMDANTGSKVVKSGEFVEPEILESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0P0</accession>
    <name>A0ABR3C0P0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616407.1">
        <property type="nucleotide sequence ID" value="XM_066756121.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988424"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0254186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="104" mass="11857" checksum="5E9E35D5205934F3" modified="2025-10-08" version="1">MSSPLSKELRKEHNARSIPIRKDDEVLIVRGKYKGREGKVTQVYRKKWVIHVDRVHIEKSNAATSPVGIHPSNVVITSLKLDKDRRAILERKGSKKSGDVEMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1H9</accession>
    <name>A0ABR3C1H9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616231.1">
        <property type="nucleotide sequence ID" value="XM_066755945.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988247"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0254010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="861" mass="93252" checksum="5DE87BA38AD06BBB" modified="2025-10-08" version="1">MIALTTPLPSPSGVSIRSSRHVPLLSLAPPALALGDELAVGEPGEENNVGEIWNVITRAADLVKDGERLENLAWRHWGQPRHASFSRRLSASSHGSASDASIQTPNEPSYFARVERRSFGGALQLLVEKSEGSFKDWVEDAKRALPQTRVPTLSVPEAPIANGVEIRLVEPTPVPSRVGSLGGSINTSIFPSREIPPMLKEEVEAEEDENSSSKIIEKRRRVAISPMTTNRGSASSPRRKGKFFVQSSPSKGSASDSSLPSPVTNAALNPPRRTTHKRQSSCDSSSASTGHRRDSTHVSHRRHVSLTTMRGKFQAEKRKVAENMAKKEEENLAEEESGWEDEDQGEENEENEAQDDENWSDEEEGEEIAEDEAEEKPLPVPSPRDGRDRKNKDPNRRRSSSRPRPGRGSVSQPNVGAALSRGASWHGDRSRDNLTMTRPTPPPPAPTPLQKMSKKERQAAAAERAKIEARLEAQRKREMFAKQQIFGTRPSSGLLASALQRGASMVNLPSASDDAGVVLRNSPTHGQLTSLSRSPSCAGPSLLRSKSAAAMPVQTGVSVTIPAGHISKVAGKHEASSQESQSKAKGSAELESEDEDSDEDDANYLNTTQTRQKLAALNSKQETKTKASVAVVDSQQDVESAPAAASSAAQALPVGPRLNEFGVVEPMTPTTRRRNIIMAEMSESLRRNVVLEREKSSGGLSRILSGGATRQRSAPSMGPSHRSAVNLTQYAQGQSLEHQPTARPSQSSKDLSTHSQSHTSGLPPSAPDVRRRPTPNVLGGGNILRPLTRVGTDDELSAINRTQSTGILESGHRSRETTLPQPQAPTMIRSATDGNNMQGGREKREGKRINLMDTSYRIHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3P7</accession>
    <name>A0ABR3C3P7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100063</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616543.1">
        <property type="nucleotide sequence ID" value="XM_066754642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986921"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="171" mass="19177" checksum="E008D704A34EA8F0" modified="2025-10-08" version="1">MPQNLVSPEEFLTKLSQCFSDPSSSSSVWLTHKRLTYSDDADVQMDDGEGENGGEGPEHEVLIRCTQGDDKFSARVPASSVPSFHAAYGSLLKTSMAPLMRKRDKKKEKARAEALTKKRKELYVDVVIGNEGKRGKGRRQRQRKIAAQKKKEAERERLELKQAQQKASGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4F7</accession>
    <name>A0ABR3C4F7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616795.1">
        <property type="nucleotide sequence ID" value="XM_066754894.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987180"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="526" mass="59359" checksum="0112279D65394FF0" modified="2025-10-08" version="1">MPSQDKPQGGYDSTPLTPSTSRTYTLRITFHKAANLPVADFGSQTSDPFILAQATTSHKLRHSQDPYLRFRTNTVRKTLEPVWEAPWVIAGVPEDGLKLSVRIYDEDPKDHDDRLGKLEINTGSIDEKWQGFKNKSFKVKKTGADLRAYALRWTCVMLAGHDLHAHVVISIEMLGRTKREMGKAYTINGFWWKHYSPVIGRLTGTKARDDQGVERYNFQANEIQLIGPVPNELYHRYVDFKPFVSGMFTAKGIRGKILNRALHHQHERLYNYDRQTEYGVFPETEEGKDPDQDVTKKFLDLVHHDQGARIFTFIITLDGLFRFTETGKEFGIDLLSKHTMHGDVNIYIAWSGEFMVRRLSEPSKSPSDPSQHTHPAEELPGGPPKSSPPVDPAEYELIIDNDSGTYRPNKDLIPIFRKFLERNLPGLKIVVMACDDDKLQKMKDEQRKTKLKEGDGIVYGQGSISSLASGSNASISSSDQEGLNERARTMQEDRGDSAPSGSKLEKGVEALENPKDTLTNAIGKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4J7</accession>
    <name>A0ABR3C4J7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II elongation factor ELL N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616794.1">
        <property type="nucleotide sequence ID" value="XM_066754893.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987179"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="73445" checksum="0946F01C0BD2FAD3" modified="2025-10-08" version="1">MPSLPSKGGVPMLGQAGPSRQAYLIKLPEDIISALESSQGASVTVGMDGSVTLNVPDQDPMPLDARPASTASEIHRLSSGPHPTLKLAALATTRLNIPFSSTSTARAADKLRTQTDALEKQRKERALKVDGIKRHTDRIASGTTSAPMAMTASAPGAVWGSGTGTGSIPLKTRVMQYLAMGETTQEDLCRRMGGDEQNVMRVVKVVGRPSKAQPGSWSLQPNQYSKIKLGAGQWPYTYAEQQQVIQLAHAAFDELDLPANAEERMEFEKKEKDASNAFANRSSDESEKNTPQLSNTATLQSNAVTLVREREKARTESPSPVMRQKVPTKRGPQSKIAKERAKFVAERQRAGTGSLPNIKGPNGIASPRLGPTASPSVSPEKKDSSKYENGEYKEKEMVRGKERKDEKEKEKRREEKKDREREKEKSREADSSTVSKAKRSKTAYDYSSDEDAASNQIEIKATKTKGVSHKKIEDSPREKPVPLAEIVQKREKRGRKVDYSDSSEEEGEIRGRPKAKIISDDAARPNKHKRRDSESRRKPSQDRNDNNKRDAEGRKIGDNLHTPSQQPKPSRETSLHRSPPEMTANLASRRSQPADPEALRDRYEELYPAYNLLANKLSKIHQMAESGEEVGSSEAEIKKMVGKWERWHKELTEIRRWFGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4S7</accession>
    <name>A0ABR3C4S7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Golgi-body localization protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616894.1">
        <property type="nucleotide sequence ID" value="XM_066754993.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987280"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1347"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="2">
        <location>
            <begin position="1464"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1878"/>
            <end position="2297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2298" mass="258583" checksum="0C4EC163EAE606E0" modified="2025-10-08" version="1">MHFLPSFTAVSLTLLALILSSLVVRLHILPLLLRTFTQVRVSSFSLLSVRGLEWRTKHGKEDIIPILRVERARWTWGGIKGDVTGLFVLRIEGVSWRVKKRPSGDTKNEGSSVKHRPPGRLSALKSRLITFILRLLIHHYPSVARLVSIQLINCRIIFDDLDGIELTWKELGFGVKVEFRGVAEEAAVSTAPKRETPFRSSSSVSFRDEYYISPSLLPTAMSTPSRHTLSPPSSPTTHTSFAFLPSPEPCETPLPLSSNKKPQKTHRLSNARLFHSRMSTTANMIWTRATGRMYGSVSFNVYIDSIRCIDPQSSPAPSAKPSMPDLKSPTAHRPQFISFRPLKRCHTVYNLHPSDAGVSTLAALDERSSVRLSLGFGPKKGLLCEDTLSAAYEMGKLRTSVEAVEKVKKLLHNSRQNKQRGGESKNRWSTHGAARVMLRAMQSIKVSFSHITLLHHLHAPSPVSPSLPQRPLSNISSLDLSPSPMEDRYTIALELSEIRCALSSADSSNDDRARNAFGTNSSPESIIRGVTVELGWKSIELQCIAPGESSNDKSQLFAIRQAQVIVFSSWRPEGWSREELLFANDPNIALVVCQAYVASVDCAGDLQLFHELEVAWKTTHPKRSASRPSPSSESSAVSRKGSSGWLPPRLRMVLDIGDIMAVLADRVSENTTTLTLALDGVQSSCYTSFSDIIARRRDGAATKAAFKEEEELQKRREESDDVDFTMHPSMLPAALRRRSTANKAELRDNLSISMRCDATVKVEPIRVKMTLSGHKVYELAEIGSIYGTINGDVLGRLTVEPDGTELSSLDWSSISCGLDVGIQEGIDVDLWKEEVVEALIGMGETHQKRPKDDRQPPPSEGEKARILDKLPSGMSARFSLGKINVFLGVRDPNPECKLGLTRGLWFRTALKLEYAYHKTVIQSLPWRHTLTVPRRAKLRLPEDITTQSLAFASKLRPTGGSAALISMNTEETYFQPIFNGERFIRKGGFRKGVLRKDPPKTREDDEFVGWGFQRAKQLRAMNEGTFANNVPPFEIRDTDQAQRPWLRIPNSHTSFVAQRSKSDSEIGYKITTRMESPTLISDLSHIYCHLLACLMVKRVSEAWRSEPSKPQGSYSTLPNNNLNLSIDISIPSMTAHFAFPLQEQLFMYTSGITLSKQSYKGAVITAELLLLYVPSPRIIGSWEELGRIKQFAVAFSDPHLPLVISPRIESLRVRIPFSYKLNSLVLNINVTIKACKLLFRTTSGKIPFTTVYKPLAEQPKKVPTFSFSVGYISLEAKDDPVETSLNLIWRAGLVEQAKRNALEDNFAKKLLLISDPDTQPEIQEDTKTGGGRKVMVLTKKHTVDPERARWALDLLVSQSWVRRIKAAKYEQARREGLALQAMSGSGVNIKLPIRVVGSSRTAPLFRAAFHEVNLVITNPGLDRQQIIDYMGKVSAPFSDDVNFSLMIPLDIRWSMAEAKCTLRDYPLPLIRVQRVNKNEQRPAFYVETTMIIAEELADDDSVMHVPVKVIPEGCGHKDASSFVLEIAKTIMPVKTYAEPKFKISTKKTTEFTWGNSYQPAIQDLMKVIETLSHPPRDPSPKVGFWDKFRLVLHWKPIVDFVGPCHLLLKGSFDPYSVSGLGSGFCLAWRGNTQLLIDQPNADKEAIQILADELVVAIPDLTPFHDGAAIGNNRNHRHEHHDRAHERDILDDTDIVPLERRYTKPCAQFVGGVRVGFGFRFERTCRPWSCQHGCGETENLLHRQCREFTFLQHQQVILRSPEAIAKAEKRLGRKIDSYDGFRSDFIHFSVSLVAPDGNGFDHRKKEEMPDSVNSLHFAPKASHHFLSWWKLFSHQMSLPIRHGKLFPDSPPPSKKFGRSLGTIKVSKDHSTTGKSESLGIKARFGRLRADAHQRAQEKIERHEKLGRSTVVVHKPFYAADILADDLKVKGVRAHFVERIKDDDTSSSDPLPRASALSPETRHWYNYCDFIDVDRKPSDKDPRIELVDFGDCPYLFYCKRVKARASTSHDDSGSQASSSLGVESSKFGHEATHHCYLGMADCVRDAQRSITQDRINELQARLDSYPPPQENDNQSDRAVTLNRINILVKHYEDLQKETRHLSDETLEYSKQTTTTTYKGPQSAAAFEDMIHIHGPRLVLTDGSRNIGFKYLYMMADRKKEEYYTSYASLRGILDTYQQRARRRQRPETEIFEDEQTKNASADQQMVNDLIRWLPDKPALDNFHKDDNAEEASVRAHRGLPDDCDVKPKRHVLVFKPQIALRSESDPNAIVLLSAEEFSFKQFKVIDTNAIDDMMADVLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C687</accession>
    <name>A0ABR3C687_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616937.1">
        <property type="nucleotide sequence ID" value="XM_066755036.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987324"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="1">
        <location>
            <begin position="44"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="191" mass="21519" checksum="5C554CD62297FB0A" modified="2025-10-08" version="1">MDILDEPLPGHMESISAFRTLLKSPSERVACPDSIARPVEPDALQTSIIESWKATEPSRESRLRLLRLLSDLTYIINSKYKGYEEGGLKRYWVDVFGSVSWAGDTGHSGDLDLIVLDRKLLHGYAPVFWRTPPGEPLNTPTSHKRNNIPTPLKHLLRFESIAAASTPINKFKCRDQECDLNVNDLGGWYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6W4</accession>
    <name>A0ABR3C6W4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617162.1">
        <property type="nucleotide sequence ID" value="XM_066755261.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987554"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="582" mass="64107" checksum="C9BD071D1905CDCE" modified="2025-10-08" version="1">MPPKRPLKRRSEDEGRKQTKRIGKNKREQTYDTYDEALDGGVEMEEKGERYRDGEKAQRFYERAVELYAKASKFKETYDATYNRARALYTLATSFLLPPSSLPLLRESITLYQHATTLSDSPLLLMDVAFNLAQAFTTLADIMDDLRTTDDAEKDEAVLKLRNDAKVTLAEVMDGQEAYLRTVVAQGREDTAEGEEVVEHIEGGAENQSMEVDVGDKEDDGDDNTSTWETHLPTPSTYIDTVLTLVDLHLLLWESTPTPQPPTEEEQIAVRVILDRAASIAPSGRQAELDLAEVKVLLTMDRIIWDMYKREAKAGSGIENSLDGAITAIGAVLTSLDAVPAEDSTVRPEILTTMADTHVTIANRLMLLNTQLPPGPAPLAQSAWAHLTQATTHLTSAVGSPTDANTPREFKPSVFLSLSKVSLARAKLASLNDTAQKNIVQLFDNATTYASRAGETLGWTFLRVGPAPPSVGGTLNIGGSSIGGKDLPYPSGWDSELLGRNIALQQVRVCLYATRTELLPAESKGQYKGVLSKILEKLGRMEEGERKVRGKDVERWLGEVEDEEGGLGEIEKGWWTEVTARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6Z4</accession>
    <name>A0ABR3C6Z4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617192.1">
        <property type="nucleotide sequence ID" value="XM_066755291.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987584"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="353"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="688"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="804" mass="86891" checksum="B32CB3B8CC0D4A8E" modified="2025-10-08" version="1">MAIISDVDYMLQAIRLSSLRTTDDHITPRIISLDPTFAVNPYINASGLSDIDRWPEIKRALDSPPLEEEYLSGSAPGMRNGDAEGPRRGGGLNYTQTIMGPGRTGGAGMRVSGRHAIPGELKRGQAVRADSSNSITAPQSPTYKGKESFHRLPEITTAGDVFSPSGRPRAGSAPAPAPLQGSPGHIASSMLSTARDLGVDAPRGPFHRALSSSQMSSGSGLLPDGVLTMTTPEDRGSSIGIEPTIGTQTVEGRMVGGLEDQGSDVDEEEAAEADVREGGREATAVPDSKRASVDTVSTTEHLDFTPVPLPQGQNLPSQPSALTAALNKFIPHIVSTAPHDSSEALPPVPATIINPFYSLYSTVAAPPGVPSESLELYFPHSKNPGQPVVANVRKDATVEEVTGFGLWKYWDDGREPKLEEEGHKEERWSTVGWGLRIVEDDGEVDEDFPPLDRESKISKFSYGQFAIVEATENQIQQNILKAPTITRRPSRVLAVPFSARPMVQASAAATRPSPVLPQSNQVGSAAPSSSSPEFAPLSTTVTTTNMGQGRGLGSTVGLSSTQSDVVRLRVRVTASADVHFTTTINVPADMYIADLTEVLCKKKRLQMPVTDWVLCLADLTLALPLDRTVASLGFQTDLALVRRQWAMEHGLRIDDRRGGDPSASIFKRQSEPAPIQRFGPGLSDFTQTYKKYTVQRKIAIGRHERVLAIDGDYIHIMPSESRAFFDSMKTTSFHISLVAACKLTGRGGGFKINVWRDGAQKRYEFEAENQRQAVDIVSTIRQLMKTFAAERTSMLPPPRATLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C7L1</accession>
    <name>A0ABR3C7L1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616766.1">
        <property type="nucleotide sequence ID" value="XM_066754865.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987151"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="112"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="460" mass="50534" checksum="E3A977E49F16C1A2" modified="2025-10-08" version="1">MWSAYITIPSSTESKSATLQGCLSAQPQGSDLTLLFSAHLYSSYSPIPAMSILRVAPALRAKAVPRVASLVSKRNVNDLSITSPPNPSASVRPAIRYGPPTGGRSSDSGRTVTVFGSTGFLARYLIQKLARQGTQVIVPYRDEDEKRRLRPCGDLGQIVPLEWDARIPEQTAECVKHADVVYNLVGRDYETRNYSYDDVNVKVAQSIAEISANMGIPRLIHVSHINANPASTSEFYRTKYAGERAVRDAFPEATIVRPSQLFGHEDWLLNAIARFPILAKLNNGNTKFFPAHVVDVAQALNLMFDAPVTSTASTFVLPGPELYTYGELEKLVSALTLRPLSSAPSLPKPVAKFLATLVNRGLWWPTISPDEVERMFIDDAGADTLQAHSPGPDGWNAPPKLNIVGVDGEPVKSWADLDMQPDTIAEHAIKPLRRYRSTVNYDLPVETHIIKSPKQYHVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C855</accession>
    <name>A0ABR3C855_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EXS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100747</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617213.1">
        <property type="nucleotide sequence ID" value="XM_066755312.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987605"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="7">
        <location>
            <begin position="244"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="528" mass="60249" checksum="ACD04634556FE397" modified="2025-10-08" version="1">MDIDSPPSNTIPDPHSHVTLPSFSASFPLPFRVLFLVGLATLLWALNLHVLAALRIDISAVLDLRDDPGGDGHISLDDGDDGDERAEQGILSPRVQPLALTLNEDTPMRPANTRIMRPSANKLYGPMYKLFLMYCGWVGTAWVLFRYLSGEEEEAMERWRVIPGLAMVGVVAAVAVPWRGVLERERAGFRRAIKRILLPRINDPIHFSDVILADILTSFAKVLGDLWISTIQIWCGGITQGRVSQRGWSNYITLLMVSLPYMLRFRQCLLEYYQSSWQSPRPLANALKYFSAFPVILLSALQKSVVSDIASQKGISVQELTEQHDRWFGEHRLFRLWLLAVCVNSMYSFWWDVEMDWGLALCEADTWLGAKKEGGGRHEGWIERMKKMFRKRRDVDHHQRSPCPTPSPFNTSPPVSPTRIGNGSGNGNGSGSTKPFFAFGLRSTLLLPDPLIYHLFTIVDLILRFTWSLKLSNRLHTISEVESGVFLMETLELVRRWMWVFIRAEWEAVKMKEHRWGRGKLVWEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHU8</accession>
    <name>A0ABR3BHU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial ATP synthase epsilon chain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610792.1">
        <property type="nucleotide sequence ID" value="XM_066760967.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993398"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8214" checksum="515B742C8B800027" modified="2025-10-08" version="1">MSSTWREFMSWNKYTSIASRALRQALNETDRVAAEKRAVIGVRYQLWENGQSGESNYVVPPPKQAQTPGNPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BII9</accession>
    <name>A0ABR3BII9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610976.1">
        <property type="nucleotide sequence ID" value="XM_066760704.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993126"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="119" mass="13031" checksum="ED6962D244FFFA41" modified="2025-10-08" version="1">MAESSPQSPSQLFPTQPSEEASQLLSEEQASFFLTLPDNTSPKLNAPAPSLDENSSSMFEQKRQLAELLKNFSYQAPTSLNSNTSISPLRLSKNPSSNGSVRETEADMDASFYPSPVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIU1</accession>
    <name>A0ABR3BIU1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106628</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610876.1">
        <property type="nucleotide sequence ID" value="XM_066761051.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993483"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0240377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="411" mass="44767" checksum="589641ABFF7EAABB" modified="2025-10-08" version="1">MGVLRLAVCISGVYAAFLLWAIAQERLSKPFPSVHPHPHQQPHSLSDPPPGDKFPSPLFLNFAQAVASSLSALCYLSFKAWREGWKGRGLGQLLGLKEVFGKSEVVLNGDAKANKEASESDEKTEIAKAAPKQPKKSLLALLVQVSIFQTIAGPIGFLALRHISYPTMVLGKSCKLIPVLLLNVLLYRRKFSPHKYIVVTLVTVGISMFMLFAETSKKKKGGSDSMWGLVLLLVNLFIDGLTNSTQDQIFSSYPSYTGQQMMFTMALTTQIILLPLLLLPLPTNPLSLFAHLPPPLGSSVPTSTLSFSPPAALESVSFLLSHPSALAPLIAYALLGGLGQLFIFETIQHFGSLTLVMVTITRKLFTMLLSVVVFEHKLTNGQWMGIGVVFAGIGVEAGIKRRDVMKKAKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIU3</accession>
    <name>A0ABR3BIU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_106406</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611107.1">
        <property type="nucleotide sequence ID" value="XM_066760835.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993261"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="445"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="978"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="667"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0240608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1071" mass="118147" checksum="691CDB30870F6A87" modified="2025-10-08" version="1">MALSPSHAGQTAPQWRQFTFFDVEDVKDEQDLAQSPRAIRQLTPPVVITTTAPKSPLSPSLIVSSSRNISILDKHFSVERSFTAWEQNGRATFLLEAAGLLVAIGEEEGSLWPLLKVWDLTKEDKKSAERRPVLLRSVRIQHGQRPHPVSSVALTSNLSHLAIGLGDGTVLLYRHFLQSLTTSSSLTSFPKARVVHESHEPVTGLGFREHPPTDKSTPSKSSSSHGFSLFIVTTNRVLSAPMSGKGETRTIDDVGCALGCAAMDSQRKEMVVARDEAIYLYGPDGRGACLAYEGPKSSISVYSHNLIITSPPFYPSAASASATVRHYAKPIANGESGSPDIAKITVFDLDNKVIGYSGTYSEGVRDVFSQWGGIYVYGGNGKLSRLDEQSTQTKLETLYRRNLYTLAITMARSQDLGEAGIADIHRRYGDYLYSKGDFDGAMGQFVKTLGFLQPSYVIRKFLDAQRIHNLTTYLQELHSRGLANPDHTTLLLNCYTKTSDRALLDQFIRTEARRPSSPSPGTGAGGREGELPFDLDTAIRVCRQAGFYEHAAYLAKKFDKHEDYLRIQIEDAGKVDEALRYLRGLGPKACEANMVRYGRTLLQHEPEATTELLIDLCSGNLGKKKAAPEVDEKADGTAAGSGVNGSGPAMFSYLGYNKVTGFLSGDIPSGPTVSEDEKPNGAQDGSDAAKVGEDEKEDATPSYVPASPRQYFAHFVDHRELFIHFLESVALKLWNQKVDPSSSNSSTVSAPKKDMNTPPPTDPTIIDQTAVWNTLLELYLSSSAEQSKQKALALIISDSTPYDPMHALVLCSSVGFREGMVRLWEGMGMYEDVLRFYMEEGQEAENAQGIPASSKVFTHLEVYGPSYPHLYPLVLRYLTSSPAILTKHKEELSKILAKIDEHQIMPPLGVVQLLSRNGVVDIGSVKEWLRGKVEENEEEIESDKHLYDSYRSETAAKRKAILDRSNVSQPEVFQVTKCAACGGQLDLPSIHFMCKHSYHQRCLPDSDPECPICARQHSVIRELRRNQLRLADRHDLFLEEMHQAEDGFGVVADAFGRGLFGREGIDEKIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ32</accession>
    <name>A0ABR3BJ32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611192.1">
        <property type="nucleotide sequence ID" value="XM_066760920.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993348"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="290"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="478" mass="53549" checksum="6EE4A22B1DDD0915" modified="2025-10-08" version="1">MSQSSWPPELKTWVQNCLARATASNKNAVNNELKKVLFEAHAQGTINTTDWSKVELQALKSQAQRTSYTPQPAYTVSSPALSASSASTLTKDTASKKKKKKNDGTSTSSFPSPYLFSGSAEEEEAKARRAARFQKPAATSSSNHAAASGGIGTWFDDARGSGGLGMVPGQVGKRKIMGKGNLGYGGAVVQEVDPNVIDWDAYTIRGTSTKLEKSYLRLTSEPSPADIRPLPVLEQTLELLKSKWKNEHNYAYALDQFKSMRQDLTVQRIKNDFTVKVYEIHARIALEAKDLGEYNQCQSMLRQLYELGLHGHPEEFLSYRIMYLLHTRNRSDMATLLAQLTEAEKLHPAVKHSLDVHAALSTSNYHRFFRLFITAPNMSGYIMDHFVERERMSALAIMSKAYMTLPLDYIFHTLAFDSEDEAHQFLTEHSAAVYTNLHTSKGFRMTLQDLIWDCRKAHAACQKGMEKYRVVDLKGQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ49</accession>
    <name>A0ABR3BJ49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2',3'-cyclic-nucleotide 3'-phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610828.1">
        <property type="nucleotide sequence ID" value="XM_066761003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993434"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012386">
        <property type="entry name" value="Cyclic-nucl_3Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141:SF1">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07823">
        <property type="entry name" value="CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25337" checksum="08229CF75305FF22" modified="2025-10-08" version="1">MSDAKPKQSSSLSGYAIWLIPSADEKQHYQPLINRLAKLGDGRSDDEKADSPSFEPHITLFAFIPLDTPIGQISDTLRQVVARVNTEASESSKAGTTIENGSGLKDFVLELLPAQSGTSYFQSVLAPVKPTATLLSLREQTVAAFSSSGSSPPSPSLSPLSDSKEKRGKKDDYFPHLSLFYGDCTQQKRDGIASVANKDDPTLGSGRARVTIKELGIVRCAGKVEEWEHVDSVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJK6</accession>
    <name>A0ABR3BJK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610993.1">
        <property type="nucleotide sequence ID" value="XM_066760721.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993143"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="360" mass="40065" checksum="F6597A5181061DC2" modified="2025-10-08" version="1">MDDQDLEIPVEHCTAFGQLVTGPPGAGKSTYCHGLHQFLTAIGRPVHIINLDPAVPDPPYPCSINITELITLESVMEEYNLGPNGAMLYCIEFLEANFDWLVERLDDVLAEEGGNGYVVFDTPGQAELWTNHDSLKKVIEKLVKMDYRLAAVHLSDAHYITDASKFISVVLLALRAMLQMEMPHLNVLSKIDLISTYGELPFDLSYYTEVQDLSYLLSSLDSDPRTTKYRKLNKALVELVEGFSLVGFQTLAVEDKESMLSIVRLVDKMTGYIFIPSGDLEGTNAINTQALFGSAMSSAKLTGRAGGDVRDVQERWMDNKEAWDEWEKEEWKKEAEIRAKLGAGISEGTKDGESTESRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJQ6</accession>
    <name>A0ABR3BJQ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CLU1</name>
        <name evidence="2" type="synonym">TIF31</name>
        <name evidence="5" type="ORF">I308_106011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611221.1">
        <property type="nucleotide sequence ID" value="XM_066760460.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992866"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Clu" evidence="4">
        <location>
            <begin position="399"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="755"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1379"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1427"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1427"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1445"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1460"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1484"/>
            <end position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0241839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1500" mass="164235" checksum="F32CB4AAF858B5F5" modified="2025-10-08" version="1">MSESAQAAAQNGQAEEQQLQQQLDEQQQLEEQQQLPPVTIRIPSPTCSRTVPRPKDSTEPLDRITLYPQPQETIQDIKLLINDWVGAYWLGPYSLQLPFVKGEDGRGKIYSKKKDFSEVRAGEKLNEWLEVQDAFEHLQEGEERVLEAVREPYGELSARQSIIRLLELIAPSGTTANTTSNPLGLQAGSTIFEQVRDGVISANAETTYEEVEVSLPSGRKGKGGKKELVKVKRAVSGDKAHAFADWKEWAPASFGSLAVASDPVEVAPSLKSIQISPFNPPPPHLRQKGHELYLQVSLLEGEVVTLICSTRGWYVSKSNVNNFDPSPRPSADGSIPAPTHSLIDLLHSISPLFSERVSKLPPISLDGALADPISTVAIPQAVPAYPFLASAPKPAVSPEILRTQLAFLHTGAYGPDLVDAARDWNEEIQGIRELPRGTMQERVFREKMLQKVWAEFDQAAARAVQAVSKGDIPPINPAEDPKAHMYLQSNIFITQGDSDALDTYAHLGGDAAMRISHGKDAAGVRLLNKVDADGLYLLGHTIVDWQGRRWICQSILPGIFSNRRAVEEEKAQAEAEAETETVDAVEGEQKKEDWVDVEKPTEKSGSETESDNPMMIYGLDSERPTSIHWDATTHTLLSTIATPLRLAAHSIKDGEGKEHEFYASAEVKGLKGQDGRRYLLDAQRLVPVDVEWLEKDITGPLVGPKKDDDSTEEVVEYPHRLVMLRPELIEQFWESELKRWARGVAEKAQAKKAEADAEAAIAADAEGEKKKEGEQTETPQEDQSPAATAAAAHRAEEDRPVDASLIGDIKQFNLSFNPDAFVEQPLPEAEGQEGKPEVKATITDESDPSVKAVRDAGLFLRQIAIPAVVLDVLTGNTSGVMDGESLSKHLHQRGVNVRYLGHLASTIIQFSTSKDGAAKEPSGHLAALQSIVLQEMVFRAAKHILRELLCPLRSETATDAISHFLNCLLGSSLNPSPVASYTPIGINANEPEPAYVKLTPEGLRAQIIKEIKSRFRWTLDESFLESGLRKKQLLRELATRVGFQLVQREYIFSKDQEEEEKKEEDVKSKEKKKGSKAGAKAQTVKRTTTFEGEDVLTLVPVIKSTAPSVSVAEEILEAGRNTINRGKIEFGLDFMLEAIQLYESIHSVIHPEVASVYNSYAQAIHQIARLKIQQIAAQENPDPEQPLGVDISGALRFQRQAVAIAERTLGVYHHETAGYYFQLAMLENLEGNAQQSLRYFRHLLTLWDVIYGPGHPEISTILSNAGIVLQSMNDLSLSLSLQKQAYESTLASFGPDHIQTGQSLHQLVQGHFLAGDMASALETAKQAHEIFKARLGEEHSQTKEEAKNVELLTAVIENQERQKEREEAVKKEATERLKMAREKIGGGATSTSRPTGIRRLGASAGPLPQGVRVVDPKTLAALAAAAGQGGNPSANAAAATAGQGEQPNGESTEIPQIGERGTESLEELVRYIQGSAPGAGGSAKRGKNALRGKRRTGAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJY9</accession>
    <name>A0ABR3BJY9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611494.1">
        <property type="nucleotide sequence ID" value="XM_066760190.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992595"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="55"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="246" mass="26757" checksum="EEAD750C42FFF9E4" modified="2025-10-08" version="1">MTRNATSLRPSLTHILHNPLARSHIHMRTSTSPADIPTLSQLYHDQNLKSATAKASKYAFNKQLNDRISIWRGDITKLEAEVIVNAANSSLLGGGGVDGAIHQAAGKQLLEECKTLGGAQTGETKFTNAYNLPSRKIAHTVGPIYPSHSPHRAAQLLKSCYKTSLEGCRDLGGGVIGFSSISTGVYGYPIKDATHIALETTRQFLEQDNTITRVIYVVFSKRDQDVYQEIVPEYFPPGPEHGDGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK68</accession>
    <name>A0ABR3BK68_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611577.1">
        <property type="nucleotide sequence ID" value="XM_066760273.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992679"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="118" mass="12744" checksum="8765DB4ACDE39996" modified="2025-10-08" version="1">MFGTHRGGRVPSLLLGAPQRTLVYGESQPNRVLQSFFNNMWGGYWPPLQTTYGYGTMMSPYYAGGLGIPYMMGMGGLGYGLGASKYGMGMGMGMGMLYPYGMATTNPYGYTGMYGIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK77</accession>
    <name>A0ABR3BK77_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610974.1">
        <property type="nucleotide sequence ID" value="XM_066760702.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993124"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="293" mass="31077" checksum="9B824EFED68FBEDE" modified="2025-10-08" version="1">MSLKLQDIFDVKGRVVLVTGGGTGLGKAITSGFVQNGAKVYITGRRQQVLEGAAKEIGGDIIPIRGDVGTKEGCKAIADALSTKETKLDILINCAGVMRAYKTAIKNHDNPDEVEKLLWDGHDDDDFNYSNSININGPYFMTCALIPLLRKSDLRSVVIIASIAGLANQRAMGSVSYGVSKVTIHLGKLLAGRLHPLKIRVNTICPGIFPSEMTGKNDVGQGLEYDIGEGPSKAAKRSTVGRPGLPEEIVGPVLLLSSKAGGYFDGAMLTVDGGRLMGAGIHDGLRLPEDTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK92</accession>
    <name>A0ABR3BK92_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611586.1">
        <property type="nucleotide sequence ID" value="XM_066760282.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992688"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0242204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="351" mass="38295" checksum="63A75760AA6DC651" modified="2025-10-08" version="1">MHDSSPINCHCCQLTQKALYCPACLREGQHSQKLLTTAENETTRQAGRGLNAWRELRSDVASCEARCHQIKMDIVQRQATVSACRKRIAENNLRDRRESLSMLKSKPSPALSLRASIKQVHSQQQVITSRIIHARRVLVREAVNVFGVRQRSSGDWEIAGIPLPDPENFRASLSSKIKPQSTLPISNLSAQPSICSIIAKSTSKHKQFLVSFALLSFSVAYLAWSQDVPGIGIRGDVNDNDDVGVLFDEESKIPQGQSVSAKSSVTETALISPASILRLIHAITQSPTLGHRSHDPGGAGTLKHLGFGLDVSKLVSTILRAEELQWDVKGDAEAGDDILSEGWDLLDSGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKE4</accession>
    <name>A0ABR3BKE4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611644.1">
        <property type="nucleotide sequence ID" value="XM_066760340.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992746"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="164" mass="18255" checksum="4E02A741E0BDD447" modified="2025-10-08" version="1">MSDIPSQGTTMETADIVESQEGNKSEVTEKTLSHPITPPDIASQWLFDPFTNELCASNEGLKMCSGVNNGPENGEAHSPVLEPVEEEEIKPLASQAVDENEPDIPISQRGDEEDIVDEMKRREEERKLYLALYSALEKRGFRFLWGGQKVFQAVLEELTDQSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKF7</accession>
    <name>A0ABR3BKF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611659.1">
        <property type="nucleotide sequence ID" value="XM_066760355.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992761"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="41"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="120" mass="14098" checksum="8E0DA81CD8D299FB" modified="2025-10-08" version="1">MPIPLLRPLTGTVRQQARRGYASVLEQPPQKPAQELPLRLQAIKLYKELHRLGRDYPDPAYDFNKRLRRAFEKNSKVTDPEALKKQLELGEHIKKEVLSLISLKKFRHLRRAYHPNEGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKW6</accession>
    <name>A0ABR3BKW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611812.1">
        <property type="nucleotide sequence ID" value="XM_066759866.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992266"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="77" mass="9125" checksum="22EB14E5D630379F" modified="2025-10-08" version="1">MIRGSAVLNERRDDDEGFETKYTSTHRYASDSPSYVPHTSNKFRNRFSYLESCYTSTNRAIIPHRNNLKSIWYLVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKX3</accession>
    <name>A0ABR3BKX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U3 small nucleolar RNA-associated protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611443.1">
        <property type="nucleotide sequence ID" value="XM_066760682.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993104"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="993" mass="106752" checksum="C574D338D62A4CDE" modified="2025-10-08" version="1">MTIPLHRIRFYDHTPSPITAIQYTPLPLPTASSTPSQTPPAHPGDCIIARENGHIEIWKHVSDKQTDSYGNWVLYKTLPPTLTHPTIAQLALVIRDPLNCSTPSLNDLRLFTSSSDSGDLVERCLFTGKILQTYPIPSAPIWSLAVAPTHDLLCLSTTSPNLHFLSIPSPTMFDPSPSLGPPPPHLLRTDALPSRTRTTSIAFGPPTFTQLPDGTAEWRNTTLVTGNSDSSWRKWEIPAPSDGSRQGPNRVVLKGRAVVEKVQKAGRGGRKAAGGAGGQKQTIVWSIGILPDGTVATTDSLGSVIFWDPLSLAQRQHFRAHKADAMCLAIGPGGSTVFTSGPDQRVCQFVRARAPGAEWVLASAKRLHAHDVRALAVWPPYVPVPTTTNTKHGTSIVGGGGYAPVLASGGWDMSPTFTPASHPSSPSLPSPLSRPSQSQTQPTFESTHPRRMGYLSSGVLTSSSPITFSPSARLVVGKRDRGVGIWRVHPNENGWEKLLEMELRLRTTIIATTISEQGKYLAVSDLYETKLFKLVPSSSGLKPIRLPLLPALLSSPLLHHLNTQLTTQGCGSTSMVFTPDGGRVVLGLITGQVLIIELVEDEENVEVEVVKCFERKERVVRGRVIKGKNVNGNSNGVKGGRNAADDIDVSMADEADEQKSNSGSESESESESDSDSPSTFYSNGAHKQTQNEWISTLAVSEDGQWLGVADLEGRVEVFNLDSLQLHSTLPTLPHPPTTLSFPSLPSSSPYLAILAPTNTLSLYNLDQRRFVPLPSLGKGELEKFGNVLGKMQTPAMGMIWRPSRFSLSSSGSRSGGGGDGDGDGEGKALLWGTDYLVTLRVTRDMLHPIPNVNGEVTSSSMPNHWASPAATVSSVNGPVNGKGGESKSSRKKRAREARQAKASHGQGEEGGAGVGGELGEKKEEYYKIIGDRFKSILSVGWLAGSHQLRQQQLQQSQEGGEEGELEVGVVERPWGDFVAELPGVFWSGSYGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL44</accession>
    <name>A0ABR3BL44_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611716.1">
        <property type="nucleotide sequence ID" value="XM_066760412.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992818"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="58087" checksum="155C5AD52FDAED47" modified="2025-10-08" version="1">MSISKRPSLDLCLATLHELLYPSPILSLLLSALNLSAHFQLFANQLSSDAALIEALHEKHYYMVHESGMSEGEEISKGYLLDSSEGEKVKHIRYRKEEVFDASIRLRKHHIATSLAMVKRDPRQVKVLIDLYFPNIDPDDHSYRKNEHLFISCMKRSQARKMMEERKTVIQWYKDAVEVFDAHEPPLPYRTFFYGENSSLAHGRALSQTLLEECQEIVQEARDLEALMAGDETWQGKKLTISKGKGRAVRRYTMTDTVTDSKITNISPPLKPARQPRISLPTNLNFNLNSSPSTNNDRRTISPPSDSESVRVRTLPRLSFSSSSIRKTSSALLRGDYQAEVAGTPSRAPVHISAQKTGPLIEKKGTTSSPSSRMTYLKESSESPKRQSPHSEVTNKRVPLPVLAPSSPLSPRTKAEELVKFSKETEIQWAANERRAEEVRLRRSSDGTKVGNGSGERIEVGATPATPTQKPVTPSSIQTKMTAVKKKRPRQSFPLSGPEFSRNTVSGSGSAKKRPKIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL95</accession>
    <name>A0ABR3BL95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611933.1">
        <property type="nucleotide sequence ID" value="XM_066759987.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992388"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="33034" checksum="E2D6016EC3004AC9" modified="2025-10-08" version="1">MSTLAMGKSLIDPRYCCCAVPLVNAGIYTVLGEQAVLGAAIGIVVFATPDIVGASFPSFGGYIFAVICFVIAAFQPIGFIGVLREKTSTFKVYSLLNALGILAALICSAALIITSALRHDTAVTDCEYKFFSDTGNSSSTANQTLASESQALCSAFAWADVGIMGGLWVILLVVQGYFVYLTRVYSTSQVSDHKLYHSVYSENPEAFTMSILRSTRYNPGSVYNTMPGPDADVWDARPSMDSVQDVPAVHGGYSDGSQPLHYENNNGEPQNHPLHYKTYPSAGQQGGQYVFTGPGGGYVDHPAETRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLA1</accession>
    <name>A0ABR3BLA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611776.1">
        <property type="nucleotide sequence ID" value="XM_066759830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992230"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13298">
        <property type="entry name" value="PH1_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="122"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="360"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="605"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="681" mass="74672" checksum="4963D942CFF0C2E4" modified="2025-10-08" version="1">MSGSQQQPIPAPPPSQSEIERKLSFRSTVPPRPIDSPKKPRGILSPNISAHPISPLLTPATTSVGGLSAIAENKFGGDEEIVSMMELEDVEEEGEETVEGAESASEDEEAQDELQRGMEGQRVVMSGYLYKKQEKRRRWFVLRNEKLAYYKDDKEYSLKRVINLREIHTVAPVVIKKHPNTFGIVVPKRTFFVKAPSHAEMDEWVHAINEMRRRISEKEEETKRDHHPKSMSIPRNPPTLHSIDTVSPTNTTYMGPMVSSPQPAVFSPSSPIDNNLTSRFAKISLSSRSPSNQSIHNLQGSHGPSGISNVASRGVSGSSKREHSTGSISSADHFRSVRPPVSSEDEDELETPVAPADPKKVILSAYLMKQSKRRKDVWRKRWFVLTSSALAYSRSHMETKAQQVIPLSSILDALEVLDPASDGNESDRLSAHGHTHPVHSHSHHTFTHAQSPTSSSRQFMRGRLGPVSTSTDTRPSKDDEHIFRLITAKRTFHLCAPTEEDEIKWLAAFRALLEQQRGERSASFNVGGSSAQSSQQAQAQAQPQPQPQPQAQAGQGRRLSVPIITQQPPTPGQSSFSLGSSVQDPLTANTVPESPGPSSGVTPLSASPSASQVTSTATTTHSELPSQQSQPQDVPSAQSQMQIGGLPSSHTGQRPRSATYTAKSAVADVVRRFHAEKERET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLB7</accession>
    <name>A0ABR3BLB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105524</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611924.1">
        <property type="nucleotide sequence ID" value="XM_066759978.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992379"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045013294" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="21"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="306"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0243557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="468" mass="51654" checksum="E089BEB32397F823" modified="2025-10-08" version="1">MRVSSILLMPFVALFGLVSARSATGDRVLVVLESAATKDDYSQFWDSLQQRGFELTFKEPKSKDAELVKFGEAQYDHLIMFAPTAKSFSPSISPKAILDSQFKGLNTLYILSPQLSEVQREHLREYDLEFIPSDLVLIDSFSHPSGESASTVLLPPTECAISNGAVLSDTTLTGGPIAYPSGTVHSAGLNPYLIDVLHAPKKSYIGQDKILTADETEVENAVGGKKSKDAVQTGKKASLASALQTRDNARAGFVSSGEVFSNKYWGKTVETVDGKKVETGNAAFVTDFTRWIFQETGVVKVVSTTHFRKGETEPREMYTKKDDITFSLTLAQHVTSENGTSSWGPFHADDIQMDFTMLDPHIRTAMIEDKSSSPADATTYKAKFIAPDRHGVFKFVVEYWRPGWSYIRTSSTASVVPLRHDEYPRFITGAWPYYIAAVSTSVTFLAFVALWLSLGEGDRDRKGKKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLF1</accession>
    <name>A0ABR3BLF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611821.1">
        <property type="nucleotide sequence ID" value="XM_066759875.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992275"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="281" mass="31197" checksum="7D88AA7DF66ADE63" modified="2025-10-08" version="1">MPYRGALCSLPSYSTPYIEKKKKNVTEYDLLAALKPSEGRHWAHLLCSTWTNGVEYANATSFKQVEGIMNIGGDRWMTACSLCGQSDGAVINCSDCDIQFHVSCAWLSGLTLGFEFNLAKPGKSHGEIIIKFKDSEGVMSAGVWCKSHDLSGRVIHGIFDVEPDGGETAFQVYIGTYKSPTWNSAFPLLRKARRLELIIPSSLKLSSSEETEKKVEKCNSCGASDSPMWHKHNEGTVQYDAASAREAWRDTGIVSKTAEDGQGQEQQLRLLCHLCWFENRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLH8</accession>
    <name>A0ABR3BLH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611454.1">
        <property type="nucleotide sequence ID" value="XM_066760150.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992555"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="76"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="362" mass="40549" checksum="C7C72519D28ABF71" modified="2025-10-08" version="1">MDISSYTWGVATASLSMRPEDTIERKFAALQAAGFKNCELGFNGYMEWVRQQRPDLPASTAPHEWAEAGEPDPSDEEIWKALFDHVHAMLSLAKSYDIKILMLQPLNQFEGWAAGSKRADWCRRKAEKWMPLCSALGVEQIQANAKVAEDMRWLAQFSSELKPPVKIAYENWSFGDRISSIEHAWKIVQMADHPNFGLCLDTAHFPLTLGYGWNPRTGEGWTEADLQNILSFIRALPVEKIFYVELSDVLAPVVPLGQGSPFDEWCNNAKTSRGDRFLWAMVARPVPLIGRDAGRSIKAESDKGGARVVEALRVILEAGYNGPLMFEPFEALSMEQGNDIPTLYAQACAKAKRRLIEAIKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLI4</accession>
    <name>A0ABR3BLI4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611851.1">
        <property type="nucleotide sequence ID" value="XM_066759905.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992305"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="34520" checksum="02C0FE7427D0BE86" modified="2025-10-08" version="1">MTSFFTFSSVPVEIEIKLQGEEGRRQVEVKGEKDQREQCAVYYDGESVSGQVNVRVKDGKKYQHDGIRIELIGSIELFYDRGNHYEFVSLSQELAAAGELRHAENYDFIFKNVEKQYESYAGINVRLRYYLRVSMNRVSKEKEFWVHSYRMPPEANSGIRMEVGIEDCLHIEFEYNKAKYHLKDVIVGKIYFLLVRIKIKHMELSIIRRETTGSPPNQYNESETITKFEIMDGAPVRGETIPIRLFLGGFELTPTFRDVNKKFSVRYYLNLVLIDEENRRYFKQQEITIFRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLM8</accession>
    <name>A0ABR3BLM8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612066.1">
        <property type="nucleotide sequence ID" value="XM_066760120.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992524"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="136"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="504"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="546"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="586"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="626"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="666"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="720" mass="78367" checksum="9436ACEF2ABB6BE7" modified="2025-10-08" version="1">MAPTRCTPSSPPADLPRALGVRLSPPATALSPPTPTTPTSRSTRTEYTDVFAGVGMHPPTPAPSPDPHARTFDHGDAHHLEQVVHHDTQPAPHAIVAQYTALPPLRRSQFLSLLVPHLTLHEALSLSRKIEPLLRRDFLRELPWEVALHVLSFVDDPQTLARAAQVSRYWNTLLQDESTWRDFLLARHRIGLSVSHRNDQPQSRITFRDGGRIGKEEGNGWDVGSSGLAAVSNANNNRWGTLRGRENTLGIGTPTGTGNQACCIKRVTPFGLEKRVLNLSSGLTGLPPQSQPQPQSTPAPPLYSYKTRVKLAFLTETNWLTAGVLLAKHLSADDSVVTTLSFDESWIVVGMANSKIHVFSAVNGAWKRSLEGRAGHTQGVWAMVLVSPMVNPVQGRGQGPGQGREGRGAGSGAQASASSPNGWFGFNLPFTHPHAQTPTQAYTQDEQDQSGKPAEEDENETEGGNLCGSVRGWQGLKTSLVVSGGCDKQVKVWDLETGQCIHSLPGHTSTIRCIKVLPHRPIAVSGSRDYTLRVWDIQRGRCLHTLRGHTKSVRCVEVWGNMAVSGSYDNTAKLWNLDTGECLQTFIGHYSQIYSIAFNGSLVITGSLDSTVRVWSPTTGECLALLQGHTALVGQLQLSGTTLVTGGSDGRVIIFDLSSMSCIHRLCAHDNSVTCLQFDKRFIVSGGNDGRVKLWDVKTGEFVRELTKPCDAVWRTSFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLQ5</accession>
    <name>A0ABR3BLQ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612097.1">
        <property type="nucleotide sequence ID" value="XM_066759450.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991846"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0243730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="461" mass="50664" checksum="7DB476024B8C6968" modified="2025-10-08" version="1">MNGLLTIPLFNAAVGHASGTRLGLITAGYPLGSLLAFQLAAWASDRFGRKKAIMCGAVITIIASLCQGLTRGPWAFFGSRIILGIGTAFEIVAAPTIVAEITHPRTRAQSSALTQTCYYLGSIVAAWVTFGTLTLNSDWSWRIPILLQVVPPLFQLSLLWWCPESPRWLLRVGRRAEALDTLAKYHANGATEDPLVRFELNEIEAAIALEASVISQSSYKAFIQTKGNRQRLWILVSLGFVSQWVGMGVISYYFAAILRSIGIIDPTQQAGLNGGLQVWNWCLAISGALAVERLGRRPLWLISTGGLLCTFIVVTACSAVYANTESKTSGYIVVAFLFLFSGFFGIAYTPMGYSYPIEILPFGLRAKGHALSQTCVFMALFFNQFVNPIALDSIGWKYYIVFIVICAIQFVNIYFRFPEVKGRTLEEIAEVFDGVSIAPPETEIAIDEIWVHEDKLAAEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLW6</accession>
    <name>A0ABR3BLW6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar ATPase assembly integral membrane protein VMA21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VMA21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612152.1">
        <property type="nucleotide sequence ID" value="XM_066759505.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991902"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="9799" checksum="EA9981354B15BA15" modified="2025-10-08" version="1">MSNGVSTGRTAMAPQEGVQPAVLYKLVLFALLMAVVPIATYFGTLNRLWQGSTTWAAISAIAAANLILVGYVVVAFREDAASRTGPVSEKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMA3</accession>
    <name>A0ABR3BMA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612254.1">
        <property type="nucleotide sequence ID" value="XM_066759607.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992006"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="1">
        <location>
            <begin position="17"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="267" mass="30894" checksum="FF3777348D5F801F" modified="2025-10-08" version="1">MSDDRQMQRGKAGISWPAQELTSDPIAKFFQDRSKLSWHWNWTEHWKGPLVPATSDDLEIDAEFVPMIWSPQSLDDGCDLQEGWNLLLGFNEPDLDNEAVASHRSPQEAADAWIRLAQLRTDPDKQHLVSPAVASNAEWLKEFLSLIPEDTYPTYLAVHLYTTTFDDFVRKVEMYYNEFGLPIILSEFCMQSWDEGVPGPQDQQQVHDYMGQTTKWLDETDYVIKYCWFGAVRDRANLHGVHPFNRLMDENGKITPLGFQYMYGGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMG4</accession>
    <name>A0ABR3BMG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612352.1">
        <property type="nucleotide sequence ID" value="XM_066759705.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992104"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="92" mass="10645" checksum="F402E980E6E14F73" modified="2025-10-08" version="1">MTVCSAPGGAAEADDWELSGRKRVPKGAFPIFYYHTHALSISFPTFASSQRIFHESLDAYYPFYVYLYFRAHRLRLGRRAHLVIRQCDVRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMQ0</accession>
    <name>A0ABR3BMQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612417.1">
        <property type="nucleotide sequence ID" value="XM_066759770.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992169"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0244050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="125" mass="13329" checksum="92C658E6DCCE2EC6" modified="2025-10-08" version="1">MSLGLPVGAVMNCADNSGAKNLYVISVIGFGARLNRLPAAAAGDMVMASVKKGKPELRKKVMPAIICRQRKPWRRRDGIFLYFEDNAGVIVNAKGEMKGSAINGPVAKECADLWPRIASNAGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMR4</accession>
    <name>A0ABR3BMR4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612115.1">
        <property type="nucleotide sequence ID" value="XM_066759468.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991864"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="117"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0243748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="581" mass="65255" checksum="2F9A3A2A087C7863" modified="2025-10-08" version="1">MDSSSPPIASSSRVTLDNHSNDRQPLLSPSHSNHQHPVPHYRSISPASNPNPNPIPTRNMVSTMLGFTPKRVPEGSVKDVAVIDPTASAYVDPQTGALIEEKSKAERWFVARLDAVLLVFVCISQVIKYLDQQNISAAYVSGMKEELNLYGNQYNYFTTYFNVGYAIFLIPSQIIITRVRPSLWLPALEACWGILTIATYKVTNYKQVYAIRAFTGAFEASCYPGAIMLLMSWYTPRELALRIGFYHSCQSIGSMLAGALQAAIYNSMDGRNGLSGWRWMFIIDGIVTLVVSFAGLVLIPDFPSKPNPWSFYLRPPHIALARSRAAKFRRADNKKFTFASVKKAVMGPLFYCFVILYVASVLGQGGYNYFNLWLKSLTNPDGTRRWSVAQINAIPIGGSAIAVAMIWVWGFISDYFQTRWIPIVIQACIGLIPGIIMSIWNVSDNAKYFSYFACFLSLATAPPIFAWLSDLNPFDAEQRAFTLGFAIAFYYACGAWSGPLIWPASEAPHYHHGWQVTIAMWCLVIIMACSLRVVELKFIRPQNVRKAAEDEHEERIRQEEEDEEDKKHTEVERVISVVSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNF1</accession>
    <name>A0ABR3BNF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104736</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612686.1">
        <property type="nucleotide sequence ID" value="XM_066759199.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991592"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="62"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0245602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="545" mass="58177" checksum="FFDACD07C09A9C17" modified="2025-10-08" version="1">MVPLIRRPLQLRAYASAALASTSSNSKLSPLALKAAEDVSSKWRGTTANGGKTKLYIGGEFLDSKTDTWLEVRDPSSQTLINTVPETTPDEFTAAVDAASQAFKTWSKTGIMRRQRAMFELQHLIRQHAPEIANSIVLEQGKTYVDALGDVNRGLQVVESATAITSTLLGDKLEVSNDMDTYVRRLPLGVAATISPFNFPAMIVLWSAALATVTGNTLIVKPSERDPGATMIIAELCERAGLPPGVINVVHGTVPTVNRICDDPTIKAISFVGSDKAGTHIYNRAIVQGKRVQANLGAKNHAIIMPDANKNLALNSVAGAAFGAAGQRCMALSVAIFVGTAREMIPELIERAKGLKVTGGFEKDADLGPVISPQAKKRIEDFIGSVEEEGGKILLDGRGYKVSEYPDGNFVGPTIVEAVTTMKVYKNEVFGPVLTIVEADTLDDAIAIINANKYGNGASIFTNSGSTARKFEMEAEPGQIGINVAVPVPLPMFGWSGNKGSAKGDIPFYGKSGLDFYTYKKTTTSLWPAADAVGNRASVHMPQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNH1</accession>
    <name>A0ABR3BNH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104568</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612526.1">
        <property type="nucleotide sequence ID" value="XM_066759039.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991424"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0245442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42378" checksum="9A5D6E01F4A6EA88" modified="2025-10-08" version="1">MEKYSNWRDPATGIQPFLPPVSPRSGSSLIVALLAPLCIVHSLVRGILLGVLGTIHVLLVDWLCLLFVPIPPLYRVVNGGLTALSCRLALALMGYWWISTEMVSPRRGKAGVSQISKRSPRRGDLILANWTSYVEVLYLAFRHNPTFLLPVYSNDIFQELPKTGRHTGTGSAAINGPTALVQPPLLGYLPYTLTSLLARTGLPPAQYDVPPKGMYKTLREARRKEKRPVVLFPEGTTGNGRAILKFGEGVLAEGDVGGDDEGIVWVKFFRHSAPTAFSPSATCPLPTPLKHLFFSQLYTPTLYSRRSLHIRTLHPAASPSSPSFLPGEILNNQPGGLDAAGKDHKNVWREACAVVLAETGKVRRVKGMGWAEKKAFLEYWARGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNM7</accession>
    <name>A0ABR3BNM7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104806</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612756.1">
        <property type="nucleotide sequence ID" value="XM_066759269.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991662"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF85">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0245672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="294" mass="33469" checksum="40E2A0D76C358766" modified="2025-10-08" version="1">MSYNHMLPKKVSLKPKKHHGFQVFLWLLGLLLPPLAVAVRFGIGVDFFINVFLCICGYIPCHFHNFYIQNIRNNTNRARTPKWALKYGLVDNSSRERRARKNQWSKRFDERNNHSTLAEQELEEGEEGPNYDPSVENPEEVERRRNEGLWTADDEEYYNADQAPNQRKWHYPANFEGAVGDGRSYKRNASSGGDRWQRAARRSSGASNTYPPAAATDDDVPEWGKDYGSKRRSSKKLNKKQDHIHDWARNPEYGNGDESAARVGGSGRPSEGSTGNGRANGGATNGDPNWEHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNR6</accession>
    <name>A0ABR3BNR6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105509</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611910.1">
        <property type="nucleotide sequence ID" value="XM_066759964.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992364"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="43"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="557"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="798"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="561"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="621"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="852"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0243543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="869" mass="94367" checksum="953A1E3AF50303B8" modified="2025-10-08" version="1">MPSLWTRVKGWEAIKEPMLHQAVGRNMIALAPQTTPLESDRWMVIVNIVILCLTVLGAGMTLSSMAINELVLSRPGTTRTRIVQALVLSDLLLGIIGLISSSLTLTGDGHLMAHATTSCSGLGFMLTAILWSEHLWTLLLAFATYMILINPLHSMTLWLEKKWFYFYIIVWVIAVMMGLIGYKVYGYYPAGGICFYGNNTGLYAELIQFIPRAIVCLTITILYSRLIVFLRRPDKIRAKTGSTTGYSYETASDAGQLSILSPSTNPFRRNRTSTGNTPHGNQNTARAPASGETSESSQPVELIKEKDARPISASAGKPWYLPTSPTSSPANVTNLPPWERIELPAFQIDGEKFGGPATAVGGPSSLWNGWKGLGGRRRPSTGSSMVSPQIQEASKFGSISSGIDDGTVSPRGVDRELRASSQTLTAPQMETIVSGESRATPRDHLSSISPLPQNVTDDVSSSRHGKASSSATMIDPSSCAHRLSHGSFTNLPPSDITWAIENRRPSVATVLEPIERTKESKKLSMPSKALDNDAFIAPVEQSVAPQPMRPLSPVISQSIASQPHSPSQPHSPSQPHSPSQPHSPSQPHSPSQPHSPSQPHSPSQPHSPSQPHSPSQPHTGLFSNPKSLHSRQNTLSGPDVGTSSAPAVLEADELDEEMEMDLIKMLAAAPSNVDDRFAPPAGEHYELVPESISSYLNRKTAMLMLWFPLGYIFLFSVSFVRIIYDLCGNPPHALRAISRWFILAQGLLDAVIYGVIELHTKRVVRKRVRRGTFSPHHSSTGSKVANSTARVVNGITSRMTHSRGNGSGSGFGIGSATARNRENMPGDSGRVSHQAEQTRSELYGVHVMSVKNELDTSPRNEEEPVLDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP38</accession>
    <name>A0ABR3BP38_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104973</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612920.1">
        <property type="nucleotide sequence ID" value="XM_066759433.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991829"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="194"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="241"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="524" mass="56674" checksum="18F37A1DF7C4271A" modified="2025-10-08" version="1">MLGENTSGNLPGDVSNPFITKPSSPKKSRGTGSTDSTLASLRQGMGQMNISSKGSSIPYTTDIRERKDSKDTRRELDRFVPARPASLSHNPHSSSTLPTLAIDSAGHTPDTSTDHSLSQDQSTLSLQASLGLNSNRRILSFRSAPPLASHATSHLDAQRNYLLQSSASANRGTGSHSSKDSKKRAPPYMPERVLDAPGFEDDYYLNLIDWSCANRVAIGLGDMGYVWDAETGSVSALGSGTEEDANKVTSVSWSNDGAYLAIGLDTGDIEIWDVEENKKMRTMKGHLARVPAMSWHGHVLTSGCRDGSIYHHDVRVAKHKVMELVGHNAEVCGLAWRSDGQFLASGGNDNVVNCWDGRIGASILNDEGTPRGVAKWTKRNHTAAVKAIAWSPWQSSLLATGGGTADKHIHFWSTSTGARTASLPTSTQVTSLTFSPHSREILGTHGYPDNTLTLWAYPTLEKIWEVPAHDSRIISSALSPDGTTVCTGAGDENLKFWKVWEVRQAKKERDDGESGRGKTAARIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPD7</accession>
    <name>A0ABR3BPD7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612715.1">
        <property type="nucleotide sequence ID" value="XM_066759228.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991621"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="11885" checksum="A5AEC18672469145" modified="2025-10-08" version="1">MSANEQIRQNEQAINSYSAKTGAGKQSDSTVDSGVNEQVTAQFPGSTVQVGGTKRGENPPIPDEEGGGINPGTGHQTKAQDFEGPGGPEEKQARTAYQRPGDQNVPNFLEQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPL3</accession>
    <name>A0ABR3BPL3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613087.1">
        <property type="nucleotide sequence ID" value="XM_066758639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991017"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="342" mass="38329" checksum="D84EA31A9EC2469F" modified="2025-10-08" version="1">MGSELRTGSEDCFDDDDFPAAPGGKKPISAALSSQTSISTHSSLFSLRISSLKHKSTLPDVTSFEKLLPSLEDVGVNSWTPDRSGWREDRAESWRIRCGRKKSGSTMRVERKGWAPEGSFEFEMECQVLATNKPAPVTRESSSTEDKPPSKNKRKLDKKAELPLVTPQIASPPLSQTPSRDGSVKTKKKSKKKKRSVLANQSNPHHVDNYPYEPWPNHFDLISPPSMRFLATRPQRATVPLPGAPQRRVTVRPSEEDYICCFCEYDLYYGSEKARKRAIRRRRRELKRKEAIKAKAKNVAEGKGVLKDDSEEDDDDDECDDDGHGQCGRALPQTKPLETDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPW9</accession>
    <name>A0ABR3BPW9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104279</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613205.1">
        <property type="nucleotide sequence ID" value="XM_066758757.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991135"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF189">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="812"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="340"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="495"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="661"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="841"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1162" mass="126583" checksum="AC4F9029EA5B1872" modified="2025-10-08" version="1">MQRTLPPAHHCPPSSTPRAPPADTTVTPLRQSSSLACRPSTSSLHRSHKRVKSARQSFGNRAKREASIPMLSQQLSTFSLCQDISPEMLAQETTLASPFKCASHTTSASLTTPYTSTFKHHLSVKHIPQKSKSAGPKFVTQNAKDRHIKDISPTRPASGDHLADWDASHPSSDEPDLEWLQSGEWLPPLQSKENNVQGCLQGSLQHCRDTDCSLSSMEFGGSDTSSVSLLSLSRSSLDHQTRPDIVQWDEIPTETDEEQEEHRGLGAQPRSSALHLPVKLHSSPSISPFIASDCHKSPNDSQADFPMNSPSIFNARSSQHARSDSRSTILPRLLLSKKSTATLREQKEKSNVLGHMEDDEMMSDVEDIPSPKSPSRSRSFWDRAKFKTSRNPFDGNGLGATFGLGIELGPHRIPPSEGHNENNRLSVSIASDSSEDADLSPSRSLLSNRRSVSTFAHGPPRENVPEVASKREAPIRPTMPRRMATVGSIFRRMPRTSTPVIPTLNSLRGKGRPPMRRGTTDPTEKPKSNLQVADAALNTPQALPFADIKPSPSVFASAGLVQKKSRFSGVEIPKFGSEPLADVKRKQSAWQYGTQPGDGSVQPPSPISPIQSMSAPSIPLKGAGFAAAVSSNAHFAQQAQKTRGLRKKRSSMFKTGSSISSMDMIRGSSRGSMSGVSLSPVTPTKHDGIVKGCGLTTPSPIRAPVVYPFASSNPIDLDLFSTPPSNRLNRPGTLDAPVAERYRSMLAGSPNATVEAQRRPVIRASNPMLAASFKSAAQITTPARGHVSQDLSMFTGRPKLGGEGITRLETDFALVENLGSGAFSQVWKAREKKTGKVFAVKAGKPYTGVKNRLRQLEEIAILHELSLDPHPNVVQYVDSWESHSRLYILTTLVDCGDLSSFLSLLSDHGGIREARVWKSLVELAEGIDHIHKHHFLHLDIKPSNILIDRAGGLVVADLGMAVICGDGPNGHMLGGMSPALPERDERGGFVWDQVETPMDDGKKSLTMVPSPIMDREVEGDREYLCPEALSESEMIGKGADVYSLGILLLEAALNVVLPSNGDAWVQLRNDDFSDLNGIYIPRSCSASSPSRNPPLDDPNMPVLSDDLLTVIKGLMRSNPDRRWTLADIWRHPVVKRVRASERGKALVEESDQWLKKVLGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQD1</accession>
    <name>A0ABR3BQD1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613352.1">
        <property type="nucleotide sequence ID" value="XM_066758904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991283"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="66"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0247391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="108" mass="12724" checksum="FD8654EA0357B865" modified="2025-10-08" version="1">MLFCPYCANSLTIGDREDSTDKCWVCPTCPYQFIIERQISMRTHLKRKEVDDVLGGKEAWANVDKTDTACPKCDHRRAYFRQMQIRSADEPMTTFYKCCECGHQWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQE5</accession>
    <name>A0ABR3BQE5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104448</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613373.1">
        <property type="nucleotide sequence ID" value="XM_066758925.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991304"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="942"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="12">
        <location>
            <begin position="1084"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="1084"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="1087"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="349"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="502"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="676"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="753"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1243"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="359"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="686"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="794"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1247"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0247412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1266" mass="138713" checksum="1991E26407186155" modified="2025-10-08" version="1">MGSSQSQPSPNDRSSGNNGRPASRRTSSNPLRSFRHLSTMGRHAADTFSSSQPVNDSGEERENNVEVEMERTGSGNGGKRMRQASTVGDTRLSDIERKKPRMGERQESEASSSRAWPSHEDEPMPSAPTSRTSWSTQPYPQPASTPGQSTTLSPALSSDDSLSEERLQTLATIRDTLGPEWPLADSPAAPVVESLLRRHSSQNFAGPSSPAFGTGVGGLTPGNHTVAEARINLQRAMTQARNLADRITSMSARLNSGLLAASSRGLHDPQVSQPESQPQSQHELPSSTGAAHEVSSLAMEDLAARLREAREELAETERQLNETRERFESTTERTRVPTGAVLIVQGLAQTHTFPDMEEAQNRGENGRERAQHNEEDVGRHIALERDSESRRGSARPRRASESRVGDRVEASNEDGEGVTLQQQANMISGLLTVAAAATATTLLAPGGSRPSLASAVQPQRPSPSSTLESMLSRLRPNRPRQQTEQTVEASLGNYLRNVLRDNRVQGFTNPNTPLHTTETSSTAASSPADPPQPSQDPAADAAEEAISSEFQTFLEGLQGELVDAVRAFAGPLPEADEEVSAGDGEDVVQSMAGASLDPSSSRADNASPSARAMATQFTTAGNSISTSNSIPTFHSQLGQNLPGVRREIPSVTGGRDGVPRRLNFFRVHTFPAISPITGRQVEGRQDNGNGIQTEDGTASNTSPREAAEQQTPAIGNSVPQAQLHTRTQTPDDEPLIPCIFIGVRSIRHDPAMTTDDLVSHPQFPFVNGEVPPRPPTPEGEGAEENAAGDDAQEREDTLRDHDLNHEEDQHPTTSPRQERATSSPPERDRRSLRERLLSHLRRATSPASPPTSPLGPLNTYLVYVIGGNYPRSHPVLRMPSLIHGGAMTDEELQFVGDLLGSANNQTIEKEKLDNSGLQVIKGKEMENKGKAAEVIDSCVERCLVCLSGYESEEDCRILGCRHAFHKDCVDQWLTTGKNSCPACRTEAVDSKPSWTEESTATTAAVLSYKKGKLTEDEKLSIKKALEDYQKIHRMSSFDLVELVMTKTLQATYKKTVREFGKDIAASVPSRPILKVQPFVRRMLDPKAHKGRWTPEEEELLLRAYAQHPREWTKIPSIVDRTEVDCRDRYLKELLNRYTRTAGKWIKEEEDKLEEVVDRVAKGLRAEQANGEERENSGEERAVLVEPSDVPWDIVSKEMGNTRNQELDTNLKESVTSDPHVASLTYPELIKVIYDKAVIQRGRKVRADRRDYPNKETVESGEDSPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQI8</accession>
    <name>A0ABR3BQI8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613421.1">
        <property type="nucleotide sequence ID" value="XM_066758019.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990381"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="104"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="189" mass="21050" checksum="DDFC92D02902AEDD" modified="2025-10-08" version="1">MDSSEGKSWAWGVKNGVLDGVKARGTYEEVYNDPHVTVVYIGTPHVLHHRNAKDALLAGKHVLLEKPACLEVEELDELIKIAKEKKLFFMEAVWTRFQPIAYAVEEVIKSGILGKPRRFSADFSMDWDLDACPDSSRMVNPALGGGSLLDICCLPPLPARDILYPSSSLSLPRSQRYHHLLHHSPPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQJ7</accession>
    <name>A0ABR3BQJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_104209</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 15">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctomer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP).</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATPase e subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613135.1">
        <property type="nucleotide sequence ID" value="XM_066758687.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991065"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12427">
        <property type="entry name" value="ATP SYNTHASE E CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12427:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT E, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11 15" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 15" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0247174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="90" mass="9935" checksum="266C6D23F7E57CC8" modified="2025-10-08" version="1">MATPTVNVVRWSALIAGITYGIFHQSTLQAKYDEDKAKHHAAHRAHLVEEAKKAYAVKKAAKSGGSSLITDPEDPKFDLEKVIESWTKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRA3</accession>
    <name>A0ABR3BRA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613682.1">
        <property type="nucleotide sequence ID" value="XM_066758280.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990655"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="14180" checksum="914D56E5717C0015" modified="2025-10-08" version="1">MVRSGLQHDVINLYRKGMRIAFSKPAQVRPAFVLHLRYNFRNPPLKQRDYVAIEHQLRKMSKTLEMLSEPSVQKISVSEEMEDWWAKEVSRVRSRDVKKEKENDQATWTWGYMIRDNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRB1</accession>
    <name>A0ABR3BRB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612795.1">
        <property type="nucleotide sequence ID" value="XM_066759308.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991702"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="6">
        <location>
            <begin position="766"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="7">
        <location>
            <begin position="1700"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2134"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2217"/>
            <end position="2260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0245711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2313" mass="259170" checksum="58C2D39894211C00" modified="2025-10-08" version="1">MSSQQPYMASSYHSLHDFVPRSPRSLATGTWQPLPYIHSGFAIYPFHPEASSLPAPTTVDGTSPKLAPLSSHQDLDALPWTGSKPELAEGGLCSQGKRNHYEIRLDIGDEFYAFEEYRCSIEEDGRGDLWYRGFVVQAVSITSLSPVILSETTSAQKASFPRPEPSVLIGIFPASVCHVRSGNENDTGELSVAYEKAIRAAQQRYRPVGEVSDYDHPALGTGGLSEMDAVKEEDEEDAELVSRSQNLDIERAVVEVGSSEGRPIDVLSRKGSKNSFSRPNRPKSLVLEQQKTVVEKDKDQPPLPRLTAGDSTSGGQQWPLVDEIACAIREWYSRLPSYLANREYRLFNTVTQHIDALFLGRRQLLSQMLSDDELVRVRRECVSRLVKCNVAQGLDVIVRSFEDGSMVVVDKKRAYSGTKWVGGISCYVYQVRLAYIDVIPLDNVFEEVFSSRKALSQPHALTSAKNDFSDLPAGSFYHLFLDVRAFVANPCAPGETAELYFSLYNKRHKRFISEEYCLILNHYGSPARDSEQRLGRLRTLFTDLKAEDLAPDTYLVCKIIRNGAMKTRSDNGMPPASLSASVARHRSSLYDISATELSDHNQREGESFMDLTDDSFSVTSGNGPESHRPPTIDTTNAAPVSMVGGGSAFGSKIRVKRPLGWAVMLLPPMSKPIGDWLDRDGGGVEQSVKIYVPREEKEFAKMFDDVIHNRVKHYMTFPKAQYIVLYLKSLRGPAPQLVREHPSLLLDIPLTSRLSFPDVVFPGHSRDDLYIKLCSATFRSAPSPSSASTRMKKNVSISHNGDVQVAMEIRKVDGTVVEDAIMAGGSGEPGTSQWNSMVFYHSDKPVYDELVKIPLPVQLSEYHLFLTFRSMSKNKQTAGDEAEKPFAFAYLPISATNMFVTDDDHELVLYHMEKDFQLTPSLYFGAAHSAKDWAGDDVLPKTTLKGMSPSRDRVMISTRLCSSVHTQDQTLRSLFAWQSATESGNIIALCETLNMFGFVDEQEISRFVPRLLDSLFGILVCRLSERREQLDDLVFKGMVKVLTMANDRRFPNFKNVLNIYTSNQFYFPAASFHLLRSMKSVMASPHTKGYRLFLKVWHLFFQFIIRSREQDRERSVGADATSAHIEAEFQSQIKHILKEINNLMESADQSLIGTQTLVVQHYASILPDLAHIFQPLEIAEMVIAFVDTLSFGTGSIVTYKLLLLLQVVKNILETSESRHLLVPAIVRWLKPHLGRFDEHSGGMEAAQAANDARRMKWLECNRLAVTGLAWMTEKLQQCYVSPKVQADDDVKRREEGNIQYCLTLLPGLYFSYAELSGPRTLDAFQRQRSSVTSTIWKDIPDIFPTSHPFALISQLPPPSLVERHHNANDSGIPASELFNCGLAECAVVILNLILATSVDGVIRWIRETLDIEGAESCRKLFMRSFDFAKSVISFEAFPSQWLTIRSMCFSGLLKLLECIATIMEEDIFVPLPPKSDGTSILPTKLEGFDDNLWRKYFEFLCDFCGSQELALEDQTPQRRRAEWIVSGDLREGGARLLLRLWNAVGWPLDIPGGHALRMGGYQTRFTGLGSKVLELCQSSHDALCETAVEILFSLIYAEYLLDKEGTSIETEVFVALDKLFTAEATLSSSDPTLKSYFVAELRNIFESFPEIHPSFTAKVSNFLSQTEYFIDLLLVLRDIPAGSLWQDERATAIYQLMNFVNAIGREGLYVRYVHELVKNSKSVKDWLGAGLGLKLHADIYGWKVGDEHWVDAGRWGDLELPAHSEFARKQAIYYHVLGYLAQAEAHEFSVNLCQELITQHQRLTYDINMITELLAHQAKLWATIGEARRPQQEYFRVAYFGEIFSLDKNKDYVVRAQVGQTYTDLCNMLQSKYPQAAIHSSKIPPPESIKRGVNPVIWVTPVTPEPDLTKPVFGENVSNNFQSYWKWNGIKEFSSVRQYLKDELERETTWAWTEKTLLTTKDELPGVLARSEIISIRYAQIPPIAMAIMEIKTAIKSLQKSSSGKNGQLPESKALGTAINNAMDSLVSESIKEYRKLFIEGPYLDSHPEDYEGVQQLKSTIIQYVRAIQDSLEVHKRVCRDVAFHEILKNQLYKSFPEEGGSPSSSASSDDEFPALSSFALDAFDHAKYRSSTKSQPSISMSFHPSTTDRPFSDYRASNVTSMMGSEGYNLPPLKIGRSASSGDQPLTVHNGSTYTHTSHESTSTTRNIPSTSVQADIITPTSPPLRTPSKAGSAGKKDHRKSLTGPWRTSELGHGRNDSVSSLSIRAKNMMGIASRLSSNVLAEGGVDKEPPPALVKERGLKRFGSSMRKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRC1</accession>
    <name>A0ABR3BRC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613164.1">
        <property type="nucleotide sequence ID" value="XM_066758716.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991094"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047404957" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="45215" checksum="C0D24D0E7924CAED" modified="2025-10-08" version="1">MKLSTTLPLVLFPALAFAHADGIHPAHRRHSARSGSGGYGKRAPALLDDLTGLLIGDSGSTSHAASTSTTSSAGASSSSVHSSVASTSAAATTTSQNEETSTSVASSLPSTSSTSSTSTSTTTTAASSSTAGPSVNESSTVSSSGSTSTTPSPSSTEQSLSPVASTSPSTTAESTALSSASASVHYTTNAAGQTQLVTVVLTQSVVDATAHAATASATSTSAAKESKFPTGGIIGICVGVGAAILALIALAVWRMKRRGRDEDEAIRWPELNRHGDSDAHHALPARETGQHGFETNPLQRSLSSSSELQYADYPIASHPDYGLPQHSPVPMALNGSSFGASSSLEDDYALSEKYPPASPHAPSHDDHDNYTSLPPPVQPQASVGLGMGGAMFGHTTTPEKEEDPYGGVQMTQLSHGVTYQDMTSPEYSHQPMPNPHDYRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRK2</accession>
    <name>A0ABR3BRK2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTPase activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613754.1">
        <property type="nucleotide sequence ID" value="XM_066758352.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990727"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07652">
        <property type="entry name" value="F-BAR_Rgd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04398">
        <property type="entry name" value="RhoGAP_fRGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF134">
        <property type="entry name" value="RHO-TYPE GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="124"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="591"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="794" mass="87108" checksum="E6DA9D00A1BF0134" modified="2025-10-08" version="1">MEQYKDDYVDVKRPEDDSYSFRSRQYSLDVPQPSQPQKPPSPVKPPLTHNSSSTSTNAATSSQYDHYSAESTSALSAQSIQSTQSAQPSAQTANERRMSVGLGAPGGLAAMMGAGQRTEEPVPLGFDEGILRALCEMDGALPLLADRIKQSITSCKQVATFFRSRAEIEEKYARSLVELTRTTGDTYSRADCKAGTFVTAYNSSLKVQDQISQNRLRFAQRLYEMSEELHTLAREGEKARKTHKETGVRYQLIIQDAESVVEKSKSRLDSIIDDLDRILAAKEGEALKDVRSGGTYNTIGGPAYGGAPSSNTSLNSGSGKSKLGKAMKTGGLLFKGKGAGSLQRQEDDSRAKMDQANETFTKAVAESKQLRKEYFNYQLPKILRILKEAADELDLGTQYHLTRYAFLYETMTVSDGMVLNPLGSPEEGLGLKAVFENIDNRSDFKSYMQNYAVAKGTPRGPRREGPYDQGYQKALPPHVQRSNDALAASATSPQPQPSPQPLQSFNYTASPQSSTQAQLHASPQPPSQNFHYPNASVASTGTANTNNTLPSIPQQSSAGVGVTDQSSLTSFSNEGWVPPGIPASTGATFGVDLSEQLLRDGTVVPKIVEKCTQAIEMYGLESVGVYRLSGTTSRVQALKAALDKDVDAVDILSEEWSADINVVCGALKLWFRELPEPLLTYGLYNAFIEAARYDNDRLRHIRLHEQVNELPDPNYATLKFFMGHLDRIRKKESINQMSVSNLSIVFGPTLLGAPPEEGGLNLEHMSFQCKAIETILDKYHEIFVEEEEDGEQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRM3</accession>
    <name>A0ABR3BRM3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103907</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613790.1">
        <property type="nucleotide sequence ID" value="XM_066758388.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990763"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0247829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="281" mass="31082" checksum="3AC32DD0C4A4DA67" modified="2025-10-08" version="1">MKWNIGSSSASTQVPVDHTAATSIPSDHPHIPISSSSRPPPQCPMHQADVPPAPSTANAPAKCPIQHDALDPTTHMPVNLSLSRQPDQKLDLPTERTASTIPRPSAAPGGEAYGTGNTWDYPSPQQFYNALVRKGWETPEDSVEVMVAIHNFLNERAWDEVMKWEKRLPGGDQSQLARFQGRPGELSPKARFHLWAGKLFPSKFNTEPPFDRHDWVVTRPSPSAPQGTVTARYVIDYYSAPPDEDGNPVFSLDVRPALDSLEAIKQRISVGVEEWLREDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRN4</accession>
    <name>A0ABR3BRN4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613807.1">
        <property type="nucleotide sequence ID" value="XM_066758405.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990780"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="171" mass="18827" checksum="86DDC40B3C5AC284" modified="2025-10-08" version="1">MSNDSENAPSPASKVFADRLAKYAYVATSSSSSPRMSPLRRSTRSQTSISSATRSPPPSSSQDRIYDRGSPLKKVASSSSSSILLSTTKKRSAKSISKEDEEFQVIDVDEEMDDEDYKEGGLNSAKRGRKSRMKKAVKKPRGYAAPEMYEHLRPLNDLLVKGQVLVFCGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRU1</accession>
    <name>A0ABR3BRU1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613864.1">
        <property type="nucleotide sequence ID" value="XM_066758462.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990837"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="386" mass="42013" checksum="202137E475FD4FCA" modified="2025-10-08" version="1">MILVSKVPKHISETCIFTNIILFPPIAYPMPPVQQPLPPAASTLSAPASSLAAAASAANVTFATSLREEVSFAGSLSQSPSSALSAQDKAKTKAPGNKSKPADSSQEGKPRFQGTRGSNNRKVYSTLIAEKRPQFCEEHGIPYFTAVGVSCKGLSPSPIVGRIADLQKLFQDANALQKPNQLTGEGVTEEDIAKGNDTRDKKLRSVITNKRAEELGKSHLSMTTNFLMSEDIFIADKGGERVGDGEEAKSILPILGATGKGSAVNTKKLAKGLKGKGKSRGSETFQSQYPPPYSGQDNIIQMMLEVIAVDYKGRMEFAAFQAEAVTKVRAEGREAREARWKIEDERNSRVRAMEIEILRDEQPRQREVEDEASALLAPKERRRPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRZ3</accession>
    <name>A0ABR3BRZ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhodopsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613913.1">
        <property type="nucleotide sequence ID" value="XM_066757529.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989883"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="13801" checksum="C7A99076DBB45904" modified="2025-10-08" version="1">MSAKDYYGNQQQPYGQQYGGYPQQGGYGGPPQQGGYYPPPPQQSYQQPGRTSPFPNLPAFSYLLSSTTLNPSLSPYTSNNHLRNLVAVAQAVALVLSVLSVVAAPKNSVAICCSKLLISSLPSAFALTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSC4</accession>
    <name>A0ABR3BSC4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614037.1">
        <property type="nucleotide sequence ID" value="XM_066757653.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990009"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="597" mass="67840" checksum="DCD089727B166CCC" modified="2025-10-08" version="1">MNSPTPNTPLTLRAILLTSSSLPPEPRLPSIRFRITPHFLVPDCIVSPLINSYNIGHCVETIVPMGGKVEVGLTVDEESLSDCGIECENPSSRVMRGVTESFRLNAQSLSLSTMAPIAQSRLDRSTFLLTPLASTPSNNLLLTHMIPTGHPICYLKRFDIHCSWTMTRTGGALKRPVEDAEYEDGQAQEDIIDDLMILDDHGSAVPDQTGSNDEDDGQIKLLPEDRPVCNWLDHLIGNACQKLLLRHFLRRFPLIFDGRFTEALPKYILPSQLISSVSQFAWLSTAYDTPLHQKIGEIMKKVTWQQQEFLSLKLDQTVNLPARKDRKLEASQRRQKRLKQAKQDRDQLDRIPKEKGSPEDEDEAIIGINRRKERYMEQLKASMDASDNRGMRRDERKISRIIGDAIGLICRSDFEMRRNRGGRLSAAGTKFQYPTDDAHQPLPISDAQLFLTSRANSNAASDTSRDESFIENALENNLSYEVLVDDQEEWSLMRPENTESFAEQQEDEDEDVDVVFIMDDGVDDDQEDDDLLPIESWPLEESPKPRVVPYHNQSKEAAVVLRIQHFEEDTIMVDGDDNMDFEILELEATFVDQKQSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSC6</accession>
    <name>A0ABR3BSC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_103158</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614042.1">
        <property type="nucleotide sequence ID" value="XM_066757658.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990014"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0249855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="584" mass="62060" checksum="4DAE83B73BB3CA38" modified="2025-10-08" version="1">MVLADLGTRLHGAWNQLSKASVIDDKVIDSVLKELCAALLESDVNVKLVASLRSKVKAKVKKSLEESEKAGGREANKKNVVQKAVFDELVTLVDPGTEPYKPVKGKTNVLMAVGIQGAGKTTTCTKLAVHYQRRGFRTCLVCADTFRAGAFDQLKQNATKAKIPFYGSYTETDPVAIASLGVEKFRKERFDVIIVDTSGRHKQESELFEEMVAIGAAVKPNMTLMVLDASIGQAAEGQSRAFKDSADFGAIIVTKLDGHAKGGGAISAVAATKTPIIFLGTGEHLNDLERFAPQPFISKLLGMGDMQGLVEHMQDMARANPDRQKDLAKKLEQGKFTIRDWREQLSNIMNMGSISKIASMIPGLPAGIMDGNEEEASAKLKRLIFITDAMRADELDSDGSIFVSYDKEGNPVGLNKRAKRVAKGSGTSLRELEDLLVQARMMAGMAKQAGGQNGWMSTMQKMQAAAGGKPLGPNGQPSPAQIEAMRKAMPPELVRKLRAAGPQGAQKMMQDMMGGMGGMPGMGGAGGPGGMDLGNMMRMLGGGGGGGGMPNMSQMQEMMKGMGMGGGGGMPDMSQLMKMMGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSD0</accession>
    <name>A0ABR3BSD0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103163</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614047.1">
        <property type="nucleotide sequence ID" value="XM_066757663.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990019"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="50"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0249860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="783" mass="86282" checksum="9A455E2C8260B6F1" modified="2025-10-08" version="1">MPPLVRRSVTSSIPTLLSITKLVHLVPRTAQQWSSIGASAPPIEPEDPPGSTKFWWKLGLSVVLVLAGGVFAGLTLALMGSDDLNLRVLSASSSNPKERKAANKVLRLLARGRHWVLVVLLLGNVIVNESLPIFLDDVLGGGLYAVIVSTTMIVIFGEIIPQAICVRYGLSIGGVCAPVVWALMILFAPVAWPIAKLLDHVLGKDEGHTYKKAELKSFLQFHREGEEPLRDDEIVILNSVLSLNDKHAKEIMTPIEDCLILPFNKILNHSTIDEILMSGFSRIPIHEPGQKDNFLGMLLVKKLISYNPDDEWPVSKFPLLPLPEAKPDINCFQALDYFQTGRAHLLLISDTPGQKGGALGIVSLEDLIEEIIGEEIVDETDRYQDNHSKKAVKRSGTAAVMRGIIERRRVLNAFSRAPSRSNSQTPAGLSVPDGRGANSTNGILVQVSEGSLIAESADLSNNGATATVDPSKRLVLSAAEPMSRIQEANTSPKVIYETVQNGNGENGVKKESKNDKADKRNAFNRQGKYESNIESEAYPEHESFEKACKALVDKYLTKEEEVGPGRTNKGWEWKEHKCVPHQGYLYRRIVRYVPSTLVGHPLSQTQSYESLDQTKEDEEDLEEAEDSALLPQQQDVGRSTRVKIEIEQYIVYSRTYRVPMYCFRAWDEAGAPLSISLLLKLNILRPPSSPQPLGFGDYGAALDTIMLPPESLPGEDTSPFPLVQSTEHPTTGELVFSVHPCRVRGAVEEVLKAEGLGKGARASLEWLEVWMAMTSRIADLTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSE6</accession>
    <name>A0ABR3BSE6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614060.1">
        <property type="nucleotide sequence ID" value="XM_066757676.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990032"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="350" mass="40125" checksum="1A59D00EF70674D2" modified="2025-10-08" version="1">MKALHSKTILSQHSTVPKARPVAHHIRKLYTTGLPKRLIRGKQEKAQEQIQIDDGLAICLFGFSTQAQKQQIKVSEQVLTQPSSKKQLNMYDLVQEEELRQQTVMAEVLPDAEMWKKWEKTEAPLRQGRGWYPRLDRHFLELLVISEIHCLSYPLDRNNGPSGYAERVHRHAIRVRRVACERIGAERLHAYCERVKEAFEAYMMGGWAKVQAHAEAQMRSQMEMDHFEDAEDQEIDEIRGRKMERGNGSMIREVTTVQKPSPENPSASTNPFAGYEDEEDLSHLLEIDMKEVQLDGLSEEVSEEDFDYSASIKATLEMNRNEGAGTTMDVGNEPTYWSLTSGEKHDPQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSI7</accession>
    <name>A0ABR3BSI7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614096.1">
        <property type="nucleotide sequence ID" value="XM_066757712.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990068"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0249909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="268" mass="28863" checksum="04D4550ECF7E3B8F" modified="2025-10-08" version="1">MESVNHIQLTIHPSQVRPILRALLLAIFFHRTLDAMEPETLELLESHISCAPNSIISREISNKIEEFALQYLEGGQDHGELAVVFLQKKSKKGWFAVTEELVPWEEHLITLNFSHSPKTPLNPLPGALLQIATFCLEQKAMVPPLTGTTESQSSNVSYQIMIAPPSPNDLFAPSSPPSYPTRLTSPPPASSPSTTPATSVARDLAVSHRPMLENPNSARRTSSPTSATLGYFEQAKDGLRAVGAKAGAGVGWGGRAMGAAFGRNAGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSS8</accession>
    <name>A0ABR3BSS8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Polycomb protein EED</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614202.1">
        <property type="nucleotide sequence ID" value="XM_066757818.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990174"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="244"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="65219" checksum="CEE37EF3FE051855" modified="2025-10-08" version="1">MPTVPESSQSTIDFGSEPTRPPASFAEQESKWYRRDAGNSKQRWISHPYAIHSIIHQGDSLTTDLDRYDDVKFWPFVGALKPWKRPDGLDQWKWDEFEDTVAFCGLDKAMIGKCEDNQPWRVILDMCFEDDTLYTLAWTYHPFTCHPLLAVAGANALIYIIDIITKRCIRTLKGHGDEILCLAFAPLNPHILASTSSDRTTRIWNILGSDAPAPPPGDLPNENYPMADADEGNVIVAVLAGEGKGGHRAYVVSCAFHPTKRAIATCGMDYTAKIWPLPPFPDPSPVPIPTPLGYRPTIVYFPLFSTSRLHYGFLDWIEWITDDILIIRGDKVMVTWQWLSYSRYFREDEYAPLSMEPASYSDYSDSGSFMVVSRVNTLTDMWFRHPHLHRGFHPTPADLARFPNSINMVTDPLLACPHQMDPREMTKHWYPEIRLYNLLLARDGRPPRPITELRPYKPEVYDMSVDFEEEGNIEGSKVRKKSSTPQASKRKYITFPEEKSETRSATGSAHNSLIVPWRLRPTTSPWPKKHEPWLGPQYRTGICNVTISPRGARWIVGVGEGMSIFIWRMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSV6</accession>
    <name>A0ABR3BSV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_103344</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614227.1">
        <property type="nucleotide sequence ID" value="XM_066757843.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990200"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="351"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="589"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="869" mass="96183" checksum="4FC2378FCB27FDE5" modified="2025-10-08" version="1">MLAEILLILSGHSSSFFIPYPSPPAVPFTCKTSPSLAEYLHPGEITSLNSLADLAFQYRKVKTWVNDIIDCGRKAILAESLRPSRKGKEREVFVDDKGGHIKLNQYLMTLATSIMEVLNGYELLIVETEARVLSFDPAVVQDQQGYVPLSSIVATFDRWRAPMTALSKIVDQLSSPNQRGDSWSPGRLIDLILFKSQTGNPFLQEIFSSLAKSLRVLFLTHLASFILYGIAPSKSQMTSPSIGRTVGVDPLSPQYRVYALNVDMLPTSVEENTRESILYVGRVAATLKREGRSLPKSLVDDLQRELTAVKSLEVGGGLKEAVEDARAEIGEWLWRHILTGPQVAESIEMFGNFFLLRKTDYCISVVRGISQLRLDKLLISNPHSSSSIIREQDLDLILRRASTGTSAELDSQLDFLHFKMEKGPLRAMLPTVPMKTPKQSGIESTVEHRNSIRELFSSSLIGTPLILTTTVTWPLDLFISPQALSAYSDIQAYLTALRHTHLSVLSCWTTLSAAQRQRRKWTGVTEGGTDEEVGARRRLGRVAWGTIRLMLFFIDQLQSHFMTDIIDVQHKRLLGQLGLDTALSAPVPGGSVRGSSLRGSISVRQTPTATKNRTALPSPATENGERNRAASPFSDAYSVPCDGQTLRSNRAPPTPTKVQKVHLDFLTLRQLHALHLSFIQEGLLIADVHLATIIRDILDTCRRYTGLVERWGGDVLPELLMEGIDGEEVGKMVKERAQAVQEINDTLHELLTDFFGALLDTQNPGAADPDKSIADGGGSLSRTMRAAQISRMMSRQASFTAAAMNAKNGAKNKTQVDKEERELEADTVMARHIEQLLLRLDFNGVLTAWRLKEVNGDYSGGNVLIERGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSY3</accession>
    <name>A0ABR3BSY3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103866</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613749.1">
        <property type="nucleotide sequence ID" value="XM_066758347.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990722"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF697">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="46"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="451" mass="48872" checksum="0E83916D0E35AFC4" modified="2025-10-08" version="1">MSFHDPEKEAVTSDSIKPVASDSEVDEQNEVFRMTSSGEQYRTVSWQSFALMFKILFSVGVLSIPSVFSYVGALPGALLLIGWGAFNAYSALLLGAFRLRHPGIHGMQDMAYIVGGVWYRELVGLLFIIGGYIGAATALNTLSDHGACTVWFSFVAFVLSTAIAMFPKLAQVGVAAWAGVISLFISIFILVVAVAVNDRPALAPATGDFDLGYHLIGSPNFTEGMTAALTIFISSGGISAFVPIIAEMKNPKEYKKPIAVSMGFLNACYLAFALVIYRYCGTWISSPALGSAGPLIKKLTYGIALPGLIMSSTVNQHLAAKYIFVRLLRDTKHLQSKTMIHWITWFGVSLLCGVAAFIIGEAVPFFGTLISLLAAIAYAPMAIVIPMHLWLYDFADYRKQDIIKKLQWLFHLVMLVIGLFMTFGGAYTSIKSIADQYAAGTVSSAFSCADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT85</accession>
    <name>A0ABR3BT85_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_103480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614359.1">
        <property type="nucleotide sequence ID" value="XM_066757975.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990336"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="366" mass="42123" checksum="003245A716BF59AE" modified="2025-10-08" version="1">MTIDQSQISFNVPSTYKLEEIVGEGAYGLVVAGTHLPSGTRVAIKRITPFDHTMFCQRTLREIKLLRHFHHENIISILDLIQPESYEMFNEVYLVQELMETDLHRVIRSQELSDDHCQYFVYQTLRGLKALHSADVLHRDLKPSNLLLNANCDLKICDFGLARSSAKPPPGTSDGGQGFMTEYVATRWYRAPEVMLSFQEYTKAIDLWSVGCILAEMINGKPLFPGRDYHHQLSLILQVLGTPTMDDFNEITSQRSKDYLRALEFTRRQDFSAICPKAMPAAVNLLKRTLTFSPSKRITVEEALTHPYVEAYHDPQDEPNAEPLKPGFFDFEFHQEKLSRDQWKRMIYDEVQDPVPTILSQWTANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTN1</accession>
    <name>A0ABR3BTN1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102482</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614496.1">
        <property type="nucleotide sequence ID" value="XM_066757027.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989339"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="169"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="428" mass="48647" checksum="93D939F6E5A2FDAC" modified="2025-10-08" version="1">MISAFFIFNQKGEVLISRLFRSDVKRSLSDVFRIQVISNPDVRSPIITLGSTSFFHVRVNNIYIVCVTKCNASAALIFEFIYRFITVARSYFGKLDEESVKNNFVLIYELLDEIIDFGFPQNSEIDTLKMYITTESIKSEMAVREDSSKITIQATGATSWRRSDVKYRKNEAFVDVIETVNMLMSKEGSILRADVDGQILMRAYLSGTPECKFGLNDKLVLQKRVGEQTAKSDSAVELDDCQFHQCVRLGKFDSDRSISFIPPDGEFELMRYRSTTNINLPFRLQTHVVEVSKSRVEYTIHLRASFDSKLNANNVVLRIPTPLNTTGVRSKVGIGKAKYVPGENVIVWKIPRIQGAQECTLTAEADLAATTHRQAWSRPPIQVDFSVVMFTASGLLVRFLKVFEKSGYQSVKWVRYLTKANGSYQIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUS2</accession>
    <name>A0ABR3BUS2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614888.1">
        <property type="nucleotide sequence ID" value="XM_066757419.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989740"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="359" mass="38898" checksum="D24DD3155424B86A" modified="2025-10-08" version="1">MVAPTYDALKLPPHIKTILVTGAGGFVGQQLVKLLLELHPTVKLITTDIVQPPNHGVADTNRLRSVKADLGKQEEIDGLIKGETIGGVFALHGIMSGGAEANFALGYAVNVDSNLNLLKSMYNYSLSLPTDAPRPVYVFVSSLAVYGGPKCKPTDYVVPKDTPIIPGSSYGVQKTIIELYAYDYGRKGYLDTRSVRLPTVAIRPGAPSSAASSFISGLIREPLQGMEAICPIAESIDDPALDNMPFWCSRTKTVVRNIAYAMCMPESNFKEGEGRSINIPGIKISPRQIIDALVEHGGKDKFNLIKFQKDQAVINICKTWAGEYDNADFLAMGFEADDPKTGFALAVQDFKDELAANQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUS4</accession>
    <name>A0ABR3BUS4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613743.1">
        <property type="nucleotide sequence ID" value="XM_066758341.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990716"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="129" mass="13825" checksum="5D8ADA109C46D4DE" modified="2025-10-08" version="1">MPAEYVLTNGAPPPLPGIYTQAVRAGNYVYTSGSVGMTKEGNMVEGTVQDRTRQVIQNLEAVLKGANMTLSNVVKANIYLSNLSKDFTAVNEVWKDTMPEPKPARTCIGVAELPAGGTDVEIEFVAYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUV3</accession>
    <name>A0ABR3BUV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613773.1">
        <property type="nucleotide sequence ID" value="XM_066758371.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990746"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="6">
        <location>
            <begin position="41"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="130" mass="14857" checksum="FBEABE66E164158E" modified="2025-10-08" version="1">MMFLPSFRASSSRLAQPRLFSTASRMLQKAPLAASTETATPEELLTKIGRNADKKLTPFAESWDKLNEVWFKTKKMNDLGLATKEKRYILWAFSRYSQGSAPSTFIRPPKPPKKFRGWGPKIQHGVRVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUZ5</accession>
    <name>A0ABR3BUZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta14-sterol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_102862</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614866.1">
        <property type="nucleotide sequence ID" value="XM_066757397.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989718"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0250679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="52069" checksum="14C1562DF48F28DD" modified="2025-10-08" version="1">MSDQEESTTTVITATTHLDLPAHPHIKTYQELNPRSKPTEFFGPWGTGAITLFTPLFTYFFFFACNDAVGCTPTSVQGWKDALALVGNYPSSAGKLWEWKAAGVYLAWYAFCMICEVVLPGQRVQGNLLRDGRRKVYRMNGLYTLLLALGLLTGVLVQPRGIQAFTWLHDHFVPLISASLAMATFQAVWVYVWSFFSGELLALGGNSGNVIYDFFIGRPLNPTIPGFSSFDLKTFNEVRPGMILWLLLNISCACEQYVRIGKLTDSMWIVLIFEGWYVLDCLVQEHTILNQMDITTDGFGFMLAFGDLTWVPFTYGLQARFLASTSVELGPVATALIVGVEVAGMYIFRVANNEKANFRAGKNPKNLEYMQTERGTKLLTSGWWGRSQHPNYFGDWLIALGWCLPTGFNTPLTYFYLVYFVVLLLHRQKRDEEACKLKYGKDWDRYCEKVPYKIIPYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV02</accession>
    <name>A0ABR3BV02_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAM50A/XAP5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614115.1">
        <property type="nucleotide sequence ID" value="XM_066757731.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990087"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="185"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="323" mass="37570" checksum="904A3B8E95D2AFC6" modified="2025-10-08" version="1">MSGPPEESRRHLILAKQREKEAAEHQRQKDALLKESQRDHTADRFVGVSENLDERLIKTTVGLVTLSDFKKTKGDLEEQQRKLAAQVQLEKTASAAKIKKARKKERTSKLSFADEEDGNEDEISTGGAKRPRENEGDAHVRKKFTKNPEVDTSFLPDRNRELQEAEERERLRKEWLAQQEKIKAESIEITYSYWDGSGHRKTVECKKGDDIATFLSKCRQQFPELRGTSVENLMYIKEDLIIPHHYTFYDFIINKARGKSGPLFNFDVHDDVRLIQDATVEKDESHAGKVVERSWYNRFKHIFPASRWEVYDPDKNYGSYRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVA1</accession>
    <name>A0ABR3BVA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615031.1">
        <property type="nucleotide sequence ID" value="XM_066756254.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988558"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="87" mass="9593" checksum="01B8ED459FEB9A70" modified="2025-10-08" version="1">MSRACFDPTESSKMWERMSASEGGKGLSVDFLSTHPANAKRIKQLENWMPEALQIRAASPCGAMSDNFNGFLDAVNPTGRTYSASFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVC4</accession>
    <name>A0ABR3BVC4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101731</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615062.1">
        <property type="nucleotide sequence ID" value="XM_066756285.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988589"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="512" mass="58322" checksum="8B43941EE6B852DD" modified="2025-10-08" version="1">MDSIIETQRQTHEGIERYEQALAEVLMQNPTATKNVVRRDRKAAEILGRIGTLRKELVEQYEDIPGLRPRELALLSAPAPGEDDLAEFYTRFNKIKDFHSRNAGINARQFINELDELVKGDGVQVIQVEGEEEPTVVDPLDSVFSGEEAYGKHLDLYLSHSQYLNLKGSTRLSYVAYLDMLKHGKVERTLDVKEKSNAAYLEYVQTLYTYLLSFFERALPLVNVQEKIKEEEQRFEKAWEANQVDGWENSGAKKQANNGEGIWCQYCQKSYSKQTVYDAHLNSKGHKKKAAEGQSAVPNTSSPAPTTANNSNRSKLMVPARLTYLITSLLTFPPIPQLLSDSRNEVERKMALTAREREQEIEEQEEGPTEAVELGGHESDEESDDGKIYNPLKLPLGWDGKPIPYWLYKLHGLGVEFTCEICSNATYNGRKAFEKHFMESKHAFGLRALGLPPSKHFMYITKINDALALAEKLKREGRQEITAMDKAEEFEDEEGNVYDKRTYEQLQRQGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVF3</accession>
    <name>A0ABR3BVF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615092.1">
        <property type="nucleotide sequence ID" value="XM_066756315.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988620"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="6">
        <location>
            <begin position="1435"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="748"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="956"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1528"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1837"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="818"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="882"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="988"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1012"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1852"/>
            <end position="1862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1878" mass="208360" checksum="0567E4C5BE377A00" modified="2025-10-08" version="1">MPPPTPESASRPPKARTRSSTIVGTGPLPLGSVQAGPPAVDIAASSFRVTTNPQASAATEALSSLAGSIIKPKLRETSADHMRATSWPSPPPPAITSMPSAPAVPTKGSMEGGVLDLSLLNKDKDSVALLLYTYKPLLHNTGASANPAHPSPLPSSAASPNAPSSQVTINYAALPWSVQPGDYLEIRQLNRTQLKVPTASTCIQGMEGEKPKKVKRPPALEDVKTGKGREGYVFRLGEDSPTANIHQIQVPDSVATAFGFQNRLEVEVRKVHDKESAHADYVEFYFSQYLGRADMWRLGMSLEGTTLHVGEKVSLAGGAVRAEVNFIIREEKSKDGIGKPKRYSSGIVTAKTKTIFRSKSAQAYLFIQLCEETWQFDEDGERYVEKVVHGYLPELFARWADKGTSHVVTIIFFSRIFYRDDEVEYLRKHDMVNMLSQDYSGQWYKDFFKVAVDLERRNDWMSSLPEIKRQLEKSEREILLDYHLGLLKAKGVAEEEVKIVGKWCFAYQGNVLEAINLALNPFDEHYVDRDLSRTGLSITVVTPSTGHFAVDKNLLRLTTERMVDHGMSVDFVCLTKMPLHSVPLFSYVSHRPKEPVQHEDGITAKARPVVPDLLYFDANSSQARDTELADCYSLPSWVSTSFYAVTHDKPFREDRFVARCKMYDIQMLGILDHNLTTVTVPLLNIDDTPMPRRPLTVDDRKAIRESFDQSIFGGVPDSVKVGSSPLDSAPASVTASYQSARLLAEKAKGSASSMSLSKPKGSDIVNSSQLPPIKASSEFDDINLGKKTTPGSPSPEPSSLSLRRSSRRSRSPTKMVQVVQTSAVANGFNKDSSSLLTDSCPGSPTTMARSISPVPPLPPTREHGDLPLPPGDSLPVSALIERNSSPARRSVRSNTTNREYSGSGASTPKGTPARSLRNQPSKGFIPSWVFNSFKPLLTASKPSFAVPAMENVARTDVATGDDNRPSSPSPSVGSLRGRTSKGGPNPKPIITPSTPSPSRGQKPPLKPVKSIQTQSQTQAQGTQPLPIVAPPASRLPSPSEEDALSRSLRNKGHGLSRSPEDSSLRAQSNALVQSSRHFTVNPCKPSAETIDRVRDAGGRRWRFVLPTLTQQHIVQWPSLIAPACLPLTTDFLPDQKQSDELYTTGTYTVQCYLEEGQFLIRSDAAEINLSLAMMREMVSQRLSQNFQVIVQPHELTEPEKPRPLPIHLEKDADIGVELVSGGASEVLKKGQGAIWLSWANHIHRLLFHPTKPEIVVHWMTRKITHQTESVQWKGLVWPSGMKGYQEAFATFAYPDVSMKINYNHLDHLINGERTDFGPLRHWRTRFILIPSGREPPTFPGLMPKNENLGSNDLLWLGAQKVIETLNRYLLKRPEGTPQQRSLKIVATTFDPSTCVLDEELMMDLARQIHGDSSRDKKKKLEGMTLANVAELMCQPDNGLVIRTRWWESRQHVSSFNGFELREWLQNTFEDVTSREKAQEWAAELTNKGLIEHVTKSHGFLDYWHLYYRLREPYNHMYSHLAKKESKNKSWFSTGSKGSRAAPPSLTGSQTSSSTVIAAAVADPSQATTDLTTSQSGKDPVVGEQDQSQLAKIYLKVHKGELKNGGKKRKIMMTQKRVLDLDPGRKSDRAEVAILHADVVHNARNAFHFELNWLGVTAALLEELRQKLSAQAERYGLRFVETPVEQIADIPKKCVYRTPIPIRLALAPPIIPDLHTRLVAVAHGTGQAENYFEYSILTKKFGFVLDVEATDRYPENIEVVYSYRKDDVKYTYSQFCHKTGLALVQCVGGEAGFLWSDNRLVVSAPTRKGVGNRVDEARALRKELEDFCSDTEQLSKFYEEVLPPPPSTGETTPEERQDELEAKVDEEEEQPAPQEKTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVV1</accession>
    <name>A0ABR3BVV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_101913</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615241.1">
        <property type="nucleotide sequence ID" value="XM_066756464.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988771"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0252521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="72" mass="8238" checksum="26269173245AFBDA" modified="2025-10-08" version="1">MENPHEAEQAVLLERIIKNVDKSNEAIMELNHCLKEYLDSAGAIHITSQLFSNYSRNVLYNLETVNKLPKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVY6</accession>
    <name>A0ABR3BVY6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615177.1">
        <property type="nucleotide sequence ID" value="XM_066756400.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988707"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16279">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="102"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="481" mass="53457" checksum="09381065CA7A6E33" modified="2025-10-08" version="1">MSTSQPLQLLFLGTATSTGLPLTPCLTLSTPYPQKWSNMVPLLQDRERLPSRSPSLASTASSSAYSSSTYDPEGEWPKNIPCACCRSAVDPDVPEGWKNKRGNTSVLLRKQTAEGDWKNVLVDVGKTFREQAMRFFPKWGVKTIDAVLLTHGHADAYFGLDDLREWCVRQGSAIPVYLNKETFRAVEETFPYMVDKTKVSGGGDVPQLIWKVIEDEGEFQVEGIDVRVFPVHHGIYFHSVLPPTNAEPVCDPPAKLEPEPLICLAFEFDASVIYMSDVSGIPQRTWDRLLQTSSKRQPILPTPVDSRGGDETPRGVPKCQSISDLANLSISPRGPRHLERTRAHNVSVLIVDALWPTQAHTSHFSLAQALIVALRLRAANTYVIGSTHPTSHFMWEEICNSLTDRGGRDYEVRDHPDAAQAEWLVKKVWDKVFGEGEHEGLGERWIEEGGRVQPAWDGLVLEVGGEQGLERADLNSKGLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWF5</accession>
    <name>A0ABR3BWF5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_101876</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615204.1">
        <property type="nucleotide sequence ID" value="XM_066756427.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988734"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="160"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="431"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="576"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="665"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0252484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="695" mass="76603" checksum="ABF5AF0E84E8E5E4" modified="2025-10-08" version="1">MPTRLNLPTVFTTDQTFLSFVRKRHHSHHDPYLTSSFSSLTPKHGSTLSTMGPAGPSSAAVEEDTTSVLSLFREDYVAVKEKIKVMDYKQVWKRASQRHMYKWYAILIIAGTLTVLITVKHHAVVDFCRPITEKIRSWPAGWLIPIAVLIIVSFPPLVGHEIIGILCGLVWGLWVGFAILAAGTFLGEIATWVAFKRCCQIRAAKFEKKNRLYAALTQLIREKSFMFVLILRFSAVPGHITTAVSASAGANFWSYLLAAFLTLPKQWTIVYLGKAFGTTNRTNTIISVLTTVLTIIATVIAAVYIYYQMRLVMRRWALASPVHVESSTTSMILSECADEKGQNSLYTRRRWMAFNDSNEYVNGCEGRTLTRSWSMPEHMREEELKEWVRSLENESSAEYASSASTQLNAEPGDDSASASNIKINIQMELDSILPTPSPPVTPRLPGPSSGITKTPGLGAPQSVIGDSNFPSPSPSLLELNPPSAYPPTLASRQSSFTRRIPSDSSLYFDATVPGTSYPQRVGGREIADEADAYAIAHGARRPEFRRMRGDSRAALLGRPVDDAALHQCGSSWRREYSHSYGRSRGSSTATLSRNDIDELGRARGDSASTAGTGYSYGRPTLDDLGVVRGDGGYIRVDRPQRRRGDSSAAVLGGLVDDGLRTEVFGDGNDVRSYEGKGWAISKEDQEKHRAGDENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX49</accession>
    <name>A0ABR3BX49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614865.1">
        <property type="nucleotide sequence ID" value="XM_066757396.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989717"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33559">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33559:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17069" checksum="5FC008B60C5A9536" modified="2025-10-08" version="1">MSLQPKISIHYITIPSPLPSSPSFNFHLTCMANTLMIWVGTGLPTDAAGNAAGGAASMGSVEQVDNKLAADWSVAMPSRGNIPVTATPLFRSGSTDIALPMSQRLAKKFPSNQIHLSLSLPSSLTNQTGQSIDPYASKMVLVMEKKLGKWIEEVLSQEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXJ2</accession>
    <name>A0ABR3BXJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein regulator of cytokinesis 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614981.1">
        <property type="nucleotide sequence ID" value="XM_066756204.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988508"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="841"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="846"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="860" mass="93608" checksum="20A16FF2C9C78E56" modified="2025-10-08" version="1">MSAYLDEQTPHLRHLHAQLSLPPTALEQDLHRIEAAIKAVITSIIREREAQVDQLKDDIAATKSDLATLQRAVGDRRDREREKEGEEEETLPRQLERLNDQAVELKKVYDERLVHIKQQQSTLDRLSTLLGPPWQPMKPLEVIASSSRSRASSSSGMGVNANPSLGVDGKRSVSSSTQTIAQAIALGHAHGQAHTQSQGQDKNKGQWYDVRESVVEEIDQAVKLALAERDARRRTLCQSLFTLTWLHSELALPPIPTSSPHNFPPHLLPLYSEEEQPGLYASYERLLHTIITLNPLPPMDDGNEEWPVVDDLEGFKNTEPEIPLIEWVEETMELWTAEKEEHEARIQELYNLVEPLWTKLGIEQETMDCFVEMNRGSGEATIKAYEAEYERLLELRRASLSSFILSTRSTIVALQTSLLMSPRSQSTSFPAMHDEEYTEDLLHMHEKEIERLEEEVESKKNILPKVREWFRLVEDEEELERNEKDPNRFSRRGGAMLREEKLRKRVNGLKPKIEMDLLSLLPMWEEENGRPFIVSGRRVVDRIHDAMEEKELVKEAKKRAKQGLLPLHPAAAGPSRTLAPSKTIRATPSHASSSSSRSTRLTAVTAGTGNLYSKSSTALSSTSAAIGTGTGTTRLGKRPIGALASASATGPGPTPTVGNKRAKMAGVGLGLGTAGGGGGMGTSGTGGMGVGRGGRSVSARSAVTGGVPRGGVGVGVGVGGSPTPRHQRDFENYSQGQQQQRSVSYSSGIPSHSAAYPPSHTRLPTTTTTTTGAGGVKALAPAPKRGYNPLGGEGEVRRAPRKSFKPRSSMAPVGGTGIVNGVNSNGNGGGLGLGIEGLGGWREGLEGNDDGLEVEDDDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXR8</accession>
    <name>A0ABR3BXR8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT family small oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102312</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615639.1">
        <property type="nucleotide sequence ID" value="XM_066756862.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989170"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="711" mass="78236" checksum="F7438774FF6024CA" modified="2025-10-08" version="1">MIEQRKSAEGATYPIRIMSHANNVSSSPPPTTSSGSRPRTNRSRRPPLPPDTAASGINDLPRREFFSEGSDDEDYDDEDDEEEEDVFAFNRPVTAAQPIGAKSSGHGTAPPSGRPTTAGISWAQEAAEEEEPAHVGSSTGPGTLPYGGPTPLRDQPQSVDSNNKDTVPTPTGVIDVGGHLPDTTYDVNNPPPFSGKNNPNNSSFAFNITGRSYRPRSGQSLLDRIHKRRKPETGETSVTTMTALTGAHTDDSAVSDSVSTSDLEHYSQSPRRRISQGKRPVNSAPPISEDEVPSDDDTLDKRRGVSRGSIGMTELTGDMTVPDGMTTWGDGMGGLAKGVSEGEMQSTMDVDFDEEDSPYPEVRASVSNIDDPEMPAMTIRAWVLGIFLTILASGCNTYFHFRTPAPYISPLIVQVVAYPLGKFAAWSLPIDTYKFPRWLGGYEFSLNPGPFNIKEHTVIVMMANVAIGPAYALYATVSSELYYNHPMGFGFSIMFLFATQMTGFTLAGICRRFVVWPASMIWPGNLVVATNLNTFHAEEDGFTGGMSRFKFLMVCIAGSFAYYFFPGFIFTALSYFSWVCWIAPRNNIVNQLFGVSTGLGMGLLTFDWTQITWIGNPLSTPWWAAVNVGIGFVLFYWILTPILYYTNVWHTAYLPISVIQAADRFGDTYNVFNILTPEITPTRPHTPNILRYTSLHRTASHTWWLSLCRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYZ0</accession>
    <name>A0ABR3BYZ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615828.1">
        <property type="nucleotide sequence ID" value="XM_066755542.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987839"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="340" mass="38819" checksum="BB36685C6595A1FE" modified="2025-10-08" version="1">MEKESVFQSELELNRQIRQLQRERDLEEALQDQVWQLERAAVREEQGTWSRRQQGNSKSKDRADDDKWGNTQGFIRPPQAYELYQAIDKHDIDFIMRVRDHAFKLLLQKNGSEFPIVYAARLGEGWRDIVILLVGTLSRYVNHLEPEDFSKKETKDTLKGLRTNLKLAIDNSLHSSSPHLLSSYLQVLIMSEGDSFLHKAIYDLTLLLRASPLRTGKPVAHAEGMVRRFCTKELRGVAGGIGEVEEYVANAALDLVIMAVWSLAAGQLDLENLPTHTFARDLRTYQTFIEALQEKSAQISKANPRVRKMLKAVEELGGNSKKSVRGRLRDVAQFFDEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ34</accession>
    <name>A0ABR3BZ34_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615870.1">
        <property type="nucleotide sequence ID" value="XM_066755584.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987882"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF95">
        <property type="entry name" value="NUCLEOLAR PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="151"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="270"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0253649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="451" mass="49253" checksum="65D4A05938B2A884" modified="2025-10-08" version="1">MSKDSKSSTKVRAPKSERTPEEQAKRDAKKAAKKAAKFAENVPEPRSEESKAEEGEEEAAPIVEGEPTFPETKKRKREVAAEGEELEIDVSAPAPLSKAELRAARKKAKRGDVLPYTPKARDYEKVTKPNAQSGEGKEGEKDVSGSGKRQNSVWIGNLAFKTTPEGLKEFLEKGVTELGGKGDGSVTRVNLPKKSNKAGFSENKGFAYVDFATSELQELGVQLSERNFEGRRLLIKKGDDHSATANARTPKPLSTKAQDIGSSSKRPETSTLYMGNLPFDATEEALRDLIEGNAPEREIVDEEGAEEIGARGGKKSGLKKVRLAAFEDTGRCKGFAFLDFISARHAKFSLGNRKNHFFNGRRLNLEFASEEAAKRSGAARPKEKTKEKYNKHLGGSDVDDKSGENITEDLGDKRGRKWETSGRPRPGAALAMAKRENVAIVEGAGQKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ89</accession>
    <name>A0ABR3BZ89_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615863.1">
        <property type="nucleotide sequence ID" value="XM_066755577.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987875"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="325"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0253642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="444" mass="49979" checksum="969F26098A466CCF" modified="2025-10-08" version="1">MATTVQPIPPPFFSPYLDDQCNKINAKPVPWEGYQRAKLLSADELSLLKSLSKLPSAQRPTVLATQGSQYAKLYIDLLRKLQRVDTVQAVLVSISDMLADNSTIPYFHNLASPEYPDDPYGPIVKCLNMDEEFPVLGSLRILSLLIATDPKPFPNDLVPTLLSSLQKLLNGSRLPLWEVAAQVLGAILGTKQFRKSVWNEKNCLSGLIKSLKTNPNPQAQYWAITCLWQLSFEKEVAENLDKKYDVVAILTDVAKAAVKEKVTRVVVATFRNLLAIAPSQNLPSMFVTKLLPFIVSLQSRKWSDEEIVEDLEYLKDELKSRLDGLSTYDEYVKELESGHLVWSPAHETEDFWKENGIRIGQEEGGKAVKRLVELITTSKDPLVLAVASHDIGQFVKHGGDRSKQIIDNLHGKTRVMELMSHENADVRYQALMTVQRLMSQHWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ96</accession>
    <name>A0ABR3BZ96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615878.1">
        <property type="nucleotide sequence ID" value="XM_066755592.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987890"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0253657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="605" mass="65538" checksum="7CE356B218354B42" modified="2025-10-08" version="1">MSSEAPIALLSVYDKTGLLPFAKSLKELGFRLLGSGGTAKMIREAGMEIEDVSNITKAPEMLGGRVKTLHPAVHGGILSRDIPSDLADLATNKISPITLVVCNLYPFVLQTSKPDCTLAGAIEEIDIGGVTLLRAAAKNHGRVSIISSPSDYETIVAELKAKGEVSSETRRGLAIKAFEDTKSYDEAISDYFRKVYATPGVEDDMKAGAGVGYQRLALRYGANPHQKPAQAFVEQGEMPIKVLSGSPGYINLLDALNSWALVKELAAGLNLPAAASFKHVSPAGAAVGLPLDERAAKVFGVEDLKELSPLACAYARARGADRMSSFGDFIALSHTVDTPTAKIISREVSDGVIAPGYEPEALEILRKKKGGKYCVLQMDSSYCPPEMETRQVYGISLQQKRNDCKIDESLFRKVVTANKDLPKSAITDLVVATLALKYTQSNSVCYALNGTVIGLGAGQQSRIHCTRLAGDKADNWWLRHHPRVLSLPFKKGTKRADKANAIDLFVTGQAFEAEGGERAQWERLFETVPEPLTKEEREKHMKELTGVACASDAFFPFPDNVHRAKRSGATYLAAPSGSIMDKECIKAADESNLVFCHTDLRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZI9</accession>
    <name>A0ABR3BZI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616018.1">
        <property type="nucleotide sequence ID" value="XM_066755732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988032"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046424561" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="36"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="185" mass="20138" checksum="787BD0BEDEE890DE" modified="2025-10-08" version="1">MVAILTLLSLLLTSTFIASAPSSATTEVQDPPPGNGRRIRPYGRPDLCVMVGNGYAAYGTAVNIAYCQSNEAIWAPLQLWNVSNDSNGPIPLQSKIGDMCLSAGDNPVSGSRLTIDHCGNGQKQTWNYSAQNKIQLDSTDLCLDVKEGSGPINQNPYVIVKELQVWECEDDNNNQIFFELPYPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZL8</accession>
    <name>A0ABR3BZL8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium/sodium efflux P-type ATPase, fungal-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616047.1">
        <property type="nucleotide sequence ID" value="XM_066755761.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988062"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="843"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="876"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="924"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="967"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1038"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="10">
        <location>
            <begin position="34"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="448"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0253826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1090" mass="118079" checksum="45E18B0226D2411B" modified="2025-10-08" version="1">MSTENGQLNTNEKQLINRADTGKTAVSDSPLPFKPHTALSGKVLEALSSNATSGLSDEEVSRRLEKYGPNRLKPPKKPSVLKIIARQVGNAMTLILIAAMATSLGTMDWISGGVIAALVILNVSVGAFTEWQAEKTVASLESVGAPQATVVRTRNGSRDVAIKTIPVEEVVPGDIVQLKNGDIVPADGRILDGHLSNLEADEAFLTGESLPVAKQTEPIEEEDCPVGDRVCMVFSGSQITKGRARVVITSTGMGTEIGKIAQALDSKAKNKNRGFAAFWWKVKAILGVVETTPLQIKLNKLAYFLLACALIIAVIVVASTGFSDVPLSIATYAVAAAVSILPASLIAVVSLTLANASTDLASRHALVRRMDAIEALAGVENVCSDKTGTLTVGRMVVRKVWVPALDWRANEHAPLDTSGGQAYSFETGSDPFYPRGEVLADTQKITAAPETFDLKQPRDQSDSSSSDSDPDERDVEEQGRVIHVEEMENNLRDLALCISLCNQATLTRPVDQDGQWEASGDPTESALQVAAHKLGHGKPFLTHAAKPSQRADSIRSGHSSRPLVAGIRGRFVQIVEHPFDSTVKRMSVAYKFVGEDPQDSHVLCLLKGAIERVFERCTKIQGQPITEEHKKDVMSKVDALAAQGLRVLALCGKRLPVTMVDEVKSTPRDAFEADFQFLGLAGIFDPPRKESAGAVADCFRAGITPRMLTGDHPATATAIALTIGILDKTYSKNAVMTGQQFDSLSEDEIDQLPELPLVVARCAPETKVRMVDAIHRRGQSTVMTGDGVNDSPALKRADVGVGMGTGSDVAKQSSRIVLSDDNFSTIIRAIRKGRSVFKNLSKFLLYLLSGNLAEIIVLLIGLAFKDENGQAVFPLSPVAALWINTLAAGPPALALGLEPTAIDAMEQGPEVYHRIFTLEFYVDLIFYGFLMGSISLVNFVIVLWGYYPGNLGRFCNEDDPSICDPVYQARAACFATLVIVLMIHALECKHLSRGLAQINLRDNRVLLWCVIVLSLSTFPVVYIPVINNKVFLLGGPRWEWGIIFGMIFVYLGATEFYKWCKRIWIRRHALPSKGPSDKTLRMENTIAPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZM4</accession>
    <name>A0ABR3BZM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 11">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_100965</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 11"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615812.1">
        <property type="nucleotide sequence ID" value="XM_066755526.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987823"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="495"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0253591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="529" mass="57703" checksum="C53A092CCB3D2C14" modified="2025-10-08" version="1">MPVPVDDPTTTLEPTEGIEKPAKPAVKSRKRFVGSSKAATSRPVIRRVANQVPDDILHDKELNAAIAALPGNYNFEIHKTIYHIRRDNVQSVALQMPEGLMMYGCAIADIIERFTGALPMMLADVTYGACCIDDYTAKEMGAEMIVHYGHSCLIPVSQTTLKTLYVFVEIGIDTPHLSLSVRRNFPSSRSAFQRLILGAGEAAPGGKVPIALESTDESAQSNPDLSENDLPTRLALVSTIQFVAATQALRADLETAMPPLEKEEVEQEEEGMVAKVRRGDIGVWRGKYEVTVPQAKPLSPGEVLGCTAPKLNDVDALIYVGDGRFHLESIMIANPTVPAFRYDPYSKKFTREVYDHTEMRGLRGDAVKTARKNLDDQGSGSWAVLLGTLGRQGSLAVLKSIQNSLPADSIPPLLLLLSELSPAKLALLPNSQISTFIQTSCPRLSIDWGYAFSRPLLSPYEASVAVGRVKGWGGLSLENGKEGDKLEGEGDYPMDFYADNSLGDWTPRHNPPRPRPARVRPQAQACAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZU9</accession>
    <name>A0ABR3BZU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">20S-pre-rRNA D-site endonuclease NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101286</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NOB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616129.1">
        <property type="nucleotide sequence ID" value="XM_066755843.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988144"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="10">
        <location>
            <begin position="76"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="9">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="439"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0253908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="473" mass="51719" checksum="6C742DF55C996AFA" modified="2025-10-08" version="1">MVLSYSAIAKPTADTPKVISMATSKQVFPEASEALSAPAAEDPQEVESQAKALAQTSTSTTETAVSSEGREVIQHLILDAGPLLSLTPLRHLATNFHTTPMVLAELRDPKAREHWERLALTGVSVKVEPPTAEAMAQVTAFAKKTGDFAVLSMTDLSVAALTYQYEVMVNGDKRIRTEPPQAKKPGVKGKEKGLAKQAEKGDEEVQKNKNGKEEKPEEKDVRVERMTQSLNQIAIEPSTKTEFPEIDVPTTNESQTQTSTSAPVHAEDPESEGEWINPTNLSTHRSRDLGLITPSGSTAKPPAVACMTGDYAVQNILLGMRLGLVGEGGKKIGKVKSWVLRCHACFKICKDPSKRFCPSCVHLKQNFQYRTRGTIYSIPDPKMGRAKGQQKGGSGLILREDQREWQDAVRGDRIKKEKEEKKAAKGALEGWNDPDWLPEMITVGMSGKGRSGGHNMPSIGHGRKNPNQAKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZZ9</accession>
    <name>A0ABR3BZZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Structure-specific endonuclease subunit SLX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101337</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616179.1">
        <property type="nucleotide sequence ID" value="XM_066755893.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988195"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="9">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0253958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="421" mass="47406" checksum="A03206A9CCD2A8EB" modified="2025-10-08" version="1">MSGNAEETANKKTRSTLLDGNHVFPAFYACYLLRSKASANSNRTYVGSTPDPPRRLRQHNGELTQGAWSTSRHRPWEMQMIVYGFPSKLSALQFEWAWQKPELSRHLKIRGEDEEYHRIFTKDAKRNWVERKVCVAYALLSLPPFNRLPLHVLALQTVASAVTIILDLGGVSGTSGQRRESTKGVLSREGPIDVKDGEFRQGYGVWGKWLEIRKRIVSGQNLCCHLCQETITFNDHLTFSICPLTESRECFCITHLTCLAKHFLSETPIENRRGPSQLRLLPYQGVCPNCRRTVEWGQQIRACFARKGQVETAEKADRKIKKRDIKTKNGDQITGTVVEPESRVCATAVRASASLFNTSATSADPSMPVRPMECKDVDGESFCHSTHTDDSDGAISAYSVEDESEGKPEWEIFEAEMMALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C062</accession>
    <name>A0ABR3C062_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_101402</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616244.1">
        <property type="nucleotide sequence ID" value="XM_066755958.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988260"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046503757" description="Small COPII coat GTPase SAR1" evidence="15">
        <location>
            <begin position="22"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0254023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="189" mass="21368" checksum="3C609332FD050098" modified="2025-10-08" version="1">MFIINWFWDVLASLGLMNKSAKLLFLGLDNAGKTTLLHMLKNDRLATLQPTLHPTSEELAIGNVKFTTYDLGGHIQARRLWRDYFPEVDGIVFLVDSADAERFAESKAELDSLLSIESLAQVPFLILGNKIDAYGAVSEEQLRHELGLYQTTGKGKVPLRDIRPIEVFMCSVVMRQGYGEGFRWLSQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C086</accession>
    <name>A0ABR3C086_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA polymerase zeta catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616271.1">
        <property type="nucleotide sequence ID" value="XM_066755985.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988287"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="4">
        <location>
            <begin position="93"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="3">
        <location>
            <begin position="1118"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="917"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="757"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0254050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1296" mass="143641" checksum="43FA3C220E61EA93" modified="2025-10-08" version="1">MDDTAVINQGPSSSLPVGSTQSLCLNKPLLRIKITHITSDQAAPIPTLRQHYAPSRLATAIPLGNLPHSVPVIRIFGTTSSSQKICANIHLCYPYFFVPYPMDSQDPLRPERVVKLCQRFAVSLNHAICLALRQNPTSAGNNTNYGGGVDPKHLHVVSVILVKGTPFYGYHLGYDYFLKINLANPARLHIALEQLRKPNVLGREWQPHEAHLNHVLQFMCDFDLYGCGWLELGGGTFREPMPEGDPYDSLSETVTDGTLHIINSRTIPTSMLYPPGLSPAKETFTSIEIDILPHQILNRQRLIPRLLHHDFIELLHKPLDPNEKLVPAVAELWEDERRRRAAKGLGTDANDMMPGSGGMEGRSMEELGYRDNQADGKKNKGGNWKISDELWAILEERMDAERKRKGKLSFQRYSRDVSAGKEGEKLQWGKWIMTTFDALSAHWPKQTRKVTKTTQISRKSHMSPTADTSSIHNRSSPDNNALFGEPPSASFEGTEMDLALDKEDEEINPFEAFAMTLASQHPQPVPELSQRVQAVPFKDVDEYDQYYVGEDEDDIDEYKQAEGARVHAQETDKIRATQMPTEMEGSYDEYDDKELEELFRQTVAAGLGVQSVPTTPHKPKGKDQDEDGRWSGWTPTSKGSSKSSVGTFGSRQRKRNQRLLEDAGLGDLSTIIDRSSLSLSPLKNPYDERGHGLSTPKKANTPSREMATPSSLIRNAFTKNRQQSPNLSPTKRSESSRSKHLRSDTVILPSERKNLGAITSSPSLSPENKSIRGGRGNLQIKLAETQKLPQGSSPSASAKKGLFFGPESGHEVVQLSLPPAGAGLYEPIGNDVQPVVISGSHSVEVVEPHLSPTLLDLSSKVKASDLPFSATLLNAPSAEPASGPNFRDSSVNFFHERLPISPSIITIQRKDLEAKARPHKRVKLTEPGHASQESLLSPIRPFSHPSYGGGHRSPQDAKSDCQEALVSSLTSKSWQYCIVPPRRHEITDTMELHGLSTVDYQSPFFGQLADVPARPKTLAGKVFNLKSNSARNLQKFGCTIGSGSMLGNAKGKARAEAGWLKTNNDNDSVEKVRWNLGWEYSPSPPSTREVKHWCEKIDEAKIAREKYEQKTSQLAHPTQKSKYGFKYSQKRKVRDSSADPQSMSILTMEVFAQSRGTLLPDPEKDTITAIFYCYSSTDDDLPDTTIHPGYHAGYVVVGALANPARLGLDDIPFEVVEDELALINWVIDTVKFCDPDVLAGWELHNSSWGYLAARASGEFSMDMMDQISRVISGRAGPRNDGYSAHHSSTFKVAVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0K8</accession>
    <name>A0ABR3C0K8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3 8">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3 8"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616383.1">
        <property type="nucleotide sequence ID" value="XM_066756097.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988400"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0254162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="372" mass="40940" checksum="54A9F39EB6036F68" modified="2025-10-08" version="1">MLPPNLPPRRESPSPSANPSSDSDDAIRLTDDDAASSRLSAAQVGYLQDPFAPLLYKAPMPQPGGFGLQGGIRARKPPLINVGTHHRTWGIDLLVDRFLQSGGKQVVSLGAGSDTRFWRLMSRATPPDLVKYIEIDFPHLTSPKAQRIARHRKLYQYLDNSSGPSSTAPTMPPPGQHSYKVSKGGTQLSSPLYTLIPLDLRPSPYEPTSSISSILSDHVLPQLNPGLPTLFLAECLFPYMPPEDSKQIIKWFGETFGSCMGVVYEMVGLDDSFGNVMRRNLAVRNLSIPGSIFSTPESQAERFTSPVLEGGKFDNAGAKTLWQIREEDVGPEELQRISKLEILDEIEELRLVLDHYVIAWGTKGETMSSISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0P9</accession>
    <name>A0ABR3C0P9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine protein phosphatase 5 phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616434.1">
        <property type="nucleotide sequence ID" value="XM_066756148.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988452"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051982">
        <property type="entry name" value="CiliaryAsmbly_MitoImport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984">
        <property type="entry name" value="RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984:SF1">
        <property type="entry name" value="SPAG1 AXONEMAL DYNEIN ASSEMBLY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0254213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="76446" checksum="C876AB09A8020369" modified="2025-10-08" version="1">MSKSDSTQNLPSSFALPPQLLAQAADTYRHPAPPPQLPAVQLVPRHQEPVINPKEKHSPNGYPPNGAGVGIVRCPEGRAWQERNMHAGEKLGRFRDQDVDGFVADMAMVLRKEYDCWVEQCWQEAFHQVFTHTLPDLIINLIMTGATPSFLRRNIVFGGQSLDHLFQSQMLHILFEELELCLSGDRPRTRTEPGPSANTISNGGAKPSPFPLPPQPTAAPIFRDGVCFHNLSFQHGIPEEEDNHGPCLCQLTSCMTCFHLFAIMRRGPISLLPHELLNTPAAKGWLGGIETEAHARARQDSLRRKAPSQNTLPPGKGYAQVPKHGVSAPTAAKGNAEGGIGGEGGGKPLKPPQIFPHPQMTDVLAVEENLRWRLKELGATDPAVEGRYGPSTNSPAALEGVELPQGAGEESDDGGQQHPIGEGAGGTMNMNMNPAQNKNVKLAKVKGRGKMRRVVVPNGATAAAAAKNQKQNEKDLKKATVYLPKEWTEATVSERNTAIVLTFRHFVKLLHQIAMAASPFSHPDYPSDIEELLRMHPIALYRRLTEPAVERRYNAEEVKTWKSCMDKWAEEFGGKERKKGNDQSQDKRHSEAVRHYTRAISLDPKKTIYYSNRAIAYNNLSLHSHAEIDCTHLLARDPKNQKALYQRALARKGMGRWKEAHSDLEELLKLSGDNESAKNLLMIINKEMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C271</accession>
    <name>A0ABR3C271_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616087.1">
        <property type="nucleotide sequence ID" value="XM_066755801.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988102"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="2">
        <location>
            <begin position="114"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="231" mass="25036" checksum="4331D9F9D63FAF0C" modified="2025-10-08" version="1">MASICAACSRNLLSRPTIPSSSRLPTSLPRLRPPRQFSTLLSPCFKRRVPRSDAKSYRLATTSAFNSSRSGLPDLPPVPSRPNIKVSAPSLAAIREEGFYDDDVKLLPPEEAFLNITPEAIQQLTRITSREPIEVLSQGKLALRVGVESGGCHGYQYTMDLTEERGVDDYVLQPEGVACIPVVIDLTSFGLLKGATLHHATELIGSSFRLQDNPQAKEGGACGCGVSWEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3C6</accession>
    <name>A0ABR3C3C6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616240.1">
        <property type="nucleotide sequence ID" value="XM_066755954.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988256"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="716"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="789"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="728"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="819"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0254019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="935" mass="105315" checksum="42E311D5917D0059" modified="2025-10-08" version="1">MSDVDGKRRKIQRACDVCRRKKIKCEGPMNSLSDARCAHCEEYGMDCTYLEAAKRRGPPKGYVETLEQRAGRLERMLQQVYPGVDLNEYVGPKPDREEFDINAYHSTLRSLNIPPYPTLKPVHAEHLVTPHTSRSTSVGTSPAAAAPSPSMQVLGPSPWALYERDPAKPVENESDVEEEAAAQLSIATSMSQLDIRDSHWRWHGRASGAFLMRQFEDLKSATGGTSSIIQDINKHKRQQFWHVPEWELVIANEGLRPLDYSIWPEKGLDQQLIDAYFDNVNLHLPLLNYKFFQRQYDSGLWQNNHGFARVCLMVFANGSRFVDDPRVYWPANLSMTEEGRERLATDKDGTLRYSAGWKYLRTLLRMGRSIMQGPNLYEFQSQVLICQFLQGSAVPHFMWMLSGFGLRSAQELGIHVRATLFHADPTERALYNRAFWCLYHIDRYNCAAIGRSVAIQDTDFNADYPMEVDDEYWDTGDAERNFKQPEGKISLIASFVQTLKLDHIMGATLRTVYAINKLPEQRADINAQRAIVVELDSALNSWADNVPHELRWDPSRSDYQLFRQSAVLYIYYYYCQILIHRPFIPGPRNQHAANLPSLAVCVNAARSISNITDAALKRGRQEGCLPGRALNVSFMLPTWIAAIILLINIYSGRQTTAEREKALIDIGRCIAAGKELEMTWRQSGKYTDFLLQLARESGMPNADKVPAVEKRLRDGFSQLSEPSRRSESVQGLTAGTPVQDSSSNGHPYCQGRSNGQDSRSSDEQFRHPSMAPVAGFDLCNFTSPETYGDTSATPQFPYSRSDLPFTHIPSASASQTDFQSIFQPPSQPSQYPSNTSGVPPEFVPPSQLHPQYNFQAPNERNLPLQNDGQLASSNIYDSLIGMTSFESQLRDMSTTAFGGQENTSNGDWWSQLVNEYMGPDLHTNMSPSGGPLSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C439</accession>
    <name>A0ABR3C439_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616675.1">
        <property type="nucleotide sequence ID" value="XM_066754774.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987060"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="170"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="239" mass="26739" checksum="28DC231B579A3E08" modified="2025-10-08" version="1">MAIVEEIQDTSTLRSRAPTKDSKQKSKPNAQPAIPLVHPSTLPKPTVPPLLNVSSPGTIPDGAKVHTVSSAKEIEMLQKQLEEEREEGEDEEDEDEEHARQEEGDDVIFNTLIMAVPFTFLYLMLDILVHLQYSHRPGWYLLGEHVLKALPTLSLLVYYTNAYPTHPLTNSFLMSASILAGCRLIWLVNKASWSTVTAQAPPMGTLWIFTIVQLPLGRALLTLMFVGGWFWYSGLKFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C465</accession>
    <name>A0ABR3C465_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Carbonic anhydrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100219</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616692.1">
        <property type="nucleotide sequence ID" value="XM_066754791.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987077"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF13">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="8">
        <location>
            <begin position="817"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="9">
        <location>
            <begin position="1043"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1089"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1310" mass="146236" checksum="CE8173FDA2C7C4FF" modified="2025-10-08" version="1">MPFHAEPLKPSEEIDMDLEHSVAAQKFKEIREVLEGNRYWARKVTSEEPEFMAEQVKGQAPNFLWIGCADSRVPEVTVMARKPGEVFVQRNVANQFKPEDDSSQALLNYAIMNVGVTHVMVVGHTGCGGCIAAFDQPLPTEENPGATPLVRYLEPIIRLKHSLPEGSDVNDLIKENVKMAVKNVVNSPTIQGAWEKARKGEFREIFVHGWLYDLSTGNIIDLNITQGPHPDHLNHAFHTSLTYRAQPLPDWNLSTSYQWASPPPPPQPWTAPVPGKTDDFAPPSRLVPPFRSSRFRNGPDFTNQLKQAAKVSPAKDETPVNDAELQRLSASADDQHFDDVFAEEVAPDLDLENLKMEKLVVIKDWVDADYAPPDENISWDEALNISLPAPPPMDEFPDFFAAPDHLPKKSENTLSTFSLTVESGKSPVDHSTLMKDISVAMSLAADGYPPDGSTRFDWRTRALGQLRRPLPSHLRPRNRQWMYAKQPRRYQPVVSKLSNGHPLLLALQRYRRHFSQLLEAELQEETRLFNQRLEEWSTEKLVKAGYTLVNLRGHEVTRKQNPKGEGSFIYSFNRGKGAMIDAAKFTFGQYVMLSRTHPFQDAVKDNEDKFILATVNSKTKGAIQLVSPVPISDIHQGVWRLDIGHSDYVYKKQLEAMSFLNNNPLEQDMSDYIEDSDSFESYPQFPLDVPRGDHLMASTSSPTVPSDQVILKGTSLRETLLKAFSKTHLPPVLSASSLNESSSPISNVKFDGFVSGTQALSPTDLDATPKPHLALGTGKTQKSGILSRNTLIRSWAERHRSGRETPVEVEGDPHVPLNRTQLRAMGMMLSEALSLVQGPPGTGKTRVIVETIKLLKHHFQIPHPILVCAHTNVAVDNLLAGMVKHEVKAIRTGTAERVPTELKQHTLEIKMESHPMWISVQTMTEKAKRLKDEIFRMDFDNPERQQKNLEMKKIWRQIWGIQQIINRELLLDADVVCTTCISAISANLNSIDFPIVFLDEASMATEPLTLLPLMKGSSHVAIIGDHKQLPPVIVSEDAHAGGLSTSLFERLMHEKDVPSIMLDTQYRMHPSLAAFSSKTFYSSLLKNGTAASERPPPETAFLIPEDPIPDPSTGELRLSGEKTNLTFLNHSHPESPVLQSMANEGEAEIIVDVITDLLHKNPDLKGSQIGIIAPYLGQIKVLSETLFASGTQDSLKKILGDERTEEVQDVEIKTVDGFEGREKEVIIFSTVRSNPGGYIGFLGDWRRVNVGLTRARRALIMVGNKETLKMAKMGKRVAENLPQGGTKVWQDLMAFLEQGGMILDTDQGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4A3</accession>
    <name>A0ABR3C4A3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum-Golgi intermediate compartment protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616738.1">
        <property type="nucleotide sequence ID" value="XM_066754837.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987123"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="33"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="207"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49477" checksum="D4990EB93399458B" modified="2025-10-08" version="1">MYEPHLVDLANQHSHGDHEGMSLLEELDKIAPIKSFDAFPKVESTYMIKSKRGGVLTAVVGLIIFLLVLNDLGEYLYGAPDYAFQVDSDVQKDLQLNVDLTVAMPCRYLTIDLRDAVGDRLHLSNSFVKDGTHFDIGKATSIKNNPSSTTPSASEIISSSRRRTPNQQSSFSGIKRLFSSSSSSSSSSSNRRTAQGHTAYRPTYDKVQDGPACRIYGSVQVKKVTANLHITTLGHGYMSFQHTDHHLMNLSHVVHEFSFGPFFPAIAQPLDQSYEITLQPFTIFQYFLRVVPTTYIDASRRKLITSQYAVTDYSRSFEHGKGVPGLFFKYDLEPMSVVIRERTTSLFQFLIRLAGVVGGVWTVAAFALRVFNRATREVSKAVVGEKEYIPSSLHTPSPAMKREQSGSGYFTNDSPSTLVSRATSWVSGNNSSNPGGNNDLGNWKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4W8</accession>
    <name>A0ABR3C4W8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616683.1">
        <property type="nucleotide sequence ID" value="XM_066754782.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987068"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="452" mass="49627" checksum="5F6C6FBD14F2939A" modified="2025-10-08" version="1">MSPIASSASPLKSNKPTLSSQEVMNLEHEYSAHNYHPLPVCFEKGVGAHVWDPEGNEYLDFLSAYSAVNQGHCHPEILKTLVTQASKLTLSSRAFYSSNLGPFAKKITSMFGYDMVLPMNTGAEAVETAIKLARKWGYEKKKIPDGKAKVLSVEGNFHGRTIGIISMSTDPESRTGFGPFLENVGPRWDTGLIRYNHPEDLEKVLEKHGDEVAAFLVEPIQGEAGIFVPDDGYLAKCAEICKKYNVLLICDEIQTGLCRTGKMLCFEWDNIRPDIVILGKALSGGMYPVSCVLADKDIMLCIKPGEHGSTYGGNPLGCAVAMTALDVLVKEDLANRSLQLGEIFRSELAKLKSPLIKLIRGRGLFNGVVIDESASKKRRTAWQLCLLMKSKGLLAKPTHVNIIRFAPPLVISEEDVRKAVKIIGESLEELDTIEKIPGDEGEEHEAAIKLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C560</accession>
    <name>A0ABR3C560_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617037.1">
        <property type="nucleotide sequence ID" value="XM_066755136.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987425"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14501">
        <property type="entry name" value="PFA-DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF18">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23426" checksum="F8E390D533C3CEF6" modified="2025-10-08" version="1">MANKPPSQPLIQVPALFSIVEPGVYRSASPTPSQVPFLAGLSLKTIISLTPEHPIKPLLQFVRTTGISFVHLGLTHWRRPGTDWRPVRYEIIKTALEAYILDARAHPVLLIDPLGVHQTGCLVGALRMMQGWNFASALMEYRAHAGSKHRYVDEHYIELFDSDLINLPAPEYRPSWWLACDEAEPQKVEMLTSSNGGAGLLADANGPTQAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C572</accession>
    <name>A0ABR3C572_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617055.1">
        <property type="nucleotide sequence ID" value="XM_066755154.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987443"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="156"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="513" mass="57034" checksum="3B61066A5AA0CD44" modified="2025-10-08" version="1">MRSTQRRLSSLPPTIRSLLSSRRSTVPSISSTTHLETASCLNEPVEVNGWIKSVRAHKNVAFLEVSDGSTGENVQAVLKGKNRAEGLSIGTSAKLKGRLEQSRGRGQDVELVVGDAQVLGTCDAEAYPIQKKSLPASVLRDNAHLRFRTSQTAAVMRIRDALARDWHDWFESHDFVHVHTPILTGSDCEGAGEVFTIVDHPPPSSPASPQPFFPHPVHLTVSSQLHLEAPTHALSRTYTLSPSFRAEPSLTSRHLSEFYMLEAEVAWQDDLDGLLSIVEEGVKNVVGNILNGEKRGKRLRDDLTTVARSLHEVDDLESVTGGGQEVADTLDHLRQVVDKPFTRITYTSALELLSSLHANSPSMISPPPSWGEGISTDHEKLLAAHFNGPVFLTRYPKELKPFYMLPTPSTMKNEKTEASRGPTVECFDLLFPHWGEMAGGSLREHRLTELTHVIEEMGMKKEEYGWYLDLRKYGSVPHGGWGMGWDRWVGWVTGMGNVRDVVPYARWKGHCKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C589</accession>
    <name>A0ABR3C589_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617067.1">
        <property type="nucleotide sequence ID" value="XM_066755166.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987456"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045634160" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="154"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="225" mass="24031" checksum="CAC9FD4A330656A3" modified="2025-10-08" version="1">MISVQAFILILCFFASAAYASPRLFLEGCLKSNSAPANSLAISATSPSQCAIQCWSQREDTRYAYWDSLSDNRCLCSPFPANAQDFTLNSNEDRASEICAEGIAVYVRVEESPNFQVEGKRARKGRLVDVSLRAEGLCPTPLTACSVAGNTSIYECLDLNVDMSSCGGCVNGIFGSIKRANSAVDCTSLPGVALNAATCLHGQCRAFRCDSGYTLTNDHACVADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5V5</accession>
    <name>A0ABR3C5V5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617136.1">
        <property type="nucleotide sequence ID" value="XM_066755235.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987526"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045752265" description="J domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="410"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="522" mass="58295" checksum="F9733EBC9217FCCF" modified="2025-10-08" version="1">MKGSLLVALPILFLSLSSQVFGDPSVPSAAQIVQDANRLLAEGSYSAAARAYGEAIELDPTAHANYYKRATAYLSMGRHNAALDDFEQILKINPGFVQAHYQRAKILAKEGDFAKAQYELKAYIRTKSDSEAEELLHLITVGEAAEKSTLQAFEKGRWQVCVDHSTKALEVGPNSERLRRLRVNCATELGDVNMVYGDLSRLASLDPSTTYLPLQLSNIAYFIRASSQATAHIKQCLHFDPDSKPCKAVHKTIRSLEKDVTRVRNFIESGSYRQAIKILDGDDGLLIRFEKALDDATKPKDGLPPYLAPQFHPKENSQMRLDLYALACKASVMANDFGEKGASWCEETMSMNEENVDSWISRGERLLKIEKWEEAMRAMEKAFDLSGRSQDILPRVQKAQRLLKQSKQKDYYKVLGVPRDADERAIKKAFRKAAKLAHPDVGGSEEKMAALNEAYEVLSNTELRQRYDNGDDPNDPTGGQQHNPFAHHGGGMPFQFFQQGGGFQGFHQGFPGGGQKMHFQWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6K0</accession>
    <name>A0ABR3C6K0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sister chromatid cohesion protein PDS5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617238.1">
        <property type="nucleotide sequence ID" value="XM_066755337.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987630"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1167"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1180"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1200"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1237"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1257"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1267"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1279" mass="143844" checksum="C2A809DECF0B5681" modified="2025-10-08" version="1">MAPRASLAKLDFKEPLLQQGKRETSDALLKRLKTLRQKLAALEQDMTDTKSLDPIRKPLIQQTLLHHKDRGVKAYTACCLADLLRLYAPDAPYSDVQLRDIFQFFLTQLQVNLRSSTSAPQARPQAKSKTTEASQTTLTQRITDIPYYTDYYYLIESLATIKSIVLICDVPGSDDLMDGYFNEFMEIARPDMNKTLMRYMRDILVAIIEEASSLPAGVMDCIIGQFEMYASKSETPSFQLTVDVCNEVADKLKRPFYAHFSEIQLAHGRDPSPNDLKILSESHDLLLTINRFCPDTLLNTVPLLEENLKAADEIPLRQLSTRTLGHLFAQRSGADDPAKRYPSTWRAWLLKKTDKAVQVRLSWVETTLQILIAHPEVRRELEDAMVGRFEDPDEKVRVAICKVIGSLDYETALHHVRAKTLQVAGGRMLDKKPAVRTEAAGALAKLYELAYSEIEANNSEVVDQFAWIPQAMIAALFRGEATNEMRVQISTIFKTSIIPLPQDAEQEQAWVDRLLLISLHLDDDGMMGLKRMTNLVGYAQGNWPFSAFAGLLESYGGGENKQSEQSKSPLNFCINIIARTVYGEPEKAKKDLLSFADINELRLYKLYKTCVDITSSLSAIVKARNEFLRRVHQSHEDLLPTLTALVDMSAWNVLNHSSIPPLIRRLQRAESESIASAAAQFLGLMAKEGPPMYKSHVQELVAAVADKKNGRLVEIGFQGLAAVCKVYPELAPSDNRTIERATNVAQEGTPRQAKFATRFLARSKDAASHCSKLIDAILKTVANEVDGERQLTLLTALSELARSAPKTFERKSTEIIKYVMNEVLLKTSPSQEVDGDEWIPLETLEPLDHAKTIALRVCTYWSLAFARDEDATALIRPTLTLLTAVLSNDGMVNENTREGGPARCHMRLRASICFLKLAHVKTFDKIVSQQTTFELVGGTVQDPCYMVRHLWLKKLQAALSPQRLLPRWNLMPALAAMDPDQDNVALAKKILSAIPASCTRLSSAERIERIEMPFARLLHLLTHHPDFEWHEPGENEEDEESKKGITSMQNLKDIARFIELYLDCLAHRDNVGLLFAIAGHLKAVRDRFSDNNKPLYSLSELAQIIIRNRAEKHGWSVPVYPGKISMPRDIFHNAETPEERTKVLRTQYLSEEVRGWARGLGKRAVTVPSVRRATENNSPPRKRIRSSTKSSRKKRRQSETSDEEDSDVSSSECEVESEIEVEDEPEQDGEEAVLGRGGKRGAKTKANRAVGKKARREKAEKKKKDEEMDVDEGESEASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6T4</accession>
    <name>A0ABR3C6T4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616763.1">
        <property type="nucleotide sequence ID" value="XM_066754862.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987148"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="617" mass="66539" checksum="0350B3ACEDE53E80" modified="2025-10-08" version="1">MQLAMPSPDTTGARSLPPTTHPLADIDPLQPSARDISVSTHPQHTQDNFDPYTASLLRATRPSTDSHSLTSSTRTKSRSRPTTPNLSNGDDGQLSPVTKKDRLVVNNVRDRERAGKQPGEAAAVQNKKAKEEAALAKWRKWVIEHPVHAPPLAASAFTSGRSSPPGQKIPLVTLNTFTLRTYRPSDDDVHRAHSPRNGHFPYHPSDTEGSMSSPVTSLNVASPNVTVSPMSSSRFDSLGNEVYNTDSVLVLRDVELAVDEEILERTQRAQATLPRFVSNRPRLYETPNPFGDITHRLSSRRVRPIALELIQALGHLVDAVWLSTYPDRPCPWIIGLDESPIQSSIKHLIMAYRTPTDAYQTGVGWKSPMITAVQEGKRTGYVPTTIADSYIQFCENEVAYAIGDVDQVVGVSKGAGYIFGRALRVGEYGAPVRTNVLGASGEGGGMARLLNDLEEAIWGDAPPRVTDLAYELPDDFDPYAIPDESELIIAAAAAGGGSGHLTANSSSLVDLFRGEASASASAGAGANANGYAILASRRQSSQETGDTYDSLPDFDITSSLPDDITRISTPVEIVKNKLSGGLLPGIEDIRGAEGMTLEELGKKRHEEWLANRAAMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6X4</accession>
    <name>A0ABR3C6X4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616793.1">
        <property type="nucleotide sequence ID" value="XM_066754892.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987178"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="104" mass="11572" checksum="3489AA947AD27D57" modified="2025-10-08" version="1">MSSDVKYLVDKAIADNKVVVFSKTYCPYCKRAKSYLAEDTKDIEILELDERDDGPAIQAYLKELNGQGTVPHVYINKEFIGGSSDLLKLSHEQVKKKISATSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI04</accession>
    <name>A0ABR3BI04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610709.1">
        <property type="nucleotide sequence ID" value="XM_066761169.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993603"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="49803" checksum="3F80C5C697D1FF98" modified="2025-10-08" version="1">MTLASTQIGQTPDILQLICSYLPRSALFSCLLTSSTFFHCAAPELYRSLHIKHARDCFVGATRQSNSFYTSSPPSTNSPFSSATPPRPISPYSKDALLSFVRQVHIHTHGRNECPFVLHYINPLPHLEYVHLAGGVWPAELTIGDICEPETCQFLAKVCTRAKKAVIRQANLDPLKLLTHLEHVTVKIRPCQLPLYIFHDTAYLWSYPVPLYSAKIVDLVFWDEQHSFRIEWRTIPGGAMRSSLMGLRYQSPSPYLGGESVILKGCTYCDERGCIRHNPHAAVQLPALMSMLGMLFNVKTIRVWNVDRTAQRQWKQGMVSVDTVKGRMEEAWLNARSEYLKRIGHEDELDHQDQDQVAAGISFHSASEYFTSAQFDMETDQEEFKYWQNVVEPSPWILRLRREIRDMFEEDDAVFDQYSESELQGLVENGRWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIM9</accession>
    <name>A0ABR3BIM9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611048.1">
        <property type="nucleotide sequence ID" value="XM_066760776.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993200"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="220"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="430" mass="46891" checksum="ED80344509672DEE" modified="2025-10-08" version="1">MPDKTEYLLAINCGSSSIKGKLFAIPSFELLANLAVTNISSSDERIKIKITWEEGKGKDSEEESDYGDKIRYGSLVPTLLDHLTNSTHVKKEEIKYVCHRVVHGGTHDKGIRVVKGHEEGLAEMDKLSQFAPLHNHRAVLAVKSCLDALPHHTSLLLFDTIFHQTIAPEVYTYALPPADTELSMPLRKYGFHGLSYASIVQSLAEHLKKPSNQVNVVVAHLGSGSSSCCIKNGKSIDTSMGLTPLEGLLGGTRSGTIDPTAIFHHTKDAASDASVGDFTVSKAEIILNKNSGLKALAGTTNFGHIIQNLDPSKCSEEDHEKAKLTYAVYLDRLLNFVAQYLFKLLSEIPIESIDGLVFSGGIGEKGAELRRDVLKKLAWLGAEVDEEANNSNNGSTVKSITKEGSKLKGWVVETDEEGWMAKMAKVEFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIY1</accession>
    <name>A0ABR3BIY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106516</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610768.1">
        <property type="nucleotide sequence ID" value="XM_066760943.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993371"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="753"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1194"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1225"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1268"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1314"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1349"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1468"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="144"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="845"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1493"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1493"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1518"/>
            <end position="1529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0240269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1529" mass="170369" checksum="4022996AB5A95D19" modified="2025-10-08" version="1">MAFAGVGQGIGTYDRTEQASGAPLGRVTSRAHFTDIHPSDDLPAQTEENRAREVGHLARQLTRQSVTGTDDSADVFSYQEGSDLDPFSDKFNAKKWTKLMFEAVQTCGPARKAGLSFRNLGVHGFGSDADYQKTVGNLPLVGIGSLRDLVGNRKRKVQILNSMDGVLEAGEMLVVLGPPGSGCTTMLKTIAGEMNGIYLDESSSLNYRGITPKEIYGQFRGEAIYTAEVDIHFPNLTVGQTLSFAAEARAPRNPPGGISKKEYAKHMRDVVMSVFGISHTLNTIVGNDFVRGVSGGERKRVTIAEASLAGAPLQCWDNSTRGLDSANAIEFCKNLRLNADYMGISSAVAIYQAPQSAYDCFDKVSVLYEGEQIFFGKTTDAKQFFVDMGFHCPSQQTVPDFLTSLTSASERRPREGFEGKVPTTPQEFAARWKQSDKYQELLAQIAEFENKYPVHGEKYREFLESRRAQQSKHLRSKSPYTLSYGGQVELCLRRGFDRLRADPSLTLTQLFGNFIMALIIGSVFYNLPVTTSSFYSRGALLFFAILMSAFGSALEILILYAQRGIVEKHSRYAFYHPSAEAVASALTDIPYKVMNCIIFNLTLYFMTNLRREPGPYFFFMLISFTLTMVMSMLFRSIASLSRSLTQALAPAALLILGLVMYTGFAVNVANMRGWARWMNWLDPIAYGFESLMINEFHGREYECSTFVPMGPGYEDVTGQQHVCSTAGAVAGSSVVNGDAYINLSYEYYHAHKWRNFGILIGFFLFFTAIYLTATEFITAKKSKGEILVFPRGKIPRALLAQSTHSHGSSDDVEGGKFAGGSDMKKEITGADRANAGIIQRQTAIFSWKDVVYDIKIKKEPRRILDHVDGWVKPGTLTALMGVSGAGKTTLLDVLATRVTMGVVTGEMLVDGKQRDLSFQRKTGYVQQQDLHLETSTVREALRFSAILRQPNTVSIKEKYEYVEEVLKLLEMDGYADAVVGVPGTGLNVEQRKRLTIGVELVAKPALLLFLDEPTSGLDSQTSWNILLLLRKLTEHGQAILCTIHQPSAMLFEQFDRLLFLARGGKTVYFGEVGKGSRILIDYFEKNGASKCPEGENPAEWMLAAIGAAPGSHSEVDWHQTWINSPERVEVRRELARIKETQGGKVEAALQNKDYEKSKAEVKAEYAEFASPLWQQFIVVLMRVWQQHWRTPSYIWAKVALCSLSGLFIGFSFFKAGTSQQGLQNQLFSVFMMFTIFGQLTQQIMPNFVTQRSLYEVRERPSKTYSWKIFILSNIVSEIPWAILMGVIIYFTWYYPIGYYRNAIPEDAVHLRGALMFLYIEMFLLFNATFSIMIVAGIATAETAGNIANLLFSMCLIFCGVLASGSSLPGFWVFMYRVSPFTYLVEGMLSVAVANTDVVCSDVEFLTFNPPSGQSCGDYMSTFITNYGGYLVNENATTACEFCSMSKTNTFLAQFDIYYNNKWRDFGLLWVYVVFNVIAAIGIYWLARVPKNTGKERASEPEDVQEKLAPAQSTEKKYQSISRGSESTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIZ8</accession>
    <name>A0ABR3BIZ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610936.1">
        <property type="nucleotide sequence ID" value="XM_066761111.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993544"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="95" mass="11012" checksum="84F4A9705365548D" modified="2025-10-08" version="1">MMKSKDIFSTPLHIMRSLRILNSVNRPRLFKYDWTPSVLSYHPVPLNNNPALVFLLTQFRSSRFVRGLDPNILPEISTFPSEAKVFSSFISWVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ77</accession>
    <name>A0ABR3BJ77_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">argininosuccinate synthase</fullName>
            <ecNumber evidence="2">6.3.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_106576</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610825.1">
        <property type="nucleotide sequence ID" value="XM_066761000.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993431"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="9">
        <location>
            <begin position="183"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0240326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="429" mass="47421" checksum="E2B616A8752DD529" modified="2025-10-08" version="1">MVATGEKKGKVILAYSGGLDTSCILLWLIEQGYEVVAYMADVGQEEDFEAARAKAMKCGAVGFHLADLKREFVEELIYPAVQCNAIYENVYLLGTSLARPVIARGMIEAAVKEGCDYVSHGCTGKGNDQVRFELAFYGLAPNIKVIAPWRLPEFYERFDGRSALLEYAAKNGIPVTQTAAKPWSTDENLFHISYEAGILEDPNQTPPDDMWKLTVSPEKAPDAPERVHIEFAKGLPVKVTFPADGKTVTDSVDIFLTLNALARRHGVGRIDIVENRFIGVKSRGCYESPAATILRAAHMDLEGLTLDRNVRALRDQFVTTQLSQILYNGFFFSPEREFITAAIPASQKTVNGVVRLKLYKGNVVVEGRDADEGLYDAKFTSMDEMGGFEPTATSGFIEISSIRIKAWGRANIKRGQDGVSPKDVYHREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJC4</accession>
    <name>A0ABR3BJC4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611285.1">
        <property type="nucleotide sequence ID" value="XM_066760524.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992932"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037666">
        <property type="entry name" value="CCDC43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0241903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30201" checksum="514D91C51A60AF8A" modified="2025-10-08" version="1">MAPSKSPELSAPAESSGQALERYIIEQLSSLSLSAPQDDIEMMARFVEEEGLERDEKTEGVKGMLEGVIEGGVLPEEGLDEVLNQIIDEQARLHQHVLDRAAAEEEAARSPSPESFRVDDILATLTPEELAAARRQALLRQYAYVDSPDDAPANSPFGGEGRPEGAPPKGGKAAENEEKRKAEERRRLIEEALRKDSRKKKHRKNDDLDLLAPNLNKEKATYVMAMQREAQKKASQEKKDRDRAALEKQRADQAKAKADKQKRAAKQERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJE5</accession>
    <name>A0ABR3BJE5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 6">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 6"/>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611301.1">
        <property type="nucleotide sequence ID" value="XM_066760540.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992948"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0719">Serine esterase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0241919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="280" mass="30366" checksum="4A8D6C032B001233" modified="2025-10-08" version="1">MVQLEKLSSNKAAGGFLTKYKFPSASLALPTQFNVFTPSSASPESPVPVLFYLAGLTCTEDTGAQKGGFLNAAGKEGIALVFPDTSPRGAGVEGEDDDWQLGTGAGFYINAETDKWKKHYNMYDLIVKELPEVLKEANLGLDFSKWSIMGHSMGGHGSLSIYLKNPGLFKSASAFAPICNPAAVPWGTNAFSNYLSSSSSWLDHDSSALLPEFAGEPKILVDVGTDDQFLKQGQLQPKTLEKTVKKGVEVRMQDGYDHSYYFISTFGPEHVAFHAKYLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJF2</accession>
    <name>A0ABR3BJF2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611317.1">
        <property type="nucleotide sequence ID" value="XM_066760556.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992964"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0241935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="457" mass="50830" checksum="811C19FBA0322312" modified="2025-10-08" version="1">MTFSTRNAYYLRVSNYRVIPLFLYLDERHVDWMSDRVLQLVIASLQHKLPPLLWNARGEKKHKVHVERGEDYQFCYFLRSTTRTEVVLLKSKTVSLRPPTPPPAVLSEPQGSKRKRPTQSTRLSSKTPRQARASTRASSRARSVSVRYQDGDENDRTEVFEGENAMRPYDPDGIQVKAEPDPDEEDEFAGQPNIKDWKPDVDVTFKGFGTSSIQLVLIIEPYPPLPPSQYAPPSSRLSSRSASVMSSYSRSRTSQTRTRGEREGGRYSSTSLSLSVAAADGSRGGEGGGEGVGRDGSIANMRNASRAPSVANSRRGGTSTPFREESSTPGLSGSGGMGNRRRMSQTPLFMPRDTPFDEDEEDEEEHEMYLSALAEGRERLPSVFHPAGEGRGRGRGRGRGREEEEEEEDVPESVVDIGERLVRNSEIEEGVVRVQGGWEERGDGEESAVMGREEPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK58</accession>
    <name>A0ABR3BK58_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611546.1">
        <property type="nucleotide sequence ID" value="XM_066760242.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992648"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="594" mass="66850" checksum="46113D29D6F7D8B7" modified="2025-10-08" version="1">MSTAGNQQITDPIQIIGPSLLLQVFYSLPLRDLLNCSLVSATWYTLIDNHSTSIFRNLASDIVSDKKRIDFLKSLGQDEVRDPASYNASFIKAGTIGSDKKISWRGICRDAVVTDSNWKYGRAKPGWLTPGRNTVWRMKIDPEENVLYTVSRLDGIQCSSAEAEGSSGLLFEYTDIAPYSHMEFTGGFVIFNIGLANALEVHLTPCAMRRLTPEQRQAIPPTSNSETYGSDYSFTQENDAYRDARGSTDIPHRGHLTYYKTLRPATECWAFRARMDKEGQEGERPVLGTAGREAIYLFGLADAMVETIQIQHQHVDRDISYIEFDDDYVFICGPVAMHVYSRQTKQLLNFFPTSYLHDLDAQVQAVYELPESNEVRRLPSAFEGATRVSEITVKGLWKQDAAFENAERLISERMLLANGGFSACHFTSSDLFCANKYRVLFVVRDYKSVFSIIDKRERSEALSRNLLALRVNNPINQLYTNGERVVFNTTSEIYLLDASSLPPPPYDVSSSYFPQGAWPSIRILSFLDVHTNGLKHSSCLQMDGTKIYLVYWALGEQDGGGIVYDDGQAHLPPVHATADFGMCIKTWDFGHVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKR2</accession>
    <name>A0ABR3BKR2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_106000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611753.1">
        <property type="nucleotide sequence ID" value="XM_066760449.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992855"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="369"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="464"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0242371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="586" mass="65239" checksum="D7547551F0EC373A" modified="2025-10-08" version="1">MSTVTFENIFHGDSADLGKLRFNPVGFGWKAYQSEENNPTTYNGSDIRHATWFRVARHFQLRLGMRNSEKPRISFDGFKRDDLDKIKRTLQEYFNITLETRDTSLKGWNWGEAQVKGTDLVFQVQGKTAFDVPLSQVANSNIAGKNEVALEFNPSSNYKFDPKDLNKRPPDEMVEMRFYIPGKSMKTAGSDAGSGGEETELDEEGNEVSAADAFHSLIKEKADIGAVVGDSIVVFEDCLILTPRGRFSIEVYTDSIRLVGKSTDHRVPFTSIHRIFLLPKLDDLHVQLVLGLDPPIRQGATRYPFLVAQWPKDEVVNAELNLTDEELSQYPDLEKTYEATTFQVVSRVLKALTGKKVTPPGSLRNAQGLNGIRANVKAVQGELYFLEKGLIFISKQPILIDFSKTDSISFSRVGGGVASARTFDMRVVSKTGGANHVFSAINKQEVGPISSFLQSKNIRLKNEMEEATVDIDEPFSDDDEEMESPSEDERPSKAKNDKSKTVKKSADDDEDESEDEDFEDASSDGGSPSESDSDEDSGMASDASDPMMEELRKKNQAKRAKAKETSGSASEDEKPKKKKPKKDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL04</accession>
    <name>A0ABR3BL04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="9" type="ORF">I308_105918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611671.1">
        <property type="nucleotide sequence ID" value="XM_066760367.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992773"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0242289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="244" mass="27280" checksum="382B5E28EB824D8E" modified="2025-10-08" version="1">MAKTYTPEEAEALVHSHDPEHPANLICDLCREFYKLGWVTGTGGGISIRKDDVVYLAPSGVQKERIKPEHIFVLPFAQSSVPKPGSKRDFIRIPSKKGLNESQCTPLFWNAFTMREAGACIHTHSQHAVLLTLLLPRDSPSFRISHQEMIKGVRLGGVGKTLKFFETLEVPIIDNTAFEEDLTEGMAAAMAKYPDAPAILVRRHGVYVWGNTWEQAKTQAECLDYLFEIACKMIQNKIPLEGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL09</accession>
    <name>A0ABR3BL09_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611852.1">
        <property type="nucleotide sequence ID" value="XM_066759906.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992306"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="311" mass="33859" checksum="8D6002F40ED10B8A" modified="2025-10-08" version="1">MDRTADDTFEEGDSLFSLPGPSHPRSLYHTPSAANSRNTSHNAQANSLHFRHDDQRFPSPLSADYDPDGSSYGYQNASAIQGDEDLSGIADNGDSPSLEHEYEAALDRQTQMVDIPVEEAEGEVEESYDDASDGSSDLYDPDADPEAFSKRLDELAGVLEMNEVEQTALKWDPPIGKNHGRHPFLYSSDFKSVIKHYLTTTSWQYSSSSSFLSKMPCEDSLANGLDSRFGFGSGAFPASSLWGIDGTGGMVAGEIHPIRVLGRTWRDADEAIARGRSFAMETEDSAELDNETSRTSEMSPVLAAAVPNSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL17</accession>
    <name>A0ABR3BL17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NLE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611846.1">
        <property type="nucleotide sequence ID" value="XM_066759900.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992300"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="7">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="229"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="279"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="408"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="450"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="492"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0243479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="523" mass="57265" checksum="F03F6E555942306A" modified="2025-10-08" version="1">MATQLPPPKRQRSAYAQSQMPKVEEPAKDVPSIVVQFKSAEDGSSLGPAINLPADTARDALQMLVNKLRGEAEDPLPYAFHLVPKVPSTSTTPASARVQINNSIQSDALEVKNSTFSPEDVFELWCEPQAVFRVRSVGRCSATLTGHSSPILCCAQSPTGRYAATGSGDASCRVWDMETETPKWTLSGHKGWVLCVEWDSREKILATGGHDGQVRLWNPATGQPYGAPLLGHTKWVTALAFEPLHLVSKSSSGPRIASASKDGTVRVWNTSTRKLEFVLTGHAASVNCLRWGGENVIYTGSSDRTVKIWSGVDGKLIRTLSEHAHWVNTMALSTDFVLRTGPFDHTGKIPTSDEEVKKRAEERYKSVTSSHPETLITGSDDHTLYLWPDQASSSFSSTATPKKPLARLTGHQKQVNHVAFSPDGRMIASAGFDNAVKLWEGRTGKFIASLRGHVAAVYRVAWSADSRMLVSASKDTTLKLWNLKTYKIRVDLPGHTDEVYCVDFVADKVVSGGRDKTVKIWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL63</accession>
    <name>A0ABR3BL63_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611560.1">
        <property type="nucleotide sequence ID" value="XM_066760256.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992662"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="147" mass="15907" checksum="538B788F17613EE9" modified="2025-10-08" version="1">MRFPGDHITCPTPTGIYTFNNDGSDPTEIIDDESIYDAEAQGLKPMTAAYRSSNLAFDSLSEPLMSLAGGNMPIIEFEGVKMNLCMDDGQTSSESEEVGRPNKESTTPWASDCLEITLRNASNTPRDLGSHDIVTVSNGNQILQSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL94</accession>
    <name>A0ABR3BL94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611590.1">
        <property type="nucleotide sequence ID" value="XM_066760286.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992692"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="272" mass="30427" checksum="08F41F3FF35E3E75" modified="2025-10-08" version="1">MSVAAYTDAVMLFGDSLTQAWSAGSFAQRMSEFYLRRADVINRGFGGYNSEWALPVFEQVFATKKDREEGRVQQVKLITIWLGANDACLPSSPQHVPLEKYKSNVEHIVNLIRDPSSSYYSPETKIVLISPPPIIEAAWLESRLEKWKSFGCEGPEPDQNRDAKVTKRYAEGCKEVGVKLGVPVVDFWTAVVEAAGGEKDEQLAPYFYDGLHLTSEGYAVLFKAVSSQILATYPELNPETMPMRMPHWADVDVENPRAAFEKVKKGRLAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLE6</accession>
    <name>A0ABR3BLE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Short coiled-coil protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105587</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611987.1">
        <property type="nucleotide sequence ID" value="XM_066760041.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992442"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0243620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="9678" checksum="DF7B035E162E5338" modified="2025-10-08" version="1">MAFSSFAEGESEPWAAPVASSVPEPTVESALEKEKVIKDILSLRDGLRGLMVRLSEVEEENDKLAKENETLGVYVENLTRNSVVAAGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLJ7</accession>
    <name>A0ABR3BLJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611695.1">
        <property type="nucleotide sequence ID" value="XM_066760391.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992797"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="88"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="666"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0242313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="849" mass="94713" checksum="F9D5724545CFCDE0" modified="2025-10-08" version="1">MAPPPKISPVTGNPVPPHYIHSSTLHFQDVNGRALLLRGVNLSGSAKLPNNQPSHVREDFWESAEAGKGDFINRPLNLEDGSADLHLARLKAWGYNLLRYVFTWESLEHAGPKKYDYAYMDYIIAVLRKCKEWGFRVFMDPHQDVWSRFTGGSGAPLWTLYACGIDPYHLTPTASAYLHCEWPSAESPRPQDFPAMIWGTNYTHLANQTIWTFFFAGKTYAPKCIIDGKNIQDFLQDHFIDAVGELVKRIAEEGSDLMDECVIGWDSVNEPGEGLIGYKDLAVIPAEQQLKKGPSPTPIEGMRLGMGEAQDVQVWNFGPMGPYRGGRQTIDPKGVRLWLSEEDDIKRGSGKWGWTRGKEWALGTCIWAHHGVWDIATSTLLRPDYFSTLPTDPSRQVDFVNDFWALHWLAYSSRIRLHHPESIHFIQTPVLSQPPKLPQSFLKGRACSSPHFYDGLTLMTRHWNWFNADAIGVIRKKYWSIVQAVRIGEGPIRNMIQGELAVLKQDTVDLLGNYPTLIGEIGIPYDMDDKKAYGYVDGGRGEGDYSSQQKAMDCSMNACDGPNCLNYAIWNYVPDNVHEWGDNWNGEDLSLWSVDDKEQESYHDSSRSNTPNLSSSFNNLTNSSATLMVPMSGASKLCPSPSMVESGDFSPAVVLDGSRAAAAFCRPYPVATVGIPERIDFDIPSTKFKFTVRVRADDIANQTIYTEIYLPFVHYAASLDPSHSTGQNSISGQANSTSTEGDDSAFTSRQTSKVDLIEDERAIKSSDPASISIRSVPYSSSAQLSLDVAVVASHGRVEIKGQTLKWWYPVPEAGEEVKGVSSMYVPNVLLLRLCERSKESQIGHPSLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLM2</accession>
    <name>A0ABR3BLM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612029.1">
        <property type="nucleotide sequence ID" value="XM_066760083.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992485"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="151" mass="16571" checksum="B77DF3F12312BE2A" modified="2025-10-08" version="1">MRVGADAHGNLWELFHLLEDPAIELAVWLTRPKLWNDENEDEDEDEDEDEDGMRSPSVARIFGVDGVSMTAVAASIAGMLLENGVDECVSRHASSGGQVLLEATHLEFVGRSYDWSGKGKGKQGVGGENITVTGGLEKIKLRGMILWLFWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLQ2</accession>
    <name>A0ABR3BLQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612092.1">
        <property type="nucleotide sequence ID" value="XM_066760146.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992551"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="57"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0243725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="577" mass="63680" checksum="ADD6794489D2C283" modified="2025-10-08" version="1">MVKTHAPDREHIPPLSNFDIDLHPDTVKYVQDSQALADSLGSNGIRDVFASPIVFMAAFSACMGGLLFGFDQGILSIVLTIPQFLKVFPETDINSLIMVSNGVMTALLELGAFLGAMQAGFIADKISRKRTIMVGACWFIVGSALQAGSKSFAMLVVGRFIGGIGVGVLSSTAPTYISEISPPNVRGAFLALEGSSIVIGIVIMFYITYATRHILDSWSFRLPFTVQVVPCIALGIGLWLLPYSPRWLATVGRDQDALDALVRLRRLPSSDPRLQAEWITIRAEAIQQREVVITSHPHLQGGSGFVQDFKLEMHAWFDMFKPNIIARTMIGVMLMVFQQLQGINALIYYSPTLFQQLGLDYEMQLTMSGVINVSQCVATIVAFFLLDRIGRKPPLLIGSTINAICHFTVAGLIAKYSDNWAAHQNAAWAGVGLLIAFMFFFGIGWSPVPWALPAEVHSSSRRAKGVAITTCTNWFFNFIVGLITPPMLQSIRYGTFIFFGAFAVLSGIWAWFLCPETKGLTLEAVDQLFHNRTAHEELKQKHDIISRMIGMELTITPQSVQEDDEKKIYMTAHVETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM30</accession>
    <name>A0ABR3BM30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="7 8">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="7 8"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612212.1">
        <property type="nucleotide sequence ID" value="XM_066759565.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991963"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="7 8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="181"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0243845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="491" mass="53783" checksum="F180CB33E95A3BEF" modified="2025-10-08" version="1">MSSELADVGLIGLAVMGQNLILNMNDKGFKVCAYNRTVSKVDHFLANEAKGTNIIGAHSVQELCAKLKRPRRIILLVKAGKAVDDFIAQLEPYLEKGDIIIDGGNSHYPDSIRRTHELEAKGLLFVGSGVSGGEEGARNGPSLMPGGSDAAWPHIKEIFQKTAAQAQGEPCCDWVGETGSGHYVKMVHNGIEYGDMQLIAEAYDILKRGLELDEDEIAGIFDKWNSGVLDSFLIEITRDILKFKDTDGVPMVRKILDKAGQKGTGKWTAIDALDNGMPVTLIGEAVFARCLSAIKDERVRASKVIAGPPREAFKGDKQQFIDDLEQALYASKIISYAQGFMLMREAAKVNDWHLNNAGIAAMWRGGCIIKSVFLSDITAAYRQNPELENLLLAPFFTKALEKAQAGWRRVVAQSTLWGIPIPAHTTALSFFDGYRTETLPANLIQGQRDFFGAHTFRVVPGMGNDHLKENEDVHVRWTATSGNVSSSTYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMF9</accession>
    <name>A0ABR3BMF9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612314.1">
        <property type="nucleotide sequence ID" value="XM_066759667.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992066"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="56281" checksum="FFF768D3CC29C4B0" modified="2025-10-08" version="1">MFNTESARAAHLNSIWHNYRYHETHIIPFWTLCILSDLRSEAIHRRTGGQDYANVAQRFCTEIGLNIAAVPDNHWCSGLYFREVLRMRQETIKKILESPMIGLSDLLPSSTPALYVRDFRNVGASAPFHNNNQYDPVTSPKFAWGPPKLERSDMENIISAHDATFGDWEDIHVRVRDTKLFAIPTYRLLYKVYLPSGEIAVTDGELNDKGHNIIVDWPKGKAQPSNHDEYNNGLIFNRTWLDHPEKGIGNCLMGDQGSSSIVSTLFNAMRRGGPIRKETWEDDKIIPLIGSATVPHLQSLMKYTRKMLCGQGQAFSEPSFPIEKKATTTSSSSLFSKVDPTIRTKRSAASSPSPASSLSSRLFGASSFKSAAWTSSGSHSSKRQAVYEKFARAKAEKIGSSIYGPSEQYALRRLHDRNGYYAELGVENLAVELLDKSKEKEVNSILKEKYYTLCKIRHSDIGGAEEDQVRLNRAYEQVETYEQRRNYQLKPENCPSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BML1</accession>
    <name>A0ABR3BML1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612028.1">
        <property type="nucleotide sequence ID" value="XM_066760082.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992484"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0243661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="263" mass="29372" checksum="6115B85A9E0C9F85" modified="2025-10-08" version="1">MADFSAVFNSVPPVTRTILIGLAVVTFPCLLGLTSPASVALLWRRVTHGYEIWRLLTCFFFGGGGFPLLYDFFLIYRNSSSMETDTYRANTAEYAWLHIMMATFILIFNMFVGLPFLFRPLLHAQTYVWCRVNPTVKVSIFGLLTIPTSLYPIALIVLDLLTGGPPKAIGGVMGLLAGHLWWFLSTYVPLYAPSHLRHKNPLATPRFFKSWFINNSSNRRTFQTAGTSMQAQTSFATSSSRSEAAQEARHRWGGGQRLGGSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMV0</accession>
    <name>A0ABR3BMV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611610.1">
        <property type="nucleotide sequence ID" value="XM_066760306.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992712"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="555" mass="59003" checksum="F6429A9C85BDA258" modified="2025-10-08" version="1">MPDSHDLPAQSIASSSRQPPSNDSRAGQHASEAGPSRSASTDKSSHADVLNRPKIDHLGLPQTPASARALTSPTSELSPLSCSGTTPHLDICRYPTQQLLRLLAGLLQQIAGSNDQLRAELEAEEDEEMDDQHVDNDSSTANADWRSRPHSRASGRSYVASGASSAAEAFSESAPSTSTSSARASRSPSTVSNPTSYPLSQFPLFTASKASLSHPSALLAFHARHIPSISIEAYLLRILKYCPATNEVFLGVLVYFDRMTKLGTPAGIGGESAKVGKKGKGFAIDSYNVHRLVIAGVTVASKFFSDVFYTNSRYAKVGGLPPTELNSLELQFLLLNDFRLRVPVEEMQRYGDRLLAYAEEAGEDIGTVGVERRRSTTSEWGELECRHSEREFEGQTFRGSSEGGNSRPARPAMEKANSATSSTTTRNPASVASANAPLPNPISIKYASTQPPLPPNQSSTPVTVPTSPRIVQSKTQPRDAQRPQARTQTQPMKSHTFPVSSGGPSASVGSRAGAGNGVASAGSGAESMSGGIRDWVRGDDPIAVVGGRMTSPMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMZ9</accession>
    <name>A0ABR3BMZ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-serine dehydratase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DSD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612529.1">
        <property type="nucleotide sequence ID" value="XM_066759042.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991427"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06817">
        <property type="entry name" value="PLPDE_III_DSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="3">
        <location>
            <begin position="287"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0245445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="404" mass="44197" checksum="C832BDD782E70F4C" modified="2025-10-08" version="1">MSTFTSLSLYSLPSKSALVDEFVGQPLSALRTPALIVDRKKFKDNCERVASNAKERGMKFRAHVKTHKTTEGTRMQVEAAGGVKATIASTMVEVWQIIEAGLVKEGLVDDILYSMPISADKLEDINSAQEIVGKQATIRIMVDHAEQIKILQAFSQKIQRSIKWSVFVKVDGGGKRAGAPAENYVEIFGFYSHFGQSYASDSLSAGSSYFAGEINCVQTAAKIARNLGAKGKWILSVGATPTAHAAVQEAVKEHGGLEGELELHAGCYCMCDLQQCATSLVSYSRVAISVLGRVVSVYPLRKEAMCDVGALSVSKDTGRFPGFGRVVEPDYARGWDLGRISQEHGTLVHRQGEIIKEENELKIGDSVQIIPQHACLVCACFPWFYVVDDGRDEVVDVWVPWKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN23</accession>
    <name>A0ABR3BN23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612539.1">
        <property type="nucleotide sequence ID" value="XM_066759052.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991438"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="42199" checksum="6DD7CB017D0AFCE2" modified="2025-10-08" version="1">MSDYRQVPYTFNPSHSFGYFGKNPNAPTPPKPLTPPARPVPPFTRQSPSPPWPTTRSKLRKRNQGVKASLQEQIEVEIERERERQRLMNDYVIVEDDPNSSPIVPAEVFELPPLRPYTGFNFFSTNDVQFRATLMNRMSTQGPPSTLPVTMTSSPGSSFTDATNLMADMSILGQANSSNTTRGLSPLPEPSQGNIDPFSRALNAKVNRKPVDYGLVSNMPKPFHVDASEGCTYTCNTSPLTEVPKPINSEVVIDYSDMRTFSSLLTSVLNFRKDAEKMFWRSAELEGRIRNCAYAREGWELRPVMSRFNGKTVPEGCDVDEYIRTKQDIDMLSLEELSAWLELYGIEGFEQEGERRADRRRLWAFLVCNIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN55</accession>
    <name>A0ABR3BN55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066759759.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992158"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="436"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="448"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="82"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="1"/>
            <end position="23"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL0244039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="561" mass="60947" checksum="3FC0B41A1D7E3336" modified="2025-10-08" version="1">MSELPQTKTGDSGSSLTPSTSDIPSPEGTAVDVDAICKEKQLGQKSIDEPSPPSTKFEVQLEAQSQGEGNLTKLSPSRKWFLLLVFSVAQYLDVCSVSALFVLTDAIQKNLDIQYEASSWIITSYSVTFASFLLFWGRVADLYSAKAVFAYGFLGLGALNLIISFMPNQYAYFIFRALSGIAGAATIPSAFRLILALFEPQELNLALTIFGLSGAIANVTGLVIAGFFGFITANGQQAGWRWFFRMMAIIIVPFGVSALALIPKTAGDLSDRLSPRDKLKRLDVVGCFMMLVSIILLILGITLGASYGWKKPGFLVPFLLCWPIFVAFFIYEARLSEGYALIPPSFWKIPNMTLLIVFALGIYPWWCVSQLPLVERFIDYFNEPAIIAALRVFPQGASALIVAFFVPQLLQKVGSPRIPIAGGMIIGAAMYLLIIFNDGKLGSDYWRWLFPAFLIGSGAAMISFLATNITVMTSVPPEISGVAGAMLQVALQVGAAISLTVQAGLLTLNPGGMTNYANVQASLWFQFGWLLLNALMIIVFFRRSKMPKLSEEEGAAAAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN56</accession>
    <name>A0ABR3BN56_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
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    </dbReference>
    <dbReference type="GeneID" id="91991480"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="146" mass="16465" checksum="A349BDA42E3EF20D" modified="2025-10-08" version="1">MSDFLTETAVGISTDSNGFTCIESLAWDTIIKITIALMITEIVVGIAFLCIRSKRHRVDHEHGMVHAYKGVSSSGDFICLEQWLVITICITVSLLICALFTFITLSIREIWLLKQSRRGKDNEEDEKEQLMEIADEVGVSHKKMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BND5</accession>
    <name>A0ABR3BND5_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105194</name>
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    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066759651.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992050"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="115" mass="13319" checksum="6A00AC857AB7E083" modified="2025-10-08" version="1">MARCSSGANLINVCLSSWSLFIYPFYAHILITKSLITIFTLRNQFIEGLYTPLVPWNTLHGIGLLSLVLWVRYEVFRHRQVESHDETQKDACYLDYHIIPPVSCPPSMSLSLFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNG5</accession>
    <name>A0ABR3BNG5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612695.1">
        <property type="nucleotide sequence ID" value="XM_066759208.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991601"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814:SF1">
        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="541" mass="58501" checksum="5F49361C3255DFDA" modified="2025-10-08" version="1">MSLSFLPFTPSFVPTYILFFAFIGLNQTYAYPHNSRQDVGLTRNGSESSQEASQSILTSSGSALGVSSMAWNQPSSASATVSKIASVANGPATNERAINAMPTSSPTIVARDSSLEETSTSSMPVTTSFIPVSGLAFPSVTPCPSITASSYKTLTSLIPSILSNANSIAVHSWEIGAFTETLLEVYYPQLTPFGWKTSAFDGEDIPWSVLQIAKDAISHYDWTGAPGQNSEKNLQDYLFPDTTPQAHVSQALVGGDGALGDPVSLIPAVWLLARFARQDDLREELGLRSPGDYAWAVGNQLDYLFNGPTSDNGTISQREAGFEVWSDMGYMIPPSLAYLGLDISNYDLLKKALKQFSLESSAMLDTDQQIYQHIPASDARLWATGNGWMTYGLMRDLASVKMSSFAEDFSTLKSDAEQTIAGVFKALFDQLGEGSLLPDYMLQDNSTLALGDTAGTALTVAAYYRFLEIAPHLTSQDLTAKAEKAFDGVVAKIDDDGWVTHCVDPMGTYGWVVYSEDYSLHSPEGQAFAAMMWKARTDAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNN3</accession>
    <name>A0ABR3BNN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytosine-purine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104811</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612761.1">
        <property type="nucleotide sequence ID" value="XM_066759274.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991667"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0245677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="57768" checksum="3523DCD6031332DF" modified="2025-10-08" version="1">MSDKLKDSIEPLPISSESYELKDRRKSSSSNQVDYLPQYRDSFIKKKSRHGEGVVGLAKKTMDILVEHGVEERGIDPRPENERDELNKWTFLPQFTLWAAWNTNILSFSEGVIGPALFGLDWKTSCLCIVFFTAASALPVAYCATNGPKTGMRQMVQARYGMGYGLALVYGILNCATMIGFMALTAILAGQCLALASNSTMSWDVGIVIAALIALILSFVGLKALHLLSLASFPVMVILYVALAGVVGDKLYLVQSDVAKAATAVTASGVLGYGASLIGFSITYTSLASDFTTSLPPQTPGWKLFLCVYIGMIVPIILCQIFGAACQLAAYSIPDWETASNIGVPNLIYTMTGNGNGASRFVMVLFCLSVVANTAPTIYSAGLSGQVAIPWLVRVPRYFLALVVSAIYLPIAICGASKFYSALENFSSVLSYWSALYIPPTLIEPIIFRGPVSRKTYPVEIWNQIGKLPIGLAAIFAAICGIPVVTGGMAQSWWTGWIARKIEGTGDIAFEIGFVVVGLIYIPARYLERKFTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNP6</accession>
    <name>A0ABR3BNP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612776.1">
        <property type="nucleotide sequence ID" value="XM_066759289.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991683"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="8">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="7">
        <location>
            <begin position="81"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0245692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="329" mass="36117" checksum="4A53C7964358BB08" modified="2025-10-08" version="1">MEYISLLPQDVDLSSSHQYLRIPHPRTGEPQLYLPYITAAGQDVVLEAAKLNGSQRRTWFIGDSGIDAGTMLVHYPIDPLFIVIPLILALIPNGPPPPFQPLHDLLSAASTSTSFALPLPFTSAPKGKSPYESEVVNEDIERLLALNNVKKVFKACCEKRVISVAPPSPNPSTSPQPPTQSYYRPSHDLIIQHLKCKARFFATPEEFEKFDHLVRGLGKDGLLETDISEELLSSARLRAACDHLAQWLPAPVLSKLVNSYDFAALEEHLASRSAAAFAASQITTSSNKKEAKGTKRKAPPASRGVESLKKVNTSNIAKLTSFFKPKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNT1</accession>
    <name>A0ABR3BNT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="6">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_105525</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611925.1">
        <property type="nucleotide sequence ID" value="XM_066759979.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992380"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="13">
        <location>
            <begin position="11"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0243558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="456" mass="49491" checksum="628FD1DD034610BD" modified="2025-10-08" version="1">MASSNVPKIERLSCVPNDYPWGEIGNDSLAARLASKNGAVSFDLKPEQAYAELWMGTHPNNPAHLFLSPDILLSTHLKKNPSLLGAANRFSPPFTGAKGSGTEGQEEGHVPFLFKVLTCKQALPLQIHPDKNLAKKLHEENPEQFGDINHKPEIAICLSDRFLGFASFRPYENIVSLLKSVEETSLLPSSLQESIKSFTSAPSAETLQPTWEGFIKLGDNEESIKKFSGRVLSQGPKAFGDVHIEDEDKNRLVRAVELGKKYNPGDAGLFSSLLFLNLVELKKGQGMYVGADGPHAWLEGEIVELMAISDNVLNVGFTAGDSKDDPFLVAKAVTYTPKGIKDLLLDASQYSKSQNGRTTVYSTPFEEFSIMKIAGDEILSPLDGAGVAVVLEGEWTVEDQEGTKRGGEGADGEGGEGTIWFIGSAAETKWTAKGGKGEIWIAFYDKTAKQDDVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNT4</accession>
    <name>A0ABR3BNT4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104869</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612818.1">
        <property type="nucleotide sequence ID" value="XM_066759331.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991725"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0245734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="294" mass="32300" checksum="5CB3C606CB69A73A" modified="2025-10-08" version="1">MVTLLTLPTHLIESINDLLREDLELPDDLQGPLLEAINQPQTDVVAPLDIRHGLDSQEGGNVDGKQDSTAITPPPTIDFDLVERLSRWATSDKGKILLKQNELDPSRYTEISLLSGTEIYLDPKELERLRAAENPEKPNPYLPSYLSPAPPSFGSEYRNLTRTLSTTFNVLFSILGSAGAVYVAAVSGAGYSREKGILLGILSGLIVGIAEGVLVVLFMGRVEQDRKERHEKGRKLMKGSGKALDQIEDQTQVEEGVQGKLHSEGTESTAVPAKQIQLRRRGLKRKVQNSIREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNU3</accession>
    <name>A0ABR3BNU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfate adenylate transferase</fullName>
            <shortName evidence="7">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MET3</name>
        <name evidence="11" type="ORF">I308_104873</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The oligomerization domain is distantly related to APS kinases, but it is not functional and does not bind APS. It is required for oligomerization of the enzyme, although the oligomerization state has no effect on the catalytic activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612822.1">
        <property type="nucleotide sequence ID" value="XM_066759335.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991729"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="9">
        <location>
            <begin position="181"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="8">
        <location>
            <begin position="402"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for oligomerization; adenylyl-sulfate kinase-like" evidence="7">
        <location>
            <begin position="402"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="7">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0245738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="581" mass="64331" checksum="9974C72D01078616" modified="2025-10-08" version="1">MANAPHGGVLKDLLVRDAALHDSLLQEARGLNDIFLTERQLCDLELILNGGFSPLEGFMNEQDYTSVVETLRLAPFDGQKHGDVFPIPITLDVSQEDINTLGLKQGARVALRDPRDDAALAILTVSDIYRPNKANEAEKVFGADDIAHPSVAYLRNNVKEFYVGGKVQAIQAPTHFDYVALRYSPAELRAHFHKIAWRKVVAFQTRNPMHRAHRELTVRAARQRRANVLIHPVVGLTKPGDVDHYTRVRAYQALMPSYPEGMAHLALLPLAMRMAGPREAVWHALIRKNFGATHFIVGRDHAGPGKNSQGKDFYGPYDAQELVTKFKDELQIEMVPFQAMTYLPGSDEYQPVDEVPKGTPTADISGTELRKRLRTGASIPDWFSYTGVVKVLRESYPPRPQQGFTILLTGLHNSGKDTIARALQVTLQQQGSRSVSLLLGEELRSDLDPQIGGAITPEQKHINLERIGFVAAELTKAGAAVIAAPTAPYERSRQAFKKQVVGSGGGNYFLVHVATPLEWCEKVDRRGLYKAARAGEIKNLTGVDDVYEAPENADLVCDLRNDTVPEIVHSIIMILESQNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPE6</accession>
    <name>A0ABR3BPE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613032.1">
        <property type="nucleotide sequence ID" value="XM_066758584.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990961"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="92"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="264" mass="28236" checksum="E1F7EE15A968C4E8" modified="2025-10-08" version="1">MDVDKSLDDIISDKKQPKPQQQRRPHAPRHSAGNAPRQTPYARLPPKSTSEKWTHDAYRGPGAPRGGRPAAARFRASVPLTTGSPVLSRESPRIEIIGLHYEVTAEDLKSIFSQAGEIVTGPTIVYDRSGRSTGAAWMEYSNVQQAKTAINKFDGAMTKGQTISIRFAIPRFPPSSVRGRPGAGRGVAPAQNLLSRIQGAPGTKAPAPAANDRGVKGGRGARGGRGRGGNAGGRPRRQDVKPDDLDKELDSFMKQDAAGDVEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPV7</accession>
    <name>A0ABR3BPV7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613187.1">
        <property type="nucleotide sequence ID" value="XM_066758739.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991117"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36000" checksum="D772F586BD593157" modified="2025-10-08" version="1">MTFPSTSSIRSLRSLAASFSRTYATITPYSPPSNDYAPARRNPRPESPQFFTGRPEFHEALASLSSTVKHTTTVLREAHIYPLPTDLPHVTPPRAAWVSPEELSSIFQVKLKTSTLRQVMDLLSELHNLRHVSELAGYPDLAAKIDAALEKYERADMAEGKKDAKEKKEKRKVDEYGRAYAMGRKKTSSARVWMIPNPSARPFLQSAEGSSTDVLTLPTSEILINHQPISTYFPRLVDRETILRPLRLTGLLGAYNIFAFACGGGVSGQAGAVALGVARALAILREDSTDVLRADGALMRDTRMVERKKTNRAKARKGYTWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ71</accession>
    <name>A0ABR3BQ71_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612123.1">
        <property type="nucleotide sequence ID" value="XM_066759476.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991872"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="3"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="234" mass="26212" checksum="E973603EE5528135" modified="2025-10-08" version="1">MSLRLGDIAPDFEADTTHGRIKFHDWLGGSWAILFSHPDDYTPVCTTELSAVALSYADFAWRGVKLIGLSANNVASHEGWIKDIDALNPNAPGLDFPIIGDEDRTVSELYGMLDKLDKTNVDKKGLPFTVRTVFIIDPKKQIRLTLAYPASTGRNFPEILRVIDSLQLGDKYRITTPANWHIPDPKTGKIEERVIVHPSVQGEEVKLLFGEDVETVYPYLRFTSDPSKKEKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQC7</accession>
    <name>A0ABR3BQC7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104429</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613354.1">
        <property type="nucleotide sequence ID" value="XM_066758906.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991285"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="236"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0247393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="333" mass="35367" checksum="0F4B0823E601B789" modified="2025-10-08" version="1">MASLSASPPATSSKINLQASHHLLSGALSGLSSAVVLQPLDLLKTRLQQSQGGVGSKRQRIRGVVKQVIRDDGMPGLWRGTIPTLVRNVPGVAVYFYTLSAIRNRLSAVPYFSITVPVSGNKMSSPSGQVKREAGSRSAIVKLSSGGNLLAGAVGRTSVGFVLSPITVIKARFESNRYSDYHSILGALSSLYRTHGVKGFYQGFTATAARDAPYAGLYLVFYEKSKELAGKLPGVPNAALHSCSGIMAATLATIITSPADVIKTRMQVNPSEHPTLRKAVVRVAQERGLLGFFSGTSLRISRKAASAAIGWTVYEGLLIFLRDRKGQPQTGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQI5</accession>
    <name>A0ABR3BQI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Opsin 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104469</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613394.1">
        <property type="nucleotide sequence ID" value="XM_066758946.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991325"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0247433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35420" checksum="41E77D09E16ECDA9" modified="2025-10-08" version="1">MDYFAEFRPTTTISVNPPGGTNTHHPGPHHSHHLPLPTAPFPSATPKFLHATRVGHVSIWVFTAFFIAGLVAVLFLTSRTERKNRLFHGISAVILTVSALTYMSLATHIGSTFVPIYGPPGHHEPLVHFFRQVFSIRYIDAAITGPLIILALSRLAGVSPATALSAALAELVVVYSAWAGSVGGGWPWSEHGKGAGTKWAWFAVAILAFLAVWTVLLAKGRKAAVHRPRPTQGLFYLLSAMIIFIHIGQGVIWILTEGINLISVNVEIIIYGIMDVAGKIGFTHLLLLLHRSDEEGPWTLPAWWAEDPEGTGPDGRGIYGAVASVGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQW1</accession>
    <name>A0ABR3BQW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103638</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613527.1">
        <property type="nucleotide sequence ID" value="XM_066758125.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990494"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="11">
        <location>
            <begin position="1251"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="10">
        <location>
            <begin position="1983"/>
            <end position="2298"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="12">
        <location>
            <begin position="2328"/>
            <end position="2360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0247566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="2360" mass="267163" checksum="588C855FA7A85F0D" modified="2025-10-08" version="1">MSSQSDILDNIYQRLSARSEDVRGQAGQDLAEHVVASTQEYPGHDASKGVWAQVFHKTFEFTRSNNQLERLGAIIAIAQLLQLTKDDTPDRAQQKVLRLYEYLRPLTTCGDSTVMLPASLVVEDMVRNSPTLHTDTFLGKEVGQALVMIDDSRQEVGRFSGALLLYAFARAAPGVFHQYIPKVLEKIWIPLRDSRSVVRERASMLLSTCLDTLKTRGDRPSTDTYRKIFEEARLGLLKASSTESILGSLLAFNSMLQNQQLSMAEYYRSICELTFKYRDSKEVSIRKAVIALIPSMATYDSDDFEAHYLHRSMAYLLQALNRPADRDISYVALGHMAVHLGSKMKPFIDDIMRIIRDHLRMRGKKNAPYEAPIFQCLAMLATSVGPMLTRQMHEILDLMFPWGLSEPLCTALQATASHIPPLLRTIQDRLLEMLSQTLTGQSYRPLGAPAPRGGAQMDLNLLQSTTNAQSADTLKLALRLLARFDFVGHTLSEFVRDAALPYLEHDSVEVRREAVLATTTLFMTDPICQQTSSNSVEIVNDVLSKLLTVAITDPNAGIRRTVLDHLEDKFDRHLAQAADIRCLFIALNDEVFGNRERTISIIGRLAHHNPAYVMPHLRKSLINIVTELEYSTNARQKEESAKLLCLMVGAAAGLVKSYAPTILSVLLRTASSPDSSIGVQAECLKCIGELARVAGEELVPSVRAILDLVIEMLNDQSSPAKRDTALKTLGQIASNTGEVIKPYTDYPQLMGVLFRFLRMEANSSVRQETIKTIGMLGALDPFKHKTLLGDVDDPVDEGTTSRVNDIVLLNQHNSSVNDEFFQTVVIHSLVNVLHDSTYKDHYQAVEAIMMIFRTQRLRCVNFLPQIVPAFLNVIRIAHSSRTELYLKQLAQFITIVKLHIRNYLNDVFDLIHEFWNPNSSLQITIVSLVEAIAKAVEGEFKAYLPKLLQQILRSFDGDLSAKHLPELKLNTLLQILKAFYVFGESIEDYLHLVLPVIVRSFENPGAPDSLRIAALRTTGQLCRKVNFSDHASQIIHPLVRTLGSSSEELRQTAMETLCVLVLQFGPDYAIFIPMVNKALIENKISHPGYEALITKLLNRERLPPDLGPVERYASDSATEASAPEPVALKVNQQALKLAWDCSHLLNTNSRTEWISWIIGLGHEMMRESPSQAIRAARSLALSSVAFTKELFNVAFYSCWQELFESYQEDLWHNLDRAIKKEDVPGDVVNMILGATQFLEHDEKEVAIESRVLGSVAANYQALAVALHYKEQEFFLDPSKEVIEDLIDVNQKLQQSDAAWGTLEWAQTEMGMTTEVEWYEKLGRWEEALQVWNERDADASTTFSEWEITEGKVTCLHAMGEWEQLSDFVQARWANRTPEEKKLLSPLAAAASWSLKQWDLMDDYISAMKGDGADRAFFKAILAVHRNQIPAALKQISKARERLDPELTTLTGDSYGRAYDTVVRIQMLAELEEIIAYKDHADEPARQEMQRQTWKKRLAGCQRDVEVWQRILQVRSLVLKPNEDMDTWIEFADLCRTSDRLNLAEKTLTSLVGFQYPSMEDTRGRAPPPIIFAYLRMAWAKNLQIDSREERYETLQHLRDFTDQLTDDVGIGARGPNGRLMLPDQKLYGSYTKLLAQCHVELGQWQATLRESQGSADPSGILHDYSLATELDPEWYQAWHTWALANFEVITQLEVSQQGLSPIHFTTYIIPAVEGFLKSISLSPGNSLQDTLRLLTLWFTYGYSSGVTAAVSQGLPTVNIDVWLEVIPQIIARIQTPRQSIQQLIVQLLHDIGKAHPQALIYPLTVASKSTVAARRNVAQNITHKMREHSPKIVDQAELVSTELIRAAILWHEMWYDGLEEASKHYFGDHDIPGMLGVLEPLHEIVENGPQTLRETSFIQSFGHDLRIAREHLKRYRITQDGTEIQQAWDVYYSVFQRLGKQLKLLNVIELQYVSPKLMAVRDLDIAVPGTYQSGKPIIGIKNVIPTFKVIASKQKPRQCSMRGMDGKEYAYCLKGHEDLRQDERVMQLFGLVNTLLNNDHESAKRHLSIQRFSVTPLSPSAGLLGWVTHSDTIHVLIKQYRDQRKILVDIEHKLMQQMSDESYDSLPLLHKVEIFQYALDNTTGQDLYRILWLKSRNSDIWLERRTTYTRSLGLNSMVGYILGLGDRHPSNLLLDQITGKMVHIDFGDCFEVAQQRDKYPEKVPFRLTRMLIHAMEVCGITGNFSRSCEVSMEVLRDNRESLMAVLEAFVYDPLIAWRLTATDKRPGGVGEVKDLDDPAAYGKQRKNKANETEILNDVENTEVKNDKGLQVIERVRRKLTGRDFKPDVVLDVKSQVEKLVVEATKTENLCVAFLGWCSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR04</accession>
    <name>A0ABR3BR04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="10">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103698</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="10"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613582.1">
        <property type="nucleotide sequence ID" value="XM_066758180.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990554"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="11">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0247621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="339" mass="36307" checksum="2341C3CEEFE8F976" modified="2025-10-08" version="1">MVVKVGINGFGRIGRIVLRNAIEHGDLEVVAVNDPFIDLDYMVYMFKYDSTHGRFKGSVEVKDGKLYINNKAISVFGEKDPANIKWGEAGAEYIVESTGVFTTTEKAGVHLKGGAKKVVISAPSADAPMFVCGVNLDAYKPEYKIVSNASCTTNCLAPLAKVIHDNFTIIEGLMTTVHATTATQKTVDGPSHKDWRGGRGAAANIIPSSTGAAKAVGKVIPSLNGKLTGMSFRVPTSDVSVVDLVCRIEKGASYDEIKNVIKKASESPELKGILGYTEDAVVSTDFVGSTESSIFDAQAGIALNANFIKLVSWYDNEYGYSRRVCDLISYIAGVDAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRK7</accession>
    <name>A0ABR3BRK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613781.1">
        <property type="nucleotide sequence ID" value="XM_066758379.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990754"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="272" mass="30058" checksum="327D5448010677E9" modified="2025-10-08" version="1">MALYAPPPPSYQDRAAGPVQHHGFNPYSDNGGSILAIAGKDFSIIAGDTRQSEGYNIQTRYARKVWQLTDKVVLATNGFAADGNNFVKRVKQRLEWYEHDHNKPMSLKSIARMIQTMLYGKRFFPYYVYNILGGIEEDGSGAVYSFDPVGSYEREACRAAGAAQSLIQPFLDNQVYFKNQQPEPGAAPFVPGNLPLSTVLSLVVDSFTSATERHIEVGDGMEIYVVMAKGRSTDDLLGEGNLLPGMEVEELHPLGEGDGERSFLVKMPLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRT8</accession>
    <name>A0ABR3BRT8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613558.1">
        <property type="nucleotide sequence ID" value="XM_066758156.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990527"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119:SF0">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACB" evidence="6">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="242" mass="26391" checksum="58EA4B4599E934C7" modified="2025-10-08" version="1">MSTLGVATKIQFEAASSWLTSTPAAAGLPNETKLELYGLFKFITTGTGPTSSRPSIFYPTNRAKHDAWNSVSAKYLHLNSVPDQTKAMAQGRYVEIAKQVGWDGVIQEEDDIDLERLSDSESEDGRDGSEGAKNGWRKVSVMQGEDGLDDIGTSPIHDAVVADSLRVVKELIETDSSLINSRDEFGYTPLHLAADRGYPEMTKLLLELGADKSLKDQDDQTPLMLAQISSRDDIIAILDSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRX7</accession>
    <name>A0ABR3BRX7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613859.1">
        <property type="nucleotide sequence ID" value="XM_066758457.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990832"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="637" mass="70593" checksum="A8C1E2B33E4C8F1F" modified="2025-10-08" version="1">MTLYHGSTLLSAQYPPRPSRRIEQDASDSDTFFIPDRSSDGGSSSFISLIGGKLILYLAIPLFIIFSISVFIFWFIRRRQRRRLHRDSRRGPQESALSLQVSPSVIMGPSPREKQPYFPYTSRSILTMSLRSGRNSPRLSIEEDVFISYNKAKEQGLSNKWYNSQTTLSPLSEKNGRIEKRFFAPDFGLSVVTKGARSERSQSPHCPSRSQRSGSSGRSGYSSAQPPWKSGLETRDAREERDEGMMWVSEDNDPMTSSMYSPARTFITHHTSSDAGNSTHGTPTPIHPQLTGDHVHFTNITRSSSHPTVEQEKTNVFSSPPAAFVPGHSGRNIPQNQLQRMSLNEPLPSPTKTERASTIALSDIISIFGAPPASERRMSMMTDHTSNTASYPWFSHPESVGGGFLPPLPTISTYPRFDLASIISSSGSGGPTPPTVNTDLESYQFELRYLTPRSVSGLGSEMRSSRILTPPKRTPSFVWSTYSSPFHSPSDTNPGLNSLSYQTSTSISTPYRTSSFIHFTLADATMTSQAPVSYTIPVREGPVGGITGMSGEGELGRHKRNLSNWTHLTDRSAARPDSEVMPFENFIHSLNTAAMVEAETQRVRDGRSRILKERSKVWEISHCGQSSNLSFTPLFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS27</accession>
    <name>A0ABR3BS27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Siderochrome-iron transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613954.1">
        <property type="nucleotide sequence ID" value="XM_066757570.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989925"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0249767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="68255" checksum="67BDC8758CB68750" modified="2025-10-08" version="1">MSAPYRQQEDRAEYDDPNLPRLSEHEFEDSSSEFSEDPKAPVKRGITSASRILSVITKKDIRIAYLALTLLALGMAFAQYTEATFTAYAASAFKSHSELAAAGVVAPVFSMITYLIFVIMSGVFLLGLSFPWSSSLDAMMAGCKNVQTYIGANVFSGLSGTGYTIVLQIYYAETTAIRERALWNVAADSFTSGWRWGYGMWSVINAVLAIPFIAILFSWHRRVRHSPNVPHLPPHASIVDQLFHEYDLIGSCLLVVSVALILIPLTLAKGVASKWTDDNIAMICVGFGLLVLFIAWSTPKRWRPKWLFTPRLPLIPWYTLKNRSPMSMFVINMCDFMSYGAFTTYFQNFLQVAVRTSASKASMIDNTLRIVFQVTELVVGLVMRFWTPACIKLGLGKRLFHTRYPVWIGIPLCALSIGIDINFVQHPRRKSAIASYVIAKAIYGMFQTSAQITVQASSRRRELAIATGIFYFAASLGGAIGVAVAGAVWLNTLPGALVKNLPASRRFHGSITVAISYDPNFEIGLAILKSYVHTMKILAIVATCLQIPMLISMFFIEDLQLTEDEQIILAGKRIGLGKKKQEKVDEREGEEEVKIVEKEKPVVKADKVSLKGDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS74</accession>
    <name>A0ABR3BS74_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_103810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613693.1">
        <property type="nucleotide sequence ID" value="XM_066758291.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990666"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0247732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="112" mass="12988" checksum="0DB845C02CF6F2C6" modified="2025-10-08" version="1">MDPEGRSPSPEHQGVKFPRFGPDGQPLKAIIKSVDMSEDMQQKVVETVFESFGRYDQEKDVAMYVKKQFDRLYGTTWHCVIGKNFGSFVTHESKNFIYFYLGRVAILLWKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS76</accession>
    <name>A0ABR3BS76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein mL59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613831.1">
        <property type="nucleotide sequence ID" value="XM_066758429.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990804"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="2">
        <location>
            <begin position="44"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="198" mass="22686" checksum="DDAFF7E85A5E41F3" modified="2025-10-08" version="1">MPSFPTRLFATSSRLSAELTAAHATHIPAFNLPPVLYRRIAKHISQLRAAGETTQTVSIPNPFLLHRSTEKATYASRDSYSWHKPQISPRRQKQLLQFYPAEELPVSALNPQSEKRSIVWEDGTIVTWAGKVKEKTQKVKQGPYAGRKIMFKGHLDERKRPQKLAERQERLDGMSKRIADWRKNKADEKVKGRSSLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSF1</accession>
    <name>A0ABR3BSF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103155</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614039.1">
        <property type="nucleotide sequence ID" value="XM_066757655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990011"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01702">
        <property type="entry name" value="PolY_Pol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="37"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="12">
        <location>
            <begin position="624"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="509"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="585"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="671"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="678"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0249852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="714" mass="78645" checksum="4A2C968AC62A76FC" modified="2025-10-08" version="1">MPILGGLSRKNEGGVVPTYRHLLSPQALTTANPLRTVAHCDIDAAYAQFEQVRLGLPDDIPLICAQWQSIIAVNYPARKYGIKRFTSIEDAKKMCPHLVVQHVATYRNGENEAGYWDNVDPRTHKVSLDVYRRESLRILAIFKEKIPRGEIEKASIDEAFLDLTPMVIEKLLAAHPYLSKVPEDAPNGLDSPLPPPPPIDWSKAGSVFPIDGKEDGSGTDDEEGGQEDGRSEDGEGPDARTSSSERYSWEDWALCMGGELMSNVREEVYLRLHYTCTAGIAHNKAMAKLCSAWRKPNNQTILRTAAVPAFLNGRNFTDIRSLGGKLGAAIAQEFDAKTVDDMLTVSLDAMQKKFGEESIWVYNILRGIDHSEVMERVSTKSMLASKSIRPAVTSPHQGYHWLSILAGELNVRLRQSREVTPGLWPKTLVLSHRQGIEPSRSRQTPFPYTRNLSTDYILKYAKKLWDEATQPMLKGNMKLNVIGLSFTGLEKLEDGQQGIEGFFNNAKPKTAAESARKPSSSTTAQVISKLNSTSKRTRSPSLDSFSSTSTSVQLLPLGKDRPTKPPPLKSKKGLDAFLTKKASNLTSSSSHSNISTPSSASVSDLEITPSEPPQSSHISSHTKADMDSWACSECGQIFTVPEELYLGDGGVGLLGSMKQEHEDWHFAKSLQDGRDSISETSAPSQSRSNVGSSLRKKGKRNVEGIRAFFRPKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSS6</accession>
    <name>A0ABR3BSS6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614196.1">
        <property type="nucleotide sequence ID" value="XM_066757812.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990168"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="835"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1211" mass="132723" checksum="40E3040D25B5201B" modified="2025-10-08" version="1">MVKSNQPLQIRLTEPVIFLKGPSTGLDFRGRPQTVRQDGQPAMLRGLLTLRLNKPTRIRSITIKLEGKARTEWPEGIGAKRMETCEEHVILLEQATFFNAYLHDSSRSGSTRRASSLGPGVRVNHDDEQIDDDIDLAYVPRDEEPDDWINLGRRGSEERGRNMVRSSSAMPGTHDSSSWHRDGFSRRPSFDNSARNSLLDLASLNLQDRGPSPAYTPTASPPRIHSALPSHIPHPFAHRQPTSPHLAPSRGPDLSPIASVSPSQNNSERGDSADTEHRRPAHHMRNVLSYDALREETHLEPATPRSGPHTQNDDSMVGTIQGENNLETLPSPILADSQVNSTTISPYAEVRFQIPGIANQTTNQAEPNQQSEEADEKKEGTAITEPALLTEEPTSVAPPSSTSTEAQNVSSSAPTGGDNRAASIRTFNSNHSASTTSLLSLRENSTSENHPINSAVQTISSVSTPAQTSPAPSGPPSMRARSSFDSPENSRPSSSRPSSISFPGQHRASDQQLHGFASHPSSESLRQDRTRTTRADSTSTIVENGSSRFAASSRTSSRAREHRTPSGTPSLTAAPNLAHLVPSSSSHDGNDDGRGRKSHKFSLAATLRGLSKDVKERVSHPQGRSKSRTRVDKHLRTDSMHDSFDGSSSSIFSPPMSRGGSSSALALSEAGRGSVTHGSRHSSVRHDDFTPPHGRDEAGSVRRNRSKDRISSTVGGREQERNRSRARGRHMGMKVLTDKLGLGEHEEQEKGEDVHNWKEFRKGTYNYPISFPIPVNAPPTIHAEFGSVVYRLKATVVRVGALTPNLTEDTEVTMIATPQEDDLEETENVIVERQWEEQMRYQITLGGKAFPIAGTIPISVRLMPLLKCKIHRLTVALEEKTDYYAQERKVARHETPKRFVLLFVKQPDLKERTEPLLPIISDDPNAAEQSPLAEMARQAAMSDPPSDAFDLERDPNDAMYASLMEPTGPWHLEKDLQLPDCSSKIKFTTKHDQTNITVAHWLKVTIRVERGDDEALDSKGRRKQFDIIIETPIKILDCRVNPQYNSLPTYSLTQRTFHSVPGICAIHTGKAVAPIGVARPITLPPSVEASMSAATSPSMPSGLLGTGSHHHHLLPHRDHRNSESQATHGVSSSAPGEGEDTLLERNIVYDRLISGQLTETGEIPPTYGEAMADAVRERSVSHVRGIDSTSGIGGRGQSGNRGSRSHSRFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSV9</accession>
    <name>A0ABR3BSV9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103342</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614225.1">
        <property type="nucleotide sequence ID" value="XM_066757841.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990198"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="153"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0250038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="310" mass="35216" checksum="DBF7EA8A431352F4" modified="2025-10-08" version="1">MVAITVSVSGKPTINLDFANKHPRDVTVKELKAAIHAKFPKLIANRQRITVPNVSGKPTPLTDENKSLADCGVGEGAKLKLKDLGKQVGYRVLYLWEYAGPIFLNPLFLYYSHLIWGQYDPSPLQLTVRNLLVIHFIKRFLESAFVHSFSRATVPLSFVFRNCLYYWGICGFLIGLTLYRPGYSKQALDGTLLSDSRWINFWTVFELVAELLNLNAHLHLRSLRQPPGHPRKFPTGLGFGLAVCANYWFEILGVIALVAMTGGDIGTVIYLCIGTFFMKTWADGKYARYKREFDNKIFPGKRYRLFPPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTC5</accession>
    <name>A0ABR3BTC5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614390.1">
        <property type="nucleotide sequence ID" value="XM_066758006.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990367"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="379" mass="42236" checksum="321D8AC6257EB421" modified="2025-10-08" version="1">MPDYSRLTSTPPQSDVLSGYKPSSLQALPSANQTPPRTPSCPCLFASLPFPFFSLFFLLQERCMNITAVRRLSSTLSHLSRNIPKMAYQTRIIGAANTLEHRVYIEQEGKVVSPFHDIPLFADESKTILNMVVEVPRWTNAKMEISKEESFNPIKQDIKKGKLRYVRNCFPHHGYIWNYGAFPQTWEDPNVKHAETGANGDNDPLDVCEIGEAVGYVGQVKQVKVLGIMALLDEGETDWKVLVVDVNDPLAPRLNDVEDVERHLPGLIRATNEWFRIYKIPDGKPENVFAFSGEAKSKKYAVEIIHECHEAWRKLVHGETAANTDAYNLAITNTTVKGSRGCVSTNDAAYVAIPADSRKPAAPIDPSIDKSFFISSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTL7</accession>
    <name>A0ABR3BTL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102467</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614481.1">
        <property type="nucleotide sequence ID" value="XM_066757012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989324"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="57"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="488" mass="52772" checksum="C693B70205D3C75C" modified="2025-10-08" version="1">MPLPLSSRSPKYTTLTTSHVSHIRKLVSAPSSVLSTLDGSATPDELLPYNLDWMGKYLGQSHVLVKPKTVKEVSQIVKWCNENDVAVVPQGGNTGLVGGSTPIHDELILSLSSLNSIRSFDPVFGVLTAEAGLILEQADSFLASKGFVFPLDLGAKGSCQIGGNVATNAGGLRLLRYGSLRGSVLGLEVVLPDGRIWDGLSGLRKNNTGYDLKQLFIGSEGSIGIITAVSILCPRRSLSTNVALFSLPSYAACLEVFSQAKQHLGEIMSAFEMFDNIAYEAVKKHGGAKKVFEKEGSFYCLIETGGSSAEHDSEKLTSLFNTLLSSSLILDGVLAQDNAQVHSLWQIRELCPESLSKAGTAYKYDLSVPVEKMYEVVERMRAHLKERGLLGGKVKYVAGFGHLGDGNLHLNVVAEGNVFSKEIQGVIEPFVYELVADYNGSISAEHGLGSMKAPFISYSQADTSIDLMRRLKRLFDPKGIMNPHKFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTU5</accession>
    <name>A0ABR3BTU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614542.1">
        <property type="nucleotide sequence ID" value="XM_066757073.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989385"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="481"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="572" mass="63897" checksum="6D360B285892439B" modified="2025-10-08" version="1">MDKEPVQRPSTTSASTKRRALASPQTEDGDVPRKRQRLDVPEFLHHVPKPDIQQSLLMVINFINDKLESQERRFNHKLAEQETRWQTRFENLESKWIGKLALAELEVERSKTKVMSIEMDLRERVGRLEGALAVLLRQSQGMPMPTPMGNLSSTDYHAGGDNPGPLVATRGDLEQTLMPIWSREQAIDDLYEQEVVKIQRPDSVVGDQIVVERQGTSLSMGADDEGDTTLSEIQHHHANSYFHNPEDDPILPTVSPQALIPANFTMDAQLDSDDHPDHLDHLEIDGGEHDTNDLWLSGHSLSSMSSPADHPLVASSTAAEHGTTTTTTVSTPLAVDIALAPASHTSSSSSSSSPEYYSIQGEASDTSSSSAAAATLLPASDGSRRTKGRWPPKRAYSLVGTMQEISCDWCHGRCHWCCAGLKETSDMSDKSWLCFDCRHLVKYQGLTKQTVEPCQEDRCIRSNCILLDDIHPQDFIEEQVFVVERLLGRRSMMRKGKRIESETQYLVKWDGYGVHECSWEYRANLKPHDTKLVKDFEAALSREGLVSRNTVILLDEATSHWDPTTGNPLVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTX4</accession>
    <name>A0ABR3BTX4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA binding protein Ncp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614579.1">
        <property type="nucleotide sequence ID" value="XM_066757110.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989422"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="658"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="78596" checksum="567372EEF4BE0A8F" modified="2025-10-08" version="1">MTSDGSNWVVPHRDWSCTPITASEAVQLGLVGLLTRPVIKAVFPSERAISTSHQEQSRDKSIQAAETSPVSTGATSELSDTQWSPTTPGPPVLQPVVTLPQDESAPSRSIQEKAEDSTQLLLFPEPTLRGDLASTNPDPVAIPTTAKETQIPEQPMDRFSGDSLDASTQQQSNIGLSTPQPVVPEFEPTTMAIAPANSEHDTLLANRAADLNLNNRPASRNTRRSSRANGIKAGAGKGVWDLEDGENSGGKGVSDYAGRDGDRASMNRGENGNNPGLGSVLDADPKNFRDEAYGDNERPNMNLRPSRSYIKPVPIVTTYDPQLPDGGSIKRRSVAGSAQSPSYKRPSSRAASIDNEPLQKSMNPRRESKTGSVRSNAYVADYHPNGYENQAPRPPSRTASARNRQFNEAGAAGVGAAVGGLAVGEVVSQQRQRELQGGNSRRNSGVALQDSGAVPRATTTFEEPSDNQQGPGARAVSPRPQSAFGHRPQPQLLAINEGQGEYQQQDGRDSRAGVLGRNGTVISRANTLGRNGTLSRGANGGTIGSRKGAFGRGAGASIGTQPEEVLGRDDIHTRAELSERILDDATLHRLSTMEKKDARRLTKIIKKEAKTEAQAVQTSIKELERLCTLQKEAAAAERKSQLRLTKWTTKEHKARMRFLKEKERYERIEGELRNAENDFEERRDHAAGLTAQVAEKTQDLDDLRAQKAADDREREVKILALKNPAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTZ9</accession>
    <name>A0ABR3BTZ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103562</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613458.1">
        <property type="nucleotide sequence ID" value="XM_066758056.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990418"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="425"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="484" mass="49558" checksum="E2FE7DA278796634" modified="2025-10-08" version="1">MLQRPVRGLPSAMKKSYAGRTQEAAMIISDRRSVQILPIPHSLIAGVQSAFEISLLPFINTRHPLSLIPQDVGAGANTIDNSDTMADLGLTDSLTSSTSSSTRVATSSLSSSARTTSTTSTTSSAAQDLATSVTSSRTSSSSSSSSSSARTSSHTTTSTRTSTSSSSSATSTSTTPSRLTRTSRTSTHSSTSSSTHTSSSATSSIVTSTTASSTSSSATATSTVAAANVNGSGSSSSLSGGAIAGIVIGSIAGIVLIALLITAGIRKKSRAERAKRRSSVFDWGTTADMDNMETYEKPRYDPPSESFAMAEANNNPQHVSYATNDFAVAPPSAERTEPLSYAERHNPQYSYRNSFQPVSLVPDLPPAQPPAQAPAQAQGSFAAQPHQQNVVGAGGAAGAAGVGAAAGAVAGSGAAAAAAGPRGVTAGTWVSVKVGFVRSLEDELPINPGQKLYLHEVYDDGWSLCEDEEHKKGVVPVNCLQSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU44</accession>
    <name>A0ABR3BU44_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614536.1">
        <property type="nucleotide sequence ID" value="XM_066757067.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989379"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="223" mass="23477" checksum="6BDF22F459456412" modified="2025-10-08" version="1">MAEGIELKPLGASAPPPPPRHPDTAPGSLGKAYRSAEEKAKAMIHLQQDAGLDAISVWALVLSSWFAILAIPLLLFPRILIFFSQTPPPIVPFSSSSAANAAAAARENHYDTLTPLEYTLCLSLSLGLIAMSLVSLFILVPTYTPPAANPSRTPLLGILVGLTTVSGAVLWNAGGLGGLGVFVGGGNVFVAIWGWWVIVFGGGRGKITKKQHKHNTPEGLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUD1</accession>
    <name>A0ABR3BUD1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614470.1">
        <property type="nucleotide sequence ID" value="XM_066757001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989313"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="49"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="247"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="690" mass="77545" checksum="82E720C8BC65F472" modified="2025-10-08" version="1">MPPLQFWKPGTAGPEKDGSLPVNTSQNAHLSLDAQRQRLPIYKHREKLLWCVEKYPVVIVIGQTGSGKSTQLPQYLHEAGWTGRNHVVACTQPRRVAATSVATRVAEEVGSVLGDEVGYTIRFEDLSHPTRTKIKYMTDGMLFRETMMDPLLSKYSVIMIDEAHERGAYTDLLLGLLKKIMRKRPELRVIISSATIDAEDFLEYFNTNADGTDRSKDDAIIVSLEGRMFPVEVCYLKEPCADYTQAAIQTVFDIHLKEPLGDILVFLTGREEIDQVIQEVSDRLLSLPKAAPKLLALPLYATLPPEEQSLIFDPPPRDTRKVIFSTNIAEASVTIDGIKYVVDSGFVKIKTYNPRTCMDVLTTTPCSLASANQRAGRAGRTSAGKCFRLYPASILPTTNLASPMPLTTPPELVRSDISLYLLQLKALGIDNLAKFDFMSPPPSEMMIRALEFLFCLKAIDDEGRLTRPMGERMAEVPLDPMMAAILLNSHEFRCGEEILTIAAMTSVQNVFITAEGGTKATMAELERRKFTAEEGDHLTLLNAYNAFARYGQNNKQWCGNHRLNYKALSRAMSIRKQLKKYMDRFRIPIVSCEGDAVRLRKCLVSGYFKNAAKMLPDGTYRSARENAPLHVHPSSVMFTRQPSTGWVIYHEVVETTKSFMRDLTVIDEDWLVELAPHFYRFKGAGLKQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUR5</accession>
    <name>A0ABR3BUR5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614791.1">
        <property type="nucleotide sequence ID" value="XM_066757322.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989643"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="244" mass="26295" checksum="FBA7442C97777A64" modified="2025-10-08" version="1">MTQSPFSAFGYQTAMPSGSSFKPKRKRMSWGAEEEENGAKHMRMRSPTFNHAGYPLPELVADHSNNASDDDQVMDMDQDMPDSSSAIGPPSPAEGYAQDSYSYGAGGSGGFGFGPGAEEDEFEMDMMDDMGTIQMKNYPSLTPHPNPHHFSNPGNDTNLRGTSPLAAQPFSTTLPAPPARGIFQPTVSGPLTPGASDIEKARSQHGPWCQSIPKLIMSEYPDASGRRSMWTVCSDCGACEKTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV52</accession>
    <name>A0ABR3BV52_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103276</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614160.1">
        <property type="nucleotide sequence ID" value="XM_066757776.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990132"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0249973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="613" mass="69235" checksum="EACD09D10FEEB9EE" modified="2025-10-08" version="1">MSQIQNDFLSPSSPDSAPRTVAGTVDTRPQRSRDGCLTCRSRKVKCGEQRPICDRCRIKSRECVWPSEDEAERRRNKKRKAPGARAPYGSSYYGSIYSDHDEASPVHLPAVSVPVQMRRPPKHTIKGTVHVPPNFLPPEAMTGQQGNGKGKQKSKDEKRDEFVDWLVPEKLRAEMMMEPTFLQPYFRTVDERLVMRHYLSKTVHIIIAFESDHRPWNPWLSIHAPLAFQHLPGTKPAADALRTAILAVGGVHLQYSNSPDDRGAAYRITKSAKVQVLKLVKEALQFPDGRPRQLAKEDIELILASLLSCTIASSLAADDSWHHLLSSVLSLVDQLGGAHHILRDAPRDRLSPYRFFMEQLAIRDVFGCMTTELAPSILQDAFTPWFFEAESWSRTDVEWESVERMFGISRGMVDMIARVCTLIAAVRTRGRPIFMDPDDSPSLLPTNPNSSAPPDDLTGLQLAAQNLIAEIRVWDEAENFTPLHPRTQYGNLAYRHAIKIRMLRKVYDVPSDDERVASSAESIIELAAEMLALYGKITWLTWPIVIAGFEIPRGHPSRRTALEMLGAFGPHACFDNRAGARILSDYWMWHDMDGDHATSWEMANMLNQRPFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVE1</accession>
    <name>A0ABR3BVE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">I308_101732</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615063.1">
        <property type="nucleotide sequence ID" value="XM_066756286.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988590"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="142"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="339" mass="37808" checksum="D03BE521EAA55271" modified="2025-10-08" version="1">MGKPNKERNQRSAAPRGRGRGRGGFSAARAGGSGRQKALRSGLSGGAREGMDDEEVFRRVMAGESLDTDESNSEESDSGSGSGSDKDSEEDEESSEEEPATIDVPVAMWDFDHCDPKRCSGKKLARHGLINAMRVGQRFRGIVLTPKGKKVISPEDDEIVQMSGLAVVECSWARLDEVPFNKIKSPYERLLPFLIASNPVNYGKPWRLNCVEALAAGFYITGHADWAEVLLSKFAWGHSFYKLNSHLIERYRTCKDADEVKAMQESIQREMEEERVERRRQRDADEGADLLRENPNHQGSEWQAEEDGESDEERDDVEALIAGLEQANLDDEKAETEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVG3</accession>
    <name>A0ABR3BVG3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Biotin-[acetyl-CoA-carboxylase] ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615078.1">
        <property type="nucleotide sequence ID" value="XM_066756301.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988605"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03144">
        <property type="entry name" value="GATase1_ScBLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="4">
        <location>
            <begin position="447"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="718"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="739"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="785" mass="85409" checksum="CF1D35A24FCE4417" modified="2025-10-08" version="1">MPGPAPSAHQVLVYSGPGVSPLSLSHTLLTLRLLLLPHYTVQPAAPDLLADQPWEPSCALLVVPGGRDIPYVDELTDKRHVTHRIREYVEHGGRFLGICAGAYFASAEVRFDVGGGMEVTGKRDLAFFPGPSRGPVFQGFQYASESGSRAVILNLHESSKLTTLNHIYYNGGGHFVFPSPPPSNVQVLARFQETSSDPSEQLIAAVFTQTGKGRTILSSVHPEYPLSDPPASNAIAKLDVRPSQVEIEMSDKARLSWVEELLIKLGLTPPERLTAADRAKSSVDSEEDPALLLHPTHPSTIFLLSHPKLPQLPEAAVNKPELKGKMKQEDGWNVLRDANDEIRFGTTEATSPERAASEDGITQWLAEARRTRPVFPPSIEDLSLQSDSTPQPPSPPNFHSLTKTILLPSPSVEYSSRWTPLFNFSTYWDELDQARKRSGKRSGVMRQGSDGQGERCSLGDLVLYGETVTSTQTMLDNNPLLLANLSTPLVFLASFQLSGRGRGSNMWLSPPGCLQFSLLLDLPASLSSKMVFIQYIMALAVCEAVDEDGRLGVRIKWPNDIYAEVEGVGGTEIGSGKKGKVKLGGILVNTSYVGGKWRIVVGCGINVLNALPTSSISQLHSLLAAKLSSTSSNKPLPPAPTMEGTFARIMSSFDAKWEQFIEEKGFKGFMDEYHGRWLHSGQDVLLTTTEPHTRVRILSITPDHGLLRCIPISDKPKTSTGLTPLYNRDVDAGEDDRGSWSSPSPSSAPRSTAAGAQAQNQSPFVDLQPDGNSFDLMSGLIKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVG4</accession>
    <name>A0ABR3BVG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614845.1">
        <property type="nucleotide sequence ID" value="XM_066757376.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989697"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="153"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="435" mass="45416" checksum="A56ED863DDC55C6C" modified="2025-10-08" version="1">MSHLLPPNLLKLFAPRPQPPFLKPLTRDERIRGPNNLGGVAGLARRIKEEAEDAEVKQGMDLNPEKALDEQKEENVKTELKQDGEDGEVAEDSGKDRKKKTARDKIAEMGIIGEEAVKMRKELRKKRQEEYKKSAEANYKPQDDAQAIGDPYKTLFISRLSKKANETDLRREFEMYGPIERIRIVRNRKGKSNGYAFIVYERERDMKAAYKDAEGIPIHHKKILVDVERGRTVKGWKPQRLGGGLGGRPKPVVPEAAPAPYVAPSNFRGGRGGFRGGGRGGGGGGGFRGGFQGGRGGFGGGNRGGFGGGDDRGGFGGRGGFRGGFQNRGDRGPGGFGQQGGFGGPGGPGAPGGYGGQGGGYGGGGGGGGGSFGGPGQQNGYQGGQGGGGFGGGGGYKRDYDNAGGPGGYGGSGGGGGFGGGSGGYQDRDPKRMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVI6</accession>
    <name>A0ABR3BVI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribosomal RNA-processing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614893.1">
        <property type="nucleotide sequence ID" value="XM_066757424.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989745"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="6">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="8">
        <location>
            <begin position="99"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="193"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36013" checksum="CDA1CB1DA404941B" modified="2025-10-08" version="1">MFSIKAVAPSISQAFTENVPSTHCKHQAELDAIDLDEDEFGGAGPSKRSIVSPGEIITSSKEYMRGHGTYVEESNVVSSVAGTIERVNKLISVRPLHSRYTPEVGDLVIGRIVEVGAQRWRVDANGRQDAVLMLSSVNLPGGVQRRKIESDALKMREFLAEGDLLVAEVQAFFGDGAMSLHTRSLKYGKLRNGFLLTVPPQLIRRLKSHFYHVPPPCGPKGVDVILGLNGYVWVSNGTSQGRREGGEGFDSEGVYSNQNDEISPEGREAVSLIANIIKALAGEGIPLTETLIGESYAWAEKNVPSESGPFDSETEKKMLNEIVGLEFPEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVQ2</accession>
    <name>A0ABR3BVQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615203.1">
        <property type="nucleotide sequence ID" value="XM_066756426.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988733"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0252483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="53944" checksum="B5233E80B4F2642B" modified="2025-10-08" version="1">MDPFISQFISHVDQCFATRSADNIVSSLPLDETHPFYGPLGQALALSNPVDLFSSNIQPRLTTFPGELKENLSTLISALLRNIRGETDDHEVDQEERAYRKFNRLQQIYSEANKIFGLPDTESSASYAFLNPFIKSLSQKVRQSSDAAASLSTYPLRHPKSARSIRDATRQLIERSMQIASVPMSEVEWNNARDQQHAVGDIIWPLANELFRIYAQRKLHTQSTELQKSLHNLIPPEDERLASRQRSIGVTDVCQSYYWRGKLGVVLLDMRGAAFWLQKAWATCPQDTSGKKQRRSIIIRLIPVNVLLGRLPSPKMLETYDLPQFRLLIDSFRTGNIALWRHVLEEHREWFRRRSIWLILYERGEILLWRNLFRQALKLYYRADPMANKGRCPTWIFIAAASQAFAGSGEIEDSTIGIEDIIVIVSSLIDQGLILGYLSYSHKQLVMKPSQDGMGGFPKIAQVLPRRIESTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVR3</accession>
    <name>A0ABR3BVR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615196.1">
        <property type="nucleotide sequence ID" value="XM_066756419.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988726"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="76"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="525" mass="58880" checksum="7EA10D04F15B03F1" modified="2025-10-08" version="1">MEKNSLDNGASAALSYEQQLKETGQSEFHESVGEAQAPSPTALKVAELHDDGLCPGTEKRRRIEKRLKLKLDLRFSILIVIYSLHLCDYCSNYIDRNNAAAARLKGFEEDLNLTGQRFPTILSILYVGYILFQVPSNMLLNHIGRPSIYIPIAMLIWGMISVLTGVCHNYVGVLLTRLFLGVVEAAFLPGALFILSKWYRKDEISLRYTLLYCGNLISNAFGSLIAAGVLANMDGKLGHAAWRWLFYIEGALTMFFALIAMLMLPDFPHNTKRGFTEEELQVAQLRMLEDVGEIDQDSKDEKWHTGLIMAVTDWKIYILMGSLTTCVTGLSFNIYFPTLTKTLGYGTTETLLLAAPPWIFSCLLALANSTHSDRTKEKFWHSTWPLLMGIVGFIISIAVPPEKKAGRYVALFLQAGSYAGYIIMYTWMSSSFPRPPAKRAVALAFMNAMSQVGNIVGSYIWPTKFGPSYANSYGIVLSMFGATILLNIWFRFILIRANKRLEEAALESTTVQDAMLMQKGFRYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVW8</accession>
    <name>A0ABR3BVW8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cystinosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614769.1">
        <property type="nucleotide sequence ID" value="XM_066757300.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989621"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29768" checksum="791BB406D66ECA15" modified="2025-10-08" version="1">MQPHPLTAFLVNLTGIVYFAAWSYSFYPQLILNFKRKTHNGHLPQVSASDLAFSLHALIISTITLAQVFWYGYFRQLLRRQNSSGQNSDGTLRDETLPLISDSVGNSAARDERGSSTWRELATSHSPIRPSPVAQLFLGGLVISSFVYATFIWAGKAQFLDWLYFVGNIKVVISAVKYIPQVVLNHRMRAVNGFAIGVIFCDMIGSIFSFSQLVISSVFIDHDPSGIIANPAKLGLAGLSFTFDIIFIVQKYWLYRTKMEDEERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVX9</accession>
    <name>A0ABR3BVX9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614178.1">
        <property type="nucleotide sequence ID" value="XM_066757794.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990150"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0249991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="593" mass="65821" checksum="7ABB7E216B1E8EA6" modified="2025-10-08" version="1">MEDLTSISRSLREILNSSTEEQGTLTEVIQKYLESDDTGAQRAACEAIFELLEEGDEETRAQRRTLLLEDSALTYISLIIPLSSTAPGTVHRLIQLISTYARPREILMGLSESLQYVIDRAEGFTVSDDEGNGQPMDDGDIDYESLWAEWQMIISGLVIAIPRLPNVRSTPTLLSLSEEISQSIRSLGPHASTLWSRTCLVMLCSLVDNTWDWTQRTTDKGGEQASLLSGILFEALVLLGDKVDACLTERWFLQTFPKYGNGPHVSKLPEEHEGKWLGGAVVYKRVLDIAEKLCPTPSLIERIIYSPNRSAHGTFAAFNILAATIPLGTIDSHLPDPLPQSLLEDIMPVMCAALSGTSIDAGAVWLWWIANRALETKKEGAQVVNIGYDEVTMLIELLVPLTAQHPGPVMRLALFKLIGTLISLLPSRDKVLALRHLLEPENPFDAVRIESMSILREETASNNDLLSPELLAQLAPILFPPATLSDPDSPFNLSSSDLLSSPNPSWWTEVANYIWFLSTRDNTNRSGVRSTYREGLIVWLEAVRLKLNETVRYIQEENGNVKDVAEVLPGCGVEFFLNRWGDALDRARAVLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW04</accession>
    <name>A0ABR3BW04_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615287.1">
        <property type="nucleotide sequence ID" value="XM_066756510.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988817"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="170" mass="18487" checksum="F97AA1A093D35449" modified="2025-10-08" version="1">MSSTLFKSSSSVLPTTIVTRIRTKTSRASAPSLWLSRAHLKSQPVVPPPIPPTYPMRVILSDGSSFTAYTTAPTPSTKKLTRDVNNNPLWSPASEKKGLGEGEEGRVTRFRKRFEGLGGDIIGGIGIEGDTKGDAFALEDLDWMSEGAQEEKISDRQRNPVKSKGKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW28</accession>
    <name>A0ABR3BW28_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615310.1">
        <property type="nucleotide sequence ID" value="XM_066756533.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988840"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="438" mass="47498" checksum="5A57C6472E2B2D8E" modified="2025-10-08" version="1">MAHSPRPTPAPNRHALFHKRQSYVTVSVIANDTDTSTSTDASSHSPFPVAIAIPALVGGMAAAIAAFGFWLWWSKRSKRLKRERWEAAQRRKHKRLAAEKDKQTHSPSAGQSQQKSPTGEKALNPIPPPLSTAQPYYPPPQTNEYGYAPSRQGYSSWQTQPGIEQVQYGRQASHPQQGYYNPPTYAQGSSPQLSREYSSESTIPLAQNITPPAASPTSPTSSHNSNNGSGNGSQSNGNVPPPRSSDEEKSSTSSSSSPSKKSSKNSRAIARMAVAESAAANASLDRMFRHKPSKPSPLAIKAQQERDAQNAKGGGDPLTRISSDETANPFNTESEGLYATSGEWGVALGSPDEEDTFADSQAAVLDGSDHREKSNYSEDPYLRKKAQTTSGLYSQDPYALYHGEEEDEEDADRYHNAAESMGLGTASKNKKRYVGKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW32</accession>
    <name>A0ABR3BW32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615222.1">
        <property type="nucleotide sequence ID" value="XM_066756445.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988752"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="228"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="731"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="731"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="836" mass="92113" checksum="1C0991E6B3069762" modified="2025-10-08" version="1">MVNSPPQALPPIKLKLSLSNIHQPSTPTPTHNKKGKHTALPTNPSDAHSSTPLPRPKLKLNAAASSSFRINLPAAGSSTADLSTVATPITSTAASPADPITPSGSASKVQTSPGKKSSVKKSAKPSASKKKSGPKRPSAIPQRLLSSTSTTPSKPSTAIPETPTQVKDEPEDLSPASSSIPPAEITNLSTPSQQDGDENSGTGKRPVKWMRVKKPLKELLQKIMVEIRKKDDYALFEEPVDLEAFPDYLDVVGGEDNMMDMGTMQAKVDRDEYRNIDQIEGDLRTLASAAQKFNPPGSIPHKSAGIILAHGLKHIERSRPLVLTPPSTPRDSATPARATSVLSTRELTAALEDRKARDDVPPNLYIPEEMLSFPPNSAMARAVGWNLNGGKRMYNKRISRAREKFGGKWRNWTTDGSRDIAEADDIHVLFDPWRVRTGEEWKKVPDWQALRNEANWWELEMPPPPPQSAAQQAPLPFNPGEPRLDKVPLHEFVPYDFGQYPSISSEISFLRQRIPNVSEEEDILSEHIRPVYPRLKKGESAPPPNLINIYDGPLRRTAGDWMREMATGGVIGEAYIDSLNRFVKGAMKEGAEKDLSGKEEQDSKPRLGRNSDQLSLDEYVMTSYHAPLLQTVTRQTIHKTLGHLSSAPSRPDVILPMAKAAYARVALRFLTSPSNPMDIKPLLREEGDFMYQGVGGKSGVNVGLEWTGGELSRLVEKMRVQKEYLTGKRKREEGNQVEGETKRIKAEEAEETDSTVITDKPSLVSELVTIPHTTQPRDDAALSGEPEKISDEELKRLRLELVALSKFYPLPALKKMSKEEAAKLLPVNVRGLMCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW38</accession>
    <name>A0ABR3BW38_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase</fullName>
            <ecNumber evidence="9">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_103356</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="9"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614238.1">
        <property type="nucleotide sequence ID" value="XM_066757854.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990212"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="429" mass="49379" checksum="C8217DE088424F29" modified="2025-10-08" version="1">MPVPVNEKQMVEYDASSPQVMQLFYRRLFPYRPLYLWLNQEQIPSKLFTHREFAFTLAGDVYLRYQSFNNVDEFKVSIARHIPSRFEIGPQYSARPKDRKTLASGALQAQRRELVFDIDMTDYDEIRTCCTDKTICKRCWGFIAAAVKVLDHSLRETFGFKHLLWVYSGRRGIHCWISDQTALDLTDDQRRALVTFLEVIKGGKEQSKKVNVRGPTGDAPLHPFLSEALETLKPLFSSLCIYDQDCFKEEKGWEALLAILPTDRAVIGPLRAKWEKNPDSSSDDKWRELMSEIAKHKKEEAIMNKFTKAVEDVVLQYTYPRIDAEVSKHRNHLLKSPFCVHPGTGRVCVPINPSLIDEFDPDTVPTVGQLLNELDNVKSEDPDAAGRRMEDYEHTSLGPYVEMFEKHVAAILRDSRNAKRAVKAETLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW97</accession>
    <name>A0ABR3BW97_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatase activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615297.1">
        <property type="nucleotide sequence ID" value="XM_066756520.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988827"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF16">
        <property type="entry name" value="GROWTH REGULATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0252577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37095" checksum="48C5B6454D71DFC9" modified="2025-10-08" version="1">MAIPASSNPITSVAPNSNPITSVSPNNYGAAPLYPSPTNPQLLSRLNLDLRGTIFPVEREMLMLLPESVLLGLFPQGLILSKPASWEGGDDGIFTVDFDPECFRYIIDFWSKAQDSFYGSPTTSGLYHAQQRIPTVDALSDHSQNPLLSKQAIIVLREELEYFSITKPGAAARTDITTGLANEDLRVLKRNCGKALEEKKAIFAALERNVNNSANLAERHLIDMLCVSGFNRDDEWGYRACEPQRNVISSMALVLLKTGINHQEDNKEGSPEIDPVQMGTAQKLLLFWRKPARKCWWDSVEIHVPSSLDAKSDETISVKVWARRVWTLELSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWC7</accession>
    <name>A0ABR3BWC7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615400.1">
        <property type="nucleotide sequence ID" value="XM_066756623.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988930"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="23"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="177" mass="19945" checksum="52D6D66BDB676D7E" modified="2025-10-08" version="1">MSQWAQDMPFRWGESRDGWKTKWRQSCFCGKVAFVYDSDPLQVKACHCGNCQKLHGAPYQQAAIFPKSSVRLDTPPDHVRFLTASSDFHSLSSSPTPLPRKISCGSCGCPFMDEGRNMIMAFPPLFEFHRGDGEAGVPEPLRVQSHIFYGHRIVDVVDGKDKWEGHKGESKKMGDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWD2</accession>
    <name>A0ABR3BWD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615418.1">
        <property type="nucleotide sequence ID" value="XM_066756641.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988948"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="43442" checksum="CEC7B1FF10DBA530" modified="2025-10-08" version="1">MSEAGSASTPQSNTTKDRHEPRGRKPNDHLPPSRAREVQRAFRLRRAEHLASLEERILQLETENSQLRALLSLPAADRPKIGSGPTGRGKSLKEGGVPMSERVRARKEARERERRALGLPEADTTDMSESERNGRDSETLSPRATSGAGPSNTTSTTHTSQQQPSVPQLSNPQNVPALFNSAHEVSPAPFNYQLPMPFNLPVSPDTHFADFTNNLDNSLYKSNTASATPNFSGMFSMFTSADSTGDSSANGTGVNKPSPISPPLTNPPAASPSQLDLLTRLKSCCHVSDSHVVNDPGLLVFATRLCQSFGCSFGGTHTEANPRSDAENLTLEDAWRALKATLDPGGDADGENRINTGKMAAELVVRAAHSRGAGGWITCRYREGLSIRRNMVQALVQGLGGKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWU4</accession>
    <name>A0ABR3BWU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615477.1">
        <property type="nucleotide sequence ID" value="XM_066756700.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989007"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046032086" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="77"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="261"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="848" mass="89246" checksum="DC76F7F71B0EC5A4" modified="2025-10-08" version="1">MAPIIETAITLLAIAGSVAEAKPLRTPGRHAPPGVADVLASSKRSLHSLLARYYGTAHGLSKPPSLPTKRDTSLPEGWSTFGCVAESYGERLLQGFAFSSSSLTPLLCVTECAKLGYTMAGTEYGDECYCGHSFEGNGGGMAPSSVCNMPCEGDTSEVCGTSWYLNLYTYNSSALPLCTGTSSTVSVAVEETSSLLSTYYSYSESSVTVTTTVSSGAIETAGSVTDNVSGDAASATASTTSSAATSASTYPIHEDSDGSSDWYALGCGLDSEDRLLSSYFIRLDSMTVDSCLTICEDRGYMYGGLEYSDECYCGNSLPSSTSYDNNRCDMSCAGDSEDTCGGTWAIELFKLISSPSSTYADSMSTDSATTTLVTSTDTASATSIASIINSPSAVTATSGYASEAATVTESTTMSASVIAPTSTTSTESTASAASTSVPSSSSTHQVWAHYMVGNTYPYTASNWASDISAALTAGIDGFALNMGSDYWQPARVADAYSVAASTGFKLFLSLDMTVLSCSSSSDAASLVSIVQKYASATAQATHEGKVLVSTFAGSDCAFSWQTDFVDALSSAGIDIFFIPSIFSDITTFSSNTWMDGELNWNSGWPMGTNDITVASDDAYMAALGSKEYMPAVSPFFYTHFGASSWNKNWLYRSDDWLYCTRWEDIIAMRDSVKMTEILTWNDYGESSYIGPIDGALPAGSETFVDGFTHTALYSLTYYYATAFKTGAYPAITADEIIMWARPHPHDATASSDSIGKPTGWSYTDDYLYAVAMTTDAATVTLTSGSTTETFSVSAGLTKVKIPLSAGSISGSISRSGNTVASYDAGSAFTYTTSPITYNFNYFVGSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX43</accession>
    <name>A0ABR3BX43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF833-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615676.1">
        <property type="nucleotide sequence ID" value="XM_066756899.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989207"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0252956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36918" checksum="C9494E7B4D38A996" modified="2025-10-08" version="1">MCVTFFTLSQPGYKLILAFNRDEFLDRPTLPAHWHNFDSSPNLTPKLHKPNTFTDSCPREKKGNDEGARVLSGLDRGKAEGGTWLGISKDLKVALLTNIACIRPASGVQPLSPPPSRGKLLREFLSPSLSTSSQLETQSYISSHFLTAGDYEGFNLLLFSLSPERSIGYLTNRPAPSTLDLTSSLCGGTDGQRKCVGLSNSPLDDKWPKVQQGEKNMEKSLREWEEKREGEDRLVERMFGVLSPSRPVTCEHDLTMSTTIPPVKLGEDLFLNTDPHCTRARWKGTRTATVIIVMDSGETTYVERDIWVIGQDGEPKKGEAERRFKFVGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ17</accession>
    <name>A0ABR3BZ17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615852.1">
        <property type="nucleotide sequence ID" value="XM_066755566.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987864"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="108"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="353"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0253631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="812" mass="89871" checksum="C1A4E8ED50B9C934" modified="2025-10-08" version="1">MAVDASTSSRPPNSAKPQPRVSNFNDSSDDDEAESTPKTEKKKKKKVKDLDVNGVNSPKSPKKRKIGGANGDLGEAKKDGAEARRREAERLLEKRKELPFYQGRRMILEEIMANDTTIILGETGCGKSTQLPQLLRTHPISLNHFSTSSSDRFRKPSIAITQPRRLPAIALANRVSQEMGCQIGGEVGYSVRFEDVTSRETRVRYLTEGVLMRELAGSDPNFPPPKEGPNDLTNGEREDDSHSSEGQGLNLLLNYDIVIIDEAHERTLNTDFLCGALKRVQRIRKDIVRRQAEGESQGEEKITGKKKVKELKLVIMSATLDPTKFKTFFGTGRDALLVKGRMYEVATQHVLEPVDDFIEAAARQVMTIHCSPDSPGDILVFMPGSEEIENCVELLKRVSKQLAPGSSALQVLPLYAALPPTAQSKIFVPTPPNTRRIIVATNIAETSMTIPGVAFVIDSGFKKEKEYVFRNAGALEHLRKKGISKASAWQRTGRAGRERAGHCYRLFTQDFFNRMPEFDAPEIQRCNLSSAVLQLIAMGQNPFDFEYIDNPGRDSILAAFQELVGLSALSSPTIITPLGLQMLRFPLDPPHARILLAAFEYGCPNEIIDIISLVNAGGNVFIDRPNDREEAAQARQKFIHREGDHLTMMNVFRAYIELKESRASSHSNFSSQSLVGWCKDNHVNSKTLAQALKVRDQLRELSERLGKDWKSSCGGEWGMVGKSLLQGLFMNTAVIQADGSYRQTAGSLTVKIHPSSVLMSKKVPAILYDELTITTAFYARNVSAFEQHWLTEVPCFAKAGTSVAAPVGKGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ29</accession>
    <name>A0ABR3BZ29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615868.1">
        <property type="nucleotide sequence ID" value="XM_066755582.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987880"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="5">
        <location>
            <begin position="126"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="482" mass="53484" checksum="30130A9D2909BDFB" modified="2025-10-08" version="1">MSPSSTENAPTNLEELKELLKNDNKVKVAGVDVDGVLRGKIMSKSKLLSAVKSEGFNFCSVIFGWDIHDQGYNKELLVANWDNGYRDLFAVIDLSTFRRLKWEKDIPFFLCKFIIPEKGESLPVDPRSLIEKVTDKGKAMGYKCMSGAEFEYFQFAENAKSLADKNFRNLNPLTTGMHGYSILRPTLNMDYFHDLYDMAVDFGIEVEGHHTETGPGVYETALGYTDASRMADNACLFKLVAKSIGMKHGVSPTFMAKPWGDLPGCSGHIHVSLQDKNGKNIFAVSDKEAASGGRKGAAFKDLKYLSQEGEWFLAGLLEGMPDVVPMFCPTINSYKRLQGGQAMWAPDTATYGYDSRAASVRLLTAPGVPGYATRFEVRVPGADMNPYYAMAAIFALGLRGIEQKRPLPYGPIGSPGVSRDTVKHLPTSLDTATQAFMKKDSLAREAFGDFFVDHYGGTREHEVELHRKAVTDWEVARYFELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZM1</accession>
    <name>A0ABR3BZM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615434.1">
        <property type="nucleotide sequence ID" value="XM_066756657.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988964"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0252714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="221" mass="24812" checksum="F05E7700B91FE5A3" modified="2025-10-08" version="1">MSQSSLDYPEMKELFNRNLKWSEKVWAKDPSFFPHHFPGQRPEILWIGCSDARIPETTILGCQPGDIFVHRNIANLFSPQDDSLNAVLMVALMNFKVKHIVVAGHTNCVGCLTALNVSRLPPSPPTTPLQRYLRPLATLARTLYTPDGPPPLDLLVEENVIQQVKNLVESDIIKDNWKRRGADGAVIHGWVYHLEDGIIRDLNVSVGPPGHVPRKQVNSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C096</accession>
    <name>A0ABR3C096_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616223.1">
        <property type="nucleotide sequence ID" value="XM_066755937.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988239"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0254002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="45894" checksum="B020DA7A5B3F522A" modified="2025-10-08" version="1">MHENSQHPADKSLSNIVDPIRSPSFAIPSEPAPAYSALPSRDSDFFLAPVLEGKVGDIELVTVDGKRFLVHRKLLEQETVFFHIYYGFVPAWRLDSAGSTQLNQPRAVPIELPPNSHRPAQSRERDAMPLSNILCLPKLLAAHLSRSPGAASLLASHQRQNGNDPCDDPSAPLINNEDNPDSPPPVFQDLPPPPPPKDVTAPTPTSSRYTWAVPEPSTVLIAFLSLIYPSGTISASPTSLLTSLQLTGRVVRAALGYQSAKALSTARDHMVHWVDESPVQVYAMASFFKFGDLARLASAKALRVPPPQWPEDARVLMGRTSVSKLMALQSARLTGLNQILSGPIEEDEHAHTCVRFPMARDVWRRMADETCKKVCADSDLIELLDVDLRGVHCGECLVLLGQSVQRCLYEARELRCMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0T3</accession>
    <name>A0ABR3C0T3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NIP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616455.1">
        <property type="nucleotide sequence ID" value="XM_066756169.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988473"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="7">
        <location>
            <begin position="96"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0254234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="181" mass="20616" checksum="87612E54EFFE5F25" modified="2025-10-08" version="1">MRPLTEEETKAVFEKLANYIGKNLVHLIDRDEDDEYCFRLHKDRVYYLPLPMLHLATSVARPNLVSLGTCFGKFSKTGKFKLGITCLDYLAKYAKYKVWIKPSGELPFLYGNHVAKAHLGRITEDTPEHQGVVVYNMSDVPLGFGVTARSTLDTRKLEPTGIIVFHQADVGEFLRDEDTMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1Q3</accession>
    <name>A0ABR3C1Q3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101464</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616306.1">
        <property type="nucleotide sequence ID" value="XM_066756020.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988322"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0254085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="556" mass="61581" checksum="2109305553E72011" modified="2025-10-08" version="1">MDGKPATQYKAWKKLQSLHSSKADKLVLKDLFNADPKRFSNLSKSFSSSSPDVSLLLDYSKNLVDDEVLSTLFDLAREAKVETFRDEMFAGKHINTSEGRAVLHIALRNPPADKGGFKISEAGVDEVQAVLAHMKEFSDSVRSGAWKGYTGKAIDTVVNIGIGGSDLGPVMVCEALKHYSKRDLKTHFVSNIDGTDMAEVLKACNRETTLFIVASKTFTTQETITNAESAKEWFLEQAKDKAHVAKHFVALSTNTKGVTEFGIAESNMFQFWDWVGGRYSLWSAIGLSICLSIGFDNFQELLNGAHEMDKHFKSAKLEENLPVILALIGIWYNDFYGAQTQALLPYDQYLKKFADYFQQGDMESNGKSVTKDGSRVDYETGPIIWGQSGTNGQHAFYQLIHQGTKLIPCDFLAPVETLNPISGGKHHEILLSNFFAQPEALAFGKTEKQVIEELGPEQSKNSALVKSKIFEGNKPTNSIMFQKLTPGTLGALIALYEHKIHVQGAIWGINSYDQMGVELGKVLAKAILKQLGSESDVQGHDSSTTGLIHYYQKHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C2A7</accession>
    <name>A0ABR3C2A7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616117.1">
        <property type="nucleotide sequence ID" value="XM_066755831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988132"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045201625" description="Glucosidase 2 subunit beta" evidence="7">
        <location>
            <begin position="24"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="8">
        <location>
            <begin position="436"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0253896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="557" mass="62372" checksum="D2A6F7058E0A443B" modified="2025-10-08" version="1">MENLTVLVTLLSSLLLFTPVTFAAQEEQKIVVPSQIRGLNPSLYDKYEPSKSGLFHCLDDSKTIPFSAINDDYCDCPDGSDEPGTAACSNGLFWCKNEGHIPGSVRKSRVNDGLCEPECCDGSDEWATGACPNNCEVVGKEWRAAKEASEKIRKTGAKVRGTYIKWAQGEKKRLEEDLAKKRQELVTKEQEVAKAKAILEKTEAHSQEDLERKKKSPVYISLLSHRLALARLRSKTNRLETEIESLHSLLREMAKGYNPNYQDMAVKAAVVGYEELTGIKYREGESEGETELKKEEKEEGDKEEEITEQELEALEKEDLEALLLSDTTDENEEDDEDDGTGLLWKLDEYIPDSLYGSWEHVRDVAIDWMIRFGLAGRSKTKTSSGDGPQVAAAREKHRLLNNELVKLNGAIRDTEDTLKNMELHYGREGEWKKLDGSCVDKVVGDYTYELCFFGKATQRSNKDKSSNNLGSFSQWNTAADQGSLGYYSQQLYKNGAKCWNGPNRSVTVDLSCGTSNALISVSEPEKCEYRFKVTSPALCWPEAPGSPTDEVKVKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C411</accession>
    <name>A0ABR3C411_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616642.1">
        <property type="nucleotide sequence ID" value="XM_066754741.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987026"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="11"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="334" mass="36621" checksum="8BAD1479E909F8EF" modified="2025-10-08" version="1">MKAILIKNGTGHADDLYLGQEPTPEPGNGQVQVKIKNFGLNRMDILQREGKYPLPPQASKTILGVEFSGVVTKLGEGASKWKEGDEVFGLSYGGAYAEYIVSPEIMLLAKPKKLSWVEAASIPEVWMTATQGLTLEAPLKEGQNVLIHAGASGVGIAAIQIALHALGAAKVFTTCGTDEKVESLKQLGHSDRLHVINYKTQNFEEEIRKVTNGVDLIIDFIGTNYFLQNVNILRLDGTLYSLAFMSGAKFPEGASMAPFLGKRLTFKGSTLRSRSPEYQAKLLKTFEEKILPKILDDTMTIKVHEIYPWSRVSEAHKAMEGNKNSGKIVLEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4K0</accession>
    <name>A0ABR3C4K0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616840.1">
        <property type="nucleotide sequence ID" value="XM_066754939.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987226"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="271"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="479" mass="54606" checksum="6364353CF11C47DE" modified="2025-10-08" version="1">MSDDEFMMDDIADDEEYDFDYDDDDNDAEEDAVGDVENQYYKAKALKEDDAQGALKAFRTIVNDQPEKGEWGFKALKQMTKMNYLRLHEPEKALETYRELLSYTKSNVTRNYAEKTINNILDYVGGEGKHAAKAPKVPLDTLEKFYEVTRVACDEAKNERLSTKCNLKLAKLWLDRKEYIRLHPILQSLHATCAPAANSVSSDDQSKGSLLLEVYAMEIQMYSDLKETRKLKAIYNAAVQVRNAIPHPRIMGVIKECGGKMWMQEKAWDKASEDLFESFRQYDESGSAQRIQVLKYLVLNTMLMGSDINPFDSQETKPYKNDPQIVAMTNLVSAYQRRDVQEAERILKANQATITNDPFIDHFVGDLLTSLRTQYIVDIIKPYTRLELDSLADKLNIRRNEVESLVVSLILDDKIKGKIDQVNGILVLDRFGMAQRKRYQALGTMAAELNVLAGKVENEKLGVKDGGARAWVGSQPIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4K7</accession>
    <name>A0ABR3C4K7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616563.1">
        <property type="nucleotide sequence ID" value="XM_066754662.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986941"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="328" mass="36467" checksum="FE95D899E57443B1" modified="2025-10-08" version="1">MSSIEEISKAAVTADLARNLTPLIISLGVDALMMGVIGSQFLRYLSITERESLYIKLFIYLAMAAAVATTCFTWAMEVNMFAYNYGQYTQFTSQLWSAWYGLLCSMTKIPVQAFYGERAWRINNRSLLISATLPFTLSLSAIGSIGFTIVDHKLDFSADISYTGTVFFYLWPTACIVSDLINTGGILWGLYKSRTGWIVTDKLIYKLMRIAVEAQIPPTVFASIVLMAWSQKMSSISTLFMQVSDQDKSCASAETESKGLSFPRSISPELSVFSTLAILYARIAQLITATLTSTPARRVADDKQIPGLQSQQTHMSKVTSHMKLQKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4L2</accession>
    <name>A0ABR3C4L2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_100372</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616844.1">
        <property type="nucleotide sequence ID" value="XM_066754943.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987230"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="9"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0255567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="455" mass="47973" checksum="BF89F65B466F844A" modified="2025-10-08" version="1">MPSNSPYIHILWACISSWYYGFHLSELNFPALSLTCTSPTSSSVIPQCLYLSESLYAFTTAIFTVGGLLGSLSNPWIVSKYGLKGGISLTGWINLFGAGAMTFAPHWVILATGRLVTGVSSGLAISLVPPYLSTIAKSSTELVHRSGQIGTMNQMAIVLGICSAQVAGLLLTGEKGDVPGSWRYVVFISGFISVLQILVSQMISMPSEEHIKPTQPSAFDPESQSCSQGSDEAASPLLPSSQQTVQLTLRQIISSPSLRGPSLLCAAIMALQQLSGINAVMFYSTPVLRPLLPTSVGVVSVGITIVNAIMTLPAIFLMDCLGRKVLILASIVGMATTSILLAIGLNGHHQIMSAISILAFVASFSIGLGPVPFLLTSELVPLPAVAALSSLAVSTNWVTSFLVAVFFLPLRDLLSYPSDPQSPETGREGEGRVFYAFAAILLMGGVMIGKGLKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4R1</accession>
    <name>A0ABR3C4R1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_100410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616882.1">
        <property type="nucleotide sequence ID" value="XM_066754981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987268"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="10">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0255605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="218" mass="24850" checksum="55ABA4E568D49C54" modified="2025-10-08" version="1">MDYQNRAGANKGSGGVAGASETAVDRRERLRKLALETIDLAKDPYILRTHLGTLECRLCLTLHVNEGSYLAHTQGKKHQTNLARRAAKDNKDQALMIQAPTAAQQVKKKVFVKIGRPGYKIIKIREPVSQRMGLLFTVSLPEIKAGERPRRRFMSAFEQRREIPNKAFQYLVLAAEPYETIAFAIPSKEMVDVDEDPESTWEHWDADERVYSCQFLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4R4</accession>
    <name>A0ABR3C4R4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616888.1">
        <property type="nucleotide sequence ID" value="XM_066754987.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987274"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045595867" evidence="1">
        <location>
            <begin position="18"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="181" mass="19562" checksum="3D15C4384A5C5613" modified="2025-10-08" version="1">MKLLSWIMLPLIPFVSASVSTIYWPVSSPSPSNPWVLGAKNLLAWTTGSGTGVQSFDIQLHNSNRSVMVGFLPIALRVPMERLPTGHRNYGGEMEIDLGSDVPTGDGFYLLFMNTYHGEVYAKSKKFSIYASTPSNYTSADLPTATITATLLEAPNPTQQWAITLNGINQDATATATSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4V1</accession>
    <name>A0ABR3C4V1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peroxidase</fullName>
            <ecNumber evidence="13">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_100445</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="13"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616917.1">
        <property type="nucleotide sequence ID" value="XM_066755016.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987303"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 13 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="14">
        <location>
            <begin position="114"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0255640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="377" mass="41933" checksum="B9AD1F09D6BB44C8" modified="2025-10-08" version="1">MSFRAPNLLRSTVGRRAGQALNLRSQVIRRRFATEGGPELGKPSPQRSSNTGYLLAGFGIAAAGAAYYFYSSGATARDSTGKADTAVRGAVATVEAKTGLRRGKDDYQKVYNRIAETLEKEGYDDGSLAPVLIRLAWHSSGTYNKEDGTGGSNYATMRFKPESDHGANNGLNVAREHMEKIKKEFPWISYGDLWTLGGVCAIQESGGPTIPWRPGRIDGYAAQVTPDGRLPDATQAQDHLRFIFNRMGFNDQEIVALSGAHAMGRCHTTRSGFDGPWTFSPVTFSNQYFALLRDEPWQWRKWNGPAQYEDKKTKTLMMLPTDMALVKDKSFKKFVDVYANDEEKFFNDFSKAFSKLIELGVPERQWAGEPWTMATSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5H8</accession>
    <name>A0ABR3C5H8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616878.1">
        <property type="nucleotide sequence ID" value="XM_066754977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987264"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="278"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="607"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="780"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="900" mass="98628" checksum="8F568B977E9DE3BB" modified="2025-10-08" version="1">MITLTPLSASAAETSPSEPICYLLELDDARILLDMGQRDYRASAQQSRWDYEEAVRDLAPTLSLVLLSHSSSNYLSLYPYARARWGLTCPVYATQPTVEMGRVVCLAEAESWRSECPVESEGEVAGDGGSKEPFKGPFVPTVEEIHEAFDWIKAVRYSQPLHLGGDFSHLLLTPFASGHTLGGSLFKIRSPTSGTVLYAVGVNHTSERHLDGMVGVQNGPTGYVDGVLRPDLLIVEGSRSMVINPKRKEREAALIDTITSTLELNHSVLLPVDPSPRLLELMVLLDQHWTFKRTPKVKQQRYNEPPADLWPYPLCIVSKTAQDMVAFARSLIDWMGGVVKDSAGDMVDVGRGKRARGARTALGSEYGVLDFRHVQFFLNPIDLLQTYPLTRPKLVLAIPPTMSHGPSRFLFTAMANTEGNVIMLTGRSEEQTLARDLFNRWERSQTAGSKWGEGKIGHLTQLEGKLQVEMDSKVPLSGAELEAHMESERLQKEKEAAHKAAVDRSRRMLEADDLESDSESESEADGLAGGITVRRTEGANAYAGDGEDVRTMSFDIYVKGQQMRSGRGAEMARFRMFPFVERKGRKIDQFGEGLDIGQWMRKGREIAEEGETEEVREAKKRKEEEEEKAKQAPEPPSKYVSEEVGVELKAMIGFVDMEGLHDGQSIKTIISDLQPRKLIIVRSSKESTQNLISFLGSVTGFTKDIFSPSLTEEIKIGEHVQSYSLTLGDSISSALAKKWSDFEGYEVTFVDGKIVLPAGSTIPILETPSLVGPLIKTEAEGDEVDGESKPSAEELAAASTPPISSSAPLPLPTSTFIGDLRLARLKHRLSLLNPPIPAEFAGEGVLVCGPGISQEAQGAASIVSVRKIGEGKIVLEGCIGRVYVEVRKALYGGLARVDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5J8</accession>
    <name>A0ABR3C5J8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617175.1">
        <property type="nucleotide sequence ID" value="XM_066755274.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987567"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="46831" checksum="F94056F1ABA83B2A" modified="2025-10-08" version="1">MIEEKYIGLALALGGTFLIGSSFIITKKGLNDAAARNPDYSHSHQRQSGSRNASDDLSYLQNPIWWAGMVTMVVGEVANFAAYTFAPAILVTPLGAMSVIIGAILASFLLDEKLGRLGVCGCAACIIGSVIIVLHAPSDKEVETVDEILSYAARPGFLVYITFVAVFSLYMIYRVVPTHGTRNPMVYLSICSLVGSVSVMAIKGFGVAIKLTLSGNNQLTHVSTYVFGVVVVGCIVVQMNYFNKALDTFSTNVVNPIYYVFFTTATIIASAILFSGFNTPGGVNTISLICGFLVIFMGVFLLNTSREPEQIHHPTSLESGLMNPRMSMSGGRISVESNGAGWNYGTVPGSGYAPDGSLNSAGHGRRSNLYRSQNSTLFNAFEEEGVPLGQLPEEDESSGDEVNARRGQQAPGRSLLGKKGREDVAGGRHPAYQDMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5K9</accession>
    <name>A0ABR3C5K9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617031.1">
        <property type="nucleotide sequence ID" value="XM_066755130.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987419"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="7">
        <location>
            <begin position="717"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="465"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="937"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1043"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="947"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="973"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1006"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1068" mass="117165" checksum="7C393BD1F50833EE" modified="2025-10-08" version="1">MDPAIARNLNDKIYDRRKAAALELEKQVLSSDKLKISAIIDQLCAMLSSSSSALHTRNGGLIGLAATAIALGQDVAPYLGQIIPPVLACFQDPESRLRYHACESLYNIAKVSKGEILVHFNEIFDALSKLSSDSEMSVKNGAELLDRLMKDIVAEAAPSYVSIYPDNRNPSFSLGSTARNRSFTMDSKSHDEYQDVRDAKHFEDNRAFSLERFIPLLSERIYVISPFTRMHLVSWLMVLDSIPDLELVAWLPEFLDGLLKYLSDNNVDVRLATENVLAEFLREIKYIAQVQDKQAESERVAKEAREIVESKKREIGAKDGSAFQDDSESEEGEDREEADEEHNWEGEGSGAWVPGQGVLVDHAAIMEIIIHNLSYDDELVQSTAMEWILTFLEFAQNTVVAFTPQIVPAILPNLASSHSQIKMAAYDTNSSLYHVIQSIALQVQHPRSQTEGLFNAAPLVGTNSSHAGSPPLSLTLASAPTKKDPITEVNDSARSPPAAPVSDPLEAATAPPAINSTSAPVSVTGGTVQRGTTSSMLTSGLGHKTRQSATISLHQVSEPATPSSNDAPAISIVNPAKGTKVQPEYASTTAPPVQPFPLTSSLLSPKAPVQQMMEEDQDPFDVKETVNVLTLQFLSDHAETRIAALEWLLMLHLKAPDKILSRDSGTFPALLKTLSDPSEDVVKHDLQLLAQISSSSEESYFTSFMIKVLELFSTDRRLLEQRGSLIIRQLCLHLNAERIFRTIAEILENDDDLEFASMMVVKLNMILITSPELGDFRRRLKNLDSRDGQMLFSSLYRSWCHNAVAAFSLCLLAQAYEHASNLLQIFADLELTVQLLVQIDKLVMLIESPVFTYLRLQLLEPDKYPWLPKCLYGLLMILPQSTAFISLRARLQVVHSSGYVPTNTKTPSTAAFGPTRSKIGKDEIRWQELLSHFRSVQNRHEKARRQLSPTDIGSTQGSIHYPSSFQNYPSNTSVPGPSAVVSSSTKGTTRKKTTTSTSNSKQGSTDIRSGTSPLNPKRGASSSTNGTGLVSLGGAVASMNATQGLGIRPTSPSRKRILGGLRKGGSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5S2</accession>
    <name>A0ABR3C5S2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617249.1">
        <property type="nucleotide sequence ID" value="XM_066755348.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987641"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="115" mass="13153" checksum="0F105D24CE655A21" modified="2025-10-08" version="1">MRRDEAAEKEEQRILEQSEIEMHQETGTETSNACVVHLSSLSPIPVSEVVLGLFRLPNCWEGSEKPQRRGFICNVPIKVLAKGHGILHFLWPRMFEGFRGEERPATQTANTKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5Y2</accession>
    <name>A0ABR3C5Y2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617307.1">
        <property type="nucleotide sequence ID" value="XM_066755406.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987700"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0256030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="29483" checksum="F5D481138804004E" modified="2025-10-08" version="1">MSPALSPLTAQISALLASPLHAALPLPRLPLIHAVRVSILWAALTRHKRRPGTLQHAFGYLVLAWAGNTALALLLSLPPAWLVSPAPWIVYLLVYLLFIPTGLSPYIVDHCPQVLLNTAGAAVDGLSRGVTIASIAGMLEASAKFHAAAHGQAVSAWTYTLLSTVAVSSGGFLVSLLSLHEASYRLSVPSVFRRGAGVWGTMDVWAAALAGLGYWAMVSVRMEDVQAMVGSGFDRWGVKSTAMDGLSARTVCVLFLGGILILRAVRTQLVSTGTKRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6N1</accession>
    <name>A0ABR3C6N1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616703.1">
        <property type="nucleotide sequence ID" value="XM_066754802.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987088"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="494" mass="55391" checksum="243AB51042C4B41C" modified="2025-10-08" version="1">MAVTLPVDIWSHILSYCIEDPPTPGAHVPQPTLANALRVSSTLFLAAAPHLYSQPTVSDPGSFLLGLDRPTSVFPSSFITSQQMDYEYLKWGHKKIPLLRHLRQVTFHRPLISGYDIVVSPESTISEATFASVGYAIQVLSHLLFTKTTRISPKFEALCIRDPPQLPIYPQTVPPFAQFIQFFIRYFKPRSVCLQNADVLISSQMAKLHGPYLPENVSIHADLDWKLTVMWGSTNRIFFIKSKIAEEDDLNLGTLVIADHTEGDNQAMEAVTDIKSDEGGWEDIDEISDPPSDFASQRTQNAPSNIPHPSQSNELYLGAFDPEDLEDDYYDEYGWDDELDAGDDFGGIYDDGLGLPSYMSDFDGDDELAAVSSAELSEEEVTSMLADCLSRSFKYCRIDNRKKSRQSIQRTVFEFYGLEQLLSVDSLRYGNPDVYEQDTEDQILQNSIERVRQMVQQYVEQMLVGVGQLPVIKFLRANEAPACEGCGMTMTVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C7A0</accession>
    <name>A0ABR3C7A0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">POT family proton-dependent oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616898.1">
        <property type="nucleotide sequence ID" value="XM_066754997.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987284"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="68298" checksum="816124B57584608B" modified="2025-10-08" version="1">MTTHANAIQDFEAAPVPSAAIPSSENKTSAAGAVTLGYGDKKDSLPDVLVGDAGAIDYIEEVEPTDEEYAVLKKVHGKMPWVCIAMCAIELAERASYYGITGVVQNFIKNPLPEGGNGAGAVAPGAAGANQSAGALGRGSVQSSACYNAFVFLAYVFPIMGGILADTKWGRFKTVAIGTAVGAFAHILMVVVTIPQVLKTGNGLGPFLLSFYILSFAAGFIKPCLATLLCDQSPVKKPVITTSKTGERVILDPQTTVQRYLLIFYWCINVGGFFAIASSYSARFVGFWLAYLLPGIVYMLMPIVLVVCYKRLYKAPPQGSVTLEAMKVLYLIFKKGGFIKMFKGGDEFWQEAKPSYILAKEGSVDTTKVFWDDLFVDEIRQSIAACGVFALIPIFNLADGGIGSQENDMSTAMTLNNAPNDVISNFNPLTIIVATPIITYGLYPFFDKIGYPLKPMTRMAIGFILGMANMIYGAVLQWRIYSISECGWYASTCDTVTSVSIWAQIPLYSLPAIGEIFVNVTSYELAYTRAPARMKGLVYALCLFNQAISSAIGLACSNAIQDPYLIWPYVALAVACLFCAVLCPTYFRHLNDPVRTFADPARQAGKLQELELLTAARESQSELNEKADEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C7F9</accession>
    <name>A0ABR3C7F9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616958.1">
        <property type="nucleotide sequence ID" value="XM_066755057.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987346"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="208" mass="22337" checksum="F1C6CF2727A0D277" modified="2025-10-08" version="1">MASIEDLIATISGGLHAGQQGNDIRDLHAKLAQTINNPLPPPVHRPIPPCTATTVSAAGMPPPAPASSWNTPPPNTSFLFSTSPLSKTNGAGPRGGSAGGENGSFEVAHHVSEGWSLPMSDNASTSFTGRPLQSIMPNNNQPREEGQWSRHRNQEFTGDEPEDRPYHASVLPIKASPKDTGGFAEDAFKPLWEDPEKDQWQGFKTQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C7T7</accession>
    <name>A0ABR3C7T7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617093.1">
        <property type="nucleotide sequence ID" value="XM_066755192.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987483"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="9">
        <location>
            <begin position="346"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="759" mass="82208" checksum="5838F6A3E013D7A6" modified="2025-10-08" version="1">MSALAARRAAAAAANSKPEQPASSIEEISVPCVLTPPSPKRRKTRQTSPKPPSEAGYSGDGSSSRQFSLAAESLAEKGTGRFSPSAPNSDNGTSSPSVGDSDEDMAQEDVFEERDVIDGARDQRKASVTTYMSASGPSKRLDPVRMDITSQFNPKDNVNLCRITEGQLASAGINDGHPGPGVIVSLAQNESLAIAGLFLLTPLQHALSIYSTVLSPSLSSFPVYAPTSHPLPVISPASTQGSGISSVLNNIEFPLSFQKDFDRTLLLIRENRCGIDGLRNGAVPGFSNIWLEDSGSWELRGVHPVVGSFPVPVYPYYTPPSWSRAISSLSSTDDDLQAPFVGLVKGPKRSGKSTFARALINNLLRRFQKVAWLECDLGQGEFGCGAVVGLWILDKPVLGPPFTHPLLPSRSHCLGTYTPLTCPDEYLAAIRHLIEHYKYDLQYTSEYSALHTALDDKIGTHVPLVINTQGWMKGLGEDLLNAIESMAQPTRVFSFESQPEEIYSGQGWTSTPPWQAAQLPYDPAYPTISPVETESTQTYTLETAPVSALQARYTPADLRVLSTITYFHASLHATQSIPVTWDLSSPLVCKIPWEVELSTGKALEKVYLIGEGSEGVLEEDLPVALNGAIVALVEMLGGYEDQPVVYEQGRSPPPIDSINFLGLAVIRSLSSANSMDSGLKFQLLTPLPPSYLSRARILIKNGALELPLPGMIDWRRGGINEEGMLGKGWEEVPFLDVGGLDIIGGERRRFRKNIMRKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C8W6</accession>
    <name>A0ABR3C8W6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617186.1">
        <property type="nucleotide sequence ID" value="XM_066755285.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987578"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="136"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="561" mass="64912" checksum="03821A946A7D1D44" modified="2025-10-08" version="1">MPPKQPKTRYFKGKAPTALSESESDSEAEEEVDIKPTYKQRQKQRLEEERNLVAGGAGRVITDVKEIVREGAKAKMGGGMKMDLGNVQVGRKVGDGGVKEESSEEEESEEEEEPAAPTAKADEEESSEYETDTEEESEEEVKKPIFRPVFVPKNARNMTAEKAAAEAEEARKREEEAEEQRKLDSKELAGESIRRELAEKEAAEIVPEVDDTDGLDVEAEFEAWRARELARLLREKQAQAAKDEEKEEIERRRAMPEEQRLKEDMEFAARTREKEKGQMGFLQKYYHKGAFHQDDNLLNRDYTGATESAVDMTMLPKVMQVRDFGKASRTKYTHLADQDTSQGGWGAALRLPPGAQTTGEGCWNCGGPHLRKDCPNNNVNDPNLIGGMVIPGVSGAGVGASGANTSALGSGSRTWGSGRDDRDGRDRGYSDRVRDRDDGRRRDEGREKRYDGERQGERDDRRRDRDRDYGRDKDRERERERDRDRDYGRDRDRDRDRYDRERDYARDRDRRRDSPGRKRERDDRDRDYERGEKRRRDERDRDREREKERGERRDRDRLRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI91</accession>
    <name>A0ABR3BI91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610814.1">
        <property type="nucleotide sequence ID" value="XM_066760989.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993420"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="80"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27744" checksum="724233DDA52D1B64" modified="2025-10-08" version="1">MPHQITLHHLNLSRSDRIFWTLEELKLPYEVVVHFRLPTRSAPPSLHKVSPLGRAPALILDGRLLTESAYIIHTLLSLPEVQQAAQNGEIDVQVDNTNDDVFWSHFAEGSMMNLFQAMATVGASSQGWLSGKVPGLPEMSEDEKKGIQKYSSWIQDGYFRPNIQSTIDFAENFLAKQDGPFFSGTSKPGEGDFMMFFAIDSLIGGSRADMGFKVGANLKKWYDTILSRPAAKKAVERLKQEEGSAKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIN7</accession>
    <name>A0ABR3BIN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106349</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611052.1">
        <property type="nucleotide sequence ID" value="XM_066760780.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993204"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17059">
        <property type="entry name" value="Ubl_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="10">
        <location>
            <begin position="137"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0240553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="314" mass="33507" checksum="AF9C49766FEDD90A" modified="2025-10-08" version="1">MSRILQGVSTLDLDPETTSVDDLKLLIFSTTAIPPDEQDIKYGYPPKPLPSSAGPLSSIPIGRGEQLIVNSVPSGSSSKKAPVIAQSPSTIVPAPVASNRTNAPPILAAPLVSNASQDQGAEGGESVALPGRDAGYLQLRVVPDDNSCLFSAIGIVFEGGIEAAQKLRTVVANAIKDDPFTYSEVMLGKPIDQYVKQIQKPQTWGGAIELSIFAKHYKTEIASFDVATGRCDRFGQDEYDSRCLLVYSGIHYDAISLSPLPVSPTSFHTTVFPVTDQTIVTTADKCAICKKGLRGEKGAREHAMQTGHVEFGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIW4</accession>
    <name>A0ABR3BIW4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_106437</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611138.1">
        <property type="nucleotide sequence ID" value="XM_066760866.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993292"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0240639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="180" mass="20704" checksum="FB61D7F3E77CDC35" modified="2025-10-08" version="1">MEALPTILPPPPLPDGSEAPTRLPEKHANLVRFQSELEFIQCLAHPQYLHELHIQGYLGKPAFLNYLKYLEYWREPQYVRFIIYPTCLVYLTLLQTELFRSRLGDMGFITELMRVGSRHHATWRVENPAEATQPEEKSAVPMVTLDDDEEEDEPERGGETKGKRKKKKIRSGNVGVSQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIY0</accession>
    <name>A0ABR3BIY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-arabinono-1,4-lactone oxidase</fullName>
            <ecNumber evidence="2">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106334</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611039.1">
        <property type="nucleotide sequence ID" value="XM_066760767.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993189"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="478" mass="53526" checksum="E3CDC0AE37A99449" modified="2025-10-08" version="1">MEDLTAVDNQALQAALHPISVSSTSPLATFSNWAKTFTCKPQRVFVPTTILQCRQILELARREGARVHPVGVGHSPSDLACTNGWLVRMEGVRGTVKIDNEKHTATFLAGTTLHEIHASLASSDPPLAIPNIGSISDQTIAGLISTASHGSGVTFPVLSAHVKSLLLALPLPGTPLVRVSQNEDEELFKASLCGLGATGLILEVEFEVEDAFRLRETKEGKAIEEVLESLDEIKKSAEHVRVWWYPDGKGAVVGRANRTYDPAQPTADFVGHILGYHVTQFFLYVARVFPSLTSLVGRWAWWLSKEDSVRVDDGYKILNFDCLFPQYALEWAIDAKEAKSCLQEMKIWLDREAADPAGLRVHFPIEIRWSCSDDIWLSPSYGRDTCWIGVVTYRPYGLSVPYREFQDKFSSLLQSYGGRPHWAKQHVLGPKTLEVVYPKFKDFQQVLRRVDPNGVLLSENVRRHVEGENIPHRMFERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ87</accession>
    <name>A0ABR3BJ87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sulphur transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_106021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611231.1">
        <property type="nucleotide sequence ID" value="XM_066760470.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992876"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046513">
        <property type="entry name" value="DUF6691"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20398">
        <property type="entry name" value="DUF6691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046110140" description="Sulphur transport domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0241849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="36283" checksum="F896A4AF027ADE46" modified="2025-10-08" version="1">MPFTPVHSFVGALLLHLSTSQILEDTGRVFGISGIVSGAVLGGREGWRWAVVSGLVAGPALAAVTGVKGLFPGQGLSALETIGKGKLALAGLLVGLGSRTSNGCTSGHMLCGVARLSVRSIVATVTFFATAVITGNIFPQYPIPSTPAYSIELPSLPTTVALICVPLVARFTLQATSIALIRMKSVPKIARLLPYFVSSLIFSIGLSLSGMTDPSKVSAFLRFPNPQCWDPSLLVVVLGGVLPNMIHYAFLINKNKKLGNGQSKPKPKFNWESWQVPTRKDIDSELLMGSAIFGVGWGLMGICPGPALVSLGSALIDLCFGSGSWQGLGKVSTFLGTMLLGMAVGGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJB7</accession>
    <name>A0ABR3BJB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611273.1">
        <property type="nucleotide sequence ID" value="XM_066760512.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992920"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0241891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="132" mass="15253" checksum="9E82123294FCA782" modified="2025-10-08" version="1">MDFTFGDLFEKKIFEALDTCVFVVISTAIRQLPINIFISGTVDHSVFTVYIPKLEHTSTLGSWVIVSDIRLWVTGYWISFLVFLFWFPWILRLWISASVAALWSGYTYHLIGCNSMPACFHFLFEGSTENYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJK1</accession>
    <name>A0ABR3BJK1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane anchor Opy2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611161.1">
        <property type="nucleotide sequence ID" value="XM_066760889.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993316"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018571">
        <property type="entry name" value="Membrane_anchor_Opy2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09463">
        <property type="entry name" value="Opy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane anchor Opy2 N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="619" mass="65910" checksum="C8E1C7553A20C8DB" modified="2025-10-08" version="1">MSHPNELFPRMDWYRRENCVTCNDTTPTCNCSSSEKCILSSRTCSQCPTIQCIAKSSSSGGSSVSAGAIAGPIVGALVIASLGLFWWMRRKKRRDLKRVEELAERARKAESAGFQLSPADSPAPVSAHSQPPNPHGLPLPPPSASRRSPLPPAPVNAEYYDENGATIRVYSTNGIINADPNGDPFSDRQSISTMGSGGTANIIPIQWIPPSNSEDGLSKIATRPGQSAAARALDQARQNLFKPGVAPTRPARSPGLDLRLNPPSSFDPKVLESSDTNAYRDSYLSGNSAAPSYFSGQSDLNIDAPKIVTSKQVQIGRLQQAEMVQFGGKSAQMMEVLGGSSMLGSTQDGDYSFDQHPAERGIWPAPGLSPSDASFRSGRTGEAVRTLTPMSRKFDEEERLESGSTSPGDLRFSMGSLAYRDSTSTMDTSRYLTSAITVAVPTSGVSPTLLSTTSTPRTANPETRASVVSSKSYADSVLGAFPMIPPDSHHPPLPPNAGFIANSNSQPHFNSTIHTSVPHSTSVDTLDRALISRPPPSYRPPPPGPRPPSSARGSTAADLLREQREKEDGEVDEREEGAEGKKKRPETQASVADSLLGSFPFVPPNVDDLAGLPSPSQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK18</accession>
    <name>A0ABR3BK18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611110.1">
        <property type="nucleotide sequence ID" value="XM_066760838.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993264"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="65"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="469" mass="51600" checksum="3FF54C61A68AC9BC" modified="2025-10-08" version="1">MTSLYTGTFVDAPTSAGLRVRRNHLLAVSEQGYITHIAPLSEPASQALLASCPSPTKLGNHSFFLPTYADLHLHAAQYLYAGTGLDLPLLEWLERYAYRAEERVDADDQLAERLYGRLVERLRENGTGCVVFFGTIGVQANLILAKKVQQAGIRAFIGKISMDESPRPSYGEASSSASLSSLHSFLDSMESYLSQFPPHRRLVQPIITPRFVPVCSDELLQGLAKVAKGRNVRVQSHMCEGRDEIDMALKTKGLDDEKVFDKFGLLGPQTLQAHVTYLDGGLARLIKERGVTIAHCPLSNQYLSERQFPLREALDASLSLGLGTDIAGGYSPSIHTAMRQAVIISRMREGDRCESLGCSFGTAKKEAEGGGRNLRVDWKEAVWAATRGGKAGMGLGGALEVGMEFDVQLIELASEEHPTGTGPLDFFDIADSQFDTDTDEWWFDALERWWSNGDERNRKGMWVQGAKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK49</accession>
    <name>A0ABR3BK49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611541.1">
        <property type="nucleotide sequence ID" value="XM_066760237.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992643"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="628" mass="70043" checksum="FA4490A331D234CE" modified="2025-10-08" version="1">MEPPHPSASPLCLRHTLEWLEESPPNLSNTKDNVVGDILEALLLAEESPWVEEYVQSLTVNLFSSLFRQGRAIRKSGVRWSWRGLHDIGILRVRLESSPYDMTYIQSKYHRIFHDWRKKGRGEDVPSNAGVRRPDGMLLAYTSYRFASTDEMPQLAVVDEGKIDVPPSDIPHCRSASRTTAKSAVSQVTQTGSHATSEKVTPVVSPTPSKPSTRISSTFVKGLHLDPCEAAYIITPLTMALKAEESDVRIVLGYFGHGTRYCRAIILDGETILFETTDEGGNLASLGGIGELLHFMGDKTLPRCYGTHDKPDVKAFEDAYDFALTGLRMVLDLPLGERLCRLKAPSGESWERLMDELQMKVKYPKTREDVECMFGILHPDIARKNEQMRLYKGAAMLDKMSDILSQGTTTETADTVESQQGDKSEVTEEVKTRKAKKKKALLPEAGAHQPDTRFRGPFPSSDGRRGREMGRGASRGVDGSHRVDRSSRKREAASPEDGRNQKQPKSNENKEDVLSSVSVESADSVPLPITPPDIVSQWLFDPFTNELCASKEGLKMCSGVNNGPENGKVHSPRGDEEDIVDEMKRREEERKLYLALYSVLEKRGFRFLLGGQKVFQAVLKELADQYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK66</accession>
    <name>A0ABR3BK66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_106470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611170.1">
        <property type="nucleotide sequence ID" value="XM_066760898.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993325"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="179"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="385"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="484"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="503"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0240671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="597" mass="67607" checksum="D789C21EFF9F8B80" modified="2025-10-08" version="1">MEQQPSSYPPSYHISTRQPSSDPYAPPSSMHHYRDGQPVKPRTGSGSGSVSSNHLLSDAERGGGRSGFALPNKEGDYPEGWTKEDEEAEREFMKRGMVDWDELKSWRFWIRREWWYYYIIVAVICVLVVLMSVYHDDIVTWMKPAANWMKNRMGHSYRRIFHHFLSSSLWPRDRRNPPGTLIGEIGNFYAFKYCLRSTAEKYEKNNINYACLAHVVREGGFFIIFVARMSAIPGHFTTAVFATCGMNIWIFTLAAVLSLPKQLIVVYLGVMFDSQEKSTKEKWISHGVLIFGFILTLWSAWYIWRKMQQARLTVWRRRRMEAAAQGLVLDPIALTTTTRPDSLSGGRVGEGGVQSLAYDTDGNGGEGYTHKQWNRVVPMIRRHREGEEDEAQNPILREHSRDERDEREGRVGYGGLGVPGGRGAADAGRYQSYQNPYDVRYQNANEMSVYDVDVDANGPLIHAVDERDITYGYGYRPAASSETLLSQQVPVQPQPQPRHQPPEGQSSTHHLPSYSHSQSQPHTHLQSHSRSAPNSQPQETLVYFPEAHSTGIESTPDGHVAPAGQSGTTVHRSATKATVYAKEEESVSFPRPKPNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKK3</accession>
    <name>A0ABR3BKK3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YbgI/family dinuclear metal center protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611704.1">
        <property type="nucleotide sequence ID" value="XM_066760400.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992806"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="293" mass="31802" checksum="E0E25D3957CD3F5D" modified="2025-10-08" version="1">MGGSPQITPLALIKRVWERIAPLQLAERSWDNVGPIIEAPYPNPSHRQVLLTIDLTPSVCAEALKHPSLSLIVSYHPPIFRGLKSLTLSDPLQASLLKLSAKGISVFAPHTSLDATPNGINTWLIKPFIPLSISHDPIIPSDPLESFEGAGMGRIAKLSEPLDIGRAIKMVKEHLSLDFIQLAEPQPDVRKPIKSVAVCAGSGGSVFKGVEADLLITGEMSHHEVLAYVASGTTVILTNHTNTERPYLSHVLQPWLQEELNKEAKTQGDEYGPNGGKWEVLVSKADADPLRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKM5</accession>
    <name>A0ABR3BKM5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA-binding protein VTS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611365.1">
        <property type="nucleotide sequence ID" value="XM_066760604.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993012"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="603"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="284"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="524"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0241983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="684" mass="72484" checksum="D5DF597E02219E70" modified="2025-10-08" version="1">MASHTLRPHRSPSPSPEPPVNLANPAKLTRQSLGPPTSGNSKGFGSLGLGPGLASPSSPSQPRHVSSSVAMGMGNRESLSPRPSGIGSGRAVSATTGPRPSSEFIPTREAKTPETEQIDQWFKHLANWEATLEEMAAASTDQNFTEELGAIEQWFRVLSEAERTAALYSLLQYSTPVQIRFFISVLHHMSQSDPMSALLSPSLSGNNSFQTQVESKLSNMNLKSPSAGGGAGFTGSPGNGHYLAPDDAATKAAKARQNRISAPGTLQPHDRWQGQLDQVIERGTSPALESNISGRSRSKSPTPEPRPKSTDFSGKPRESLHRDSTAFPRSPRVSAGSPGIGLGIGRESPMASPFGNNASWASMVNTPLVQNYNDGKLTAPASVADLSHALNMATLQLNSPGYLPLDDARKYRRPTGGLASGQTSRNVSGQYNDDGEIVNPHTTQPGTSSGLLPNQFGTAGRSPLVDQFGLGSLGIGADPATLANLGLNYSLAGLGGVNPGLNGLTTAQAQAAQMLAMQQQLQNSPYSPFNTSVSSLQPGLNPPRRGVSRGQSSHLNQYQQQLQPGRRSPNPMKSHSPAPGQQTGGGGAGGGAGVAGPEDVDVRILEDVPNWLRVLRLHKYTPNFEKSNWNDMVLMTDQDLQDNGISAQGARTKFLKVFYNVRTKMDITHPPGQEEYAPGPKDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKQ1</accession>
    <name>A0ABR3BKQ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105984</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611737.1">
        <property type="nucleotide sequence ID" value="XM_066760433.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992839"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="288"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0242355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="569" mass="62004" checksum="64474A1CA6895E40" modified="2025-10-08" version="1">MTSQPENEPVPSASESIQPTDPNTVAEPVNSSSTSTSPSAATAAAAVAPAAIPSSHAHPAFPSLPQPGKLPSTPQEIHEILSLPADQFTAKGLPLLAKVADGKPFEGASLKAWERRNAGEQLLTLYEAGDQVYETTDERVKDIGGGLVYVLSARLNLGQGNPVIWSDKMLDFAINLCELADPVQLRICHQRVSAFAWCLLRLSQQLSKVELIIPAITSLIQKLNYHQTFSPIFGVLLEACLITRQYDHPSLGLVLDIIFLDVKTTAPTYLDILTYYHHAGTVIMAMGDFRKAKEYYLTAVTAPTMTASAIQLACAKRALLCELIVTGKKILWPKYTPTPVTRIIEKYAVQYNELAKQFEAHNWGAVQKAHTLPEFEKDCNKGLIGQVIDSIHRHMILRLRKTYRRLTVDSLARRLRIGDNLPKAERVVAILDDMIQSGEVSATLTPSVTQPQSHSQAIVEFITTAESFTSPAVLARLEKTNALATLLQVHLEEGSRRLGASKEYLRKQAQFLEFNSKKDKGDDFDQLMEAEEAMESGPGSGKMTGSGGGGGSKSGSLRGVSSNMADIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKZ0</accession>
    <name>A0ABR3BKZ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611832.1">
        <property type="nucleotide sequence ID" value="XM_066759886.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992286"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="839" mass="88359" checksum="F3294667B96A175B" modified="2025-10-08" version="1">MPFLQTLNDLKDFTHSINPLSLLSPDQQPSPAPSSSSSPSQSAALPNPSEAGPGPSSLASRNSAAVNQRSIYSSPPSSSRPSLKHSSSSSLPPSSDSAESAPRPRGASAINDRRKGSGTSVVVIADPEVTNMTRGRQKRPVSVASGFTDDGGFGDRRGKKNPLDTYIIVKPPPASAKNPLNLQIQLIVKRNRRARGISTSSNYSSLGSSPADDRGVKLQSPATPNLPSSAPMSPSTSMTGGSSSLPASAATSDVSDDEASIKRSSSIRSGMSNATSSTTSGMSGKRIEPMFNLAVHNVVHPTVVTDAATDVKVAKFHKRVVDVSGVGIVEPTEIHLPSASNHLYPTISRVTSHVTSDGETLQTPGTKARPLSIASFSPSLSPVTTIHQEESRSLRSSLDLKNFRLDNILHHQKPDSGDSNTKKLFGKIFKKKKNVEKPEDAAIHLTRSASASSIDPKGTSAIPSNAVSPTNGSPAAGRASIHLPSTPSDFYHASPSAVGHPTFGTSPNIVIRQPPSAAHALESRLKPELYSPTEKHHTISSRSRPIGYNWTVRRWARRNSEGWAAHLVAAAATGLELVGAAEMAGENEVKFEWVKGVFEPEDEPSQRGLGIGKPGGINLGQSKMGRAVSAPGRSVSTETGPKSSRRIASPMPSTPSSPAASRPPSPSFDSRPEPVRRVSAAASTSSSTASSKGIPSVAFDDAVTGGGETAGEEGDSSETEDSETPWSCWVWVKSTGQRQLLGTLTPAPHHPKVVGVLKIPMSLDPVSLTDIKGPPLNAVNGEQGQRTAMAMKRIKENVALTEENLKDMLCVTALWLVAREEYGGLGRVGGRRRRGKRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL26</accession>
    <name>A0ABR3BL26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611867.1">
        <property type="nucleotide sequence ID" value="XM_066759921.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992321"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="6">
        <location>
            <begin position="764"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="579"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="616"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1008"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1043"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1084"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1099"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1127"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1149" mass="125032" checksum="40B800CF0F07CBC1" modified="2025-10-08" version="1">MQYLSKAYNYYSGINPATLSGAIDVIVVRHVDTDGTVTLSSSPFHVRFGKLQVLRAAEKRVTIRLPNNLPAPHVAPFHMKVGETGEAFFVVETDEQVSEDLLTSPVVMPIETETPPSPPLPDEHPQEEDHRGSLTQEPFGDTEQQVPPHESPLGEVDFLDLNASPPGTPNKPRGDTHTAANIPNSLTKSSLLGTASSLLPGPLKPSPSKYFDKNPPPPPLRQPSIDDGTPNGNDESKAKQSSHPVVSNTNDEPNPMQAHPGEKAGLPLRDHKLEKLKSDSHNITAGVKAAQGEEGLPKVKAGQGEGPEVVYGKDVVLDMDGYHSSARADGSASENEQDGPVEMFIQDLLASVQPAASTMDDRPKPRKSRSADTEVPSSRSDEDEDEDGDAHTPVEYSPRQDDSQSLSISNPRNRAPTRNRLDRGQSEPPQLQSQDDLSRSPDRGAKAAMEMEWDWGRRKPVSSDDEMDERGSTSISRLPLGRLKNVEENPYMFVLEVGKRTHMFELALCEEWGHNSTEASQEAAFTMNRLTFQTFIESPTVVDDPNIVVRYNDLFFTWSSGYRLLYALSMYRRVLVPPAASPSSPTLPAMSLSGLSAGEQRRRSEGRVGTGEATQRQSGYGWSRWWRRGQSSGSSAPQGSLPAPGKELHREPKTETAPARTTPVPGTTSTDVQGQGKEVGSSGTETEAGTRAGLQEEDGNVGKASPSEEGKKNYAKTLRLSSEQLQQLHLKPGPNTVQFSVTSSYSGLATCVARIFLWEDTDQIVISDIDGTITKSDALGHVFAAIGRDWTHPGIAKLYTDIGNNGYKILYLTSRAIGQADTTREYLKSIAQGQYRMPEGPVLMSPDRLMASLHREVIMRKPELFKMACLRDIQRLFGTQAKEAFFAGFGNRITDAMSYRSVGIDASKIYTIDSTGVVRTELLQAAGHKGSYIQLNDLVNEVFPPVSTKFKPEYTDFNYWRDPVPEVALPDFSPPSPALSARSDTSGRLSVLGKIAGIGRRSSRATTGHAHSPSSASISGASQLDLSSRPSSPLIAPSLTSDDLSEVEDGEGEADEQRSLSSMPGSFEDDRGKHLNDPFFAPHSQGQQSRSSRSLGDQKGGRGEEEGEGKEGREDGEGEREGGDSYSYDDDAIFDDDILAAGEMQHVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLF3</accession>
    <name>A0ABR3BLF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611981.1">
        <property type="nucleotide sequence ID" value="XM_066760035.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992436"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11395">
        <property type="entry name" value="bHLHzip_SREBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1012" mass="109864" checksum="DB906A7596EA987C" modified="2025-10-08" version="1">MPTSLYNTQFDQEEQDSIFLSSDVLPTDALFPPELTAPFSDSQFLFENSSDDLGRYDQRRASLSSNEDSLPFLSPTNPQSMSSTSPRHSLSPLTGEPSFHPTSHSPHSHSSASPLSSSGTDDVLLARSFEGVSSGELDMFLLPEPSNDYPVNSDGFGGQKSGQSLFLPGRTEGFNGMGDEWIQNLFKDPVQGNGFDDINQQPQPQSGGFDFSQILAGLQQQSQQQPLQQLQQQVGQTIQPQMVKQEPLVKQDSWGHEQNLSNSQHGFTFTHPSFAPTNQLQDVKSASIPRTASVRRPTTFKTEAVTAAASTPIGKHNKTERRYRQKVQAAQADLRDAIPALRLLYGTSTPEQLATTDIRAPDGTVDGLGEVTRPNASAKATILIGARVYIELLQKRSAKLQRMVNELETFRRAVEGEAGLSAWKEDFGRREAEIERVEAEQLAAKLKDEEDESEGEDDDADEEPAKKRKRTAAPRAKPKAATKTKIIPQSTAAVGARVFAAFAMSFSFVPSASTVFRAPPQPQALATDKVLGHATNQQILARVPLIVAEHTSRLLARSLPGALVPAPATLLEWVWRLVVAVVLAVAMRPIISKWTTKSDEKIRPGTVEGVLKDVVGIVSRKKVQKTEWERFAAGVIGGANNASTLAKWHTILHLNVTASSPYSLALLALLQPEFPLLRSPRHIWFTAQSRVDGTTPPALVTVLGLPLHEALRCLSSLPPTSAPLSALAEQITLIHVHDLYTRFFIHLVEASTISPLSTTSLKSLLSALESHNLGANLKASAFDKEIKSVMQGTQKGSVVHALGLVLIGLWGIFTGPSPSAQASLAAALATEQASGASHGLSSVSALLELLYPGCAPISQANALASPPLSPNAQKVDTLALSIIEYLSLLLTTSRSTEAATTDREGRKEESLGVQRKVVKLRGVLNKTGWVGVESEVDADEFEEVYDQPEDFTLGDEADKRDFRPHQLESERIHYERAKERLVDILAKIGRRAAGRASGRDEDSGLEGDLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLI9</accession>
    <name>A0ABR3BLI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612027.1">
        <property type="nucleotide sequence ID" value="XM_066760081.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992483"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03427">
        <property type="entry name" value="NUDIX_MTH1_Nudt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758">
        <property type="entry name" value="7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758:SF2">
        <property type="entry name" value="OXIDIZED PURINE NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="89"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="299" mass="33837" checksum="71DB11939433D1E9" modified="2025-10-08" version="1">MMHHPDQPTSVAHVAHRRLGYQAATNHRLVWAGVWSTYTVKLRPYYLKQKGMACSSIPTEFNKLPIEQSPFSSQTPVRNWVHLQNIKPWPIEYSLVFVVDRQTSKVLLGLKRRGMGVGLYNGYGGKPEPGEPMLDCAVRELHEESGLVVNRFDLHHKGILLTSRPDLGTQHEKSLLRIHIYACTSWTGTPATTEEMEPKWIDIADLPLEKMWPEARKYVPPLLQSILQDKLNTEMLLARVDYEYLTSVQAPTPLPPLLGLSISFENGDGDDLPMERLSGWWMTFTTARILSLVAGNSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLL0</accession>
    <name>A0ABR3BLL0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_105915</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611668.1">
        <property type="nucleotide sequence ID" value="XM_066760364.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992770"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1052"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1082"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1107"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="13">
        <location>
            <begin position="389"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="600"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1224"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1224"/>
            <end position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0242286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1262" mass="141436" checksum="678D326B6F7A2F47" modified="2025-10-08" version="1">MSRPHLQQNVSFEDPKPPSRRSGRDDIPPRPPAKSDPSKNSLTTTTTVQSVGGYTNHQLNFDNNAYVDVGASNPQGFSDYEGVRRKKSMVRPERERIDPNHRLWHYREHAAEDQVDIQPSSTGNQPYNQYNNQRSGANLRRGKSLLARETDDVDDSSGLNIFKRGATIRRKESRAMPRQAPSATQSNRVGGGQKDDDDCCCLGNFAPGPKDCWMVYCYLLTICIPGFVIAKVFGKKTPDAQRAWREKMGIVSIVTYLMAAVGFITFGFTQTVCGDTQLRLPGGSANTGSLVINGYDYDFSTWRHPAAGDIFNGSTSPLYMDQYMAGGMDASFLFQNTNGDQMGWYFPCNLHDQNGTSAANLTGITDSINCHVSSYARSNFSAVVPTAEIYYTWDRVKDESRNLAVYKSAVIDMNLLQWLDDSQVSYPAFFNTIKNRNDTYAGKDITALVERANLTQYARCLTDVIQIGFVDTITIGCIMSDLVLYVSLVFILGAVFIKFGMAVVFGWFLSWRMGNFKGESYQERMKRAAEIENWTDDIYRPAPGYLRPNATGTARTGVKKNFLPTTSRFSRAEPMLVSSSRPSTSYGMVGEARRQGSSIYANKLGPPLHTTPPGSPLLRNSRSSTSLPFREDSRHSISDRSVNNMMPCPFPLGNVVPQPAPDFEPFGYPLIHSICLVTAYSESIEGLRTTLDSLATTDYPNSHKLILVICDGMVRGSGSKQYTPEIVLGMMKELVTPAEEVEAHSYVAIADGHKRHNMAKVYAGFYAYDSETVEASKQQRVPMVLVSKVGNPLEVNDPKPGNRGKRDSQIVLMSFLQKVMFDERMTTLEYEFFNALWRCTGIPPDRYETVLCVDADTKVFPDSLTRMNACMVNDHEIMGLCGETKIANKSETWVTMIQVFEYYISHHNTKAFESVFGGVTCLPGCFSMYRIKAPKGDRGFWVPILANPDICEHYSENVVDTLHKKNLLLLGEDRYLSTLMLKTFPKRKMVFCPQAVCKTIVPDTFRVLLSQRRRWINSTVHNLCELILVRDLCGTFCFSMQFVVFMDLVGTLVLPAAISFTMYIIIISIIPKSVTGIPRPIISLILLAFILGLPGVLIVITSRKVAYVGWMLVYLMSLPVWNLILPAYSYWHMDDFTWGETRKIVGEVKEEAHGGKEGTFDSSHIVMKKWAEFERERRWRTGSISRDSQYFDVVQRANSPRSGIPSNRYSIVSTSETFNSGFGTAESNPLFRQSQSFASMSQVAPSPDTMKKSLRNGKEGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLP1</accession>
    <name>A0ABR3BLP1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612071.1">
        <property type="nucleotide sequence ID" value="XM_066760125.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992530"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0243704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="299" mass="33396" checksum="379CFCBA3737C1B3" modified="2025-10-08" version="1">MPFGEITLNDGRKIPAIAFGTWKIPKEKTPSQVGQAIDVGFDHIDTAQIYHNEGEVGQAIKESGLSRNELWVTTKWSGVEEKGARQSIKESLDKLGLKYLDLYLIHSPRVTKGDIKGAWKELETLQKEGKTKSIGVSNFNKEQLQELLAHATVKPVVNQILLHPYVITQTAPLLEYLKEQNIVVEGYSTLTPLTSRPGGPVDQPVNQIAKRLSIKPEQVLLAWSRAKGAIPVTTSSKKERLEGYLDVGDITLTEDDIKAIDKAGAKGELWFERKARFGKVFIRVVFLMALFWLLKAYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM47</accession>
    <name>A0ABR3BM47_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612237.1">
        <property type="nucleotide sequence ID" value="XM_066759590.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991989"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="140"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="448" mass="50101" checksum="3ADF8B5B5DDCC630" modified="2025-10-08" version="1">MPFLPRASFPFSPHTPSWFAGHMARSLRELPPLLENINLVIEARDARLPLTSINPIFDGVLRRWKARAKIEGERERIVVYTKRDLAETRFEGPLTKAFMRNDSQKIMFADTRKNPDVSHILRYAVDLAQKSAPFSPTYSILVLGMPNVGKSSLLNALRRVGLRKGKAFQTGAIAGVTKKLTGTVRIYEDPQVYVYDTPGVMMPYLGKGEEGGEKGLKLALTAGIKEDLFELDAISDYLLWKMNRRYVSEPSLPSYLSSLPLPPSFEPTDHLPTLLSALSNRLAAKQKGGDEDWESVMRWFVRAWREGKMGEWTLDELVPYRPAEVLLPREVENMPLERETVDLPVAGVPERQMSQVELESHVNGAVTAYLSTLSSSTSLENPASASQQRKISKSKRLQEKDAKLRGKGINVKRREEWQPGGVVSGGKRKGMSVKSTMGAAGRAVRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM51</accession>
    <name>A0ABR3BM51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Threonine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_105141</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="11"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612245.1">
        <property type="nucleotide sequence ID" value="XM_066759598.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991997"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04906">
        <property type="entry name" value="ACT_ThrD-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="12">
        <location>
            <begin position="445"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0243878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="526" mass="57632" checksum="81843905F56D71AF" modified="2025-10-08" version="1">MILTCELLWRRNTLIHAAKVYSAPLNLKETPLTYAVNLSARLGNEREDLQPVFSFKIRGAYNMMASLSDEEKKKGVITCSAGNHAQGVALSGHALGIPAVVVMPVSTPSIKWRNVQRLGATVLLHGRDFDEAKAECLRLEKEKGLTFVPPYDNPYVVAGQGTVAMEICRQVTDADQIDGIFAAVGGGGLAAGIAAYMKRVAKPSVGIYGVETVDGDAMARSLKAGKRILLDEVGPFADGTAVRLVGEEPFRVCKHFLDDVVLVNNDEICAAIKDVFEETRSVPEPSGALALAGLKAYIIRNNLQGAGKRFVAVISGGNMNFGRLRFVAERADVGERREVLMSIRIPEKPGSFLKFHSLLGSRAVTEFSYRYSNDSTGYIICSFLLSSSSSSSSGPSPEARAKEIHEILESFKTHGIEAVDLSEDEFAKSHARHLVGGRSAVEHERIFRFEFPERPGALGNFLKGMKVEWNISMFHYRNHGADVGKVLIGVQVPSQDYPAFDEFLETLGYPYVEETNNEVYTMFLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMC3</accession>
    <name>A0ABR3BMC3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611103.1">
        <property type="nucleotide sequence ID" value="XM_066760831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993257"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="75" mass="8102" checksum="F088A31B2F2BCC50" modified="2025-10-08" version="1">MSQSQPQSHTVQSKRDTQSGGRGSAASGPNSGADRGIEDGLPYTVCPVFDYLLTLSRSIAKVKQGRPRDISRCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMD3</accession>
    <name>A0ABR3BMD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611769.1">
        <property type="nucleotide sequence ID" value="XM_066759823.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992222"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13447" checksum="4669EC31A292336C" modified="2025-10-08" version="1">MNYAEFRSLVALFGDHTIFKSKGRKPQAPPEVQLATCIYRMAGGERESTVENHFNLSHGSVSHYTDRSIIAIASSLRQYITWPSGAERAALARELYAQYGLPSCVGFIDGTDIVLHQASVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMF5</accession>
    <name>A0ABR3BMF5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bromodomain-containing factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105238</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612342.1">
        <property type="nucleotide sequence ID" value="XM_066759695.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992094"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05500">
        <property type="entry name" value="Bromo_BDF1_2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="226"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="419"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="5">
        <location>
            <begin position="616"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="556"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="691"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="699"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="754"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0243975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="83918" checksum="E6C7123DD22493AD" modified="2025-10-08" version="1">MSEATATETPVPPPSNVAEPPKSPNPLNPATDAQGENIQPLAQPQPQSDVQAVTAAPDLPPLPVDAPLPPSPAASDEPPPSLPSSAIPTAVPTPAVITVGEDKPEVPAQAPLSTVTQGSAPMDLDESTPQPVKRAGEELDGERDEKRLREDASAVQAAAEAGEATGEAIAVAVQSDVPLVGPDGQPLPPPAWLSYVPPAPKFAGPNTPLTLTQHKYMLNAVRSLKKRLPDAYNFLVPVDTVRFNIPHYHTVIDTPMDLGTVETKLIVSDPRGPPKDKSKMSKWDTSKGKYNNVAEVTEDVRRIWENSRKFNGKEHPVSQMATRLEEAFERSLNNLPAEPVVASPASAGPSHVRRPSISQPPVVRRSSDDTRPKREIHPPPPKDLAYEESPGSARKPKRRNDPQLQWASRAIKSLESSNKYYIAVSPFLYPVEKIIEEVPDYATVIKRPIDFNVIKNKLNENSYEDVNQVDEDMRLMVANAQKFNPPGHEVHTSATQLLQIWDEKWRTVPAKVETRDSSEDPMAEAFDDYSSDEDNAQLRSLEGQVIALNQQISALRSKMTKRRAARGSKSKSKPKTAPRKSSISKPSPNVNGNGQPKKPKKASKEANLMYREDDDESEEEEDISQLSHAQKQELAEKIGQTDGETLSKVISIIQQSTNIGGSNQEIELDIDSLPPATVIRLYNLVCRGGRGSGSKRGRGGGGVAKKAGGTGRKAMGGVSRRSVNEREEAERIRRMEQQLQAFESSRPVPQAVGYEEEESSSEEESSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMI2</accession>
    <name>A0ABR3BMI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611829.1">
        <property type="nucleotide sequence ID" value="XM_066759883.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992283"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7937" checksum="C13AA8A48D577BEA" modified="2025-10-08" version="1">MSGVYRYTQRLAHEKPVIFWSLLLGLVGPVMVIGVPPVRRSFGYKSPEPIPSTFPLPNRPRQPVKGYEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMK3</accession>
    <name>A0ABR3BMK3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611505.1">
        <property type="nucleotide sequence ID" value="XM_066760201.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992607"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="312" mass="34496" checksum="1800E948F85033EE" modified="2025-10-08" version="1">MLHSISIQSTDFPTKRLRSCLSPARTRQHSPSFLPDSEAAVAITTWKRVKTVRWQEENGCAVTSFHDTYSHEEYDRSPLEPPTSAERDCVLPERGSRCLSGPRECFLGDFSDEEEDIPTSASDFSDSFVIHTPPSTETNSDDGEPRCDVDDEGKMHEGDDGWDECMQRRRMMFARLCTRENGDRHPEFEGYRSLSATLAQLLKSVGCNDEDDLAKTDDDEETAEEDDDEAEKKQSRCQSLDIFGLPILAQGSVTPTGTPSLVSTEESDAEYTIASPGMGTPADTLSLNSFGFEFGFGSGSASVRQKAFHSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMQ7</accession>
    <name>A0ABR3BMQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612286.1">
        <property type="nucleotide sequence ID" value="XM_066759639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992038"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="415"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0243919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="82564" checksum="0BAA1590D90B6F75" modified="2025-10-08" version="1">MSGNLIDIPEVHFNEEPQPVFDYHSLDGQSPAICIDNGAYSWRAGFSSSSAPYIDRINMVSRYKERKFGKNILLFGGDTDADANSRSNARSMFDGDLLIQGDMLECALDFTFCQLGIDTPQIQHPIIMTERLANPLFSRAMTSELLFELYNAPSVVFGVDSLFAFSRQGKKDGLAINLGHQATTIVPIFDGQALVNRSKRIPWGGSQASELMLKLAQLKYPSFPVKVTQSQATFMYRETCYFSTDYEEELRMLEDPAKLSAMTKVIQFPYSKTEAAEKTEEEIAAALERRKESGKRLQELQAKKRAEKLAATIAELEEYKLLLSERPTMKKADFLTRLSEDTPFDTEAQLESWIKRTEADVRKKQRRDLGLEEEPEEVPTFPLLERPDEELTEDEVKDKKRQRLMKGAWDARMKVKEEKRKERERMEEEKRKEEEERETNLAGWAAKLKDQQDAVISRMQERKKRKAQLGDRKSAASQSRMKHIANLAAEEKTSKKRKKGEDDDGFGMDDSDWAVYRAIEGEEDSDAEEDDNNLLQSIETRLLQYDPTFTEDQTMLGRAEAKNRLINAFVRGGNSEKFDPEDVRQNHQLHLNIERIRVPEVWFQPSIVGLDTAGVGEVAGWILNGFVEEERKRLMQGIFVTGGGANIPNLIPKLRQVLTPILPFRAPLKIVSSLDGGDPRIEAWRGMAQWSATEEAKQAMVSRAEYDEHGGEWLKEHRWGNVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMS7</accession>
    <name>A0ABR3BMS7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612458.1">
        <property type="nucleotide sequence ID" value="XM_066759811.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992210"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0244091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="126" mass="13426" checksum="8150CA64FFE41AEB" modified="2025-10-08" version="1">MSKHEVVATDAAPKAIGPYVQAVVHSGVLFASGCLPLCPESMKIQGSEIKDQTTQVLKNVRAVLMAVDVDPSNVLKTTVFLQSMGDFAAFNQVYAEFFGETKPARSCVEVAKLPLGALVEIEVSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNH6</accession>
    <name>A0ABR3BNH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612694.1">
        <property type="nucleotide sequence ID" value="XM_066759207.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991600"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="61"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0245610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="499" mass="55017" checksum="4FDEB4ECDDF7F08A" modified="2025-10-08" version="1">MSLEEKSSQEYLEQIISEKDKFDDGVDRHLAVKIPDSLVGLSDEEISAIDKRATWKLDLLLMPVLMALYILNYLDRQNISSAKIAGIMDDLGLTTTQYNTCVAVLFAGYVSLQVFSNIFASKINYPGIYICFMCAVWGVISGCTGAVQSYAGLAVCRVVLGFAESAFFPGAVYLNSCFYTKKQMALRTAILYSGSQIGNAFGGLFALAILNLNGVHGLKGWRWLFIVEGVLTVGCAIIFATFIPNKPGTMRWLSQQERDRLVYRLEVDRSSKDATDEVTAWTAFKLASCDPKTWLLCSVLYCNYIAASVTNFFPVVVSGLGFNRTITLAITCPPYVLCCFAILIIGWHSDKKNERTLHIICPFFITIIANIMAISTTKVVPRYIAMCLLPSSFYGATCCVLSWISSSITGPAVKRAIAIAIINAVCNTPNIWTSYLYYDSPRYLAAFGVDLAASVLTIAFAALTYLYLRRQNSKIERGEPLPASGPSVVQLEAGFRYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNK0</accession>
    <name>A0ABR3BNK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612731.1">
        <property type="nucleotide sequence ID" value="XM_066759244.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991637"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0245647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="156" mass="16859" checksum="129432EE1A7A5EA8" modified="2025-10-08" version="1">MSSRKWYNLEAQTDDAIFGGNESAFSALGLTRTQRLGGFAACFVGGLAISLLGAILLFLGATGAFATLFAVGGIISLIGTGFLIGFKTQLEKMFKPVRIIATVLMLASIVMTFVSAFVLPTILCIIFVIIQYLAYLWYALSYIPYARTMVKNMVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNV3</accession>
    <name>A0ABR3BNV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612831.1">
        <property type="nucleotide sequence ID" value="XM_066759344.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991739"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF44">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09754)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0245747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="170" mass="18956" checksum="2B81C1B6E640AC27" modified="2025-10-08" version="1">MPVLLEGTCHCKSVKYTVESNTPVPFQLCQCSICRKVGGYMGSVNMMGNTKTLNIIRGKDKIKVYVAAVEFDENDKPTKMGNSKRSFCTECSSMLWNYHDEWPDWIYPFASSIDKPNPLPSIPESASLICIMRDSCPKHVPVPAGAKVYGGYGPGDSIVGWHKENNRWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP52</accession>
    <name>A0ABR3BP52_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0246977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612938.1">
        <property type="nucleotide sequence ID" value="XM_066758490.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990865"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="114"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="680"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0246977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="771" mass="84902" checksum="5C0E737648B93732" modified="2025-10-08" version="1">MPESPRISSSAFDLDGPSSTNVNDNLDVLETIDLNDNNGSSIDPWKASEASTSAPSPSRGTSYTTFSHSSSHQELSNDTVNLEETDFSAISTGTPAKTSLPVHWVNNGETPTVLGIAVVDFNHLIGPTVEYAFPPSLQNALSVDENLTKELPFLALPDGAHLSEEDYSYFHCTFSPSNDHSQQHNAETNIPTNQTLFGISCNRQLASSELHHRPSDVTRSMVQKAVVVIASHPIFGVIRDRLGVVTRAYFAQRDFAETKLLEDFYTSLETSLEGKSGEEAIYMGTSLRELVHKFRHRTLVLLKMLMLQKRIMLFGYPVEKLCTYQYSLVSLIPGLLLNLRDSGSPALDQKTSKVRPTSLRTSDRTSLLRFMGLPLRIFSHDAFFQPYMPLQQMDMLAAKSWLVGTTNQIVTQQRECRYDLLVNIDSNTFTFPDPKLERVVGLTPADRRWMDDVVQTVEESWSLSEGERPSYRGSDDDLRARFEEYILSALSSIKYSNYLSQTNPNSPPLSTPSSNIPSSSSINARNSMNQDPNQQGLVTAGSGGTKEGAEAIRDFGDGWVGVFRGTKVYEFWNGSTDETLFDIHEPRHPCEGKVNVVSDLSLRISEGLHDLRLDEQLGPTREALSSAFSAGSSSLFRAFDGVRSEVSNRLREREEAAAAGRARQSVNNNTDPFKNRTQKPFSSDTPTTFTSNTSPAQAQVQTQPVENIRATLGGIGSGIGGFFSSRISSFKNPSPTPTTPKGLRPMSLSSSASTGSLKGMARLNTPERQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP57</accession>
    <name>A0ABR3BP57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_105280</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612384.1">
        <property type="nucleotide sequence ID" value="XM_066759737.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992136"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="140"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="13">
        <location>
            <begin position="955"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="39"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="579"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="858"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="702"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="871"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="885"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0244017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1004" mass="109862" checksum="7F0970FA7611F484" modified="2025-10-08" version="1">MTSFNPAPAQLQAAQDHTYGSMPTPTYMGMVDTGAQWDYVGGRGSSRSREPSASPHRAAAESGIPRSSTHAASISASSSYAPVAGGSGQASSAPHEPTIREEATAVVDRSMRAHQQANGSSSGNGNTQLKKSKVRMVGDWQLNKTLGAGSMGKVKLATNIVTKEKCAVKIIPRYTEANRKGETAKTPEEIEKQRLKDESKEIRTIREAHISLLLHHPYICGMREFISHQNHHYMVFEFIDGGQMLDYIISHGRLRERAARKFARQIGSALNYCHQNSIVHRDLKIENILISKNGNIKLIDFGLSNLYSPSRHLSTFCGSLYFAAPELLNARPYTGPEVDVWSFGIVIYVLVCGKVPFDDQSMPALHAKIKRGLVEYPSWLSAEVKSLLSRMLVTNPAERATLAEVLNHPFMTKGYDGPPDSFLIRREVLRAEEIDMNVVEAMEGFTFGDANTIYHNLHSILTSEDYLHCVATFEAHREKSRTSSPGVSTSDPCDSPKKKRFSGFDLKKRLFKEEKKVEEAPFKEKVRDPTKGYDPLISIYYLAREKIEREKVFGPGFFASSQLSLDTFNASQGYGMAVPNLPPPASTHVMGHDSSRGPDFASEPRPRSDDVPNPIMAHPSADREQSKLTDIPSAVHRRQPSLSQPPLPSSLPAAVERSADEGLTKKFSMLGRGPRPPSAAGPSRSASTKRESVTASPSMPLQEHRRATTIVHNDKSKHERRVSVGSLTNSVSRASGLVRRASQRDRPAATPPDSRWLNAPAEADEYHQVETSVRPSTPHEPEPDSANEPQSYDDVKPSYLKGIFSVSTTSTKPANVLIRDIAMVLDRIGIKHRPIKGGFECVHMPSIDLASVVNGDEASTSLSNVPSHASAARRKPSLRRKGSKVNLNGASSNGVGSRGTSPAPHRVLTGNSSGTVSGGEVAHLSAPPSKNRHQHHAGTVEEDEVDAWALAQSGGAGSSLIMRFEIFVVKVPVLPLHGIQFRRVGGDGWQYQMLAKAILREMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP72</accession>
    <name>A0ABR3BP72_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0246991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612952.1">
        <property type="nucleotide sequence ID" value="XM_066758504.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990879"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="116"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="161"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0246991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="67575" checksum="6A03CC88809B10D2" modified="2025-10-08" version="1">MSNFQFLKSTRTARQKRSVQNNAGRLVHEVTVGPDKNATKNSDGQVVVQISQSGENKCVEGEKDDKALEGEIRKSGCMSTIALMAPTTAAETTPVEQSLGKKSQLMKLYEKELDGIGLEIKDIPGRGRGLVSTKSFKPGSVIIRLPPAVSVLGTSHLTTTCHGCFLTPSEKEILLASGNLSSTTVRVKLRRCNGCKTLHYCSRECQLADWPIHKQECTAFSRLRTMYHRAYPDRVKDEGDARWAGPEGVRAAGRLCWQRRAKIQAHKGKEDGDGWWDKLSLMESHVKKTPEKDVMKLASQVQHLEHYLSAAKDLSPGEDPAVLHPSYMSDYGFDGVGDVLNLCSAIQVNAFTLTSPSLAPVGMSISPLLALANHSCEPNATAVFPKGGRDICLVALNDISPHEEILTSYIDTSTPYHYRQSELLSRYHQWRAVVKLECHWKMRQAKFRYDERGTLDRSYALKILPTLLSHLLSLTPPSSHPTFALLRLHSLLLTPPSTFSELNLATFHLSLAYSGSCLSLPQNHPTQAVILAEWSKLLALDRVHNPEEEGQRGEDELVKRLEMAIIVGRRAVMSAQKGWGGDGGVVGVEMEGLVRGCEGELGLLRARRMGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP82</accession>
    <name>A0ABR3BP82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612965.1">
        <property type="nucleotide sequence ID" value="XM_066758517.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990892"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="10">
        <location>
            <begin position="1173"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="374"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="618"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="767"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="777"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="816"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0247004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1446" mass="157927" checksum="169D7EDBF6E13E86" modified="2025-10-08" version="1">MPDILNQSPATPSSALHATHVLHLPKDRIYIHRYALSAASGASIKDVVEDKLEKFWRDIADRAENGKGMLEAPVAAIAGQIERELWCFTCKDDGIWPPDGINEIQPPLPPLVPLDLLSCPDHSSSYKCLSESSCDVTLNLEGETGKAWGLLANALIETLAWKAGSRIILRDSRVVPFTPPFKPSLYPFTSSSLLLSLLPSPSPTSSSPRYPTATHTLLPLSLPSILVSTALTPTPAQIARLNQTFDTLLGPAWKTGREQRLAREFVFGSGVEAETVSEMQEKGGEEEGWSVFWVPLLKKGPESEEKGVLTVWPVHLALPRLSDASTPNFSLGHNSSATTTPLPPTQLKRFGGREEREQGLMQIAHSLFDFFTSYREPSVPPEGDGGQVDDQDPDHDNEAGLVDNDAEMNETDGEGSNLRETGADARSDIKMEPSPKEGSDIDDLFSSPSPNSTPIVNMSSQSQSNKSPQPQQVQDQSNNVQNGEEDFMSSLVSIQDPNPPSRSQMMGIRDREREREVEVEITEDDFAFFDSPVPEERDGIGMDVDMSMDGGVNQSLLDGAVGHRGETGDEPLTEQGKGILAEEMMKPASPKSAMAGQGDLMLVPLVRNDMEVDGILPEPLPLPPVKTATKESPSSQPLVPLQPPTPPTILEASPKAPEQLASQSSNLTSPSIPVVPAVASNNSLVPLSFQPLPLLPSSHSSSSYPYGNTYGYAPPSPASTPESSILARLASYQTQYQTLVEFEAPSASQDQEATGRLSSKRKSTYADAWFPLSGGNDDGDGEDGEENDMDSQAYTCPPTPISQMEEMATEVESDAGSGGTGGVTGGVTGIDVDSRATGLTGMKDQERESKEDDGEIEWKGMKCIGSEWVVLRDQPGLVQAKKNTESEIGWKVESVWDEAWGTLPSAVSGKKDNVKAKEKLKDKKVKDVNWTKVVQEIITNRALRKSVLDSEGEHEQSAAWMGSLLEGDTLCEVFGSDVLPVNLPQPQVNAASPSTPHIIRLSIAALSYWSQLGLEPQGGKKDVKIFIVCRDSDEALGKMLGEGVKLGWEEERFGKAEFSGIVKGKMEDFGELATGITDQSNGSVNTIVNTIVCLLTPPSQIPLNIYSSPVPNSPNTLFIPVPTPTNPSISFVHEQYLILGHTAYDRLPTLLRPVYVRGEPLRVSEEDEWMQCPAWVLARKEAVKPEFVMTWPVDEYDVLNRWRMWHICYDVVSSSSPGPDAVVVWVGDDRGETGHVRVFEDVGGWKEGMEMICAYGRGIAGRWNLEWRLSVCRAGIMTKEELQAWKDILKGKTWPITLLTSETPSPLNPSDQMTPPKVRAIANIGPSILSDSSTRIIDIALSAQLTILPLPLPLELSSDKGSPQTIYPRRTFLLTTHALNVSQHYTTKYHILSHQAPDGRKDQEDGGIVAEIAEEYHRLGCLARERWEGQGWLDTVRWGKALLEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPG1</accession>
    <name>A0ABR3BPG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104938</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612886.1">
        <property type="nucleotide sequence ID" value="XM_066759399.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991794"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0245802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="92" mass="10571" checksum="8E3856A2F01B63D3" modified="2025-10-08" version="1">MSGRKVMVQPINIIFSHLQKHNRVAIWLYDNNEFRIEAYIIGFDEFMNVVLDDAEEVYDCGAKPGKEVPPRRELGRILLKGDNITLIQPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPU7</accession>
    <name>A0ABR3BPU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,4-dienoyl-CoA reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612808.1">
        <property type="nucleotide sequence ID" value="XM_066759321.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991715"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35091" checksum="9FF93E4A8E989187" modified="2025-10-08" version="1">MTGTGSSGSRALSMAERTAEVYQLRGQVLDGVRARAQEIKNESGRLKGKVGIITGVGPEVGIGTAASKLFAKEGVEHLYLLDYNDEDLPKLVSYLVEHYPGTKVTFVKGDAADHKAVSALVDRTLEEEGHFDFFFANAGISQMAKPAKGKSGNIMSFSRPLKDVEEDEFNEIMRINALGVFVAVKYASIAMVKLCPEKGKSIPGGSIVLTASIAGLKANAGPIPYSASKAAVISMAQTAAYALTGLNIRVNAVCPGLIETDMTKPLFDFVRANGHDSKIGQLNPTLRQGIGYEVAQLALFLVSDESSYVNGQALAVDGGLSASVPYVRSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPZ4</accession>
    <name>A0ABR3BPZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="6">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612315.1">
        <property type="nucleotide sequence ID" value="XM_066759668.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992067"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="7">
        <location>
            <begin position="30"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0243948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="265" mass="28644" checksum="9B93867B5D5001AE" modified="2025-10-08" version="1">MRPTLPSLINILVPVKRSIDYAVKIRVASDGKSVDTNVKHSMNPFDEIAVEEAIRQRDKSGEKVESITALSIGPPKAVDTIRTALAMGADTGIHITTPENTIVEPLSVAHAIKAIIERSEKEGKKFDLVLMGKQAIDDDTGATGGMLAGMLGWGQGSFASKVVIEKGGRIEVTREIDGGLEVVESKIPMVITTDLRLNEPRYASLPNIMKAKKKKIETLKPEDLGLDFTPRLETISVTEPPKRQGGGKVETVQELVAKMKEAGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ52</accession>
    <name>A0ABR3BQ52_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_104355</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613280.1">
        <property type="nucleotide sequence ID" value="XM_066758832.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991211"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="26"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="159"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0247319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="46203" checksum="655849C00269E1CD" modified="2025-10-08" version="1">MADSPSPLPPYNNVWTKRAAEADEWLRQHKVVVSATSASVISTFAGFPLDSLKSRLQSSREKVSIPRLAADVIREEGIGGLWRGFPLPLITISIVRTISFTIYSSTKRILNSTPLPSEPPKADHKPTDDARPSNKDGSSRKTPWINIQLGWFSGDNAKDIGITSFLAGAVSGAVVCVGSAPFELVKVRRQLEYQIYRDSHPELFCNPSAATAGSGYKVAVPGVPPTASFTPPTTLQAVKLIVNSNGPLGLYIGWRLHFVRDMLGTALYFAEYDVMRYYLGRQKTKIRENGEGGGFGSDVQGDVPDWAKAWLPKQAVPFLCGSVAGVSSWALIYPVDTKAQQRALSRLTPRTPAEQFHRLVRGTDKDNPKPLLSGITRLYRGLGISMIRSMLTHGLLWTLVDAAGSYIDTKPCERYFGVDVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQF5</accession>
    <name>A0ABR3BQF5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104459</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613384.1">
        <property type="nucleotide sequence ID" value="XM_066758936.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991315"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="10">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0247423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="123" mass="13343" checksum="C9AF3027046B3DA7" modified="2025-10-08" version="1">MSAGQTYYEFYRGSSIGTALTDALDELITQGDIPPQLAMRVLQQFDKSLTECLQKGVKNKTTIKGHLSTYRLCDDVWTFVVKDPQFKMEGVGAGSEMVTGSKIKIVACKSGDAADGKKAGARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQH0</accession>
    <name>A0ABR3BQH0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612864.1">
        <property type="nucleotide sequence ID" value="XM_066759377.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991772"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="131" mass="15292" checksum="0BF330CF15053F85" modified="2025-10-08" version="1">MSLGSSERLISGPSLGFGLPASINKREAGRYGLELLLLIIHSLSYILYLAQLWATMVSLPILQFLDLNYLRVYPFWSYYIVTAYLLFQRSIEGVVYHSYIHRTRSDPNQRHLRQFYTKPDLHIHFPSQSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQR0</accession>
    <name>A0ABR3BQR0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612570.1">
        <property type="nucleotide sequence ID" value="XM_066759083.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991474"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="775"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="993" mass="109606" checksum="338F17E45D4C6700" modified="2025-10-08" version="1">MGPLRRQPAMFDLHGASRTVSVKCDKWDKDPWEQKEANHGTLNRLSTTALREVEVQKRIKEVRQGDKYPKASPMAKRSEPLLRRPTRSTDSPDTTTIVLEPRSRSFASARFEKTVMTYDHVPAISPCSDFGEGLSWVLGMSKPPQRFHASEYPESAYSTERPDLSVSEQPASHPMVREYTSMGWNGENIGNRFDSGKSLEELPLINANGLEGTKKGNSISPWCQVSRKRSQASPSSNSIRDHETRTHTPLHTLKGSKFKSCPGGLLLDPGGPSWPSSASFSPSSASPSPPSSSPSGNSFISSSMFNQSIRILTATTPQTRPRMTFLANASDISILAPSTIGIGCSSSVGTGRSGSLPESLEAECIDLTETGRRIWHANGSKGDKQHSWMSRMRTVGLETVEIIAEEIPSTQPLESDPVYLNSYSIPPVHAQSTLHTRPPVQEPKLKRAHTYANLKDVWKLASFPGGLIIAQPDEEPVEQENQALSPRVLKSPAVIHPPSLGSPIDILPLPVSSTIAPNSITVHNPPTSHSHSPVRSVPIYSPPDADEEHSHVCSFSSPQTGNIRKIRLSPFQATRNSLRGMLSKSFKSRSLAHAFDNAKQNSHQRGSSLKSKISGPLLVRSVRDEMDRRKSDKEWREEVLKDVVGRTLSSQFKLLEETAKQQRESLLVKDKTDQKASLFGTGLKTRIPIPETLSRAVSIKKKKDPTNADSCENKMKMNSGTRPNMESSLSLRMVTDETFNPKAEGLTSGHLGDPIIREDFKYRTPPLRLSGNGHPTSTSLLSPWSPTSPKSGETLSQSIDPSIIINDAIPCLDESPKSKRHGRTSSSPPPKPGRSKSWRVSRRSSILKLFKSKDSKHQNTSQDPLIPKKTASGTFTLTGSIRSSFLAITKHHIQTAEQEERSKCPRPPCVTPFFTLPLRTSIHQHIDLYRPLSRSRSSFELPSNLSPAKPLLDTLVARDDALGFLEGRNKMEQTVEVDIVKVLEWRKEVAKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQS4</accession>
    <name>A0ABR3BQS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613493.1">
        <property type="nucleotide sequence ID" value="XM_066758091.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990456"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9653" checksum="7050202EEF8CD2B6" modified="2025-10-08" version="1">MMKDYLTTPSPKRRGDKPFEVLITGAGVADLTAAYALRQSRVYQEGKLVIRLVEKRSEKAWEGRMGFPMHLTKAARNALDELLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQU7</accession>
    <name>A0ABR3BQU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613523.1">
        <property type="nucleotide sequence ID" value="XM_066758121.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990490"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="7">
        <location>
            <begin position="116"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="6">
        <location>
            <begin position="321"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="629" mass="68894" checksum="1F791825DDBD779A" modified="2025-10-08" version="1">MYSGSSTSALTRVATARIALRRSTVASRRNVTSPTITAEDKNLIPIRTNLRGSALLNTPRLNKGAGFTREERQIFGLEGFLPYDVHSLEKQCLRAYNQLCKQPSVILKHAFLASLRDQNQVLFYRLMQDRLKELLGVLYTPGAAEAVAGYSSLFRRPVGCYISFPNQDGMRAQLEGHLSDVNRTADVAYDSNKPDDAIDLVVVTDAEAILGIGDQGVGGITISTSKAALYTLGAGINPNRILPVVLDCGTDNHALFSDPLYMGWKRTRIRGKNYDQFIDRFISNCRELFPNAIIHFEDFGMANAYRLMEKYKNIPMFNDDIQGTGAVALAALLSAIKVAGSRLSDQRIVIYGAGSAGMGIADQIKDGLMILEGLNKEEAARRFWCVDRNGLLVESMGNGLRHSQMPYARPDAEVEHWTKADEDKNGIWLMDVIKNVKPTVLIGTSTHSRAFSEELVREMGKHVERPIIFPMSNPTALCEVDPADALAWTENRALVATGSPFPPVKLGNGKEYVVAQTNNALIYPALGLGAILARSKTISNSMLMAGVNSLASLSPALSNPEASLLPDLADVRKVSVDVAAAVVRQAVEDGNAYDENTLMYAKGKGDVSLEDYIRGRMWDAVYRPLELVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQY1</accession>
    <name>A0ABR3BQY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612378.1">
        <property type="nucleotide sequence ID" value="XM_066759731.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992130"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0244011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="39856" checksum="D7B1CB788AB36290" modified="2025-10-08" version="1">MKSSSDAGVDVYIASSSPLLVYTHSRNGALGSAWFQNENGSSKCEGSSRFAVQIDSLYFSDIAFYWSSSTSYSVQAGLDGSLQTCSTSSGVATLTSSFGSHSARLECVGDGSSSEFELIGIKLKTQVVPSGSPSNSTLDDASSEVTYSGFSSISSSHSTVPAIKAGSFYQNTVSYTSNADASASFTFQGSAIYIFGMTGPEFGCFSISIDSTTIGVYNASTTVETYSTLLFFTTYLDASKEHKVKITNENDGMLLALDYFVAVQAGTSSGSGNIISGSTTTSSTKGSTATAVFGDGSTNGNQGSGDDSTAAIIGGILGSLGALFVVWFCWAYWRWKKTGGQGGLLNAVCGGRRKKPAPPPPSKPKQYPLWPMVLSRPKYAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR00</accession>
    <name>A0ABR3BR00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613285.1">
        <property type="nucleotide sequence ID" value="XM_066758837.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991216"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="855"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="101410" checksum="A1ADB9992D9B469D" modified="2025-10-08" version="1">MAPSGLIISKLGIQATASDTHVRGLICLKISLPRESAGRPGARWVLFNSTPAALLSQPTIHPLPLSLPSTQSPHLRIASTLLSLPHSTSYPPTPSQPSILGGKPYIDVSSTTGKVFVVVDSLGGSGRRGSLKGGSFKGKNNSSGNTEWERKDWLIVVEFQQVLENSIEGGIYKVLLPLPRCLDNVIRFQILSPSVSASSMNQVSVLTEPKMLPLPGSTFDSDPTPYGRELINGKGKDVMREEGWEDGEDLEDEDYESDDQGSSWLEGRFQSTDILRLEWSFTSTMIDPTTPLLLISPKWDKNRPSMELSYTGVAPGSDTVVSLEVDVPEGWAWAEFIIKSEGLAYWRGVDGEFESEEKEDPDRTAEYRDDDSFATVRPQESAHLHRRSRTSQSIPSSSNAAGPSTATYLPPTSGSGSSISLMRQTLPIAGEAMDDFSFEMSSEQSPAPKRPNTPLGSRVSLIPTSKPSTPSKRGKPSASIPETKFVKQGKLFDLYFHEHGDRAITLHGVLVPISNLTLVSQQLPCPIPLVVLHNGPGQCNIQCSNALYQDQTLSTSEPRLISVPSTNAFFWADDSLSNRKRDKENGRMKGDARIRLRRDIWGVVSMFVLFSFPRRGDEVGFTLYPSNPDTNEYDNDTKGRTIRVIQTSMDGQLIPRCLHRWQDGKTEVRVGKKEGRNSGLVEIILEMVGQEFSLPTFEDAEGMGLVELCGEGWEVVKPSIQTTLTPSSNDTYSYSLSTPCSISIQPSSTVSPISTTSRARTLFSFSTFFNLFMLWLLLSMGSQIQRLRNEVSYVAGEARDLRIYGYNPSPGGAGEGREGEYLDRTLKDGEEEEVKGESAVTLGSTHQIPLDDPSSHSSSEELLSGAPPQAASLHLAAPNALAPHEQHHLWAGWDKLVMHPTVKSLAKSMAWLWHAVIWLVVPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR13</accession>
    <name>A0ABR3BR13_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103713</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613597.1">
        <property type="nucleotide sequence ID" value="XM_066758195.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990569"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="60"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="478" mass="51980" checksum="3D338DB359DDE951" modified="2025-10-08" version="1">MGVDLEMYGKDPTTTAVVESTTFSAFDSKLDDDVPKFSDPERDAVFGERKEGQVDYRSVGMLKSIVLMIKLVLALGVLALPNVLLTVGAVPGVIIIIVVAILTTWCGHVVGTFKRNHPEVYSMDGVGYVLAGTWGREIFSFTYPLFMIFLCGSGYITLSIAFNAITDHATCTVVWAVIAMIVTFGLASLQTLGKVSILGWIGFSSIMTAILIITIAVGVQDRPESAPSTGPWEKKIHAFRTDVTFLEAMGAVSTVVFAFCGTPAYFNVIGEMREPKRFNQALYCAQSVNTAVYLTIGIVVYYYCGQYLSNPALGSAGILIKKIAYGVALPGLFVGCILYTHVGAKMVFVRVLRGSEHLTAHSFIHWAVWLGTVGTCVTISFILAQSIPFFGDFVSLIGATLGTFLGFISSGWMWLYDNWRHRKTDTSLRFRSLVVFNVLLVLVGIFIVITGTWATAVSINDSYKNGTISSPFSCADNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRD8</accession>
    <name>A0ABR3BRD8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I308_103832</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613715.1">
        <property type="nucleotide sequence ID" value="XM_066758313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990688"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="320"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="169"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL0247754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="785" mass="84643" checksum="E9EBD0979E490433" modified="2025-10-08" version="1">MPRDTYSSNPVISSPVYHNRSARSSSFSFEAWRYAPSPSSEELPQELPAGAMPAAADTFSVRQSSLYSQPPSMSSSPRMNSSFSRRDNQLEKDDLFGSVPTHFNSSTRLAYEAGPYMTPQPLSYGRSRSKEPTRSCIPTNPTKRRLLFFGVPILLVIVAAAIIGGVVGSQKHHSSDNGSSSGAIPSGTSGTSGGGGSNSTSDTNGTTWNTFVQPGSGGDGSTVTTDLGVNFTYLNAFGGTWAQNPYDPYSVSGQAQSWSPSLLEDWVWGEHIVRGVNIGGWLVTEPFIVPGLYEKYQTSTPKAIDEYTLSQAMGDNLATEMEEHYKTFITEEDFALIAGAGLNYVRIALGYWAVEMIDGEPYLAKVSWNYFLKAIDWARKYGLRLLIDFHALPGSQNGWNHSGKTGSVNWLYGVMGVANAQRSLETLRSIVEYISQDGIKQVVPMIGLVNEVQGKIVGQDVLTAFYYQAYELIRGISGYGAGNGPIILLHEGFYGIAAWNGFLAGADRIGLDQHPYLAFPVTQISDNHTVQAHTVCGWGGGTNDTSTSYGIVIGGEWSNAINDCGYWLNGVDSTPQFDLTGTGNCTGVEEWFDYSDETKQSIMDYTLANMDALQNYFFWTWKIGNSTVKGYPTSPMWHYKLGLEQGWMPKDPRVAGGHCQNIGVGGNQFAGTYPASAVGSFPTDVATPTIDPTQVASHSVWPPTALGPSPSYSAAQITLFPTLTQTGTRNVLATPTHPSNVTLGGGWANAADVTGAWVRVAGCHYPDEYDANTAAVPTAQCTGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRT4</accession>
    <name>A0ABR3BRT4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SLY1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613847.1">
        <property type="nucleotide sequence ID" value="XM_066758445.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990820"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="77400" checksum="6B7B2BDB51962879" modified="2025-10-08" version="1">MTRPSLLEAQTRALLTLLNLNTPAPGGLEGPPPLVWKVLILDEASQDVLATSLRVQDLREQGVTLHMQLHSPRPPLPDVPAVYFVAPSRANIRRIAADLSPPLYSACHLAFTSALPRALLEELASLILANDPAGQTAQLIASVTDQFLDFVVPAPNMFSLLPRRERMHDADGEKAKKAREEWVEGRASYVVLNDPRATEVDIEEEVGRIASGLFSVITTMNMIPIIRCPRGNAAEMVARRLDARLRDHIASTSSRTRDAYTVDALQRPLLVIMDRNIDLVPMLSHSWTYQALVSDVLDMKLNRVTVSSPENGRLTKKSYDIDSKDFFWAKNAGNPFPAVAEDIDTDLSKYKTDAAEITRSTGISDVNDVSQIDFTSNTANLKTAITALPELTARKQILDTHMNIATALLQSIKERGLDNLFQIEETAGKQTKATILAVLNGATDEPGQTAAPSPLDQLRLVIIYFLSTQDGALSKDDLKELENVLREHGADTRALGYVKKVRDIHRMSTLAVQPAAAPQTLSGSGGEWTRGFSALGNRITDRLREGGIPTVGLDNLISGVKSFLPARKDLTLTRLVEALMDPASASSQALQDTDDYLFFDPKTSRARPGGGAAGAAGYGAGTGGAAGTGTGGARNQFSEAVVFVVGGGGYVEYGNLMDWANRSGGGGARDGGGGGGGGVGVGAGAGAGAGAGGQGVSGQGGRRITYGSTEILNPERFLKSLEELGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS82</accession>
    <name>A0ABR3BS82_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613997.1">
        <property type="nucleotide sequence ID" value="XM_066757613.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989968"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="420" mass="47715" checksum="9010D5FD0080F3A5" modified="2025-10-08" version="1">MAFSALLSLTGLLFIFWHTWHYDRWRCLLYTKDNWFRATMCHILLLSVMGLQVYTWIDVHVLYSEYWIYYPPLKETIVTPYQLYSQTHYDLFKTSLYFITIAWGFLQGVHLEEFLYWGYLIKSINTPGGPQTSWLRSGFFKAWIGLFICSFALLIASVHIENTNLDMIRAYLFCVGSSLSILLAFASVALCLIFPSFLKNVRRLGANAEVLERLHFFSEMNEIRTACRLVYSICFLIISADAFTAEKRVNKSQFWSDALYLSGQLGLFCATCLSVVVLIPRNMASESLPSSNQDVQPIVPYNRPPPEGYSAKQFMELGERLNVGDEAKAIGLVINPRGFEMQVSPPIDNHDDSSSGYSGRTKVDAPFAEVAGKTRVARLSELSGLPSVVQRFKSPFDIAEHKVKGPTQVFVTTSHTIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS91</accession>
    <name>A0ABR3BS91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="4">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HCR1</name>
        <name evidence="6" type="ORF">I308_103115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614000.1">
        <property type="nucleotide sequence ID" value="XM_066757616.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989971"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0249813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="248" mass="27104" checksum="61FC7C4CEDE2D080" modified="2025-10-08" version="1">MSDDDWDVDETVAPAAPAVALPPKVPAKKWADEDAEDNDNDDDWDKSDDEKPQAIKTATVAPAKKKGTLKQKLAEKEKLAREAKAKGVDDDDDLMYTMTEQERRRLAREKEQEADLAVASELMGAVDLGDEGDALKSVLSARPSTKNDFAELSKNIYTSIIKKHESNPLYSQFVEQLAKDISAALTAVQTRKVSSALSVLGNTKQQEERDKASGKKKAASKPKLGGTKVSSKVDTEAYDDVLGDDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSA6</accession>
    <name>A0ABR3BSA6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614033.1">
        <property type="nucleotide sequence ID" value="XM_066757649.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990004"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="838"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="780"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="932" mass="97843" checksum="34318D7E586C7959" modified="2025-10-08" version="1">MAASLPQDAPNPNAPTFRPSPTRAITLGGTPFQYKTRAASQPAGERFPIYSTPSSGRGTPGANGNGNGNTDGTAHGNGYGVIGGTRGGGRFGNALAGGGGGGTATRASSFSAGERHEPRNMAPGRTLSSHTEELVPSRSQSTSPFPTFSPTSTPSTSPAALRQHPLPHSPPKAANSVSRSRSQSLATGVRPSAMDRPWMGPLTKPDVASVDTWGSPEPSNMSPFTRGLSSLAGGGGGGGGGHTHPDARRFQDPTYTSARAAWADSHTQSTQSALTSSVAKALGGYPSHSLGLGYNDPSPGAGGGSRSGTSSRRHSVSVVGGPGGRRELVFAEGGGMTPLGSAGFGAFSPRGGLFGFENELGNALNLDIDLGRETKKRQDSFHHGSLPKFEFDGGMPGARGAWDEAAFPSFGTPARGRVALPPSSGGNQPQPFHIQHERAPSTEESRRFPQASFDMPPPPLAIRRSSIQAAAAMSQGPLGPVGTGIPRNIPISNMSIGPGPGPIGSPPTHSNMPPSFGGSLSGNAPAAPIRQPYQNPTAPGAVQQGFRPQYGYFSGQPLQQQQQQQQQPQHQQQQQVRSGLGQIPLQSAYKPINIPPNQPYAFSPSSSPAFTQPPPQLSSQPPPPTTHAPASPSFSSLSLSDLGKGLPLSSLPPTTPLYIVTFKAGRRDVYYCPDPTLLISNGDLVIVEADRGSDLGTIVCDQLTPVEIREWQERQATKALLSGAREHQPPGMAVGAAAAAAGGGGQAAGENVSNAGVLGHTRNLSGSASGQPQPPPAPQPQHTQQQQQQQQSPQPFLQGMELASLDIDSLLAGVGPGGQMEVVGTAVRGPLAKEIMPKRIFAKSSQGAEEQQRMREKIQDEYDAMMICREKVAQRGLPMQIVDAEYQWDRRKLTFYFKADKRVDFRDLTKENFRIFKSRIWMSMVSKDDPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSB1</accession>
    <name>A0ABR3BSB1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612888.1">
        <property type="nucleotide sequence ID" value="XM_066759401.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991796"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0245804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="254" mass="28084" checksum="0C00171158C1E601" modified="2025-10-08" version="1">MPHASASLPTGSMQVYNLREPPPCRNDAVTPALFIPVHAIHDRLKHRKVRVIGQILHFNNRKSILIITSHPPAATATPTQSPTLLADVSIPLLANSPSARDVTDILGTAVFSRVSKSFSPPESEEDRKMVRMKGLVGREMVSMRRGEWVSLVGWLEDGKDAVRKIQTFGPYAPPPLLILEVIHISNSRPFPNPIPKLRGEMVGWNGQLTAIGPNTPKATMKGTAKQTAERFGAEQEECWDEITPKPKKMKQISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSF2</accession>
    <name>A0ABR3BSF2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614076.1">
        <property type="nucleotide sequence ID" value="XM_066757692.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990048"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="66" mass="7707" checksum="05A32D4401F95E49" modified="2025-10-08" version="1">MISSRNTTLKVYTIGGHRSAVRTRLSRPVTARRRGSSREHTRQQEPQLRLTHGKAAVEYWYKRLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSN2</accession>
    <name>A0ABR3BSN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613644.1">
        <property type="nucleotide sequence ID" value="XM_066758242.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990617"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="380"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="631" mass="70159" checksum="ECA1A9EE1B675E5A" modified="2025-10-08" version="1">MSRPQAAPRPGTAKPQGAAPPQNMPRRNPGTVPGLARTASSLRQGSSLSSLPAHLRNLSAPPVPSPLGKGTPARQLKQSLPVRTSKTTERHVFLPEDPQLAPIPRSPLETPQLATPPRRGSATSTLGPRQQHDERSDAEKMTRREREENRLPRLTAYATAEGYKLKTLQAFLKREHGVSVIYNLPLLPGYGATTKVRSSPVVKSPGGVSLMERMTMAEEQGYNDSYFPREDPAELTPAEYILSSSPSGGDGVGTDLDVLAQDGEREREMRERQGENEPQGEGAQQTSSDMSKPEAESEEPEHHPHHDPGTHLSPDHPGYLEHTPSTALTPMDLPPHHPHHHHASSIQTQEAYTLPPPSIGPLKPRRRKSHASLNNVAEAIFFSYGVSVFFGFNETEEKEIMEDAETAGAWIRGLNEDDWEVEEFHYVHDPDAENPRIYNDMFTFKSRSHLFKLSLAHAIAQSTKLSIYESVMQETLSLTASFPKELSITGHLQLTRREALKMTGRLFKLRMDVNLSGGILDTPELFWSEASLFPLYEAVHEYLEIGPRIQVLNDRLAVAGDLLEIIHEYIEERATHRLTWIIIWLIVVACFVELGEVIARMVFHAIPREQGEFLLLKAPQLLIAGAGQSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSU6</accession>
    <name>A0ABR3BSU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614207.1">
        <property type="nucleotide sequence ID" value="XM_066757823.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990179"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039588">
        <property type="entry name" value="FBXO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008">
        <property type="entry name" value="F-BOX ONLY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008:SF4">
        <property type="entry name" value="F-BOX ONLY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="695" mass="75111" checksum="CCDB237C62022702" modified="2025-10-08" version="1">MPKRQRPPSSSGPPAKRSIATRHSIADLFPLQEIFLRILSFLSANELAKVQGVSKYWQIMSLDPQLWKRLYLAKYPHPHQSRLIQTPESPKTTPMTVAGSLRPIARLPSRAFPPPSPSRTSSASASLPGTPGKLEEVKHDNRAEAFGSLDMVGQYVRNDGVDWKMMLRLGTNWSNGNVLSQTTMSLPPSPSPSVHPSEVLPPSVPSSVPPTPHTQHLALFPSFIFTASPDSPLVYCYPSPASHTNSPIGIIPPPPGWSSPSRPDNVTAICADQAVAFPEEGDGERNLPARMAVFYQSGGFVVLSVRLSSSSSNRGVTWVRDAVCPGQSRPPSIRRRMYAQDRGDPIVYASMYSRLLVACSKAFHLSVFDLQSGQLPRRITTMRSDVSFHPATLTLLPSFPGDKDSGKLVADHGTSQSFQVALTYSTPVYPSSWTIAVQEFSILLPPISSLSTPSVSRGPTYHVSPRSTAGEPIWPRKIRPAVGVKGAAKSVGTDGRWCVLAGEGNRVEVFSLPSSSSPNSTDCDDGIIKHSQTLVTHSSIIASVALASGRCVSGCKDGKVLVWELDDDAEAGNSDDGGGGDGGRGERGKMDKTMGYVEVRKGGRRSTWKGASGPYCSQDNAVDKEEGARHEGLPHPQSISSAARTLFLPQPPKTQNQIEERDGRKEIRCLAFDEEKIVGVVRGGKEEAIKVWNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSV3</accession>
    <name>A0ABR3BSV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103836</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613719.1">
        <property type="nucleotide sequence ID" value="XM_066758317.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990692"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="300"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0247758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="392" mass="43802" checksum="FE197733D24A2960" modified="2025-10-08" version="1">MPATDQTTLFKSILTTQQSSLATSTRSKSPAPISRKGKAKEGEDEGEFLKEAYRIHTHLRSLQQLLASVRKAYLSTVEPPPLSRRPKEPQRNVSGDAKVEEEWTRWEKVKYLTDKERDEIDLRARMILRRCQERIGILEVTEQKRKSKVISSAKPTSTFSSLLPSLASSSISNFEPILSAHHASILWTLNEFLARLTGAVSDLQAERVKRREERTKTLGAGATLEAQQLGLVSHARKRSIPEGVITDVHDPAFSHTIGKDFSDPHLSHGLGIIDPSAPAIDQLLSQEQIRTFESENNALLEHMSSTLSSVLSAEASLLEISQLQSELIRHLAQQTEMVEQLYEDAVGSVAEVKRANEQLTKARERGKDGRLFLLIFILGASFSLLFLDWYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSW8</accession>
    <name>A0ABR3BSW8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613734.1">
        <property type="nucleotide sequence ID" value="XM_066758332.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990707"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF14">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY PROTEIN 7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047011466" description="NAD(P)-binding protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="40792" checksum="459D06013123DC33" modified="2025-10-08" version="1">MPHLPLWILPLTIPILYLLKSRPLPSRETVILPDEERVLLLGASSGVGKDLALAYARRGAKVFLLARRAEVLEEVRRECEEAAAKAGKKAEVLVFRGDLTKVADLVSAREMIVKAWSGVDTVHILAGLPSTSLLMDLAGVSLDRSNPSTASPSGAPLAFSSKGESKNLGPTLEGLERVEKEARAVAEVNYLGTVLALSCFLPLLASSSRSPALHHLSSVAATVPAPHRVIYAATKSAGLMAVESCRVECEGCGVRFFSFCPGTIDNEFRLKTATSQTGGRDETKLPIKHAWEGLLLQPEIVTKTILHHLSLSPKPQPLIPYPPFNFFRALDAPPKHLVHMPFMYRLAMFVRDTPLGWRYIEPAARRKYGLIGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTA1</accession>
    <name>A0ABR3BTA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase III subunit RPC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614366.1">
        <property type="nucleotide sequence ID" value="XM_066757982.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990343"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="49185" checksum="D059F415573BD340" modified="2025-10-08" version="1">MSNQPPPALVSAAMQTNRSTTVSETSAPSARSTPGPSAGPSGEGAPAGGIQRMKFKPKVPIRRVKTEAETPSEPALVTQPPARGGINGRGRGGGTRGRGRGGAVVSTSIAAGVFGGPRPAASSSRRFTAAAPALRTTDYPSDAEVYSDHSEEDGFPSMRPIDIDMVSTMSESAPTSLYRDRKLTQGKAKGEKDKKDVKTQAAKKKNKEKNEDSSRGGVKDEPMSPSQRERDDDAMMPGDEEQDRDERGRRVRNFMQTGGIDEPEVEEVNAAQAVDLSESESEDEEDNLKGDFISIDGNDAPENKLFIFQFPHLFPKFNPAGPVDLTNPDGDMKPDIKPTAAQLRAKKNVMEPTPEGRVGTMVVMKSGKVKIVMGKDIVMNVNPGVPATFVQQLVHLEAKQKSAIVLGDVHKNYVVTPDIDLLLQDLYSNGGQTPGDKEVEARVKALRMRGLVKMEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTM6</accession>
    <name>A0ABR3BTM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 6"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614487.1">
        <property type="nucleotide sequence ID" value="XM_066757018.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989330"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="108" mass="11611" checksum="53ECEF4A64E16287" modified="2025-10-08" version="1">MGVTVETISAGDGKTFPRPGDSVTIHYVGTLLDGSKFDSSRDRGTPFVCRIGQGQVIRGWDEGVPKLSIGEKANLICTPDYAYGARGFPPVIPPNSTLKFEVELLKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTQ6</accession>
    <name>A0ABR3BTQ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Methenyltetrahydrofolate cyclohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_104443</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613368.1">
        <property type="nucleotide sequence ID" value="XM_066758920.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991299"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="13">
        <location>
            <begin position="78"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="14">
        <location>
            <begin position="226"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0247407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1021" mass="108993" checksum="5F42CA6B84B6F921" modified="2025-10-08" version="1">MRISRPLGQLNLYSRTSPRNPFPVPLARVISAPPRQFLQSPRLRVNAPLASRTFSISSTHLAKMSADVEMASQAAKIIDGNAIAKEIRTSISQAITDLHASNPTFHQPHLVIFQLGSSAASSTYIRMKLKAAEESGMTVEHIKIPSDEESGALKGTGVKRVLEAVKKANQDEKVSGILVQLPLEGAGKTEEKAVVDSVDVTKDVDGFHPENIGLLSSRISEPFFTPCTPAGAIKLIESTGFKLAGANVVVLGRSDIVGTPVCALLRKKDATVTQCHSRTKNIEQIIGQADVVVAAIGQAEFVRGEWLKPGAIVIDVGTNYIPDASKKSGQRLVGDVHFESASKVASYITPVPGGVGPMTVAMLMSNTFEAAKRQWSSRRAKHLIPLPLEIKEKVPSDIEIAVAQTPKPVAEIADEIGVHPDEVESYGRYKAKIELSVLDRLKARKDGKYIVVAGITPTPLGEGKSTTTIGLAQALGAHLQKTAIACVRQPSQGPTFGIKGGAAGGGYSQVIPMTEFNLHLTGDIHAITAANNLLAAAIDARMFHEATQTDKGLFSRLCPAKKGVRTFSKPMIARLHKLGINKTNPSDLTEEEAARFARLDIDPTTLTWNRVLDTNDRYLRQITVGQAPTEKGLERKTAFDIAVASECMAVLALSKDLADMRARLGRMVVASSKAGEPITAEDIGCAGAMAVLMKDAIKPTIMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLAGVEEGDDESRNGYVITEAGFGADIGMEKFCNIKTRVSGLKPNAVVLVATIRALKMHGGGPAVTPGKPLDQVYVEENLELLEKGCTNLGKHIENAKKFGLKVVVAINKFSNDTAAEMALVQEYALKVGADYAVPADHWARGGAGAVDLANAVIEACSTPSTFDFLYDLNQPLTKKIEIIAKEMYGADGISLSPEAQAEIDRYEKQGYGGLPICMAKTALSLSDDPSKKGVPTGFTLPIRNVRLSAGASFVYPLVGDMSTMPGLTTRPGFYDIDLNPDTGDIEGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTR5</accession>
    <name>A0ABR3BTR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_102517</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614531.1">
        <property type="nucleotide sequence ID" value="XM_066757062.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989374"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="11">
        <location>
            <begin position="331"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="423"/>
            <end position="429"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0250344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="696" mass="76402" checksum="9F81ED5EB6870B19" modified="2025-10-08" version="1">MGRRSKNKQGPPAPLPGSIPEKAESRRQKTKKRAPSAVTNEVASRGKAIRGPGASVAGGRKKGVIVGKTGKVIRGPKGKKVDEVDEDSDLDEALQPGEYSSDEEEEVEQPKTKKSKKATKNESEDEEELARGPAKELVFSDSEEGEEDDDNLNDDDEALPKGLHNFDLDAAPPSDDDEEDLEMADEFDMDEDEFGSEERDEEDSAFASSGDEDADMAEEEDVQAGEDEEDGIQTNLEDDLEETYTLPAVDNGGEEEEHEHGTSLREVENRMRWLVGVVLNKEEKVSKGVPGKSRSDHMLQLQHDIATYFGYNTFLVGKLMKLFAADEALAFFESNESPRPVTIRANTLRTRRRDLAQALINRGVTLEPIGKWSKVGLQVFESPVPIGATPEYLAGHYMLQAASSFLPVIALAPQPNERVLDMASAPGGKTTYISALLQNTGIVFANDSNKARTKSLTANVHRMGCKNVVVCNYDAREFPKVMGGFDRVLLDAPCSGTGVISKDASVKVNKTERDFQLLAHLQKQLILCAIDSVNPNSPTGGYVVYSTCSVTVDENESVVDYALRKRPNVKLVETGLDFGVHGFKSFEGKNFHSSVSLTRRFYPHKHNMDGFFVAKFKVEPRKKLTKAPVAEEDDSPQMIINEEGEIVPEETAKFDAAEDEELIRESKRKALKKKGIKVSMKGGENGSKGKGKAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTS4</accession>
    <name>A0ABR3BTS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PEX18/PEX21 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_102523</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614537.1">
        <property type="nucleotide sequence ID" value="XM_066757068.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989380"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056940">
        <property type="entry name" value="PEX18_PEX21_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25098">
        <property type="entry name" value="PEX18_PEX21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PEX18/PEX21 C-terminal" evidence="11">
        <location>
            <begin position="214"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="673"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="707"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0250350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="799" mass="88136" checksum="5BCBF79BF18C2196" modified="2025-10-08" version="1">MSAFLSGASVQCGPTSALKNISDRINVDRSLQQDRLAYTLNASGPSSKQPFRDQFAQQPVARQPKPVPGPPSAFDLSSLRQQLSPVPSASHVSDWASDFIPPTGPTSSRHAHFVAPTKSGWQEEFSQHVAAASPLGAARSQKHQYNANLAPWEVPTSQYPLQRSALMRPSFPLHTIPTSEASLPLPRPDTQTAAPITRHEEQIDQPIGPETLPLDDSQELLARTARSFINNLETQSDILSANPKLAQSKFMRLVRGLGDEEVVVKEGQEVKGEEVGEGATFIERNIVGENWAEGFAKQNGKSARQEASTLPEAEYLERRSPYPRGQKVYPALNSWFSTLPPHTSIPPLTAPQAAPLASNSNALWDQQYRDQEALLQSSESHTSERRKSVHFGKHSASQERSGVPNTLEEALSSRGNVPGAGRGWSEQGLTHDFDEDVFAMFNGQLRRSQENLEGGVGKQEGWSKLQSDWEEFQRAEPGVSHVRGMGTSDQTERYLFQTRNPYSSDAEELYLEVPRGSPTLKGILELEAEVQKDPISHEAWYALGLKQQENEREDQAILALSKVIQLDPQYRPAYLALAVSYTNEGENEAACTMLENWIRMKDNKDAIGSDGQKGRGRDKLIGSLIEIARQTPHEIDADVQVALGVLFNMSGGEDYSKAEDCFLAALAVRPEDWLLYNRLGATLANSGRSSEAIQYYHQALTLHPSFVRALFNLGIAYMNLGQYQAAAQSILDALRLQHSGASEAYPYGQNGGGAKGVTSETLWNNLKSACFHMNRHDLVQIVEKRDLSGLPLRFVDEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU33</accession>
    <name>A0ABR3BU33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614383.1">
        <property type="nucleotide sequence ID" value="XM_066757999.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990360"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="6">
        <location>
            <begin position="26"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="294" mass="33112" checksum="E957519FFEDD3ECE" modified="2025-10-08" version="1">MDKEQVSFQEEKPRPTLFTRLRHSPYVLLPILATTVWFSGLTAMMLLWVCAGKPRYGPKVASIAFISDIGGVNEGLFLGICVVVIILYFSSVCVIRWLRWKGRLPENLGRKERIYSYLVILFCFVGCTGLFVLAKYNCYDYPTIHWAGTLVFIIGVASSAIFQTLEVRQLNKEHGERKHLKRNSYFKLAIVAGDIILAAAFGSTYMYCHGQAIATYSHTASECDDVSSKAAILEWSIAYGLNLYFLTLAADLWPAWKSNKRFLERAEVPGKEGQNEVSDLRRSGVWPPCIVQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU99</accession>
    <name>A0ABR3BU99_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the YPI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614611.1">
        <property type="nucleotide sequence ID" value="XM_066757142.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989454"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="170" mass="18853" checksum="3CDC16BAC15175EE" modified="2025-10-08" version="1">MSLAQRSPPTRTSTATLTQTQTTPTDTPPQTVLQLRAGPSTERRVVWTEETVDNEGLGKKKSKICCIYHKPRAFDESSSDESSSDESSSETDRRPSRGSKDHRHRLKGDSNVEDEQSSESDGGAGDGRARPLRKPHRHHHSNKCDHSDHAHKPNKYDVQPKGTGKSKETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV91</accession>
    <name>A0ABR3BV91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615028.1">
        <property type="nucleotide sequence ID" value="XM_066756251.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988555"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="31"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="441" mass="46861" checksum="AA2B2FB49D926324" modified="2025-10-08" version="1">MAEFHFLNKTQPPQVTKLNLPENTSCVLLKKRNIVVKPKPMPILQPDGVLVKVVATGICGSDLHNYLAGGVGGRPVTEPIVMGHESSGEVIAVGDLVKTHKVGDRVAIEPGLPCRRCINCKEGKVNICLSMHYCGAPGSVGSLSRYFALPADMAPHIPDHLSWEEAGCIQPLAVGIQVGKRVDLGPHKTVAIFGCGPIGLISAAVAHAYSARKIIAFDNNPQRVEFAKKYISPLTGKPIIDHVFLVKDLPTSSLKDSHASGNGNMTNGQTEALAHALGETGSGAGMGDGEMLDEDHEETIGDKKWEWAKKIVAGFVQEAGLTAEEGVDRVVEATGAEDCMLMGIAIAKQGGNYLAVGLGHIQTNCFPTLAVTNKEINVMGITRYTASCFPSALDLLSRGVVDVKQLITKTFPLTQSTEAFEAVAAGQDIKVVIKNQEGFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVA3</accession>
    <name>A0ABR3BVA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615045.1">
        <property type="nucleotide sequence ID" value="XM_066756268.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988572"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039767">
        <property type="entry name" value="RALBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783">
        <property type="entry name" value="RALA BINDING PROTEIN 1 RALBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783:SF5">
        <property type="entry name" value="RALA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="461"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="978" mass="103118" checksum="743D241E5F45CA12" modified="2025-10-08" version="1">MSTPDIATAFPVTPSDPSYKELPERPPLSRPLSEISANELRRRSNRSSVHSAPKKDKGSRPGSEVREKEDMQQTGGMAAGKRSQPSPSTASATGSVGRPASMSSLGPVIAPSSSTSIKQAPELPKRQSYGRTVSGASLKLSKIEQPDESSGDRHEKHHSAVLMAQRSSLRPTSVASYAEVAKSSPTSGPEPHSLSPSAIIPPKPPTKSKPSWLKRSAAGAGLRAKTKSPPSNDEDSPGSTTKPLPPILPPRKGKNKSRITESASIADLRSHSSETDRTSSMAPPDRSSYAFVASSASNPPPLPPRDTTGSNIKGRIAAWTAAAQSSSGFSRSESSQSLASQATGTSQYRLPSSASRVFGHAGSAVQKGWAGLRSKGMTSSMSISGMSSLASSSSRREPSRNSPLGGKRNRGSSDNQEVQGGPVFSGEMIKRPAEGGGGKVFGREIVDAGKEWGVVDAGFEVPGQSEWEMKRRKCLPAVVIRSCDYLHIWGPKEEGIFRISGQSSHVAALKRLFDSGADIDLTECHPRDLDPHAVAGLFKLYLRELPSPLLTHALVPKFEMAIGKKEEAAKRSSVVDSVGDEEFDALLRQLPQAHWFLLAEIIHLLDLIPKHADINRMTLNALTLSLGPSLNIPGAVISELLERRETLFKDPPPPSTIDTAHDLISFSDIDIPPVVSPSAKSSIFSTIDSPYSHKADDSTAVQDGSTKRKPPKLPSRPSITKLFTSSHVSLPRQKSVDTLASVPDTAPPRVDVAVSPTSPLPNFQSKSKTQSPDITPTREGASKPGPLVATYSSVASAPPSVPIATASSPGSMEPAEEVHYSVGTVEERARLFSTPTPIADRFISNQSFFPSLRASGNSTGSSATMRSASASLILPSGASRPGSASSATSVTNPASVIRRGPPVFFQSAGVERDRHAPGHVRSMSAIPSGVESASVTSGGAGTKRKDEMINEDGEDGRGKRLSAGPGVLDGLIRGEAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVI8</accession>
    <name>A0ABR3BVI8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102871</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614875.1">
        <property type="nucleotide sequence ID" value="XM_066757406.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989727"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF66">
        <property type="entry name" value="HISKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="479"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="100"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="651"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="846"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="911"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="956"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1179"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="854"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="867"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="959"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1179"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1208" mass="132135" checksum="967994C2DECAEBEF" modified="2025-10-08" version="1">MPAEDVDNAALSSATPLASAMHSHASNDQMKANTKANSKSRTRFAPSRLSSVWRSLVSHLTPPSHPSTTSESALGSSLRNTTDNMYYEDGSAVRHLPLELLNPNAGTDGRHKRRGVSDTKNSGSRGGLRQRLRGSQANSNSRYGDDDDLSAKPSEPVSRIVVDNNFEHFTPAVPKSDSGYGSGRTPATNGTPGGGEIGDDEDEEGTRGLRSDGASTTQRRSSAAAQWIQRNVVVEWVTDRFWPNVKHFLDSSYPEPSKEHSFQKELWFTQKQGALASSLFFIINYALTVGLLPTPFSNFNWIAYFGIGGVFTLPVLPLIVLDWPRRHPRIWQPVIFCACWVFAYILIVEMHLCGFFADNNQCGSRNFLNLLGFAFGQPTLGLLTMKEDRGMAVAGASIWIILTGALTMTQKNSPKLFYRNIVFFALFHAFLIGSSFLKERSDRQMFALRQQLKIQYRATQSAQVMERRAADSKKRFVSYIFHEVRVPLNTALLAVQNLQGENVFERVQQDQAEMVDGLVSSLSMMEKVLNDVLSFNRMESGKFAQARKPFDFHKSIQLVALSHRTQAQMTGISLDVELDPDIDKIGGIFVGDEMRLRQVASNLVSNSIKFTDQGSVRIVTKLLYPRLEPTPATEPDDPLRQAAINLQRQQEIEESEKALSGTPTRSFAANSQSVPSHPRSRPDSAKGIHAHVLMDLEKGSVTIEQKRLSRESGRDKEEEKKKVQKAVIRVEIHDTGVGLKKTDVLDGDLFSPYVQTEIGRRQGGKGSGLGLALVRQIVKLSGGRLGVESEFGKGSMFWFELPYSLPPSPKARPGSSKGDQMAGMGMGGGASALSLPVASGSGGKPSFGLTMPLSSSSNSTIVASSSRTETPQGSNPGIRTSTGEGIGGDDEKGPPKRPAAMVRIISGASLMSPTMEKGPSQTSAHSERPAIGTTDSTMPLLPVEPRMSVEEVITAGGVPQSPSTSSHSTTQEPFIDPFSPISYTTLRERRSSEWSEEMGRAALAVEKLESERAVAGMGLGMGVGQAAEIMLNAGGVQRQPETKEDPPAEMPLSSLVVDDDKLTRMLMSRMLTRLGHHVTTAENGKIASEMIKDMIENKEGSVKFDIVFLDNQMPLMSGVEVARAVREMNCPIYIVGCTGNALREDQDEYMAAGADTILTKPIHQKHLIEMIRDARRRVAGETQPRDMDYADESPMSPVPTRDPLPRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVV0</accession>
    <name>A0ABR3BVV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615248.1">
        <property type="nucleotide sequence ID" value="XM_066756471.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988778"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="81" mass="8847" checksum="925570A5F76BDDBF" modified="2025-10-08" version="1">MDVNENIHPTEHPNSSPSASARVREVGTEQDTLDKGIAQVIKEFVSPAQARDPSVVERASDAVRAGFKESTGKDFPIQDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVV5</accession>
    <name>A0ABR3BVV5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102747</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614754.1">
        <property type="nucleotide sequence ID" value="XM_066757285.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989603"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="10">
        <location>
            <begin position="151"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="408" mass="45857" checksum="9822C807A0C8D379" modified="2025-10-08" version="1">MAPNQDATDEQLYADLPSPLYLSPSELIGTYHPNVLAPLVRCSKLPFRHLTSLYETHITHTPMILAEEFSRAQIARTSDFSTSSNERGIYWMTPNNGKSRVKGDYQAHIGHPEDARPVKEPWKTYHSPPSTNRLPPSPAPPNSQAQLVRGCLIAQFASPNAKSLADAAELISPYVDGIDLNCGCPQRWAYNEGIGCALLRKPELVRDMVRGTKDRMGWGWPVSIKIRIDTEQKNTEQLISNALQAGISHLTIHGRTRHQPSTDPVNLPGIKFAVECVKGQVPCVANGDVWELEDARQMRLQTGVQGVMAARGLLANPALFAGYDRTPEECVSQFINLGLDYGFNFSLFHRHLAYMLEPHLSRVEKVWFNSLTSQASAIEWLDERGINFRKKRRTIWDARRGYNVIDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW20</accession>
    <name>A0ABR3BW20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615315.1">
        <property type="nucleotide sequence ID" value="XM_066756538.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988845"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="374" mass="39984" checksum="FC549CD57FBCBE5A" modified="2025-10-08" version="1">MPRHNSFSIRASSSSSQPEEAAAAVAASGEYFVQQAKLYKYLEKRFNKFNKKTENERQRPNRDRQFSKSIKSTHSTPSNASTSSPVSSSTSSDTLTRKMISSSIRIPGKLLAQVARPAVASASFSTTATAGARVQSKQSKKKVANPNALSASEATRVLRALEVAHPTSTYSLTLHTKSHKSALPIRGSFILPLDPRRTSETILVFAEPSSPSATFAKEAGAAYVGGDELFEAVLSGKIQPTRCLATPGMMPAVSRTLARFLGPKGLMPVAKRGGVAEGEELAERIRDAAGKMEYRADKQGTVKINVARVDFGIPSVETNIKSFIQTVRDNQAAANQTDDPLAAAGKSKKKKGSSITSVILESTNGPSIELNDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWI8</accession>
    <name>A0ABR3BWI8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidophosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615480.1">
        <property type="nucleotide sequence ID" value="XM_066756703.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989010"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="47"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0252760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="599" mass="64869" checksum="3C678DF77918129A" modified="2025-10-08" version="1">MLADEVYYLLLVSLRGRAPDGGAWRAGTGDVLVVQLIPLFPPAQNMCGIIGLLLHDPLATQTTLAGTELAEGLSLLQHRGQDAAGVVTCGSGGRFYQVKANGMVRDVFDEAAVAGLKGWMGIGHARYPTAGSSAHAEAQPFYVNSPYGICFAHNGNMVNTPALRQFLDVDAHRHINTDSDSELLLNILANNLQKTGKFRINEEDIFTAVGDLTKACVGAYACVAMIAGFGLVVFRDPNGIRPVGIATRKGARGGLDYLVASENIVAQGLGFNDWEDVKGGEAIIITREKVSRRQVAEPQVFSPDIFEYVYFARPDSTIDGISVYRSRMAMGEYLAETAKKELAKAGLSVDVVIPVPDTSRVAALQLAQHLGIPYREGFVKNRYVGRTFIMPGQTQRRKNVRRKLNAMPMEFADKVVMLVDDSIVRGTTSKEIVQMAKDVGAKKVVFASCAPPIRHSNVYGIDMPSPQELVAHGRTTEEIAEHIGVDLVIYQTLEDLVASCKQFNPSIEQFDCSVFTGEYVTGGVDDRYLEHLMRLRNDNAKAKKNQAAVEQSEVQLGCSGPMNGSDSLIGLPNHSPKIGPSAALSPNDTVGLHNSWFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWN7</accession>
    <name>A0ABR3BWN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615517.1">
        <property type="nucleotide sequence ID" value="XM_066756740.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989047"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="39"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="254"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="403" mass="42538" checksum="5C7B20FB4231E38C" modified="2025-10-08" version="1">MPSLPARLLARRALLPPRIQPRAFHHAVRPPAAPPPTALSALASRLSLRPSSPLHAALLTCLTHPSYSSAEDAATQSNELLATLGNSLLGLFAAEHLSTVYPYLPTKPLQHAVTAYVGPASCLSVARSLGVAVQGGGNTGLPGLGAGASSAGVAVRWSKTALAERNWRDTRGEAAQGPLKVPVGKRFKKYIKEEDQDVTVQARRETHEDVVASAVRAFVGLIYQEQGIHAARAFTHAHFLSRALDLSSLITPTNPMQTLSSVVSSHLSSTAGVPASSSHTLIQPRLLASTGTASQAPLFLIGLFLPSGIKLAEGHGSSKAMAQHRAAVNALQSIFFMRGDQESAQVLGIKGLGRPVGEFGEGLPSSAHEEWVFDDGKVVKGEEERSFEGVEWGGKEVLPGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWQ3</accession>
    <name>A0ABR3BWQ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615538.1">
        <property type="nucleotide sequence ID" value="XM_066756761.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989068"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="1177"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="827"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="908"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1575"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="827"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="856"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="910"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1621"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1671"/>
            <end position="1680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1729" mass="187082" checksum="8475F521C2235979" modified="2025-10-08" version="1">MPERHCHADDGADRSGHDIMSPSSEHSATCSPPPPPPHFNPPAGFPADSPSETISPPGGAAIISPTKFFPLDVAPFRPSSPSIHRISTETVPTPKSEASSVSSNQSAHSEGGDHLVEMRERLRSESLTSSTPPGRSRASSQATHEGSRLSVTSSNASSETVIDDTAEEQHYERSGPMRRLSSGVLAGLEEAPDLPIEHAWDSVWPAASSIHRHVLPEPGLARFPTAPVSPFVTPSFSPAVIPTTSSSRRPKSPSLEFHDPISPIRSSAQSPGTGPFRFSPKMDANSPTADHPHTIPDLGDYGRRPSISSDAALIPKASPTVGVVPITTSKHGRSLSTSSQNSPRALPAQNQPQIPPLSGPANRLTNPGASPPLVPSTASSSSSLKGRPRGHSLSSVARNKSGLEPLTQASIRSPSPLTGFAHPAFNLSPHPSPRSSPRNSPRFSPHPSPKLSSHTEKQKPAPAAESIHEIIESLGPSSVPPPIALPPPVTQPQSSLSPPSSSSPHIPSHRSPSPPLYVPLARPAIFRRAISDYESIQRPNNRSTPVNIQRTLSDSTEIDKADRDRDKIAYVKTPGVTYGDMLGPVISGGSRLSDKEMWKRMSPRRSPLSLPSLSPVTGGVSDEHEVVQSPMAMTHEEKADLEQAHMERNRVSSLFGDRQGHVPITSEGQIQNPYADWPGEPIMSTVPAHDQMNEPYSHEIGLVDEGDVLPTADAASAVPAIGFDEEGLNTVERIFLLSRAEYPFHRAYIARVLGDLLNEVDPCESVEYVLPLLSGLSMDEDESVKEAFAQELHRILWYFYSTCKLQLDEVEGQGEYGVDQAGMMEQAEQAYEQGQQSAGAEDAAQSARANDKVSVSPPFNSNTDSPSSSPTSRKETVTVTSEGVNVVHKPTPAEIDADSIVVDVTPTHRQSFNSSGSTTQSSSGSSRPIGSSNISSGDDAFELSTPGSSVSEGTAYSPGMFINPHADDEDGPIVKEGVLVDRPALQVSFFTPLIGSLLLSQNPVVSESVRNGVVNILARLRGQDELTVEVWGQSALQPEPDERRTFQTQMGPHQHDLRPFMPEDKLMVECELLQNIIIGMGNLSTDTSEMDLGDSEAAEDQETFQAQLIQEAITGQATSINLIGAVCETYTEEEVLEHGFVDELLRAGSGDGIVRAEAAVAMSSLAKRAPVEQVHRMIPLFEQLCNDVYDQVRQSVCMALPALCKRIESFDYRREFAIKSIQTLTSASEDVRMSALEMLGEMIYIFHEDPRGPPQELLDIYLDDSEVEDGTTDSDWDTIAIFNFPGVCLTLGSDRWHEIRDLFGRLQARAGEKVMATTAACLHELAKILTPSQVAEDLLPVYSALLKGTEEVRERVFEHVEVIIASVPTEIGWKLFQNLANSWHEGTLGGWRAREKLAWRIPSFLQTFAGWGGQEQVLEMMKAALLDPFAAVRDGATSGIPKSYEVITEDPKSHIAHSFHSILLELGRSSSFKQRLTFVRCLREFVKPPPNRNAFEDYFLPQLSPLARDVVDIRLSLAQIIADLFVVGAYYADVARGIPQQIRELATGLAKDEAVDVRDTVRKVDLSSFEKGKGVPYEIEDTSAPDRAAKPDNMDEPTVSDEAPNSRNDAAGAIGMPSTGSASASIQASESSNSSAITSASLSRSSSSQSSVSAKDTPTRNCSPRAQIHQATEDVSHDKSGSFYASEDFNNEETPTLSQKEWFGEQSIKSEDPFAASFKKVTSEQPDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWT0</accession>
    <name>A0ABR3BWT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rad51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615558.1">
        <property type="nucleotide sequence ID" value="XM_066756781.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989088"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051988">
        <property type="entry name" value="HRR_RAD51_Paralog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad51-like C-terminal" evidence="3">
        <location>
            <begin position="86"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="364" mass="39970" checksum="D285E0B8C6C9E889" modified="2025-10-08" version="1">MLLKRIANKLPSELALLIPELESAGIKTTESIIFTHQPTIISSTTTLSSQQIEAFIWYCILLTAGKSRLASDVDNCKIIGPWLGFGVKGLDELLGDWDGVGVLEIAGPRKVGKSLLALHAALNVLVEDAQAICTWMDTEGTFTPERARKVLEAWKIENATSVLHRIMVVPCFKLEDMFETLGGLKEKAIGQADEPRTKILIIDNIFTHFKDRLTNTSAQGHAELVAVMEDVADITYSQNIVSIVINSTVTCIPTNPLSRFNKLNIKPALGSSFTYTTDATLLVQETGKVFGMLDEEERERIKKAAGLRGSVEVVRSRVSRTGGWAVFETNGTKLYNVVAPSNISQYPRGLPRTVMGPLRDTMIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWT4</accession>
    <name>A0ABR3BWT4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615570.1">
        <property type="nucleotide sequence ID" value="XM_066756793.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989100"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF55">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046224048" description="Acid phosphatase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="59094" checksum="B06F9A71C8025426" modified="2025-10-08" version="1">MRSVALFALLPILANAAAVERRIADSNVGSTTSDVFPPAGTSVNSKLFPPESVVGYPGATVTGAEPAAAATAAAYAYNDGTSNNYPLVADQPNNSSSGNFDVFKYWGNLSPWYSVPSSFYGLNDTSPLIPDGCSVTQVHLLYRHGARYPTSGAGPSTFAAKLATAAAQGGGFNATGDLSFLNTWTYKLGAELLTPFGRLQNFELGVAFRQQYGELLNNFTEQGALPVFRTESQDRMVKTAENFAAGFFGVPEYLDQVSIELMVETSGVNNTGAPYDTCPNSNVASRGSLGSTAASAFAKQAFNGTISRLQSNINGVQFDSTDIIDMLQLCSYETDALGYSAFCGLFTEEDFKNYEYYYDISFYYNNGAGSPVAAAQGKGFLQEFVSRFTQTPITSSNSSVNTTLDNNSTYFPLNQSIYADATHEVVLLDTLTAFNLTALFSTGPLPVDKRVEGSSFVASQVVPFATHLVVQVLECANQTPTKQIRFIVNDAVVPIDKSYEGCGSNKDGMCAFDTVVAALQKRIAEIDYDYDCRGDYTATVGNDYNGRAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX57</accession>
    <name>A0ABR3BX57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase D 3'-phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615703.1">
        <property type="nucleotide sequence ID" value="XM_066756926.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989234"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465:SF1">
        <property type="entry name" value="DNA LIGASE D 3'-PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465">
        <property type="entry name" value="DNA LIGASE D, 3'-PHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase D 3'-phosphoesterase" evidence="2">
        <location>
            <begin position="102"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="692" mass="79097" checksum="7002DB246E7C01EC" modified="2025-10-08" version="1">MWTLHQLTENKATRRTADSPSPSPSPSVNRKRARISSNSPTVTPSLVKKENERMSSEKSDPNELEKDEDGPKPDVEREWEGFSKDVLEKWPALKKRNFWCIQRHSATALHYDLRMHLGGVTVSWAVPKGLLGISKSGEARRMAVETTLHPLWYTIHEGSDGRTFGQGRQGGTLLWDIGEYTIDLPSGHIPDFDTDEEEEAENRRRFKKRRKDSENDGREEEDKFRKALHRHIRFGKSRSIHFTLKGGKKMTNHSFILVLSSDPNKYSNISPEGKEKKTWFITLPRGVDGYPWDQGGEDGSFYGRSVKSGMTFQQVSVSGGLAMILLISLCENNRLFGKMPAMLPPHRQKRSVTVVRKNMGSRHRHLIQIAYCQLPLSIPTDFMHLVFEDVLTTLVNLLDGTSSNLEKEHFVVAKEKWEEIGRAIANSGNTIPSCFAAKFPISLSPDRDVRLTVGRSGSNILPVPSMYYKHIMRFSELESECLEFEYRRDRVPGLTRDWARWVEDYERLYYKDNPTRLHLCSSQVHMFLRIADYIQAFGPDWVWWQFAICEWLGWIRGGLEYTVAVDRNMRYQHRAVDPQPRLCYVSVSNTQRSYLPGSERESSLDPFYLSHEARARQMANDSALQASLMLRDALSKLVNFVSTNFASINQTIRGFDDRVSQGLVSAAVRESPTYLSRTGASRDDSGVLALHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXB6</accession>
    <name>A0ABR3BXB6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615230.1">
        <property type="nucleotide sequence ID" value="XM_066756453.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988760"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046381610" evidence="1">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="160" mass="17514" checksum="F05B9F8BFF12DA7A" modified="2025-10-08" version="1">MFKPLALLISSFIILLPTVWSSAATQYHLDVTKQASSCFLSCHSRIVNIVHLEGTSSNSYQWISQNCKNDEWKSMMSQCLPLVCSSAPDVAYATEYGESFCKRAGIDNVVIQLPKSYLEGANGTYFTSEGYLESQAVGELSINKAMMGGTILGALSFFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYK9</accession>
    <name>A0ABR3BYK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD-repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615074.1">
        <property type="nucleotide sequence ID" value="XM_066756297.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988601"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="488"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="541"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="815"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="663"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="674"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="883" mass="95433" checksum="CE1B5738F0104C6E" modified="2025-10-08" version="1">MPSEAEYIGTNAVVLNINPLNNLQLPPNLPTISSPHPRQAVGDPSAVHSSPAALSVGIQESFSNFEADSAKPTSYQAIATNTITGTSSGTRVAQSELTSTRGTVRPRSSSADEESAPPKQRIRQSAASSSPSTPASVVDSTANRNHMFGNMGQPIHDDGPSTSTHVAGNISNGHSTVQPGSLPPSFLSSIIPVRPPGTLMYEDDHDWASVQEKLKDQGEVEGRMEVDGDSDGKGKGTALTVGRPGAGGGKRMPVEREEVVRLVLQGLRDIGYHQSADVLEAESGYQLCAGAATDFQNAILGGRWSDALGLLPELGISVSGSPAEAGPSSESSSTTSDKVSNGVRSGSSLGDQARFLISQQKYLEYLEVGQQKKALSVLRGELARVAKDQDVLHTLSGFMMCLDKDDLYERAGWDGSQGISRRQLLEHLQEFISPRLMVPSRRLATLLDQARQQQQSTALYLDHPEANSLYSDYRNKPDQFPSVTTHVLVDHTDEVWRIEWSPDGTRLASAGKDRIVVIWNVEPTTREDGSVRYNVTPSHHFSDHNDPIDSMAWSPDGKLLVTGADKNVHIWDTEKGVQIPKQTPGWQHTDTISSIQWRSDGSEFLVTSMDCRIVFYNPAGKLLRQWSTFPLQFNDCCLVPDGSMLIAITTPLKRVAHNDRLKQAMSGRPVENNPSRSGPGAAGSGNTTAATAGGGLTLLGGPEFGFATMEHSIVMVRMSDHEIIDWSQDLRCEMTSIKLSSDGKRALVSCSPDEIQEWTIYPGLKYLRRHTGHIQGNFLIRSCFGAVKDQFVLSGSEDGHVYVWQGKASHPIEVLSGHSDVVNAVAWNPIGSRKIFASCSDDKTVRIWQPPTSAVDVPAEAGLSEKVEAENSFTASAGDGMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZU4</accession>
    <name>A0ABR3BZU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616073.1">
        <property type="nucleotide sequence ID" value="XM_066755787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988088"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0253852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49028" checksum="77B4DA0E856D59DE" modified="2025-10-08" version="1">MSLESITTPREAPSNQRLVLPAVIVTAIGSRELAPFAKQERSNVQGNCLNVKIARDTTGLASTALKWTEEPHSTAQLKIDELQSRVQKLESVLAAQRDYIHISSLTPHNHLLSNHLPSTELLNQEGTDGTEHFGTGRLVLSSTGNLHLHPSATFYCSAHVIPEWRQALDTLNNTRSVPLPAYLAPLLPSHTTQAHHRKLVDLAFDCLLCFGPNPLKDKFVDSMDFDPDRRGLYFSPILHLAILGAGWRYCSDPGMLAMYYPKSPIENRGLEYVDKARDMVLQEADTGHLSNMLALMVMTLFHVGQTKDTMAGSCFNEIAELLFEHQRSRPIHLYKSGNTDLRLLSLMALYHSKLSHYGLQSLSTNHLTRMPIEIRIKHVRELGAYWFSGETTFPPKLLGHHLRMPRSCTRATLSPTACTPRTLSSFIDLTLSKLAEGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZX4</accession>
    <name>A0ABR3BZX4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urease accessory protein UreG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615902.1">
        <property type="nucleotide sequence ID" value="XM_066755616.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987915"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="112"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0253681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="314" mass="33719" checksum="F2EA0421680BB250" modified="2025-10-08" version="1">MAAPAQPSSTPPVCQFSDRLATALNAAQEATGTDTHANHHHTSSSLSGVSSNISHAHDNMSHDHGHFHDHGSGLWTPEEHGHTHEHLEHAGKFAERDMPDYSGRNWTERAFTVGIGGPVGSGKTALLLALCRGFRDKYNIAAVTNDIFTREDQEFLIRNEALPAERIRAIETGGCPHAAIREDISANMGALEKLQAEFGTEMLFVESGGDNLAANYSRELADYIIYVIDVSGGDKIPRKGGPGITQSDLLIVNKIDLAPHVGASLEVMRRDAAAMRGTGPTLFTSVRNNDGVDAVMDIIVSAWRASQGNGKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C004</accession>
    <name>A0ABR3C004_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616188.1">
        <property type="nucleotide sequence ID" value="XM_066755902.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988204"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0253967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="227" mass="25018" checksum="2DE1795815D4B385" modified="2025-10-08" version="1">MAVPRIAYLSHKSVLELSGPDAQKFLKGLSCKDVEYLGGGYSGFLNASGRVLHTAFIFPRSKNSYLITHESPEDHPAPLLSLLPPFKLRSKVRIKDVTNQWDAWSAWGSDLQGGPHPIRTWKMGSGGASESHWDWEGGIRDIGLRDNEAGCWDLRAGWPRMGRQLLVPKGEKPSLATSHDLGNIHDYELHRMLLGVPEGPKEILPGQALPLESCMDIHGGGKLIKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C072</accession>
    <name>A0ABR3C072_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616007.1">
        <property type="nucleotide sequence ID" value="XM_066755721.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988020"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="96"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0253786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="355" mass="38876" checksum="4A12B2D319463630" modified="2025-10-08" version="1">MRSSLIRNTRHAPITSSTFTPRASPTIAHFASTIPSRSASPSTRTPRLAGAQIGVYHFHSYSHRQAPSIEEQVPVQLAYDVVEPSNPFPEAAGQSLVICHGLFGSKQNWRSLAKAFAAKLGMPVYTLDLRNHGHSPHASPHTYSAMAADIHQFFVSHKLTSGVNLLGHSMGGKAVMALALNSDLNRPLRSLISVDMSPARGKISPEFASYTDAMMDIEKAQVKTKHEADVILQKTEPTLSVRQFLLTNTRLSKSPFPHLTFRIPLALLSAAIPNIGDFPYSPPPPVSAKSPQWNGPVLFIKGEQSKYLNKGNIPVASSFFPQMRLEVLDAGHWVHAEKPIETVELVRSFIQGVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0R8</accession>
    <name>A0ABR3C0R8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616443.1">
        <property type="nucleotide sequence ID" value="XM_066756157.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988461"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="3">
        <location>
            <begin position="228"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="383" mass="43667" checksum="C03EF3D7EABB402F" modified="2025-10-08" version="1">MPFNSHGNNAPLLPLTRHSFSDPFLRRSTARRLSYGIKNRASQYPYSVTIGGILTFVFFLFVYTRPVSDFGRFNSATSRLHIRTADEDLFPLPTPEHKIHRPDSKMDNGVMLLTVDENELIAEDDLFWDSYTEAEPLSVEEAAAEAELLAHKQNVQAQNEAQSLRALIWWLAEGGVLPNDFEVPSKSHLRKIGSSGFEKLLSSIDAGDENQMIFEEGWADFADRRYSIVVFSKTYCPYSKNAKSILGEYHLSPAPFIIELNQRSDMEALQDFLQRFTDRRTVPNILLDFISIGGSDDITLLHSEGGLQRKFEEMGAFPGLVRREASLLSNAEESGKDREIEETREELPVETRTETKGEVPEMDLYEEEQEEVYDIPAERVWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C143</accession>
    <name>A0ABR3C143_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cell cycle checkpoint protein RAD17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616322.1">
        <property type="nucleotide sequence ID" value="XM_066756036.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988338"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="715"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="733"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="749"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0254101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="771" mass="84751" checksum="14B4B3ABE1FEBC3E" modified="2025-10-08" version="1">MSSSLAPSSAGSSKPVKKMGSLSSFQASLSFKSHGLGSNKKEQDRKLMPPPSRSVSPVKMDSSHKGSETSSTSKAVKIPSAKEKGKGKNPEIIEVLSSDEEEERQAKVTRRESKTAQSAKKKEKKDTAQMWSDLYAPTVEADLAPGKARIQKVKGWLHESLYGYPPDVQPPPLSTSDKLRKYRRILLMTGPAGGGKTTTVRLLAEQMGVDIIEWGESIEEWSLGTGIERESSISKFSSFLSRNSYPSLNLSQSPSSSSSRSVSQSRPRLILLTALPNLTHLPTRDAFHAALLTFCQTFTHSSCPMIIIHSDAGSGGRAEESWMDRDKGGREGVVNIIGKDVKNGPWCQEIDFIPVAPTFILKALNRVISLNPLPPAQRPTKATLQLIAQSSNGDLRSAINSLQLLCGGRKHGDKDRVGKKRKEREEEVVSGSKERGKGRGSMGGRGAKLDVGSELRTVLDAVTRKEQSLNLFHALGKVFYNKRLGDPDEGKDEDQEVLSAIRQLPPDDPLPEHLSGYTRRKALVQMEDFIPGIPIDSSSFALWTHQSFPSFCTDVEQVAEGMDYLCLADVMRTDDDIWHSSPQSIAYALYLTIRGIHIALPSPVIRNRHKVLKPQFFKAFAEGRDNQLALEGVGRYLEKKGTVSNNREAAAWGGLVGKRVMACEMVPMMVKIQSLSNHPLLPSSAQTLVLPPYTPLTQYHISSVHDELTAKTELGEDEGESLEATMAGDDGMGDVRGHEHLKESVWDNEGVEEDEEGEEDYLVDDDIVDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3T5</accession>
    <name>A0ABR3C3T5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_101534</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616375.1">
        <property type="nucleotide sequence ID" value="XM_066756089.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988392"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="454"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="159"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0254154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="887" mass="95872" checksum="F43E456E78390F6E" modified="2025-10-08" version="1">MSRHRFVRNLDLDDELDDGDEEVGMSAEEAAQMNRAMSVARNLLRDVTPSIPDNEIADSVWHYWFDGEKAAAWLRQDREKKGEAPPSYLEPTPLQQPRRRPNNLMLPPRPPQPQEDIQPPLTALQRLTLSRRQGSPAPPAASPSVGEKPMSKLALLAQKRREAAAAAAASETVQSESVLPQTASRPSAPGMPPDSGAQSPSQPEKKPLSKLAQKMAAARAAREEAAAAAKASKVEKDVSEVQMEVDESSPSVPFPEDPISSLFSSPATLSKPKLEPARPSPFFSIITSNSSQGEGPAKDHLPPEPISANLHAPLITDVDALVKQFEQAFTESPDEIVLLAKAKAAQTAKSASLPGKPRVQQVANQKSKLAVSQPNSPSTSDSKATSKSGSTSSTPRIVGKSNLSTDLEGLHLNEELDEAEREREREKFKERQVLSMKQEELIAKAKEEEEKSGKKNVSLIVVGHVDAGKSTLMGRVLYDIGELSEKEKIANERGSKKVGKGSFAFAWGLDALGDERDRGVTIDIATTHFMTPHRNFTLLDAPGHRDFIPAMISGAAQADVALLVVDGSPGEFEAGFERGGQTREHAWLVRSLGVKEIIVAVNKMDLVSWSQDRYEEIVESLKPFLLSAGFNSAKTTFLPLAAMEGINILDNDQPQLKEWYSGPALIDALDNVEVPTRPYDSPLRIPLSNVFKGQTAVASGVAVSGRLCSGVVQVGDRLRAVPGDEVASVRTIEVDEDSAPYAVAGQNVTLYLSNIDPINLSIGTVLCPTSIPVPLVTKFTAQILVFDLQSPIIAGTPVELFHHSMNLPATISRLVSILEKGRVVKERPRVLQKGMTAMVELSLRPSSAGRISSIPLETATDNKEMGRVLIRRNGETIAAGMVMELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3W9</accession>
    <name>A0ABR3C3W9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616600.1">
        <property type="nucleotide sequence ID" value="XM_066754699.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986979"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="421" mass="44902" checksum="AA6994325F62C4C4" modified="2025-10-08" version="1">MAENYQKKELLALMSTGDNKICVDCDALSPQWASVSYGIFICLECSGVHRGFGVHISFVRSITMDKWSDEQLNKMKTGGNGKFKDFMENYGPEGGYTKGMGMQEKYNSWAAAQYREKLAAECAGQPWSPSSPSANFGIASRPASVQATRKSRATGGIAGSSLNPSRTNSPSIPQGSDDFYGQKSANEAFFERMGNANAARPDHLPPSQGGKYSGFGSTPEPDVAASHPSYSLSSHAAPTLDEFQRNPFGALSKGWGLFSSAVASAGREINNSVVQPGLDRAQALAAGENSEEWKRYVNQASAQAKDASGWLGQRAQEGWENLNEVAKTKGGVDLNEKFGKLGLVGKSNIPGSKSYGQVGTLDRAEDGLLSPHGGKNDEEDFFESWGAAPTACSASAPAGTKSVADKGKKKDDEGDEKWKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C414</accession>
    <name>A0ABR3C414_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pod-specific dehydrogenase SAC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616645.1">
        <property type="nucleotide sequence ID" value="XM_066754744.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987029"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40550" checksum="29D166CE07038D35" modified="2025-10-08" version="1">MSFWSNVWLWIRFQVNAILHSGFPCFFWVRPTWSVDKIPDQEGKVVLITGGNSGTGYATALALYNAGATVYLACRDLTRAKEAAEDIKKGGERGIWGVTYPSEELDKAGRNKKGRVEIIKLDLTDLASVENCAEEFLNKEKKLDLLFANAGVMATQEGQYTKQGYTLQFGTNVLGHHRLITLLLPLLLSSPPSCPSRVILTSSVGHLTAPKGGVIFKSVVRDPSDTGSGRGRYELDKWTEYGQSKWGNIALARYLEDTYGKDGRLISVAVHPGVVATNLANHLPLVDFVAERVPWLRHLFARDPSTGALNQLYAATLPLPDAWFLNGEYVVPYNTVGMCRPDLWNKKRIEEVWNWCDEQGKKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4B3</accession>
    <name>A0ABR3C4B3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616745.1">
        <property type="nucleotide sequence ID" value="XM_066754844.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987130"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="8">
        <location>
            <begin position="61"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="402" mass="44148" checksum="C8EAFB653E87992E" modified="2025-10-08" version="1">MSTIEQKEAYQDGGRILSIQSHVVSGYVGNRAATFPLQTLGYDVDVINTVQFSNHTGYGFTDGHKTSPDELAAIFNGMAINGLLTHSRILTGYIPSAQALGVVADRIRRMKTDNPSLIYLLDPVMGDIGTGLYVSRDVVPIYREMLNMATIITPNQFEVELLSGIAITSLETLQKALKKLHTFNQLPHIAFSSIPLPISIVESLSLPAPPPSYTRLLPQPLPPWYDAVGTAAPDDEVLVCFASSWSDGQMETYAFALPTIRGYFSGVGDLFSAMVLAHFKDPKAKTNLPPLPWAVSKALLTVQQILLQTHVHSLAQAEVVGAATPRPLHHPSDPLSADSVIPSDTELDALKPSNPKDPKRKARRMRLRELRVVQERALIQDGGEGWPGKKMDWTYISEQFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4G9</accession>
    <name>A0ABR3C4G9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616800.1">
        <property type="nucleotide sequence ID" value="XM_066754899.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987185"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="245" mass="26405" checksum="23C34DA296EC9D17" modified="2025-10-08" version="1">MPPLPFHLSTILRPLSPSLATARLKSNVFALVLFSLRNFFPPFRAVRSLVLQACDAAQGRVGREKSFGEVGLGLGEALMTLILVWNIIEAIVALQYPSTYVPPQPKGMELTPTKISSPLTRSYSPRPSTPSQAIPRQLYRPSPSSLNQVQQTPSAPSQAVARTALSNSTSTPLSSSTAKILNLPPTESPSNGLFYERSQERSQGTAGTSGTASMGGDFVLVDRDEKEWVDNVWKGVRGKAGRVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4T4</accession>
    <name>A0ABR3C4T4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616915.1">
        <property type="nucleotide sequence ID" value="XM_066755014.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987301"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="334" mass="37062" checksum="66761DCC839B3807" modified="2025-10-08" version="1">MRKIPSQVPSAVSRLLQGQVISTPPTWFQPVLSHPPPQLPPYQVKSRPRASDPGIKSSDFIDTVPIRAGELERRDKLRGYKQRKGRPLEIAYEEDRVRRQFFKDFPFEALRPVSMVEGREIDVRRKVLGEAWVRLEQRGLYPTVEDCIEFVINLKNTRNVSISEAYALATEEFVSLRGRHQLATLAAEIEGRHYGAEFKPDVFERAFNLEETALETLQPSSSSSSGSSGSAGASPSRVKYREQPRWQWSNTVPPSSLPPTIGGFSAGQEYMSKWKMPEPLRGAAARGGEGDLLSAIPTATVQAPEEALAEEDAKLEDLEILKAALGSSKSSSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4V7</accession>
    <name>A0ABR3C4V7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_100453</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616925.1">
        <property type="nucleotide sequence ID" value="XM_066755024.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987311"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0255648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="386" mass="42536" checksum="A584A60235748177" modified="2025-10-08" version="1">MSAKTVRAVHAEVSLSTPLPLSKRSRSAFSEAEKQGLLQNFDLEVQDKLQYFRSMLTQTLSSFSLREETEILSIPRELRNMTLGELEEKWGGGWAGTFHRIKAERFEVQEKEREEREEKGREEAVKGKRKRNVAGSSRGNSPARSTKNPRREAPTPSSIRNTSRATSSTAPARAKSATTSKRTGKAIVALSPKSASGLPQDHIFNPALPPTPFRSTEAGSGVRPSPISKASNSYSRSRELSDNSGNMTSVNEDSLEGDEEEDDLPDPEAMEARLLSQPKVKSPSSKSRSRKKRGPSLIFHQSLGAKAKIISGPEPSGSLDSDEPLATIQLSDGREISFNPFSLTPGRVERELEEGGVSKEEKVRVQNEVHAEVVKSLQARMEKWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4X7</accession>
    <name>A0ABR3C4X7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100487</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616957.1">
        <property type="nucleotide sequence ID" value="XM_066755056.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987345"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="138" mass="15296" checksum="CE736B795E9982F8" modified="2025-10-08" version="1">MWLSDAQKIGIALVAFGIFFQFLGIILFFDGPFLALGNILFLSGLPLIIGLTKTFYFFSRREKWRGTLCFFGGIILVFAKRPVIGIIIEFVGFIGLFGSFFPVILQALRQTPFIGPILSLPYIRGAADRLAGVRQSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4Y0</accession>
    <name>A0ABR3C4Y0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616929.1">
        <property type="nucleotide sequence ID" value="XM_066755028.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987315"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF456">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="525"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="800"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1355"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1485"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="825"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="890"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1419"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="549"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="680"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="750"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="802"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1375"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1525"/>
            <end position="1542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1542" mass="170905" checksum="4685AFF839C9A69B" modified="2025-10-08" version="1">MSLFKRKHSKADLHPPPAATLAPGVAPPVAPSATPHRGQTYGNVGIGGNNNPRRMTSNPQLKSNAQASYPAHSSQSPPLNQHLPGQVDTQSGHMSMGMPHPQVGYRTNPQSPTPSASGPGASGGYAGPSHPGMSPPPIHSSAPAPVQMPAHIQASAQPHQGQFQYQAPHSNHPQGQSQELGQGQLQSRPHPAPNPLSYPWQIRPLRLYPSGQNAPASPFPRYGLSVPCFPSHSGHMLLFGGLVNEKVRNDLWSIDIRDLSVMHVKTKGDAPPPRVGHASVIMDKIMVVWGGDTKVNVTDEQDEGLYILDLRSQEWTKILISKGPIGRYGHAACMVENRFYVFGGQADGMFMNDMWMYDIKQLSGTTAVHTWKQVSYTTPPPPRRTGHVLVAASSGKLYLFGGTDGNYHYNDTWCFDPSTGTWAELSCIGFIPLPREGHAAAIVDDTIYIFGGRDVKGKDLGDLAAFRLSNQRWFMFQNMGPSPAARSGHAMVSAHGKIFVIGGEANQVPLEPGERDDPQKIHVLDTSKIKYPHDAKSKITTGDQADSKGTQGTPQPGQQQGQTQGRLPQSFSAEGLNTRAGTSSPSSERGRSTQHVLPQSESQILDTQVSPKPQAQTPHPPLQSPRDVGPVPITKPNDGPPQRPRREDDDEYREAMSPTKLHYSSQASDQAESPMQSSLPSRVTSPTHTSPTSPRNLPKMFYSSVNGARSPSPRLRSADGPSLERERAPPPPDAFYYGRRSPTTNGFRQSASSRPSSLGPSSDIVKELRAKENEVEEGKRRETTFKLILNRAVKQGFLLGDEEQKPFGRDKEGQADDNKQNDGLVGRLTDALVRLKKEKAEMQNDLVAQIRSASAKSLEADHLRRGALQETAFYRAKVAALEANSPLDLKRVEKERINELEKQINILANENAQMGKELELEKEGREQANTLHCSATQLEAETLKRAEEAEEAQREAFEELERLRGQFLTYEQDAREHTEQLITLSSQVQQREAERDQLRSQLDEAIATRDQNVQLVGEVQAAITSAGLMASEMEAMYAKESGKVQQLEEELAECRAELESRTKNAELAAERLKEIENAYAKSREEADALRAVTTSRLGEILDSHKELRADEARAARGHQEQLQALEEEGKSLRKMLQEAGQRVDAAESGVSQHRTKMRDMESKVQALRGELRTTQTKLLSAQAEVARYKQLHSTRDEELKEKEMAMTEVETRCTMFRNLLADHGIAVEDSNFDNIKEPSTRELEDKLRERTRANEVAQREIQDLRIRCEEAEVKIESLGKLVERIKDTRSPTSPNMRSPTPTGGEVNRVGELEKKLVDMEKEHRDKVAGLETDYQTAVRYVKGTEKMLKRMKDELNRQKATNTAIQTELDHARGRSSISGRSTPSSSSVGESDIQRRFIVLQNQHQKLQEDFSASQDVLSARNREVDLLRMRLDEAERDMESLRDDLAQAQHRIQTLLDVRGGSDDEDDGSLEATMAFDKFSQELKQWERSRSPGEAAFENKSLEEGATVPDQSTSYQALAMAQSSKSHSRSSSEYSGDWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C563</accession>
    <name>A0ABR3C563_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617041.1">
        <property type="nucleotide sequence ID" value="XM_066755140.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987429"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="947"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="500"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="865"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="501"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="872"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="910"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1366" mass="149105" checksum="C76A2EAE11E2BB8D" modified="2025-10-08" version="1">MLFRTYNPQIHPMPTSHLPLAGPSLPSHRPRTLSLHSHDSHPQHDEQIHPPRKYTDPTRHTHHISLSQKQDQELAVDLDAYSTADYGDEAFGDRDPTLSFVTSSTVDSVAGIPQVAMTYSHSSRITDAKGEQEPNVPMRSTSGRATTYSSAESSTGSGAFSYHTYSDHIYTPSPPLPQIPDEHNSSDTSSMTADYPIPRSNAERSHAHQIRPPLSPSHSFTHRPWKRDVVNRLRSDSVSSAFTAASTSTDDSATSSSQIPLPDAAYHYAYDDFTLPYEQEQAEPEALAMIKEGREKLLNMEKIDAMGGGEALNDSVICSLAGVTHLLLPSCGSRILDMLPRLLSVLAPSLVVLDLSDNKLSLLPDSLQCCTSLEELNLSGNTLRLLPQWMGNLSALRVLVVDGCGLTVLPQGLCHLHYLHTICVRRNKLVCLPPWLCLLSHLETLKVDGNPFTPEWARIVPPILGGPLPSMASSSRGRNAHHRHLSINNGIRTPVSMVSLESSDNEPNSASSSTLNLEQSSSGIASSSASQSTQLVSALSSIAEDNLHSAPLSKTHAIGGSLTSPELMAGTPHSHGSLRKMRSAGALLRSLDQPTSNTSSSFTPTRPVIAERSATEGRRAASAMGNYQEELQIQPGKLVKSSAPRTTAAPTKTGRWGFLRKMSMNRLRPDKEKVTAIATSASDNLKSLPPLPPIRHQHSDPIQHVTIRPRMVSTVSAATLPSRKIADFEPLEFGQMSSCSTPSALTMPISGLPYQSSPMSMTSTGTGLGLRGKRRSFLPIDGPPLINVQIPTSAFSTMSTADNIPQLTTEALTPQTTILPHTPAQPMVGSPVTATEHEERYIRGLDTIKLILRDLHDLSRRSVMPHDGSGVMGNSSADSSYAASVPSEHPGSPLSSNRDSFINVRQARRPTLEGDARHLPAADSEEFNERERSLSISGKKFKNDKSKRTKCIHEIWETERTYVRNLGELIAIYVEPASKPVNQSKSVVETVVPAAERKIVFGGVESILAIHRDNFLPALENVLRQLVENGDDEKGTLSIDTAYSVGEVFRTYIAYMKQYSTYITNFDNALARMKTWSLSNSGSSTPVFSGKSSAANVSVSALAAGMGAVSMSAAAVQTASGQSMSSNQRKRVKNFLKKAREHPMHSQISLESYLLLPIQRIPRYKLLLTELAMCTPARSDGLSDSLDDALTEISSLASLMNEEKRDADSRLRLLDWQKRFTNSGRSPLVQPHRRLVMEGPLTLSRIVKKASTFVECETVVEGDGNDTIIPGRAVVPVDYVMPESVEREVMLILCSDMMVLATDRGEGWDGHVNVFNVLRMTTMIEPASLTGGNILRVVDNSSIYYFRGVSRENTLQWCRAINSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5F9</accession>
    <name>A0ABR3C5F9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617134.1">
        <property type="nucleotide sequence ID" value="XM_066755233.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987524"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33889" checksum="5CD6E514C9F97A78" modified="2025-10-08" version="1">MSIPIGTPFRSFRSSSTTRSVRTFVSSSSVTHTAELSLRPKNGSVLPGESPEDAWKRNLQEARQWRQHKEYQRSTLSVYIPEGGPAVPESRSSRSPYEATLSTLLASGAALGHAANITSHAYTPYIYGKRAGLSIIDLDQTLPILRRTAALVKDIVKADGVVLIVGTRPGHQKMIQKAKERLEDNGFAIGQWIPGLLTNAETFFGMKPLLDKSYKPDLVIFLNASENTPAIRECTSRHIPTAGIVDTDTDPRLVTYPIPANMESLRTAELIISTLSIAGQEGRRLRLKEAERKASQARASRGRRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5T6</accession>
    <name>A0ABR3C5T6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617264.1">
        <property type="nucleotide sequence ID" value="XM_066755363.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987656"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="300" mass="34727" checksum="4EF5614DB2DA3018" modified="2025-10-08" version="1">MELPCHIVLTPTSFPIYRRRLLAHLSTHAPHLASHLLHGPAEPYRKPQDSLVHLVEAALFRPYAQLAGDQPPCALVSTTGFKVWGAQLEEWDEWARNERALREVFKMTFGREMWGRLGRMWCTKEIWEVLESEYMPSPIERQSQIVHYLRSTRLPSLATQEDMLKLWETFNSLVIEARDAGLYMKEKEVVDGFLTAIGGGNLAESVKQEFFGLLDWVVESERWRSLRRVLKRRRPPILLVEAPEDIHSPDEMDEGSSCPTRGRTVLAEKDLNGQNQTMERLNQCDRTEHQRRDSLDVILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C645</accession>
    <name>A0ABR3C645_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617226.1">
        <property type="nucleotide sequence ID" value="XM_066755325.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987618"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="27491" checksum="49F9CD018FC4AAF7" modified="2025-10-08" version="1">MSTPRKIAVILGAGPGLATSVASLLTPTHSLVLLSRSLPGSLSSLPLPKIDPSNILAISSDGSPDSLKTAFEEMDKKWPDAKVDVGIYNVNAKFDLRGFLEKSEADLRTGLEAGVVTGWNFAQAIIPRFLANPAPSTLSSQDKASREARGTLLFTGATMSLKAGAQFSSLAPGMFARRALAQSLAREFGPQGVHVAHVIVDAVMDTPPVRQWMGEDKDGKRMKTNEAAQVYLDVINQKRSAWTHEIDLRPDVEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6C5</accession>
    <name>A0ABR3C6C5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617163.1">
        <property type="nucleotide sequence ID" value="XM_066755262.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987555"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="202" mass="21924" checksum="5C8584398662059B" modified="2025-10-08" version="1">MPHNEYLAPNENKSVPNYWDDEFTKYFSDGWSYPVASATNPSRDSESPRLTKPIDWSKVLSKEREDKAREETNSSAAPGPAILSQQPSLTETSTSQKNVSLLVPVPSDPTLEPSTLTTQSTMSQLESATVAPFQTTTSSEIDTPKPVPAPSPASVDTEKSGTMNDPQPVTRSTTDTAVANSTAPDINSWTPIPFTIKIVPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C8Q3</accession>
    <name>A0ABR3C8Q3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100658</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617126.1">
        <property type="nucleotide sequence ID" value="XM_066755225.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987516"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="534"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="667" mass="72482" checksum="D6C1406EB0959132" modified="2025-10-08" version="1">MELYMYTPPVYMAPIRPLVKPAPSVPIVKEGPIPELFQAPEGEYNLADPGSVFPVLGNTSPNIASELRLAAQPGPFLGGPGFGLPPTPQQTSPSAASASSTSFGATLINGKWEPIYPTRMSWVMVQFPSKIGDRGFGGLLGKSGKSDTAAFLPPAAADGRYPTKSSYSSSSSSSSPVPSEPQSVPFAMSPPTTQSKWPFAKTINGIPRPKTSMRNSTSDFVQRVIGLDSASKYLAEKGKTISEVVKWGCWHMGKQWAWADFGKQTNETDKKSKETLVKVLFSTPLTCTAIINQTAGVDRLDVIIGFETGDLVWLDPILGRYTRLNKNGVLNSSRVVGIYPDPRQPTHFLALFADYTILRFNISLEDPLNAANITSHPWDVFFDRLLLSTTNEPDPSLSGDSGAGRYLNREQGVELLKWKNEDWVAGAEIEKSKDKNAIVFTGRNPVAALKIGSAQIKALAYSPDGGKLAAVSSDGLLRVIDTSEERITDTFSGYYGALNCVVWSPDSRLIAAGGEDDFVTLFSIGRDARPIARCQGHSSYVTCIAFDPQSNNPSSRAYRFVSVGEDGKLLFWDYSPAAVHKPRQHHPNNSVQRDAAASSMTVNIMDHSRSHTPAERTSGRFHAAPSRKSVPTLQPIMSKTLDFGCGPPQDHPLEQHKISSLTICKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHM3</accession>
    <name>A0ABR3BHM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610714.1">
        <property type="nucleotide sequence ID" value="XM_066761174.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993608"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="85" mass="9436" checksum="2C574A7C7079C345" modified="2025-10-08" version="1">MYASMTISIHFVKPENLPNNFTESASLQDLQLSLGVSIADFYTLRISSHPTEKQHLTTIVFVLLRILISGSIGVAQLTEEPSYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHT2</accession>
    <name>A0ABR3BHT2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ferric reductase NAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610776.1">
        <property type="nucleotide sequence ID" value="XM_066760951.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993379"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="133" mass="14670" checksum="34F38F114B25BBA8" modified="2025-10-08" version="1">MIWSVRRKGCLEWFNDDDGSFDRTNLIIHLTGPNTNQTSAVAAPPEEKYMSRGNENSKLLELEATTSTPSDKEKLFDTISESGVNFGRCNISKVLREYAEELGPGERLAVLVCGPVSMLADTANAVAKLQFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIE1</accession>
    <name>A0ABR3BIE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA-polymerase II-associated protein 3-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610844.1">
        <property type="nucleotide sequence ID" value="XM_066761019.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993450"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051982">
        <property type="entry name" value="CiliaryAsmbly_MitoImport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984">
        <property type="entry name" value="RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984:SF1">
        <property type="entry name" value="SPAG1 AXONEMAL DYNEIN ASSEMBLY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="7">
        <location>
            <begin position="290"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="384" mass="42098" checksum="2D9FE42D9C2FD328" modified="2025-10-08" version="1">MAVQVDIPKSEASRAEGNTAFKKGKWVEAIGHYTNAVIYNPEDPVAYCNRAQAFLKLDKYHDAERDCTSALTLPKGRNNIKALYRRGLARKGLKKVEEALSDMEEVLRLDKSNAVVKLELDELQEMKIKIDQEKKKPPRRPLTPPALSKSLPKESSNAPKSKNASDLTNLTQSLELKSASQFPEEKRETSFAAMRKSRDGKKMSFASESSPQSSTQTPDRESAADAALSAIFPPTKPRVGPVPESKKLAASAIKANPTPSSSVLPPLPSSLDTTSTSSGAGLNLLRYFTSSPTYNFSLISLYPAENIPKILDTLLEPDTLGSLLLALDEGANKGAEWEKQKVKKIMEGLRQTKRWKMNIGMLSMDEKKAGENAWKSCGGSGSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIM3</accession>
    <name>A0ABR3BIM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611045.1">
        <property type="nucleotide sequence ID" value="XM_066760773.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993195"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="143" mass="15693" checksum="20060A102B0C8CF0" modified="2025-10-08" version="1">MGNIISAIAGAINAVISAIASFFMAIFSGIASVLVAIWNFITCSYMINISSPDPITRILYTPSLPPLTSIATRLRIYIDKYNFCSNASMIYVAVLGYDMQRLNFSITLNSSPNTESIPKLFLNKRLGWPSACVNLPSILINYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ07</accession>
    <name>A0ABR3BJ07_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611172.1">
        <property type="nucleotide sequence ID" value="XM_066760900.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993327"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="190" mass="21480" checksum="8917F5B6A5276341" modified="2025-10-08" version="1">MSNLYRYDEDEDDPFLKGIVNMALGDDEQCLFPRKPKRQVPLNLTTVPSSHRLEAPTTTRQSISIPQQQTGGTESYWMQPSSMTTLPGHWTSAYRQTYLPSNVNVKVNIDISINTTIEDGNTWPISSQSLASPIRARVTGTYDLSSHHSAIPLIPSNDVSWHTNTTLARRTNHHSYLWVASTLIFMAFWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ28</accession>
    <name>A0ABR3BJ28_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106398</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611099.1">
        <property type="nucleotide sequence ID" value="XM_066760827.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993253"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="182"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="260" mass="28130" checksum="F14803C1E8A2D1AF" modified="2025-10-08" version="1">MSWLLSSLPSWSRGPAPSEGVVGKTTESTTNDQAVDGDNGLDAPPPFPMLNSHQRSKSSQSSSYTSPTAKADPPERTPVPTLSFAVSPPSPTKSAEEEPSNLNIAIIPDNIPIGDMAPPPSTVKKPNFGIQPGGEDKAKGNEKSEVKTKKKRGKVALTPGHSPLDWARLTSSGRNLRGVTSFQRVTPAELKEHNTPDDAWSAFNGMVYNITPYLPFHPGGEEDLMRVAGRDGTRLFMLTHSWVNLDFMLKECLVGMLVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJI4</accession>
    <name>A0ABR3BJI4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF1740-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611336.1">
        <property type="nucleotide sequence ID" value="XM_066760575.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992983"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="619"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0241954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1253" mass="143343" checksum="C017977054528F88" modified="2025-10-08" version="1">MASPPSFSSFPDLAISQPKKAETGPSQNSAPSFSSFPELEPQARRRRSRSWSKERTRDDEGERRRRRDKERTSEKGTDRDNRKRKEKDESRIRDERRREKGSETRQSGQWEYEEDRKERRRGREEEEGRRHREKKKRKDERDHSAERRYKEERRERERKQAEALVRGDVTVPQPTVAAVEPVKKEDGWIKEEDGLPWYETLVKTSRKKRYEDLDDPNSSSNFFVDIAGDRDILRYGSSSSFSAPKYYRDGGNRIIGYNEGLRIVNSRDRTEKGIEVAPKGRPYVPRYNKQTKSAISHLERILLRPSPQGEIDSHSDFLAFEVRNRHRQEESDIPEYRNITRSVQEDNDDQLSILHSIIGEFTTMEQEVRKRTSWMEQHLRDYPSDVERWIEYSRLHLKLSPNAERAMGVTDPAMLPTTKAQAEITLSILSRALKAASENAYSERLHLAYLRAAETLWPADKVTSRWKNVLRELGEQSGKIRGLEEGMMEIWLGYIEWREGQGFGRGDGEKGKGESIDEVVDVYLECIDKLKDKAGNGGSLQAREENAVYLFLRACLFLKQSGHGERALSAFQALMEITFFKPDPLRHIPPADQLTAWWQALIGQFETFWDTEAPRIGESGSVGWRNTPPGTPPPPSRPAPSFAHTSSDPFERWLEAEMSAEQAYALPGRVRDLDPATEDDPFHVIVFSDISPFLFPIFTPEVRLQLIYAFLTFLGLPFTPPEVPSTSPANADPHLRWTLVENRSARQAFWPPKQSIKRIAWQTVGGEPMEPERKRGMDDPFGCPVKCWAQDRETLFGRKGAWYRDVEALDLQAIDVELVRSVFKLLRPLVPDPSFTLASFALEAAVSPKSAVKAAKAILASERSNLLLWDGYARIERQRGNVSAARTVYATALQAASQEGGDGPRSEDEMDLWAGWAEVEFEADERERCLEVLVMAAGIASERLAEHINPTYSPIPPSPINILKSRQYYHSVSTPLSQSHLLLISLFSYLLDGIHTTRDFLVQSSQTYPPSSAESEESLQLLTRILYHHTTRHSTPPALTRDVLEYALSSFPNNTSFLSLYMYGELGSKVYRRVQRLIAQITSEHKDGGVMKGVIGHLWAVWAEAVSAHRTFWDDGGGGAERVRMALDKGINSTGGRYSAALWMLYIEFEALMGRHQTAKQLCYRAVSTLGGCKALYLLPFSLPLRPHFSTRELKEWAELMVERGLRLRIPFELFWMAEEEEGSERAIVLPEDEVLAEDELRFLSERQALKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJK5</accession>
    <name>A0ABR3BJK5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610945.1">
        <property type="nucleotide sequence ID" value="XM_066761120.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993553"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="92" mass="10326" checksum="F9B487F25A1CA3A5" modified="2025-10-08" version="1">MLRFSICRIGTPELLPRTKHRRVQLIDCCQAHTADSYVLQEKGSPSDIVDCLEKLRTGAAGNFVSFIRIYTFSTSLPASLTNHQMVLGENQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJZ1</accession>
    <name>A0ABR3BJZ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="5">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611487.1">
        <property type="nucleotide sequence ID" value="XM_066760183.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992588"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0242105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="534" mass="58141" checksum="1F50EB0AAB9DE6C7" modified="2025-10-08" version="1">MPVFSMLMNSTENYQRRFDQIARAALAYWVLKYVLLDGFRHVKAKGLCGTVDEIKNSIKSLVVRVMLAFPSNKAKLNSELAKARAELKEKLAPSQYPDGVRLTTVKALPETGRGREWLESEWANLKKLEKGDVDNGRVSGAVYHGGDELNAVINEAMAKFVVTNPLHPDVFPGVRKMESEIVNICLNLFNGPNGAGTTTSGGTESILMSVKTHRDWARVTKGITRPEMVIPSSAHAAFWKASEYFNIKLHVIAVNQETRKANVKAMKRAVNPNTIMIDPIPELGALAKRCNIGLHVDCCLGSFIMPFLEKAGFGEGIDPFDFRVPGVTSVSCDTHKYAFCPKGTSVIMYRSSELRRFQYYVITDWAGGVYASPSMAGSRPGSVLAGAWAVLNYIGADGYTSSCRQIISAARYLTSSLRTLFPDDFYVLGDPMGPVVAFNSKTVNIYAVGDVMSKKGWHLSALGGVGGLHMAFTRLSAKSVDKLIEDLGEALKEVKASPQGSGGDMVALYGLGQTSAGPHVVGKLAETFLDTLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK02</accession>
    <name>A0ABR3BK02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610899.1">
        <property type="nucleotide sequence ID" value="XM_066761074.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993507"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="824"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="707"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="756"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="922"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="953" mass="100162" checksum="03822638BCFE15EC" modified="2025-10-08" version="1">MTPPAHWQTISPQTRPLTLTVLDLTPLALTVSLSLTPSASIPSLHHSHTSHSHHAHGAHGHPHTPVSHGLTSQATNQKNRKRHRKRGHPNQISATSIHGEPSEDDEHEQEESDSTSHQDSSVSFKDLLRHGVLVYVNGQQSNNLFANVMDDEDEETEWEDEAETAPHGEEIEESMEQGITRRRPRKARFMTSAAEAAGRVTGKKKDEKPHSKGDKDRAVLVIYGLMPAQEYEIELRVVGMGGQENEALASTSVLIPAPPTPTVCSRSRANSLRSRSRPRSRSNSLTAPQAPEAAPDAPPSPTHAETIVPTPILNAVDTQAAQLRHLIATAHTEKELLQTQIKEARRTAQRGEAALKAEIETVKKGIEKAGGMDLRAKQKALALQEQVKQGWAGAEAAEKEMKAVEQGLTDLEKRLEQVKEQVEEVKKEFKEVKKEEEKAKESDKKTRSDEDKKLAEIISKIEKLKTKKAKKEAEGAELEKRLEELEKEMEEAEKKNEEEKANRSRTMSYYATGYGHQHYDSHDPTSFGPVGALPPPVPGSSTSQNTNRPLSTHPSLTNLSGPYAAGPAYRPKGTPGYTPRFPSGGARPSPTLPSPTQTTGFYSSASHPVPPAPVNVSPGFRPSKVSPAQGTSSTTRSGVNASALPFHPPTYNSQPGWTASSSNPPATNPTPPGANNTPPAEHTTALMPPSLQHRIYLPNPRARPFQAPSAASPTITPSSAPSTNQSNPAVATAAAVASSSSSNSNPSSPAFPPLPTSSSTSNNKSTSAPVSQQGPSLASIVTRAVLAPTSVLAQKSSPSGGIGLPGSGSGVGIGPVDGVGRTGSPSGSIAGAGGIPGARTGTPPIAHGHGMGGLVKRGSYTGDFPPLSPTWSGPGPIGGTGATGTAAGPNDGVDRSQGMQSSGSGTVTPGLTMREGMPPPHGGNGGNGNEKGGNGNGAWGKEGIVTGAILKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK03</accession>
    <name>A0ABR3BK03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SYO1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611498.1">
        <property type="nucleotide sequence ID" value="XM_066760194.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992600"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13394">
        <property type="entry name" value="Syo1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="4">
        <location>
            <begin position="462"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0242116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="737" mass="80262" checksum="C3DD04F27489E209" modified="2025-10-08" version="1">MGKAQVKKKTQGWRHNPVRVPDSHLGSGKAEGRADPQKEKQMLPILNKLKSPEYADRTWACAAISNLIQNDAATRRLFQGKNVVGELIERLSDSVDEVVVEASGALRNLAIDGGRELCGEMANKGIISHLGVLIGKISNTITSVLSTETMNSDDNLQARKHLLSLSENVILLLWCLAEASPKTLANVNAMGCEGLLIMILEAREKLGLGVSLAAAQTLFALSQDNFPFRKSLVIHPTALKSLITIAQEDHIPAENAQKAKEASRKSKSNKAAAEPASEADDLPDGRALLRRVLVCGILRNIIRAGSRADEKVGINALTASTILPLINGLLDVKLEDVCTRVDKLVKEIPSDVKILDKNAKTDHKSISEVALDRIERNLSTIVAALEVLTNICAGLEDEEDIAAETLEEGGAAAEVEIEEDVDAAMDEDEIDDEGLISMGREPGAELEMETFDSGVKLNPGATLSHLLTNLHLPERLTRLSRPVSLSFPPASTVPSIHPPTTSILSILHLHALEALNNLLLTAVASISAADRSAAAQIVASVPAQGLWDSLFAIIQLIGSEPQALQMKGQEMRMEVLEMTLGCVWGTIKINPSVVNVQEQQVQILMDSINVIKDEITKTRVVETLSTIAMRESISNAENRSISQHLVQRLTSTSPFPSAEMLVSLLNAVIDIYSDETRSYDSVFVEKGYLQVLSGIVGKVRAEVKKIDKRRERNLRTRGDEVYENLVAFIKYRRSLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK35</accession>
    <name>A0ABR3BK35_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TATA-box-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611537.1">
        <property type="nucleotide sequence ID" value="XM_066760233.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992639"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0242155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="232" mass="25486" checksum="4911CB45D77CA5BA" modified="2025-10-08" version="1">MSGLALPKASNAGPSGSNSKSEERQMLDGEGSVATRPPQKAVASVPEITAVDGLVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPRRFAAVVMRIRDPRTTALIFASGKMVVTGAKSEDDSRLASRKYARIIQKLGFEAKFAEFKIQNMVGSCDVKFPIRLEGLAFSHGAFSSYEPELFPGLIYRMLKPKVVILIFVSGKIVLTGAKVREEIYMAFNQIYSVLLEFRKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKC1</accession>
    <name>A0ABR3BKC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611579.1">
        <property type="nucleotide sequence ID" value="XM_066760275.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992681"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0242197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14997" checksum="FBD9537DBBC29DD4" modified="2025-10-08" version="1">MSDTKVAALQAQLQSSTISFQKIENELAGVIEARQRLDSQLSENELVLKEFKLLKSHNTVYKLIGPALVPQDSNEAKVNVEKRLEYIRGEIKRVEGQLKEIEDKAARKKEEIITLQQQFQALQAPSAPQPSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKT9</accession>
    <name>A0ABR3BKT9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611759.1">
        <property type="nucleotide sequence ID" value="XM_066759813.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992212"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="840" mass="92077" checksum="8F8D353EC4F5B256" modified="2025-10-08" version="1">MRVPYTLQKLNNVRLKSHLYTSFSMLHTSATRSNNTRKSDSYHPFPLPSAINAIPPSPISQLPFPTSPLRGSWSQTPISSAPVASLGQLQKLLRSYSGEKSQPTSASTTGGTLSIQHAEAVWLLYSTLPQAYRRTFPLSVLHQTFRQVVPRYSDIKTLIGNPRTRNPSIVRDHRRKVRKLAAEWEMRLRVVAGDILAPKRNGARQEGENMKEESHTPGVLTGGLRKLSILGDKTGCESILLELKSRFPPSPSSASSDAASSSTPIVSPSKWRTLYDYSLRSIVRWLSLNIYRAPTAQGEILSAISSLKRLISGMQSQGVPAGEQTALVLLDAGRHSSSPTVVQDQKVREGFEDLTKVILEGGYGIKRRDKGRDLSALELGWEGLKVDLPTQVKLAVIEMIGRKGDLWGMIVAFERMYPDLPVSSSPAYSLAPPSASTVRPASASGLGELQEHVTEAEAARANSGSEEVMEEEIPTLSSMMAKEQAERAERDWLGRVRHSGADTPETVAFASANIAGPAESTETVELGSPYRRPFSAYLPSVPMPLSISSFSSHPIYAHADANSIPPDYMIKTMLHYIYLHRHPDPDATFHGGRGRQNVREMGLYVCRVGLRFAALEQVRWLSELVASSSSSPSSFTSDSTSNPNLEISHKRIHPDPLWFNTALRIVLSSAGRNKKAIGKTGVLREEIEGLERRLEEEIEVLEMLRASKAETANLVTGGVSGSESSVDTSEGHLSDITASTSSLTPNTNIHININIDIPTHLRSLQTKLDQLARLKEEIEHRKEVASARKNRGKVRAAEAQALVEAQSAVIEAVATENEMKMNGKEKEQGKEVYMSGIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKW3</accession>
    <name>A0ABR3BKW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_105406</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611807.1">
        <property type="nucleotide sequence ID" value="XM_066759861.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992261"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="12">
        <location>
            <begin position="15"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="11">
        <location>
            <begin position="250"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="361"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="463"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="539"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="693"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="715"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0243440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="728" mass="78733" checksum="E61C35C915810AB5" modified="2025-10-08" version="1">MHPGVLHRRFLNDLSTSLFSFVLPLLPPSEELSVKEEVRCLIEKLIKGLEPSARLLSFGSSCNSFGLRNSDMDLVVLIDDPNAKVDPGNFVESMAALLERETNFNVKPLPRARIPILKLELAPSPALPFGIACDIGIENRLAIENTRLLLTYATIDPARVRTLVLFLKVWSKRRRINSPYRGTLSSYGYTLMVLYFLVHVKQPPVLPNLQRIMPMRPLEEEEVMLDGRNVYFFDDVETLRREWSSVNFESVGELLVDFFRYFSHDFQFNNSVLSLRAGQLTKESKGWVNDIDVGGLNEMARDRNRLCIEDPFEITYNVARTVTKDGLYTIRGEFMRATRILTQRPERAVLALAELCREREDELQRAPRSSSPAPRALSATRGNFTSAHVPGTWRSHSQAPFDRFTPSGVHEPHGRGGDDDIPEYSAQDLWLQSQGANLGGVQVAGLGFGFDDLELHGARGRDTVARGLDTPSGAYRNSPSARRSASAYEGNAVPTSGTISAPLSPQRMYAQLELGKGIGSGLGSQQLWASYDPRLHASAGMPMSMSGPSSLRSQSQQGTSRSVSGPNIGVPASAGGSLRGRPLAGVVPSSSMGIDSSSPLHAFAPFDAAPIPSPSKAVGIPAVAPAPGSKGGPGTAPHRTAVNTNENGTAVNFISPSTLLSPSTCASALPETQASGMRGMDALAGNFGQLNVSETGTISPPPKVTANSRAGIVGEKTEHPDPAVEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL92</accession>
    <name>A0ABR3BL92_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611563.1">
        <property type="nucleotide sequence ID" value="XM_066760259.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992665"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03234">
        <property type="entry name" value="ABCG_White"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF91">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="696"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1101"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1139"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1178"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1218"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1250"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1330"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="97"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="757"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0242181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1357" mass="149699" checksum="B164B008297943EA" modified="2025-10-08" version="1">MQPGPSHNVEDLELVSIHQHIDLTLVPTSQLTNPLFLVEPEEQERLHRENEDWRKNTLLNLPPPLPYDLAVEKLTIGVPDRKAFPWIPNLSGVFAKRKKKDEGEPERQKKKWILRDVSCECQSGEVLAILGGSGSGKTTLLNAIANRISGLPTINGEVAYYSAERYEGLKRGMKLKKGQVKKCIGFVRQQDFLIECLTVRETLAYAAKLRLPTHLSDEAITFIVEQTIDELGLRDAADTVVGGPLRKGISGGEKRRLSIGCVLVTLPSILILDEPTSGLDAFTSYLLLLSLSQLARRGRTVILSIHAPRSDAFEIFDRIALLSKGKIVYSGLRKDCLAWFYSLGHEIERGVNPLDFLIDVSSVDNRTSENEEASIARVLSLVQAWNTRSPTHWADNLEKASKRSSTSSISIDHLSSQGNNRAEVSSNGIGEDGTSRDTDARDEQRPGLWKQTKVLTARAHRNVYRNVPQLVGFAIQAVLLGVIIGITYYQLPETPTGIQSLKNLSFQLIPGVFYLQQVFWIYKFCTDLVIFDREREDRLYDVVPYVISDFISYLIPSILSPTIYVALVYFISKLRTDNLAANLFISIASTILVQFTTQGLALLSASLLRSFSAASMLGNSLNLFQIMSSGFILTNVPVYVAWIRWISSYFYSFRIIATTQFKDRVFDCPAESNANLNQCLGNNVLNGLDFDYTINIGAWFGGLIGLAIIEYALACVVLWGLPVGGVKHASEIDSHHRGKETDVKESHMTRDKIDVSVRNLSLIWKRRGRGSLEDREKVILNDLSLDFPAGEVSAILGPSGAGKSTLLQLLAGRKLNPGPLSHFTTLGTLLFANQPTSRTTQSNVAFVEQDDDWHLPSLTVRETLTYAAILRLPDKMPKKQKIARAETVLRMLGLKDCADLPVGGALLKGISGGEKRRLSLAVQMINDPAVLVVDEPTSGLDASIALGVMHVLRDIAATGRTVIATIHQPRSDIWKLIDNVTLLAKGGTIAYTGKRSDAVQYLTSINHAMPSEFFNPADHLLDLVSIDPRVSYHDQSLTRVNGLTSQWRIKSAGHESGNEQERNGPDSAIIKCGEGTTPMRIALPVVLERHWKNLWRRKDVFFNRLVQTPLLGALFILFFQRLTHGPAGAQDRIGVTIESTSAIAFVGLLNAMSIFPADKNLYLHEAKSSARYSPATFVITYSLVEVGFELLGAFGYGAIMNVAIGMQTSARIYFEYSISIWAMVNMGESFAMIFGSWIQTEGLTVTIVSTILSLIGQVSGVISLSVPAWLAAIAWSTCVKPATRVQIINEAVGLVFHCTTEEISSGACVAQNGEQLLALFNWHDLDTAKFMGIMIAICIGWRIMAWASLAARVGGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLA7</accession>
    <name>A0ABR3BLA7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105536</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611936.1">
        <property type="nucleotide sequence ID" value="XM_066759990.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992391"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06629">
        <property type="entry name" value="STKc_Bck1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1488"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="440"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="540"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="602"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="889"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="966"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1177"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1247"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1317"/>
            <end position="1452"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="111"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="118"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="177"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="467"/>
            <end position="489"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="509"/>
            <end position="519"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="550"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="602"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="657"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="677"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="690"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="735"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="763"/>
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        </location>
    </feature>
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        <location>
            <begin position="782"/>
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            <begin position="819"/>
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            <begin position="842"/>
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            <begin position="936"/>
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            <begin position="976"/>
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            <begin position="1024"/>
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            <begin position="1072"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="1108"/>
            <end position="1118"/>
        </location>
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        <location>
            <begin position="1130"/>
            <end position="1142"/>
        </location>
    </feature>
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        <location>
            <begin position="1338"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1350"/>
            <end position="1360"/>
        </location>
    </feature>
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            <begin position="1364"/>
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        <location>
            <begin position="1428"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1517"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0243569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1788" mass="195764" checksum="76C66BB60CCCA455" modified="2025-10-08" version="1">MSHHPQLSVSTGSAGAGPSTPTLPRRPQGARRRGVLPGLFIANPDNSDEESSPPKAESQKSPSGVSPISVSSSSGKGDPSSVSIPPPESPSHSIRERGSLPYPPLPAPRSSPLPSISAFPSPQPSISTPLPAPTAYGHAPEISSGPPQPPPQPQRHLQRAFTTPVPEHSPRPFPEPHSSSTGTTSFHQQVPNSPSRALPPLPSPITRQSTVPSPVSPAHGQPYSAPPAYHPHNQTRVASPDDAISPATGSEHGSIMSAGIGRRNRSGSVQGQQVRLQVTTDNEAFHLVDITGINTAEGIREKVFSKLRIRDEDYPTLSMYRTEIGEPADETPILPAALLNICRTLGDSRASLKFLVKQTDVPPSSAASVIPPVAAQTDYHPFRAAADLRRAGVPPITTDLSNPVLYRVSSRHSKEGSLSSASGEMLNRGELSASDWSDLGHEAEDWSEPGLSRGTKKSVLQNAGVRLSTSTGGSRSPVTEHSASLGTSSPALPTPPIPPHSVSLQAGEPSIHSSPSSRPSSKHYEFNEFSLPPQFDHFKPSNAVSAFPPSGTSISDAYQNENATAGPSRPAMSQEQGSQGLGLSLDDDIDPETRALIEQFQREEQEAQRKEEERKRQLEADEELAKREQQSERELWEMMQQMQKEQRQREQAQIAEDEARARQVEEEQRQEEEQRQALEAARAAWEAEQLEQREQREQREQQESRFHTFEKDRRQRQQFFQNRARMGAPLGDSTAWESTWMVSPSTEGSLSSRRPSEGRLPMVQTSAPRTSQTQSPALPPRQTSQPMYQPSQSQYLPDFAYSHRRPSGFPNTPYAETSHAQERLHDPRLQQATGRSPAPGQRGQTSNTPRPESQRIRHPFSYAAHELSNEHLQTPALSTTRSVDNLRMTSGPLGMTSRQSQVYGPPRTSITPAPGFAEHRNIQPAAASATSYRSPSSDRARDGRYPEPLHSSSRGVATMAPTAIDTGLVPFPSPHPNSTTSSASWRSHPQQFNSLPRSARGPTFDITRPNTVHYDRSPPPPTSPETTIPPRRPSTYYDDVHVPDTARTAIEDVATVRRPSSPFPWGGRARSGSASTPYRTQSPVPVEQPRISEASGFDDTESQLPYAHNTSPRSSWLSVSRAGTGRSDSDTLSVAGTVSSEATVRPGKGMGEDNDTNSGDTAKAGQWDRHLQEMIAKMGPGNEEGTLRPRKEEEEDEATLFITPPVRASETAPSGASAIRPSPSKPNLIVNTASLSQQAYHQLNPVLSASTPSDSATESESTGEGDGEIEGSNLKRGKSFARPRDPNQWNFRPEPEQLYENLDRVFPQIDLDKPIVQGAESTPSTPGMESPSRVEIIGGLPLPAGAAPGRQGGPQAGSGPLGRAPQAGGPPSAPAGGFNRSKFNKAENRRSIRVVADHKRRTLQRQISRHEDLPPEYDVGAEEVNSVMDDRVVNPRSDEQRKKENRRSSSMWDHKLVEVTRFARAQANREADIPESPASDGKPGTVNWVKGELIGKGSYGRVYIALNVTTGDMMAVKQVELPATEIERHDSRQQGMIKALRDEIELLKGLEHKNIVAYLGYETSPEYLSIFLEYVPGGTIASIYRTPNQARFEPQLVRFFTEQILEGLAYLHSKNIWHRDLKGDNILVDAQGICKISDFGISKQTADAYDSFGQATNMKGSVFWMAPEVIHSYSERSYSGKVDIWSLGCVVLEMWTGKRPWGDMEQFAAMFELFNKRSRPPLPPDIVLPSVALDFLNEKCLATDPRNRPMARDLLQHEFIKDKDLTWTFKDSKIGKAVAKRGAKRPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLC3</accession>
    <name>A0ABR3BLC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105563</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611963.1">
        <property type="nucleotide sequence ID" value="XM_066760017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992418"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="15"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0243596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="512" mass="56539" checksum="D00EFF11B91AF17E" modified="2025-10-08" version="1">MPYLGLRGNSLLFAISATAGMGFCLFGIEDSSLGGVISSDPFQNRFHLDATGQGAVTGCFEIGCFFGGLAFAFLGERYARRIVLFIATVPLLIGTVLQVATYSTGQLAAGRVVAGLGFGAITSALPIWQNETSPAAMRGMLICASLSMLIVGQLIAYWAAYGLLQVYDDDRVYRIVFSLQGMAGIIMAFMLIFMPESPRYLLAHDKQDEARQVISALLDLPEDDPAVIGQIEEITQAIELEMASAKNWRDLFKSAHDAQGEKRRMLTAVVIQVCQPFSGSTIISYYLTTIFQEAVGLTSHTSALLSGYLQVWFLFASFGTWYLIEHAGRRNLFLVTAFFMSAVMFIMGGLLKMDTKSTGIGAAAMIFAYQGFFTWGWMAGVWAYSSEICPLSWRSKGMGLAVALQWLFDFVLLMVTPIGISNIGYGMFMLFGVFNLCFIPIVYFLCPETAGVTLEHIDEFYGPGKNPVKESSRIRKEMKEARKRQEDELERQEVAVSVMWEEKGKVTEVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLQ9</accession>
    <name>A0ABR3BLQ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611713.1">
        <property type="nucleotide sequence ID" value="XM_066760409.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992815"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="8">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="423"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="701"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="623"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="951"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1138"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="957"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1030"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1157"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0242331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1271" mass="143221" checksum="1E4602296A5DFE40" modified="2025-10-08" version="1">MSASESQIPAISSSGGRASHPSSPSSTANIASTSIPSAAERQDGIPHSPTNIPEEAVGSTISAITSDTTQVPQNNQVLTEDLQQPPVPERHANLERSTRLQSSEVKEEAQEIEEGPKFIQPDHFSPLTNNLNGSGAARGIPNIGDGWLSPEDDPHALRGIPVFKPSMEEFIDFEGYARKTTAWGQYSGIVKIIPPVEWIESVPPISKSSLASVRVTDPIQQNLIGSSGLFRIANVVRNKRRPLTVEEWFKKCKDKKFSGPGPKDVGSITNRDSKEAEERRQKVRDDMKKEKERRREKRLAAEASRVRKATEVEDTKEEKEVNGKVQPVPDRKDEASTDSVNKPQELQSASLGPDPFTKSIIVEKHINPWYESFDPKEDWLPENTRREDYSLEACVALERRFWKNMGLGEPSWYGADMEGSLFMDEKTPWNVAHLPNLLNRWDLRHLPGVNAPYLYFGMWGASFAWHVEDMDLFSINYIHFGAPKFWYAIPQQQAERFERILQGYFPEDARNCDQFLRHKSFAVSPYRLANDGMRVNMLVHNQGEFVITYPRGYHAGFNMGFNCAESVNFALDSWVELGRRAKACQCVNHSVRIDVDEMLAKDAIRFKGEEELLNAIAEERNKKKQRKRLSVGDDHTPRKRAKQDSQKPPGDTVLSHTPAIIEETDQSKPVRAPRKRISKAVIDISSNQQPAKADLFKDPNSFPCLFCPGFAKDDLIPIFDPSDAVKARWKPRHGEIMAHHSCALAMPGVGIEDREIPGGFGTFIVGVENVENARWKLKCLLCKDKKLQKTGAKIQCTKGKCPRAFHVSCARESDVASLKIWEVETPMLSGEGEPPLPEDAEIPMMIDIKVELLCPQHNPEVKEKLEQRKAEAFRDRVMSIPPGSKIKIKVRTGASLEYILIEARETTQQVYVQDAEGVGGIFPWSSIDLRPAQGPLLENEYARTHVNTNNRRHDQMNGASSQGDQSDAQRHLALQNKRSAQPSHARPLRMDEMLNPSPKKSKKLNQASGLARRESVPEPAPYNSYPPHGSGHHPKHHFHVHSAGHPEPFAHHPPSQFSTPLPPLQVSHQMSYQLTHPVLHHQQHQAVPQRVFHRQAPSKEHQPLYPIPHPQVSHHPHHLVPPPSNTYQRVASHLALHESQYSRRPSSVPVLHHYHHLPPPQPSYPHPRYPMPPQTHYSSHPHPHPHHEPHIQSSTLPPPRPPAPGHLVNNQAGNPSHPHHQMHEPYRRHSAPHPMLPTHFVNPVTTEQSRLWNRKVSAPNGAVHLPVPDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLT9</accession>
    <name>A0ABR3BLT9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome assembly protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612125.1">
        <property type="nucleotide sequence ID" value="XM_066759478.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991874"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="36662" checksum="0F35A9313588F6A3" modified="2025-10-08" version="1">MSEDSSASTSVSEDESSSSSPAASSKPSNSGSPARSSSQSRSSRSEDDSRSLASSLRRISRRRGRGRSGVKETRTKRRNTVHLLPQAKIGTSTMPDEKKEENTEVTEDMGGSSVETKSEETTATSSGPSPSPAASTPTSTAISEPSESNDAYGTALHSLSTSIQTLSFIDPSSTIRDLETGKRYQEMFDKAQKDQAGVYKKLMDYLDKKAGGTGSVEVENDGKGAEEKETKNEAPIAPAPSSPSSEPTKSENAPPTDTKTEITTCALPASSSSPPEDNKPTGPSPPPATTATATEEKSGKKANDKVEIARKTKPKEEKESAPVSSTTAAAMSADGEKKEGKQADSKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLY9</accession>
    <name>A0ABR3BLY9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GlcNAc kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611280.1">
        <property type="nucleotide sequence ID" value="XM_066760519.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992927"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052519">
        <property type="entry name" value="Euk-type_GlcNAc_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190:SF3">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0241898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="57181" checksum="92E8C96E26F790A1" modified="2025-10-08" version="1">MLQGSISVLVSDQPTITGDQVSDVAMPARLPTPPASPTVPQLILCADGGGSKVCVVVRSDDGLEVRGTAGPCNVQSGGYTSATQSLLLATYRALAQLPRSHVPPDLLMPFIDLSDSSRSSPQLQAVSMLPRDQLLTPPSSVGSKTTAIHNHLPSVMNQLTLPRSSSPSTSHLSPTPISLTHLSPHPNFATPVGKPISTPHTNNPTPRMRLPPLNVPVFQYAWLGLAGISSKADEDAFGKVVCGALRLDIERVKVSNDVNLLAAPAIDLPGIDHVIALVAGTGTVGRVIKVGDKKRGLPLEDVGMSRGWGYLLCDEGSAFWIGRLAIRALLSLSDRHASSGIYSTPPPPFLSLHNDLLAYFGTSNPLDLINIASLTASGMVEPTESVGEATSRRNALLAGAARVVFKHAFPGDVSPRSGLPTPPGSADGGAAADMDSDHGSTSSREQQEELKHDDALDHASHLEALGLARQAAAPLIWLTLSLLGDRTIVKPERSALTLGGGLVMSEGYREMLLDGLKKEGVSFGRVIVVGDAAGEGAQALGRVEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM13</accession>
    <name>A0ABR3BM13_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA ligase</fullName>
            <ecNumber evidence="15">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">I308_105095</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IND107</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="15"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612200.1">
        <property type="nucleotide sequence ID" value="XM_066759553.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991951"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18435">
        <property type="entry name" value="BRCT_BRC1_like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17722">
        <property type="entry name" value="BRCT_DNA_ligase_IV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 15 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="18">
        <location>
            <begin position="383"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="700"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="969"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="824"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="824"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="852"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="898"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAL0243833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1080" mass="124083" checksum="A25B8B81CC1062DB" modified="2025-10-08" version="1">MAVHAPYHHAPPPTQEINGEKPTLAAATTLERPADCINRGQYPAFYIICGYLNRLRADAPHKKYELLMRIFGNWREKVGPDLYPLIRLLLPDKDRERPVYNLKESMLARCYIDILSLEKHSEAAQRLIKWKHPAEGSSNPTGDFAKVCYNEIKARSTVEEGQLSVEAVNMLLDKLAVGKMKQAEYVPILKAINMQCTAEEQEWIIRIILKDLHISIRERGVLSAFHPDAIDLYNICSDLKRVCWTLYDPGFRLNKNETHLELFHSFVPQLCGRMNDASLENIAKAIGAPKEFIMEEKLDGERIQLHMRGNGAQWFYCSRKAKDYTYLYGAHPGEGSLTRFIANAFQDNVRNIILDGEMMVWDPVVGRYLAFGTLKSAALDHFNDETAPRPCFKVFDVLFLNDHCLSRKRLSERKRLLHSGKIFKNIEDYKGRLEFVEEKRGKSAKDIREYLERVVETKGEGLVVKKTDVIYQTNSRGYDWIKVKPEYSDQMGENLEVLVLGGWWGKGGRSGKISRLLCGLREQTFDDGTVEQPSFKTFCSIGSGMSYSDYEWILNKHRKHWKPFDRSNPPAFMKLGPVGLDDKPDVYIEPENSFVIEVKASEIVPAGGGYGIGFTLRFPRCKYIYYDKNSRDYELDDESKERDMWTCMSVDDFMDLFSRPKRSYDDSQGPGKKKKRKVVRSKKNHIITNFRGQKLSDIDVETSIFSDMTFYIAKGTSEYPKADLEALVHKHGADFTQAQLSDLSAIVISPDQKSPLVRAQIRHGVNVIKPEWIFESIARRKALPLLKEFLVYASEEVQEGRYYNKTLEQYDKVSFVRDRTGETLFEEDGDADVEDEVMDDEDKDETDMEEAQEAKDRRMAKEDLKERESNRSLEQKKLQEAWGLRSRASTGGSDSEAEEIKSLKEESDTDSERIRRLRAIYQDEKDEENDSHESDVVVDGDDYKLVPLNGLNDKEEGFMGESPEAMHYDEDRIFYHLEFYIDTPENAAVNGLESSSPSLNAQERLAKIEKLLAENGGRAVKSISDPKLTHIIMDDEDSGRYVELTRKTALPRRKHIVTPKWVEDCVDEETLLDEDLYKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM32</accession>
    <name>A0ABR3BM32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Polycomb protein e(Z)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612222.1">
        <property type="nucleotide sequence ID" value="XM_066759575.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991974"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="7">
        <location>
            <begin position="448"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="606"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0243855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="730" mass="82559" checksum="5408C004256C8095" modified="2025-10-08" version="1">MPPRQPGGLEPPPKVPPEIHNTVRQTWVQTWKDFYSWKPPSTLPVEDGWMSMRAEEDDKNLVKGHENFSKRMASLMEKFEQESGGELKSAEVEFQGATELKPLQNPNKPPIEWNLHGRSIRPLPPIYKLTPTIEPVPEYSFCIYTPRSILSPDEVIMPFMPTFDDDTLDIPEFEAEKEKYSSLFTNCLWDLPGRDADVDIIMFETLKRLEKLGIKKEDIDKTRILPKECFYVESLDLRRDMPPFPLAPQNINPVAGVKLPDGSKRVVGAKRKWEEPLELIEEDFEADLEGFEEACCHYPTCTSVMCIRHAGMYFDGLTRNVSKGSSFNAGNQRLPRISSVLPTLSEPCSPTCYSLTSNEATLRAGFSSMRLERRGWSESDKQQLIDILSAYDGSGLERICELKAVFSRTCAEIAQQITTILQDRSRGPSVHEAGAEIEYSTSSSTSGSSRPLLQRSRSSKVQLIPITNRLPEFTECEHEGECVPGVCSCADNKLPCGRHCSCPSTCIRRHRGCNCRRILIQEGKPVREGKICINGKCPCIRSFRECDKELCGSCGAAEELVQDEAILKARGKFGKDGEWIENEDKITQGQTFISCGNIALQKAKWPKLRVGISKVAGYGLFADEDIGHHVPVGEYVGEYISEWEGDNRNFAESINKRRYQFTINPQFITDAGFFGNHTRFINSAQGNNVNCVAHQRAVGHELRILFLTTRPIKRHEEIHFNYGDDFWDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMI4</accession>
    <name>A0ABR3BMI4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612367.1">
        <property type="nucleotide sequence ID" value="XM_066759720.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992119"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0244000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="307" mass="31752" checksum="7491EE210E8D9335" modified="2025-10-08" version="1">MSISLPNGTLLAASSSSHLQLSAAVTRILHLANFSAELKTRDLQLMFKEWDNDKGGYRIKWLDDTNALVVFADAIVAKRAYLSFLLNPPPSFTGSIRPYDRPDAAQIIQSLASRALGHRSSMSNAVNGGGAPFPFPANKDPAAPQVHSRAMSVTNIHHSKTGSISGALPGSSSGPHAGGLAAPTQRRGHHRSGSGSSSWARTSLSGGLGGLGGLAGGALSFPANASSRPTLPTHDESSGGPPSRSGSSSSGEAVVLVDPSAMTGMRVTSNGAPKDEANEDRKRRDSISADKALREVQKALASVETQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMT2</accession>
    <name>A0ABR3BMT2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Streptomycin biosynthesis protein StrI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611283.1">
        <property type="nucleotide sequence ID" value="XM_066760522.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992930"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="55"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="3">
        <location>
            <begin position="190"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0241901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="51994" checksum="CA133EE8F4990F86" modified="2025-10-08" version="1">MTAQVQTPRPESTSLFSPASKLTKLADDPESKRPKVNTGGSLQDLMGSKTTKQVTVAVIGAGQRGLVYASYALEHPELVKVIAVAEPRAHRRKVMSRLHSIPPENQYESWEPLFARGRIADALLITVLDDLHAELVSAFAPLGYHILCEKPMATSVQDCVKMVKEVELSGAGIFGIGHVLRYSPYNRAVKEVIDSGVLGEIVNIQHIEPVGNQHFAHSFVRGNWKKESESTFALMAKSCHDLDILSFYLSGLTPVKVHSFGSLHHFKKSKKPAEAGDAKRCLDCAFEKDCVWSAKKIYVDGLKDEGHKWARHIVDADVLDIENVTDALKTGPYGVCVYEAGNDVVDHQVVNIEYEGGVTASMTMVAFTEAICDRGTRIQGTKGELIGDMATFTVFDFLTRTKTRHTPKSLPGNHGGGDAGLSETFFEAVSKSDQNVLGVTPEEVLNSHLLAFAAEQARKEGKVVDFQEFKDKAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNC0</accession>
    <name>A0ABR3BNC0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612647.1">
        <property type="nucleotide sequence ID" value="XM_066759160.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991551"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="481" mass="53141" checksum="DBE361C22BF3A086" modified="2025-10-08" version="1">MATPSSEPFFPKDRKRSAHWSDSDTDILVEVLLRERDTGRTVDNGFKPEVWKEAARLLENRNFVGGPKTPEACRSRWQRLQRDYRLAKEMEVLSGFSWDHNTHRLSASAEAWMNAEKYRKIHLPHYNSLAILCANDSCRRAPRNTKTRHTSISSSSSLMNLNTPNPNPNPNPNPNPPTPAQMVQVPQSVSMAQVDHLSRQHSHSNLPTSGQMAPISTGQHHSHGHPGMHDPGNGNGLVQLGGATLQTDHNVFSWESGEQGSGEGDFDGPFGLPNGSQPFLPQKRAMPFDTSLLNGSSQQHHMIPQGSPPKRPRTSSRPMITHQLSGMHQSGPFGYPLQNTGNPGHLDTGNPGHGPNAGSGNQGDRHSPEFSTSTPAMLNHPLLQTPPGLRIKPYSPPTPGSAPSLTLQTPEMTVAGLTEAQRRTEALLQLQQQETEMRDEDMVEVMAEFEVNVAAADTYLAIKREPLRKMWLTNLVKRRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNE0</accession>
    <name>A0ABR3BNE0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612667.1">
        <property type="nucleotide sequence ID" value="XM_066759180.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991571"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="89"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="375" mass="41582" checksum="208BB3BD65AD0273" modified="2025-10-08" version="1">MPKLKAALAAQQHSAAKLAAKKRAQAAEDAKRASIKASIDGVKKGKKRAKATASKTASEAKSEILEQAAKSKGKAKPPTIPFDKQDTILLLGEANFSFSLSLLREPHNLPGHQILATVYDSEKVTLEKYPDAAENIRLLKEKGAQVEFGVDAGALEKCKAVGKGRRWSRVIFNFPHVGAGITDQDRNILTNQHMLLKFFRSVEPLLTEGPTHMPIPQRSSSKRNGKGKQKGKQKKPSSDDEVAPAVEEEEEEDFFFNDDPTFTNPKIIAPAEFTPPKRAGTVLITLLSCPPYTLWCLPQLAARPPPICPGTNLPQPRYTLLRSFEFRPEIYDGYAHRRTIGWKDGLSKSENEEILGRKGIPRTYEFVRTTNMKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNP8</accession>
    <name>A0ABR3BNP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CFA20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612782.1">
        <property type="nucleotide sequence ID" value="XM_066759295.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991689"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="1">
        <location>
            <begin position="66"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="278" mass="30824" checksum="6850012AFFC56397" modified="2025-10-08" version="1">MTLLSGTVQPPLLSLLSSTSSPALSPLFIAVTDSSSPNSVITTINDNQQVEKAGSRITIPKNPTQGSIADQVIHIQSPDLRSTYIQAGCSQTAFRRSLKGKEQDDMMVPLGVELPWIGMQVKKLSRRELSFEVGVVDSRGREGVIRCSSYKTDPSIHSHRSPPLVHLPLSVLSSESSSELTPWRHIELNLSSLIPLFQNLARKYEEEEEKGTGSRKKRKTEIQLPNGGFRSVSYVRIYANCRIGRIWFSSEGEKTLESMGRGVRDEWALYASQNIPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPV9</accession>
    <name>A0ABR3BPV9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">I308_104109</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">IND107</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613036.1">
        <property type="nucleotide sequence ID" value="XM_066758588.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990965"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="24">
        <location>
            <begin position="393"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="135"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="23">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAL0247075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="745" mass="82294" checksum="20FB55702CFB6AA3" modified="2025-10-08" version="1">MFYPHHQSQQSTTTSASKHHDSQDVRLPGTSSWSRHPSHPSFTPSLPMPSPSGYPPLGSGYPPPGGHHHPNVNVHSGIHGPHPSFGSGMGGNGGMGHGPGFGMGMFQNGVQTSPPRGEPVPMTSHWQTQMVRAEASRSASSPHHRARAAAISSRATNKPSAVPIVDPNTRPSSSYSTNGLHRKNASSVFNAEPTGTPPLSDPSLTPAQNPAEPATPAPGASLTESKEEEKPNEPWTGLDLGGIRLKRLSTALFSFTHVTSLYINHNALTSIPSAISSLRQLTLLDATGNELSTIPPEIGVLCKLKDLLLFDNNLTTLPFELGTLYQLDCLGIDGNPMNADYRKKLVEDGTKGLITYLRDHAPPPPPPPERQWIDLETDVDTPTSGKQESFSVLTYNILCASFAPATTYSYTPSWALDWDYRKRLLLEEIVTASADVVCLQEIDCKQYADYFYPMLKKEGYEGQHYPRSRAKTMSADEQKLVDGCATFWKEEKFRLVETQVIEFNQLALQKTDMRTEDMFNRVMSRDNIAVVAALEFRTSGGRLLVANSHIYWDHRYRDVKLVQIGMLMEELEKIVEQFSKYPVKLDTDPEYNNGKPPKYERSEKGRDIPLIMCVDLNSFSGSAVYDYLSSGSIPGDHEDFMSHLYGRYTASGLKHHLGLRSACAGIGEMKMTNFTPTFAAAIDYVFYTPRTMKVTSVLGDVDKAYLDKTVGFPNAHFPSDHIPVFTQFRIKGHPDPLPLNGDSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ06</accession>
    <name>A0ABR3BQ06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase I-specific transcription initiation factor RRN6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612063.1">
        <property type="nucleotide sequence ID" value="XM_066760117.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992521"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048536">
        <property type="entry name" value="Rrn6_K-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20639">
        <property type="entry name" value="Rrn6_K-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 beta-propeller" evidence="2">
        <location>
            <begin position="181"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 K-rich C-terminal" evidence="3">
        <location>
            <begin position="1006"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0243696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1179" mass="132363" checksum="0E1AE3722DC68B69" modified="2025-10-08" version="1">MSFPPSVNHLVLPRTKGRNNNIHNNQTEYSEDNQFQDNIDEQERDQVDDAVGVGGPTVEFGRQGGVCLQRKRGAWGWLWSIEDRQDLKWRAGKEAIHFFPATRTPEIEPDPELSLKEVINSSVQYAEDLCLPYERDGLRDVITGILMEEHAVGPSGTSKQPAGPLPKTEEGSFDETQIYQGSIVAIIQNSRGKSARMFVAFPTGEVGHHLNIAPFLATSATRVDKRNRFRFTPTVKPIDRFPTSILQICSSPMVSSSRIDHDATALLVRTRTTTHLLNLHPSSTPFSAYVTSTRISELSFSDTECRRHVDVVLDPATWSRALVVDEGGGVWMWWEEKEIRRGRLEKVMNLRKIRDKITDERDQFFRISFGTQPGTALILSSREATLIDIDSLDHPTTSLITLSGFTRRFTFLEKTALERGSRYTTICTTHEVFWLDESGKGSPALGFKHEYGVTNMEAIVFPGQGKDQMTTLLYSPSQPFITALTTPKSVPIRFLTPPYVLSLPLQQDITVKELSYLSLNSSRHPPSLMILDQDGGLWCMSLISSRDAHFAAVASAGGKEGQKQRQEIVPISAQWDDEVSSLAAKERDREELGVGEGWREKAQVAYQEIDLRWVWLTINQQDIKIFSSEPSVASLSDIGEREEEGESAELMTRNDWLTDDERESGEQAVDKEKEGEDAGNEEERDAEARLEETDDEERDWEEGGEIESHEAATNAADIATEEAKKDDDEGDEGDWEDEEGEGEEGLEGKQLQGQETESWFKPEEFAQYLRELEAPMDGLVTGSELALDMCFPSTSFLGENVRKWDDAEEDAVLQTLIIHPYAIRSTLEGMDELVLSKLVPISHTLHSKFPSFTESRPPLPLPHQKPSQLYGSLLESFPPFSLRDNLSAAQLTLNLHLSAWIVSPSDYLPLTRAAHDRLIDAAVEEEQRGDEVELFVQATSQLSLNDRTPPVIEFNVVKPKLAPLKSGYKGLDIVESESEWEDIHENDEKRKEEKRMERLQTHIARTLNDDWKLGQDPAYWTWTPMGLEGTQWNPDHAIDPTQGDAQQPMGGIAGTQKESDRRIRPLPSSRSHPSLSLSQLRSRVQPPSPPHTSHFHSFSHLIPPSLSTSRSVPSIPSLAQGPRSSPPPTMSQMGIVTSSQPERESQDQEMGWASTQVERGKFGGKLEKKKKNKKRLGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQB2</accession>
    <name>A0ABR3BQB2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104417</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613342.1">
        <property type="nucleotide sequence ID" value="XM_066758894.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991273"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="94"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="400" mass="44111" checksum="160BFEBE20AB7760" modified="2025-10-08" version="1">MPKAAAGPSTKASKPKATQNGAPKLYSNFLPLPILIPTPIPIPSSSSSKSKSKAVNETKHYLYCRAHKSKASSASTSSKAKNTEGGEELLPEGRTVFVVNLPVDVTDRELRTVFGRYGVVEDVRIGKRETGDVLEGVVRGMEVEQSDDEDEDEDEDDENEDEDEDEDESNDERPEATFKGDRLTKKQRRALRRRNLPTSIPQIEPLPRLCPRSTPYLPSGLSSAHIIFLDPISVSRLFSSTPVPVSLPKYGKGELSGLAYYDALYKSLRPSLSAIKSFADTSMARFDHLHSLLLSSRAKEQGAGALVDEDGFTVVVRSGKYGRAGARGDGFGKGGVGVATRGFEKKKQGKGGKGSQALPDFYKFQTLDRKRQDLAELRQKFEHDKARVEELKKSRRYKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQZ4</accession>
    <name>A0ABR3BQZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105289</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612393.1">
        <property type="nucleotide sequence ID" value="XM_066759746.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992145"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="20"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0244026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="495" mass="54330" checksum="DCA76FFC9636DAAD" modified="2025-10-08" version="1">MTEEEIAIERKVVRKVDAILLPIMLVSYGLQYYDKSVLGTAAVYGIIKDLHLQTTVNGVVSTTRYSTATAAFYYGYIVGVLPIAFLFTRLPLAKTTAFFVIIWGLVCILTVVCTSYQGFTVQRVVLGICESAVSPAFVAICALWWEPQEQAKRIGFFYSATGVFSMFSSLVNIGLGKTGGAHPWKSMYYFVGALTIFWGFVIFLILPDHPLRPGRWFTAEERVVLARRFARNQAGASQQPIKPYQVLEAVRDIKTWLYLLMAASIYICNGSVTAFGAKIITGLGYTSLQATALLVPGGAMTVITIAIFSYYADKYTNIRTLLLPISCIPVIVGAIVIWTAPWKPTAGPLIGYYLVASFGAPYVLLLTLASSNTAGATKKAVTTGFIFIGYNAGNIAAAYLVFAKEAHIKYRSTWISVIVGMVFASAASLVLRWLYVRENKKRDKEELAEKQSEETTRTDEEKAALEGSVDSLDGLASLVVADKSDKKIPGFRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR71</accession>
    <name>A0ABR3BR71_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103771</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613654.1">
        <property type="nucleotide sequence ID" value="XM_066758252.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990627"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028841">
        <property type="entry name" value="APC10_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="8">
        <location>
            <begin position="6"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="229" mass="25325" checksum="951831B498FD3258" modified="2025-10-08" version="1">MSSPAPNTPSPPSHTSGLPSLPSLLERPELSHLAQWSVSSHKYGFGVDNLRDGNDSTFWQSEGAQPHTIDLAFPRKVMISAIAVHMSHPRDDSYTPSKIGIRCGTGVHDLQEVRYLEFSKPDGWHLIPLRPMEHTTSGPEKEGPPIPCHFLRILIFANHLNGKDTHVRGLKVFGPPGPKENKQLTASPLHKMSQQATQEVGGGRKLLELGHDGLSGFTSTEFKMHEWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR92</accession>
    <name>A0ABR3BR92_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104423</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613348.1">
        <property type="nucleotide sequence ID" value="XM_066758900.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991279"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="496"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="537"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0247387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="689" mass="77360" checksum="DCD055AED7C20083" modified="2025-10-08" version="1">MFRLRPVPDSVPHRLAAIRPTRSLPASTFRSLSNNAGGKIVTLTSSALSQNFFAGHHRPSLKPHYQLNLVRTRTTFRFPSIPSEKFAGKHPYVSVSIRLVLSSVLGLVFLTGAILVHDASTYSERHVDRVPCNPLSLKPRVGGKKNLPIIEVNLDDEEDETKRAMKGKPRLVIIGGGWGAVSLIQSLPAHAYNVTLISPQTYFAFTPLLPSACVGTVEPRSLVEPLRKLVARVRGHYLMGAAVDLDMTERLVEVEVPKEDGQGTMRCYVPYDKLVIAVGSTTNNHGVKGLEHCYQLKTVPDAQAIRRKVMDNLELASLPTTTPEERKKLLSFVVCGGGPTGVEFAAELADMMAEDVLKYYPKILSSEVQVTVIQSRDHILNTYSEKISQYAEKRFARNDVRVIINARVQEVKDDRVILSVKDSNNKDAKPEVKELEAGFVLWSTGIAMQPFTKRLVELLPNQYHSKAVEIDGFLRVQGAPQGSVYALGDASTVQTNLMKDLYNLWDKFDINKDGNIDYEEWQEMVKYIKKKHPLAHRSLTKMRAVFEEFDRDHDEKLSLDEVAELFAKLSKKVTSYPATAQVASQQGKYLGAKFGKLAKQQETLSKNGIVDLDDESYYHPFEYQHLGSLAYIGNSAVFDYEGWSLAGGLLAMYAWRSIYWSEQTSMRTRMLLMLDWVKRGIFGRDLSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRN2</accession>
    <name>A0ABR3BRN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613525.1">
        <property type="nucleotide sequence ID" value="XM_066758123.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990492"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF452">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047364574" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="541" mass="59846" checksum="2A0EDD6202DB466A" modified="2025-10-08" version="1">MRLSTLALMATPALALPNYLRLSNGPSELASNLATHAISSTQAWLQDAVSNTRNSVQNGWKGIQDGLDQELKVENIDKDGIEYLALSHPAFPLHRLRVVKPELCDSSVKQLSGYLDISETRHLFFWFQESRQNPDEDPLVLWLNGGPGCSSTTGLLFELGGCNIRDKGENTTFNEYSWNSIANVLYLDQPIGVGYSYADEGEVNNSPAAAEDVYAFLVLFISKFREYSELDFHIAGESYAGTYIPNIASVVHKNNIALDLVPTPSIPKINLKSVMIGNGLTDPYAQFGSVPDWACNSTYAPYDDPSPECDSLRTRASRCQGLISGCYKTNSRFTCVPAALYCWSMFNELQDLGLNMYDVRKTCDKSPEKDGPLCYREMGWMETYLNKPDVKKELGAPESVTFQSCNMQINQNFLLHGDGMHYAGGLLPDLIEDDIRVLVYAGQADMLVNYIGCASVLDNLQTGYLASYLAAPVVNFTSPDGEVFGYTKSASKDDKGSGNVAFVAFHNAGHMVPHDDPEAALRMAGRWWKNEPLAVAKDEWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRU3</accession>
    <name>A0ABR3BRU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_103967</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613850.1">
        <property type="nucleotide sequence ID" value="XM_066758448.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990823"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="256"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="971"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0247889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1463" mass="162852" checksum="CE5C507DA0664FB3" modified="2025-10-08" version="1">MDTWAVVDQNEKHYVSSDVPRRIKHIQFQPFTPKDIVRISEVQVSIAELYQNNEDGSRTTALQGPLDARMGPNEKGKKCATCGEDTQKCVGHYGYIKLVLPVFHIGYFRPTINMLSCICKTCARVLLPETERASFLKRFRRPNLESLQRQSAAKAVLAACKKQNICTYCGAPNGIVKKSGPLRISHEPYRAAKMASMKDEWMATFKNAVAENQAVATHLGKAVDDLNPLKVLNLFERVTAEDCELLSLHPDVGRPEDYIWQYISVPPPCIRPSVASEAGNNEDDLTAKLAEIVNYNNTLALMMDLGRGIEMISSNWEVLGQAVALYINSQAPGMQTIGSKPIRGFVQRLKGKQGRFRGNLSGKRVDFSGRTVIGPDPNLRIDEVAVPEKVAVKLSYPERVTDYNLQLMRQAIINGSKLHPGANVLERKHENGSTVRISLNVMKDLEARKRYARELQIGDVVHRHVRDGDIVLFNRQPSLHKLSIMCHRVRVRPWRTFRLNECVCNPYNADFDGDEMNLHVPQTEEARTEALELMSVKKNLVTPRNGEPIIAAIQDFITAAYLLSRRDRFYDRQQFTQIASYLGDANLKIEMPPPTIWKPVRLWTGKQIFNLLMRPNKESKVLVNLEAKCRTLVDPAKEDRFPPDMSPNDGYLVIQNSEIMCGVFDKNTVGDGKKNSVFGVILRDYGPEEAAQAMNRLAKIAARWLANIGFSLGINDVIPGPILHASKDARVEKAYGECDVFIDLAKRGKLENAPGCDQEATLESKISKTLSDVREAVGKICMQELSRHNAPLIMATCGSKGSVINVAQMVACVGQQIIGGSRVRNGFQDRSLPHFRKKSKNPPSKGFVRNSFFSGLTPPEFLFHAMSGREGLVDTAVKTAETGYMARRLMKALEDLCTHYDLSVRNSVGGIVQFQYGDDMLDPACLEGDATPVEYVRSWTHACRTAGNQGRALFPYEVRRIAARIYPESFILPSPPPSPPKTKGRRRKEPTPPPPVVAPTLPKEWEGCHHKFRENTYKFVVDKIVKQMVDQRLARGLPDADDEEMAEEYEALLYSDDPAVQRVLENANKVTEAQVNSFLENCRIRYLRAKIEPGSTVGAVGAQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINAAKVISTPIIAAELAIPESETAARIVKGRIEKTVLGDIAAVIEESWTNANAYIEVHIDMDAVRRLQLEISLESIKWALVRANKLKIPEGSIHISQKTSRIRIWIDESDKDKGVGIYERLKFLKRAIPSVQVKGLPAIERGVVTKDEKDEKIHRLLVTGYGLSEVMGTEGVDGLKTKTNHVMETQQVLGIEAARSTIYNEIQTTMKSHGMSIDPRHVMLLGDVMTYKGEVLGITRFGVQKMKDSVLMLASFEKTTDHLFDASLYSKKDEIQGVSECIIMGTPAPGCGTSLASIVTPAPPLPAKKPLLFETAYKAGQHRMSKIAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRV7</accession>
    <name>A0ABR3BRV7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613867.1">
        <property type="nucleotide sequence ID" value="XM_066758465.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990840"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="285" mass="31251" checksum="EAE99ECB7EEA1097" modified="2025-10-08" version="1">MDMSGMDHMSSTSSNMSMSMKMYFHGTIGGDMLWFASWMPSSAGATVGVCIGLFILAIFERYLIAFRRACDAAWRKGQVGYVRPSSNGPLTSSSAKSTSLSPPVLLNRRSSNKKEDVLFTPSAYAFESNHDGAVEPVAPYSPSVLAVRDSQEGSSAPSYTHSQQGQTQAQGQSEKGIACNPCAEERVAEIERYKEKAVETGVTHSHLPKAVRRSLDPGREGRWSRPFRLAVDIPRGLLQALQTFIHYLLMLVVMTFNIWWMISVVIGCGVGEMLFGRFGSSHVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRV8</accession>
    <name>A0ABR3BRV8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103843</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613726.1">
        <property type="nucleotide sequence ID" value="XM_066758324.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990699"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="448"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0247765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="870" mass="95208" checksum="149D3B3E9BC31CC2" modified="2025-10-08" version="1">MASSDEINNPLSRQNSTNSLNNPAGTPSSRKDPHSLNDSEVIAASGVRHPSANHRPNASISGSSAHLRPRPASRNASPTSTLSRRKSSPNLSVPSSGKDLSGGDGSRASGAERIIKGTSKWLRDKMGGSDEKDDHWLVLDLPSPSMLSDAGSMAIPIYDTRGYPSREGSLDRPRIAVDTGARQPGPVLTSAPEINVYLSQSTKNKPSPLGYTHNASLTPLAAQFPARSASPLSTSAPSLADFYPPDTAIFGNRTLGSGPRPALSVFGSSESSVMTFRSMSSLRSGFGTDSDSATRLRLNSDATSDDGLIDKEARLKKHVAKVVYDMNDILPKLRLVNELEGNEEKLGLYDLLPFHIDPSQWEGTNSEDDDELHRPEPQDIPDTQYFSSRGLANLGCLAILGLIIVMLFAGLPIFEYYNTLPANTLGAFNIGGINSTGQVPDVANIFQLIDPHTPPEAYTHKSLDTGEEWDLVFSDEFNEDGRTFYNGDDPFWEAVDLHYWQTNNLEWYDPGRLTTRNGKLVITLDEIYSHGMNFEGGMMSSWNRFCFTGGYMEVSVSLPGANDIPGLWPAIWTMGNLGRAGYGGSLDGTWPYTYDSCDVGTLPNQTLNGKAFLLTGEQHLINVIRCTCPDDDTHPGPKHSDGSFVGRSAPEIDIFEATIDMSIAKGQVSQSGQWAPFNPNYYFINSSSEYYEIYDNDVTQINSYMGSVYQQATSGLSLTNQDCYTDESGCFAVYGMEYAPGGDGYITWVNDNKKAWTIHGAAMGPNEEAGVNQRPVTEEPMYMILNLGISENFGAVHFAGLEKLWPVQMEVDYVRVYQDPKKKNVGCDPVDRPTASYIARFPEAYSNSNITTFDQVPNKKRPKNRLVDQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRW2</accession>
    <name>A0ABR3BRW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613020.1">
        <property type="nucleotide sequence ID" value="XM_066758572.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990949"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF33">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="722" mass="78871" checksum="114EB24DD3515B2C" modified="2025-10-08" version="1">MHPSPAKRPRRTSSPEPDTPMSQGPLRHPSPSRTLPPIQGAAPPPSHGGPSTWSSAWRGASRPSQGAEGSESPKMEEDEPAPSGTTGGGPSGAAPASSSSVVFTRDVNTRAPRSMMACVRCRRQKMKCDGPSKVPCRGCRQAGQQCIFEPRSRPKSISVIPSRPYYPGRPGSPASFYPSGPQPAPPITSRPMNQEYAFRPTTREMPPPPATSAISSFYPGQPPRRTPPPQSVSSAGPSGVYFQHPPPPPPVVHPPPFTVPVQRPPPSPSSSDARLRALERTIDSTLRPLAWVPSALSSLQQSVAELRAQVAPRRVLTVADTTWEHYRTRAWPLTPWLIGLRDGVGLPGMVVDFLGRRAEEVEKMAAGQGMGSTMGLEGEARREVGRLIGEGKEWGKEEMRALTVLATWTNDTIYAGLAVAHGRMMGLDRQRRTHDDWREWIYIVIMDNMCHIPDFLKPVTDEGLSAVWRDRLAELPSAEPAIRDRDAKLLAWLEYSELLADVFRFRMPPLSRDPEYQTPLEAREKRLFDPWREFGRQWEGWANAFGARADPILSLHYTYAVLFTVSPVYFADAAAWEELAASPDGQPLLERGREAAIGVIQSICSAEVGRTLPYSFALYRPLLGLAVFHLISLAASLPTISTVSSSMNVITMTLRQAYDVLNAQVPDREALPGPSAGIPGVGTGVVLPGGLLAEVVESGRVDVGKRWIGMDVGREAWRRIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRX5</accession>
    <name>A0ABR3BRX5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aspartate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104464</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613389.1">
        <property type="nucleotide sequence ID" value="XM_066758941.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991320"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="237"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="742"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0247428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="884" mass="100581" checksum="C668668FB54FD6A5" modified="2025-10-08" version="1">MSSTDTTTNPIIKLGRVLKPSNSNSEDRPGLPRSSTHEREARHAVEKQREQARQEAKKQKIEHENHEIQRRRQIADEKAQLQEDPETRASYGDLNELEEITPFEEVIDMPAGTKVNIRGRIHQQRDLSSHLNFILLRQRGFVIQGVLSEHASEHMIKWVQHLPGEAIVQVSGTLREPPKPITAAVDTPLELDIERLYLVETSHDIPFNLAHGDRPPQSTRLRNRTLDLRHPTAQAIFKIRAKVLKVFRDTLDDLGFLEINTPKLQPSATESGAEVFRVNYFGRKAFLAQSPQLMKQMAISADFRRVYEIGPVFRAENSNTHRHLTEYTGLDIEMAIQQEYYEVFRVLDIVLRNIFKAIKGMKLELDRVREFFPSDDFQLPEETPIIPFHEAVQMLRDDGRDVEEEDFSTPDEIRLGELIKEKLGTDYYVIDKFPVSARPFYTANDGKVTNSFDMFIRGQEICTGGQRINDPKKLRESMEESGINEDEMAEYLQAFDWGMPPHGGAGLGVERIVTFFLNLPDVRLSTLWHRDPHSLPTKPPGLPHGDADTLKKIDPNNPPPIENLIANYGDATNTSWLDDRFDIWRDRETGAAIGYSTKNSKFCMITGDPLCDDGQKKQVTRRFLNFVRGEVKMKPVWLLVSEMMMEILVYEFGWRALSCTQEQRSNSDKADPSVVQSSAQKKGVFNVREVEPTEGIQKKCDARIEEWSAGRDGKGKQIHLTDVAPWKDTEHRRYFIAQSDHNANEKGENNEPKSKKDEQTIDTLVVLARLAPSKGYQLKWALDFPGSPHDAIESTVQAALSAVPGEPVTFGTAVSESLVTKHGIGGLRATFMERTYRSIVKSLSLDKKAGFREKFGVSGDLTYICYPKGGVKLYELKDIVKFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRY2</accession>
    <name>A0ABR3BRY2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613897.1">
        <property type="nucleotide sequence ID" value="XM_066757513.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989867"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0249710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="678" mass="78035" checksum="A4DF99CF494253A7" modified="2025-10-08" version="1">MSGDTYPSSPSSTPLSPTAYKIALHRISPAERLIYYLYLPFLLFILILLAILATLPYLFFKRARPRLLPGSRPDPKYPKSGYEWYGPEKDYPPGLALAPLGQGPGAKWRVWEMYGYFREFWHMTTRQGLQVGGVGSGVVMLVFQVEMMWHDYSASNITTYQDSSSGGEGDSGNGLRGDSRCAYATGTGIANWGSRFEPLAWYGCYHGFICIICICLIGDELLNVRFGCFAPQWYRGGIGYTIMFLAAATLSTSPNWGVTSLIQLRYVVITTIFLFGTYNLVRTFTCALGMATSGFRHTDYRVGRKPLRPWTESEWIDPYYRQNFIPHKYDRYFLTERWQFAVGDWNFPLERRPREDVERQMDEFDGLDSFMMDGRIQKVWQRSPEEIRRMHGKIGRTVIHGGPKKMPPHMTNDLKQRERIHIGLIDPRNPPTEEEEEKMIKALNEDKGYFGIANWKPRTKSFGWWWFDMRRVWAIFCGLALMGVRIGLCVFDLDYSSIASYRSQYDQAKTAWEATDNDGPDASKCQYYQGSNVPIFVITGEGSYSGGIWHTFLIGMCAAIIFVSISNNMWWGMHWPFPPMTLIGPRMSSMSIGVTLGFVAFATLQQGFFFSNDSLILVVRIICYASVIGFIMFLYPNEPLRTSYTRDPFWPWLSRVAFRFMDRKKWHYSMKDFDDAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRZ2</accession>
    <name>A0ABR3BRZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CLASP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613895.1">
        <property type="nucleotide sequence ID" value="XM_066757511.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989865"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF60">
        <property type="entry name" value="CLASP N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLASP N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="591"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="670"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="864"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="901"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="947"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="997"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1082"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1144"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1335"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="608"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="700"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="726"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="812"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="902"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="923"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1047"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1082"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1169"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1183"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1233"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1250"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1339"/>
            <end position="1349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0249708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1359" mass="146337" checksum="24791185063B9D64" modified="2025-10-08" version="1">MPTITGDTKIPVPTIRHFADELDSLAYALEPEEREGTWEKFEKAIIRFTAVTRGGGYQFTESYVEGVGRGGVGSKIVRCMLSDRGRLSGVAIELVQTFAPQLGLHFKPLVNLYLEPLIDLLGRPNKVFLKRAEKCLAVIISNCQIPTILTSLHRGLDDNAASCRKGCAMGVERAVKEWPVELWTEKWLVILEESLKKMATNKDPDVRKAGKNVWALFIDAWPERVDEFSAPLTPTIRRYLDISGAGGLSKSKPTCPAPARKVLPPLTSSTISDYNKTLQSRVDLLSGPRAAHASSSASVTEADPSGKRSSHTEPTISHEPHCISKAYHEYSRQERSRALETVPLVSMHAHAPSGAFLHDVPPSPSNPSAFFSPPVRPEHHTQQAKPKALSKPVRPTMPTSYSVPALHANPYSYVSSSTSGRTDEPVRPRRLGQAQRIKVTLPVEGEEGDQEREQREHGRGRDKEGPLRGAVRPITAGIGGLGKKAGLGRAERRVVTAPLPMVGGPLTTGAFEGGAVRLRKKEHHIAVTGEEQAECGSTTHAFLPPQEGSAPEAGPRIHHLQSETQQEQQGFFSPVVAHILKKNVDSPLLPVLMGSHSRSPSPSSTPSLENQLPPTTSTPSIAHPSTSVLDSASLLEQKNVSESEAQEGEEKNEEEEMELIKIYLKEVYPLTPPSVKPSSKKKEEVELAKRVELPGSPTKIVEEDGQKEEREDKECPERKEKGQEGAPASISTSPTASVPAPASNTTTSAPVPPPPPASIINAPHSRKPPIPTVASARPLNPRPRVISGPSLSTKPMNKPPTKPIVRKAFRPTSSTSSTSAPATAAASASGSGGSHLTAATMASRAKVVAMNPSKPVIVTSSMNVNASNTGVGNEAASSTAGRTAKAQYNNTAFSSTKSLANVKEKGKERTKQEPVRRAEAKKAATAVPALSRQASISSIAAASTLANGQANAMPGRKPPVPSHVTLPPAKKERKKLKVPLPSFRPARVRPAVFAPLSTSGTEVKGQRVRGKEMRPGMIRLPDSPPPEGNKSNTKGTGLGVKEASGVVKREEVPRSADPHEIALSEAPQESLSLISAETALKLEENKEKEREGDKSPTFSSARSARLRTLEEMPQSPIKPKKGRPANPLLTTGVEAVYPLLESDAGFEDHELRDEDEIKVDNRKVAGNENEGEEEIAIEEADERDQKDERKQDHMGEHVMQENEINISRARPPNAYFPIFEPSATSGVSPRPSSPSLPTQSHTSSPASTFSTLSTATPHLPTHTSPTSRYTLATRNEASAPYNSAIPLLSKLESEVLIVESGNVQSFGMSVEDEGILVTAERRALAVKDVNKVQTNSVKQGDKRKGERLGTSEMGFEVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS35</accession>
    <name>A0ABR3BS35_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612813.1">
        <property type="nucleotide sequence ID" value="XM_066759326.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991720"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="91" mass="9898" checksum="F2134066BDCA3C53" modified="2025-10-08" version="1">MTRNTDNLSQGTELTSFNGSSRNVPTESTPEDGYNAWKEASDDLNVTRSIIASAENGGMSESAVDSLRERASVLQQTVDHYETKIPSSKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS83</accession>
    <name>A0ABR3BS83_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613999.1">
        <property type="nucleotide sequence ID" value="XM_066757615.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989970"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036580">
        <property type="entry name" value="Cyclin_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="38"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="183"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="323" mass="36987" checksum="B61EAA8C4D9EE820" modified="2025-10-08" version="1">MSHAPHPLATLEQIVSTPSAADGIPSDVENDLRIAGCMLIQEAGVMLKLPQSTMGTAQVLLHRFYYVSSMCSFGINDISISALFLASKLCESPVRLRDLINTYLYLLARIQHLLDLPADQSFHSGLSSHSDGRKEDKVWEGFKFSVPGFHDEIFWDWKDVITASEMQILKRLGFNMQVDLPYNHMINYLKILDLVFEDDVAQMCWSILNDMLLTPLYAIHPPHTIACISILLTTRLLRIPLPPKWYLLFDVSYDEIWSGCGVVMRLWNNWGLDRPRGDTKISIRTPNEEEEGKKGKESRWRRAWVLAQSRKAVRRWVEGLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSX1</accession>
    <name>A0ABR3BSX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">IPO4/5-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614071.1">
        <property type="nucleotide sequence ID" value="XM_066757687.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990043"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IPO4/5-like TPR repeats" evidence="8">
        <location>
            <begin position="146"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0249884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="910" mass="100511" checksum="DC3236745FA21148" modified="2025-10-08" version="1">MSTEHLLGDIGAVLTAFIASEDHPRREAEAHLQRLAVEQPAEVLLVLAQVGALGVGGFQLDHRLLALILLKRMAFKPLDGLFLNPQSQHPAAPFDVIRETTRGRIETVICAGIKDEMDVRMRKGLGACAANWAHECAIRHRPLLPLPPVLLELTASPHPFHRFTPFQLLDLAPTLLVDSVRDPIPAEQLAQMLQVGLNDPSVDVRVEAMKAVRSVLIEGVTGSERSEIGANLVLHSFETLRNLPPPLASHALIPLVDLASTHPGLFMTSLNPILSSLLPLLAPPAQETNLPPFQFSPYPPHNMTFEEWEDISNPATEIILSLVELRPTHMSEWENGKSVKEMIGLLLARQVVTFGNDSQDWLETKDLDEEAEEYPVLAEESLSRLSMALGGDLVLPTLSLQVQALLQQEDWRCRFAAIAGISSVAEGCLDELQAGLREVLAMLSSAAKDPHPRVRYEFLQCLGQMSADLEGALQENFADDVLQISLALLDDPIMRVRSHSAASLTNFFQEASPRHFEKYLEPIVRGLLNLYQSQVLYAQDQALATLATVATAAEKMFTPFYRNIMDLCFMILSNPAITDVAQRKLQGRAMECGTLLGIAVGKNMFGTDAVKLSQLMITIQNQIVDADDPRSGYLMDAWSNVCQSLGASFEPFLQYVVPNLLETASYKPSDSSDGTGEEQEDDTGGAHTYEIDQKIMAFESLTTYAFQMRGKFAPWLAPCMQLSLNELSCSFSEDVREAAAFLVPGLLQVAKDSQVWADAPYNFTQVFQQLVNVIVKTNDIGYTALLYKSFTDSLHVISAPFPAELTTQLLKSGHAVLHTIAQTRADREAQEPYMDESDKEIYFEEQNEEEACLTHFRKALEMVIKVGDSNAGTEQGALANGLREELQGAIDMVREVRKRGMKGDGEKRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT72</accession>
    <name>A0ABR3BT72_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614342.1">
        <property type="nucleotide sequence ID" value="XM_066757958.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990319"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47272" checksum="3BB3BDE68FFA88F8" modified="2025-10-08" version="1">MTHRSRSGGPQKKHGGKKQQTHTRKLHHPPAPQPETSPLPVPDNLPLPPAEGPFNPPDSELLALIRRALHSTLSSDEFQPTIQKIKGLLYDKKWLEVFCGPEGLLESYAGRWVPSRAACFRELMGQLVGEVFDGEEGVEKDLNKLSLGDDESDEDQEETEEKGQAEDVKGQEESEQVDKDASGDVSPTQKPTHHILSLGGGAGSEFLAISALIRSTLLSRPRTHPSWTWTGIDIGNWHNVLKKLENTIRMDWEITEDMLEMEYVKGDLMASVEPIARKEGEKKDGDGEIMEGIDMSPIDLKGLLTRKSPSLITLFFTLAELLTQSRPSTLSLLATLTAQCKPGTLFLIADSASDISEFSIGSEGRKWPAWMVVDAVLTGKERGWEKVREEESRWFRFEEGVGAGWPCKLENTRYWYRLYRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT94</accession>
    <name>A0ABR3BT94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA repair protein RAD16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_103481</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614360.1">
        <property type="nucleotide sequence ID" value="XM_066757976.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990337"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="450"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="790"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="873"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0250173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1044" mass="117124" checksum="6E04515A0DFB84AA" modified="2025-10-08" version="1">MPALRTTRKSAQNQPEMAVSDPIDDMVVDGTSPVKTRRQSVVEVSIATRRTRSSTSKTVSVAPNSVDPDETEDEDWANDDVKMENGDSDLELIEDQKPQIGGINGKGKGKAKEHAQPFNIGKYSRVAKASVANLKDDTRISSRSSRAPRRSKSQASVRVEELNDDSTESEYVDDGGEYAVDSEDEARQLKQAIQASTSKAASAKGKKTNRAALNAAVARVAGQRSGQSSTATGTTNATPLSDDDPVPSDSEFEEAEEEVSDLSDLSTSDSEVDVPLSRGKNSVRGGRGGAQGGKSARTTSTKGKTAAKRKTKKFQGKGRKLGGSDSEEEQFDEAEALDDEDESLSELSDPNMSWLEKRQMQKRKERRHAARAAAPRKKKERELAKKLGRKLTNGEKNLIALCMHRPELENVWGDLQANIEPVKPITMEAHPSLKLTLLPFQKESLYWMKKQEEGPWKGGMLADEMGMGKTIQTIALLLSEPRRKPSLVVAPVVALMQWKNEIETHAEGFTVCLWHGQGRMKAAELKKFDVVLVSYGTLEASFRRQQRGFKRGDKFIKEKSPMHEFEWYRVVLDEAHNIKERSTNAAKAAFALKATYKWCLSGTPLQNRVGELYSLVRFLGADPFSHYFCKKCPCKRLHWQFSDKRHCDECGHKPMDHVCFWNTEILTPIAKYGIEEGGPGHTAFKKLKVLLDRMMLRRTKLERADDLGLPPRTIVVRRDYFSPQEKELYMSLFTNAKRQFATYVGQGTVLNNYSNIFSLITRMRQMACHPDLVLRSKNSTLTDVQEGTVCRICNDTAEDAIMSQCKHVFDRECIKQYLEVKQMRGHKPECPVCHIEISIDLEAEALDLEENTKKARQGILSRLDLNNWRSSSKLEALVEELEKLRHKDCTIKSLVFSQFVSFLDLIAFRLQRAGFNICRLEGGMTPQQRDATIQHFMKHTGVTVFLISLKAGGVALNLTEASMVFMMDSWWNPSVEYQAMDRIHRLGQKRPVKVVKLVIEDSIEDQIVQLQAKKLAMTEAALSSDSDSALGKLTVEDLGFLFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTE0</accession>
    <name>A0ABR3BTE0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614098.1">
        <property type="nucleotide sequence ID" value="XM_066757714.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990070"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0249911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="108" mass="11773" checksum="E479A68FD2565802" modified="2025-10-08" version="1">MATATPALDRLSPAQAQPAETCFVVRFKSIGSAPIMKNNVFKATAGHKFQAVIMFLRQQLGMKKEDSLFTYINAAFAPAPDDTVGNLYKSFGTEGHLIVNYSNTQAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTZ4</accession>
    <name>A0ABR3BTZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102583</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614597.1">
        <property type="nucleotide sequence ID" value="XM_066757128.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989440"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="452" mass="46658" checksum="56735378C9663454" modified="2025-10-08" version="1">MPFPPSMPVGQQPLSIPPSSDVAQQAFGFNSAGNSFPRQNSFGMQSQGAPSRWDPASQSAQGGLAQANGNAGMVSGLSALMRSRGTDVELNSSPPGGAHSSLSSNPHAGFHPSSYGPNIGFTAFALGSSAQGAGSYLGTSNLGMSISPPNWGSLGSGSFVGSMGAFGTSLNREREGRERELEARYVKDFSCCGKRLNGLHELLEHYEEEHANMAPNVRMAALNAAQGINNSPRNVGNPFSAIPPTAASLIPQQPQTPQVGAASDAPQPPGMMDIEMEESAPYSQPISMAQIQQQPPQFGVRTPGLNGPTSGTNPWAAAFRPQLLATPPQCVPPSLLSYTPPTSSIPGGSSIPSAAPSPASLTPEQHAAKAERKARKRAERAAKDEGSASETEGAAVAGEKRFPCPIEGCGKVYKQANGLKYHLTRSINSGHGTIPPGGLAALLGEKGGEVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU27</accession>
    <name>A0ABR3BU27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613488.1">
        <property type="nucleotide sequence ID" value="XM_066758086.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990451"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24268" checksum="3FAC081E3BA8BE5B" modified="2025-10-08" version="1">MSSSPNNRAVRRKLVIVGDGAAGKTSLLNVFAVGHFPESYEPTVFDNYVTEIELDGKPVQLALWDTAGQEEYERLRPLSYSKAHVILIAFAVDTPDSLENVTQKWIEEVRSICGKAIPVILVACKTDLRDKAIANGTFSPERFTDRATGQRIADSIGAKGYFETSALQNKNVDAVFEAATRAAVLVRDAGHGGVGASNGSFDAGGRKDWGREKEEKKFGCCVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUJ3</accession>
    <name>A0ABR3BUJ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614798.1">
        <property type="nucleotide sequence ID" value="XM_066757329.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989650"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="72" mass="7707" checksum="8C4C5DF52BB47DAC" modified="2025-10-08" version="1">MSATQDEAVLRNARETIDSLYDLSQLLQTGLDKSTLSICVGMIEQGANPDTLAAVIKELRAENEALNSQGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUJ6</accession>
    <name>A0ABR3BUJ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102792</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614796.1">
        <property type="nucleotide sequence ID" value="XM_066757327.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989648"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="197" mass="21429" checksum="631063B9F887FE55" modified="2025-10-08" version="1">MSLIRLDYTVSQSKSSSIPNPPGYLAPFTTKQSASASSKHVQANDEALAKQARKSTELRMKRAWDLALSPAKSLPMQAVMLYFSGSGIQIFSLGMIFMLLTQPISAVLNIFQAFEPFRPTPSAMPRKGVKVAAEESTYAPLIGPMVIYVACQGLVLALGLYKCSSMGILPTGSGDWLHFETRSNPPEWSAIRSRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUS7</accession>
    <name>A0ABR3BUS7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614394.1">
        <property type="nucleotide sequence ID" value="XM_066758010.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990372"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08041">
        <property type="entry name" value="OBF_kDNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050326">
        <property type="entry name" value="NAD_dep_DNA_ligaseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810:SF1">
        <property type="entry name" value="DNA LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="6">
        <location>
            <begin position="231"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="554" mass="62258" checksum="A15098CE6832312E" modified="2025-10-08" version="1">MKKQNIIAGYPELRELLEYVYHPDHRTYMTFSSLKSFIDNPPKSFKPIDIPSATASKLSLIELFDQLSQKVVTGHEAKRTVVTFLMTHGVTGDAELLETFGRLLDRNLVAGFGAKTLVDVPWVEGGTKLSKTVPPPLPPYISPSSQSSQVASSPGPISRFSGGIAPILANFKPLDQFQVALGKSLEPPFSSLFKSEPIWYASRKLDGVRCLALIDVLVPSSSSKPLEFVHAHFVSRSGKPFHSLSKLSEQLRLLVRDHPDNPLREWLNNDPEIIEMREAGDVKRLVLDGEICLMRPKTEEELKTIQPRDDGSAADHMWMASDPSTEDFPSTVSAIRKSETIQHLSYFVFDVLSWAEVHAKQGIPLPGLGKKFSERIVDVERLRNWLDESIALGGIDEKERITRNLVQCKVEKPEDVEEMVKRAANEGWEGLILRADQPYKGNRSSDVRKFKKWQDAEYVVKSADTSTMRLAINGVFDEYEALANIWIEHKGHPVSVGSGFSAEERLRYAEKPEEIVGKTITVEYFSESDAIGREGTKSLRFPRVKTIWGEERDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV04</accession>
    <name>A0ABR3BV04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614469.1">
        <property type="nucleotide sequence ID" value="XM_066757000.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989312"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="479" mass="51543" checksum="3C4592D29A003084" modified="2025-10-08" version="1">MFSQWTRRVNESRLTQRKLTLLGRAIALVAGELLFNAVCWIAAGICFGKTDGILGLALLAWTIGLRHGLDADHISAIDNATRQLVSQGQLPITCGLFFSLGHSTIVIVVNVAIAVSVDIYDKLDRVGSIGGIVGASVSASFLFLIACLNIYFLIGAIKQRRSMKRRQALGLPPDEDEGDPSKIYGGGCMVRVVGPILRAVDRPWKMYPVGVLFGFGFDTASSIALLAISAIAQRGPNGDSISHGKIVILPFLFTAGMSLVDSLDSILMLYAYATPDSTSPEGKLALLQHPDYKDFHVEETVATTLTAEGDQTEGHPIEQIDFPQGEIERLETEDNLKAKTGNEISMEEERVGGPSRVDNIGGARNERVMKAKANTMSSLSIILTLLSILVALSISLIEIMGLIGDNCTQCQDAANDPDGGGLAGSWWRAWARANDQSGYIGAAIVGCFAAILFGWYGAKWGMKKWKARKDAKAAIVLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV16</accession>
    <name>A0ABR3BV16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">High-temperature-induced dauer-formation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614961.1">
        <property type="nucleotide sequence ID" value="XM_066757492.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989846"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="783"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="831"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1005" mass="107892" checksum="63972DE2040C8265" modified="2025-10-08" version="1">MFKLPSLPQAIGLPFLSATEDAQLKFKTGPNGVKRLSGAEVIPRTDVAYWAQWYTLFASAHDVYSLLGAHDIRHALHTNPANVATLVHHLSHHLFTLVPSPLFPHPPTATAQDLTKEALNCLRVLGRVLSVVYEAEGEGDGESFAAQYLWNRQKAPPVSPAPPADHFTIEDSDEDGDNEQNDGPELDTGARAFRATIESSSSPSAPISDPLTQPGSGERRDSGEDEYLPSLAERLFSCTIDLLFCAGFTLPQTVSEDQNDKINYVIWEKGVGSTIKIGSSPDLDRNKTEVLRFLLILLSSPLYMPPTSLPTTPNPPLFTLTHTLERRLVLSLLCSFLNTSLTRDPADPTGPGGSGGGLAGIVGGLGKLGSLSGLGLRAGEERRTLVRLCMSALLVALDYKMEGAPGLETGSGGAVMGEGKEENAFRYFLSKLHRKEDFTFILDGILAILAEYHASLTNGYLPGGVGVGVGKKDIGCLLETYILLWRLVDLNKRFKAHLLEQSGKTVDLVVYILVTCLELKDDPAQNGLLRLLSYLLQTLSANEPFGKSLNQTIRTAIPARWGVSGSAVDFMIVSIYSIATTPGLNPLFPALTISIANISPYITHIGVQASARLLGLFKAFSAPNFLLGDEGHPRLVYYLLETFNSVLYHQLNANPNLVYAILRSHNDFQTLATFTLMSGLRDIKRRKFLRAAAEKNGRASSGITNSYHTNHTNLTTRPGNGNGGGGNGNGITSDAEMIAEKAALLGVDPEEEDSVHLADVQGQGQGQGHASTPGEGEVPSLSTYPPAVTTLTPAPPTTATATATATADYSPNPPPPSRSISEKARGKMRATESTTSLTTINTNQEGAGVGGGEEEEDDEEEELMKIAAAGVGPNGYVPTQEWVSSWQKGLPLDPVLVAISELLPKIQETQPLVGAPSEKVFNILKGVELGDVLPPAPPVMPRRFQWSPASSIWLTSLLWGDIYVAGLTSIGAWKDTQVRLFGIKQAPVRGRGAQVNRVLKMMGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVC7</accession>
    <name>A0ABR3BVC7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutathione reductase</fullName>
            <ecNumber evidence="3 12">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_103368</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 12"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614250.1">
        <property type="nucleotide sequence ID" value="XM_066757866.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990224"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="14">
        <location>
            <begin position="15"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="13">
        <location>
            <begin position="366"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0250063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="479" mass="52233" checksum="745F5AB3A596E20D" modified="2025-10-08" version="1">MPPITKAQAEQVGEYDYFVIGGGSGGLASARRAGSYGAKVGLVEVSPRLGGTCVNVGCVPKKIMWYTADVAENLRKSAQYGFGKEGEGYKLAADFNWTELKHKRDAYIHRLNGIYETNLEKDHVDHHQGWASFVDANTVQIEPSNGDKYTVKAKHIVIAVGGRPTVPSEQKIPGASYGITSDEFFELETQPKRVAVVGAGYIAVELAGVFNTLGSETHLVIRYNQLLRSFDPMMSEVLVPCMEKAGMKIHKKTHVKKVEKTSSGSLLVHFDSSPEPIEVDCLVWAIGRHADTAKLGLDKAGVKYDKKGDVIVDDYQNTNVPGIYAVGDVGGKMLLTPVAIAAGRRLSNRLFGPEKYKNDKLSYDNIPSVVFSHPTIGAIGLSEPEAREKFGDDNIKIYKTSFRAMSFAMLDEDHKQPTAYKLICTGPEEKVVGLHIIGEGSDEMLQGFGVAIKMGATKEDFDSCVAIHPTSSEELVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVG8</accession>
    <name>A0ABR3BVG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615109.1">
        <property type="nucleotide sequence ID" value="XM_066756332.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988638"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="6">
        <location>
            <begin position="90"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="301"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="346"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="393"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="492" mass="53795" checksum="041BB52AD3C7E2C1" modified="2025-10-08" version="1">MGKRTSEAADLRVSKAAATGQETARNPAIDEEMGEFEDRWEDEIESEEEEIVVNDADAGGDDEFTPAQEDSESAPPATQTYLPGTAIADDEQLVPDNSVYLALHSLSYSWPCLSFDILRDSLGTDRATYPHTSWIVTGTQAGEVPGEGKAKDEVVIMRLGNLSKTQHDDDDSDDEDDDDDDEANDEDATLDFLTIPHVGSVNRVRAAPAPVGGAVPDPYHVATFSETGKVHIFDVRPYIDTLAGPSRPRQKLPVHTITNHGRAEGFAVEWGATGLLTGDIDRKIYLTTVTPSGFTTSPNPYLSHTSSVEDLQWSPSEPTVFASASADRTVRVWDVRAKGRKSVVSVEAHSEDVNVISWNKRVDYLLVSGGDEGALKVWDLRMFKNTPSPVAQFQWHTAPITSVEWHPTDTSVFAASGSDDQLTLWDLSVEPDEDEAPITSSADKHITAVPPQLLFVHQGQKDVKELHWHPQIPGMVISTASDSFNVFKTISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVN5</accession>
    <name>A0ABR3BVN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614920.1">
        <property type="nucleotide sequence ID" value="XM_066757451.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989805"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="283"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="495"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="535" mass="59722" checksum="BDFD9F2ACEB122BD" modified="2025-10-08" version="1">MANQPEKLANAQSKDAGEKAQGTEEKPVVETVPSVEEEILNNIALIGRAVNTIEPRFTIRVLRTLTSLRKKLTKNALKSVLDDAFPKGSKTGQTLIALPIFSSLPDSAPAATEKESDAMEVDTPVPATEGTAAEAGTSPSPKKKFVPPIDPATGDLLPEGIVYLRLLLILANLDAGRVVEAGDFATETADLISSWNRRTMDQLAGKVWFYVARAYELQGRLVELQPQFLAIRQTAALRKDETLEVTVLNLLLRSYLANSQYEQAEKLVSKAQFHGAANQAQTVRWLFYTGRLRAIQLNYAEARNYLQTAIRRAPKDEVAPGFVQLIHKYFIIVVLLTGVIPDRALFRKPVLKQALAPYFQIVQAVRIGDVAGFQKAFQTHEATFFADSTHFLISRLRHFVIKTALRTITLAYSRISFADVCIKLHLDSEEDTEYIVAKAIKDGVIDATIDPQGGWMQSKVAKDLYETDEPAKQFQKRVQYCTQVYNESVRAMRYPPNAHRKELDSAAESRERDREIAQLIQESDEPDDMDDMGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW37</accession>
    <name>A0ABR3BW37_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615323.1">
        <property type="nucleotide sequence ID" value="XM_066756546.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988853"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VHS" evidence="4">
        <location>
            <begin position="224"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="314"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="394" mass="44094" checksum="D9B8C688F4B53621" modified="2025-10-08" version="1">MAFQPFSPWIPPSIASSSILQRPNFSTREGFLNNVPNSSRSSTDSTWANAQQYTKTLSPPPQDYSNWKAKGLSPTQPQEILPPKFSSPFLPGLDVGPWSPPATQHQGRSFQGRSTPDIEERLVLADAKIQQLTLENRRLRQFIVNNYKDQQTSPPLESTLLEMKDSLSDSTTMSNSSFRQGHQRITDAFRADPFAEEDSSTEKSVYSAPQVVVHSVVQGTFNFATMPTYLIRAIVWTLAYCQPKNNHESTGLKTAVKALTARFGVSDSSEPSAILTKSIIDWAKPLCYTSCGNYLCQQLLERGTLEDKKAFLNQISDDIVPIASNKFGTHVLCKAINLKELEEPVAGALLKYGVYESMQTGARRLWREYLEKCRQARNLDVFQKQVIIYQASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW45</accession>
    <name>A0ABR3BW45_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614253.1">
        <property type="nucleotide sequence ID" value="XM_066757869.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990227"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1355"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="233"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1458" mass="160290" checksum="A77B9BBAF06C661C" modified="2025-10-08" version="1">MSPSPPPLTIPILLHPTLPSQASHALPLRPTHIAHWTAHSDHGQSAYTALAAQDNTIWVVADQPAPPLDDHDLLKEETSILIPSISTSSPISPRRSRPAPAQPRTPSQRPRATSTASTAGSSSQHRTCAFSPPFSAHQLPTATLSSATASAAPPDQHVHRSSLSGRMELMGQLREHNGGRESAGMGAGLGVGRRSLTGVHGQAEQNSGTTSPKSAMSLSTDTTSTAGLFSFWQKGSQSDAEEKEREMEEIMQEINVEREMEKERRESKKESEDLKAVEAAIERSPNPDQGYKITESHARSHGCEWGNKKIWRIVLRHVDRGKIASLKVIEELGILCVLRDQGLLEIFSLTTLQCVDFLELEGPNALHSQKDPSTGNVTTVKLGQVWCWSGILLARKDTSHMLVAHGLPWPCETPSHNGEVTRVMFLQFNQDQQPLLDPIAKLELPGEGAIGLCQDGDTNYLIHATPTSLTSYPIIFPQYKASCSGSLQLQPRHSSSAFPSRSHTPNPESSDASSSLLRKSASSSRLLDSHQSQAHEKEHSFARFLARRTDWSKKKDEEHGNQPIHPGLGEGKEVERDGYGHWTRTKLHENGEGVGWTDDGVDEFQCDGKSMWVKGTISWAERVSAREVVFSKNWARVVILRDDDMLAIYAPHDGEAPKKGSRLKFEQKFIDDGVNAICLTESGKLLLSNNNEVQTGDIDGPVTSFKTYLTVAEPPAEESGSFSHIVPYGLEDAFVADSQGNVCFRRLDSVIHQDNTDPVTDNKPTIDRLDAAVTCMKLIRGPEENDKMYLVAGDEDGVIRIWTVDEFQFCGSWTLFAWPVSGFVLLDMPQAGPLRGTLLCTSQAGTVGIISLSEMEQLFLIPAARSPLRYIYLGNSDILLAYANGKARVWNTETQEFRRSTGLDAAEDMLQAGNWTRVDLTKRHTQTPLTACVVQPYAASQLGRLLNLDLRGLGRWLHSSKNNPHHSPLPALRNLLSILLTFGVNDKVDEICTRNLGVHKPEKPILIGYGNADTHEIAYAHGVEAWQMSERITGMRQLAIITVLRPFLDSPDLERWAAEVIAFYTASLPPNIIEPDLEFFASYYMDPSSDVHQAARLLFAARVGRLSGSEIDTVVRIRQHELPILQSEERKFSGSAANALTVLGGIAVQKYQCMRPTSLKALSESVALYLHEPNCDHISLAVELCSKGFTTWQSYVDPSDLLRRLFHLATNKEPPSMSSHSSTSIAAQARLAILLVASSNPPLFMSTLSMDILDAKSAESRSSIMKLCVFMARKKPAVLENGLPRIAEAVVKSLDPNVGKMRDDVWQAATVILNELVLAFSTIDFHSRTQRLAVGTHEGAVIMYDLKTASRLYVLEPHKAPVSAVCFSPDGRRLVTVSIEGGSVTVWKVGSSLSGFFNVGGPPRQGAEKGEPFKRIEFMRADDRPLDSTSALSDVQITWLGARQARVTIKETALTFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW78</accession>
    <name>A0ABR3BW78_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome beta subunit C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615360.1">
        <property type="nucleotide sequence ID" value="XM_066756583.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988890"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="5">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="303" mass="31889" checksum="16F59DEC04B90711" modified="2025-10-08" version="1">MAKLAETPSVGFDFSNYARNQFLGQRLQGIPKATSTGTTIVGVIYGGGSSGEEPGVCLGADTRATGGPIVADKNCEKIHYLAPHIRCCGAGTAADTEFVTNLISSNLELHALSQGRQARIVTAMTMLKQYLFRYQGHVGAHLVLGGVDATGPQLFTVHAHGSTDKLPYVTMGSGSLAAMAVFESSFKEHMTRQEAIDLVARAIRSGVFNDLGSGSNVDVAVITKNGTEMLRNYETPNERGFKSRNYKFRRGTTAWTKESVRSLIVKEEVKSTSGAGKAQGAAEAVPVAVGAGPGGAEGMDIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWG9</accession>
    <name>A0ABR3BWG9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102117</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615445.1">
        <property type="nucleotide sequence ID" value="XM_066756668.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988975"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="951" mass="106293" checksum="1BE91BE16704E4E6" modified="2025-10-08" version="1">MSTNTPYRPHSHGPATRPPAASALSSLLAQANSLNEADYDSELPQIRFGIDDIERMSEVVAGRGKRIKSEKGEAFNLLSNLGVNTSQLAHSISQLPSEAAAPRPRRRRAAQVQAQAAEQVPELGRGFVAAEGDIGTWGRNWHEMVILSGIEMQRQRIINSFQKQFQQRILQNWQLEKARVLQDELGVTDDELAGIVDASRLASSALGSSSLGRSALGASARRFPMGQSTLGKSTTAESREGGLVMHTKMVRYERVIGELNQKRLRKEPYEFCQALSESTKNDSKNPLLWQSFNLLAHLVYEPSLRDSEYHGSSHSEAVPPVAEPVNERQYSAAYLGDQKAHQAALLRGRLVTGGLKYLERDFERHVDETIARNPKEAALGGVPGIRNKIRAFVDVTLRTKEAREAYKPETVNGTLLWAQTYYLVRCGYIDDALNLVAENQQHISRDDWSFPGCFKSAMQSPERRLSKTQRDQLYNDFNAHIRNNPLIDQFKAALYKLVGRFELNRKTAKVATTTEDWMWLQLNLVRENRDGDAPQEQYDLSDLGRLLEKYGCDKFDANGTKPLAWFNLLLFTAQFEKAVAYLYSKPQMKTDAVHFAIALSYYGLLRVPPKGDEAELLAVSDSSDVSFLNFARIIKQYIAPFFKLEPQTALQYAYLVMLNSDAPAPSGPKQRQLCLELVRDIVLSSRSWSRLLGSVRADGSKETGVIERDLKLLKLEDEQDYLRQVVLAAADQSSLDSSLTDSIELYHLAGSYDKVVETVNRALGHSLSQTAGAAPLPSDAAQVGLTVAFGGAPDLYSLAQKVHAVYERDFGKRTRVSSLHWETLETLLQLKLALAQFAADRPDLALETFKATNLLPLDNDPSSITRYAQKFRDMLDQPVISNLDDVIVTTMKCLHLLSQQLKQSPYGDQGRTAQLSVYKHQAQCLIQFASTLRLRLGPDVYRQLSSMSAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWH7</accession>
    <name>A0ABR3BWH7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_102628</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614640.1">
        <property type="nucleotide sequence ID" value="XM_066757171.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989484"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="458"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="701"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="133"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="255"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0250453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="794" mass="89275" checksum="F5050069413DC6CC" modified="2025-10-08" version="1">MAPKSRRATNSKAKATSTSAISPPEHSSPARSRAGSSSLSPIRSPKEDSDLDDNNELNPKTNESGLKAENEELTDASDRDEDLEEVHACPDNITFRYPSSVPNFTVLSQHEKAFKVARFLPCTAPSCACTGLEPPAGRTIKITKHGTSNEEDEDDEDEDDDVSMEDAEDPSEFEDRKAEWRTKEGWWRICGKCGHGWENGGHVWGDDVPPKERTRRGKVVGRIEEILEDENKLIEFPTPQSESISSLLKQLHEFVPPPAGKTTISGLPPPVDLSTPDDDTQGDHSDHERPRKRQRRASESTSSDIEEEHHRVQGKRKPGKGPAKGAKPRIPRTVVRGAHGFIPMATDPDGNQHVEGHLPISAGGAGADEDFEEEEEEEEELSTAKRPELDETERKRRTEIKVKEKEREEELVSRLAAGVNPEGGEGAVEIWEGIELQNLPLRPAAIEQANREIMLPVVSSRNPTPVATILLVGLKNVFQRQLPKMPREYITRLVLDKNHISMAIVKRGYRVVGGICYRPFEARGFAEIVFCAVDSSEQIKGYGSHLMNSLKDHVRKAHPTINVFLTYADNYAVGYFKKQGFTKEISYPRERWVGYIKDYEGGTIMQGRMLPKVKYMEVHQMLADQKAAIIAKIKTLTKSHIIHPGLQIFKERQPDEEIKLTKEQVPGLAESGWNPDLDDIVRQPKRNPYHVLLQHVLNDLQNEPSAWPFVKPVDSSVVADYYDVIKDPMDLSTMEHKLENNHYESIEGFVADVKLMCANCRQYNGEKSTYTKQANLLEKALDRILKKRKSVLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWL2</accession>
    <name>A0ABR3BWL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_102171</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615499.1">
        <property type="nucleotide sequence ID" value="XM_066756722.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989029"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0252779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="425" mass="47499" checksum="58BA88312C60FA0D" modified="2025-10-08" version="1">MVKLSPLALIFIAACFSRILHLTVLSGLSKALPLFDTSPSLLLPSPPPSLRWDAIHFSSIAYNGYEYEQQVAFQPGWLAVMRLAGEGVRFIRAASVVELKDVILGSTIMANFAFVAATLVLYKLTKHIFNPTFALLTSLLYLLPPTATPSAPYTEPIYSLLTFSGIYLLSIKRQMVLAGLCFAGATTVRSTGIFNLITLTCFAVFGDAHMLDLSDKDYAKRMTRKTWKHYLPALLVVAPFIMFQYYCETVFCTRESKLANSARPWCSNSPPVSYGFVQKLYWNVGPFEYWTLAQLPNIALAMPILSFSLVGFVKYFSHLVSSSQVLNHGTGEKPPPPILFELYSVHLLTMALLLFTSHTQIALRVCLGDPVVWWNAVKLGFDNVEMDEGRKRHVKMNKFGRYWVGWTVVWGAIAAVLWAGHYPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWZ7</accession>
    <name>A0ABR3BWZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="5" type="ORF">I308_102304</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615631.1">
        <property type="nucleotide sequence ID" value="XM_066756854.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989162"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="550" mass="60421" checksum="7D8E85CFFAACD513" modified="2025-10-08" version="1">MSCGDNDTQEQEQLMPRRRQVRRVDKSICQKCRQTKSMYIIRNVTFCKTCFEAAVFSRVTKSLHPPLKPATSSKSAASSGYRPPVQPGSALIALSTGCGSTTLLDLLLTRQYIGKGDDRVIDKTKGEKEPVWRKGWVCYVDFSSVVDEVERQDEGQGQREGSRMEEVEKWVEERENGLGWVGLKAEDVFDKGLRNRLRALTGLPIQDGNEEATVQWAVDLKDHALPLSSPSSSSSSPPTTPLTHLRNLLTSLPSSSRPQLLTHILSSLLTTVAHTLPHISHVLMGETSTRQAERLISGTALGRGWQLPLELAAVRVEPALPSPGHLITSAKAKGKESEIQGFTWLKPMSDLTAKEAAIYCHLRSLSSFTYNARHWDSAGSPHGVGKTKGGVKSLEMLTENFIAGLGASHPATVSTINRTGGKLVFPGKEEGRPYCPVCQMPVDPSALAWKSRTALTSLSTKTQPITISKEQQHQHGETETLAPLLCYSCLTTLTPPTVVSKAKTRTQMAGLDVNGDEPILLPVWVNEGVKRRQVGREKMKDEIKDFLIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYQ8</accession>
    <name>A0ABR3BYQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-hydroxyacid dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615739.1">
        <property type="nucleotide sequence ID" value="XM_066755453.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987748"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF289">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="62"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="126"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0253518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="36911" checksum="F2F05835D0A5350E" modified="2025-10-08" version="1">MALSNAPKVLFLDTIKLAKPQLSSFSKIANVIPNTSKTREEFLHDLGTKYKDVTGIYRHFKASESIKITGRFDEELVSKLPSSLKFIAHNGAGYDQIDISPCTARNIQVSNVPSAVDNATADTAIFLLLGAIRNFSRALLHARQGTFNSQLPLSHDPEGKVLGILGMGGIGSALARRAKPFGLKVQYHNRRRLAEEKETETGATYVESMDQLLATSDIVSLNLPLTAATRHLISDDAFSKMKTTSILINTARGPIVDEAALVRALESGKIAGCGLDVYENEPRITKELLDHPNALCLPHVGTVTVETQTEMEAVCLRNLEHGLKTGKLAFTVPEQAHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYV2</accession>
    <name>A0ABR3BYV2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM3</name>
        <name evidence="11" type="ORF">I308_100945</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615793.1">
        <property type="nucleotide sequence ID" value="XM_066755507.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987803"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0253572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="95" mass="10522" checksum="B947294B74FD9647" modified="2025-10-08" version="1">MDAVVDSQIQEPLDLVKLALGERVLIKLRGDRIVTGILHAYDAHMNVVVSQAEESIHIIDVTEEGQPLPPRIERRSAEMLFVRGDGVILLSPAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ50</accession>
    <name>A0ABR3BZ50_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pre-mRNA-splicing factor CLF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_101038</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615884.1">
        <property type="nucleotide sequence ID" value="XM_066755598.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987896"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="13">
        <location>
            <begin position="62"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="12">
        <location>
            <begin position="227"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="682"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0253663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="726" mass="85572" checksum="DB390C1CD8EFBA12" modified="2025-10-08" version="1">MAGRDPRDRAPRVRNRAPAAVQITAEQLLREAQERQEPAIQAPKQRVQDLEELSEFQARKRTEFESRIRYSRDSILAWTKYAQWEASQNEYERSRSVFERALDVDPRSVDLWIKYTDMELKARNINHARNLFDRAITLLPRVDALWYKYVYLEELLLNVSGARQIFERWMQWEPNDKAWQSYIKLEERYNELDRASAIYERWIACRPIPKNWVTWAKFEEDRGQPDKAREVFQTALEFFGDEEEQVEKAQSVFAAFARMETRLKEFERARVIYKFALARLPRSKSASLYAQYTKFEKQHGDRSGVELTVLGKRRIQYEEELAYDPTNYDAWFSLARLEEDAYRADREDGENVEPTRVREVYERAVANVPPALEKRYWRRYIYLWLQYAAFEEIDTKDYDRVRDVYKAAVKLVPHKTFTFAKLWLAYAYFEIRRLNVSAARKVLGAGIGMCPKPKLFTGYIELEMRLREFDRVRTLYEKFLTYDPSLSSAWIQWTQVESAVEDFERVRAIFELAVQQSLDMPEIVWKAYIDFEAGEGERERARNLYERLLERTSHVKVWISYALMEIATLGGGEDEDGNEIEGEAGDADLARQVFERGYKDLRAKGEKEDRAVLLESWKSFEQEHGDEGTLAKVEDMLPTTRKRWRKAEDGSGELEEYWDLVFPDDEKEANPTSFKFFQAAQAWAQQRAGQGEEGGLSYDLPSDSEGENEDEDEGADHREEDGMDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ88</accession>
    <name>A0ABR3BZ88_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615924.1">
        <property type="nucleotide sequence ID" value="XM_066755638.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987937"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.15.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28252" checksum="4A2865E8041C1E2D" modified="2025-10-08" version="1">MAPSTTVPTAEQIAVPETLLKKRRTNEASREAKLAAAAEARKAQKAKRKVIFKRADEYVKEYLNAEKEEIRLKREARKTGDFYVPAQPKVYFVVRLKGISKIAPKPKKILQLLRLLQINNGVFVRVTKATQQMLNLVNPYITYGEVNLKAIRELVYKRGYAKVDGQRIPITDNAIIEKQLGKYGIICLEDLVHEIATCGPNFKQATSALWPFKLSNPTGGWRPRKFIGYVEGGDAGNREKAMSKLVHQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZR4</accession>
    <name>A0ABR3BZR4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">isocitrate dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_101256</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616099.1">
        <property type="nucleotide sequence ID" value="XM_066755813.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988114"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="14">
        <location>
            <begin position="50"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0253878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="379" mass="40607" checksum="C2B6A128ED1C1069" modified="2025-10-08" version="1">MFARSASKNVVSSLRSVQAPVGVRYYASAFNSSTPTSAFAGKKGADGNYTVTLIPGDGIGPEIADSVKKIFKAAQVPIVWEEVDVTPILKDGKTVIPDDAIRSIKKNTVALKGPLATPIGKGHVSLNLTLRRTFSLFANVRPCVSIKGYKTPYDNVNTVLIRENTEGEYSGIEHEIVDGVVQSIKLITREASERVARYAFHYASESGRNKVTAVHKANIMKMSDGMFLTACRDVAKEYPNITYDEDLLDRVCLRIASDPSPFADRVMVMPNLYGDILSDLSAGLIGGLGLTPSGNIGKDASIFEAVHGSAPDIEGKGLANPTALLLSSLMMLRHMGLNELADKIEKAALSTIAEGKAITRDLGGKAGTKEYTDAILSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZT2</accession>
    <name>A0ABR3BZT2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615857.1">
        <property type="nucleotide sequence ID" value="XM_066755571.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987869"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19530">
        <property type="entry name" value="RecA-like_NVL_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="128"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="454"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="701"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="767" mass="81894" checksum="4510148AC40FA0F7" modified="2025-10-08" version="1">MSGLPSLNSGITAAWNTNPVPQKKRARRAIPLNDISATDTPADSPAASASASASASVSVQDDQPTPTPPAPRRKRPRPDPSAIAAKYAPPDLDLGSLGGLQPQITQLLEIAALALFHPEIYLHTGVPRPKGVLLHGVPGGGKTQLVKCLAGEMKLPFISVSAPSIVSGMSGESEKTLRDTFDEAKKIAPCILFLDEIDAITPKRENAQREMERRIVAQLLTCMDDLAASEEPVIIIGATNRPDSLDPALRRAGRFDHEIEMGVPSQEGREQILKVLCSKLRLSGDVDFRQLAKATPGYIGADLTALTTEAGVFAVKRIFNRGIGNGLSTNTITGAEEIPEPDGAGIEAMMIDDRDTPFANLPEDVKKTPIAKFLMSHPTALTSDQLSTISLTPADFLAALKIVQPSAKREGFATIPDVTWSDIGALSQTRDELHMAIVQPIRHPELFSVVGIDAPSGVLLWGPPGCGKTLLAKAVANESRANFISVKGPELLNKYVGESERAVRQVFARARSSSPCVIFFDELDALVPRRDDSMSESSARVVNTLLTELDGLDARKAVYVIGATNRPDMIDPAMVRPGRLDKLLYVDLPSPSERFEILKTHTKKTPINEDSWENIKQIVTSDKCDGFSGADIAALVREAATLALRAALESIGAFETPAEAEPEGVERKTDSVKVTAEHFARAAQKTLPSVSREQRLKYERMRDKYAGVPTRGRKQREAEAAAAAASAATSAGAGGGAGAEAKVEGEGMDVDEMGGARGGVKEKAFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZT4</accession>
    <name>A0ABR3BZT4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pre-mRNA-splicing factor RSE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101271</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616114.1">
        <property type="nucleotide sequence ID" value="XM_066755828.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988129"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="4">
        <location>
            <begin position="14"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="5">
        <location>
            <begin position="464"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="3">
        <location>
            <begin position="862"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1217" mass="134035" checksum="75930DA858B2C820" modified="2025-10-08" version="1">MHLLNLTLSSPTNVSTAVVGSFSGSKSQEILCVRGGTKLEIFKLNATTGQLDTIVSTEAFGTIRNIAGFRLAGMTKDYILATSDSGRLSILEFVISPTPHFESLYQEVFGKSGSRRIVPGQFLAVDPKGRSCLVGSLEKTKLVYVLNRNTDGKLYPSSPLEAHKNHTLVTHVVGVDQGYDNPLYAALETDYSESDQDPTGEAYENAQKHLTFYELDLGLNHVVRKWSEPTDRRANLLVQVPGGQNANSDRFEGPSGVLVCTEDHIIWKHMDVEAHRIPIPRRRNPLVQRGDKSRGLIIVSAVMHKIKGAFFFLLQSEDGDLYKVWIEHNGEDVVALKIKYFDTVPVANSLCILKRGYIYVASEFSDQNLYQFQSLAEDDGEQEWSSTDYPENGNIDGPLPFAFFDPQPLRNLLLVDNVPSLDPITDAHVVNLLGASSDTPQIYAACGRGARSTFRTLKHGLDVAEMVSSPLPGVPTNVWTLKLTEDDEYDSYIVLSFPNGTLVLSIGETIEEVNDTGFLSSGPTLAVQQLGNAGLLQVHPYGLRHIRAADRVDEWPAPPGQTIVAATTNQRQVVIALSTAELVYFELDPEGSLSEYQEKKALPGNATCVTIAEVPEGRRRTPFLAVGCDNQTVSIISLEPDSTLDTLSLQALTAPPTSICLAEIFDTSIDKNRATMFLNIGLMNGVLLRTVVDPVDGSLSDTRLRFLGAKPPKLVRANVQGQPSVMAFSSRTWLLYTYQDMLQTQPLIYDTLEYAWSLSAAMCPDGLIGISGNTLRIFSIPKLGEKLKQDSTPLTYTPRKFISHPFNSVFYMIEADHRTYSKGAIERIVKQKESEGRRVDTLLLDLPANEFGRPRAPAGHWASCVRVLDPLANETIMTFDLDEDEAAFSIAIAYFERGGGEPFLVVGTGVKTTLQPKGCKEGYLRVYAIKEQGRILEFLHKTKTDDIPLCLAGFQGFLLAGIGKSLRLYEMGKKALLRKCENNGFPTAVVTINVQGARIIVGDMQESTFYCVYRSIPTRQLLIFADDSQPRWITCVTSVDYETVACGDKFGNIFINRLDPSISEKVDDDPTGATILHEKSFLMGAAHKTEMIAHYNIGSVVTSITKIPLVAGGRDVLVYTTISGAVGALVPFVSSDDIEFMSTLEMHMRTQDISLVGRDHIAYRGYYVPIKGVVDGDLCESFSLLPYPKQQAIASDLDRSVGDVLKKLEQMRTSSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZZ3</accession>
    <name>A0ABR3BZZ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secondary thiamine-phosphate synthase enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616174.1">
        <property type="nucleotide sequence ID" value="XM_066755888.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988190"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="144" mass="15773" checksum="055E70E1A5302320" modified="2025-10-08" version="1">MPWQKTFSLPPHRKGMHLVTSEVIQNCQEGLKNVDIGIFTLHCLHTSAGLTLNENCDRTVRTDMDMALDTIVPESLPWEHTDEGPDDSVSHLKTSLIGNSITVPISKGKLVLGTWQGIYLAEFRHSGGGWGGQGQGRKVVATIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C014</accession>
    <name>A0ABR3C014_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="14">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I308_101352</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IND107</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="14"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616194.1">
        <property type="nucleotide sequence ID" value="XM_066755908.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988210"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1031"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1071"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1114"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1148"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1179"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1222"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="211"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="305"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="1000"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL0253973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1306" mass="146673" checksum="ECA4466722525909" modified="2025-10-08" version="1">MPAQQQDPFDDLLGSDSPPTDPVPPRSDSFHEGRHIDFFHQGGSPTRAPAAFSRRGPSPDSVSQPTYALDPFFDDDDEYGPDVAHSYSGYFAPHGSQPLGHSNPSLLESSVPLANAGAIPAGFSGPMDDVDIRGYQASPSRDYAAEDPFKDDEGPSAYAFTAPGASTGWTQPRRGRWQIFRDEYLTDVDWSLGLNQLLRRKSKFDGVPREITLNEPEENRLRGFEKNSVTTGKYGPITFLPKFLLSEFSRSANLFFLFTACIQQVPNVSPTGHWTTIVPLGVVIIASAFKEIKEDFKRHASDRSLNNNLAQVLVDQKFQLRPWRRLRVGDIVRLEANSFIPADMVLISSSEPEGLCYVETANLDGETNLKIKQAHPSTASLTDPHSVSLLRGHILSEPPNSSLYTYDGTFHLSSAHPGSAPTKIPVGPNQMLLRGAQLRNTGWVYGVIVNAGHETKLMRNATEAPIKRTAVERQVNRQILYLFLLLIVLSLVSTIGSSIRTWLFDKNAWYLRLDDESKNKARQFIEDILTFIILYNNLIPISLIMTMEVVKFQQASLINSDLDMYYAPTDTPALCRTSSLVEELGQIAYIFSDKTGTLTRNEMEFRECTIFGTMYAQTVDDGKRDQGQRTFDVLRQRAQEDSQEGDTIREFLSLLSICHTVIPEEHDGKMAYQASSPDEAALVAGAEMLGYRFQTRKPKSVFIDVNGETHEWEILNVCEFNSSRKRMSTVVRGPDGAIKLYTKGADTVIFERLAPKQEFSEPTLIHLEDYATEGLRTLCLAYRDISEEEYSSWSALYNNAASQMSGRAEALDKAAEVIEQNLQLLGATAVEDKLQDGVPDAIHTLQQAGIKIWVLTGDRQETAINIGLSCRLISESMNLVIVNTETAVETSELLNKRLFAIKNQRLGGDTEELALIIDGKSLTYALEKDCSDVFLELAIMCKAVICCRVSPLQKALVVKLVKRSTDAPLLAIGDGANDVSMIQAAHVGVGISGVEGLQAARSADVAISQFRFLRKLLLVHGSWSYQRLTKLILFSFYKNITFALTLFWYSWFNDFSGQIAFEGWSMSYYNVVFTILPPLVIGIFDQFVSARMLDRYPQLYHLGQQNYFFTPIRFFYWVGNAFYHSILLFAFSVLVFNNDLLATDGKNSGLWVWGTTLYLAVLLTVLGKAALISDVWTKYTLAAIPGSFIFTMIALPLYAIIAPLLNFSLEYTGIVPRLWADPVFYFVLLLFPIICLLRDYVWKYYRRTYHPASYHIVQEIQKFNLSDYRPRQEQFQKAIKKTETNNQDQARLIRAYDTSVARPSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C049</accession>
    <name>A0ABR3C049_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615977.1">
        <property type="nucleotide sequence ID" value="XM_066755691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987990"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="247"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0253756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="566" mass="63228" checksum="DAB5D2456C115761" modified="2025-10-08" version="1">MPPSTRPHKSSSPRRKSAHPYHRPPSSVPAAQPLVLDTKQESLNTQDKQHVSDDSVHLSVPETSLSRGSEKRKKKNKRKKNKKSRAMQLDAIKSSYAPPSGPLSPSKPLQIKCGIDITSPISHSGITDPALLPLKHNTPLISLELSSDNGPVSDKARATNLNRDIARLREEAQKREAVHLELSKAHEEAGRLREKVENITKREDELKARVEELERAVEANNQKTKILDTAMQQHDSTKKDLTEALTCTVCFEILRDPYMLSCGHMACKSCLFDWFRSPGAYRRPPTPITSISNLSYYTKICHMCRCIIVRRPTRVFFLRSILEPLGLHQDDPPPPLASHPAESSLSAASDPWKLIFPPDPTTYKLHDDDDHCLRCPECMGEVEDGCCFSCGINFSSDSEMEGQSDEDFDGLDGDSWPSDEGDESRGAFFQHLFRFHPHLTNIYNQRHPLGIDVDDDESDSDSDSMLVMEEPPSHVSVDNMSVDENVITDSDGYEDSFIDDEGEESYSEDDSGDSDVVLLDNEDRPLRGGPPPRVRSVMSESGNESDQPVFTGRTRRTAGRVVSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0C9</accession>
    <name>A0ABR3C0C9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100979</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615826.1">
        <property type="nucleotide sequence ID" value="XM_066755540.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987837"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF32">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0253605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="506" mass="56741" checksum="76B1EC23AE9B4141" modified="2025-10-08" version="1">MASSPVPFHGIDNGYSRPQSDISSNEKYEREKAEYTSTSILATKDWTDAEEKRVVLKLDLTVMALLVFGFFCFQLERGNVANAVSSTLFKDVGITQNQYNTGQGLLYLGIVLLEVPSQMVVQRIGPQKWLTFQVLAFGLVATFQMFMNSYGSFLATRILLGICECGYIPGALYTISTFYKRSELGGRNAVLFIGNVLVSGVGGLMASGILRLHGALKPWQYLFLIEGSLSIFCFFVFLTFLPNSPQNPFPLLFKRLTLFTPREREIILARVIIDDEHKFDSHRPLTRQEIFGTLGNWRNYPHVLAAISLISTTAAMGQYLPTLIKGFGFDTIKANALSSVGGWISLVLMITYGFVSDRFKNKGPIVILACFPYLILWIAFQSESSTSNRWAKYVTLTLTSGYSVCWHPLNATWLSLNQKTPQQRAIAMAMFIMAANLGGLVGSQLLRANDAPTYPIGFRVTLCLAAFGNACVIFQHFQYRWSNKRNEQKIAQGEKLREDRVVTYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0D2</accession>
    <name>A0ABR3C0D2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616308.1">
        <property type="nucleotide sequence ID" value="XM_066756022.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988324"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="850"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="940"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1201"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="473"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="857"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1354" mass="145929" checksum="00EF6B6775A696A3" modified="2025-10-08" version="1">MSRAPSPAIPDTSQSTFPPRPSIPSSDAAFATPGISSTSSTAPTPTLALPGLRINVDSLPDRSRSNSTLPSFSPSHSPSNLSPNASHNLSLAPEHRPRSNSNTTDSSIPINASNPADGSDQHDVAMAVRNLRSASPPPPPPKSANRLRANTSPPDSGAMTPAFTPGIGGLGQAGVESSAWSSALVSNEEERTLRMIKQALEKSDDDGDTLDLSRRDIDRIGEEAVEMFKSGVGKGQKGVWRLALSYNFLRDGSMVDSFSKLSRLRYLNLKGNKFTQFPHAITQMPALEILDFSKNELSSLPELPGHLVKLKVLSLTSNKIQTLPSYLVEFGVLKVFKVDQNPVDWPPARVLGPLIESVSTRSKTSSAPGGKKKVKEEDLRPWIESMKIWMAQQTPGSENERRRGEEEAYLASEEEPSSATSIENPGVTEWPEASENTMVAPSSQATIRRTYPLRGDTPDLAFAQRNISTTFSEDSLLRSSSPSHFSPANHSRNASVSSFTSPPSASTDASFHSHSRNPSTNLPHLATQSVQGHTRGASYTPAQRNSGQLTAKKSLPDLRQSHAKIIHERRGRDSGEDGEGEGMVPVMAPAIVPQEIMGVRSPPHLASALPRRASRMIGRKASVDLLIRKMGEMTSHDMADRNASHDDILDESRNSYFRRLSTLPASSISKAIPPFLLKFIDSIRGILFALSQLHSSLRQYLVFAVNERVSSVFGRVMEPAGMYMNKLINALDRFDSMSRRGTPPTQAIQNLFDATKESVAVFGKVLAVLKMQVPAMRGNDARYTRTLMVNVYGAMAEVASSWKTMTAFLPEVKMLLFMDAPALGMRCAMGGHKMVASGSFTGRTPISPIIERRESHSPQSATLESSPPNLERRQQQQAEIDVSPTAHAERRAGVRGHGVGTERRHAGSYSSLDVERGMMMGSPLAKSMSIGVREDEGHKIGESGTIHLPPPDEEDEADEERYSSMRHMLGAASPQSMSGRTSQHRHRPTSSAGSSNALYLPPSLSHSSRQLSVDIRAPASASATLFDEDLLDVIDTATEAAFACWLKLSEEIGAVSPQMNRSTHRNNSSISSVSSQSQDHLDLARMALPLFTPLGAHSRRPSTISPKAHAELVHNLSVAEQITAALRESLLHLRADPHAYSYTTLPDDTQSFIKIVVKVSELVKAMSRTHAFPVSVRQAVGKLTQATRECAILIQVSSLKPGQGTAAPTAPLSSGRSVMPISRAGSATGIGTGYISSHHGPESSTDDLSHLHPPSSTGPSHVSTPLYTPSSSTTSFEHFHYTSSSSGVTTNASGLRDLQLPSRLGHASFGRNRSGNGSAQMTLPSIQMPVPYVNGGAVGQANQPRSAQASQVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0Q2</accession>
    <name>A0ABR3C0Q2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616425.1">
        <property type="nucleotide sequence ID" value="XM_066756139.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988442"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0254204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="69" mass="7514" checksum="5EF79B88E8137D08" modified="2025-10-08" version="1">MGVHSLLPAAYSLKQARTEEDSGPCTTTTNIRVIIHKKNYSVATSTLLPPYTPAIPSPQPTPYTYPRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0S5</accession>
    <name>A0ABR3C0S5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616250.1">
        <property type="nucleotide sequence ID" value="XM_066755964.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988266"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="361"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0254029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="780" mass="85027" checksum="634AE0ACED18CF0F" modified="2025-10-08" version="1">MYSSRQIDQPSQLSQHVNAEATVSSTHPQHYCMPGSQTVFNSVAVPPSPSFSLSPEVQPIPAHHSYPPSFCPSGSPCLSDSPHMIHYGISSPIIGSYPESQSSPRVSSRAGDSHVIVHHWGPVQGISGSQIIVKCDTETAFLSRPGRSVTPSAGGPGQMTKTLRVVFGSYPVLTKVENLKENIDRNTSFLRVTVPDWSLTGAASDDTGGGGIVPVSLQILADDINILETVPLGHFIYTEGVTPKCNVDYLESAKHSSPIPAIQRRTASGPVSIPELQSYSSPQYLMHSRPPAIRHVSESYVPSIHKTYAQSSQTFQPSIPLSNISNSASFRSQPNLMRSSHVIGGAPAQSTSTTLISSGHKAALSITGDLSTVGKGWTTEEWHTRRRLVQFWRRQEGTTIHTQFRVISQSEWSSNQSSIVISCVFWEEKNSCYITSVDIIYLLEALVGTHFTVEEKNRIRRNLEGFRPITVDKSKPDTESFFAEIMNLPNPRPRNIEKNVKVYAWDCLEAALQKIIGKYSASLPTTHSSSVRPIMTPCPPSTSISMPSTTLPTPSSLPEVGSPLKSYNHLPNSLFATSARHTHHGMPPPLTSRSSDESFYGIQQLNSRQPQPSSTRTSSSSSVTQITTPVQPFFSGTTSSPRSMYSSNVGGSTSHVTQRDEKTDGNADIGLYFNMPPVYSQAVNATDNANHSLSGPIPPSPSLSEMYSAPFHYPSPSSYVQFQSPYTPSVAHVEQQQAAQYHGGLRQNHNARMVFSTYPDIQGQGHGGIEAKIKSLHTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0U4</accession>
    <name>A0ABR3C0U4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616232.1">
        <property type="nucleotide sequence ID" value="XM_066755946.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988248"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0254011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="671" mass="75320" checksum="CC61A673DADBF6C0" modified="2025-10-08" version="1">MSLHRYFARPPLALAIHPAPPSRPKVTNKDRDDKAKVNLQAKADEGQQDQKAPGGKGARCTPAKCDATPEKNNEVVPTPVSPGSNLPEPPTPALGAIISDSHKEADAKQSQPERKDGDQIGINDNTSKLTPGQIPEVLAEGKDNGAAHMHKAPDSEPEPLVLLSPAPNRPLRARLDLSPSVVYPPVNTDPRGAYHKYAKAVGGEVVYVDVTKDGWMTQQWKERNEREAMKRLTGEWERELQKEVEKERKRAIKKTVPKTSEGLLLDLWNELVEANNHELSANEFWDRYDWSHSGARKHLRSDVKRPETSPGQDSKTSSHARTIAQKPEIEWTREGVEDILSTVGIQCAYNTERPPSRHWSEPAAAFLLFTHGFFLLRLDFAITWKPEDQIKKGFQGLITNSNDRVFGEMVKDQQAEDRKRKEKEYKERKEEERKGKEKEEMQKQQKTGADETPVVPDAASNAKVLVGEPVVPTCVAEPTPDKAIIATPDITVSDVNCKNKKSQAKQQVVHYDIKHDVEAELVPRPKAADCTRNKPSEVEKKKPKEGDAKALERAIEPNDAGGFDGANMATRALELAPGDDVLATKPNNTKSSAKDNKSLVKKDRGPLFWTWTEKCEKWRWRNYDAGVHIIGPGGWEERDWQVFADGKKVEDWDIQQENIEKQEIDVHDWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1R9</accession>
    <name>A0ABR3C1R9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100866</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615715.1">
        <property type="nucleotide sequence ID" value="XM_066755429.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987724"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF83">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0253494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="646" mass="71244" checksum="538B9CCAA0AC519A" modified="2025-10-08" version="1">MMSAASDEQGKRPRPQRQGIRTHITNACEPCRTKRAKCEGGGPCPRCKRLSLNCSYKDDGRRSNSLQRSFKVLKGEVLRLRSILENHGIPYEVEAADNPEDLNGIMATNGEEAEVVSRKCTPSVSIDSGSSPQGLYRDSQSGQLVHYGPSSFHSILAESGQDQAILPSTSTGLPITGQEPHIINFSNISPELHGELLDLWFRYINGYSVYVDQDTFREGCTTGIPSHSYSRLLHLAILAEASHISSHPGLRSNPHDPSTSGIGFLMEAMSLLQMEMEPRQTTAVALCLLCATLSDSGQEFLSWIFGGNSWRISQHLGLHLDGQTNADDVKHRRQAMWGVFFHDKLITLYTGRACGMQFEDLAVPLPTYPSPAGTTVWDAGPVYLDECTNAAFARLSVVAGHIMRDIYGVRAQHHRMSRTVIEALGNDLLNWAKTLPPPLQDAPEGIRSQSPRILFLHTTYRSLCLLLNRPLLRQQTSHRNRVREKCCEAAIRMADLLALYNALHGLNRAPISFTHNTYTAATTLLLLHLDEPTAEGRANLSSSFTKTISALTSISTSWSLARKAIISVEFLVKEYLGGSKDASDARLLKVVVDAREKVRPHTFNWLEDAQGQGDAGFDIGFGFDLDAYLNGDLFLSQSLGMEAPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C308</accession>
    <name>A0ABR3C308_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="11">IMP dehydrogenase</shortName>
            <shortName evidence="11">IMPD</shortName>
            <shortName evidence="11">IMPDH</shortName>
            <ecNumber evidence="11 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_101292</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 14">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="11 14"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616135.1">
        <property type="nucleotide sequence ID" value="XM_066755849.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988150"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 14" id="KW-0520">NAD</keyword>
    <keyword evidence="7 11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11 14" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 11 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="194"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="11">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="288"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="338"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="11">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="11">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="11">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="378"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="401"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="425"/>
            <end position="429"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0253914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="544" mass="57942" checksum="65E9D0BA6F482E78" modified="2025-10-08" version="1">MSGTNPNAPPRSNSILNPADALRYLEEYPRGDGLSLQELMDSRKNGGLTYNDFLMLPGHINFPASDVSLQSKATKNIVLNTPFLSSPMDTVTEDRMAIALALHGGLGIIHHNCSAEEQAAMVRRVKKYENGFITDPLCLGPNATVGDVLEIKTKFGFCGVPITETGEPDSKLLGIVTGRDVQFQDPETPIKSVMTTEVVTGTSPITLEKANSLLRETKKGKLPIVDSKGHLVSLVARSDLLKNQNYPYASKVPESKQLYCGAAIGTRPGDKDRLKLLAEAGLDVVVLDSSQGNSVYQIEFIKWIKQTYPKIDIIAGNVVTREQAAQLIAAGADGLKIGMGSGSICITQEVMAVGRPQGTAVYAVAEFASRFGIPCIADGGIGNIGHIAKALALGASAVMMGGLLAGTTESPGEYFYHEGKRVKVYRGMGSIEAMEHTQRGSASGKESILALDNAATARYFSEADAVKVAQGVSGDVADKGSINKFVPYLFTGLQHSCQDVGVKSISELHSCARSGSLRFELRTASAQLEGGVHGLNSYTKRLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C373</accession>
    <name>A0ABR3C373_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calcium/proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101353</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616195.1">
        <property type="nucleotide sequence ID" value="XM_066755909.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988211"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="60"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="264"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0253974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="373" mass="40346" checksum="0BAE29E78F9FA46F" modified="2025-10-08" version="1">MATLETSPLLPSQASEHTPVSKPFDLLGSTRYLLLGSWINVLLICVPLSFAAEGFNWSAAARFTTSFLAIVPLAKLLGDSTEQLSMKLGQTLGGLLNATFGNAVELIVAIAALRQDELDLVQRSLLGSVLSNLLLVLGMSFFAAGFFFYESTFQATAAQASSSLMTLACITLILPAAYHASEIDNSSSLVGTLLGKEVSDLPDRSLKGLLLLSRGTSVILLLTYFGYLYFQLRTHSGLFEAETEEAEEMEVAEMDQWSAGTWLFIGLILLPLVGNAAEHVTSVWMACKGKMELTIGVSVGSSIQIAAGMIPLLVIIAWPLQKDLTLFFANFETIVLFVSVMLVNLLLQDGRSNYMEGVMLMSLYLVIALSYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3K5</accession>
    <name>A0ABR3C3K5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616498.1">
        <property type="nucleotide sequence ID" value="XM_066754597.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986875"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF20">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="7">
        <location>
            <begin position="56"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="376" mass="40359" checksum="8C0AF7DB27C05D3D" modified="2025-10-08" version="1">MPSSTRVSVRDAMELLDDRRVKIVRPLIPPQILHEELPLSLRGAQTVLDGRRQVEAVIKGDDDRLLVVVGPCSVHDPEQAITYAKALKEYADQAAEDLVIVMRVYFEKPRTTVGWKGLINDPDMNGSYQINRGLKIARKLLLDITEIGLPAAGEFLDVISPQYLADLFAWGAIGARTTESQVHRELASALSMSVGFKNGTDGSIGIAIDAIKAAGSGHTFLSVTKQGLSAIVETEGNSSTHVILRGSSKGPNYGADDVAACAEKLNKSGLPAKIMIDCSHGNSSKQHLNQIKVGADIASQLSSGPTSNVIVGVMIESNIYEGRQNVPVEGPSGLKYGISVTDACISMEQTIPLLDELRKGVQAKREAVKAKREGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3N9</accession>
    <name>A0ABR3C3N9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="11">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_101488</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="11"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616330.1">
        <property type="nucleotide sequence ID" value="XM_066756044.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988346"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="162"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0254109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="608" mass="64784" checksum="90FD7C8883047282" modified="2025-10-08" version="1">MQVTSLLRFSGVCPFLGHSTPSSLRAMANTANSSVSALTATAMTCPMMGPKLASISAARTYASVAGAKEVQQLHQNKNVTIDSTATGAAAKCPHAKAANDVAVDAHRKAVTAGTFDYQKFYDTELEKKHKDKSYRYFNNINRLAAKFPVAHTANTKDEVDVWCANDYLGMSKNPVVIGTMKRTLDRYGSGAGGTRNIAGNGALHLALEDEIASLHRKDAALVFSSCYVANDACLATIGAKLPGCVIFSDASNHASMIQGIRHSGAKKVIWKHNDLADLEAKLKTVPKEVPKIIAFESVYSMCGSVAPIEAICDLADKYGALTFLDEVHAIGMYGPNGAGVAEHLDFEAHLATRQSSEPVKGSVMDRIDIITATLGKAYGVVGGYIAGSADFVDVVRSYAPGFIFTTSLPPAIVAGAQASIAYQREFMGDRRLQQLNTREVKRQFNQLDIPVVPNPSHIIPVLVGDAALAKEASDMLLAKHKIYVQSINYPTVPVGEERLRITPTPGHTKEQIAHLVSSVDNVFNTLGLKRVKEWKAAGGRAGVGMPNASPIEPVWSDKQLGLTDGSAPVALQQGAKSVVRDEAAQVAQKRLTHLLGAEAGPALKVASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3Q0</accession>
    <name>A0ABR3C3Q0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616527.1">
        <property type="nucleotide sequence ID" value="XM_066754626.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986905"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="145"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56192" checksum="342B23582BE5758F" modified="2025-10-08" version="1">MSSRLPPSSSHSIKFGHAQSTSPSKSSTFGQERNDGVLDWLDYAECSLCRDPLLNGAAKGKCYWMTSCGHILCSSDDHQRKSACNKQMELFIIQEGSLPTGHEMWFQNGVSLLSGAMEEIRTAVKKNISALRVMGFQYREMKRSIQHYKSAMKEKDAQIATVQREQETLLSKNHELHERVAELQSGLRNLQRSQPAVVPQITPQSQYSLNSNARQAELSHYNQQQSNTRKEYMPPPPALPTVQEEEKQQPAVSFGYGMGKGDFEGSNKKRRIDILEQQPRRFVPPTPASGASEGPVHLQHPKPSHNFQPTRPISRAFSSTAPRAIPRMEALPQVPFLSPEGRQQNTMHFRRMRDERNADGGGDVKSRLDAYRYDPANTSPNRPAPQDRPGTTLPNRHEPTFSAQPLQTQPPQMSVPQRPQSSFIERLKMSNSSFMNRPGSARPTPLQHHTSASSMDVTRSMVIGTGMSMVQGSAGVRTREDVLQAGARMSLAHGVGQRGSGNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C458</accession>
    <name>A0ABR3C458_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_100220</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 11">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616693.1">
        <property type="nucleotide sequence ID" value="XM_066754792.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987078"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0255416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="123" mass="14161" checksum="F66628DB4D0E6976" modified="2025-10-08" version="1">MPTLKFCGECNNLLYPKSDNNAKVLLYQCRNCNYTENATVEPGMAGCVYKHDLLTVAREQPGETKDLDTDPTLQRSDIECPACHHHGAVFFQDQGRRITTNMTLFYYCTNCKHLFRDPTVRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C482</accession>
    <name>A0ABR3C482_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">L-lactate dehydrogenase (Cytochrome)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100241</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616714.1">
        <property type="nucleotide sequence ID" value="XM_066754813.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987099"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="108"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="54760" checksum="AC628139232FFEEF" modified="2025-10-08" version="1">MSQHVDGKQVAEHNSREKGVWIVVHGNVYDVSDFLDEHPGGADIILKYAGKDATEEYDPIHPPDAIKENLDPSKHLGPLIPSTLPVEEPAPAPAPPPTSVPVGQTTNQNGASAIEEEGGIIIALVRMMKLLWYVQKAISKLLTKKRENHNAYHRVWFRPRILRNVGTVDYSTEILGFKTSMPVYITATALGKLGHPEGEVCLTKAAGEHNIIQMIPTLASCGFDEMVDAAIPGQVQFLQLYVNADRERTKKIIRHAAERGIKALFITVDAPQLGRREKDMRTKFEGVASAQQAKGGDKYQRDQGAARAISSFIDPSLNWSDLKELVDAARGLKIILKGVQCWEDAVMAAEAGVDGVVLSNHGGRQLDFAPSPLALLPSVVKHLTAHGFMNNPLRPRFEIFVDGGVRRATDVLKAVALGATAVGIGRPMIYAMSTYGKEGVSHALQILKDEFEMNMRLLGAPTMADVVPNMVDTSGLFGPQGSVTMYEENYERMLPVGVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4I5</accession>
    <name>A0ABR3C4I5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA phosphorothioation-dependent restriction protein DptG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616825.1">
        <property type="nucleotide sequence ID" value="XM_066754924.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987211"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="792" mass="90298" checksum="08863E65F54A2784" modified="2025-10-08" version="1">MPFRARCNPANLLQRRHAVLALRKARTPLLSSAQLIQEPIRNDVMHHIRLSSTASLLSPFTSFFSRVRKSQTPEAAAEDFANALETRSLEVMSKAYGAVVNDPIPSNLLSEEQLLNAMKALAECTAKIPKAIRLLQRIYEDFPTRFGYPVRQGHKQIVLQGLVNCGMVREALEIALSMDQKDVNWRLMLRAAVDADVALSDIIVQHFRQTTPPDQEDYILLLRIIRSHPSQDKMRLDWLLAEMEQKGIIVDQNIQAEVMQVYIAFGELEKAKQIMKKWDFFALEDIGPRMWDAQVQYFIAVHDFSKLSTAVLSMRDAGYTVQQDAILALTLEQLNQFIDSKSKVSYSDVIVAIHAAEQMTGTEPGSKVWAKVIRHYLQNVKYREALEVAVRLYEECQGRGVALDVELARTLIIPLCSSRKQNRLDDALRIYDQYMSLASSAELESENTRLRFAEVYEKLLVACARTQPPPMASVIRLLDDMRTLSLDFTPTNLISLLILLMRASPDHVSAYNVYSHFHALNPNAIDQAGFSAILTTFLNLSWKHSPLTPPDLFISMMKDMNRAGYSPSPYILSSLLKQYGQLATRARRGNSVESEESIRGIAKAIRDVHTLIKLDPLISPDIPLLTALMDAYGRVGAFFEAFEVWDELVQRRAREPRQTVQEVYGAAINVMLDTCGWSYSLGKARKSWGWARRWDLVWEKKQWDGWIECLCRCGEVEEAGHVVLDEMGTEAIPPPDKETVRLLYKFGRKQREKGRNVAGIDRLMVRVRERWPQWVEELSNERGLTKMSKRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4P4</accession>
    <name>A0ABR3C4P4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616875.1">
        <property type="nucleotide sequence ID" value="XM_066754974.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987261"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="274" mass="29968" checksum="852F5A9C7127DA47" modified="2025-10-08" version="1">MSFKDSASNSPFLYPFDPASPLFVLKGILATGTFGAVTGASIGALQSKNPYTLGTNMAINMSIAGLAFFTVREYLVSPFLLIIEATPSHSRRLMEIQLSEKQRSKLPQVTSVGQVRTDRLLDSALAGALTGGILSATFRGRATFGKAAFTSALITSALQLSANQLRVMRLNYLAKSQTRISSLDTVAPSEQEPTATFDALKSSIPSPEPTSPPSLPERMMSSLTKVLPVRKLSNEEYLATLEKKRAEVDKRLKEIAEEEMRMYEWAQKQQQQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4W5</accession>
    <name>A0ABR3C4W5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_100475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616945.1">
        <property type="nucleotide sequence ID" value="XM_066755044.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987333"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="384"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="555"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0255668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="706" mass="78245" checksum="0871EDA7EC8FF562" modified="2025-10-08" version="1">MCGIFSYCSFLCERNRKYVCDVLCNGLARLEYRGYDSAGIGIDGDSKGSPMILFKEVGKVAALRKHISEGIPCPLPDQAPLKEKVDMSKLFLSQTSMAHTRWATHGVPSPGNCHPHVSDVQTEFSLVHNGIITNYKELKLVLLKRGYAFHSDTDTEVVAVLCKYVWDSQPNKRLNFTELIKTVVKELEGSFAFVFKSTHFPDEIVAARRGSPLLIGVKTDRKLKVDFVDVELPTAEERVNDVDASGLLAVPAAVAEGPGPKLRRSQSRAFLSEDGMPQPIEFFVASDASAVIEHTKRVLYLEDDDIAHIAEGELHIHRLRRDDTISSVRAIEHLEIELAAIMKGQYDHFMQKEIYEQPESVVNTMRGRVNFDTRSIMLGGLKAYLPVIRRGRRLIFVACGTSYHSCIAVRPVFEELTDIPVAVELASDFLDRRTPVFRDDVAIFVSQSGETADTILAMRYCLERGALCLGVVNAVGSTLSRETHSGVHINAGPEIGVASTKAYTSQYVALVMIAVQLSDDSITKTARRQQIIDGLHDIPAQIRKVLAMDKVLQQMAKDMLSKEKSLLIMGRGYQYATCLEGALKIKEVSYMHSEGILAGELKHGPLALVDEYLPVIFIMTRDSLYPKVQSALAQVTARKGRPIIICNEDDDTVSDNAKVIRVPQTVDCLQGLINVIPLQLLSYHLAVMNGVDVDFPRNLAKSVTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C556</accession>
    <name>A0ABR3C556_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA-processing protein EBP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617019.1">
        <property type="nucleotide sequence ID" value="XM_066755118.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987407"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44269" checksum="E49AB5BFA9413F0B" modified="2025-10-08" version="1">MPISKKDARKLKSNKKLDSPKTENSQSLDKQSYAADEQIESGDEDDQDVSEEGMKRLMELVDVDDLNEYEMALLGAEQDEEDEEEDSEEEEVEMSASQSVDEDEEMQGEDKEQDNTIVNEKPDDDVVSLDGLGSDVSVDEDAVPMQKVTINNKPALRALTDSIRVTSMPWPEHLVLNSKETADVDPSDDLQRETVFYKIALGCIPQARKLASKHDILFTRPGDYYAEMVKSDEHMERVRTKLVEEAQGIKKSEDAKKQRELKKFGKQIQHEKLRQREQDKKSFENRVEGLKRKRKEGMELGDEGDEFEIAVEDAVEDQPQKGGRTASGKSKMPRHARDAKFSLGGGGRRSKQNTRESTMDFGGGMSRGKGGKAGTAGKAKPKGRPGKSRRRGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5K7</accession>
    <name>A0ABR3C5K7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Membrane magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100421</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616893.1">
        <property type="nucleotide sequence ID" value="XM_066754992.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987279"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF7">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045594986" description="Membrane magnesium transporter" evidence="9">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11683" checksum="7784CBB5956430E6" modified="2025-10-08" version="1">MSKLIGKLLVCLACLTLFHAAFSTYEHLSILKTLSRPESGVPPSIVTEAFVSLICFTVGIVYTAGELKDVTYRGELAHRTIDDSDARMGFMRLSKRGKAIFGDLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5R2</accession>
    <name>A0ABR3C5R2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617235.1">
        <property type="nucleotide sequence ID" value="XM_066755334.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987627"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="34607" checksum="AC4C906DC1506B52" modified="2025-10-08" version="1">MIHAMPNVQEDLQRDNLGDPSYDEAIQLAMDKRQPEYIGDLMERALNFPELKCFGNILLSHVVHRLYPEHATSDDITASQRDMISIVDDKVFWHNTLRLFHTKYNIERSYDVINPNLKPIDVMLQGPVDDDQPFLFARVMRIFHFDIYKKRKAGLVTVNVVEKHSLPVIWVRWYETDGDWRNPLDANHMCQLKWMEGPDAYGFVDPTCILQACHLIPCFKNGTHQSTDGLQSWESFYLSAFVNPDIMMRFLGGGVGHQQKGRENETLSSVAQADPQNSSTGEVDMINVNAGADHNGSDYHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5V2</accession>
    <name>A0ABR3C5V2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617281.1">
        <property type="nucleotide sequence ID" value="XM_066755380.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987673"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="57"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0256004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="519" mass="57709" checksum="7E88A2DF2731DF1F" modified="2025-10-08" version="1">MVRPVSSLVSLADALHIKRNRSSASLTAPSEVTLVRPPQSSLNLHHTANTHPKDIDEHLPTQVLIHILTFCSPATLSRCLSVSRLFFHLAGDLLYSHISLTPKDFSRVFRGSAVVHEALTGKVAVGRKKFKDRLLKHTRQVTLYSHGDDEDEDQVLNCNACPPTPLSIVMPRLDTLRVVLADAFDYHMTFCPRYPHHCPLLKELNIEKLVILGARTPLVVLPLAFPNKTTSQQTTPAGLERVPSYLSVDTLEGAPSVISSISTTPSSHGHHSTFSSFIPHRNHSRNSSLNVSLASASNQTNQGGRTPPRAQSPGNVHHSPRLPPLRELTIVMPTGLSYDAKDYQPHSHCFRHKRTLASIERVSIVFYTPSPPLSGTGKKSRGKGQTQQIQTQRPWQTAFYQGGNYNSMTSYISLADDIAETVLSLPSITEIFIIGCETLDGDLFNMGMNAMQGGKNKVGRLMREKICGRVEARWWANREKGDVGKVVEKMRFLELEEWLEGDGREDVDGWDLDKWAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5Z9</accession>
    <name>A0ABR3C5Z9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617323.1">
        <property type="nucleotide sequence ID" value="XM_066755422.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987717"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0256046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="80" mass="9142" checksum="092D4B1358A7FF86" modified="2025-10-08" version="1">MLDVIDDIKGRSTYEEVYNDPHVTVVNVGTPHVLHHCNAKDALLTGEHVLLEKPVWLEVEVLDELIKIAKEMSRFFMEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6F4</accession>
    <name>A0ABR3C6F4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616628.1">
        <property type="nucleotide sequence ID" value="XM_066754727.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987009"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="560"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="591" mass="63633" checksum="AE94FB776B7174A3" modified="2025-10-08" version="1">MPALHQWDYLFAFGVLFAALDAYNIGANDVANSFATSISSRSLTLRQATVLAAICEFLGGVLAGSRVAGTIKNGIISLSTFKNNAGVELLAFVCALTASATWLMIATRKGWPVSTTYSIVSALAGVGVALDGPGAVNWGWNNGKGIATIFAGFGIAPGISAGFGATVYLITKYAVLKRKNSLKAGLIMSPIYFFTVAAILTMSIVYKGAPQLKLNKLPQTTIALAIVLTGVVIACLSAIFWLPYVYSKVIKKDYTIRWYHFFYGPLLWRRAAPPPPPEGVRHVPDYRIYDRDDEHEQPATQTRANPVSEDSTEGEGAPLEANVTATSQEKDKDIESAPSPSLPKGKPYVSALEDLEKDDHKIEGAIILPRNLWILFRYKLPKLLLHGTSVDIHAMQSHKGKGKEGDRMMKMYEHAAQYDNETEHLYSFLQVMTACTNSFAHGSNDLANAVGPFAAIYYVWSTGMVTPANTVTPVWIFVAGALMLVLGLATYGYNIMAVLGNRLTMHSPSRGFSMELGSSITVLLASQYGIPVSTTMCITGSTAGVGLVSGGIKSLNWRAFAWIFLGWVLTVPIAGTAAGCLAGILINAPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6H5</accession>
    <name>A0ABR3C6H5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular mutant protein 11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617027.1">
        <property type="nucleotide sequence ID" value="XM_066755126.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987415"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="55650" checksum="C0589E52D425EFC2" modified="2025-10-08" version="1">MSKLAVTPINKATGLMRRHPSIRAPDRSSFGSIPEGVKVELHYLPPPAFIVDHSPPTCHSANTPRKPDREGARISPFPDEESFQTFENARAAVQDDDPFGGRHRKLSKSKGPSTTSPVTLGRSDFFGPWEPVKPQPSNHHLQDYRHSPASEPRDPQPLQQPKSFSIGNMPPPSDIIQQKGARSHLFNNGHINQQPVIQARSGGPCISQHGRGVLQAHPQITGPTNGFVDGPPEIVAEPSQYMSMDPGALDKPSNITASQQRGQELNSHYDKHFQTPAANRHQVEVNINHPDHRGCSNAAGTHGHILRQEMSHDDEFSKGSLQALIFDDDSSMIDFDGTEQILERTPDKRRAMDNGSESIFNFTPRAEGHPNLSKNRGCRFVIPKDFSNHLTILKEIDPQAILFKRMKTAQVLDHGGKWTDPKQIVQDQVSQFDSIKRRWEGFFGRLEDLVQTKDAVLQHKRDLTKQYADAGEQLAEQCDEIQLATCHIHKKKRIWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C871</accession>
    <name>A0ABR3C871_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616946.1">
        <property type="nucleotide sequence ID" value="XM_066755045.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987334"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="111"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="567" mass="62051" checksum="E9C67F97C65FC0E6" modified="2025-10-08" version="1">MRPPDQLPVILNNNNHGLLAIQRSTLDVLQLSSDGRPPKRLVTCPLRNFLKAYLAPAPENSARRLDLHFLGGSKGSQMKLVKLHVLVEPINIPETDEWTRSLMEAAYGLIKPFRNVLILVNPVGGKGKAKNIVQDTVIPILDAAGATVTVKGTTHRLHAEEIARSMDLVYDVIATASGDGLVYEVVNGLASRPDARKALLTPIAPIPTGSANAVCTNLFGVKDTFNIHLATLNIIKGCRLPIDLCSILILPSMTRRFAFLSQAIGLMVDLDIGTENLRWMGDTRFLVGFLKGIANNRGAFCRLRLKVVEDDKQDMARKAKERIQQGTIDGGDVAPLTNQMKNMSVDGDTPVSANDDIPAGHGPPTVIEEPTSSASLPIPMSANANYVPDHGPIPDAQLLKYDETWITIESLPKKSSIKPKNSTQSLKAPSKASTQNKWVDGQGILYVYAGMMPWVARDLMQWPVSIPGDGLIDVVVQSVVPRLTMANAIAGAEKGETYWMDCQYYYKVSQFIAENLDIENQPLFTIDGEAFPFESFHVEVHTRVANLLSLNGDFFTSDFLKKPNGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C8D6</accession>
    <name>A0ABR3C8D6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617006.1">
        <property type="nucleotide sequence ID" value="XM_066755105.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987394"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="366" mass="37711" checksum="069DBEFC36F025C9" modified="2025-10-08" version="1">MIRRRLSSGLLRAVSSSFPSPAAPPARTLASAVLLTSQTNWKMETVVTLKAELKKRGLSQQGNKATLVSRLESAETSSLLPPVPPIPSSARSISSTASLSRSGKLSDAPETVIPSGNAEVNSDVAPGVSVTGPGPQVISQRTSAVNPDQVTPEQVTVAPGLPESKVFSESAGETLDVRMPGPRAEEDIDQVIPLIPDNFSAQSYPSSASTDPKVLTVASASTHPAGGPVHASHDHSDAHSLELATEAASSSLPSLESIATSMFSVPVAAWTALGLQIPKVGLPQGGSGEYKYNSRELNHDERAGVWILAGLIGAGLFLGGPKKDKTSAAAAHEESHAETQGKRVVGDAKWAQASGAGVVGHGARKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHM2</accession>
    <name>A0ABR3BHM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610715.1">
        <property type="nucleotide sequence ID" value="XM_066761175.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993609"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45093:SF2">
        <property type="entry name" value="LISH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45093">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR MSS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="870"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="911"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1145"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1231"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="451"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="522"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="695"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="745"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="873"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="926"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="956"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="998"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1043"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1077"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1093"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1145"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1173"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1236"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1301" mass="141931" checksum="9DA4D79A6B5CFE90" modified="2025-10-08" version="1">MALPHPPQASFHGQPQPPYHIQQNQMMPQHMQQQQVQQAAQIQAQAQQQQSQNPQQFHQQYGMARPVGMNSLALNQQQQHALQQAQARQQQIVQAQAQAQAQAQAQAQAQAQARAAQSGQQQANQRVVPSSLHHPSPSPHMGHQFPPDLTYSHPLQQAPGKHVSQMSPGSARAVSGLPQAVQVDNAAHPKNITGGSGWMQNAMVGPSQHPGQPSQNPQESQSQQPQPISHQHHLQPSHLPHSTPTPQPQPPPQILGQPQGPGPGAILGHSPAMHGPGQRMAQQMGHTQQMEQAEYGIGMSMGATMSRGANSSQEPVRWDADHALKAYVHDYLMKHGFPGTAAQFSVEAGLNDGGIPVNAREGVLYEWWNIFLELFSVGRGVQAVIQPSYYTECMTRMRSLRQHQMINNVTYTPQNVQTAASQPPQPPFTSQQIMALRQQAQAMGLSPQQANQYVQQQVQQIQQQHQQQQEQQHQQQQQQQQQQQQQQQQQQQLQQQQQQQQQQQQQQQQQQQQQQQQPQQQQQQQPQHQQQQQHSQQQQQHPQQQQQHPQQQHQQQQQQQQHAMMQQQQQQRFQFAPTSSPATSGRPVSRQGQQGQPTMYQPQPQMVLQPPAVVRTSSHSPINPSPHMVQQPHPGVMSSPSQHMRPPISGLMANGQMRIPSSGPPPGTIRGQSQPQPQGHAQGYVDSSQISTTVPSPAQGHQAHPHQPQPGQTQHSHQQMQHSNPQHMPQPQHPHMTPTQQQQHILQNQSANVQTAQQRAQQSLAEMHAQVHVQAQAQQQQQLLQAQQQAQAQAQAAQQREQAIQAQQQHIQAVNSQMWEGLGLGHVNHGVMSYSAQSLGLGGKDPQSMGEEEKQRLIHTYKLTLQENQRRAMMGAQQSQQQTPQIQHQGQGGPGQLHQNQNQQYMMMPHQQSMHPQGHPGMRPNGTVTRNQPYEFSQQPQPQEETKASSTPGSLNQSTNNPTSASQSASTPTTSTANKPSPPERKRKRKNSEKENKPSSPFGMAQFGQGQPGQGLGQGRQGPNAGAAGPVTPGLNVTNDPMRPIPGTAPPPPVSASPRNPTKRERRNQAKEMLPPRTTTPKPATSGNAIAENDARETKERKETSGRGGKVNRTPKMPKEELLREVPTPKSLNLSPNGNVINVTDANPNSTSTHGFTPSPPSASTSTPANGALSLSSTTPASGQLSLPNDLSMSHMDFGMGLSSMGLGGMGMEFAMGMGLGALGGINDNNRQGMGNDNGGAGGNNGLEGSQGGDANAGTDLDALAGIGQDFDFGLYLATLDEEGDNGGSNGGNGGNGEVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIB6</accession>
    <name>A0ABR3BIB6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610943.1">
        <property type="nucleotide sequence ID" value="XM_066761118.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993551"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="382" mass="40578" checksum="B9DB7F6CD421E6EA" modified="2025-10-08" version="1">MSHELSPLFDLENSPASPLSPSLASSPSLPSSKLKRLSLVAKPRTLSLYIEREIPVSTASVKNMIPPHISSTSTGNRRQIRHSVTGSPAGITYSPSPVGTGGSTSASSMDMRNGENLHPSRGAYSQSIYGSSIGFRQEGVEASRERIGESEESQTLDPQTFMDRHADFLRLIAQKERRVHELREELQQQESSLESLKVQWSSLVSLAAPSSQPSTSISPSPSEYATHLRAPRARGSLASPTLTSFSTSELSTSSSSSPATIGGPPSRLRHPPSCSSHILTQPNPSADVNGGGLERALSGIITHTEEYLGPEVVQGGIKFLGNLWKTVGAAAGGTVPLSSIAEREGATRGREENGIRLGQVLICPVRESAVAPWKSSKSPGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIG3</accession>
    <name>A0ABR3BIG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610988.1">
        <property type="nucleotide sequence ID" value="XM_066760716.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993138"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="120" mass="14256" checksum="35FC3A7A72D54B42" modified="2025-10-08" version="1">MNIILSEAVDFFSEKVENYGNRDSGRWFMYNVVSWRGDLWDPIKSYESLDIRLHNEVWSQDIRQGTCTCPAFERSPFLFCKHLYAIYRPTDWVKFVHSATRLRPPPFWSSRELKLADGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIG5</accession>
    <name>A0ABR3BIG5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610986.1">
        <property type="nucleotide sequence ID" value="XM_066760714.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993136"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="88328" checksum="C1E87FD5B4C743BD" modified="2025-10-08" version="1">MTSFPGPLPSQRISSVAPHSDTSPSLRTPRLTRYRSDTMLSTSSSTSSILQTPETPSILETLSAGLGPGIHIGPPKSQVDSPNGLRIRRRASSYEFGALWEESPGDHQAAKAGPSRLSVTDREWRLCDSPEEHDRDDYFSPAANMAPANFITYQPSTLPQKTQTEPEVPQIADPGITTTNPARPSTTRRMSSKLKDVVRLKLGRSKSSFKVLNRKTQHEEDEQASQSPYISSSNPSTTSRRQRLKSLISFSQSSNFSSLSLLARKCLGGIFECRVERAIGEACNEKIDPIEEELDRKGKGRAVHLPHPSLVQSQTPDFHNPVYDLSTPPLTQKLSFPLDPLCTEEAEEVKHVSFEESLPKELKLLVMKKLMESFANESFGRLSGELLGRMELIKMSTVSKSWEALCFDGQLWPTIDLAAVAHLLPVSIFHRILRHSASFISNLSLRGMDDIKGEMLIKALGGDNVDIMRYDYINRGPRLNVQRLDLSWCDTLTENDLASIIACCPNLRSLSLRGLSVVGSKLMYFLEKMETLEEIDISYCRALELPMLSSYIKRFSKVQADKLRSIRAAGLHYPSDMLLLSIMERCHNLERLNLQGCHDIGYARASSGAIVDLIKGCKKLRVLELDNTEANNSVMREFLRRRAYPCSRLSIIDCHNITQSAYAEIAASTRARQGWKGWAAVPFGYDNDVEMAERMVLKTFWGWKRVVVPKGWTEMRNEAEKMESRKRARLEQDACGSVGENSNGSKWKGDGKANAVDGECLVDFPFCSCKTHTSTDIYTYNCLAAMLTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIJ0</accession>
    <name>A0ABR3BIJ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611007.1">
        <property type="nucleotide sequence ID" value="XM_066760735.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993157"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF2">
        <property type="entry name" value="VHS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="392"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
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            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
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            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="222"/>
            <end position="234"/>
        </location>
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            <end position="248"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        <location>
            <begin position="1026"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1085" mass="118437" checksum="1492590B16BF13CA" modified="2025-10-08" version="1">MKRIFRSTKSPIDPLPPPQQPSNISNPSSGRSTPHHQGARSITALFGGGDSNDNSPGHEHKWGFSLHHHSEVTPFPAEVGADAVPPPGSAKRKDKSITAPSLLEIKQMQEKRSQAEEARRRAPSQPIPPPLQQTERLSKAYQSSPSPDEWQSVPSQTQNQNGGYDTYAQPLPVPNASFSQSPTNSNSSTASGSAHNTIFLPPGARPPTPPSARPPYPLHMRYSQSNLHNSTTPGNEEEAAVKSGRERGYSSPASAVAVAPQSDQNHSSKLTKATRSPLSHAYATVDLPDPPTFPSPKPYTPGISTPTPNNYSRRGSSPVEGLPNPFSPIENIPIGPNSEVHTIPNQRDEHPPELKEKKRFWGMGIRSDKKSKAKAQAEREHAVGHGQMQVIPQGDWRPSVDGSRGSIDAWRDSESRSTSVHGHPVQFEEEPRGRLLGLDFGRKDHTATQVNDVTSAIQMLAASSDPSSVAIYEVCDRINHSDSSESVSKEAARALRKEFKHGNELERRNAAKLWLLLMRNVTVKGFRPYGSNKKFFQSLEPILFAPSSKPIVSPSTHRLLTDVIADLTFSYGMEKGCEMLVDVWKKVKLSQESDYGHPLSADHPIFNTNELPSQPQPPTTQIANLQIQSPPSISTSWHGSSPSHVHQALSPPPAPVRHVQQQPAYGGPGYANLPSHGEDIRRLMEECTAAKESARLLGDALVYTRPEELDHKPVIREFYTKVFHAHESLTNQMDWAQAEASRSRERHANLTLDGSVPNNTNVSSETTPEERALAALFEAHAMLAEVMKQHDQLERMAHDEKELRVVRERSKKETKMDRSHLAATPINQTSASRSPSPTPHGLPPATVPQSNNPFRRQAQDAFRSRTPSPDRHAFPHITRLSASPGRASSPLGPGPGSNNSHSHVGAGNTGNNIANNKLRMGGPRPLPNPFKTIAGGANDSQGSLSTQADTAPSRSGTGDSNRSQAVSINGSAMQSAVMNEEEVDGDELPRVPIKPSRKALGKRRAVIDEDNDFDPNDLFNPQPTDPRSRESHSNDDTSSDESMTTAAVFNAKPVAYAYDAYEERQKELKRLKEEEERGVVGGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIN8</accession>
    <name>A0ABR3BIN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Solute carrier family 25 (Mitochondrial citrate transporter), member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106357</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611060.1">
        <property type="nucleotide sequence ID" value="XM_066760788.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993212"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
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            <begin position="109"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="206"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0240561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="31957" checksum="8547731B251E2D0E" modified="2025-10-08" version="1">MSAQARGKAKEKPIASLLAGATAGGVEAFITFPLESIKTQLQFGALDGGKPLTPYQALKSTVQQRGIHGLYAGCTAVVIGNAVKAGVRFTTYDQFKSLLKDDEGKLTAPRSMLAGLGAGMSEAIIAVTPSETIKTKMIEDSKLAQPRYNGLVHGVQTIIKEEGYRGVYRGVGPVMLRQGANSAVRFSSYSTLKQLAQGSAVPGEDMPGWMTFGIGATAGVITVYSTMPFDVVKTRMQSIHAKQEYRNAFHCAFRIFKEEGVFKFWKGTVPRLGRLVMSGGIIFTVYEKTYPLVAAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIX2</accession>
    <name>A0ABR3BIX2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IMS import disulfide relay-system CHCH-CHCH-like Cx9C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611137.1">
        <property type="nucleotide sequence ID" value="XM_066760865.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993291"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052848">
        <property type="entry name" value="CHCH_domain-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031731">
        <property type="entry name" value="CX9C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47106">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47106:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16860">
        <property type="entry name" value="CX9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMS import disulfide relay-system CHCH-CHCH-like Cx9C" evidence="1">
        <location>
            <begin position="7"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="115" mass="12606" checksum="C1FA4AD3620D9AB4" modified="2025-10-08" version="1">MDLSYNVVAANCATQMAKYQECVLKNQAGDWNQICRPEGRALAACADASVPHLAELKASCAEQIATYRQCLEKHASQPDEVISENCGGLMKTLWECTEKTVASIEKREAGEKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ17</accession>
    <name>A0ABR3BJ17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-oxoadipate dioxygenase/decarboxylase</fullName>
            <ecNumber evidence="6">1.13.11.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-hydroxyglutarate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_106480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2-oxoadipate dioxygenase/decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.93" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611180.1">
        <property type="nucleotide sequence ID" value="XM_066760908.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993335"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16348">
        <property type="entry name" value="VOC_YdcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.80">
        <property type="entry name" value="Uncharacterised protein PF07063, DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009770">
        <property type="entry name" value="HGLS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047869">
        <property type="entry name" value="YdcJ_bac-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479:SF2">
        <property type="entry name" value="2-OXOADIPATE DIOXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07063">
        <property type="entry name" value="HGLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01150">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0240681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="456" mass="51272" checksum="70BB3AB10CBA0A1B" modified="2025-10-08" version="1">MTLTQSKFVDPNELRAAFCSALSDMYRQEVPLYGDLVSLVDEVNSKVTTASPGLWEVGDRLRVERHGAIRLGKPSELAMIARFFRQLGMSPVGYYNLSTSGVPVHATAFRPVTPESLEIHPFRVFTSLLRPELIIDKQLRAEVEEILEARDIFHPAVKALVAKAEEQGGVLPEEAKELVEKALETFKWHERALVTHDVYERMKRMHPLLADIAGFRGPHINHLTPRVLDIDMVQRMMSERGIPPKRTIEGPPKRICPILLRQTSFQALTEPILFAGASPGATSNGKHRARFGEIESRGCALTPKGHELYQQLMSQVGSLTPTDDNDKWQARLSSIFIAFPDSWEVLRSEKLAYFKYKVAPLPFSPVEPKSLEQLIQAGVVTFVPIVYEDFLPASAAGIFQSNLGEHEKQTVEGKGEAKGELEEYVGGKIWDYFALYEKMEKESLEEVKRLTSCTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJG4</accession>
    <name>A0ABR3BJG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">26S protease regulatory subunit 6A-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611316.1">
        <property type="nucleotide sequence ID" value="XM_066760555.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992963"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="250"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0241934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="469" mass="52408" checksum="AAC8130B8A9FAA71" modified="2025-10-08" version="1">MSAPAQDPPPPPNPTDGDSIKPQESSDAPQQTTQENESAEQQQQQQEEVEQPKPKEDTFEDVPEHVAKSDVQEIKMQTRMIDNEIKMMRQENLRLSHEREQMVEKIADNTTKIKQNKVLPYLVSKVVEILDVDSEEQEGATHNEQNAKKSKCAVIKTSTRQTVFLPIIGLVPHNQLAPGDLIGVNKDSYLVLDKLPDEYDARVKAMEVDERPTETYTDIGGLDKQIEELVEAIVLPMQQADKFKTLGITPPKGCLMYGPPGTGKTLLARACAAQTNACYLKLAGPALVQMYLGDGAKLVRDAFELAKQKAPAIIFIDELDAIGTKRFDSDKSGDREVQRTMLELLNQLDGFSSDSRIKVIAATNRIDILDPALLRSGRLDRKIEFPLPNESAREHILQIHSRKLHHHGVNFEELARSTEDMNGAQLKAVCVEAGMLALRQNATQLTHEHFHGGILEVQARKAKEHHYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJH2</accession>
    <name>A0ABR3BJH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_106039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611249.1">
        <property type="nucleotide sequence ID" value="XM_066760488.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992894"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0241867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="514" mass="56566" checksum="C37A32DCD72B8EF1" modified="2025-10-08" version="1">MSDAFSTPADHVLSHPELEEILENAQAGPSSMGDGAEGLSIEEAFEVDETVRRVLEGGYKTIGLQFPDELLPSSVSVYRAIQTRVGHTGAQAYVLADSTYGNCCPDVLSCLHLPADFLVHYGHACLTPTDALPVHYVFPRQKLDVKQAVRSLLRASKDELGDEGKKGIVVVWDVSYDWLAGDIRDTFSQDLSVPISFAFIQKPVVAPQKVLKDGKGKTPALRSVEPPQGLEMNDCVLWYIGEEGRSCMNLQMTHANNPLFIYSPSSQSVSPLHRSTSRLLSRRLFALHQALSADVFGLIVSNIGLASSKPLLARLREDLKRAKKKSYTLSVGRLNPAKLANFAEIECFVLVGCAEGGVVDSKDFLRPIITPWELELALQGPEHVWVPEKWTLDLDTVLKDAQEREAQNEQDPSTTDSDDDSPEFSLITGTLRTKKRFATGNGGQASDNTNLLEDRVRDLTLRNQNFSLSKLESAGSTFLASREFQGLQPRYGMDEPSVLEQGRSGVARGYTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKA6</accession>
    <name>A0ABR3BKA6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_106023</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611233.1">
        <property type="nucleotide sequence ID" value="XM_066760472.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992878"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="152"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0241851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="337" mass="36829" checksum="4C0DAB00F497254E" modified="2025-10-08" version="1">MTDIPGAKRHKPNTSEPLAVGSALKKKQPKMPGPDYEKGLEYWDNVEASVDGVLGGFGTGPVPHIEQLTSRLLLLSLIPSLSPFSNPLCPSPIAHPSLPAHRRVALDVGAGIGRVTRHALIPLFDDVILVEPVGKFVSEAYRSAAAGEWRDLPSLEPLPPKPSTSAEEDKPALEQWKEAKRRQDESKSGRGKRVRFVKGGLQFLDPKSPGKGGEELGIVGEKRGGEGGLDGENVLYDVIWCQWCLGHMNHADLVAFLRRAHAALREDDEDRQSYIFVKENCCDDGPGGIPQEFMDEEDSSLTRSSAKWLQVFADAGLKVIKEVTQEGMPEELFVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKG4</accession>
    <name>A0ABR3BKG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611667.1">
        <property type="nucleotide sequence ID" value="XM_066760363.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992769"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0242285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="247" mass="27309" checksum="095299BEB047746C" modified="2025-10-08" version="1">MLIRIPSVPLHMFHMAHGGSSTPPYTMSASVHSPFTFALIDSTLSKKENFEGLRVSFGIDQENGKLGMEKKGIPQADSEKSIESSFTPQAQNFSVSLITMNGNMNTPMEIGNLSSLVQSTDASAESSVVLKTPPTSVRAGYSLVEHITTALSTWQSKGCCHRFDNNQMRQSFEPDPRIFGICQQGSHHDEPKMLNGMSEATLEIMVRAGKRDLRAGKVQETWMEHTMAKTKHGNGMVNIAEKPLFYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKS4</accession>
    <name>A0ABR3BKS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Malate synthase</fullName>
            <ecNumber evidence="2 7">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105991</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 7"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611744.1">
        <property type="nucleotide sequence ID" value="XM_066760440.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992846"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="8">
        <location>
            <begin position="158"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="10">
        <location>
            <begin position="408"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0242362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="538" mass="59923" checksum="5193556DAE1D3A23" modified="2025-10-08" version="1">MSLPQGIYLTAPIPKGGEHILSTQALEFLAVLHRTFNKRRLELLKNREKVQAELDQGKSLSFLPETREIRENLAWSCAPPGPGLEDRRVEITGPTDRKMVVNALNSGAKTFMADFEDSNSPTWSNMVLGQVNLYDAIRRQIDFEINGKAYKLSEKPAVLLVRPRGWHLPEPRLIIDGTPMSGSLFDFGLYFFHNAPELISRGSGPYFYLPKMEHHLEARLWNDAFSLATSHLGVQQGVIRATVLIETLPAAFQMEEILYELKEHSAGLNCGRWDYIFSFIKKQRAHKNCVFPDRSDVTMTVPFMDAYVRLLIQTCHKRKVAAMGGMSAQIPIKNDPAANERAMSKVRADKLREVTAGHDGTWVAHPALIPIALEIFNQHMPGPNQYHVRREDVTVTDKQIADPSVPGKITEQGLRDNVSAALSYCAAWISGNGCVPINHLMEDAATAEIARVQLWQWCKYGSKTDSGKDINPSYVQTILSEEASKVSKLPGIDPSHVKIASEYMAQQVKADWPSDFLTSDLLGYLEGVGTKGGAKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL74</accession>
    <name>A0ABR3BL74_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611912.1">
        <property type="nucleotide sequence ID" value="XM_066759966.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992366"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF45">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="312" mass="35059" checksum="F30695B357885B20" modified="2025-10-08" version="1">MASLPASLEHSLPPLKPESLQCIYRLLSYSSPEIKRRLPLRRCAAVAVILFVGRLGDLYVLLSTRAGNMRTFAHDTALPGGKYELGDIDPEGTARREAYEEIGLPIDRNKVRKLCILDPFLTGNSLIVTPVILLITDYTLTPLLNPAEVSLLFSMPLASFLHSRPSKIPSFQYRIFHRLALIPPGTIESIPPPPPIAYAEDEGQVSWKEGKFYGYRDVKWGEGMVRMHRFLTGRESNGVKPVYGLTAAILIKTATVAYNRCPDFAVMAPGQKSMEERIEFEIRHVQSPLRRALEAEELCDERREDKDVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL98</accession>
    <name>A0ABR3BL98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611025.1">
        <property type="nucleotide sequence ID" value="XM_066760753.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993175"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046579879" description="Integral membrane protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="46907" checksum="194A2726DC74A57F" modified="2025-10-08" version="1">MPNKMGVSTLVAGMFLTGCANSLLSKYQDMECVENCGKHAEGPQVNFEQPVWQTLNMFIGEFMCGLPLLWAYYKKRKAMKTRPEGYSRVATAENEEEHHLLGHHHDHGQLLSGWRMCWLWFPAFFDICGTTLMNVGLILTPVSIFQMSRGALVLWVAVLSVIFLRRHLWLYQWASLIIVTFGVCLVGLSGSLAKEALSDPAELLVTVAARPADDPARAAVGVMVILFAQIFTAGQYVVEEKIMSRYTVEPLKAVTLEGFFGLITTLIAMPFLHLFLRHQSPYFDIPRGWHQIISTPTVLWSCFAIMLSIGSFNFFGLSVTHSVSATTRSTVDTCRTLGIWIVSLGLGWEALVWPVSFLQIIGFALLVYGTFVFNGLVKPLIFPPPPSVHLPHEPELEETGEVPAAGAQGRSGYDVIPEEENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLD9</accession>
    <name>A0ABR3BLD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_106521</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610773.1">
        <property type="nucleotide sequence ID" value="XM_066760948.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993376"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="59"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="434"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="696"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="177"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0240274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="750" mass="83995" checksum="9069B0D728CD3E83" modified="2025-10-08" version="1">MGRPRGKKHGGRGGGRAPQTRDNGAGEWKVFSPADYKNEAFEAYYKEQNIMTPEEWPAFMSSLKQELPLTFRVTGSRAHAETINDIIKDTFVPNMQNVEFEGKKYDPPAQLAWYPGQLAWQVNAPKRVVRKTEPFKNFQRFLVGETEVGNLSRQEAVSMIPPLFLDVQPHHYCLDMCAAPGSKTAQIIEALNPHHTTSTGLLIANDSDYKRTHMLVHQTGRMPSKGLMVTNFDASMFPAIKLQDGKNLQFDRILADVPCSGDGTLRKNIEIWAKWGVTDGNSLHSLQLRILERAMNMLKPGGRLVYSTCSLNPSEDESVIAAALLKHTQFSLVDVSSELPELKRRPGMAKWKVATQEGKDGEIHWYNTFDEYRKAVDEGKEKEKAEKGKGLPSTLWAPENVESLNLDRCMRLLPHDQDTGGFFVAVLERAGASQSSSLKRQASPVEKEAEIKRAREKSPAPAELAEAEAAPAVAKSEDKAEKPVTTKKEKRDNSFKEDPYSYVDPSRAEVKAIIEKFQFKDTFPKDNLLVRNEYGDPLRTIYLTNDIVKQIILNNDYTRMRLISAGIKSFTRQDSATSKNSELVCKWRPPIDGILELLPHLGDGVLIQGTLSELRTLLEDHYPALEKFKRSEWKEEMEKREMGAAVVKFNAGNSDGGELKLPMYLPIWKAKMSLSLMIDKREKSILSLRTFGEDICKPPPIQSDQKTTSTSTDPTPAEKEAQKMEELVAGDAEDDGKPGLALATEGEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLH3</accession>
    <name>A0ABR3BLH3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612019.1">
        <property type="nucleotide sequence ID" value="XM_066760073.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992475"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0243652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="305" mass="33348" checksum="412F258F6E7675F5" modified="2025-10-08" version="1">MSANSLVTAITHNIPFFLRAPAEALIGEGCYNTLVYDFNITDGECLKYALSKGLGFGIVIGGSIVKIPQIIKIVSDQSARGLSLSAYALETVAYAINLAYNSRNAFPFSTYGETFFLAIQNVIITLLIIHLAPQKGAVIGAKPLSSKQNTNRTKVLTGAVITAATGFFLWSETFCPLSLLSILQAVTLPLSLISKVPQIMTNYKYRSTGNLSAFAVFNNFLGCVARVFTTKQEVDDPLIFWGFASAAVLNAVLAVQMIMYWKDSEEKEEEVRRHNASEKGLPDVLERTGGILEVDTGKRWSRKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLQ6</accession>
    <name>A0ABR3BLQ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104988</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612095.1">
        <property type="nucleotide sequence ID" value="XM_066759448.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991844"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="6">
        <location>
            <begin position="42"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="207" mass="21984" checksum="F323869A8D80D3BA" modified="2025-10-08" version="1">MDSRTSAALEMFVKADVGEVLGKLTLDEKVSLLSGADWWHTVPVPRLGIPAVKCSDGPNGVRGRSHFKPTPATCIPCATALASTFDPTIISKVGNLLADECQAKGASLLLGPTVNIQRNPLNGRAFEGFSEDPHLSGMIAAAYIHGLQEKGIGACIKHYVGNDMEHQRSSGGYASLLALIPAKYVPNITGGDRAVDVRIPERALREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMA1</accession>
    <name>A0ABR3BMA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612121.1">
        <property type="nucleotide sequence ID" value="XM_066759474.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991870"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="665"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="386"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="726"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="799"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="483"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="552"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0243754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1088" mass="117882" checksum="4457E4707A31BC7B" modified="2025-10-08" version="1">MASPYPDNGSPVPSIPFPSIHNPNPYTQPYPYNAAGAYYRQSQPYYPNPPPIPYPSYAPIPMGGAGPGPATMQNGYGGYGEYGVYYGYTGYPDYQGPQAGYQSGEGDDYSDPSKTPGSTHAVPQPPMNMVGPNHNPHLGMPQQFPSYPPNHPYAFGGGVGYPQGYNRPPQHMHQHQHHPQPQHPQSHFHPQHQQHLQQQGPYGGYGYQEGYHGVKLNPAAQGFKYNRYQQQQQQQLQQAQAHAQAQAQAHAQTQAQAQLAQAPPRQPVHTQPPQPPQPPPAPAPAPIAPSHNQTSEPLQPIPNGHSHPEPSIPSTRTEEKESQSTKEQNPASAPVAVKEEEKETVDDEASFHDASSAIAAPRWNFVHPSSLSSSSAGIATSSLKMNNHAHSQRIRLVKSRPAEESDGNSYAMEVKAGLPQEIVVDEQLPSRSQTQTQSQRKGEGRGEGSRKGRKEKKGTSKRVWKTGEKKRVELVFGEVVPEQGKEEEEKAELVVEKPVVDGTKEEKVEKKEVSTPTRAPAQTQTQAPAPAASPAPAKPRSWAALLKTPTHSSPSTPDAVPSSSASVSSTTEAGPSRPRPSTSTSPSTPNLTPTVNGLAQPQPSPQAQGGQPQQQAKTFNYAAAAMSSVPSPHEDLVKLLSEGVSSIRGPVGLTAKEKEALMVPRGLINTGNMCFANTILQVLVYCPPFTELFEEFGKRLKADLARKTPLLEAMIVFLREFVSSPESSTSRTSTPKGKGKDKDSRKEAFIPENVYDAMKENKRFDSMRRGYQEDAEEYLGFFLNTLHEEIIYLLSRTSTTSSSIPNGQSNDPSSRKIERPISPGAGANGDADSSSGWLEVGKKQKTHVVRATESRESSVSRLFGGKLRSILHTPGQKDSVTIEPYQPLQLDITGITISSITDALRAISTPEIIHGVYSAAKGGEVDATKTVYVETWPKVLICHLKRFVYDTEEGGVVKRSKAVAYGVDLVIPNEIISPARRTSTPIKYALFGVVYHHGSSASGGHYTVSVARPSLSSSASSTPAGASASASSSSTTMASRWLHFDDENVREVREEDVVVSLDQAKGGESGLVGGRERCAYLLFYKRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMD9</accession>
    <name>A0ABR3BMD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fcf2 pre-rRNA processing C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106417</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611118.1">
        <property type="nucleotide sequence ID" value="XM_066760846.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993272"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="351"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0240619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="473" mass="52275" checksum="A7F2FE7BEF0281DB" modified="2025-10-08" version="1">MPTPRVTRSRSSTPLSFRTGTQSTPQSGSIAHPGSHHKTSDELALEEAASILHTPTIRLRSLDSADTDVLDGGSARALRHKRLNQVREEVEVVRERSRSPQRDEKRVEQSQGPEREEEEEEQEIGNSEQTPVDGDTDDEDDEASRELIGVSTSSDDGSTQLGEEGDTTLSAPLSAGQIFSQPREAVESGESASESDSETQSVNSSDSSSESGSDSESDSEDNSSDSDSDEDDEEERLLQAAREAAKANTASNRDEKEKANEADDEVVLRFDKEEKEAPIPDLTVPKLPETYLSFSKEGRAQTSTPVPSASAGSSRLPSRSSSSEKTPVPELDDRPYERPLSKREKALQPRKATTSELWASIPTPRADILPQMRKDYRALALANSLDPKRFMKGGSKSEKVPESFAIGTMVETSRQIRDTTLTKDNRYRPGQVVQNLIRDQDMEGYAKRKYGDLQWSKMENGRGKGWKKRAKWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BME5</accession>
    <name>A0ABR3BME5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612327.1">
        <property type="nucleotide sequence ID" value="XM_066759680.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992079"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="53318" checksum="5A18E301AF7C3B7C" modified="2025-10-08" version="1">MSSKTPEAVAFDTPEQQSEQQPAQGDGQPMIDPSLMEIATHPPIAEQQSPKADAAPSHQQAPETHDEHLHTASVDDRDFIFSEPHTLGITESIAQAPDPKPGDFMPPRLGDDEGIDLEALESQVDDDMPGSPTAKLMRAIAPPLALQSQPIWPAPPPNSSVNLFIGRALLSNGNDNWPLKPNDIVNWIRKHYPSEWDGDEGRCSAHRVRTYLARKGADMYYEKLNQGCIAGWRIRQNHLWRFENGGFQGRGMKQEEAIANAQKESEAIATAARKAAAAEALAAGHPNVKVSMSQPGVSDGMPSLKRPRMKQPLRRRPIKTRDLPAHLGMDALGHPDQYAFNPSPHHHDVHEPQTLYSTLDQAAAGPSTSTSASSHAQHTPTDHEHALQQLHEQHQAEHHHEHHDHHADTLSFEGLTSGNGNSVDINMVQQAMQAAAGQMDDLEMGMQLPIEMQMHSTEHDDDVEQREYDFGPGAFGTGQGYTYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMK9</accession>
    <name>A0ABR3BMK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611859.1">
        <property type="nucleotide sequence ID" value="XM_066759913.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992313"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="218"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="651" mass="72844" checksum="B8F003E83680FF7A" modified="2025-10-08" version="1">MPHRDPQARARDRHHHHHHHHHHHKHPPSTSRSALDTGLGILVEGSMHVHVKVHDAEQFWREIELVVTIPDSPTLDQLDNTLRMFVSFCAAYHDKYLPSQSDIQQAVAMLLDSDLFSYYDERMVGIMMSDAQENTNPHDLKWRKLLPTLGEVVGLDVEETFVLGLPPIETRIRLPATCLMYEVARVQKLTSSELAQFDDQFIDHLFDLVETTWDQQDERLNYAVIRLIVALNEQFMVITLPSKHHTRVHARVGKWEEQNHLGGSSVPSSGGDGEGGHTRNHHRAKSGNTTQSGGYTHDHQEEPKKNNRVLVVLMRRLGSSKTFGENMIFMLNRAENTPDDLCMQLLILKILYLLFTTPGTQEYFFTNDLKVLLDVFIRELVDLPEECEALRHTYLRVLYPLLNHTQLRSDPYKRPQIKLVLKSLIANSHIREIDPTTLRLVERCLEEPRKLERSLSAENVQNALHQNTASTITLDALSSALPPSKSQLGTSIYTSRDPIRQSSLNDVSSSLTDAKARPHSAASMASTCSTSTETGARATPPTPTKRRKPPAPPRHAHHRAGACARKDSSTTSSSWTSFDSDVDASMSDSTSTGASVLGSSFGAGGTVMSPTSPISRMDDLVREGGKGVPPPIIEVHPVGREQPMGWITFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMM2</accession>
    <name>A0ABR3BMM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612409.1">
        <property type="nucleotide sequence ID" value="XM_066759762.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992161"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0244042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="210" mass="23234" checksum="6ECED2CB3B6FE522" modified="2025-10-08" version="1">MSHTSAQLLDAFLSTTDDKIIPLTAEGVAAGCKVFGAAILRKSDLSVIAVATNNEISSPLLHGEINCIQHFYALPADQRPLPSECLFFATHEPCSLCLSSITWSGFDNHYFLFTYEDTRDAFNIPHDIRILEQVFKVPASSESPTEFANRPLYNKSNEFWTARSVSELIEDLEGDVKEAMKTRAQEIKVKYNGLSKVYQDGKGNAGIPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMN1</accession>
    <name>A0ABR3BMN1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105782</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611535.1">
        <property type="nucleotide sequence ID" value="XM_066760231.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992637"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="9">
        <location>
            <begin position="73"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="10">
        <location>
            <begin position="203"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0242153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="246" mass="27956" checksum="1E85890B79964A0D" modified="2025-10-08" version="1">MSTQHVFGTSSTSSHRSASFSAPETVKLTTHNQYLTPRLLASELSPNPLLQFNAWFASALQPSQGEVAAGRKVSEPEAMTLSTATAQGIPSSRIVLLKTVDKTGFVFFTNYTSRKSEELLANPYAALTFYWREVSRQVRVVGKVEKVSREESVEYFNTRPRGSRLGAWASKQSQPVEEGQLEEWVKSEEERWEGKEVECPKFWGGWRVVPFEVEFWSGQPSRLHDRFRYTRPEGSDGEWEIKKLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMR0</accession>
    <name>A0ABR3BMR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611904.1">
        <property type="nucleotide sequence ID" value="XM_066759958.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992358"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11281">
        <property type="entry name" value="ADF_drebrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11819">
        <property type="entry name" value="SH3_Cortactin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="5">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="514"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="617"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="575"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0243537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="71814" checksum="66DE69FE693829EC" modified="2025-10-08" version="1">MSVVFTDPDLQPTYQALIQGSAPYDWVLFNQPGNELKLQATGNGLEDLEEEFMDGRIQYAFARVRDPTSHLDKFVLISWCGDGVPEFKKGLYFTQSAQVQNKFLKDAHLVIQARSELDVAPSYIHKRIQESSGSKYSAPAAAPSIAAASSVKPAPSYRPSQGLGGSQGKPTTVTTPTSNFGAPPPQRAPAPSVVVPSPLPATHEDRSMNSGLKSSPITAAPEPAKPSAPTTVAAEPAKPVAEDRIAPVGTAYTPIKLQPGKLANRWNPGGVQEERNEESAVRGPSIKDRMAAFSGGHAPSPVLPQPSGNKLSWAERQAQAKKQREEEENENAAASNVKTISPAPTGSRAIPPLPAASIDSSAAAPSPPPASATISSPVAPAPPAPIAPAVPSLIRNSVPRAASPDSDEEKSDDDDWGAPPPPPPPVPFKPEPVMEAEPDAPAAPPPPPPPPPPPPPPPPTAPAQAATSSDPQIDELQRLKQDLTLEETPTAGPPPPIPVASRPGAVETAPEPSAVGKRAKVLYDYDAAEDNELSLREDDIITQIEELDEGWWSGVNADGQSGLFPANYCELIEDDSAPAAHPQDQVAPEAELETEPATMHHSPPPPPPPPPAPSADAEGTIMIAAYDYDAGEDNEISFKEGDQITNIEKVDPDWWQGKCKGQEGLFPAAYVVSPDEYPLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMT9</accession>
    <name>A0ABR3BMT9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612103.1">
        <property type="nucleotide sequence ID" value="XM_066759456.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991852"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF98">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="69"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="152" mass="16177" checksum="4A0DAB29D8304A61" modified="2025-10-08" version="1">MSTAFIDLDVEAGKCLDIAGLYNDSVSSFRWRGITAIMPASGSKAEKTLLAEVSGEAHAGERIPDDTMLTAGELVAIMGPSGSGKSTLLNRLAHRAMPPKAKLAGDIFINDVHTTISNIRRTSCYVEQQDHHIGSITTAETLAFAAKFGLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN00</accession>
    <name>A0ABR3BN00_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612533.1">
        <property type="nucleotide sequence ID" value="XM_066759046.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991431"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="559" mass="60475" checksum="E830D3820624403A" modified="2025-10-08" version="1">MIPQLLYHSSSPSMYPTNACSSLLVLRFSGPVRVSSVRITPEGVRCPDGSGVTYPPKWTGQLHFNISSSNPVNALVSTNITYNTALHPVDYPIDMPQGTTSRMMMLRAPVEKLSISVYGYADESPGGDSTQKDTVEDQKPSNTTLEEEDPSWLWRWAGDSQDSLIDLLNAYTRPEIISRTLECLDLLSDLDDSIIPSLLERPDVLEYLFRLPRSTFSSKITNNYKWALHPSAGPLLLTDNPFTPLLQPGTSARHAAAWQHLSLGKAALTCLVNTGVSVMEYDLMRVEKGEEKSNLARLLDMGEKFAQEGDAEGLNMVLNLLDSAELEIVDSTVAQEYLARTIPRLSVIAIALSRNGSGKGNDTIRSLKVGEKYARLVVNALLLCSTEIIDGKLAFPIARNLAEPYLPFLESSDPLRIAFHASHPSPTTDVLSDADPAARALARLSHAISSSSPSTSSSLAINPLIRPSFSASSSSITHVLPPSTLLSFLAPQLTSTLSTAISPPFGIQPAATYASPELQGANAWAGKVYTSHEFRSRELVGLGIGPGGRAASKHVDEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN33</accession>
    <name>A0ABR3BN33_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612250.1">
        <property type="nucleotide sequence ID" value="XM_066759603.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992002"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="181" mass="19814" checksum="9C75CDDEFD337769" modified="2025-10-08" version="1">MLEEPSAPLSRRKGQAPFGRSLLLHTIRGQDLNLPLTALASNCYRHCPPLFITASHPAIKSIFPVATDSDPSATYGVLIRLLGVPVDLHTQRTIRSYPKARLIVTEAIKSIQIGPLDNGKGEQNSAFDQVETSNLWSNRTVCTLAQPGRFQVSGSIRRRSRQTRKDTRLVLDGGAEATKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN46</accession>
    <name>A0ABR3BN46_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104622</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612574.1">
        <property type="nucleotide sequence ID" value="XM_066759087.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991478"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0245490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="713" mass="80264" checksum="571D085DE6FA9A65" modified="2025-10-08" version="1">MASSKPLHQLPLPARTLQSSLPQLPLSSQSSAQRRSTIFKGSTSGIWARVNPMWASWPIRLSKEEAEDLGVNVERGEKIDVEDILKSWEPNDVLQQGAENGLDLKSSKRREKLEPIILGISPSALKESLPHLDVGDLLEICKAGKQPTSGNSAREIFIDILSGRKVLASDNYGPWATRYSGHQFGQWAGQLGDGRVVSVLETESEQGGRQEIQLKGAGRTPFSRADDGLAHLRSGIREFLGCEAVAALGIPTTRALTLLTIPLPYLPVFREGTIHPSSLLTRVAPCFIRVGHFEALNPPSSAAGGRQFFVGGGGWIDDQTEEEGEEEGNGNLEGLRDLGDWMKEMMEVKEGWKSWVDEVIKKNAEMIAKWQVYGYMNGVINTDNVTLMGITIDYGPYAFMDVFDQKHVSNQSDPSGMYAYRNQVSRIQFALSKFIDSVSPLLGYESIHSNIPKGWSEDKAREDIKDWGEKGKEVMKGWEKVFEEHEEESEMKGWYQRFGLKTEQQYDQRDIKYDFLNYLQVHDLDFHTAFRGLCEFSPTKASPESGDKYIKEFVPHWVRSAADKSASDDSLKLAEEDFVRWFGIYAKRANLEDEKSAWDSTDDWEPARAADMRKRNPTFVLRQWILEELLGKMEKALTDPYKAALSKDDVDKQKVEEGIRTARTELWKILEMATNPFENWGQGEGSEEELEAQRRLCGVGAKEMFGYQCGCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN62</accession>
    <name>A0ABR3BN62_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612587.1">
        <property type="nucleotide sequence ID" value="XM_066759100.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991491"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="194"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0245503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="463" mass="50748" checksum="8B7C026E73F8B8C7" modified="2025-10-08" version="1">MPTIRSLRSTIASCVSTISPHAAFHYFLHALSASIRRLDLSRDPRKTLNRVRQHKLTLANTLPRAFMLLCASYSLYIMTSPPFPFKLGIPIAYIVAVIFPITSQFVWPATPIFAWLITFFSARFISSGHRPEIHVALLPALESVLYGANISDLQTRYTNAFLDVIAWLPYGVLHFTLPFVVAVILWSLGPRGAVQFWGLAFGWMNLLGVVCQLLFPAAAPWYEIIHGLTPADYSMAGSPGGLMRIDRVFHSSGYTNAFGSAPLVFGAFPSLHSGCAVMEALFLSHFFPSLKGLYWGYVGVLWWATMYLSHHYLIDLVGGACLSVLVFYLCMPEGFKDVDQIQWEAVEGDGYEMIGGPKTGTGPEIDLDEEIRKLEEQGEALFEHMIGEDEESRIDTWGEGNSGAAGGGNVSGNESADSAGGSSKGKGKQAVNKKPKMKEQRSVSWGETKVMGEGAQVVSEDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNL9</accession>
    <name>A0ABR3BNL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612571.1">
        <property type="nucleotide sequence ID" value="XM_066759084.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991475"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0245487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26057" checksum="BDCD31D8FCF1A01B" modified="2025-10-08" version="1">MVQMTRPSEKRIHLTRHAQAEHNVADDYTIADALLTALGREQSRQLNEATKNGVQRTAELLVTSPLRRPLETMLLGYPELKVRLEKAGKSVILLDILQEVGPYPCDTPTHPISALKASNNGIFSTLDFSTLSPDYASKEGIFAPANGETRAKLVRKWLRERPEKEIVVVAHGDILRFIVDGQQSSRPWNNAENKVFTFRSNDASDDSLVEADYQVEARDATAEPTSSEIKAGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP19</accession>
    <name>A0ABR3BP19_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612595.1">
        <property type="nucleotide sequence ID" value="XM_066759108.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991499"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="261" mass="29056" checksum="FE51330E9DFB8C99" modified="2025-10-08" version="1">MSKNTECCPPQSSSNPSKPKVPHPPSDPIGYKYKGEFKSVANYDKVYVTGPENAKHALVVIYDIFGFWDTTIKGSDTLVSHLTSTFPTKVLMPDVFKGKPFPVEKDGDKETLKKFFGTTAKLDDRLPEVLDFAKELQKSYEKVSIMGYCWGGKLTLLSLAEGTPFDAGAVVHPAMIAPEDGEKLSVPLGFYPSHDESKDVVKKIVHDFKSKPFGDKCGYHLYDTVHHGWAAARANLNDPENAKQFEDVYKRLSEWFASVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP30</accession>
    <name>A0ABR3BP30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612523.1">
        <property type="nucleotide sequence ID" value="XM_066759036.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991420"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF2">
        <property type="entry name" value="KUZBANIAN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045207008" description="Zinc metalloprotease" evidence="4">
        <location>
            <begin position="33"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="728"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="6">
        <location>
            <begin position="308"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="5">
        <location>
            <begin position="540"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0245439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="921" mass="98058" checksum="83382605CDAAD370" modified="2025-10-08" version="1">MWATIKVWRPPPIHFLSLVLVMVVVLLTQVDARSPHPAPLRRVTTTTSHLSILPRKPANGLVPRYASLLPPPPSTLKHSDSLVLTLDLPNLLPFEVKLFVKPSEHIFHPDARIKQGQQVIGELREEDWRLYTGDVVHPGYIDRLTSLHAIGAHQPLSEKSQIHGRASVMVHHPGNLDGHDAVWEGSFTVGGELYNVMTRENYERVKTRQDVAVEGVGRMVIFRQSDMRHDQGTNRTTTTIPSCSHDSLAFNHPSTNPLFTTARDGTSSFSFLNPLGMFWKRSDTGGMTGSSNYINSINDTTGCPDTQQIVYMGVALDCNYVAAYGSPDAARTQVLNNWNQVSALYKSSFKISLGIIELQVQNMTCPSTPVSGEEWNVGCDANVTLDTRLGDFSAWRGARGDDGAGLWHLMSACPTDSEVGVAWLGTLCQTDSSQQSSGTVSGTGISTASKTEWSLIAHEIGHGFGAIHDCTSGCSLSGSCCPLTTNTCNANGQFIMNPTTSTTEQTFSACSLGNICSNIGNRAVSTSCIQTPGQRTVISLQQCGNGIVEDGEDCDPGANTTSTCCDSSTCKFTSGAVCDPTSSTCCTSSCQYSPANTTCRAAVDDICDYPEYCTGTSAECPEDKTAKDGTSCGSDGLACASGTCTSLDKQCSTAGVTMGLSKACGQRDDTSCVVACKDPNSTNSCVLLQTPLVDGSPCGYGGHCYNQTCESGSWQDTAAAWYKQNLQISIPVTIVVGLIVLAILFFIARCIYRSCTRRGGSAAAAAARKTKYVPANGDPYGRPPPPPTTGMQMSGVAAPQPALQRSFESRASVEPLMAGSGAGSGAGYGRPNSEYAGHGYEGDGYGYGGQGYEYQAPQYSSSSFVTGTGGRQGGGGGVYSQTGGWVDDRTWNGQYYGQQEAYGRLKGELTVTKYQDICDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPH4</accession>
    <name>A0ABR3BPH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="3">M1Pi</shortName>
            <shortName evidence="3">MTR-1-P isomerase</shortName>
            <ecNumber evidence="3">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MRI1</name>
        <name evidence="4" type="ORF">I308_104953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612901.1">
        <property type="nucleotide sequence ID" value="XM_066759414.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991809"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0245817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="393" mass="42217" checksum="EAC9733DB7413A98" modified="2025-10-08" version="1">MVAAAPSNKKPLPDMMTSIRLDQSGKVEIVDQLLLPHSVVWMPVSTPEEAFDAIKSMRIRGAPAIASLAALALRSYLNSSSSPVSSSSSSSSVISWVSQTIDYLQSSRPTAVNLGEAMDRIRAALKDSKAQNQGAGDIIERVKKICGDVHDEDLERNMEMGRLGAEWLWKKRGGGKKGLKVVTVCNTGSLATSGYGTAIGVITALFEENHLDTAYYAQTTPYHQGSRLTSLELTTLQIPACMICDTMLGSLFQHEDIDGVIVGADRVVKNGDTANKIGTYQAAVLAQRHNVPFMVVAPITTIDLSLSTGAEIHIEHRPAIEATQVRGLNTETGKLSVVRISPEGVGEGDKPWQRVYNPSFDVTPAELISAVVTEKGVAERKEGEKSIDVASIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPP7</accession>
    <name>A0ABR3BPP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613109.1">
        <property type="nucleotide sequence ID" value="XM_066758661.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991039"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="389"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="473" mass="50787" checksum="5222C677F88D28BA" modified="2025-10-08" version="1">MAASIESTSGTSAGPSIVASGLPSLADLVRAGSKRTRVVYGAEASAVEDDGLARANKIKLATKLAIEYKDVQTLPPILQSQQAGPAGPKPPKQPSITVSGTAGPNVKLIGGPEAERASSSTPEAVAEPRSLVKFRHQQGFAAEGGQATSRLSQALMRKKEAREVKPEYHPEWKLTRVISGHMGWVRAVAMDPGNQWFATGAGDRVIKIWDLASGELKLSLTGHISTIRGLAVSDRHPYLFSCAEDKMVKCWDLETNKVIRHYHGHFSGVYSLSVHPTLDVLVTGGRDASVRVWDMRTRANIFTLTGHTSTVGDVKTQDSDPQIISGSMDSTVRLWDLAAGKCMNTLTHHKKSVRALAIHPTEYSFVSASSGGNNIKKWKCPEGTFVNNFVGHEAIINTLSVNSEGVLFSGADNGTITLWDYKTGLPFQHLKDIPQPGSLDAEAGVFCSTFDKTGTRLITGGADKTVKVYSEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPT1</accession>
    <name>A0ABR3BPT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613166.1">
        <property type="nucleotide sequence ID" value="XM_066758718.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991096"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="74"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="506" mass="56304" checksum="A378ABAC695702AF" modified="2025-10-08" version="1">MMANLQPIVAFLKRTYPLPSLDPRWVRECVDALVEAGRAPSIENVHTEFLYSDLSLCTRETPIFPEGELHDMIIFPKPTLLQIHAISEVGHSAYQIQTVMEQRSEVLSGRTRIRGLDDDGENEVEEGKVPPYPRGMLRLELGDGRRIVRAMEYKRINDIVLGQTSLGSKIVVQNVRVLRGILLLTPENFRVLTDSCVEELEDLQKDQFVRDLQRRLGKLGPDEDVEGLVNLPPVIPPPVKGPGVQASKPARNVPRQPTRASAAQPVRATPQVPAPPDQHVSKRPAPSNAVAGPSNSKKARETAIVEEDDFDGFDDFDESFLRQVDEAESRAYATQTNLASRPAPVETDLYESDDDDFMILDESMIRQLDHLEAQAKRGQTSSAITKTKSVSTQKRRSTANEVDDLDLENDEFEINESFIRQVDEAEAFALANSSSTKKTTRKGVGSSSTTARSATRSAVSDVIRNGTMQSTKDVVWKQTFLTDNSSDEEVDSQKENRVPEVIEISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPY0</accession>
    <name>A0ABR3BPY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612838.1">
        <property type="nucleotide sequence ID" value="XM_066759351.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991746"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="603"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="854"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1036"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1255"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1330"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="860"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1043"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1261"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1345"/>
            <end position="1359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0245754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1359" mass="150126" checksum="4614098911E53439" modified="2025-10-08" version="1">MSHPPPLSPRKPSPFPQAITVNPGAALPTPPPLPPRPTSSINRDTLPPPIRTSEPVVIAASEGTPQPSEEVPRVQVAITPASPDDERYTSNVLEQASQRLSNASDGQPIVNRARDLDVEPETPAGNGLANNVPINKGRASSTNPLVSTPNKDIVGGATSNRNTSHIPLTLSLLKQVPSSGLKDLPTMRSTQWAIFTTILVLLAHCGLPLAWLIVTAFGSYYLITHLDGFVPPPTQEASMQEQKEKIMQTGDGVEAVGWVNHALYALFPLISTDVLTPFVDLLEDALSEEVPSIVTSVRLTSPALGSQPLVLTSLRPMSDQEWFASLSSSVTKSDQKSGSKTHSSPAYKVPASPGPESLKRAQHGRQTPSTGSSNLIDHRKPLNQPSPTYSGSDAEIQDEVQKRRKRDRLLHKITHRVPYSPSTDHPNLPQSPETDTTQQNQPQYRSGDCLEDETDTFDEPRLHGGWDEEVDEEDPDAGQYVNYQVGFEYKRGAEAMQKGRGLHCLAYIGIGVKGLGKAEIPVYIDVLYIKGVINLRLLLSPTPPFITTGSFTLPSMPEYDISANPLKKGAFNAMDLPLMKPYVKASFKSVLASFLHPHSYTLDIDRLLLGAESSYRTEHIGVLHIIFHGARDLPKADTMGSCDPYLKVGFEKAKKVMFSTRTIGRSRNPVWEEECFILIAADAIKAGEGFRICANDSDRFSADDTLGVVLLDLAELIDSCRQGMTHRADHFVADRAAKDTSGTLSWSVEFCPLWQMSPEETKERLAQGRMEKERCEPPRGAEEPWWVRWMKDMIPGEDGWETERIKRRAETKEWLCGRKEREVWEAEVGASEERPSGILQFHIHQCLDLEVESTAGTYTAQPQRPAGGPPALGHVTDRSANEISDPPSAYCEVHLNDKLVYKTRTKEVTPMPYYNAVSERFVRDWTKGKIVFVVRDARDREHDPILGLVVINLHDILKETSQITRWFPLTAGLGWGRIRLSLLWKSLKMSIPRGISGYEIGTVQIKGFVFTPADDRNDDLRVVIRTDSDTRKVRLVGGENGNSSTVPTGSPSSSRFSTPSSSEQYTFPASTHPALAIMYRHSCSIHMSIQSSKAKRRVLGKMKLLGVGVIRLNDVPDGQGSRRVAVWEGVKGESNDWDLGFEEMADTPLDEDSGEMLSTPDIAAVDKSLSPTSHPDSLALSRVRTSLSKRSSRSVVSSLRSLPGQRRLIGYIDVSWVLAPGISAIHRKLAKHDLRFAKVFEAWESARDEHDIVHEMGNEDSGSDSENEEGENSGEQEFVHLQENDAEDMSPRRAHSHALHKQHKGLFQLKIARTGKFVKDKLSAKVYNATNHGNSGVQEGYGRTRGADLEVEKEGLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ00</accession>
    <name>A0ABR3BQ00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Solute carrier family 39 (Zinc transporter), member 1/2/3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613234.1">
        <property type="nucleotide sequence ID" value="XM_066758786.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991164"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045208814" description="Solute carrier family 39 (Zinc transporter), member 1/2/3" evidence="6">
        <location>
            <begin position="22"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="42535" checksum="BD940B6FAE5F8D73" modified="2025-10-08" version="1">MTSRSIFVYFVAFAVVGFVRGQITAEEEHDHDHDHDHHDHQDDAVVTDAATHDAHAGHTHAHSSSDCGVTELKNYNLAIHIAAVFVMLVASALGVFLPVILGKLGPRNKLFGSLFSILKYFGSGIIISLAFVHLLIHAFFSLTSACAGDMEYESVAPAIAMATVIVVWLVDFFGSRYIARQNSCLPEGGRNITAASSSSPESPAGKKIDGISTPMTELACCGPSKSEVTPFDGAAKTAHWNVQLLEYGVIFHSIMIGVSLGAMGTGFNTTFAALVFHQLFEGLGLGARIAMLIWPSGVSSTIKKWTMCLAYALVTPVGIAIGIGVHESINMNGRAILLSTGILDSISAGILLYSGLCQLLYREWVVGDMRDASTGEIIVALVSLFLGLFAMSFIGKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ28</accession>
    <name>A0ABR3BQ28_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pheromone-regulated membrane protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104764</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612714.1">
        <property type="nucleotide sequence ID" value="XM_066759227.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991620"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="769"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="863"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="462"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="746"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="901" mass="99625" checksum="4F7FF080701478A1" modified="2025-10-08" version="1">MPSTKGTHRCPSQQEEGGPSDKWTQQQEVDVDLISSHSSPPTCRPNSLLHSSSRDSPLLTPRRPTCGNSTSIPRSIGQEHTTYGCRPNLKVRWQSKLGEDYRTDTRSLHSPRPSTAPSEEDITAVQRSITSIFRRPQGYSPRQSRSDLESGLSDTRSSVLSFESDLFVRPRPVRRKASSRRSSGVLSALLGLYSNEASNKKRRALRSFLRYKDKDNEDNHRGRARKRWSRESLFALPSHNSGRSASRSVSRGAINAPDGPEVAGRMKDERKRVRRNRKHRRLPHRSQDLNQPYIPSVRYSNPLEPAPNITVAQRFRTFMTGRNAPVTLLGAPDAVDHTGSQEESRYRTMAALMITTNSLMSIGSPTLVHVAPASGQGGESSGGHRKISWYEGVAEKDRAEQERELEEERDLGLIDGEEDNLRTLEEGMYQGKGKRKRTRGKRIQREIAVTKHVSNLVQRKKFIEELAKAVVNYGAPAHSVEAWLASTADILSVEASFIYLPTVLLVAFRDTDVHSTDVLFIRPSGGLELYRLSLVHEVYRRVTHDKISASQGRRALKRIGRETVPYSRLTLILTGSVASAISSRVAFSGSFVDILMSGALGALFTIVQFTISKENRVLSNIFEIGMAGILSFVARGLGSSKYFCYESLASASIVLILPGWHICLGALELGSKNIIAGGIRLVWAVVYTLFLSLGLGIGSEIWDSFGPPQPGNHSDSSDANTTEVLCYRDPNWDYWWYTEPSDWWLFLLVPIFAFSLAVWFRADWRSKDIVIMVLVACAGYVVNYFLSGQISQINVTSAVSAFAVGVLGNLYSRLGRGSAFPSMVCGILLLVPNAIAAAGGLGTSSSDQSGSTDSNNQQEINTAIIVSIRMILVGVGLAVGLFASTVVIYPFGKKRRYIFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ33</accession>
    <name>A0ABR3BQ33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613265.1">
        <property type="nucleotide sequence ID" value="XM_066758817.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991196"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052358">
        <property type="entry name" value="Aro_Compnd_Degr_Hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563:SF2">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="21"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="318" mass="36227" checksum="85BFAFC7DA149454" modified="2025-10-08" version="1">MPSLASTTSTRTEQPCPPGSWDVHHHIFDLDKFPLAPTRHFTPSSAPLHSFEAFQHSMGIDHACIAHGLSFGTDPSSLLYYLKYFNGTGRAYACIDIEKTTDEQIHSMKDQGVIGIRIDYHLHRAQHDMEQQIRCMKRYADRIAPFGWGLQIYHPHPEYYDSLAPIIASLPVTVVVDHFGGLKTASLLEFQGIDTSSFGVAKQPGLKALCNLLKERKLWIKLSAPYRCSEDPTFQDMKPLVRALVDANPDRVLYGSDWPHTQPFHRRPKGLKGEDVEEFLDFDDKAWVNQLKTWLSDDEWNKLMVKNPQVFTGYEGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ40</accession>
    <name>A0ABR3BQ40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612345.1">
        <property type="nucleotide sequence ID" value="XM_066759698.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992097"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="164"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="357" mass="39439" checksum="7A7BFCE8D6F764CE" modified="2025-10-08" version="1">MAPKSLLPVVLAADNFPNYALPPSPPPSPYVPFHLTLPDYQAHLHPLGLLRPDVVSAMQSYNSSLIEAGKSSIWGFVAEGKGDETGKWQTHILAVYFNENVARQGKDELGKVMKECVESWKKDGLFPGPLAGWRNELYAIYASPQSHAFKGPVNKPFGNVAFHLERAACALFGLATFGVHLTAYEGTGEDMKIWVPRRSKTKATWPGRLDNSVAGGIPAGMTPIDSIIKECDEEASLPEDLVKRYIKNVGVATYFYITADGFLQPEIEYLYDLPLPPQDSAEYVRPAPFDDEVESFALLTIPELIDALHSGDMKPNCGLVYVDFLIRHSFVTPENEPHFLEISTRLRRRLGVALPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ70</accession>
    <name>A0ABR3BQ70_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613297.1">
        <property type="nucleotide sequence ID" value="XM_066758849.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991228"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="146" mass="16380" checksum="BDAC1EE517BF8146" modified="2025-10-08" version="1">MKHEHHHLRCFIRKRGGKTMVELQTLDSGTAYMPNRDPRGNIPPQQHSTGKIPHLGHAVTLPNTGIVAHELSAIHKRTSRRNRNSPASPLYSARDSSWDALSAYIMEDVSLALHKAENHADEINCVPEDKVACRGVRVRNDKIIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQA0</accession>
    <name>A0ABR3BQA0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613331.1">
        <property type="nucleotide sequence ID" value="XM_066758883.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991262"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="916"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1377"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1860"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1817"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="949"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="977"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1389"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1871"/>
            <end position="1880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1880" mass="204210" checksum="A781C76F097CE50C" modified="2025-10-08" version="1">MLRPPLSSPSHTAETIISFGSTVSSHQSFSNTALTTPDLGSPGKTKSTLEPLLQILERAEESSKPSSPSLTNSSKPFERPTASNTGLRIIGGVKVKDVASRFEQMRSAQTPSPTPPERHQPTAPRRLPIARSTPPLQTTNNRSTTLSSNGTESTVRPTTSVDQSTDFELPSIPVKLPSAETSYLPSPTHDNVCNDSPNSKNGPTPLRRDRGSTKKMIQRWESRSSTPTHPEVDTVLQNAHGVFSREYLDKKPLPPPKDNPDDSAIIVLPRHFSPSKSLRHKPQSSSTHNSPSHLRTPTKSGRGQNNLSPSPSGSNHSPQNSPSGKKQKVSPLKDVLNFLGARRKGKGKEKEKEIKKDYGALIDENQGRFGVFIPKDRMGSAEMRWSPDFKPTIRSDPIIYLIPTPCSSVSAWDSWLPSWATLTSDALSITYCPVFPTPRTGSSDTPRRCSGSSIKSARGVPFSRISAPNPQTPSDKTFSIQNCLDVRVMKKDELKSRGIPLAPDGVGAEVIELTWEDRSRSYIAVEGSEGRNAWLTAIRGILPRTPVLPPITPSETPFGSISSPLRHSSRHSSPLSIPHRGSIGTVEDAGFGSFPSIQKVGDEWVAGGPLHTLSNDLESLRSRPRLREDSPLRESVSLMFADKLPSQTPPRQSSVPQPEVGRSTSHASSEASQRILEWQAPVQNRKELSVSAQSQLLPTSFLSSGIDVGSATMPHSDTMLSFDSEDLNPSRSASQVGRVPTDVDMGEITPKQTRTAGAGEVKSKAAAWEARSALSSEQELDPFGAPTHISRITFPKPFVGNAPLASSPKISLTPTSYKADISFDHTKNNNLFNHSTSPSRTMRMALEGLLPGAPLAQFTTQPLRLHKNIGWRPNDRHASSTETLVNTPGREMVMKNMPAEAISLASTLSAPTAFEKDSASEEVINRPAVQGPRPVSSNTFGRRVSSRKPSATSQTTPPTRTVTPAVVAQPSTSRDLAMGAVSSPSPMSASGASQRSKNRRSLLPHRVPSTIYRTEIEKQEQNGHEAKEDKEPSSTSAGSPGLGEVESDEVHINAVDIRPISPRLAGVVTVKSARSPESDTSQPLPCPSVALLLELESSPILNDVHLLPPAEELALPTTLPSANLSKLLENVEVLVDHSRVMSDPETALYPKALQEKLGALHEDLTIVCRSLVKTNSEKGSVVEDSPPAAAQEPLDLSKVYGHLESLEGRTISMADPETAPYPKVLEEKLNTLHAEVTLVRKLIEETKTQQETRTFGHVAAEEHKQNDPTAVSRVLTQASSDSWAESAIMATPVLLESKSRNVEVTDGPPPQTELADLPPEQALAAAVPNLEHVSPTLIQPSMPTRPRPARLTMPAPLAPQASQYTTSRLFANTPRSPLNSAFEDDKPPTKTTFAGSESMQNDHTVTMPEPYILRTPVEAIQKEVVPQPIQSDVSEIHRKLDHLTALYLAFIDQQHEVTTSSRVAGTVAGEIAKVPGPTNAGGKRDDGEGRLIFSESEMAGTDNGPFFGRFSTIMCKGVESASASVTPTSVASQNPVPSLKEEIEAPNEVENVIVEEQVARPEAKNEEEKYAGEEVAKIMGENSDELKPLKQQELHVLSNVPTPFERGHSEKGEISSDQLAVAKSPPPIIAPMTVKFPEETLKKVEKAMGILTELDEARGFQKTQAADMGKYLTDLNGWLEKFVQNSSTELGTMSKRLDTLVGPESSDGSQGLPALVADMHSMLVEQKHRNEVDGMTGQRLDTLVMMMGQDQQRQATQESATAEILQVLERQRHENEMLLRALATDLTEEIRGDKMRFLESMQKATTVNVMLHIEEFKRLLNAEVNKSMNELGKVREEKRALEQQISDLFALKAKHGIEPRALPKVPSAAAGPPPPPSNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQS1</accession>
    <name>A0ABR3BQS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612585.1">
        <property type="nucleotide sequence ID" value="XM_066759098.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991489"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="3">
        <location>
            <begin position="45"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0245501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="666" mass="71900" checksum="E0AE87F825F4E06B" modified="2025-10-08" version="1">MPPRPSPSGPSTIEPANLSHFAIFNPNFDTPAPVRKEGEDRNKDDEDDQKEAAQILFYTSREAGGISRDKMLRQVGLAKGLMGFADMLANDDTKFWAIHSHKSRLIVYTPESGFYIYSDPAPSSQGIPDLMLVSALGRGYEDFRFLHGPLSSHTPLTSAGSSLIDKYFTRFAFNFESACLSSPSLSQWIGGFSPPSNNTIDQLLQYFKGSNGFTSDVYVVGKDGPLAIGSESTPDPALLRYLVHLVQASLPQPVPPINVTSATRQERSRPLGLSLLGLGTMKKRKDETRKASWVSLGGWAPDLRLVGVSNPGSAKQETSASSERVNIEDDKKPSSGSGSTAEKKDSWAFGWGAIGDAVESVGTVFGLGGTQPVKSPAATSGAIHGANEEVVSSTLEDNFVPQHPSDPSIHKEDDGVEAKRVLSVVDIPEIQSPSDTIDSNNSKGQVATAAPNICLCSPTPDEHATSQISADENVQPSNVSIPELEDAAEPDVEIDWDNRAAWIVCADGVLERRKICWIIRDSILIAIILPEESTPPFPLPSAKSILSFVADITQVTSATDTTASDRKQDEKQDESAWIYKFGGDSIASTGKMGAVEEQALIDLRGILKSTPSVSEVFAKTSSSHFVLAKQKIEKELYAVCETKEASLTDAEHSLRKLLRSHPEIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQU1</accession>
    <name>A0ABR3BQU1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613225.1">
        <property type="nucleotide sequence ID" value="XM_066758777.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991155"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="121"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="434" mass="48390" checksum="A8FAF0C253BDC750" modified="2025-10-08" version="1">MMMSSTATLVDEDFSIGTLKLNSADEVTEVQVTSSPKLEETTEMKDGVAVNPFNYVGEVLGAGPGADYPYAEFLPHNPPRTQSDPPLPFYDIEDRGHRAHPNAARLRAFVEARGGKVKDILVAIGTVIEGDVKLADLGEAEKDDLALLVAQRSVVFFRNQQSMTIEQQRELGKHFGPLHTHATYATPRRGDLDDVVVVYSDRDSRPDLYAFSRAELFHSDVTYEVQPPGTTMLRLLTTPEVGNDTLWSSGYAVYSSLSKPFQQYLESLSAIHSGFDQASSRTSFSKIPRREPIETIHPVVRVHPVTGMKSVFVNSGFVTRLVGVPKAESDMVLSFLKDCFAQQTDATVRWSWAPHDIAVWDNRVCLHSATFDAYPSLRHGLRVTAHGEKPLSVEEYEEIYQKPAKDWIEERFKTLGITGPARDDGKTKKKAFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQV3</accession>
    <name>A0ABR3BQV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DinB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613537.1">
        <property type="nucleotide sequence ID" value="XM_066758135.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990504"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39473">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39473:SF1">
        <property type="entry name" value="DINB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26127" checksum="77B1AC40C533596E" modified="2025-10-08" version="1">MSLPTTLNHTLVPMPTRQQSDRAEALLTLSIALIDSALDILQHHVIETFRAFLLPLYPVPATPPHIPEINYDAIVPSSRRPIARSLDACRAAMRQVAKDLSAWGESCRERGRARKAATDAHEEKRQGEKSKSMHNADRERDGLADEMERIVRVAAITPTKQEMGSTVGRELWYCSIHAIHHFSMLRTIAVYELNLDLPVEFGTAPSTLLYRGLAWKPPVERKHVKVVRTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQZ5</accession>
    <name>A0ABR3BQZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613411.1">
        <property type="nucleotide sequence ID" value="XM_066758963.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991345"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="452" mass="50328" checksum="FBBC6C7383EA4AB3" modified="2025-10-08" version="1">MDEEYDVIVLGTGLTECILSGLLSVDGQKVLHMDRNDYYGGDSASLNLTQLYQQFRGTPPPENLQLGRDRDYAVDLIPKFILSSGELTRMLVHTDVTRYLEFKVIAGSYVYRDGRISKVPSTEMEAVKSALMGLFEKRRARSFFQYLQNWKEEDPATHQGLDINKCSMKDVYTKFGLEPGTQDFIGHAMALWLDEDYITKPARQTIDRIILYTASMARYGKSPYIYPLYGLGELPQAFARLSAIYGGTYMLDKKIDSINIDPETGYFTGVTSAGETVRAKKVIGDPSYFGAGKDEPEGGKMRVIETGKVIRAICIMKHPIPGTDNADSAQIIIPQKQVGRKNDIYIAAVSSAHNVAAPNVWIAIVSTIVETSVPEREILPGLQLLGNVVDKFISITPLYAPTADGTTDNVFITKSYDATSHFETVVEDVSDVWQRVKGEKLVLKKRETQIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR74</accession>
    <name>A0ABR3BR74_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_104193</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RRP36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613119.1">
        <property type="nucleotide sequence ID" value="XM_066758671.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991049"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 9" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="369"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="256"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0247158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="400" mass="44777" checksum="886FC90BB5A4502F" modified="2025-10-08" version="1">MATASSSKLNGAARLKQSNKTVREPSPDDEFLESDSEVDEFAEGFQPGLAEEYSDDEDDGHEDEEGYEDEESGEEGNARWEPDNWDENEDTVSESGGGDDDDESAELRKLQNNLNSLPLSTLAKAQQSLSRKSSSASSHGQNKEEKLALMKSKLAQMQRNKGKTVAVPDADSHGFKSRTQESDEESDSGPETTSSTKRGSKHAPALMSTKKQVSRKRQVIEVSKPERRDPRFSSVSAGHANADLHSKSYSFLPDLLRQELSELKEAVTAAKKAEKNCPWAEKPMRTAERERLEVQMGQVRTKLVRTEKETMEREVLAKAKKEEREKRTQGKGAWFMKKGEKKDLLLKARFETLEKQGGKTAVKKLVEKKRKKLASKEKKSRPFAKGAEGMGQDIKRRRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRN9</accession>
    <name>A0ABR3BRN9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613797.1">
        <property type="nucleotide sequence ID" value="XM_066758395.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990770"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="113"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="258" mass="28011" checksum="7F1A2D78D863E32A" modified="2025-10-08" version="1">MNPSYFFPSGPSNYNSSSSSASASNSNSISPEPLHSAHYGQRQHPNQHQHPQQNYSHQHASMSEHGQGEYPTAPLQTGPMIAPHQDLHSFLESFWTRQMDMVEGETPDWKSYNLPLARIKKVMKSDEEVKMISAEAPIMFSKACEIFISELTCRAWLVAESHKRRTLQKSDVAAAIAYSDMFDFLIDIVPRDDGSAGGGGSGGGVGGSGTVTGAGSVVADEGVERDEDELEGDEGEGEAEGYDGQEEGDLYSEYVQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSA3</accession>
    <name>A0ABR3BSA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613750.1">
        <property type="nucleotide sequence ID" value="XM_066758348.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990723"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07569">
        <property type="entry name" value="DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF12">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="334" mass="37180" checksum="C7E1FB6CFAF28773" modified="2025-10-08" version="1">MARKITVAAAQVGAVHKDSQRSETLSRLIALLEEASKKGVQVLVYPETTFTTFFPRWKGLDDDPEELDRWFEHGDITDNPNISPLVSRAKDLGIDIVIGYGEKTDDSHYYNTCSYIHAGKEVSKYRKVHLPGNKEPYPDPEFIDQLEKRYFEPGDYGFKAFRVPNLAVTPEDGEAIAGMMICNDRRWAESWRCLGLQGVELVCLGYNTSTWAPGLFGHTKDADPEAIKAQSEFQHLLVMQAHSYTNATFSIAAARAGFDDGKFGLIGCSCIVHPEGHIIAQSKTMDDELVVATIDLDDAKIGKQKVFNFGLHRQPHQYSIITQQAGVVVPPCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSB6</accession>
    <name>A0ABR3BSB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613846.1">
        <property type="nucleotide sequence ID" value="XM_066758444.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990819"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="375" mass="40993" checksum="0A9E40B652325750" modified="2025-10-08" version="1">MPNTIAYFDITIANEPAGRLIFELFDDVVPKTVNNFKHLCIGDKTNEAGVKLAYAGSSFHRCIKGFMLQGGDFTRGDGTGGESIYGEKFEDENFQLKHDKPMLLSMANAGPGMNGSQFFITTVPTPHLDGKHVVFGRVMSNRSLVRRIENIPTTSDRPNQPVTISSAGVLSPEQVTQLEAERQAKQANSEGGDIWEDWPQDEEGVDAEKPDEAVAVAGKLKEVGTNEFKAGNFAVALDKYQKALRYLDVHPVLPDDSPAELVESFRSLRLPLLTNAALCALKLPVSPNTSSLVVSLTSRALTLPNLSPSEKGKALYRRAQAYVLKKDDEAAEKDLKGALECVPGDAGVVRLLKDVEAKKKARKEKERQAFAKMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSB7</accession>
    <name>A0ABR3BSB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103882</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613765.1">
        <property type="nucleotide sequence ID" value="XM_066758363.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990738"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="140"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="343"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="493"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0247804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="539" mass="57858" checksum="636B3E0F9B2BA7FD" modified="2025-10-08" version="1">MSYGGGYGGGGYGGGYGGGGGGYGGGGGGYGGGYGGGGGYGGGFGGDRMGNLGQGLQNIDWQNQSLAKFEKNFYVQDPRVTARSDAEVEAFRAEKEMKIQGKNVPRPITTFEEAGFPDYIMSEIRRMGFTAPSSIQCQAWPMALSGRDVVAIAETGSGKTISFCLPAMVHINAQPLLAPGDGPIVLILAPTRELAVQIQTEATKFGQSSRIRNTAIYGGAPKGPQIRDLQRGVEICVATPGRLIDMLETGKTNLKRVTYLVMDEADRMLDMGFEPQIRKIVSQIRPDRQTLLFSATWPKEVQRLAMDFLHDFIQVNIGSLDLTANHNVAQHVEVCTDFDKRSKLLGHLEKISQENGKVLIFVATKRVADDLTKFLRMDGWPALAIHGDKQQAERDWVLAEFKSGRSPIMLATDVASRGLDVRDIGYVINYDFPNNCEDYIHRIGRTGRAGRKGTSYTYFTMDNSKSARELVQILRESKADIPPELEEMAMYGGRGGGGRGRGGRGGGRGGYGGGGRGGYSSGANSYGGGGGGGGYSSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSE4</accession>
    <name>A0ABR3BSE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">6-phosphogluconate dehydrogenase NADP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613753.1">
        <property type="nucleotide sequence ID" value="XM_066758351.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990726"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="279" mass="30393" checksum="347A960DBC315F62" modified="2025-10-08" version="1">MLIPLRKMSFQIGYVGLGNMGTPIFLNLARHAKANGWPAPCAWNIDQSRYDEIRAHNDHLYLCQQLGEVVKRSNVVFTCLLNDPVAEEVYQRLFATVDAKAKIIFVDQSSLKPKTSIKLEAAAHKVGASYLSAPVFGRPDAAKSANLVQLLGGDAKAKETVKPIFVPAVAKRVVDAGDEVAKGDFFPLYPYITYGDNISKGEFNGVGGFRLEAGLKDARNALSLGADFGRPVSMPTIELAKKHLERAEELCGNDVDWSALAIALREQAGLEPFRAGHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSN7</accession>
    <name>A0ABR3BSN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614164.1">
        <property type="nucleotide sequence ID" value="XM_066757780.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990136"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046617271" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0249977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="141" mass="15755" checksum="04FE8942217EEFCD" modified="2025-10-08" version="1">MYHPKALVIALLFSLSLILASKSSEQLQIGVKYVPEECPIKSRKGDRLSMHYTGTLAKDGSKFDSSLDRNRPFEFTLGAGQVIKGWDQGLLDMCISEKRKLTIPPHLAYGERGHPPVIPPQSTLVFEVELLGIKNRHVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTG0</accession>
    <name>A0ABR3BTG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell polarity protein mor2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614427.1">
        <property type="nucleotide sequence ID" value="XM_066756958.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989270"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="385"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1500"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1751"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="1982"/>
            <end position="2229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2364" mass="259209" checksum="66ADD46D3C1D38B7" modified="2025-10-08" version="1">MEEIVIPNLEDDEDDFLPALARPMFGSASSTSSLPDTGSYGHRTNLSSDSSYPAKFGATTPTRPALPKASASFSANTGHGFGQDARLGKFSNASSSSLVTSGTSISSSLALTPGKRPGFASKSSLASFKNAFKSSNAMMPPIPMFDSKSGAPGYPALKNPFSRFDSPVSPKSAGFKISSKGKTPSTSSPAMARYQSSDGGRKYSIASSHRSQGGRSMTSQGSSNFRADDYPMPALPPISIRQTPSRIGRHGSDTGSFVTGRRNGSADLDGLYLAATPAEEALRVVFKEFREVASSKVHKICARPLNSHPSLSSFLDTGVDPQFDSIITSLSQCATCHARRVIDLLMSWCRDYCGNIGASEVRTHLDRSIGLQIKVEEAAAILQARKSLASRFIMNRAMIELLKIIPKDSLDQELGMTLEQNAFNAYRSEKLEDVMQFPHRKAVSQLQVELLGQLSKTRFLTVSDRFIRELSKYATNQQPTKESEAKIEHLLKGMRQLQLKVYPEEELELSAEFLQSLSTFFATAHGQSLKIAYAETLSYLLHSVVETATAEVNHPIWSQAIAVILERTVGMVSKARYWGAAFPLMVTAMGVSPREGFMQQWQGVIDAILAKFKDRNLRPIAMGALIRLLWIYLHRCSESSTSTRKRLEPLIRILFHSSPMSPLYPPDIPIEAFISVLHYVMTRQIEYGEELVSDFLGGRAVAGEGGADRATALVRAIDYTLRAIELEKAAIWPQYPDFNKFRLEAYESSGEVLPFETESKAEVRDLLKKCGPSFLNTLVDCDDDVRHLLLSNDAVTLSGHTSSNTMVNPVDSITVKHGDVYVSYPARFAVRLRLMGAIIDTLPRCLPSDAKWGDLASILSRATFSVDPKLCASAANALKRISQDPQKCLLLVTTYRGFVFETRHVFKDTFIGARLFESQFERVIRLWLDMLQSLVGHQRVAEAHAQADEGEPDIPSIESSQIAQIEGCALFLLCSSSATLRKLAGQILVAARNLESQQRMPSAAFRYSRISPDRSAMSRVLDSYEHAFSEADIVALEQIPWLSQPDRLRLETLVGTLKKSGNKLIQRIAESEHSRDGTLWLAVLPYFIGKVAETLPSAAHELRSVVGGLVLRLQAHVAVVAGGAMRGTPSRNGGGYASTKTSSDVAVLAEHWRAYHSVLCVTLSPTNPNGPPPSTPPIQRATAKEMIILNQDTINSPGLFTYLTSLVGWEDPRFKDAAVHALGSIRQGMLRPLAEQLLTLARRLMDGTKVGGTSREGTTKKTPNANIWTALAHIFRLISPLVLDTKSSSHLANLSSMIGFVKLTYSLLSDRSVKEDFDLQNLRRSFCVVVENLTNALGKLDSSHRFLGEDMRGAIFKLCTEWCLVGRRPDVAKARESQMLQAAAGGYKGEKDKATYLDNLQNKTKLLSMAAAEAMAGLCQGKLISVSDSSPAQQASEHIVEPLLVLRWIRGMFGSGNASHNVTGKRALFALLKYNWQCERLLDEVLHQSFGEGEQFPLDSSFFGVVADLLSEGLITLPIEQIACLTLSKLGHPVSHIRQRAFQLIEELFVLPEHQIAASKMLPSVGSFSPVVYRKAQTILSSQLAAIYAESSFEFLSECTVRLSQLEAPRRQATLCIISPWAQHLEVLSDASELEAEQVTRQLKALHNLVYLGMRFGDDYIEEVKAIILSFVGSDSVQSENTTALVKFLFEQGGKRRSPDFVEHAQRIIACLASSPAADSIFEDICNFVEPNAMVALPDADVPPSPMSSLANLDTIMSAPSTKSQTFSTGQLALIFASELLPHRLGDVDLPQKLPALLHAALIQCDHPSSALREQAQIVLFQVLRAWICDFSRVPSKDAHAIWSSAEHQVTSLARNRNTFWQSDDMGGTDVAFLAPIKMTTLVVKILGILLPLQPEVRQLWGELALSWATTCPMRHLACRSFQVLRILSPKINPRMVSDTLARLSSTIGSSSPEIQTFNSEVLRTFASIVQSLSPAEALAYPQIFWCSLACLTTPYETEFSEVVELLSHVLDKTNLSDPAVVQLLNSYRPADWVGPAPYLQSLLLVGLRSSKTAFLTFDLIRRLTSASHNELIDAPNDRLIHGFIAALPWMLHSTDLGEPNEELAGMALDLAEIADQQGQASFSRLLTSFAKVRFRSKDDFIRQAASLLRDYMPTHALDIVTLLLGFVLNTYDWMREKSMQVLKLVLQSPEARVSLQAHGNELLQPLLRLLTTKHASQALDVLDMPMTATAIAAGDNSTMLPGYGEVFGVVEESGWSVPKAKELSTLTRENVRAVFNTCATETRAASARFSVVQFADMRSFGPNASQVSLDIPASPHTNESVVMDNASIGDLVGALHNLGHFFEDEDGAAGAAGSTSPPLALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTS7</accession>
    <name>A0ABR3BTS7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614546.1">
        <property type="nucleotide sequence ID" value="XM_066757077.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989389"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="216" mass="24823" checksum="2655BCF7BD026DEB" modified="2025-10-08" version="1">MGRRPARCYRYCKNKPYPKSRYNRGVPDPKIRIYDLGRKKASVDDFPFCCHLVSDEYEQLSSEALEAARICANKYIVKNAGKEAFHMRVRVHPFHVIRINKMLSCAGADRLQQGMRGAWGKPYGSVARVNIGQVIMSIRCRDSNKAIIMEALRRARYKFPGRQKIIVSKKWGFTPLDRAEYEALKANKQVINDGAYVQFLKPKGPLLQNLRTAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU15</accession>
    <name>A0ABR3BU15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614624.1">
        <property type="nucleotide sequence ID" value="XM_066757155.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989467"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046067619" description="DUF7729 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="3">
        <location>
            <begin position="100"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="353" mass="37509" checksum="2DB0688E26E32859" modified="2025-10-08" version="1">MRFNWLLEITVCILLSLADPAHSHAHGSGHSLKASRHRHHLQPHALLSPKQGHGHSTLLLPRSNSTAISSNATDSDSVESSADATLPTRPCTVITAPPSPMPTPLDLSISTSLSSSCMLYLTSLVSSETFLYCLPFSLLLTTSTAYSSIVAKALASHNYTTLNDLVTYTSSPQPSIDQCETYMSGVMTALASKSNCASDISKNVPVAVKTKWGVGNYRVMREAESLVNEDTGVFCYIEAVASERPDDLYLWGLPGGISLPSSSMPTCTKCSASLLKIYGSYVSNTTTLNSTVINAAVKKVNEACGSSFVNFGKDTQVSGDLSHVAVGFIAGLKGAVAFASIMAWILIVHIDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUC1</accession>
    <name>A0ABR3BUC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="3">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614726.1">
        <property type="nucleotide sequence ID" value="XM_066757257.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989573"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="68"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="265" mass="29913" checksum="E8D22541D4C3B4F7" modified="2025-10-08" version="1">MSTTVVETVTTPAATFTTAVNDINLDSYDEEQVRLMEERCILVTPEDKVYGEGSKKVCHLMSNINGGLLHRAFSVFLFRPTDGRLLLQKRADEKITFPSMWTNTCCSHPLSIKAELVEKDQAGVKAAAIRKLPQELGIPESQLKPEDFHFLTRIHYLAPSNGVWGEHEIDYILFSTLNVDLDLNPNEVSDAKYVSKSELEAMFTDPSNSFTPWFKLIARDLLFPWWDEMLAKSRSAGWDEESGVGEVRADVLANGPKMNELIRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUC4</accession>
    <name>A0ABR3BUC4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614721.1">
        <property type="nucleotide sequence ID" value="XM_066757252.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989568"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="82"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="287" mass="33224" checksum="6CB306FF808CE7FE" modified="2025-10-08" version="1">MSQPESSVAPPRDSYDERAASPPPRDYSEDKYSTRPPPAKYDDEFRDDSYSVKGGDTYRNDRPAFEAPRRPAQAPPPVNPNPVLGVFGLSIRTRERDLEDEFMRYGDVEKVVIVYDQRTDRSRGFGFITMRTTEDAARCIEKLNGLSLHGRNIRVDYSATQKPHSSTPGQYMGAKRPIRDDSYGRGRYDDRRGGYGDRRHDDRRDYYGSSSSRYDDRDSSYRDSYSSRRTGDPYEGRSRRDDYGYDKYDKHDKYADYDYDKRSSRRSRYSASPARSTAAPAPEVPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUD4</accession>
    <name>A0ABR3BUD4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614738.1">
        <property type="nucleotide sequence ID" value="XM_066757269.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989585"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="178" mass="20150" checksum="414652A96180E77A" modified="2025-10-08" version="1">MWKDKKGNVMTGVGDTCRVKKLIIAIDVTITYTPTSRRYETRIVEFEDLVEYRARSSTDGSKTYTIRGTDILSPASNGATFDWKGKGLLFFVHSHWEVLGYGKDVEQGLEWAVTYFSKTLFTPAGIDIYIRTIPFSSKPQNFTAREALLQRLINEAQNNDVDSIRNLAKQGFRVPGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUE3</accession>
    <name>A0ABR3BUE3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614244.1">
        <property type="nucleotide sequence ID" value="XM_066757860.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990218"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="5">
        <location>
            <begin position="94"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="280" mass="30437" checksum="B7C18B4755A99FC8" modified="2025-10-08" version="1">MSSIPGTVKHSFRTATRSTHIRPAFAASCRCLTRSNNAAAADTQRRTFFSLPDLTKIASLVPGQGQEDSSESARAQGVEIDGEVQRFHARKILPYSQVQLYSLVSDVPSYASFIPFCKSSTVLAPSSPDFSSTREWVGWKPEDKPFEVLAELAVGFGGLEERYVSKVVGKPYESVVATASNQTPMFKTLTTSWTFSPASSISPHPSFGSPSSNSSNSRIPNSTSPADPTQGPSLLTIDLAFSFINPLHRIASQAVLPKVAEKMVEAFEERCLKVWGRAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUG6</accession>
    <name>A0ABR3BUG6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614686.1">
        <property type="nucleotide sequence ID" value="XM_066757217.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989533"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="181"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="565"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="909" mass="102094" checksum="58D12B5D73029CA8" modified="2025-10-08" version="1">MSSSRPATSLTVPFTPKPRKRTSSSRLTFTDKELNQFAGTLASVRKVRPGAILEELEQSGEGSGILHRHESFVHREKTETQKRSTSARAMGNERDRSHFHTRSSSSASIARREYNPSSFLRATSGSEDLVLESVHRGREEVNEPAKKESFVKNLTPVTELSEERRLLDDVPLEVQEAWICEDLLFVLQGVEGALIRYDEGYDPFDEEQRLKGAKWKVNPLLDPSLLSLVKRLLPLASFFTAVEASMELRTAPEYGMVSHALCSGIRAMLKEFRVLTAQLESLFLSSPTFTLQTLYLHLHPTLHTMSLLASLCHALEADQAEQGTDDLSDDDDGLGGMAEELGLGGAGLKGLMKNLKAREGLIGDGGDVLGGEVLGIICEREATMSGDPTASTLHSSLLLHASQPYCKMLIQWIATGHLSDPFDEFMVKESGHITKGVLESDYTDEYWERRYTLRDGAIPGSSKVSARNSTPSISAGVPSPRQGTNRLPGGACIPQFLQPWKHKILLAGKYLNVIRECGIEVKKPSEVDEKEMRTMNDPNFYKRIEDAYIYANKTLLKLMVEEQELIPHLRSMKHFFFLNQSDFLTNFLDLAASELRKPAKSASIVKLQSLLDLAVRNPSSSSSNDLYKDDLKVVMQSQGLYDWLLKIVSKTGSLTEEGELDFALGDIHEEGNRREKERPLIAIDALAFDYSVKFPLSLIISRKTIARYQLIFRFLLHLHHLESALSAMWLEHKSPSWRDNLGNEDIERWKARIFSLRTRMLAFVRQVLAFATGEVLEPNWKALEEKLSKVQTVDQLLRDHVDFLDTCLKQCMLTTSKLLNIYAKLMTTISVFVSYQSSLNSALNKFLVDPVAESDPAKCKLRWTALSKFEINFNHHAKLHLDAVTYNAGSENVALLALVTRLHQITLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUX1</accession>
    <name>A0ABR3BUX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Chitin synthase</fullName>
            <ecNumber evidence="2 13">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_103201</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 13"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614085.1">
        <property type="nucleotide sequence ID" value="XM_066757701.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990057"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="809"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="878"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="15">
        <location>
            <begin position="140"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0249898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="914" mass="102872" checksum="568DC4014B40EBE6" modified="2025-10-08" version="1">MVHHDPFTDSQDSSFTPSPNPSTAYRPNTPYQQSGRYQPYYPPQLPYYQGQQQGHQYDHTGDVGYGGHNRRQGSWAAVSNEDNEELRPLTTGPSSSSTFLTTDPYLSGGPDLPLSSSSASICSAGADFLRRQTCPRRGATIKRIKLTNGNFIADYAVPGPVSSSVEAKWLSDKVSNEFSHMRYTAATCDPDDFTPENGWKLKTTSYNRETELLIAITSYNEDKILYARTLHNVMLNIRDICNTKASKFWRRSAEEGCPGWQKIVVALVADGLDPMDKEVLDVLQTIGVFQDGILKKEVDGKKTAAHIFEYTTQLSIDATPQLVQPHPGDPNNLVPVQIIFVLKQENSKKINSHRWLFNALGRQLQPEICVLLDAGTKPGHKAIYHLWEAFYNNQNLGAQNFEYKMSNILDKPLESSFGYVSVLPGAFSAYRYKAIQGRPLTQYFHGDATLAARLGKKGIYGMGIFTKNMFLAEDRILCFELVAKAGEKWVLQYVKPSKAETDVPEQAAELISQRRRWLNGSFAASVYSVFHFFRLYRSGHGPIRMLFLHIQAIYNIFSLVFSWFALANLWLTFSIIIQLLPESANINLFGTADVTHWANLVFTWVYLAFLMLQLVLALGNRPKGEKGLYILTLWVYAFLSLYLIVCSIILSVVAFKGALRDGESIGAKLGNLFNSTNGVLVAAIMSTIGIYLIASFLYRDPWHMFSSFPQYMLLAPSFTNVLNVYAFCNLHDVSWGTKGSDRAEALPAISSSKEKDGDTAVVEEQQRSQRELDESFRQVVQRAVAPYKPEEAEEKPNLDDQNRTFRTRLVVVWLLSNAALAISIQTLNGLDTTKQLVEACLPSSYNVYNGTVIVPTNGTCISQALEHDGEKLQDKQQIYFQAILWATFGLSMVRFIGCVFYWVMRQMGRCWRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV01</accession>
    <name>A0ABR3BV01_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614946.1">
        <property type="nucleotide sequence ID" value="XM_066757477.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989831"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="98"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="291" mass="33064" checksum="D41F0E8CBA06924B" modified="2025-10-08" version="1">MSASDPLSGHPGHLSASQETALQKFREELTTEELIPADWKALVQRIGYNRFDDQTLLRFLRARKFDLPKAKLMWTNNEKWRKQFGADEIAANGFDYPEQSQVVKYYPQFYHKTDNDGRPVYIEQLGKLDINKLYAITSQDRQLKRLVSEYEKFLRDRLPASSKMTGHLVETSCTILDLYNAGISTFYKVKDYVNAASSIGQNNYVSTDLMGHMFIINAPYLFSTVWSLIKPWLDEATVRKIHILGKNYQPELLQYIPAENLPADLGGTCKCPGGCEMSDAGPWNVGTTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV06</accession>
    <name>A0ABR3BV06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102976</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614947.1">
        <property type="nucleotide sequence ID" value="XM_066757478.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989832"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="252"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="466" mass="50720" checksum="280AFDE88E121489" modified="2025-10-08" version="1">MSNEKQPQYWEATAPAIEAQSSSQAKSPPDRPHDVNYSPSQSLPQVPDSAQPPNGSHPSPSVTSTYSSMMLPPLRMSHDARNSVPSPLSSGHPQMYSLRPPPHNDSPNQMQPEFYYTYPVPYPLRPPAYNGHMPTHSGSSSNGPPEIFTPVSANINSYGFSYSGQGTIQPSLFSPWQGQDRRQPDAPSSNFGTSGERKGSRGSSTTTGERWDRPSPNHGGTASPLTERSTSVDEKDPKEIRYTTDAEVKQTSQMKRQCFNCTSRNPPSWRKSVLHPGKILCNKCGIFERTHHRPRPPQNDDQKLRKASTLSNSIHRREAPPSIPMSASLTYPPMYPSPDPLLAPAGYLRRSATHQPTLESPQPSPLNNAIISPNLSSAGDSNAMSGGATRHYGHQHSASSPYAQAYASRRGYVPTARGMMSSPSMIPSAFSGAMEPVMTPTAGHNQLESQPHAVNGERQHQQGQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVH4</accession>
    <name>A0ABR3BVH4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614860.1">
        <property type="nucleotide sequence ID" value="XM_066757391.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989712"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="138" mass="15334" checksum="32A93E66479BED91" modified="2025-10-08" version="1">MEAVSRSKPKSEISVLHLFFAVNRSDTSTEQPTTNSGLETSLPLARPRSPVLSLFSPPVYRVTTTLFLPISLLSTLSSTHSTFTTVSSGTPWSFPRRLPRASSFHIHRHHSILIGHMLVDHIALGRSLYCFSPFLDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVM3</accession>
    <name>A0ABR3BVM3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614905.1">
        <property type="nucleotide sequence ID" value="XM_066757436.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989757"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="537"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="724"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="782" mass="85394" checksum="8941AFD01E2FE7C2" modified="2025-10-08" version="1">MSPDIKHSFRPQVVKSRVKNYFGYTETTPETISVFDWAKSRTPALGPGIKSYILSLFPFIQWVPRYNLTWLFGDLVAGITVGMVLVPQSLSYAKIAELEPQYGLYSSFIGVLTYAFFATSKDVSIGPVAVMSLETGNIILSVQDKYGDLYSKPVIATALAFICGFVVLGIGLLRLGWLVEFIPQPAVSGFMTGSALNIAAGQFPAVFGLSKKFNTRDATYKVIINTLKFLPQASLDTAFGMTALATLYGIKWGFTWLGKRYPRYGRITFFCQSLRHAFVIIIWTVISWRVNVHAAKPRISLVGSVPSGLQHVGRPFIDGQLLSAIGPHIPVATIILLLEHISIAKSFGRLNGYKINPNQELIAIGVNNTIGTLFSAYPSTGSFSRSALKSKAGVRTPAAGLATGVVVIVALYAVAPAFYWIPNAALSALIIHAVADLVASPKHSYSFWRVAPIEYVIFVGAVVWSVFYTIESGIYWSLATSVVLLLLRIARPKGHFLGRVRIKPEAGNTLEHIRDVYVPLDEESSREDVKVENPPAGVIIYRFEESFLYPNASYINDRLIEQAKKVTRRGGDYSKVSAGDRPWNDPGPSKKNAAAVLEADMAKPILKAVILDFAAVANLDTTGVQNLIDTKTEMEKWADGPVEFHFCGILSPWIRRALIAGGFGQGRTKEGTALEVAPAVIENLENAASPGMERERYNEHEVSFIHEIVQPSAFTSAGTSFTEVEKGMGSGASTPSTQVEGVNDRRPSGASGKTIPLLDRSTPFFHFDLADALHSLNLPENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVN7</accession>
    <name>A0ABR3BVN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab proteins geranylgeranyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615153.1">
        <property type="nucleotide sequence ID" value="XM_066756376.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988683"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017230">
        <property type="entry name" value="Mrs6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037514">
        <property type="entry name" value="Rab_ger_ger_transf_A_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="500" mass="54448" checksum="70AE5DDCAF5DADE8" modified="2025-10-08" version="1">MSNTELESDAYDVVIIGTGIAESIAAAALAKAGKTVLHLDPNEYYGGEQASLTLDELIDWSTKHVESSSGAVSYTHASTSALTPTLQNDRRRYALSLFPAILPSRGPLIDVLISSDVSKYVSFKLLDSVNIWDEGCAGARKVPGSKEEIFKDKSVSLMDKRKLMKFFMFAAGEFEHSDILRGKETQPLSDFLQDSFALPTSLALSITYAIAHCTSPEDQTLHALMKTRRYLKSLGRYGSSAFLVGQYGGSGEIAQGFCRGCAVYGGIYVLGQFGKPSLINANDENVTLKLPCHPRPVTAKYLISSSNHLPSSLLIPESEPSISNISAHGIAITSSIPEILQRKSPFTDDENERRQIPEENDDTGLVVFPPENGNPTVRCLINGEGTGSCPSKQYILYLSCPTSTASLPSDLLKPYLQRITSESLFESYYISSRTTSNYSASSPKVIIVTPFYGDDLITEGLDWEANEAEKAYYSVVGQDGVPFFGVTEGETDEMGIFEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVR4</accession>
    <name>A0ABR3BVR4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-methylcrotonyl-CoA carboxylase alpha subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101859</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615187.1">
        <property type="nucleotide sequence ID" value="XM_066756410.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988717"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="3"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="165"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="626"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="77307" checksum="FDC3056634D34124" modified="2025-10-08" version="1">MRPIRGILINRGALAVPRYIKHHRLTRAHHMVGANRTLYGAQYSTIAQQHDNMTQLVNSNPEQRVGKRPFKKILIANREADRNCQHVAMADEAYLIGPSPSSESYLKMDKILDIAKLTGAEAIHPGYGFLSESSDFAEKVRDAGLIFIGPSAEAIKSMGSKRESKEIMVAAGVPCVPGYHGADQSQAALLKGSQQTGYPLIIKPTHGGGGKGMRIVRDPSTLQDELLSAQREALKSFGNDEVLLERWLEKPRHVEVQVFGDHFGNCVALWERDCSVQRRHQKIIEEAPAPGLSPALKQGFAEKACSVGAGTVEFIMDAETGEHFFMEMNTRLQVEHPVTEMITGLDLVEWQLSIAAGNPLPYTQDKIPCIGHAFEARIYAEKPESNFLPDTGKLFHVRPPINTPHRLETGFQEGDEISSHYDPMIAKLVVHGKDRPQALSLLRSALAEYQIVGPSTNIEFLKSVVEHDQFAGGPVETSFIPSHHDELFPQRVVPQDILAQAAVFLVLRAESGQKALTSAGPWASLVHRRFSDMPSFSYRLDSEQVTVNPIESGYHVTIAGPDVYSQLIQSSATSSIDFIAQVGPKKIRSTIIPIVVNGLEKLHIFSSSSHYIITHHPSLLEGTDGPQSLSSSGMGTLVSPMPATVIEVKVKKGDTVKENQVLCVLESMKMEINLRAERDGIVGEVRAEKGKGVEEGEILVLLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW27</accession>
    <name>A0ABR3BW27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614829.1">
        <property type="nucleotide sequence ID" value="XM_066757360.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989681"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="945"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1008"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="479"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="805"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1038"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="816"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="859"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1095" mass="118371" checksum="774CEF778373C389" modified="2025-10-08" version="1">MADPASPPSFDAIFAQQPVRRSSSTSTSSFGNYTYSALQQHQQFNSETPLVDEPQSLSEQPRKQQRDQSRDGNNKRYIEMMSGLADGYNGINGKRQESLRKESLPFNPQEDSTLIATAPRRGERSGLSRNGYSSPIGDIMFGPEQVIRNQPQQPSQHWGGEGRMSEQSIHYASVQQPQYSSFQSSQPSTDSAGMSYLPRGTTNSMNDTVLPNQISPYLNHEVASEDQPQQQQQQQQQQQQQRGEWGQEFIGVEQQQQYDQGEGQSNGMEDMLTMGDESPFENELQRVISNTSHPSQYPSRTSSPFPQQSQSNMVPPPTGNHTRTESFPTSRSPSPFAPQQAPQTEAPSHVVSPPTIAQPTYPRASSSPHTNPNSPFFNKPQSPPALIIPNSPVLPSIVTQSTANDHSKGLNQPHTRHTSNGAGGLFPPSNPALEHLTGMAGISPIAPNADGPMICIQPSTPISGLKEGRGLFDAALRRAGAMGAAQRQGSQGQGESQEDRQQHGFNVPPPQSHPLPRSSSSDPVNQGVEMSEMDFAAQMQSYGQQGWAGDTLRIAGPSRPRAKSDSIIPSPTADSFDRQAFFAFIGAGNPHPPPSSVEMQSGYVDVSEQWRNTVSAWKAGLGEGELNGQPTLDPRLLPGRESNEAVYQQLLMHQQTGQLPRLDPDQLHQLAQLEAQRIRLSLDTGVAPPKYGPGEISPTSMAFYQSIGLYPHAAPELSGTVSAPWSQTAFGQIPGPSLVGHPATAGPAQQHFLTPVPSHATARRRSFGGGEHPAMGAGTPGYGMEFSSPFADKPAGQVRGVSMGHRRAARSEDFGRGGTGWGVGAGGSTAEFLQSITGDDGSLLPPSNRSRAMSHSRHSSTSSIRSVSPALSISSQGSSFSHHSPRMDMPDGMYPGHPIIAPATPLQVSGPYEEQQVPAKVAKMKVTSVATEVASTNRRTNSGIFKCPVPGCGSTFTRHFNLKGHLRSHNDERPFKCLYEGCPKAVVGFARQHDCKRHMLLHEGLRLFECEGCGKKFARLDALTRHHKSEQGQECAITHPLPTNFDGSPMSESQYKTYKGIKSTPEGSGRRLSSTASGSEGGKKRSKKSETSEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW31</accession>
    <name>A0ABR3BW31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615051.1">
        <property type="nucleotide sequence ID" value="XM_066756274.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988578"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1383"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="656"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="964"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1241"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1402" mass="158344" checksum="BF2E62955AD90A19" modified="2025-10-08" version="1">MDIFSRLNPFHRPNSAMSRNTPTPFSVGARPSSSLENGNDYPRPEATPNPSLGVYCHPGGQLSHHMPACYGETPTMPKDNYHRSQSLLRNFAHHSSLSALTSKSTGGKKKGKKRKGIHLMPDSSHPYGDGGDGSDAKDSELQRRLIPTFGIGKLKKGTLKPSKSLPRDLRLSEDFQLPNDLPPLPSSTKHDVLNKSQAGMVTFRPGHVSPFKSQRTCLRGNTVTPTPEITLYHDCSGTPETVKLRMRFDLDWTSTYSGSPSRRRHNSFDERVSHVDPLTPRAQSIRHHSSPQKASSSTTLHEFTYLQTQQHPHPVPRIQEERIFAHSLYADSTTFFGPDDILPITESGNTIFNEEPKPLDMFKRDKKLNEGKLVGSETDLLKGISVDGRKRYKDAEGFDLCASPSASSESTYNSHFAHHLSPKRSSPTHRRAESSPSPGRKPRDTFSKAAKRSSSPFEIKLSPQVTRRMSLDAFGTPTDLLFNSHNKDDKIEEITDVGESYESRDWHQAEEAKAEKPLSQTYDTNQDEFFSSDEQPLATFRGTELSTIMESSCSRGNESQCMSSEIGRGSPMQSHGSLPRPSWDPFSNNEWQQPFTPKLTADGLPMPNSMSPASPLLHKKYTSAPPLVGVSPRLLDAHLEHSQSLKDQISASSVIMEVLKSEVAEMKKRLGDEARERDELIEFAEGRVMDLEEAQRRCDAQDQALEQLRQAMTAKEHMVEELREAKLFYEECCDSLERENDALLATKEETIQVCIEMETENDELKSELSKIQDENDKLRRDKKEAEVNIQALQTEMRFIKSKMSNMEDVEGLLRDTETEVLELRGGQESLLEIEKQLENRDVRMAERDRTIQVLRKSLDSARWECLNRVEAVTEELMASVQVISDKEEIVSDLTSKLSTHEEYSQLTKLALTAKEEEVNELTSKIKSILDKQREDEEMLLKLRNQLQTLGAESKARDSEANERLLMYAEEMEALSEERKDLRMKVSDLSVQAISASSECDKHKLVLIQKEQTINELTEKLRLIEFESDERHFESQEAIHRLKSQIEEQSKNAAEIEMGSVQTSRLLASYEEEKRLWEEEKEELYERLTQHMEETGNVENLQAEIDGLFFQLQVVQDECEVHKASAAQKSDLIRSRDAELAKLRHTIKEIEKSTAEARTAMDRRAKGYEREFANLHEQVEELKQKLSHNNSALRSAVLEAESGKVLSQDTKWRVDRYLTEIDKLKLGETKLTSHVEQLRMELAMDEFKRIELERKVTKLEQEKELLNVALESKQTEVALLQRKEKHRSVASPSFSSAKAFHSSQLSVSTSRILATPTSGTGINNAPPNFRLATSIGKDMTGSKLNAASRLPLGASSRDNTVSDGSRVIPTKATREAEYARKKVARTSLPTLARPHSAAGRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWB9</accession>
    <name>A0ABR3BWB9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA repair and recombination protein RAD54B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615403.1">
        <property type="nucleotide sequence ID" value="XM_066756626.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988933"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="349"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="677"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="881"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="981"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1019"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1063" mass="118743" checksum="3296F2F4A648E3AE" modified="2025-10-08" version="1">MTISMARPRRSLGAIIDSIPSQQEYVPDSCSENSDSDSGRDAPIPTLKPIPLTPLPSRPTRSTHEQGPESITTVKGKEREDAGAVFGDGKKDKKVHGTVDTLSMPVLYFAVQWRKPQFKKHKTWDGDANIKVEGNRIVMLDEDGNQMATTNVGDKVIRPEAEFKIGGYEVMVDHALQQDQFKASTSILNRPKVISTIKSSGYRPASFTKAFRPPIQKEKLTSTKPSTIEAVEDEHRQSPISSLPKRSIPTPAAAQRAVAASSFYTKQSSKPYSERIVLGEKSNKERLEWGGALFNPHAEGAVVMPRPAEKLAKLKGTTIVDVVIDPILGNLLREHQKEGVKFMYSCVMGMTGAEGEGCILADEMGLGKTLQTIALIYTMLKQSPFANQTSIIGKAIIVCPVTLVDNWRKEFKKWVDRRVNVLVADGTDYRVSSFVNNKHQHVLIIGYERLRKVVKELASCIPPIDLIVCDEGHRLKSKDNKTTKMFDMLKTQRRIILSGTPVQNDLGEYWAMVDFACPGVLGKYSAFAKHYEKPILKSRTPNCSTKDVELGRERANDLAKLSKEFVLRRTAAVLEHYLPPKYEYVIFVAPSLLQLRVLSNLLDPSIVGSFIRGHGAQSLALIDLMRKISNSPMLLKRKDDELARADDDLGSATSAAISAIPGDTNINDVTASGKMLLLDKMLHSIFQSTEEKVVVVSNWTSTLDLIQGLCKLKRYNYLRLDGSTPPKQRQELVDRFNKDKERQGSFVFLLSAKAGGVGLNLIGGSRLILFDSDWNPSTDLQAMARIHRDGQKRPVYIYRFLTTNAIDEKIYQRQITKTGLSDQMMDQKHSEKQTSKDSFSAAELRDIFTLNVRTDGCQTHDLLGCQCTEMPVGKLRDTVEVEQGSEHLPDNASGESDSDPNDYPTFVSANKYDPEPTPKMHRKAIKEQKNKLAALKRWAHFDPFQLASFRGIQDSLLYNVLFDSWETDGVPLSENIRAYGTPGFEGPYERDEDDPDSDNEALVPKKRKFGMVQTTAALKKTRTTDEEDTRFNQRRRNLKSIAESGGTGRVTFVFEKISKSTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWP8</accession>
    <name>A0ABR3BWP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sld7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615529.1">
        <property type="nucleotide sequence ID" value="XM_066756752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989059"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="65253" checksum="ADE8A72E3D800945" modified="2025-10-08" version="1">MAVFHPGPSPSRNPFARPNSVPQGDSFSKSTILPSPSHKRPTLTAIVNDVDKSLGDGIMATPSDKKVISTNGTPKSSWRLLWRGGLELGKEGWRLEGITFFALLSFSAPTPTATPFNPFSFPTPPPSFSPVPSSPFHSLPGGTVDICLSLESMKGRKFLQVRGLVPLPEDELLEGESEEDSTGGVQVAIAPEAYLLVAYFTGLLCREGKLSNSGRTLCAVVIGLGDEEVDATPKSTILIYGQLRNQSTTSSDEDKTRQGALRLLVGRKRLPRPPDNEKRIRPGEPLPRAPLFLPPENKKPFRPFARTLSHSSSTSIYAPPPSASAVVPLSRPGPAPISGRTPGRRGEKRARQNGNDEQRKRRTGKVTGAPEKIDLPFDVADQSKEDGERRERSAVPSEHSRLAASTSQMSIVASEGLPEEEEDIFGLRPASIAPSMSRVPSAGGRSSVAGDKVVEGEDNFEEIAGVGNAKRARVPQQVLDNKASIRKQTLLLLEERGVSRTNDLFKEIFGITTKGVYFAFRDRLDEATLSKPDIHRVILGHLDMYLPTSPSRQTHLGKTIFEDEKPSSESAGREVCIIGEQSLYLQGYYDGRVKLEPVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWR9</accession>
    <name>A0ABR3BWR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615550.1">
        <property type="nucleotide sequence ID" value="XM_066756773.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989080"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="16"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="192" mass="19998" checksum="504A2C7485A70D5E" modified="2025-10-08" version="1">MAPVKKTAATPRKATTHPTFLSMIQECISQNKGDARKGVSRPTIKKFLADKYKLDMSSPANISNLSNAIKRGALKGQLTLPSGIAGRVKAGTKKPALVHKKSIIGKENVAPKKVVLAKKAASNETRKHAPKKASTANAAVKAVPAKKPAAKKTAPAVKKTSAPKKAHAAKEAVAAPEKAAPKKKALPKKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWZ9</accession>
    <name>A0ABR3BWZ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CipC protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615633.1">
        <property type="nucleotide sequence ID" value="XM_066756856.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989164"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12282" checksum="0584669C815E7B52" modified="2025-10-08" version="1">MGLFDFFNNDPSGRDEVYNLDPNNQQHKAKLSHELIGGAAGFEAMKAYENHVARNGKPPSHAMAKEILAGLAAAEVDKLFETKGLDGWDREEAKRHARAQAERALDQSGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX27</accession>
    <name>A0ABR3BX27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615661.1">
        <property type="nucleotide sequence ID" value="XM_066756884.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989192"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="372"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0252941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="534" mass="58543" checksum="964E7BD8BD19D452" modified="2025-10-08" version="1">MLSNLGLFAAERCPDTKCTRPRCFFSHGLSISGPSQTQVPAGIRESAPRQPPTAVKRKLGESSNAAVMMEVKKQNVTSVAKPVAPSSATIPVRSAPPAPAKTIVSGGSSSSSTDYSRPPMLPYGIKLSPQPRTDRQKALGTLHTQFAKLYSQILHLSPSLAHDSSLAQEAEISSSSSSLRAYKTAIHHAAVAISRRPPPTGIPHPSIGTVKESRLAMEKDEKEKASKLTRSRVERYCMKKEDFEKWGYPDPSGEGLTGAGVETKPDGEGEAHNCDRCKMSFIVSSKNLEERFGECRYHYGRTAPERVEGRRKWIYSCCGKERGEQGCEEGIHVFKDGEDDKELAKRVAYKTVRMCLEDAKAPGKNVVGEGYGVVAMDCEMIFTTAGLSLGRVTVVDENGHTILDELVRQKVPILDINARFSGISPGQLDNAIMDLDGVRAAVCMFIGPETIIVGHGLENDLRALRLLHDQVIDTVIVFPHDKGAPYRRALRDIVKEKLGYFIQDRTSDKGHSSVEDAKATLDLLKWKVREDNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ38</accession>
    <name>A0ABR3BZ38_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615874.1">
        <property type="nucleotide sequence ID" value="XM_066755588.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987886"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="8">
        <location>
            <begin position="100"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0253653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="298" mass="34701" checksum="EC7065AF823CC93C" modified="2025-10-08" version="1">MFLGCWRLIIAAGEHEFPTRIMYRAEGIDWRDRARITTWFQQSILPDTVIEESSIYEDRQVSQMTFIYEKISIADRWAAHRVGQEVKYWNKAIADLPLLKVPSTWMDPMRNRLKALAMAEDCNPQRERAGVPVVVYINRQLTHRRLVDEDAKALLEEMAKLDKEGVIEFHNAQMEKLPRVQQFCLALRADIMFGVHGNGLSHQLWMKPGSGVLEIMAEGFARDYAILAEMMGHEYYAIHHNEIFPPEKWRRPDGWAVDQGPDFHSPNIRLDAKWFATLIADMAQRRIYVTEPELSLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ91</accession>
    <name>A0ABR3BZ91_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615906.1">
        <property type="nucleotide sequence ID" value="XM_066755620.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987919"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="575" mass="63021" checksum="1BB5A2D28C1AD3C3" modified="2025-10-08" version="1">MLLRLLPRPTPSTPSPLTILFTLSVPSHPYTSCSLPLPPALLSHRESSSWIMIIIEDVTFSLPLSTIAVNFTDGTSITMPITNECADALENVVEQVRMSFSAAGTNKSPTTSPKLSTPGSLSSASSTNGWSAASETDKVSRRTPSSLLLSLLSPLISNNPQSAPAATPKTMPHVTNTSNARVHRRQARSSLVDAYRRYVLPVLKEELPSAYLLWSVKSESERLLKEFEKVKEDVTGILTKSNVDIIELRRRIIPLTRCQSSSSSSLDEETSSLSADTETCSSPLTPATSISSTPVCQTPSFNARLFPTPQAFMTSLPVAHALPHHLRSSYTALYARLEHLVTRLSQMKKLGLRYEREEGKRRWLDGLECGRLADRAVRRGWSSKQLPREVKEILNATPLKGSKLWKSITAEELKRKESESNIHPAMMEDTPYASYGEEDVDSSSESSEEQLPVTPTSKPIFASYPLIRPAMPRLCDQKTNSSSLPVDAMPGDSELDQLSEIQHIKAPLPSVARNRLSYNSSPSWENNPVVGKVTSAMESLLLAGPLIKAKLAISGEDVGEEVQIEGFYGQCGLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZA3</accession>
    <name>A0ABR3BZA3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615939.1">
        <property type="nucleotide sequence ID" value="XM_066755653.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987952"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0253718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="79" mass="9059" checksum="6CEF2CA871AD4F81" modified="2025-10-08" version="1">MVNDRYVEGKSPASASYRQKLSYRLWLCGPEDDPLRVKKRMRCNLVHGVGWWALNCACSRSQHEIIPTALTLHAQDMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZF0</accession>
    <name>A0ABR3BZF0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615988.1">
        <property type="nucleotide sequence ID" value="XM_066755702.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988001"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1068" mass="115423" checksum="FD36772F9233F25D" modified="2025-10-08" version="1">MGAYYSMKSPEAKSTGRLDPLDGHVVHLHMYYAFPFGLSRLNTSATVNLPSTPPLPPPLLSAAPPSLTSPSSTGHFPIQQQQSEILDHSVDAVGYTAAGDDKTYDCWVFNAFSSPPSPSTIASNTDSQAGGECFPPSYESTEGESSSAASSTSRPQNLSLNINSLPATLPHLQHQLQSPSSLPSSGALLTDPFSSSRNTDLTQDYFQFSEGPVSGNAEGSFVSQISFDDDQQPQPQQNQQPQQIQQPNQRLPASQPTSPARGIFPHQYAPQIAGRQRGATFSGGSFYNFGQSNPSPFTFTQAVASQAIPSHFAFPPLQSPIDSPLASSPAIAASTSHLQGDGNALFNPSGQQQQQKVQQQQQQVGIMANNEISMEDMSTPTPAPSHMSTSRKSSLGHSHPPISQHSTVTQSQAQSHLGALTMEMSSEMIDKLSLLDKILDSAQSAKQALLRGEEIGVSTNLGDISNHLEVASELGVGPVQTPRDTTTPNSQTSQQSTSPTGNYLQSSPAVQTNVTAAPPQYQMSMASTAVPSQLSNLQMTVQSSLLPSLPVDQNATGTKRSATVQSINNSVSPGSKLATAEFLTGKLQAPPLTHAHSFPNGHQLPSQLTGTLPPTTPAVPSPSFIASIGAQHMPMISSPLATIPPSRPPSPPRYTLPTQPWDGEIAAMDVGLQQNGLGNASTQHSGQQMIERRLSTSERIDGRPIVRGRSTSLNKGWSHTTMTSSVPPSAWQSRAGSPVEDGDEDDDSDDDEPRRTKRRRSSVGADGLALDKANGGISDDIRGQLDQIFEEFLNRICSDLDVCDSKGEKIHQVLMPKKMQKLDESTDYRPFKFRIQAFTNAFAENLQQRGITEEIMSIKKIKNYLWRQDLISRFNPDGKKAKSKGNHIWNVDAKKLPGGGWVFRPFQRRIIGQPNNFAVVNQPYEWEPRIWDPQAASDTLHPKFSSPPGSLPHWLRWEDGVRLVGIPDQSTTPFQIQVHAEFIDGSGNHSTLDAGYPCQVVSQLLPVTDNASGPQQVYGQPLFNPSSQPHFEYLNHSLPGLGMAPSGQQIDLQFTNNLMYPQPGNYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZN3</accession>
    <name>A0ABR3BZN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_101219</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616062.1">
        <property type="nucleotide sequence ID" value="XM_066755776.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988077"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="147"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0253841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="333" mass="36652" checksum="D2093E4B67490EE2" modified="2025-10-08" version="1">MPYLRLPLPPFAHNNLAFSPFYDHHLALASGSNFGLVGNGRVHVVKMDQKVAGGLCLVRTWDTADCVYDVAWSETHENQIAAACGNGAIKLFDLALEGLPIQAWQEHTAEVTSIEWNNIEKELFVTGSWDQSVKVWNPSRRSSILTIPAHAGQIYSATWSAHSSAIIATCASDGFIRIWDTRTLPSPVQEIFPPSAASNPVSSSSAGEILSCDWNKYIPQLLAFSSQDGGVSTVDLRHVSRNAEKMAVRLVGRHGLPGRKVKWDPHNGSRLLSAGYDITCRVWQTDLPPATPPRELFSHQDHTEFVMAADWALFDPGLVASAGWDGELHMYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZU1</accession>
    <name>A0ABR3BZU1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamine synthetase</fullName>
            <ecNumber evidence="3 11">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_101279</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 11"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616122.1">
        <property type="nucleotide sequence ID" value="XM_066755836.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988137"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
        <location>
            <begin position="111"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0253901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="358" mass="39500" checksum="C8594FF3DB53EC46" modified="2025-10-08" version="1">MSQLIATKRVDLLAPYLALDQGSRVQAEYIWIDGDGGIRSKTMTLENSPSSVADLKEWNFDGSSTNQAPGDNSDVFLRPVAIFKDPFRGGANILVLCECYDNDGTPNKSNYRAHCKKVMDAAKDTEPWFGLEQEYTLFDADGQVFGWPKNGFPGPQGPYYCGVGAGKVFARDFIEAHYRACLYAGVKISGINAEVMPSQWEFQVGPCPGIEMGDHLWMARFLLLRIGEEWGITPSLHPKPLKGDWNGAGCHSNYSTKDMRTPGKGMAAIEDAIKRLEKKHLEHIAVYGEDNDLRLTGKHETASMTTFSAGVANRGASIRIPRHVGAQGYGYIEDRRPASNVDPYRVTAILVETTVLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C013</accession>
    <name>A0ABR3C013_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615947.1">
        <property type="nucleotide sequence ID" value="XM_066755661.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987960"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046784">
        <property type="entry name" value="Eap1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20566">
        <property type="entry name" value="Eap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="660" mass="72482" checksum="473EB8A560712DBF" modified="2025-10-08" version="1">MTPLSSPAHPLSHSHKTHTSDPNVNPFSPLSPDLAPNQLASAQKLIMDPVTDVASSDKPLITYTRKELLLIGSRCRDRGPPEAMGALESWFGDSNFEDPAIASISHSTGRRNNNNGGNGFGEGFGYGGGIGGGSRLHNNARGTRNIGLVLIQIVQADQLSLRRLPDGLDLPPHLTPPNVGEKGYSGQMGKFNVRSNNNMRLGGDEQKRERRNNNQGNNSNNNTEDWRKEKQTRENGYQQRDRDNRDHDRPYQQRDRDSHQRDRRNNWHQASQHDEDEQPEWMNDTMTPADPAIANDSDPFVKFTPGEDMIAAHKRAMKAKHANDWRGNIPSLPAFFASDPAIVSSAPVAASLEHKPKEINANNYLVETMERQEEPEQSQSAPQSAFSSRFHKFFGNGADQDSNAMANSQSAPVPAQQPLPPIQNQAVPENPLEQRKAALMGLLSTKSPTPKLEHDSPSQHFHQPNSPHVEIPSSMSTSNMYTSNTGFRPPHPNVLLQQLYNVGPSPNINPSPVNHPHQEHAPTDPLQLLAQAQAQRGQYVPQSQMAPQHMSLPPHFARPPPGMYDSPPPDVPTGFPPFMRPPPGPRYGPPPGAGPGYLPIPGYYQGPSRPSGMGVHGYPGPQPQQQMAPQPAQRYPPGQLNTSQQDMLSTLFAGLGPRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C015</accession>
    <name>A0ABR3C015_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616198.1">
        <property type="nucleotide sequence ID" value="XM_066755912.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988214"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="163" mass="17759" checksum="A250FFE3F52E90A2" modified="2025-10-08" version="1">MDAAFAIASQTQSPVAGGLPKAQDMTRHLNRMAKHREASALKELYKYMTVPGMITMAGGIPHPEVFPFETVSASVLSHDAFPLDPPRVPEKRKKSLISWLFSSSQSQSNTVSFTIPKYGPNPSDPAAIQLSTSLQYQPATGPPALPLFLREFVAKVFKPAYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C050</accession>
    <name>A0ABR3C050_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101391</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616233.1">
        <property type="nucleotide sequence ID" value="XM_066755947.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988249"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="66"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="369"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="529"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="848"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="445"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="677"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="865"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="882"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1000"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1038"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1077"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1111"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1161"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1181"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1196"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0254012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1235" mass="133413" checksum="FB757D415B7BCE8C" modified="2025-10-08" version="1">MYAPAPPPGQRYSPYAAAPPGPSQKHQYPNPVGSPHYPQQQHPPPPQRHKGTLHPGQIVNVDQCQVRIERYLSEGGYAHVYLTTSDTPIYPPSRRTEKKGRWGEKGYTQHCLKRIAFQDDSVWVDVKKEIEVMKSLPPNSHLVQYLGSSHTRSSAGQHEVFILMEFCAGGGIIDLLNKRLRDRLKEIEILNIFTDVCEAVAAMHSLKQPLLHRDLKIENVLSQPISMPPTPQRPTPLVFKLCDFGSTTFPADRPPQTKVEADALAMDLNRHTTLQYRSPEMVEPMLGLPVGLPSDVWALGCLLYKLCYYTTPFEEHGPLAIVNAKYTFPPMPQYSPQLQHLIASMLVEQPARRPTVFEVLRVAHEMSGTRPEVDYPMPSKSLPIPVQPRPTKPQSHSSNNLLDFTGSPSSLNKSPLLQPSLASTVQPQRRGRPTRDTRESPRPMVQNQTRWPQSPTTQALQKPQTTSNSANVRTAPSRLHITGENAPLSSGSAPLSATSPPPVDAFGMPIVPSTQLTATGFGDSFGGASVVSPTGTTTGSSQPSQRRYGPSLVKRPVGFGDSFGSVSVSGSGSGISRTPSISSQPPPAKPYQPPGVKRIPSGATTLESSKRQQASTMSQKSPEPPTSVPEGDGDLLFESRFPSIETLNSGGESTATVRSPPEKRVPPPVVSPPPAEAPGSTPAAPVAAAVSTFGTTLRPRPSVRNRPSMSSNLTGGHRRIADEDARQTIQGEAKMHVQPRSTQVTGTAFRGQVSGLAPNLAQGGGREGRGGYREQGRMEQQQEGLPVKRVQNGEEEEEEEGQKEDVSGKMDKKIPEDLMGSEEMGSLQIPSIVPIRSISPAASAISGISATTSAKDRGPPLSIDVTKTGSTNILSDNWSPLEEMRRRDAAERAEAAARKKEAGKAELERQQAEQPPNVHHDEKRRSSPEPVDSSDEEQGPEDPGMIIRSSAATAAQPTVAPNDIVSREPAKSATLPEPFTQTMGPHRIPSHKRARPQSMFLPNTSSDSVPSRNSLLSPPLRNEPSPLPSSQSPSQPSNLYTSQPSQGHQKKDSINRMVSKYESMSIGKPGEDANKRSPVNQQVPKPSEGTNTSSTKPSVASKPVNLRKPSADLSNNDSSAANTAQKDDPASPTKPRVASKPSTLRQDSGMGTGYIRPGMSASPSARPNPVVSTSFNSNPDRQGKEDEVVEKDSLKNAGSSPEKQQPVNLLIQRWNKGEVHNSSANAAKLKKGGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0V5</accession>
    <name>A0ABR3C0V5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Brg1-associated factor b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616433.1">
        <property type="nucleotide sequence ID" value="XM_066756147.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988451"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0254212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="56721" checksum="E7B9251A5F67F428" modified="2025-10-08" version="1">MVYNGDEVSALVLDYGSYTTRAGYAGEDCPRVVCPSFYGYTNDPSSSGSNGNFSGGNVMNKENGEDVTMSEPVSEGAEEQSKKKGSGRKYYVGEDGVSVWRPEMEVGNFMLDGVVNDPEPASALLHHVLHDRLGVNPEEHPVMITEPAWNTPKARQVMAEMVFEGEKMPALYFGSSGVLSAFAAGKPTALVLDVGYATSSAVPIVDGYALRAGTMHQPLASQLIVSQLQNHFTSPTPTRAPLSLLPRQLIKQRDPSSDPGIIPKPILRDDRAPHTTTSWKLWAENNVVEGYKEACTEIVNYKGFDFQTAGDLPQVLYEFPDGYHQYFGEERYRFTEMLFDPGRYYNQSIPPPPTLQKVLTTEHSRSLRDLVSLSQLVHDSVMACDVDVRASLLQNIVVVGNTALTRGLIERLDVELAATMPSQKIKIHSPTIPFERKYASWVGGSILASLGTFHQLWVTKEEYEEHGMPIVHQRCKYSKCNIMLDGDTQSLFRFLRKYSNIYSIKVERNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C116</accession>
    <name>A0ABR3C116_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101238</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616081.1">
        <property type="nucleotide sequence ID" value="XM_066755795.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988096"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="627"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="38"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="217"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="741"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0253860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="814" mass="89675" checksum="6FE2351F76C3B6F6" modified="2025-10-08" version="1">MPSQVPASPTAPGPPVRSAPTKSTSLLPSGPINDNPYNVDLVVPYSIALSKKDLKNRSHAEAEIKERYVYLLRELERSGFRLASKAGRGNKGREEVWIFVGASEERVEQLLKEERRLDASHNLLTAPSAFPPAPATRLRLIYNMLTAPKLQGGLGITPGRGKWSRVKSISALHDEAADKAWVEKWTTGGDWQVGLTKGLDEDTRKRGGLGDQQPPPIHLYFEFLTTYTLSLFPITVVSVLFYFFTPADSYPPLYALCLSLYSTIFIAIWRIKQRKFAVKWGTYGCENVAFGRLRPEYVASLGLDKTTAQQGVETVDAVQAGNELRRDTKVAASVPIIAACGVGLGVVLMGLFVLEAFVSQLYDGPGKKIVPLIPTGLFVLIVPSIVGAYQCLARLMVKWEDHPTPVGEEKSLTAKTFAMNAIVAYLGLFLSAYIYIPFGSFIMTHVQTHLMGRLPVPVSRSANSTSPATSATSSAAASITAEKHAINGGRLKSQLFTYTVTNQVSGAFLELGMPFIMRFIQDWRAGKTTIKEALKKTNGHGDSEMVPATEEEIEKRFLNKVERELALPEYDTFTDYAEMVTQFGYVVIWSLVWPLAPVFALINNYIELRSDALKICKHVRRPVGDRVETIGSWLETLSIISWIGAITNATLIYLFRPSPVSPDLHSQSPNPNFPTPGSPSLSHIVSAYHSSSSLSEWYPQLAILGLWALGASHGYIMLKWVVEGIVERLWWRGSVEEREVQRMRAGSSSPSTSKLGDSPSKSISAQNPEPEFRYGGETDQNNGSDKMLGKEPVSAFWNGGEEGAKEIARIIKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3E7</accession>
    <name>A0ABR3C3E7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616270.1">
        <property type="nucleotide sequence ID" value="XM_066755984.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988286"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF3">
        <property type="entry name" value="F-BOX PROTEIN POF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="172"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="483"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0254049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="715" mass="78746" checksum="8A479A5559C6F265" modified="2025-10-08" version="1">MPPTLTDLPSEVILEQILPLLSLKDILYLSQVNHQLHTLTLDPSFWRSKTTSDFSFSPSSHPPFPSSDWWRRVYFGLLQPRAFLWGSSSNSRLGGAENSRGTRKFGNFVDFPVEIWLNERESGEETRIKSLKDSLVGLTDGVASDAPSGPGGPGVVELHAGGWSFTARCSDGSVWVWGQLDGRMMSFRERSWENKYCIVPEPTRIPLPCKAESVSAGRSHLLILDSDNLIWELTAWGLAYHHTETELTSPVHYGTNRQPPHVIQLSTGWTHSAALTSGGTIYAWFPFSDSYKQKLTPDAELNVLNPPGVENDADNGSRSLRWGTTAEDSNSDAKVLELLDAEWKEYDSAHTPETVRDGQKVIKIASGLEFILALKKNGEVWYIQVKDGVPPVWYFVPYFSSPAITHITAQFESITSYATPTQQSQSSAVHHTRIPADTVPPRSFTSEPTVLLHRPDFLPDLQDKGVIQVALGDYHYAALTNRGEMLTWGQGTTGQLGLGAEGRRGNETVPKPVKFWEKEEPGFVFSITAAGWHTGALLLGNNEFKKEEADEFAAQSPIHRTVDTASNPQHQRGSSNIAPNEQDPRVTGGNHLPPFRLGYPGRLMFRGVRGGHSQMPASVQDEIDPSTANEHSAGADQSGTSAFPDQAADIQRHTDSADRDSQWQMPQHHVSSRGVRAMPFFRVGFAGRGSVRGRGRGRPGINDGNGIGFNPNGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3R9</accession>
    <name>A0ABR3C3R9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616558.1">
        <property type="nucleotide sequence ID" value="XM_066754657.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986936"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="174" mass="18983" checksum="4F48C30F3556DF0F" modified="2025-10-08" version="1">MLSTSDIGPISQQYAAAATVPLIKSPSLWLPQPVELPNEIHPLPEDITAYFVYPFTLEEHVLSIHPSPHEAISLKRAKCAEILHRREEAEEQKERDNLKRIAPGYNPSSVLVPISASHTPTSSISRPLAPPVDANGGAPSVTSPRSSDTHTQAQAAIDPMDDLVAKLEEMESKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3T2</accession>
    <name>A0ABR3C3T2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616572.1">
        <property type="nucleotide sequence ID" value="XM_066754671.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986950"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="141" mass="15445" checksum="50EB9DF007FA9475" modified="2025-10-08" version="1">MPSIPFHAVDTKGKVLGDNFAPAAAVILPANAKTLYISGVVGENEDGSFGDFRTQVFLIFDRITEILLNASPSYKSAENAWKHVFEITAYHVGSLPEHLPVELEAVDKYLKGAHPTWTSAAVEKLFHDGQLYEVHVKAIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4F1</accession>
    <name>A0ABR3C4F1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100149</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616626.1">
        <property type="nucleotide sequence ID" value="XM_066754725.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987007"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="9">
        <location>
            <begin position="71"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="382" mass="40697" checksum="BF6A9A3128BFFD33" modified="2025-10-08" version="1">MSDFHQAPHKLLVIPGPIEFSDPVLAANATPGTAHTSPAFIPVFGEALSLLRDVLLSTKESGSQPLLIAGSGTLGWDAVAANLIEQGEEAVVLNTGYFSDSFAECLEAYGAKVIQVKAEIGNIPTDDAIISALASKPKLLTITHVDTSTGVLSPAGHIASLVKKYSPNTLIALDAVCSVASEEIRFDDWGLDVVLSATQKGLGVPPGLSVVLASKRAVETVEKRKSPIPAYYVSWKKWIPIMQNYESGKPSYFATPPVQLVYALHTSLKSITSAPLADRFKAHKAASAYVKDSLAELGLEFVPKSRDIAANGMTAVRFPKGLKAPDVLPKLAERNIVVAAGLHKAIVSEYFRIGHMGITAVDRQRGDLEKVVKNIKEVLGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4N7</accession>
    <name>A0ABR3C4N7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616865.1">
        <property type="nucleotide sequence ID" value="XM_066754964.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987251"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33517" checksum="12767142F75C0AF8" modified="2025-10-08" version="1">MSYQYSNPYRGYYGHSEPPPQPYEKRIPVEEQFKVLFTGLPEGLTSQDLYEVLTKPPLSLPRTIHVFNMHQPDGHFLGIAVVSVDTQVDAERLRVEYNGKVIDHNYRLSVHHILPVGHKYPLFNAVGSSSAIQSGNVQHAQSHASVSAKKSNPALRTHAQGSSSNANQPGSKGKQKAQSSVSNKKENGKPLGPKLLDRISKPKVLPNHTDQIALLERQRANLQKSHTVGQGKASIMRIQPSIPSKDTTRRPRKSKADKAATKSNVGAASKVSRAKKKLNDSAMDVDVDLTFGNTANYGQGYWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4S8</accession>
    <name>A0ABR3C4S8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_100303</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8 9">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8 9">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 9"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616776.1">
        <property type="nucleotide sequence ID" value="XM_066754875.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987161"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="11">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="8">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0255499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="327" mass="36357" checksum="B9A654DAA99F39B3" modified="2025-10-08" version="1">MADDPSGWSLTESDPQVFTQLLKDLGVKGLQVDDLYSLDAETLVTLKPIHALIFLFKYVAPDAGSSQESAGVEVDPLDNGVWFANQVINNSCGTLAALNAVMNIKPQQSVHEDESIQLGSELENLREFGAGMQSLDLGHVLSSSDHIREVHNSFSKSSPFSMDPSALPEREKEDAYHFVAYLPVNDILYELDGLRRSPIMHAPVEDDWLSTARETIEQRIATYPAGSLMFNLLCVRSAAIPRLERLLNDPATPAEQKFVLQDQLEHERNKSQKGAMENSLRRHNLLPVVFQLFKSLGENGMAAKAVEDARAKGKERRERMQAKGETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C532</accession>
    <name>A0ABR3C532_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA repair protein RAD7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616743.1">
        <property type="nucleotide sequence ID" value="XM_066754842.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987128"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056451">
        <property type="entry name" value="Znf_Tbcl_Rhp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23550">
        <property type="entry name" value="zf_Tbcl_Rhp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair protein rhp7 treble clef" evidence="2">
        <location>
            <begin position="149"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="326"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="66364" checksum="3A7E81FD64EAF120" modified="2025-10-08" version="1">MSRRSRAGGAVRGPSSALTSFLAGLGVEPSHRINTWGDRSAVETPTSDGHHQHADPANVVTDDNVEAGPSSVGLGTPSFNEEGDLPVGFKRGRGTNSDEDYKIKRSRATSIDSDDLDADDTPVVNHNSRTPKSVPQSSTNVPAGPMRPVGEFMVCGECTKRFTVTAYTKEHPTNAQTYLCVQCCYALGIDPFAKPKKAAAKKAVKKQDRAKIVHYEQRRGVNSLGDICIQLVGKYIENVEQLGDIGSINMDKVCRIICKGRRLTPETAPLFYSVERDSLDMYDCTRITPEAFFTLANLCPNLQTLRLDLVGQMSTEVVSYWAKTLKQLKRIELHAPFLVRKEAWIEFFRAAGERLEGFLVTQSPRIDRETAHELVKNCPNLTELRLSEIGKLDSEMLEELKPLKKLRFLDISSPPDSLTDDAIINLLEAVGHSIEGLNLADNFDLTDAILPAIAKYCPRLHSLSLRNLTELTDEGVTAFFESLQAKDHQGLRCIDMEKGHELRDSALGALIAHSGETVEWLSLLGWKEVALEGLNALVKCKNLKYLDVGWCRAVNNFWVKDVLDGCHAIEQVRVWGCNELSDGVPRKKGVKVIGIETHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5C7</accession>
    <name>A0ABR3C5C7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617099.1">
        <property type="nucleotide sequence ID" value="XM_066755198.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987489"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="186" mass="20576" checksum="6C4DBB83E92ABBBA" modified="2025-10-08" version="1">MGLSLSRIYSSLSSLAFWGKDKEVRILMVGLDSAGKTTILYRLQIGEVVSTIPTIGFNVETVTYKNINFQVWDLGGQSSIRPYWRCYYANTQAIIYVIDSSDTSRLPTSRSELLTMLSEDELKSVPVLVFANKQDVEGALSPGEISDKLGLAGQEKGREWSVRGSCAIKGEGLEEGLDWLVNTIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5D7</accession>
    <name>A0ABR3C5D7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617113.1">
        <property type="nucleotide sequence ID" value="XM_066755212.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987503"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="269" mass="30455" checksum="6E22CF11AB0557E3" modified="2025-10-08" version="1">MIHGGYTALAILLNDLVQWNLLLTPEMIFLPTLQRSKSVQDEKRLAEILKDRVERIEKEEARVQRAKRKIAQVVQMQQAAEMRSTRTRRPVRKVDYIYGNEDEDEEPLPTRRSSRPSRQSGRDEESYSALDTRARPIIPGERRSTRVSGACREVVEDEDPRPPPPPPQPEAVNGLANGKKAPKGYAWVQESVGGENSSPGIAAIDDQQQVAEPIPAKHEDFQSEDQIATSLGSIKTIREFEQNKEDTRLGMLESDKNNEQTEMKMEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5U6</accession>
    <name>A0ABR3C5U6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoporin NSP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_100513</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616983.1">
        <property type="nucleotide sequence ID" value="XM_066755082.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987371"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="10">
        <location>
            <begin position="523"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="325"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="673"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0255706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="758" mass="73827" checksum="504A71F2690A3783" modified="2025-10-08" version="1">MSAPNPFAGFGSKPASSTTNSLFSSSNPAQPSAPGTSLFGNASSQPASGGGLFGSSSTTNNSTAAPAPSGGGLFGGGTQTPGGLFGNNATAGANNNNNNPTTTPANSSAPAAPSGGSLFGGFGTSNAASGSTTPASKPALGGFGQTTTPAAPPPANTGTSLFGGAATGTSTGGGLFGAKPAEGAGATGGASTTGGFTGFGTKPAGTTSAPAAGGLFGSKPAESATAASASTAPTSGGGLFSFGAKPASTTTPAAPSLFGSAPAKDSSSSTPASATTPTTSGGGLFGGGGLFGAKPAVPAAEAPKADTTTAAPAAPTGGLFGGIGVSKPAEAPKPAAGGFSFGNMGAAKPATPSVTEAPKSGGFSFGASAPNADKKDEKPAEAPKTGGFSFGAPAATASNQEKKTDKPAEAPKAGGFGFGNVGPSATTASGEDVKSKAPEAPKAGGFSFGGLGAKTDGDKDKTPAAPAAGGLFGAKPAEASQSGAAAPSTGGGLFGAKSSVTPVASTTAPAVATAPTASAPANVEKPSEPSPNLLRGKALDDIVEGWNKDLEEQVREFERQAGEVREWDKILVRNGNQITALRRQVLEAQQTQAAVDEPLNYFEAQQNQLESMLDVYEKEIAKMSNDSTRPLAAKMPADREREKAYTLAEDLNKQLDDLSRNLSQMIEQVNKISTSQSSLDASTSPLTNRPGTPSASAADAASQMPDDPVNQLSAILGAHLRALSSIDSSAGKLSVKVGELESKMGSNGSARGWGLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5V0</accession>
    <name>A0ABR3C5V0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617290.1">
        <property type="nucleotide sequence ID" value="XM_066755389.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987683"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF13">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0256013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="51472" checksum="9FABD1CAB9420F99" modified="2025-10-08" version="1">MTFAFTQTSPIYAFRIMTCDEYYKTHDEWTGTGDRCSVPKIEADSASQIAIMSTVTTSCTITNLFIRGWFIKKFGCKADMFQQTFWAALRNLTQMYALSIGGNTGMQIIQTTQLFNVLGSGGGYQIASNVFISTLVAAEERTSQFRVLTGVIMLGSSSGYTFGGLAYNWFGLLAPFQCAFALLCFCTVFGSLFLPHILPENDQRNNDKEKKRKSFLAPLRIFVPTRNVIVGNKTKHDYDLLCYSWLVGHFSVFWRQGESGIMQSLNLLVKVFFLFICFPRIIAAGRRYVSHRQDVPSFAAIEHPENSYQAEEPDDIGAPRQEQAQAPTDAKHGSLFDLYFLRWSIFTDGVFTALTTLSTKGWHLYVAACVLPFASGTGSACKGVILDFVDSEERADALSAIALVEKIAQVSTISVFGYVFAWLSEEGKPTLVFLVNGLTAIIAFFFLLSVCMPRPGEVKVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C696</accession>
    <name>A0ABR3C696_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616952.1">
        <property type="nucleotide sequence ID" value="XM_066755051.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987340"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="102" mass="11302" checksum="60094A1EDB787C4B" modified="2025-10-08" version="1">MSAQQQATATSALPSTSHTSQPVQPSKLAKNPRLPATMITPSGSIQTSQKNKSHKGQISKKKRAKLEKGREKAAELSGKLEVKVREREDRKAKRQRAKKAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C721</accession>
    <name>A0ABR3C721_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616838.1">
        <property type="nucleotide sequence ID" value="XM_066754937.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987224"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="63"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="544" mass="59491" checksum="F4FDB41A0529951F" modified="2025-10-08" version="1">MCIPQSSRKQHIVLYTAAKFHVIIVAMRLPWMKKNADLEPKTEDEPHDSNFIEKKPGLSKMGAIFAAGASLFSDGYANASIGPATTIIKSYIYPDLFESRPVNSRLLPAIAFAGIIVGQLSFGWISDKVGRKFGMLLCTGIVFVFSALQAASKGVGGAQGTINALIAYRFLVGIGIGGEYPTGSVAAAENTEDPGIPKARQQRLFVLATNSMIDAAFVISYFVCLVLLWIFGMNHLNAVWRMTLGLGCVPPLFLFYFRLKMKEPESYAKYSMKYTRIPYWLIIKRYWVKLAAVSITWFLYDWITYPFGLYATPITDAADPNGTLYTSIGWGCLINFFYLPGTLFGAFIVDYLGPKYCMIFGLCMQAIFGFVLSGCYNLLTQPHRIAGFAILYGFFLSFGEVGPGNNLGLLASKAIGPTAARGQLYGIAAAVGKVGAFIGTYTFPQIQASFGKHGKYAEDTGVFYLGSALALASALITLIFIPNIQPDAMHEEDIAFREYLEANGFDTSKMGLRDSVSDIEVGDGNSDEKDNKVSAERVETHALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHU5</accession>
    <name>A0ABR3BHU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610782.1">
        <property type="nucleotide sequence ID" value="XM_066760957.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993385"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF103">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="220"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="452"/>
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            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="61004" checksum="9F06926DC9D3836E" modified="2025-10-08" version="1">MASRNSKAGEFADDSKEAIRNLPELNTGTNTNSRVLVTEADTDNTAKFYNEHKEAARPLTPEIVHALTRRNFWYLLCQTWWISFLIHLDESTLSQASTMGIFDDVNMTKKQYNDLFVLYYTGYLVGLWPGAWIAQRIGHKRFITGSLFIWALLVGVHPAVKTGQQLTAVRFLLGLTASQIVPSTTVLHQSFFPPKSSPWVQLLWWSAGSLANVLLTMVAYKLIIDEGNGVLVAGIASWKWMNIMCAIITFVIFAPLVIFLPNSPVDAKWLNTEQKVHTITMIRDTHSGIANSTFKWSQVQECFTDIKSWMFFFHMFWNEIPNNTSQQLPLIIVGFGFTPAESALLNIAKPLWGSVLVLITAAMMYGTKLGTGYVCAISYLPCTIGGIIELTAPWSNKVALVVGTQISSFKPSYLLGLTWAGTTTTGYTKKMCLMTTCVIAAAASNMIAPEFWQEKYQPRYRLPWAFMTAAWVICPLMCLLIRFYLKKENDRRDKLMAEQQLAEGEADKGLLAISGEDHEVLKIHVADLDLTDRENLKFRYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI53</accession>
    <name>A0ABR3BI53_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610883.1">
        <property type="nucleotide sequence ID" value="XM_066761058.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993490"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="73173" checksum="1391AF3966DECD58" modified="2025-10-08" version="1">MPPKRTAETRDSATKRARTAQSGKDETADPPIAVAEDTQPTGAKLKGRTKGGKGKSKAEATSDYPPTGPKKRVRKPFAAKEVTWRDIPDWGDRTDVPLFRLPAEVLDLCFGTKLNVGLQLRDYVALAGVSRYFRFHFTNDVFREIYLKSHPNYLKLRPSACRSPIKHSQLIFTRPVNDWRQDPPLKKFDKLEIHMHSIPPVEKWAQKDYEFVTRADRLIAQARQVWADARAERANRKKEKMKKRRVLRKVIVDGISRTVLATVPGLKHGETQGPKNELGVPILTDESGKEIELDASHAEKEKNDDDEESDDELDSFSTVREWDWEESVHNKDCELWQKIHKLEDKMKMLRKTYDNYDKGVDFSDISSEDEVGDEEKEGDKSVSKKGKKKQAKRKFVRDPNWVLPPEEQPKKPHATLVEYDPLTGEKVPHDAYPSPWRARAVEAANKKFINRADAIRVFKVGEAELLCLKHYLVPNPLNPKTPSSIYSLAAIQALALRSHGGPIGHHYHVEAANERALKSLVTRQANAAKRKADPAYVEKEPKSKQYPQTTIDPDDIGAKYGVDKDCGIWHYQGTFIDFVADWREHRAAKAARKAQRVANGEGSESSDEESTPNQDELLPVPSVPWNGVNEYMHPFVEDDDEFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIK6</accession>
    <name>A0ABR3BIK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611027.1">
        <property type="nucleotide sequence ID" value="XM_066760755.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993177"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14297">
        <property type="entry name" value="UBA2_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="667" mass="72369" checksum="C6ECE64F02575EAB" modified="2025-10-08" version="1">MSTKPKPELIEQLKALGISERTAYFALSKTKNDVAKAADYALSGAAGKDEVSDKPKQFQSSKESSSSSQRPSLASLRRLSFNASETPSLESNVSKLPPSKRSSPSLGSLTLWGGRRKKINSDMVEEEQGLAPKSMNTNEDEKERGRRRKRSSSKCTLMTENESELTQTVPPPLPSNTYPPSKSTPPMAMLSLDDQVSNLILGAIDRGRPGSSPNVDSSEMKKTPSALAALGLRAAAIGSSSSVTPAPPKSPEKIVEPAPKEATEMKASFLQPSMPVGGASKGPTNRAPSPFFRARRARDQARARDTSPEVEALKKDKDNGESDGESVGGAKKFRPQALAYEDESASEVETEEEGSGVDLDDEDILDEDGEVIFDEETEKNTEANAVFFEGDAAGLGGRAPTDDLDAARDDTDNRSQLDFYGEEVEQDVLGEGPNVVIPPASVFAVPSSQTRGKKNKNVRAGLHLDTSRPSFARDRCTITLTQARDGDEIFLISVKEDESKIDPKSWSESDRAQKLRIQKERQTTTLLLVKQVTGLLSRTRLQITVTCQFLHAKNARHMLIDLIDFLEPTMVIVGSRGLGKLQGILLGSTSHYLVQKSSVPVMVARRRLLRPLRRTNPANLRHSPRVSLASASIEKAASSKQEDDVVDVAQEEETTDEAAIAAGQRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIP8</accession>
    <name>A0ABR3BIP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611062.1">
        <property type="nucleotide sequence ID" value="XM_066760790.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993214"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="53"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="440" mass="48865" checksum="6C493957811EFA03" modified="2025-10-08" version="1">MSSSRLSLRSLPHLSPSQPRLSPRVVHPRRFHDYIRGPMAKGTYKVPLSSPKVVGSFSSRGHREYQEDASSIQALQLDPQELQSSLSRLKTQESGRVDWDPSTAGSQFLAQQVAYFGIFDGHGGKQVSQYLSQNLHALIERVDSTSIRPVVEWTKEKHGGYFKRWRGGALQRWTQWADGEVGEGDGGREEVGWGEAGRGEGKVLMTLEERLTLAFLQANKEILTSIEHSDRCGSTASVALLHSLDSPSQPYWAANKLALTIAHCGDTRVLLCNRETGLVTPLTEKHHAESRVEASRLRRMGAGLLVSDSYGESRWMGAVENTRGFGDGRWKPSGVTVEPQVETRVIDGDAIAYMILVTDGITSLISDQEIIDLARRSLDPSRAAKTIVHFAEDLGASDNCTCVVVPLAGWGDVRGEDRTVDRREYRRRHAETMSTRMQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ85</accession>
    <name>A0ABR3BJ85_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611242.1">
        <property type="nucleotide sequence ID" value="XM_066760481.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992887"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="6">
        <location>
            <begin position="658"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="618"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="307"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0241860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="883" mass="98661" checksum="35C54BA37045023F" modified="2025-10-08" version="1">MAPFGGHGSSGRGRGGFRGGRGGRGGKGGYGGPQLPSSLLEQVDAKYGSGGKRDMTRKEKRKAARDDRKGPAQTQKTRGRPPSSDDEEEEEDEIEQPPSKKAKTSKAKSASSSEKSKSEKKEKKKKLPELTLPEESVGGDVEDREIEWLEYMLRKEKGKSKDEDDLDDGLDDLLNFAEVFERGGQGVNKQILDDEDDEEIYDFGEEDEEDGEEESEEDQGKDDDEDNEIDDEEEEFMGFSDQEEDQEEKEDFSEEEDVSVEEDESLVQKRDQTRPDDAEPSAPSDSTASSSTDAPAPSKYIPPHLRAAQLEEKAKGNKEKAEEKVRLERKAQGLLNRLSEQNIESILAELETLYRNHSRNDVTTALTDLIIQMISNKNNLLDSFVVLYATLVGALHRVIGMEFGAHFLHTLITKYNGLQNQSILSAEGQQSTTIQATIYETPDAGKESLNLLTLIAELYNAQVVGSRLIYDLIRGFLDGEGKEGEVMGEREVEGLLKILRCSGAQLRTDDPASLKDIVNLVQEKTKGKEKTMTARARFMVETLTNVKNGKVKSSATSEAGNDAAQRMKKFLSGLGRKRRLLAYEPLRVSLSDLLSADKKGKWWLVGAGWSGNPLVELEQQREKAKSSEKTGKSGNKEEDKDSEAALLELARKQGMNTDVRRGVFVVLMTSEDYVHACDRLSMFKLSDVQQREFVRVALHCCGLEATYNPYYTLILSHLCANSYDHRFTFQYALWDFMRELESGSKVSKQRVGNVARAVAYVVARGGLSLTVFKAVDFTSLSKPLTKFLITVLVHFVIALQTVSPIFTLPKSYELVRNFDDEVIQERFEQVLSNTELAGGWLWVLDREMKDGKKWEEEVTGERERAVVKKSLGIAKNVLRAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJA5</accession>
    <name>A0ABR3BJA5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Claudin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611056.1">
        <property type="nucleotide sequence ID" value="XM_066760784.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993208"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27032" checksum="6A0885CC9C2E63BC" modified="2025-10-08" version="1">MRGEHCVAGATILSVISVILLIFAHIGQVSSGALVKSIYMAEVNVAAYGNGFQGGTNTSASGMYDTSRTDLMGTFKGLRQYYRFGMYNACGYQKDGGGICNSSAFAYPMEPLGAMIGDVPAKFRKQTVDIIPTSTFKDNSYNHGMTRAGTGLIFVGSCGAALALIFGVIKLRLTFFIASICASVGAFLLMLGAALWTAVIAKDAWLQNVKVQHGYKLGIYVTAGPSLYLVWVAFAFTSLSCLPYVIACCTYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJK9</accession>
    <name>A0ABR3BJK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Yos1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_106152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611360.1">
        <property type="nucleotide sequence ID" value="XM_066760599.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993007"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0241978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11094" checksum="5BCDB4BECDFA5FD1" modified="2025-10-08" version="1">MVFGYFGSLFYIGLLFTNAIAILNEERFLARIGWSTRVPSTANAGFGHSPAPQMFDTAGFGGASGSEGAGVKAKLVNLIGATRTLMRIPLIVVNIGVIIYEVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJL0</accession>
    <name>A0ABR3BJL0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">carbamoyl-phosphate synthase (ammonia)</fullName>
            <ecNumber evidence="7">6.3.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_106149</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="7"/>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611357.1">
        <property type="nucleotide sequence ID" value="XM_066760596.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993004"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="199"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="735"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="14">
        <location>
            <begin position="1000"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0241975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1154" mass="127144" checksum="A19DAB0F32A6FCFE" modified="2025-10-08" version="1">MLRSLPRARAVLPLRSRPLAPLARSPLARNYAVAAPAVGSYAQVDGEPTLNSPSELARKISAKVLPKLEKPDVKKVLVVGSGGLSIGQAGEFDYSGSQAIKALRESNIETILINPNIATIQTSHHLASEIYFLPVTADYVAYVLEKERPDGILLTFGGQSALNVGIQLDKMGVLERLGVKVLGTPIRTLEVSEDRDLFVQALNEIEIPAAQSTAVSTIQAALDAAKEIGYPIILRSAFSLGGLGSGFAHDEEELRNLAAKSLSLSPQVLIEKSLKGWKEVEYEVVRDAADNTIICCNMENFDPLGTHTGDSIVVAPSQTLTDDEYHMLRSAAIKIVRHVGVVGECNVQYALDPVSRDYRVIEMNARLSRSSALASKATGYPLAYTAAKIALGHTLPELPNAVTKSTTACFEPALDYIVTKIPKWDLAKFQHVERNVGSAMKSVGEVMAIGRTFEESLQKAIRQVDPNFTGFDAYWKPEDMTAALTHNNDRRLFAIAHAMLNLDYTVDHLHDLTKIDKWFLYKLENIVNVYKTLQSTPFDKIDRELFLTAKKTGFSDLHISQLVGVKEDEVRAARKAAGVTPFVKRIDTLAAEFPAYTNYLYTTYNASTHDLEFNEKGTMVLGSGVYRIGSSVEFDWCAVTCSRAIRSMGKKTIMINYNPETVSTDFDEADRLYFEELGWERVMDIYELEGADGVVVSVGGQLPQNIALRLKQTGVNVLGTDPEQIDNAEDRHKFSSILDSIGVDQPAWTEATSLQAAKDFANKVNYPVLIRPSYVLSGAAMNVVWDERQLEEKLTAAADVSPLHPVVVSQFIDNAQEIDIDAVAHEGKLLVHAVSEHVENAGVHSGDATLVLPPFSLQERDMERLKEIAQKVAKAFNISGPYNMQIIRKPEEEGKEAELKVIECNLRASRSFPFVSKVLGKNFIDVAAAAIMGENIPEPIDLMKEQRDYVAIKVPQFSWTRLPGADPFLGVEMASTGEVASFGKDIHEAYWAALLSVNGFKLPKANSGILLGGDISRAELPEIASNLISLGFKLYTYDADVEEFINKQPYLSIKKILVPVKDKRKLREVLEENEISCVINVSRSRAATTADADYASRRAAVDFGIPLINNAKLAVLFTETLQQKFKNSPLPYVEGQQPSEVKSWREFVGEDRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJN9</accession>
    <name>A0ABR3BJN9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 8</fullName>
            <ecNumber evidence="3">2.7.11.22</ecNumber>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_106173</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="3"/>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611381.1">
        <property type="nucleotide sequence ID" value="XM_066760620.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993028"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="32"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="58"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="421"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0241999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="468" mass="52209" checksum="B0797DD10A109DAD" modified="2025-10-08" version="1">MASIPGGGTIMDPMHLYRARRDKERRGVLKTYKILGFISSGTYGRVYKAVLLPPPKAASAKSALPSSTRAALSLPKDKLPSPSFTEDNDPLNNPEMCMRPGDRPAKTGDVFAIKKFKPDKEGDVLTYAGISQSGAREIMLNRELHHRNLVSLREVILEDKSIYMVFEYAEHDFLQIIHYHSQTARASIPPSTLRRLLHQLLCGVHFLHSNFVLHRDLKPANILVTSQGVVKIGDLGLARLWHKPLAQQGLYGGDKVVVTIWYRAPELILGAKHYTAAVDIWAVGCIYAELLSLRPIFKGDEAKMDGKKSLPFQRDQMGKICEVLGPVKPEQWPGIIHMPEYRTYQATGPYPHSNPLAPWYHARSSSSEGYDILIKMFEWDPARRITAKNALRHPWFQEEGGVDTKSVFEGSSITYPTRRVTHEDNGDAKMGSLPQSMAGGRLPSSSNFRPASGNIAQPAVRKKARIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJT6</accession>
    <name>A0ABR3BJT6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611251.1">
        <property type="nucleotide sequence ID" value="XM_066760490.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992898"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="46"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0241869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="570" mass="63091" checksum="C22DA6224D9F7FF9" modified="2025-10-08" version="1">MPSSPSALERRPTKITKMDDSMDVAEAITGTAPVPSYRPDAKARRYDRQLRLWASAGQRSLEQARVLLVGCDAAGSQSLKNLVLPGISQFTILSSKTTTAQDVATNFFLHPDSIGSNIAQESVKYLKELNPAVEGEARTEDPAIIIKADPQFFLSFTLIILSNVEPSLENQISEILWEASSSIGGPDIPLIAIRNSGFISRVQIQLREHTVVDSHPDTTHTLRIDEPFLALEQHARSLDLANMDSMEHSHIPWVVLLVRAASLWKESHGGKLPETSEEKAEFKEKLKAEKIKGDEENYDEALAQAYRVWSKSDVPWEIKGLLNDESVKNISTNSKNLHILLHTLNQYIIPAPHLPPTSPSLPDMHSSTTSYVALQNMYKTQYRTDLKQFKYLLSEVLQNVGLPADTVPDEEVEGFVKNVGGVGIIKGTSLSGSKNIRGLLLTELENFDEENDSATCLSMYLALLASETFFESEKRWPGASSSDNLAADNQKIQQVLLDLFPNFSEGLPEILEQSLEEVIRGGFATIPTTAAFVGGIVAQEVIKLVTNQYTPLDNTVVLNLIKSESYKFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJY6</accession>
    <name>A0ABR3BJY6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610884.1">
        <property type="nucleotide sequence ID" value="XM_066761059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993491"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="677"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="677"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="753" mass="81796" checksum="6492E7E04015DAD9" modified="2025-10-08" version="1">MDETPKTAVLRTPRAAFDGGEVRIEGSVSESERGSIDMGTVNGERKDKGKERAVESAEDEDEETSRFDMELLGRLQSRVNELEASGKTGDEWMQRNELLGMVKTLLPLTLNHLPFLQERLAAQKSTIATMQQQAKVSEQLMATERERHAVERESWHKEMRAVMVSKEEEKVSSKRKVLDLDVGYHKELEAANKRLEMDNRLMAPRLVDTQRQIDRLVNELRLLRPHVILNTQALTSKPTESSPATSAPPVFLPQYMPQLENSKESHRSSRATMGDARTEHLLLAAKAIRRMRKNNGQLGRLTMGELKKAGVVGPEGGMGYKEGYGEQPMSDVEEDASEEEPEESLIDQRASGSVLKGKSKSQGTPLLPRAKRSTKKNPQNASISTIPETPSKPRAAGKPSLPQTTPGGSNFNDLLRAAEMATRPSSPVHGEPILSTLSATRSTTRPRPDSSDTERGSPKRRRGAVWESGESHKTHQHSASAGSASALDLLAQASQLDVASSTAPSSVVQSSPAVPLTSSTPQFGGLLEKDSSPRSHGSSLGAPIDLTPQNRTMANVHARAHPASDDFIVDPSLQTPTHRMRGSSTASESLTPARGYANSQLYPTPGGELDERLPPAGASSSAINPTATLGVISEGGGPGTGNGNFASPSGKVVPGLGRYWHYTSEMPIKRVRSPYLKWTVEEDELLARAVAIHGEKWDLVSKGVPTRSYHQVRQRWLRKTGAFDKKNQAAKAEREAKAESTSGAKSSSTDGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK59</accession>
    <name>A0ABR3BK59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate dehydrogenase (Cytochrome)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611555.1">
        <property type="nucleotide sequence ID" value="XM_066760251.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992657"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="96"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="5">
        <location>
            <begin position="193"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0242173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="61538" checksum="1DF13BFA1F19CC4A" modified="2025-10-08" version="1">MERTARMAIFRKGVQHAAVRSRYPTVNSRRAFGARRGFSAAAAENKTSDGYRRALLLGGIAATLAATISYTLLRPLHLKDEDLPDPSAPIGQATGRALIPYSEVNKHNKPDDCWVVIDGKVYDLTEFAGSHPGGSSPIYRAAGRDATAIFQPIHPPGTIENGLDPDAMVGLVDPATLPKVVDKNKEDGKQRRIDLAEIIGLPDFDEAAKANLTSKAWAYMSSGATDQYTLDLNRKAFNFILFRPRVLVDVEIADTRTQMMGQDTSLPIFISPAGMAKLAHPEGECLLAKAAGQSNIIQMISTNASAPLPSIISSATSTSQPFFMQLYVDRNRSKTETLLQKINSLGLKAVFVTVDASAPGKREADERSRAEVEVASGISGGKIGSDSKGGGIGRSVGGFIDPKLSWKDIEWLRQHTKLPIGLKGVQTAEDAMKAAKMGVDAIYLSNHGGRALDGSPPAMYTLLEMNKICPDVFKKCEVYIDGGCRRGTDVVKALCLGAKGVGMGRPFLYSLTYGEEGVVHAIEIMRDEIETTMRLLGVTKLDQLGPHLLNTKALDPLVFDQPMWGPGEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK83</accession>
    <name>A0ABR3BK83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611592.1">
        <property type="nucleotide sequence ID" value="XM_066760288.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992694"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="623" mass="68639" checksum="DA63B3E8A7BF721C" modified="2025-10-08" version="1">MFAAYQPLPSSENTYPPPCSEPPHQSLSRLLPWPPSEPLPGPPYPLRPTKSRFTPNHIIRYALAVTGGMIIFHYVIIGAFPNSTYTIKFGEKFTGYKIWEADEAYKAATASAENVLSHLNPSAGQPGTFFRDSFPIRSMLAFWELAEKEVAAKGLDTCNDQLGRGLVEGYHSSELAYCVPPGEGDVFEAVNTANISAGWDAASGEQVPASRISCSPVQDNDFTNWWPYPAAPCVSTNLRTIPNESRRYRAAGCEITEKGVKLTIGMGRETFLGAQMESVDMDDERAISGLPLEMLGLTSQHSFHVAEDLITTLVTLFIAARTVPFLVNSRVQLVFTEGYSMDSNHFTPLWDRVGAWAPRRLSLDPWQEGECLTNAIHSVGAGASLLSAMGVGKSYSCASTITWAASHYYRHLFGLLPPPVSSASTRSRARRPINVLWLSRAKLDHYAKEHNDWSSWRDIRHINNEKELVARLKDGLRTMCDQPSSVFGASGCVFEDARETPESWMSSSPDGLESDDAPLPVRFAQMDPSVQTIENQVSMVGHTTILVGSHGGALGLSLFLPPGSSTIVELQVSGVKGNYHFEHMAYEMGHQYEVMDIERTVDVDQVWESVQRWVEKIAAANGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKH8</accession>
    <name>A0ABR3BKH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611682.1">
        <property type="nucleotide sequence ID" value="XM_066760378.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992784"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF4">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="656"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="757" mass="84121" checksum="069CCC9AD0802DAE" modified="2025-10-08" version="1">MSFCAQSAPWTSDTETFISPANVADQLSLPPSTGVSNLCNHEQISSNGQSKIINENADRPKIKSSTFCKVLRIVAGLPAPVPKAFPKGKDRAPTRRPPVWAESRQELCEALPYYRSFQSGLYMYKKVAYGYLLEAFPAPRDTWADKGRVIISHGGGQCICPKLPDGTQGPPTLQADQSPTDARIETLLQAAERRTPLVLIAGKGYEQLPWELDCAYVVLGWYWISYTWVEAEPVGKGISPPRTRDYFHRYKIRFDWIKSQGEPWWHCESYLPLDFDILQKNRPTITVPQTLGCAGAHEEVVSGLRTEARLNTPAEPFLPVNSGFIMNSPGPLLSSNDLMQGDSLKDKITYRATESCGEWPGDKEMTSCLPVITDQTEELQIHLYDTFVCPNCHENTPLIYKEGQICVKPSCPAFFLLRTTCGLLPIPPGFSLTFNYPFLLLRPTPKPLENLPYNLVPSSIDENISEGAECEASLGGRALWKGWVCTDCKRANCRYRWEVWECRHCGNLFAPLGLDASMPLSSLSPNLPPFMGDAMTVNKGRIIVLSSTKNIAIAYDLPDAGTVYHVISHDRRVADKLFNDYQVEAARGFWFQRRALKVNTVRGTLLAQHFAINSGVPYKYNVDTLSVPFDQSPSCVLAALNLISSGTSDVLKAETRFNEILSVMYREGQKMSWHDDGEPGLGPVVASLCLGSPANISFRSKANQANGISCAEVTLSFILSHGDIMIMQGRDIQKKYHHRAMPYGLRIAATARMISDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL49</accession>
    <name>A0ABR3BL49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611885.1">
        <property type="nucleotide sequence ID" value="XM_066759939.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992339"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="476" mass="51890" checksum="269E1F6EEFB26BC9" modified="2025-10-08" version="1">MSSSPRPLPPPIPHHIPFKPAHRQSSSLSSMPSRPTTSSAPPMSTPLSRHSSFRVRSSRSSTRTGSPVPRAHGSSVRSKAISPVSPSRLPATDSVSYFPPFEDMGSVCSEGQGSSSGQSERGRACEREKEEGSRSRARSHEKKGSLGSIAGFVSASISWGLASLTYANTSQHSNYCHEESPIPDLHMSPAPTTPEEAVEALSRKFTPSKRRVLEPFTLKESIGPQTEDMAVKEKEKVIKGMHKRRMMSECEVETIIADTGYRGPEGKDDDEAIVERLLDDTRIAKHQTSAFNRRPKPAFRVRIPALPAWRYPMPSPPVTSLCPDIPLEAFSIAVDNPCSPMSATSSEIASTFMISEAKTHLEDAGRAKMEVEQVDCLAELQLQRELQPSISLVKHSCHTFPEPGQATPTKLQSSYPSCRVLKHEMYESSFPGEMAELKRIKSGSSTDSSDTIKPQKACQLAGLHGPTSTITAVMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLF8</accession>
    <name>A0ABR3BLF8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612004.1">
        <property type="nucleotide sequence ID" value="XM_066760058.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992459"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="7">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0243637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="138" mass="15609" checksum="B0DC4A6314C7A15B" modified="2025-10-08" version="1">MARTKQTARKSTGGKAPRKQLATKAARKQAPSQVSGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQEASEAYLVSLFEDTNLAAIHAKRVTIQPKDLQLARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLN7</accession>
    <name>A0ABR3BLN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612080.1">
        <property type="nucleotide sequence ID" value="XM_066760134.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992539"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="44891" checksum="1E5B2DEDE6E5C0B9" modified="2025-10-08" version="1">MFIYNVHTPSKTFALIHKEDESQQELLNRIYAKAGLKEEDKSKTGLVYEYNGSRWSLDDDEDLHILLSRYPPSSTPSVTLHLTHPSGGDTSGHSYTQSQSLSQTRGQAQGKARSQTGAAKSTGLDGTNQMLSQSGSNDGDVLPPAYATSPIAKTKSKGKSKSQAEKAKAKSVLDSNTRANAQNRDAGACFVHHGLEDETLSEGTAFLRPAPKARSEGEYHLASPVPPYTSNAPTNPVDRQNASSASAYEAGGAAERPKSRARSVYSTISRKSKYGDPDAEPLGDVKRREWHEFHGNNGVRTVIGKVGDVPNVRMLLKSGHRQIYISRQFAIKHGFLPKKFGAANGGFATSAHKAYVTEENKFDVILGRAWIEKMGVKIDPLDQTVLTYMDTGEPIACDVVVLKDEKGDIITIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLP8</accession>
    <name>A0ABR3BLP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612094.1">
        <property type="nucleotide sequence ID" value="XM_066760148.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992553"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="35"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0243727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="134" mass="14029" checksum="8AB60E8D1C41F05B" modified="2025-10-08" version="1">MGGGAAAGGDFDALLAQNQNGGWRGLFNNGRALGLACFASIGGILYGYNQGVFGQVQVMYSFEQRYTATLSNTDTKGLLTSILELGAFLGALMAGPLADRFSRKYSISAWCVVFMMGTAIQTGANSNVACIYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM37</accession>
    <name>A0ABR3BM37_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611013.1">
        <property type="nucleotide sequence ID" value="XM_066760741.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993163"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22268" checksum="3AAA8BCDE68E69DB" modified="2025-10-08" version="1">MVQLEQDEQTRMSSTADARDVAIMKHCIELSYNCEVSPTAFSVGSTLFLPSSSPQFPILKSRFPSFSKADSAETEGLILADGWSRQIPGNTHAEANALTNFRKVYGELLEGTDSTTNDLPPIENVLADVSCYATMEPCSVRTSGGPSCALELVRSNVNSVYLGVEEPPDFVRCEGVRILQNGNIEVISVSGLEEECLKAARRGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM49</accession>
    <name>A0ABR3BM49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611679.1">
        <property type="nucleotide sequence ID" value="XM_066760375.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992781"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547:SF2">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="675"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="974"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="1243"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1568"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1538"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1213"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1539"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1022"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0242297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1715" mass="189830" checksum="42242C854A5334E7" modified="2025-10-08" version="1">MKPAAFDHVRGVVQREEKNLCGHALGTDIDLSSVPTAFLEAYPFPAIVLVINASPRPRPPFLPEDSDATIRQTDSQISPLTGPPLQQFASASVAWGNQRWNDLTQGKTIAECVDVVSQNKLQTWVESNNGDKSESFALDMKSPEGLILHLAKTVLPSNPPSSSRSLCVLTSQYIDKSENVTPSVSSGDILFSPLSQFPQTFSPSSSFSSNPRRSIDVPTPLSEHRGSATSVTSNLRSSIYSTSPKSQFSPPTREQSTYATHRLAVREERPSRRRRRSPPNSSTRPKPLESHAQECWDLVENFDWSKTTLGPREHWMDALDPVLAITFESRTADCAWLGPDLELVYNNAYQELVDHPEAFGKPAREVWATNWDYLEPLVKRCLSGTPVYKDKDPLFWRRYGNGRLLEHYHTWRYVPITGKDGSVLGIFNQSIEVTDSVLLERRMSTTRELSEHMSFIRTTDDFFSSVADVFSQNPTDMPFALCYRVQQVDTDGTSVNLVVSLQSSVGVPEGHPSAPDQIPISFVNRNSYPNSAERPSSPAFSIVSIHSSSSHRVCHVSNDTTQWPIAKALQRRQCVIMEECSQLIEGYPIRRWDELPFSAIVVPICSERSSEIPDAVIILGLNVRRCFDHEYDSWIHSIRSQLSSALVTVKAYEAEQKMAEENARMEKAKVAWFRGAAHDLRSPLTLVAGPLADVLESDLTSSQRTALTVAQRNLDRLVRLVNALMDFSRVEAGRMEGRFVPTNLGQFVTQLAALFKPAIEKLGLEYVIDVQPREELVFIDPVLFETVVSNLIGNALKYTETGCITVRVQYTDYAEVSVIDTGVGIPKNELALVTEWFHRASTAIHSGTQGTGLGLALAKEFLKLHKGELLVESQTANQSGGPHGSTFTARIPLDFKPVPSAHILSSAESHKTFGKYSQVIADEAMRWVGSSDDFSETWDMPSTTGGSSASSGSGSTTTFGHKFADAFLFDKNDVVLVVEDNLDMREYIRQLFAPYCTVLEACNGEQAYNMAIQNPPNLILSDVLMPKLSGMELLQKIRCHPDTRIVPMVLISAIAGDESRVEALLNGADDYLAKPFKPKELIARVHLHMQVGKKRAKLEALYAQRETELAALSDYCPIGIFRGDKDGHIVYANAAWRAQSGVLLGDPNDWASYVHPDSKAQLLEQWDQWLKGDMKEFRAAWRWSNGTPVRSILVRLDLVKEGFSGLIGCVVDVSHEERRLIEAEERRKEAEESKHQQELLIDLTSHEIRTPVSAILQCSDLVKENLVSLKDQLRGAGPNGFVPSPELLADLEQDVEALESIYQCGLVQERIAGDVLSLARIQLNMLSLHDIDVNLRREGRKVSSIFASEAKMKDIDLRLVFGPTIEQAKILAIKTDPVRLGQVVTNLISNAIRFTSSSDVRKITIQYDVSFVPPANDSCALPSSIGLPDVLPAKENTPLWLFVNVTDSGPGMTQQELSVLFQRFAQGNKMIHTKYGGSGLGLFICRKITELLGGRIEVLSQVGHGSVFRFFIKTRAVAPPSAIAALIESSSPLKSISGSCPSPSVPMSRSSSRSTTVGTPIEDSGTEHVLIVEDNLINQTVLKRQLIKAGLSCNVASNGLEALNLIRETYRQHRRGGPNRKRLFDVVVMDLEMPVMDGITAIREIRASEAAGALNRNMVIALTGNARQGQIDHALASGFDDVVIKPYVLVDLLNKIKFMKIKKLELAAAKAQEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM74</accession>
    <name>A0ABR3BM74_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611878.1">
        <property type="nucleotide sequence ID" value="XM_066759932.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992332"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="138" mass="15244" checksum="7043D0221B3D4496" modified="2025-10-08" version="1">MSPIITHSRPDSSWTQRISGFFDPSKLSFNLRTAPRHEATSVYLAPHPDLPEDPFASRIDMAALLPEIGPLRDISKEYGPLAAATKECHVESRNDEEKVAVKEEQDPVEPGNQMPVGQSHNVTDPIGHLSKEKLPEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMB9</accession>
    <name>A0ABR3BMB9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105523</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611923.1">
        <property type="nucleotide sequence ID" value="XM_066759977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992378"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140914">
        <property type="entry name" value="PriB N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="299"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0243556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="502" mass="57461" checksum="D8D18B2321116B21" modified="2025-10-08" version="1">MFRATSRQTANTNSTPEVKLSKRNSTANGLPSARYSFRLNFYERPPALDITLEEFETCAISRLRVLSHIESLSHRSLPYSQVASGIATYAKMHLPLSSNTARNVNLDEERRRDEIGHWVLRLAFCRSPDLRQRFVRSELALFKSRFETDDKTERASFLKSLSFNYDTVDEDEKKLFKTELQQMLPKGSKEDAVSETWFKVPWYTVPDLVGARRVLVKGGLAFVPQSLQLSLVLQAFADRLEKALEFTAKNLPRLDEDERLGPVIDHLASSFLSGIGASDYQPTNELGDGMTVTADTIDDVARKHFPPCMRHLYEKLKKDHHLKHWGRLQLTLFLKGLGLPLDQAILFWRRSYGTSMTDDKFNKEYKYNIRHSYGQEGRRANYPPKNCQQILTQDQPGTQDSHGCPFRHFSPENLTAFLTNTYPDHFSRTSPEMRDVLDSVNASHYHLACTRVFEVTHGVKKGEGLGNGESVSHPNKWADRSRELEKEVIDGIKKKEEAMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMS2</accession>
    <name>A0ABR3BMS2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611268.1">
        <property type="nucleotide sequence ID" value="XM_066760507.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992915"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0241886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="157" mass="17771" checksum="ACE6FB2E3C135D62" modified="2025-10-08" version="1">MLFSAPISSLRIVVSTKDKDRLTKSETCGIPSTCRFDLSFHSICSKAQSARSNHWYRHHRTKYTLLSSFNALYISKIVSVAAAVEDLEKISKHDEPNQYQSNSIHRESYFARSDSQLSVLVQHLKASSHSCHPEVPATSRLYLLTDRLQPEPPLPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMT8</accession>
    <name>A0ABR3BMT8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612467.1">
        <property type="nucleotide sequence ID" value="XM_066758980.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991362"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1350"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1467"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1603"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1816"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="884"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1384"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1414"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1616"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1690"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1729"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1756"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1816"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1830"/>
            <end position="1839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1859" mass="200994" checksum="A48A9F30FCBF4C00" modified="2025-10-08" version="1">MPQSPNSQGLGITVANCAHPPSPLRISTTSSETGDQAPQGSVYGQRSPTKTRAGVGRLRVKTNDSVLQPTHSYTPLHSYTQSHLQSPTKPVAVISTSPPMCTSPTQPTPTATATSPPHSPSLDYRPASTSAATDGSGKGTVKSLRTSKPLGPRSSPGVGTSLSGRGDHHHLDRHDHDHPDHDHPESTGQSGQGLHVEVEMYRDEGGKHDEEEHEEDGGARLAPFRAPSSASVSTSFSASTHTSSSKSGKRKSEALRRRGAAAGKEGGKYMQLEGGDGDERGHEESDKSEREQRPTTYQPHAPAPVFARSPGQRTSNLAYPFPYPPQRAVPPHHYTTAPFFDPSYTTPRPYPDANLDGEIQGCEREFVRVRAKRMDRAMSAGGDGLRRPWSESTASDPAQPNPAPMKQRGRSLSDGADVLARQGTLLHPASGTQRSSEELGILLGGGRSRRLSRDKLLPPPCGRGEETTKVRLEASKKGRARVEVDVVVERECVVEGGEVRGRLEVRVSGGRGAEGLRVGSGKVRVVGFEELSTTRHIFYHQGHVLPLFDGGIPHTLSSSLFASPPDSDGYRLAAPGTHSLPFRFPLPLAAGAKGTYTPPSHRGPAVRYVLVGSLKTHIPATGKRSIAHFYRPIVVMPCLSPAVVLAPSIEPVEVYTEKGLGWSLRGEQGRVELRVAVGRRTWIKNLSLALLQDVCTFTERRESGAAADRGRPAETQRRKVAEEAVQGDFTSHGAGRVTGKGWWTGVEPGESGHWDMSIQVPAGLISIRRTKLVDISYTLRVTLNNSIYVDLPVTLISFLSIDPPPMPSGATGRLAEWAAVGKQAMHRQIQPAEIGHQPAQAQAHAPQDRHFPAARASSTTLHPDPSQPPVQPVHPLPSQPPVGPKSSPSTSTYTSPSIASLPNLVNSPGDAPNANSPHLSAFSTFSPHPPYQDPHLDLDLDLDLDLDIDDTHQDTISRAQNRAKGRQRSLMIIRAEMEREDQERRMSWAQAPWDGDGDGDGDADADGETQEMEGTYHTHTHLEHTPMPEPSSYLPNIEMSATAATDREKRMSIEELLEMEDQGWDFESADVHPTSHPLHLEHEQEQELLELVDEERQELENVISLPHPSYSHEQYEDAEDADHGDNDNDNDNDERDRDDESHAWGYDDEPALHSEDEDTGDTPTATPRRTAPHSPAFSTVSPKLAPEIAIETQATTETQTTVDQVDENDGKDQEGTREMGNDPSVQTHEPVKHPISVRLPPQLLPTPSPSTPVPDSALHRSPKKSPTKTIVRSGSVPSLRAKVSRETLNDRLEGVVKKSGIVPSTTATTAGRRVSVLSKRESMSSLAPVAEANGNGNGGVKVVQKKNSFSFATPGSPLKVKIPLSPAPNATSPRKTSRHPSPTKPNSIPESSSNRNFSPTKSPLLSKPMERASSDMSIKSQATNGTPTSQPPPLASPRASDSASSEGRWLESPRGKGEMQQLHFLSPVANGGGYQSFSPTSPHDGHEWGIVQQQKEQQKEQQTLGSPFTTCLSLHPPTDSVMSRLSLPHARSTSPFPSIGHHHGHHGPVSKHDTLPIPFDEMSIHDTPSSTLSSPSSCYSMLPSVKTKIAQMESREEALRKFSVSGSAMLSPPLSSKRDNSERQHAWGMEEIKENETDKESRNHRRGSQEKKTPVKRKSYTAALAPRTNRMGSQPINLSALRPSIPPRQTSASTTHSTQSTSSGSSYEYDPIYAPESNTRTPKTPKRLPAPALVSATTPTPTASPRNSIVSSGRLPISISPASSKSTTTSSYGDLMSTPKLDPFGLGYTSSGGMHGVGSGVSIAPIGGGLHKVDEEAVEREGLPRESSKRPVNTMTDSAEQGFKWNDYGEQRSPRGYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMV1</accession>
    <name>A0ABR3BMV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_104527</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612488.1">
        <property type="nucleotide sequence ID" value="XM_066759001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991383"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0245404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="340" mass="38578" checksum="65F568C7755F7736" modified="2025-10-08" version="1">MPPRKPKSRDVKSTAPSPSPSIVQRRSSRASRKEPASAVEVVEERDEVTSEGEETESEAKGLETMEADTGGAEQEEHVEEVAEKEQVKGKDRGKEKMSMAERMAKMKELRMKMDQSAAQNRRELVEDHQKAQVTAKELARLEKQRKLAQTLRLKAEAEENGEDIERKKNWEWTIEDNERWQAKLKEQKVKQDTHFHNAEDDAYKKYNRNLRATKADLVAYERQKEVALGLTPGTLVPAGATSSSLTASSSKTGLSGAEDLYRGADTLAYGDNKPSEDAVDRVISKINKDIGKKKRAKKDDEDGEVNYINERNKVFNKKISRYFDKYTKEIRANFERGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMZ6</accession>
    <name>A0ABR3BMZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rho1 guanine nucleotide exchange factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611358.1">
        <property type="nucleotide sequence ID" value="XM_066760597.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993005"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="657"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="881"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="1311"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1198"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1710"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1822"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1715"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1763"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1785"/>
            <end position="1808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0241976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1864" mass="209069" checksum="533097F2FCB3CB8B" modified="2025-10-08" version="1">MADSSGNSGDFGPQNGSATSASAARRPLPPQPPPRPALPPNPYPSYQTSASSSPTSLADRRIISSGSLGRRALPTPPLSSNDYSPSRSRALPTPPGGLPSGSYPDDPPPPPPPRPSGYATYTPREKPPLPQQPAARRMDSSPSPSPPSSRFGHSYESTAPSRSSSQAKSTADTIYTNRTSQSGHTNESPNLTLGNLNNEWLPMLERFGDLSTNFNDSLKAPSSRHINDGRYTPIQKDWRGPGDVDTAGQDRSAAETFSTLPTYQPSPQYDDSVMSRSVRKVNGGQGVPSNAWPEYLQPEARTGRDRSASAVTMKAGDAHDGAITPRGERYDKDTLFGPIAKDESPGEPQRQRLDTAFTGNGVPLSTPNTASSADSGPPKQPHRQNSSTSSLHPRSITSHNTGRTSFDLSPSWSHQAQTPSPWVERKLQIHQSHRHHSLADSFEHEQGPSGWEEEEWEEDEDEEIDVDEGQFFQPAFLSEMALQLRDKVERQRHIKAGIAWVGSFTGKDIVTTIHNLLPPHTREKPNDRRFALLLAQSLQNQLWFVEVDWDIKPLRDSSDDVFRFMGDMEGIASGADALTTELPKGLMTMATRCYSPSCTGDKRCYSPRCPYKTSPHTFLPTEESIIPLPTPVSGRHDDWKEDIDPLMLRDLSPRTITRQDVIRQALSSELAYEADLSIMEDLFITHLRLADPPIIPDPRRREEFIHEVFHNAHELREASKRLIEEFTIRQREQPIIQFVGDLFLQAATEFRNIYPEYTGSLPQAEATLSKELEENTEFRLYTERVVRENDRRRDIRHLITRPSAQLQRYPALLEGILNVTEPDDPDREFLSQALHSIQSISSLSQLKLFHASKGRGPASKLEWFDLVSEEERKTIPKKEQKRQMLIWELIQGEIQYVADLEVLGTVFAEGLRTAEPAVIDRNRLDVFLDEAFHNWRSLYEIHSRFLHNLQIRQLEQHPHIGMISDLVFDAALNWQEAYMEYVPHYPIAKVKVQEEEARNTKFASFLRVCLRDPMTNKQDIDHFMSRPIFRLLRYPLLLEPIRDCLKETAGPDDPDYEQIPQVMEVIAGLGKAIQKGVISNESKVELWDLQRTLDGSKISPRTVADLDLANPMRELIHRGIVYRQSEGSIGSGWTELNALLFDNFLVLTKLERPTKPSKSSRKEHRKERYAINRPPIPLELLSLGSFSEAPRVRNTGRLFGVGGTSHHDLPSDKSMNAPKTPGSSKSADTSKLYPFSISFIGGQGQLGGSYTLWADSFKARQDWREKFEHAKVLRTEINDAGKVFEMNPLSVDTFYMPPSYAMQKDKDGQYTGRVTCSCPFITQDQRRLVAVGCQDGVWIGIRGDSRSLRKVLHVKSVTGIAVLEEFSIFLVLSDKSLVAYQLEALVPSAGQKPVKTTTERISMPKEEISSFTVGRLDGRTLVVLMRAEATQTVFKILEPVLNKNTEDTARQRRPFGFLGKTSEWFRPYKMFYLPAEVYGVHFLKHKMAIVCSKGFEIMDLTDLKGGSIPIFDPAKIKEKPYLSDLERKCTQGKALGMFRSTETEFLLCYETFGLYIHRYGEPNRDCRPIEWQGRHDSVAFHPPYLLLISAPFIEIRHIDTGKLLQIYTGSDLRLTWDGSGGQKDPPVFNPGKHGYGDETKIQEPQIHICQRATDHKQGRGQQPIGQIVYELSPTLLLNNPLLNPLNTLDPNYLPPPPLTSHANPAIRQARPPSVRTMNSSDQSPHPNLYQNSNPSQGYISFPNAQSYAAQPPMPQRDSYGTRYSRDSSSHRDSNSVYNMTPIDPSPQSSTGAFSIQPQNHPSGYPSQGASGGLSYGQYLAQQPQIARGQSQGQGQGYGGYNDHAIRAWAQSGGHGRDNAYGGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN08</accession>
    <name>A0ABR3BN08_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TATA-binding protein interacting (TIP20) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612220.1">
        <property type="nucleotide sequence ID" value="XM_066759573.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991972"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0243853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1248" mass="135766" checksum="035E276B5D68D191" modified="2025-10-08" version="1">MRSIDPDYRIMALVDLNKELTRTLASQPSSIRRPDPHYTDDYTESQLVEMVLRLLADSNGEVKSAAVACISLMVKKPRPSSLSKIINSLLEDVSSDNDERRDTSCLALKNVVLEMPSESQQVLSDIERIVTRVFKLFTNEIHPQIASELLQILTDLFIRFSLNVASSATIQSTALSSLIQILDNARPAIRKRAIPTLSSLIATSPKLFNEDLEKEIVSGVSQGGESSRIWMGTVASLARGKSVGSIGKLVNEGKLAELILNQTKNEEDVETVEAALTALEALVLRCPSEMFPHISAITQRSLVLVKYDPNYVELKDEDDDDVDMTSDAEGDDEDEYGDADYSDEDDDSWKIRRSSAKLLRALIYTRPDLLSELYNSATPVLISRFSEREESVRLEVLAAFEVLLKQTATSRSTDLAAGGRNKRKRSEGMDEDYVSDDGPICSLQSYLPQLSKAILTQLSSKSVPTRQQSFNLLRQAATALGGGLDDSADPICAAAASALRTIDSATSSSLAIATLSFLAVFFDTHSARTFASHLGDLVPAIVRCMKDKLQRISFEAFDTASALIKSLRPAGSSGSNSGDLSTPIQEVFAATTEVLGDNSVDGDVREKALATLGNILVQSGDLFAFSFSTSLPLITNRLGSESTASTAIVVIGQLAASTQCKGPEFEGWLLQILPEVVVALRRTKRGTSKNAEFTCLLSIIERVGKALPVDLAEGLIIELTPVIDTPMALQTIALVLTHQPLARPAADAQLYPKILTTLKTSLNPHLVDALAEFFTAYAASLNSPEKAVKLVQELSNNLGSGKEDSLPDATSGGTAAWGTTAKCVGGVIKGEIASASESLTLFENVVKGKKVKETDAYLALLCIGEIGRIVDLSTKTDLFEIILSFFKHDSEEVRSAAAFAAGNLAVGAPAVYVPAIITRISAAKDESERLLLLHAIKEVILHSPSSELESLADTLWASLFSATDATSASKADSTGDDGIRNVIAACIGKLTTTVPAKFLPQLQQLLHSSPSNRATVASAVRYTFIDTSNGYDELIAPILVEFLSLMKDENLIVRRLSLASLNAALQNKPHLIVDKLDILQPLLYQGTYVKKELQREVTMGPWKVIEDDGLENRKTAYETMYTLLGTCFSKIDLPTFTARVLVSLSDVNEVKILGLMLLLRLGQVSPESVIPRLDEVVESLKGMMKDVEVKEDTVKQDLERKAEMQRSTLRTVVPLYKSSTPQQAPAFHAFVENLLTNEKWKEFRDYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN64</accession>
    <name>A0ABR3BN64_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612596.1">
        <property type="nucleotide sequence ID" value="XM_066759109.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991500"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="153" mass="17247" checksum="21B4B4BC0741D1E3" modified="2025-10-08" version="1">MTLDFDERNTPKALPHVFDLEPLAKHFEENPLPSGACKLIDLQGDDFLDTEDDSNIVAAALWILAVKYDNLPSEERPSDREASRKWLTKHRGDVIKRLTAKIEPPFHALNLDLIYKDVAGMLDELLAKTLPKGKREPDTKPQSTVCKALKNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN73</accession>
    <name>A0ABR3BN73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612084.1">
        <property type="nucleotide sequence ID" value="XM_066760138.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992543"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1224"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="540"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="604"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="695"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="816"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1275"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1300"/>
            <end position="1309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1309" mass="145982" checksum="456F50A4BEAD1F87" modified="2025-10-08" version="1">MDPDLDGIGFSLAKPDHVPKNPFESVRCMEPFLPSSPNATSSKYTHPPVNIAGSNSHPSATPVAARPYGMFPSLRFQKAHPLSQSILPPSSPSPSSASTGTAMAVCASSVAAPALPSATAPEAPSKNLTSQLPFGGPGRRFLPTKSGPFQTPTSPETPSSKSFSPVRTHTISERQSHSSLSLPCSMSISRRQGNMVMSATDASKETTAIENSHKYNRGWVEPPMKDTVRDDERHHREIREVDKGHAMDVEERHAYEPDSRDGRMEVEDKEPYESTIMQERTDEDQKNANDMDRGQQRRDVRNGQQNHPSQENSGQDEMEPSRHDQYQYELHEGRYTDSPPSQAAESNLRLLQHDAYNSSGRLGHGPSLPPNQEPHHIKYNFHKTPDQPPCSSSFGSLSNPKPAASSMSFLHGVSDHDRSGPATAMFKPSHLPLTKQHQTKDNDVSQGKPALSKAAAGLRVELNKEGGSEQMLLVMLQSKNGEINSLKDEMLRLQELMGFKQSANDGLAQETKRLEDLYRQSEQIWKTSISNAKKWRDTVKQKEMSKNQALKELKDSYEEQSQSYSETINSLSKELVTFREESMKKTKEDLKTHSTALANIRTALQSLKEDLTVHSNAVEELQSSKTRNVHLEDEIKAKDEEFRIARDQILELQDKLKTFEETIAPNLERMMSDMIQLKESASANPQALEAALLAQKELHEKLSEREQENLTLQRESQETRFSRDALDGQLGEAENHLRTLGCEAKHLKDMVQELERKHKEALQKSATKTEAVANEWKHKLELADLRVASLEQSLSSVKADAHLFAQRAIQTEMGIKTDLAARSSESQARINNLERELKVAMGERDKAIRSFDETRAREQMLKDKITGLTQSSKESQLQLQDVQGLLQDARKQGYILEEQVKSLSKQLGFRSQKSEGAMKFDEYFKHLQNKLVELQSAQGNTLELERVKAEVTHKQSCIQDLQKSLSDSHSTIGNINSDIRRLHLSIDQVTEENGRLKVEVEERRQSGQELVERWERDELSAEEVVMVQKVTQQIRRGEQAIYRQELDEKSNAVKKLESRCKKLEAQISVLSRGKMISSLTTPSALNRITHEPVSLFSSPFSNPPASSTAASHITVHSSSDPPNRPSAKSPSSPLAAVAVSHKPIIESAVCFASMTNSNFTPANSKKRRLLNSQDVDDSEESFGHDEIVDGIFATVDEALLDQPPLIQVPPKLQKKTRFAEIIEHSSPSPDSQPEDADDPIDPPTSQTQPNLHHLAQPPPSQVTKTYARNKGVMRTRSSLENVMANSANPSGATGHEKGTRKLRGGGKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN75</accession>
    <name>A0ABR3BN75_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RPA43 OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612238.1">
        <property type="nucleotide sequence ID" value="XM_066759591.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991990"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="6">
        <location>
            <begin position="130"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="359" mass="40669" checksum="9CA6DE4FBFC0200A" modified="2025-10-08" version="1">MSALNATASSSKQKKDKSKDKHNKEKHHNDKSKSKKDKKSKSEKHEKGEKSPFEHREMRMRLSVPPKFAGDVMAGVRDQLDGMIMQYLPEVKGVLIAHWDHSFDDDTAKIINECPFEVVNVEFHAIYWAPKIGQKLRGIHSISSPSHLSLIFAGAFNVSIPIQHIPADLYEFEETDEVVETKSDDGSEVEYIDQSEMEMEETGRWRNKKTGEFFGKRELVKFTVIGMQVTNQMLSLTGSLLEDPSNPPPAPEIIAAPIMPSPSPSPEPQQPHPAKKARTQPQPQIKQAVKDEVDTSKMTARELKAYRKEEEKKKRDARKARKEGRAEDDAEGEEQEEGGAGTKRKADEQESDKRKKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNB5</accession>
    <name>A0ABR3BNB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612637.1">
        <property type="nucleotide sequence ID" value="XM_066759150.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991541"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="1">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="198" mass="21851" checksum="366C48FF3413C1EB" modified="2025-10-08" version="1">MPDQYSAASASNPSLTQKLTDLRSLLSTQKTVILVTHAPNGRLHGRVMAIAEITKDWKFFFIYDRESYKEQEVDNDFHVNISIDAMAYNKGWASIAGRAKRINSPEVIQRLYNPTVKAWFADKGDGVHDGSANDPRVGALEVSIDEVRHFHQEKTVIGTVIDVVASAVKGETATPGDIRQISGEEIASAWAKGELKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNC5</accession>
    <name>A0ABR3BNC5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting 55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612651.1">
        <property type="nucleotide sequence ID" value="XM_066759164.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991555"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0245567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="13985" checksum="CFC0D2579E496DCF" modified="2025-10-08" version="1">MTAGLKTVILLSFILAAGFLLVILSCALWANWLPLLVALTFIIAPFPNWICSRCASADDLSPEYNSAYIDFGRFLTGMLVTTGLSLPLLLTHSALIQPTACWMSIAGGVLVYGTIMVYAGWFGGGSEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNG2</accession>
    <name>A0ABR3BNG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipase</fullName>
            <ecNumber evidence="6">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611805.1">
        <property type="nucleotide sequence ID" value="XM_066759859.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992259"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="8">
        <location>
            <begin position="1076"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1166"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1246"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1305"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1493"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1177"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1310"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1348"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1513"/>
            <end position="1527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0243438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1638" mass="183958" checksum="E8EA3DE1D98D6C50" modified="2025-10-08" version="1">MSQQGRDQEEAEGRGSSQHEKFIPDSFDKHVTECPVEEHGGSPSSSIPRSLTSSVRVIRIDDSAKSSSEQQSVDQPMGRSPSIQKQIPDEAGRSPNQLPGMKSEDKPGPMNEIYLEPRITHIHYHEHLEPTVRGIRHGPILNITPDGEAELPPGETSQSSRRPSSNHISNCMTRNSRDSNDFSVSASNGDVPDGIWRSALQQPGTGGKDKKKAASSRFSSFRGDEVTTGESDAEDSGPGTPTEAAQKRWSMLRHRILPSRTSFGGNPTGPTPGRVSALAPTVIASVPLTTELFAGQLPVMILKSWIDRDEDGRKAVPVLLGNLRFRVGDSVGLRQGKEATGKEMFKVECEYGDGAVKWVIFRELRDFLSLHAHYKAANFGTSVAGLRSTRRVEIPDFPRMSIPYLNKFERTPGGKDKEKVKHIGKAEHAQASRDALQQYLVELIRAVIFRPESNRLCKFFELSALTLALAPRGGFQGKTGFLKIPGSNVSRRANQPGLTPQSWKASKEPKWFIVRDTYCVATDGPETTDFYDVFLFDSDFTIIRPKRYYRQGINILSGHAAAKHIKLKNGSDSNNNISIPERVDTDNPFNREVIVRSGEGQGSKAQNMHDETEHEASQHTFYIVNSQRKLKLVAKNARQMHQFIVSMERIASQCAWTKRNRFDSFAPLRLNVAAQWLVDGRDYFWNLSRAINMAKDRIYIHDWWISPELYLRRPGDERYRLDNLLKRKAEDGVKIFIIIYNEVSDKTTPVDSQYTKRTLMNLHPNIMIQRSPSHFQTGTFYWSHKLCVIDETIAFMGGLDLCYGRWDTPQHVLIDEEFSEPDGPNGPVWRGKDYANERVMEYTNLDKPFEDMFDRTKVPRMPWHDVGLQIVGQPARDLCRHFVQRWNLLIRTKNHKRRMPFLLPAADFTGRELQDLKLQGTCEVQICRSVGPWSMGTSTKIEHSIQNAYCKSIETSEHFVYIENQFFITSTIVGGVAVENSIGDSLVNRIIRAHKEGQDWRACIVIPLLPGYTYPLDSNEASSVRLILECQNRTICRGTSSIFSRLRKEGIDPDDYITFFSLRGWSKFKTGVLTSEQVYVHGKTMVVDDRLVLCGSANINERSQRGDRDSELLAVIRDTDMVDGIMAGRPYKVGRFAHTLRVRLMREHVGVDVDALDEEHLMSREPIAEADEVETWDPDHEQQSENEGRDGITQVKKRAARERLMNTFSAGLASLTKGMSENAISSVKKTADKLVHPAAVIASGQTAAHHQLNVGDPSEREDYEPEGETSKGFASSVVPTLEEKTIFERRQSAQQANGRPLFDLQEERSQQGGQDVSQTKSKEEREEASETNVPRKTKEHTTLFDGDSTAQKPSVPRSQIESSSKELFGTPANIATLNDDLPVRGTNCPAEGEGKGTNEGQTAFKARKILRKHLNANVQMSPWSMPAPTPDINPNSFHDPLDGRFWKNVWVATAVHNTEIFRKVFRCVPDDLVTSWAQYKAFANHAEKFNKEPEDVAQEGSDEPVKVTHDGPGTHGAGGGGSGGGQVGTMLRDKESNESETIGPDVVDGKPRDRLGLGTEGTRNTINGGELKMEAERDKRPSQPDEAWAEWERYEMEKLLNEVRGHLVIYPTRFLEAEDLANNFLFNSDKILPLPIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNJ8</accession>
    <name>A0ABR3BNJ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="4">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611850.1">
        <property type="nucleotide sequence ID" value="XM_066759904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992304"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="5">
        <location>
            <begin position="86"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0243483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="158" mass="17268" checksum="0916769E8A593726" modified="2025-10-08" version="1">MAEEEHHETFEATGAGASKTFPMQCSALRKNGHVVIKGRPCKIVDMSTSKTGKHGHAKVHLVAIDIFTGKKLEDISPSTHNMDVPNVRRQEFQLLDIQDGFLNLMDSDGGSKDDVKVPDTEIGQQISADFEAGKDLMVTIISAMDEEQAISYKEAPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNS4</accession>
    <name>A0ABR3BNS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_105314</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612418.1">
        <property type="nucleotide sequence ID" value="XM_066759771.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992170"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="196"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0244051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="339" mass="36846" checksum="FDD2471D52D6A232" modified="2025-10-08" version="1">MDSSLSLPPALSSGITLSSAHALSFLFTTSYVSSLYISQHLFGASAPNPKKGPPPRTAHSHTELLPPISATDADGLGVEHDLGPELGSRDHPITIKRRMKAVACSTFLSVGGVCYVVKHVGNYSWKEAIRPTMALLGVPIGFAMPSRVLPYLLTPGLMVGPLYAMYLSGEVPVIGWGKKGESLCSTVKREFSLVEVRNYIVGPLTEEVVFRSTVLAVSLLGRLPLKSLVFGTPMWFGIAHAHHGFEMYKKNGRNGAAALQAILTTLFQLTYTTLFGWFASYLYLRTGSVLPPLSAHVYCNVMGMYLPTTAIKRYPRKKTLIWGTYLAGIVGFYFGVQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNU6</accession>
    <name>A0ABR3BNU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104865</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612814.1">
        <property type="nucleotide sequence ID" value="XM_066759327.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991721"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="72"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="572"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="753"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="717"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="540"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="595"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="782"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0245730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="802" mass="89479" checksum="26F262CE4F9C4CB0" modified="2025-10-08" version="1">MPKPKTARGILLTSNLPQLQNLIKRDPEGYKEEFLTQYNHYLSLLRLHSVASSTPSSSNDKSNELFADLITFISQVAQCYPEETKDLPIQLSGLLLGGESGTSNAVTGDLRKTAVKNLVMLRNKEIIDSIQLLQTLLPLLPTVPSTLRSIIRHTILTDIKTSNAKTKNHRLNRVVQSLLFGMVESGMGAEVVGDKGRNKGKGREKGGEAMWAVMMVKELWRKGVWTDAKTVSIVSLAAFHPNTKMQSAALHFFLGSENEDEDDSDDEDEVGEARRDVRKMEHRMEVSRGKRKKEKQVKQLKKEASKKRKKRAEGAGATPNFPALELLHDPQTFGEKLYDNLHKHDKIYSLEHKILIMQLLSRVMGVHKLCVLGFYSYIIKYLTYHQLQVTLILVSLAQSVHDLTPPDVLTPVIRKLAQEFVHPGVGAEVIAAGLNAIREVCRRQPWCMEEDLLGDLIEYRKSKDKGVVTASRGLLQLFREVNPGMLKRRERGKAASMGLIGSQVLAYGHSADAAEGIEGLELLEEHYAKLRKEANGGVSDESDVEMEVDEDDDEGWEGWEAESDSENDSDGWQSVSSGGEDLEISDSEDESDKKRDKKDKREKKRLARGKGKAKDEDEESDEDEEMDDAVSVAPTEATEASQTTKKLSLLAQQKILTPADFALLNELRLKAAKELAAAGGGSAAKRKLAALEASKRHVGEDEADRFLTEAEILGPRKKAKATWEERMESIQKGREGREKFGSMKGKKKKAAPSSSTNKEKAKNKPIMMALHSNKVVSKKKASLRDKQIRLRAAIEKRKKQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNW6</accession>
    <name>A0ABR3BNW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612851.1">
        <property type="nucleotide sequence ID" value="XM_066759364.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991759"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="76" mass="8454" checksum="2512E25F8C7E0423" modified="2025-10-08" version="1">MNFSTGRTAENDQPMQSNNEEDEFASGEITSEERTQLMAEVSNVEEFVKLRKELGYDDAGAGLQHLLACSQSSSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNZ7</accession>
    <name>A0ABR3BNZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidylprolyl isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612887.1">
        <property type="nucleotide sequence ID" value="XM_066759400.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991795"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0245803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17823" checksum="0B23236B302CF7FD" modified="2025-10-08" version="1">MNAQPPTLQEPLDIEIKIMRSSSSAKDKEEKLKAKRKEYLKKSDPATVEELLGGKTLEKDYFKEGEWKPSWAHLEFNGDACLDNVSKKSSEGFYVPAGTILPLGASMQPMTVVKYGGYFPEGTSFPGGVLVPMHARMVNLLPKETTKPASKLNEESLCTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPB7</accession>
    <name>A0ABR3BPB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612994.1">
        <property type="nucleotide sequence ID" value="XM_066758546.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990922"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="236"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="303"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="100"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="411" mass="45568" checksum="00EA223D80D17AC1" modified="2025-10-08" version="1">MADYLGRPSDGDSPFAIGRRAMRDTSSPQPPQQRNPAPRNQYPQPPQQQAQSYGAPLGVPMRGYAASPGPGGRSGMASPGPGARSGMVSPTQGSFPPQAPLQQQQQQGQGSYQQSQRQYSSPPQQQQGFQPQQYQPRPQYGQLQQVRSQGYGSAQSPISPGTASNHGYPPVGSSGSGYTPMQQQQQQQHYDQAPQQHPLYATSSHGRQSQQAQQGQWGPQQHVQTVSSTPPMLSTADNAELRDMFTAFDSSRSGHLSAFDLQKLLAKDATMDAREDSVKMLMNIFDTDRSGSINFQEFEGLYRYIQDWHGIFNRFDRDSSGLIDRTELHSALMGFGFPLPPEMIRKIEKRFTPPPVPGKDAPRGISFDRFLMACVTVKHYTEGFRRVDQRKEGKVTFSYESFMEMVLDAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPD0</accession>
    <name>A0ABR3BPD0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613011.1">
        <property type="nucleotide sequence ID" value="XM_066758563.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990939"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="668"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1056" mass="113238" checksum="D317F18E746C4B28" modified="2025-10-08" version="1">MAPIALTSSATSPPGLPVKKAALATADVNAGLNLDADGASTPYSATSTAVSEGENKDKVSKPASPSALAKALVDSSIPSPLPLPTDDGYYTNLIASSLPTASTKPGTAVFASAIDGLEALAVKHSESVWVYDDAKLVGFGSRLSKLGNKKVHELQTRQGAGLELAGYASKTQGKFTVFASIKTLQYLLPSLEAIEGDVVINLATTSTTDDLEFTDALYAPGTIKALTSLPEGWEVVFSSGERIVDNASKLYGAEPKKVIHVVESTFIGRETTSFTFPAPQPAAIDDLTVHNGSASELYVAPAGYLSSSIAAALPASAGLVELNTLSASSEALYAALTSSERKTVQVVGASKVDAEALKAVVLASIYAASGSSKNVLPLVKSLVATSVESISAFAQSTATKPGKIVSFYTAPACPLPQLLAHLFLSSPSLSTHLAQFGSASARGVKSVLSLAPAGTSRAALNVEEPTDVTWISDANVLKSADVLSVAKEGSIIVLALPWSEEEIPVKFTRSEIQAIKSKNLRIFSLDISSSPTTPIQEQVAFLLLYTGAQKLAPGVWKVLDAFHNHQLVRDDVEIAQAALNEVNTKGWEVPELEEGKTEKVKSKWEWDALPGLAGVVAAHDDQGSSVGPWELAARHLFFREAFTVPDAATTDASQGLPGITALRPSMSEDTFLVTVSENRRLTPVSYDRNVFHLELDTAGTGLKYDIGEAIGIHGWNDTEEVREFCEWYGLDPDALVTFPCPTRQGTLETRTVFQLLQQDIDLFGRPGKAFYAALSKIATVKAEAMRLKFISAPEGAELFKRLAEDITVTFADVLKMFKSARPGIEELVGLIPEIKPRHYSIASSQKAVGDKVELLIVTVDWINSKGSPRFGQCTRYLADLKPGAKVTVSIKPSVMKLPPDNKQPIIMAGLGTGAAPFRAFMQHRAWQRSQGIEVGPLIYYFGSRYRSQEYLYGEDIEAYIASGIISHAGLAFSRDSDSKTYIQHKMSQDKNMLAKLLKGKGSDAAYFYLCGPTWPVPDVYEALVGSLTQEGGMERKEAEEYLDELKEEERYVLEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPI3</accession>
    <name>A0ABR3BPI3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613062.1">
        <property type="nucleotide sequence ID" value="XM_066758614.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990992"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF76">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="170"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="504"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="635"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="757"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="843"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="684"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="769"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="843"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="891" mass="95629" checksum="DAB52D276D119B60" modified="2025-10-08" version="1">MLHASNRPPPPSHAPPQQPSTSGIDSAASSPKQSPASLFIQRLHASRPTGYETASNSSRGAESSAQGAVGAAELGGMAGLRGRGGVSFASRHPLFSHHAARARPSSSSPAHSISPSFLSDPGPSGPPSPSISDLSSSAFSPASAFLSHFSSSSSATQLAPDAEGARVKDYTLGKLVGRGGFSTVRKATLRSSGKVLACKIVKRDDLSDKTGSVEKFEEEIKTWQNLPPHPSLLPLLDMHRTPSATFLFTPYLPGGSLLDVLNREGGSDKTARKWFPGVVAAVSAMHEGFPGFPGGLLHGDLKLDNFLVDHQGKVMVCDFYMAQMVGRQEDRPATIPPPLTAGVNRHSTLPSNFSRGSSRMPSPYRSHNSHTPHRFPNEHHLHENSHAPSPSHNQSFPSASLPYAPPELLRAPPLRPSLAQDIWAIGVVLHALLTGRLPFFDPFDPRLQMKILRGTWDEPPNLGKEWLECLKGCLDGDRERRWTIVRVKGSDAVLGWKEVQSRSKSRSRSRVRIGRSIGMGDGFMDPTRRDGVSQPMPIMSSSSRNPRGKKSASVSRSRDRGHSFHGGVFPGEHTRTPFAHPHHHHHALHLQDPPLPPRSRSASASRSRSSGHLPIFTFDAPELSRNLEQVDLNRGRSTHRGIPPGAIWTPSVPASNSSSSSLSYARPQVATPSNQGTPFMIQPADASYSGAASRSRSQSANKGGGMLPQLSPIWPSGFKGAMGMGLTESGVGTGGEYGRPAGPAAGVGVVMPIPVMTPNVKSRSRSRRTQASTSPSVSRSRSQARDSPSLSVGGGSGGHMGWGETLHTPWAETSPAVTPGLGGTPLTHARWNSPQFERYEYGQELGAVHEEDRGRDRGVRSREASMNREQRDQSRGRKGRPVYRAGESFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ79</accession>
    <name>A0ABR3BQ79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613015.1">
        <property type="nucleotide sequence ID" value="XM_066758567.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990944"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37550" checksum="06B8FD5E17A7F006" modified="2025-10-08" version="1">MSPIAIRFLYPPSSGHPAGAKSQTHITPRIVLDRSFILTSTIALASPPLSPSSTTPSDAGIQTPQTDVSFQSAQSRKRKAVNVANGFSPKARCVTIKPLFRPILERCAAYDPSVDQSTVRPTHSAGLANGEQHYLHPYSPTSDWGNHRAAKPSREEKIRDERLAKMKKMNKDEKKARKEGITRTQELVKELKANAKGEVYVRKGSEEVIANNTPSVGTPLPSGTPVSGTRGTRGGKVKTSPAAQSDTHTSPTTNSYSTRAKTYSPPSKESALQPEIVEAPQTVPLASGKIKPGRRKATAPEASVSLRERIYDQSDGFVRSFCYFTVIYILRPISVTSYRPLRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQL8</accession>
    <name>A0ABR3BQL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenylosuccinate lyase</fullName>
            <shortName evidence="2">ASL</shortName>
            <ecNumber evidence="2">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613108.1">
        <property type="nucleotide sequence ID" value="XM_066758660.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991038"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="3">
        <location>
            <begin position="370"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="479" mass="53701" checksum="48F399C0EB596E3C" modified="2025-10-08" version="1">MDSYQTPLSSRYASKEMSKLFSSGARFGTWRKLWLNLAIAEKELGLAISDAAIEQMKANLELDEAQMKVAAEEEKKRRHDVMAHVHTFGTVAPEAAGIIHLGATSCYVTDNADLIFLRDGLDILLPKLATVISRLANFAKQYRDLPTLGFTHFQPAQLTTVGKRATLWIQELLWDLRNLQRARNDLGFRGVKGTTGTQASFLALFDGDHSKVEALDKRVTELFGFPYAYPVTGQTYSRKIDADVLGPLSSFGATVHKIATDIRLLANLKEIEEPFEKDQIGSSAMAYKRNPMRCERACSLARHLMVIYQNTLMTSSVQWLERTLDDSANRRVTIPEAFLTADILLTTLQNISEGLVVYPRVIGRRISQELPFMATENIIMAIVKAGGDRQECHEKIRVLSHQAGAVVKEEGGENDLIDRVKKDEYFKPIWGQLDALLDPRTFVGRAPEQVDGFLKEWVEPALKPYEEALKNVKTAELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQP0</accession>
    <name>A0ABR3BQP0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613306.1">
        <property type="nucleotide sequence ID" value="XM_066758858.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991237"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="115"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="590" mass="64641" checksum="5A8CFF8F166B2EA8" modified="2025-10-08" version="1">MSKDAQAVISLAHPSLNQPQQGESQASYQPSTTTTLAPDVESKAVPTSNTSSLKADIFSNDAKNDKNGEDIDGENDTFRMSGESGVGIPDEKEAQTPSHHSGPEIKVSQRKKWGLLALFSVSLVIDQWCLAAFYILTSPIIDSMQVPFAQQSWVITSYTVTFAATLLFWGRVSDLYSAAPVFSYGIITLGLLNLIISFLPERYSFFILRALSGIAGSSSVPSAYRLIVAVFEPHELNKAFTVYSMSGAIANSTGNIIAGTIMLIPSGGQGEAWRWFFRILSVILLPVGVWSIFWIPRSRGENADATDKSARMDLPGCFMMLVAIVLLILSLTLGASNGWSTPGFIAPLIISAIIFPGFFIWESRIKPTHALLPPSIWRYHDFTHWIVFALLGYTWWSVNFFAFIEYWMDYMGEKAIIVSLRVLAEGITPIIVAIIITKWGRLMEWPRISITCGALLGIAAYIMFILSGTHVGRDYWRYIFPAMIFGATGMYLVFTATSVGAMCAVPANVGGVAGATLQVAYQVGAAVSFAVQAGLFTVNEGGISNFDNIRASFYFEIGFIALWLIGFLVFYRPPKNTEVSGDKERIVAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR84</accession>
    <name>A0ABR3BR84_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613658.1">
        <property type="nucleotide sequence ID" value="XM_066758256.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990631"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="69" mass="7575" checksum="6CFD77ADFC1C7CC2" modified="2025-10-08" version="1">MSELCSLAGWKSNTDTLKPCFTVTHCISQNAEPGFLAELPPRDINNYCNRSDAPLQIHPVSTFLSQPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR99</accession>
    <name>A0ABR3BR99_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613673.1">
        <property type="nucleotide sequence ID" value="XM_066758271.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990646"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="104" mass="12160" checksum="504088C1E63B3487" modified="2025-10-08" version="1">MAAGKQPATLEELSKRIIYSDRYSDDRFEYRHVILPKQMLKLIPKRYFASDDSGLLRILEEDEWRGIGITQSLGWEHFEVHAPEPHILLFRRPLPGSNANAKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRA0</accession>
    <name>A0ABR3BRA0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612780.1">
        <property type="nucleotide sequence ID" value="XM_066759293.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991687"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="370" mass="40026" checksum="0287E395CD989B14" modified="2025-10-08" version="1">MSDNRQDAQRELHTQVEANIEDSLGSALGSSFNIPPPPPKNEAPVSSQEKESAHAPAASAPVPGLDEWPQTLQGYLDEWQAESAVARAKAEATRKRFEEERAAEIKAVEDAKKMEKKNKEDEEKRKRDAERLRRELEGEEDEVHGGKGHGHGDKSKVKEAWELVAKKEEQSKDTPVVETGARGVNSEDVRTGQVRAPIYDPTTSTDPIPPIFQDPKPVTPAPAPTESATLSRHSATSQAWEEISGRSSGSGEQVSPPRSSGSDDIVQVPSNPEKALETPLPPTQPPSLTLTLFTNPSSLSIPRIFAVIGINLVLPFINGVMLGFGEIFAREVVRVGKAVWRGERSLFNWGRGSGLGGRGTTGVGLRGTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS33</accession>
    <name>A0ABR3BS33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103073</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613958.1">
        <property type="nucleotide sequence ID" value="XM_066757574.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989929"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="162"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0249771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="404" mass="48161" checksum="7A02695542703B63" modified="2025-10-08" version="1">MSQRHKHLHRRRASSVTVALDQIPLNHSQQSPSPEPEVRTLPGSRRQTDRDRYRSKGLWSDIKTGRWLLAPAASFKLSLIAPSFYLIHHLLTTYGIINHAQVPNVFEHFVLPSNKLEDGRYGKSWWDFAFLANYVIFWTFVRQFVTVRVLRPMAKALGVKGQKIVRFTEQGYAVFYFGLLGACGLYVMHDLPIWWFKTKHFWLEYPHRKMTFQLKTYYLLQAAYWLQQTIILIAKIEKPRKDYNELVAHHIVTLWLVGWSYTFYLTYIGVAVFITMDVSDLFLGLAKCVNYVSEFYSVPLFAWFTIVWTYMRHYLNIVILYSVWAHFDLIPLPDRTTFDPLNDQWIDWWMKWQIFTPILLLQVLNLIWYYLILRILVRALFLNDRRDERSDNEDEVEGDEVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSE9</accession>
    <name>A0ABR3BSE9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613569.1">
        <property type="nucleotide sequence ID" value="XM_066758167.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990540"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="239" mass="26728" checksum="E7E8B3E701C2ADA0" modified="2025-10-08" version="1">MDPNSIMTPATGAISSRFESQSAIDEARENRKKEWAEAYARIGQEPPPEEPETDYDARTLYERLQAQKELKQEEWDSKMKLSNQWRGLNADEQRFLAEKEAEKRAEQKKLEEREAEEMRAYRERLAARNTSQADDSPPTIASIAKPAPPKKVPSKDVKKKDVKSLMKGVVVKKKPKAPVAPSTNKPFTAASEAAGKPDLPSSKPSEPEVDNKTGTKREAPSDVPDAEDGKRQKLEEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSI6</accession>
    <name>A0ABR3BSI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614108.1">
        <property type="nucleotide sequence ID" value="XM_066757724.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990080"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="13"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0249921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="175" mass="19561" checksum="05DA70B8CBD291D8" modified="2025-10-08" version="1">MFGNNSSRSQSSTATRRLMKEYRDLTADPLQDTITAGPISEDNMLEWEALIQGPEGTPYEGGVFAAKLVFPSDYPLNPFTMTFDPPLLHPNIYPNGLVCISILHPPGDDPMQYESASERWSPVQGVRSVLLSVLSMLAEPNIESGADIECCKLYRDNKPEFERRVREQVKNLLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSP8</accession>
    <name>A0ABR3BSP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lupus La protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614156.1">
        <property type="nucleotide sequence ID" value="XM_066757772.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990128"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="30"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="134"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0249969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="56883" checksum="7E4A6D290822EABB" modified="2025-10-08" version="1">MSAEQVAASIPEESKEIELGPLPSVEGKSEDEVKELLGKAAKQVRFYFSDSNLPVDKYFFSLTCCNAEGWVPIKTISTFKRMKDFESLGVPFVAYALRLSIKEDGNDPLVAVSEDGENVRRKRPLEKNTTAWDRSVYIKGFGEEETEANTQEKIEAYCDQFGKINAVRMRRGDIEGKGAAGKGKGQFKGSVFVEFAYEADAKKFAEQESIPKFTSDGPEMTFMSKDAYVKMKAKEKGIPEGDINRGGQSKSRPEGKFNAFREMEKAKHGQLPSLAKIPDGVAIVGSRPEVKNLKAGENKKRSREDDDEEREGKEARTEEPEPLVIEYNGASLECDRHTGKVLDRSKVAFEINSAVKFINHGENPDWKDLKAQVSNVIASPFLAFPPGSSSGTIAKSDNSVINDEEFEKLKDAKMTFGGAEVEWARMTEEEHRDFWYTRACFKGKQAAQALNEKEEKEKRGRGGRGGRGGGRGGRGRGGRGGRGGRGGKGGRGGRDRGDRKEDNQAGFPPKLATGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSR8</accession>
    <name>A0ABR3BSR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614011.1">
        <property type="nucleotide sequence ID" value="XM_066757627.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989982"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0249824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="54718" checksum="B6DDF125379A6CBD" modified="2025-10-08" version="1">MGLLSQKMDTLSIRGKTSRSGSVASPTGTPVKDTETQIDDGDPNDTSTLDQEEGNILMAIISQLRPGMDLSKIALPTFVLEPRSLLERITDFFSHPELIFGVGNESDAKQRYIRVMTFYLSGWHIKPKGVKKPYNPVLGEFFRCTYVYPDGSEGFYIAEQVSHHPPVSAFFYISPKNGLLVTGELKPKSKFLGNSAATIMEGEDRIRLLDRPEDGEYSITMPNTYARGILFGRMLLELCDVSSIVNAKNDFHCDVDFKAKGWISGGYNVISGKVIGPGKSDIGDLSGHWSSAIEFKDKETKEKKVLFDPSTSRIAPKKVLPESEQEEYESRRLWTKLTDAIRAADMHGATAAKSAVEDHQRELAKKRESAGGAAHEQRFFKHVAGDKWMPKLDIDNLPKDRTEMEDVVRKWIFGDKNPLDYESAKATPRVSQSAESGATLSAAGGTTAGAAGIAGANVGADVGSSNASVNESIRSTSTEPPAAPTAPGPPVGQPIDHPIPRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BST3</accession>
    <name>A0ABR3BST3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uracil phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614192.1">
        <property type="nucleotide sequence ID" value="XM_066757808.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990164"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="231" mass="25508" checksum="2DCA626DC0411A43" modified="2025-10-08" version="1">MSTNITTCLPASGSNVHKAELPGNAFVLPPTSQLQSLLTIIRDETTQRGDFVFTSDRIIRLLVEEGLNHLPVLPKKVITPVGREFEGVAFQGRICGVSIMRAGEAMEAGLRDCCRSVRIGKILIQRDEETAQPKLFYAKLPDDIAQRYILLLDPMLATGGSCIKAIEVLLDHGVQEEKILFLNLIASPEGIKKVCTRFPKLTIITAWVDEGLDDHSYIVPGLGDFGDRYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSZ4</accession>
    <name>A0ABR3BSZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear segregation protein Bfr1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614255.1">
        <property type="nucleotide sequence ID" value="XM_066757871.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990229"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="434"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="61345" checksum="0FD1E24396D664AE" modified="2025-10-08" version="1">MPPPTSSLKPTSAKSVTDAGSGAKATGDKKSSGQMAKPDQSKYNAEQDEINKEIAAVKEKIEAVRSRIALSQAPTSNDRRSAIKAELDGLRSEQAKFKGDRNKLFEEMKRLQEGVQKKIKDVQGQRNKMGFKSVADIDARIASLDKQVESGSMKLVDEKKALQEITTLRRSRKTLEASGSIDESIAADKAKIDELKKQLDDPEAKKVSDRFDELKKEMDGLREEGNKAFEERGKLFDERNKLSAEMDELYDRKRKSAQKWREDNDKYYAKIQADRQVRQERFKAEKAREDAERREQEIARLREEARAPAFASETEDCGVLINWFKGKYGSGEVPSTHAGGKPDSATVVEGVKALEIRKVDDEAFKGMTLKKKDDDLDGFFGGSGKSKKRGKKGNSGTATPASQEGGNSAKEAVNLPMSLLSTLLSLGISPPSGKDDVQRTVDDLEKKKAWFEANSAAKTKAEIERVEKLVAKMQKKNGAAFEPESEVDIPTSADETQVKGGVHEPYHTVAVSGEATGPEEVQEDGDQLPQEDDEAGEAEVKKVDSALEEIREKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT05</accession>
    <name>A0ABR3BT05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614264.1">
        <property type="nucleotide sequence ID" value="XM_066757880.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990238"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14504" checksum="03A65BD80590DB3A" modified="2025-10-08" version="1">MSSSPTPRPSPLSNSRPDRRPVNPPPRRPIPSPNVPTPSALASEPLASATGSGWAATRAALARGRTPIPEHVKSRSIWQSYLSLSGNARIMFGLALGAVAIAGLLWDRQVTEDEPKGEQEQKPLINVRMVDRPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT26</accession>
    <name>A0ABR3BT26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614291.1">
        <property type="nucleotide sequence ID" value="XM_066757907.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990267"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="23"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="240" mass="26236" checksum="B6CB658647ADD6BF" modified="2025-10-08" version="1">MSCSHEAHDHDHHDREHDGHSHDVPLESSPLDSLYTQVDLSGVTALNAEGGGEAGRKVIKSWDMKEDDTIWLESEVDDELILKIPFTSSVSLRSITLKSGPGGHTPREMHLFRDNLGLDFSDASSSSPTQSFDVVPRKEGVEYQVKAAKFSGLTSLTIFFPGNTADDDEETTKIYYIGLRGSWKPLPNRPGIIIYESSANPADHKIPGVNAGGAGVKVDGSRDIYYLVVFTVISSQTGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT29</accession>
    <name>A0ABR3BT29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Endopolyphosphatase</fullName>
            <ecNumber evidence="3 12">3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_103419</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22452"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10" evidence="3 12"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614299.1">
        <property type="nucleotide sequence ID" value="XM_066757915.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990275"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046774475" description="Endopolyphosphatase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="470"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR027093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0250112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="676" mass="77629" checksum="FA6EC74CA95A9747" modified="2025-10-08" version="1">MRSPLVASLLALTLSIASSAAISSTEQMPLNVSFSQLDNSESQDVRINKKRPLKGRFLHITDIHPDPHYKAGSTFDSGCHRKPKKDKKVKSRATENEMGNELVDDENLDTLKKTEDLAGKWGTAVSDCDCPMSLVNITFDWLKEEWANEIDFVVWTGDNARHDIDRRKPRTPKEIFDSNRMIVDRMLDTFGRDMPIVPSIGNNDIYPHNVLAAGPNRITEEFLLIWKHFIPSEAGHVFERGAYFSVEVIPDRLAVISLNTLFWYDSNTLVDGCRDHSKDPGALEMDWLEVQLDNFRQRGMQVWLTGHVPPHMSHYYDNCYLRYGDLALRYQDTIVGHLFGHMNIDHFFFIDVDELEATSELTSIFSNTTSRDLPLLNGAHLPKPGPGKYTTMGRSSAQTLEEELRKDFGEMPGPNILKLKDYAVMNVAPSVIPTYYPGIRIFSYNISDEGDSLDEGHYYQEADELLDDEGGEDELEELEPPSDNDFFGSPDERENEDVEILRRSGRHRHDKPKGDCSLPENEDKPHCTFKRKPRHYSKRSPSRTNRALSPLGYTQFYLPSMMNQKKKPEWEIEYTTYKVKKLVPSSPENTTQPLPVPLHLLPEYDPRIFSKPENKTEEKEVAKKRAKFYKAVKAVTPYRMKDLTIGSWVKLARMLVLEKKRWKKFAELMVVSTETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTR3</accession>
    <name>A0ABR3BTR3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614233.1">
        <property type="nucleotide sequence ID" value="XM_066757849.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990207"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="226" mass="25300" checksum="BB1D77926B846683" modified="2025-10-08" version="1">MSDTHDSPQIADHAPHTVHSNPAPTPSSHNIPPLSSQPSQEQDNVPLHQPTQHAHIGEDEAAALAMEADMDASVMIDPSLMGDEEGFDPTTLANLAALSRIINDEDEDMQVDEMAPEPEPEDEPLETGSPREPLTREQVQEFMNQLAQRDKSKDQEDKDKDHEGSKDNEQGDAGDKDDKEGDQEEEEVRSEKGEDEYEEQGKVKGKRKRNRTVLSCTECHRRKRMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTU0</accession>
    <name>A0ABR3BTU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase SDR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614561.1">
        <property type="nucleotide sequence ID" value="XM_066757092.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989404"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009385">
        <property type="entry name" value="PRK12744.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27060" checksum="E4A38E5C8A4FB8C5" modified="2025-10-08" version="1">MSSTNLRGQAAVITGGGKNLGALIAKTLAKQGVNIVIHYNSPSSKSETEATLKTVESYGVKAAVFQANLTTEASVEKLFSDAAAALGVSKFDIAINTVGKVLKKPIVETTEQEFDDMFLVNSKCAFFFIKHAAKNLNEGGTIISLVTSLLGAFAPGYSTYQGSKAPVEWFTKSAAKELQPKNIRVNCVAPGPMDTPFFYGQETEDAVAFHKSQSLTGRLTDIKDIAPLVEFLCKDKWITGQIIFSNGGYTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU14</accession>
    <name>A0ABR3BU14_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614109.1">
        <property type="nucleotide sequence ID" value="XM_066757725.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990081"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0249922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="78" mass="9188" checksum="83B009736F053A61" modified="2025-10-08" version="1">MKNNYLLSSRANPLSLQYVFLVPTDRPGVRGRGLYTSYSLVIYYKYFSIYIDWVPNSYTSWECLFITPPKLASYCIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU29</accession>
    <name>A0ABR3BU29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614521.1">
        <property type="nucleotide sequence ID" value="XM_066757052.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989364"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045634155" evidence="3">
        <location>
            <begin position="18"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="291" mass="30568" checksum="22C148E72207B3CA" modified="2025-10-08" version="1">MLFSSLITLIIALPVFGSSESRQSRSRIRNSQSLSSTFEQGLEKRGTVYSGRATFYDVGMGACGISNVASDYIVALNSNQYGSGYPGPQCGRSITISYNGVQVAATIEDECPTCPYGGLDLSKGLFDRFADENLGVFYMTWWFNDETNDATTSTSETPTYVAPTSSYVAPTSTYTPPTSSYIPPTSTYTPPTSTYVEPSTSSYASTSIYATPSTDSSSELPSSTLSSTNSLADAVIQTSVPVSKTASTTAAASAAAALEPSVSEVISLGNLVSLNQAVVNLGRILVLGAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUI1</accession>
    <name>A0ABR3BUI1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614786.1">
        <property type="nucleotide sequence ID" value="XM_066757317.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989638"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="216" mass="23429" checksum="9469D9DD1573F963" modified="2025-10-08" version="1">MSAPEATSTRQRTNKAETPTHEQQNPASLSANPSKKVPRNKPHVKPPFVDMSMNKFLTYLVLSLFLLFVFYMWRFTVWAHQVGGYWALMTGHHISPAEAAAKEAASSASASSSVVGSTATVSGHPQNIKAKPSTQDTVHGDDNIQSQIFNLASALGITPAELSSAIRPLVDPSVPNPIEKAKQETRLLQAKMASQQHENENQEGSVLDMLGEALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUK6</accession>
    <name>A0ABR3BUK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102809</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614813.1">
        <property type="nucleotide sequence ID" value="XM_066757344.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989665"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="5"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="672"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="809"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="897"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="948"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="405"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="708"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="768"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="861"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="908"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="970"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="986"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1003"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="128"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1063" mass="115121" checksum="39F9881CB2919573" modified="2025-10-08" version="1">MDSNAIQIAVRVRPWHPEKELPFVQRPSTQPFFQGDGNFGQIPPKPAAGSLREVVDVIDHRMLDFDKPLEEPGKRGTFVMGRRYKNRKYVFDQVFGMGAEQEEVFAKTAKPLLPGVLDGYNATVFAYGATGCGKTHTISGTEEQPGIIIRTMRELFDLVEDTKDKYDTYFEMSMVEIYNETIRDLLGDDYPNCPYGGLKLLENEKERVTIDKVTLKRPTSVEEVMSLVMLGNDRRSTSFTERNSVSSRSHLVLQINVGRNERGTDIDVANSIVRQCSTSATLSIIDLAGSEKASVNRGQRMKEGANINKSLLALSGCISALCQRPVRGVRVHVPYRDSKLTRLLKFSLGGNCRTVMINCISPSSKDIEETNNTLLWADKAKKVSTKVSRNTAGVELRTAQWLQKIVTLEETIKTLRSQLDNSHNAKSGLQQKRLEKARAESQEELGKVQTELDALLPIIVEGSEMEALWSASVLQVEALEARLQDITVEVKEGRTEEDAKKEKDHLRSLIVQQDDAFRFNHEIQAGIQNKSLKYITLTNLLKKAEERMFGEGIEEALYQHQLKVAEHKAHTARSVAAARERGLRDYISQQAEALAKAASAFSRFSNQLRSEISAVQFLQSGDDLASVKSRLLALGNQVDQSTAILFGKNHPLPAAPPQHLLPVSLAAPSPRRVSIGRHAPSPMRHSQNASPKSVLRKNLFSGMSVPEKTTEVKPRQIRWPDETGEGKIDDRSIAPDCPLFSSPGSGGEDSVLEEETGHVSMIPPSLRPASSATPCSATSQAPSPSNASTNEEIPAWKQMRIARGLASQTGGNVAGNLSCDSKSPTSGSSRVGSMSSSVKPSRPGPLSEMSIQTSASPNPPSSSTSSLLKPTASSAAKANGSSAFANIKIAMPASATAGAMLPPPVPLHRRDSMIGPDRHGRPKQRLSMIPSHAETLFPGVGKGLPSGGLSNLSGGARTISNDSKKRMSVQAGSVGNSYSPPVRAPSMSSRPSLSNLRGAASAGDTSVLTSRGLSTRPSMSRLNAGDVSALGPLPRSSLSTRYSMNKLNSGVTTGDAGGRPAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUP7</accession>
    <name>A0ABR3BUP7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614841.1">
        <property type="nucleotide sequence ID" value="XM_066757372.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989693"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="267" mass="30151" checksum="9E9C745D3BB274EB" modified="2025-10-08" version="1">MGKFSEFLASSKEELQKAVPPPPSYGESSTSVRPPTPPPPFPPSFGCIHLARSDRIRLIGLPPVVYDDVEQAILRVWVAGLQGKFPMYQSLEWKLSGYPWTGQGAEAVQARRLLCHVLHALSKHGWYLHMSVDLSKKQFDKDTLFLHSVYPQERYFFSISFNEGDKVRIIDPPSEHVKQAFMTAVRTWPRGIQSEKEKEPGCYQFKLKGLPWYTSDGVQVIHARLLGCTILTAMDSVGFELKGSVDMSTGTSEYANDMDTWFFANKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUV1</accession>
    <name>A0ABR3BUV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="14">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I308_102395</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="14">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="14"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614409.1">
        <property type="nucleotide sequence ID" value="XM_066756940.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989252"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="96"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="286"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="514"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL0250222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="543" mass="60141" checksum="CBCDDCB8ABC00A56" modified="2025-10-08" version="1">MSTKPHSTTNKRKRTSNAHDEAPAKRVPEASSSKVTLDNSQTASTTSTDAVLGARSAPGTAYERVPFSTLNLSPPTTAAIERMGFETMTEVQARTIPPLLAGKDVLGAARTGSGKTMAFLVPSVELLSTLRFKPVNGTGVIIVSPTRELALQIFGVAKELMQGHSQTFGVLMGGANRKAEADKLVKGVNLIVATPGRLLDHLQNTKGFVFKNLKALVIDEADRILEIGFEEEMKQIIKLLPSENRQSMLFSATQTTKVTDLARISLRPGPLYINVDETKEASTADMLEQGYVVCESDQRFMLLFTFLKKNLKKKVIVFFSSCNSVKYHAELLNYIDVPVLDLHGKQKQQKRTNTFFEFINAPTGILLCTDVAARGLDIPKVDWIIQFDPPDDPRDYIHRVGRTARAGKSGKSLLFLLPSELGFLRFLKVAKVPLNEYQFPQKKVADVQKQLESLISKNHYLNTSARDGYRSYLQAYASYSLKKIFDVNKLDLAKVGKAFGFSVPPKVNISVGSIKAKKSKDEDESSDDDGQPRKAYYRNRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWA2</accession>
    <name>A0ABR3BWA2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615370.1">
        <property type="nucleotide sequence ID" value="XM_066756593.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988900"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="30677" checksum="A3CA3C786F423566" modified="2025-10-08" version="1">MKIEGKSFVITGGLGSIGGATAKIIAEKGGYPIIFDILSPKDGEKRIKELPNSERYVYQQTDIADRAKMEQAIQEALEKVPNGSLAGGVHCAAINPGMPWGPKMADKLDDFEKVMKVNAYGTFCVDAVVADAINSQYPPLDPFHDRVEEERGCIVNISSIVAFDTPARCLTYGPSKTTVLGITNAAADFLAPTGIRVNSIAPALVYSAILNNGGRGDYFKEEMNAHSMFPRRMTNASEIGDAIIFLIENSMMNAFHLKVDAGWRNVSSWACGRDPRKLSGLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWD7</accession>
    <name>A0ABR3BWD7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactinol synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615420.1">
        <property type="nucleotide sequence ID" value="XM_066756643.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988950"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41377" checksum="E5D09439F4F3F976" modified="2025-10-08" version="1">MAISPPSTPGVQESRAWVTLVTNPSYVAGLLTLHRTLSSLSSYPLLVMTTPSLPGTHSSLLRSLGFTLITVSHLSPSSSQHPGFDPQFSRLNEAWTKLQVFGLVEYDKVILIDSDMIFLKDMDKLFDLELPGRDWIGASPACVCNPFKLEHYPKDWIPASCSYSTQQSPTPLLSLPIPSPCAPRTSHLLNSGLVILHPSSTVLASLIDFLNTSPTIGHAKFADQDVIAEAFKGRWRPLPWWCNALKTLRGAHKGLWRDEEVGIIHYILDKPWSARPASLPPHQPPSPTLPPSPASLDGSDDGRAPYLEKPQIRRRSLPHGLLDAVRNTPPQRSLTNYDEVHAWWWIVYEDLLDDLKARGVDWESVDKWVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWK9</accession>
    <name>A0ABR3BWK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615490.1">
        <property type="nucleotide sequence ID" value="XM_066756713.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989020"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046263070" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="177"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="486" mass="51957" checksum="DA1F64E4376EB0EF" modified="2025-10-08" version="1">MLFSNVVFPLFTISFAAPAVSAMHLNPAHAKRAALANRDLGSFKLVRSEDALIAGRNKGKRLVRKKKRSTCQAKVNVTSSSIDSGTSPIETASATFSTMAYASTSEPASNLSTYTSSESESATETASAIATNAIGNIENWAGGSASASSSSVETTFTSSASPAAQTAASSSGWSLVEEWSGNTFFDNWNFWDYSDPTHGTVDYVSASDAWNEGLVSINAAGHAIMSVDTTEVVSGSRKSVRIHGNKVWTGGMVIMDAYHMPTGCGTWPAWWQNGPNWPEGGEIDILEGVNDFTQNQVSLHTGVGCTIPTDTNGHQLATLTTGSYDSYDCSSANTSNQGCGARDETNDNSYGSAFNSINGGVYAMRWDKAGIAVWFFQRSDIPSDITNNSPDPSTWGTPVANFSSVSCNPYEFFYDHFNIFDTTLCGDWAGADGVWNYAGYAGQDQSCAAITGYSTCSDYVLNKGSAFTEAYWEVAYVKYFNSTTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWL7</accession>
    <name>A0ABR3BWL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_102170</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615498.1">
        <property type="nucleotide sequence ID" value="XM_066756721.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989028"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0252778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="497" mass="53966" checksum="5ABD7E1152C735F5" modified="2025-10-08" version="1">MLPTLRLFRMASTRTYAEAVSLLNTCQSNAATIEAFRKSGGRLTEYAIAEMHDYLRRIGYKPEDLNALNVVHITGTKGKGSTSAFTERILRAHMPGKKIGLYTSPHLCAVRERIRINGEPISEIEFAKYFFEVWDRLEADSKPLTPQTPKFPVYFRLLTLLAFHAFLSSGVSATVLEVGIGGLYDSTNIVPKPVVTGITSLGLDHTAVLGNTIEEIAWNKAGIYKKGVPALSVVQDKGGDVLKEVAEKNGAPFEVVPTIPPTPLGLPGSHQLINASLAVSLSSHFLSSQGYNFAPAIPPAVIPPSFLQPLASARWPGRCQLVRKGKITWLLDGAHTVESLRSCGEWAWDAEKEDRVPQVLIFNCSGGRAAESLLGELLESGARTRGISRDEIARKFDSVIFCTNVTYIDGHFKSDLDAKAIDPNDLSQLATQNALRDAWLRLNPSFAADRVNAVASIQHAIRIVDSLGEKTVLVAGSLHLVGGVMEVAGLQDALSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWP4</accession>
    <name>A0ABR3BWP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adhesin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615291.1">
        <property type="nucleotide sequence ID" value="XM_066756514.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988821"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="670" mass="73885" checksum="E34E3CC11CBEE254" modified="2025-10-08" version="1">MILPEDTKAPISSDDEFDDDFTSLPPSPFSPSRLLPAQDANQLYPFEYSALITSAVTQPLFLSEEDDIELGPAPPYTPDDPLHSRPQRKNDGKGYLRGKVGRRFMLGIVWGMGLWVGMMGMGALGWRLLGPGPHPGRRGPKQPQPGFPGTSPAEDSWLRESIECVSFSSVGWGPFSPSDMVEPLVPLEHSKEEQRSLNATFYLPLDSDVFVEMWKGPAALGSIMFSSYEAHSEEEWKGIEDESSIVAHNRQGRKPGPGEYVRVIVETIVDVETGTQDEIDSQNSAGWEMLAASSVCLNRRGPTINVTLPEEDLEDTTGDSGQNEEHRPFIQDHPAKNGYGVEIATSNPVESLYPDSRRSPLQFRVHIALPSLTTQEHKHDITPSSSFVRSLDVRAGNSAIYFDELEDVHIGELSLFSEFGEVNLKKLRLENLNVRTTGKVVGEVAVSNDMTIETPIGEIHLNISLATSPRFNLMDCLPSKSVHQSGPGGLQFLTPRPPAPMCTLPPVHVNIRAGGDPVIVHYDDWEIPSRELRMDVFSLIGDVQIFPHPLFQGPFRLMTSKGPISVDLNNALIPDPEGLGRWRNITLEERDRLGSHSYLGNVAWQAEYVSNDLEQSAHEMTSVSLPADGQGTVNQKMLPSPPEDHGPRLGPKTEWGINIRTSVGSINVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWX9</accession>
    <name>A0ABR3BWX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dynamin GTPase</fullName>
            <ecNumber evidence="1">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102194</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615522.1">
        <property type="nucleotide sequence ID" value="XM_066756745.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989052"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="9">
        <location>
            <begin position="233"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="8">
        <location>
            <begin position="823"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="933" mass="103527" checksum="AA4CE46D8811AAF8" modified="2025-10-08" version="1">MSSAKTILRRLPTARPYILNRTRPSVHARLYLTPPARHVHVRAISFSSIPRAMARAFRVPLYGAAIGAGGVGYANYKLESVRNATSEILSNVTDKLSSAYNSASQLGSSIQDTLSDTASGVQDTADALKQGTKDWWDAFTSQFSRNQEKSSGSGAEGKQKWRPGEGPGEPNNGGPTGEEALIGLVGAAAVAKAEEERSDPFSSGGGDEHHLLQLTKKLIEIRSVLLSVDQSDALKLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGNNMVTRRPIELTLINTPANAASSSTTPAEYGVFPNMPGMGKITSFATIQKTLTDLNLSVPPELAVSDDPIHLQIHSPHVPDLTLIDLPGYIQISSMNQPEELKDKISSLCDKYIREPNIILAVCAADVDLANSPALRASRRVDPLGTRTIGVVTKMDLIPPEQGAAIIRGDRYPLHLGYVGVVCKAPPVKGVIRSFMGDRESPNVTGAVLKREEQFFGGENAKYFKHDHLMFGTDTLRRRLMDVLETSMASSLHGITNAVQLELEEASYQFKVQYNDRRITSESYMAETIDALKARFKEYTAQFTKPAVRAKLKDMLDDKLMYILEQLYWNDPRASELGKLAEDRKLSAEDLEPYWNYKLETASSLLTKSGVGRDSTTLVADGLRQLIDSIATGEPFTFHPSVTDRITEFSLAILRERMGITADQVENCIKPYKYEVEVDDREWAVGRNRAEEKFAEEIKRCDAKLTEIKGRVGGSRKLGGLIRHVGDLERWEDERKRRRLSGVDGEADDSAVPVLDAYQYSPAQIVDGRHALLLSNRLAILKLRQQALKSRRCRSGPEQAIFCPEAFLAVVADKLAYTSTMFINIELLGQFFYQFPREIDSRILYDLDRDEIAKFARENPKIKQHLDLQERKDKLEQVMRSLQGLVNLQKDTKPPSTKREGLFTKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX30</accession>
    <name>A0ABR3BX30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614598.1">
        <property type="nucleotide sequence ID" value="XM_066757129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989441"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="8">
        <location>
            <begin position="127"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="245" mass="27672" checksum="D664F73678132FFB" modified="2025-10-08" version="1">MPKSKRSKLTTLSKTPIRSTKASKQALVNEIRENVDKYDYCWMFSVGDMRNDGLKEVRAQWRDTGRFFFGKGKVMAKALGDTPETEYQDGLSQIAKRLKGQIGIFFTSHPVDETVEWFESWHKPEYARMGAKSTMDITLPAGPLLTPFTDPPSGDPFPHSMEPQLRALGLTTSLVRGIPSLNNPHVLCVKGEKLSSEKCRILKLLAIQMADFRIHLGSRWSKESGFVEGKELDEGSEKEDEMEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX76</accession>
    <name>A0ABR3BX76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102633</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614643.1">
        <property type="nucleotide sequence ID" value="XM_066757174.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989489"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="18"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="341"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="380" mass="42484" checksum="9FC3ED5382CC857D" modified="2025-10-08" version="1">MPPSLHLDHLLSSTDHTDFSARRQLSDVSAAIAKARRIVTVSGAGISCSSGIPDFRSEGGLYSLVKNKYPDTFFTGKDLFSAGTFANRESTSLFYTFIAELFHCCASAQPTRTHHFIRKLEQKGKLLRNYTQNIDGFERRMGLESGGRGNGLKKKGTRNVELHGDLGRVRCVLCFSDFEASDEWVEMFREGEAPDCPACWKRCESRINRSARATSVGTLRPSIVLYDEPHPLGDDIGQLTAYDVSRRPDMLLIMGTSLKVHGLKRLVKDFAKAVHGGKKRGLVVFVNATPPSKEWEGIIDVHIEGETDKWVEKVEEEWRRVRPGDWEVQTTLDSEVVPVVQTAKPKDKAKAPKNKALAKRDTNRPSPPPRLKVSLRPRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZB4</accession>
    <name>A0ABR3BZB4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615948.1">
        <property type="nucleotide sequence ID" value="XM_066755662.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987961"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1241"/>
            <end position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1277" mass="140705" checksum="DDC1069FB142F320" modified="2025-10-08" version="1">MAVINKPPYLHSASALIKTLRAPVDTPEQVGLTKVQVALKAWSATDFNIPRKAEILRDWVLEAWNRAKPNDKNNVLIQPDYHSLLLQLGRFEEPGAPPPLQILSSFFSTLSKSDDPKSKLVLSTAPASFNVLFNPQDLTYKTENWVDVWANMLKLLSGDSLQGYEVQLASLLDLVVAGIQRSQASSTNPKKTSEPLASLFATIESSLDQAARAEGCLLALPRLFNSLVSVYHQNSFTLFTQASSSRIPHDVFVASKERDAVRGTLEKTVSFLDSVEAKHSRIASERSSSWVVKSWIWQSRVAVWQALAEWGGYMEREEPWGRMVDATARRAEAVLSTYATDGSLEANVFLGKVLETLATLEQLDHDQASIGPDVVRWCLAAPSDKHIVATRILSSLLRFHQLTHTIPAFFILLLTSLRGLFDSSLPEDITQSLYELIIKGPLVTRNFREELVAALRTANPGRRRSAHWNLVFGELARGLQDLVASEPEPEAKSKKRKAPHDPSSSSAALVGIRSRLLSHCLEAALETAYDGEPSNDSLSNFLPFLEDWSNTPVEVPKLHKKGNSNVGVVWPVTVITAGRLRVIRCAEKMLRRQLGKDEDLSEVLGWNASPDELKLELVRFMYHRGALRLQTHKALPDSFSSELDAVLSLLESALKVQDVPSSALWQVVVEQGLVITDFSGSASQMSRLASICVKALALYPFTRNLFAAAELWELRRLRGALQETVLRISASDPASLIPFLLACPPGHLGRKARNSAIEALYAQKNLVQSLEWLSRMAVESENLGALTQNVDVLVKLAKIAGKQIGGHSPALILWKKAIGHLCSSPSQYEDLLIKILEHYLKLIKKVKKGKSESAETDIQAVAVFCREAMAHNFESFPDAVRKEMVDLSDKAVSYVQPLLDEQSVDLARLGVIIEVYNTVMRFSNWVGAPAKRSGLGMKLAATVLMECQRCKNERDAERASKAVLEVVGEEPNSTEEKLAVVIMFYSTFPKSELDETVQNVFSGKIEDAIKTCIKLVSAKSSRQNAILSVLKVVATSCSKPDLVRQALQEGLLASSGDDNSVRFARAIVEDKVTMLQTDDVLLILSTLFHALFLPLSSSTFNCVLEIITIINRRRPELIFATLPQLVQLICYIFPRFQVPRTIMLLGRPSPSTSLTEEDAKSFSRLLVSLAQCKPAKSKTHEASPLAKHIPAILVAYIRACADPSLGFTTAVRKDFEPGLHALCDLTTAGGRANARGREGEGLGTPFGLGEGPGGDGEKELWAELWLGWSKGRYMGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZK7</accession>
    <name>A0ABR3BZK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nitrogen permease regulator 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615419.1">
        <property type="nucleotide sequence ID" value="XM_066756642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988949"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="69322" checksum="ECA743E40498F3F5" modified="2025-10-08" version="1">MGATGESFLPQVVGLFYATFDPSLGPVVQYQVPENLISDSTTEEARTPSNSRSRSRSRASRFISPSPSPSPSPAKTLINFGPISEYVIPKKSLHGRLVTLLTTGTGCDEDEQVGYRVMGFPNVMTAAEGTYTRNEYMWNLCFVFHSSSSLEAFEPIVRKCARILRSAERDSAYLSKPSPEHTALPAVLEQLFEDLNSYSETSIPLDGFNSLELKLFPFYPNPPDCDDWHVPVALIDLNAHKDDNWDITAARVCQFIDGVNHVKKIAELAEADEALTRETLRHMLYYQVVMMIDIFQYSNMYTLKPIISRLSADETIISECACYVTRSGFPLPDWPTLLQLYSRFQPGVTVHRWIEAHEVLSMGIDPRRFVSFGIIKGFLRRVHRWPKLVERREPLIHVPEHRKRVGFDESARGNSSGFYKDRDRSQSQTHLYQHGNQHTDGFHPNDSAVSLSRGNIPRESSFTLRSVGSNASLGVSPSSIPTRTPPSLHGRSPRRHAFAPSTTGTSSMHTAFPRSHVSAAESHPSTSSRRAIGPSTVGTTTTGGLAPGGSGFNYRYGLSTRQAAAIKQAEELEEELIGFLDGSHHADEIQVRFGWSWGQLEKILGLDEVIGGMGRKGVTVIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZQ5</accession>
    <name>A0ABR3BZQ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Distal membrane-arm assembly complex protein 1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616089.1">
        <property type="nucleotide sequence ID" value="XM_066755803.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988104"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028036">
        <property type="entry name" value="DMAC1-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15055">
        <property type="entry name" value="DMAC1_Dmo2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Distal membrane-arm assembly complex protein 1-like" evidence="2">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="80" mass="8237" checksum="5E26664260A16976" modified="2025-10-08" version="1">MSSTASNPIDKRAFPGKDCLTCRLTGAAAFTGIGAYALVQANQQGAFKRIRPQGAPVVAGKITALIGTVFIGLGIGRLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZU6</accession>
    <name>A0ABR3BZU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin interacting protein 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615872.1">
        <property type="nucleotide sequence ID" value="XM_066755586.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987884"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="12"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1270"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="971"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1186"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1217"/>
            <end position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1295" mass="142330" checksum="42370E07BCA71BC4" modified="2025-10-08" version="1">MGAVFPFVGFLSRPRPMSRLPAGRGRETKFSFYNGPRRHGPNVDAPPARTLPVRPSSPTFHQRRPSRGRYSGSMTRAAPQHKRSIPPNRSATPTGSQPIAEVPKSRPWASTQASASVQSSLPSQTQETSKASEATSTNPVNPPVRKRQRTSEMAEEKGEEDQDINVAAAYSSFLQALDNWLEMVLKQKQARQQFEFHSKFEKAVPINPRFLAIIDAVKEANSKVDEAQAAVMKASQEIASLTLKSVAPKLLVEVQRIQEIREVPVEGSSGTSVDAAKVTVEKKKEEQRASELEQLKNKISDLEGNKNAVQDLVGRLKLLEAWREQEEGQKTAGSAISPNHSDAAIPSERPWLNVVSNAHTSNSVNTPPTTAVIEAQSASGPQLSDAAEPNAAPAPLSSRTPTKMLVGFSRKAKLNAFINEIQRRIAAVEAAQAETRECFEDISNVLAMEREDKLIRQRLREKRKKDDALVEDNYIDRNQDESQPLVKEGPNIVFQGVSGQSGESTSALPADMVSAKLTVALNPSQARASPVPSQPIPSVPVESQPQPLPHSQPVLRNPNPSQEVSTSHVQTVPVAQFPTLAHQPSIPAQAAFTEPTSCSTTTCQSPSSALLVPFAASSATGPTSVSTTTSTRALTVESPNVPSALSPYPILPIPQPPQSAAKTRDTELNTTSVSSSTPTASPTHIASAERIVPMFNDLVKFYTSLRVDLTVTQKSTAELVQGFAQITQEIQSLNSRTSPNYEHILQTITANIKEHGTKIEDLKNVHSKFGRELHELTGIFEDFRLRFNNNFSVAESFSSSFRTSIGNHDVEIAGLKDAIHQVSTLCRGQHAPQIVELQKEHQHSQQLILSVRNHAFQLSTAIRDLADKVQELSSEIPTTIKAIVHDLATVTASCDALHKQLTSHEEMTRKMDNLSDMVEQAKQQWKRRVNLREGESNGLRSSVEEMSQVLVDHSSEGSKTLPGTLVNEDRFRRLENLVSRLQENLKRRDEERDQLITELSARDAKFTLLQQELIEMKMKVEADRKVGEEVNRETIMTCVKDAKEELVDKTKEDIKQAVDTAIENYASRAKKLTNDGALWDDKLIMSIQLAKQEMRQEVPKILSREINLLKELRKEGKKKAAYLTMATGSNLQAGQYDDQNTLKQNPMPDQFIADDGSSVERTLPELNSGATHNSPKPTTPPLPASDLNTQSARPPSQRRLSSMSPTDSRPPTPQYPPDTQESAIGALQGQSTTMQRHGSQSTQVESVIAIEGLRPRTPSISPPVELSSATITQDTTAADHPKSTAITLLKTREKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZV2</accession>
    <name>A0ABR3BZV2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616131.1">
        <property type="nucleotide sequence ID" value="XM_066755845.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988146"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0253910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="505" mass="54533" checksum="1EDB7325F88BF4A6" modified="2025-10-08" version="1">MNVFADEATEERGENARLSSFVGAMALGDLVKSTLGPKGMNKILQSASNSNITVTNDGATILKSIHLDNPAAKILVNISKVQDDEVGDGTTSVCVLASELLREAEKLVTVQKIHPQTVAEGYRIASRAALGALEASAVDNKDDNAKFREDLFNIARTTLSSKVLAQDKDYFANLAVDAVLRLKGSTDLEHIQVIKKVGGKLTDSYLDEGFILDKTIATNSPKRIENAKILIANTSMDTDKIKIFGARVRVDGTGKLAELERAEKEKMKAKVQAIASHGITCFVNRQLIYNYPESLLAEAGIMSIEHADFEGVERLALVTGGDIASTFDAPEKVKIGRCDVIEEIMIGEDKLIKFSGVAAAERSLHDALSVLSQTVKESRVTLGGGCAEMLMSCKVEEAARTVKGKKALAVEGFARALRQMPTILADNGGYDSSDLVTKLRAAHYEGHSDAGLDMDKGEIASMRQLGITESFKLKKQVVVSASEAAEMILRVDNILRSAPRRREAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C019</accession>
    <name>A0ABR3C019_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Replication factor A3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616203.1">
        <property type="nucleotide sequence ID" value="XM_066755917.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988219"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11680" checksum="60B4625C0609DB28" modified="2025-10-08" version="1">MSRLGPEPRINSKHLSEHRGEIVRLIAKVATLSGDTATLETSDGGTVGIHLPRDMHIADQYVEIIGTVKEDLTIRAHTHIGLGNNLDLRAVNSVIEFSHSPIGQGVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C034</accession>
    <name>A0ABR3C034_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Carbamoyl-phosphate synthase, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">I308_101117</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">IND107</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615962.1">
        <property type="nucleotide sequence ID" value="XM_066755676.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987975"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="681"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="1216"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="22">
        <location>
            <begin position="1472"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAL0253741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="2333" mass="254750" checksum="3B9284831B603C84" modified="2025-10-08" version="1">MSIPTPPAFQGVVPPSDIPASQQASSLAPAAHSAVAPEADSPNMERTPSSTPMPRPAGSLYPPATLKGIDYQGMPDEPKWDDSMGEPDAVLELADGLALAGHSFGAKKSVAGECVFQTGMVGYPESLTDPSYSSQILILTYPLIGNYGVPERPDVETSHVPTSEDAHNVPPASSLLDSLPLEFESSHIHVAGLVVANYHPSFSHHLASSSLGKWLQEQGIPAIWGVDTRMLTKRLREGGVLLGRMLNKRQGVVDGERSRDGQPGVLGGVQRLINGLSTSTSLARSQSIDPFNVNWREDYETVPYYDPNHENLVAKVSTKAPVVYTASTGSDKKMHPQTGRQMRVVAIDVGMKWNQIRCFRERGIEVKVVPWNYDINNESEPYDGLFVSNGPGDPSMVKETISNLSRALETSKVPIFGICLGHQLLALASGAKTRKMKYGNRGMNLPCTCATSGRCYITSQNHGYEVDVTTLKNGWEPLFTNANDGSNEGIWCGKNGKPFFSVQFHPESAPGPRDTEFLFDVFIQSIVDTAREGRLISIDVPGGELAANIAAKPREQVKKVLVLGSGGLSIGQAGEFDYSGSQAIKALKQEGIYTILVNPNIATIQTSKGLADKVYFLPVTPEFVLKIIKHEKPDGIYCTFGGQTALNVGIKLKDEFSKLGVKVLGTPIETIITTEDREMFARAMEEIGEKCAESATAVNLTEAIEAAQRIGFPVIVRAAYALGGLGSGFAKDVEQLTELCGKAFATSPQVLVEKSMKGWKEIEYEVVRDCRNNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDADYNMLRTTAVNVIRHLGVVGECNIQYALNPYSKEYCIIEVNARLSRSSALASKATGYPLAFIAAKLGLNIPLNEIRNSVTKLTSACFEPSLDYCVVKIPRWDLKKFNRVSTALSSSMKSVGEVMAIGRTFEETIQKAIRCIDDQLPGFGDHAKIEDLDYEIANPTDKRLFAIAAALKKGYSVEKLNEMSCIDPWFLTRLQRLVKTEQVISQYNASNVPSALVRNAKQLGFADRQIAKMLSSNELAVRRLRIEAGITPFVKQIDTVAAEFPAFTNYLYTTYNASEHDVDFEDNGVMVLGSGVYRIGSSVEFDWCAVRAIRTLRENGMKTVMINYNPETVSTDYDEADKLYFENISLETVLDIYDTEHSSGVVLSMGGQTPNNIALALHRQNVKIYGTSPEMIDTAENRYKFSRMLDKIGVDQPLWKELTSFTEAKAFCDKVGYPVLVRPSYVLSGAAMNVVFSQDDLNNYLTQATDVSRDHPVVISKYIEEAKEIEMDAVARDGKMVMHYISEHVENAGVHSGDATLVLPPQDLDAETVRKIEIATQKIGHALNVTGPYNIQFIAKNNEIKVIECNLRAARSFPFVSKVTGVDAIEIATKVMLGLPVTPYPDVKMPANYVGVKVPQFSFSRLSGADPVLGVEMASTGEVACFGKDRYDAYLKALISTGIVPPKKNILLSIGSFKEKLEMLPSVHKLHRMGYNLFATAGTADFIQEHGIPVKYLEQLGSENDLNPQKKEYSLSQHLANNLIDLYINLPSKNRFRRPASYISQGYKSRRMAVDFAIPLITNVKNAKLFVEAIIRKPTFDISSVDYQTSHETFTFPGLVSVQAFVPGAAEENSTDFGEATEAAIEGGFTIMQMVPQGINSAVEDEISLQRAQANASGAAHCDYSFSVAATADNASRLQDAIAAGAKALYIPFNNFYGANNKVSSVSQHFAAWPADRPIITDARATDLASILLLASLNNRSIHITSVSTKDDLLLIALAKEKGLAVTCDVSIYALFYSQVDFPEAAKVLPTKEDQDALWDNLASIDVFSVGVLPYELGRALNKPVSARSGVAESLPLLLTAVTEGKLTLEDISLRLSENPRAIFGLPEQSQTYVEIEVNRQSSFTAENAERTWSPLDGKAIAGNIHRVVANNHSIFLDGQTFSMPFGRDVSASGPRPAKKARGSFALQKRPSVTGLMSPISEKTSSAGGKLMSLASVAPIQEVSPVRGLVSVQTHPTFSRRHILSVKQFDREDLHALFNVASEMRTAVERSGSVDTLRGRVLCTLFYEPSTRTSTSFEAAMKRCGGEVVQVNASTSSVQKGESLADTIRTVGCYADAIALRHPSVGSAKAAAKSSPVPILNAGDGIGEHPTQSLLDVFCIREELGSVNGITVTLIGDLKNGRTVHSLVKLLSLYDVTLNFVSPRSLAMPESVKLEVSRAGIRFTESFTLTDEIVSKSDVLYVTRVQKERFENVAEYEAVKDIFVINNDVLEKAKESAIVMHPLPRVNEIDPEVDFDSKRAAYFRQMRYGLFVRMALLTLVMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C061</accession>
    <name>A0ABR3C061_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615992.1">
        <property type="nucleotide sequence ID" value="XM_066755706.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988005"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="55"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="321" mass="36070" checksum="F55C2279E7DE323B" modified="2025-10-08" version="1">MTTDISNINGISGPAVYNNEVAESSKMAAEIDPVFHAVNLARGIFNVGYLNQEWSDIQLTFFASGLKSHRLILARSPYLAHLMSATTPGTTIHLSFADSNVTEESVHIALQHLYKPSLNLVYPQNARAVLATAFLFGGMPELIHHAYLVIRDSLDAKNVVDLVYWLEVSSDPSAVYDGQTSVQNHREDSVKAWLSDPYPRYGEWTIRLRHDAVNYLLHTLPERVIQENKFNVTDDPLSITYAHLPYELFKALVESPELPIASHQDRFTFVKKVLVRRKKIAPSGGPQMEENVVLAFRGGEGMEVHVTRRPKKGRTFFKVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0H9</accession>
    <name>A0ABR3C0H9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription elongation factor SPT6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Chromatin elongation factor SPT6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_101499</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPT6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616341.1">
        <property type="nucleotide sequence ID" value="XM_066756055.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988357"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1129"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1458"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0254120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1506" mass="171449" checksum="088FEECF84FE5195" modified="2025-10-08" version="1">MSDRSGSASEGEGDEIRPYGEDRDSSEESEDDDPEEAKRIAEGFIVDEDEEDAEGEDDEEDEEARRRRRKEEKRRRKKERRMRRGREEAELSEDELELIEENRGLREGRPLKRLRRRSGSEGSENDRAVPTLQDMFRDDEDRMEDDDDDLMDFIEEDEEDEANQGETEEQRRERRRAEKLKRREQARSRPELTGVDRSSWDEIFAVFGDGQDYDWALEGEDGIDVDEEEEAAKKDLRLEDVFDPAEIKARRLQDEDKAVANADRPERHQIVNSTLSDNPVFATDTLYPPPDFAAKWIAPKVSFRTQYLFCNQHPEGSYPIPTVDNPQPYPVYRRPDLEMEFEKAVSTALNMMFVQHLEVPYLWHYKRDVFSLLENQGQSSVLFLERDELWQVYVLGQRYRAIHERNEQTRQQWEKIKARKGDIEDEYFTKGLLGKACVTSIEAAGEGAEWLAYHYASDIKAIKEEEAFDEISKKLPEKAEHEDIRRGKIMKLVEAFGIDANKVASSFQDVNGQPAPVMNPDKMPLELADEFTGAAYSSPEQALSAASFVLIQELSKDPAIRQQARDFMDACGLVTVNTTDRGMSVIDQYHLYYNFKFLTNKPVLAFRDSPQFIHMLKAEEEGLISIAFDIPENMLATFTDALIRCCRSNDYGEIASAWNDVRVEACNTLVKKHLMPMASKWIKEHLRTQAEEYIAERCREELELRVNVRPYASSGMEHGETPSVLAITNGKGDIRDAVMAVMLDDEGNVRTQTKFDNLRDEEDKTIFIELLEKRKPKVIVIGGFSVQTARLKDAALAAIRQHAIDLLGQNPPVSDAYPDHEGFQYAMAEYDERLKVHLIPLIFVNDATARLYMASEEAEKEHPNLPLNGRYALGLARYAQNPLNAYCKLGRHIASVTFMEHHQKLIPQEKLLYHLERGLVNSVCFMGIEINSCVADPYQRAMLPYIAGLGPRKADAVIYGIQKHGALINRMAFTDLGLFGPTIFENTAGFLTIESDLKDMMLEAENPQEQPDPLDMTRIHPENYEFAQKMCQDALDLDVEDVADRHKSEVVQTLMLDDKRGKKLGELNLDDFAFNLQRQGEGNKRHTLGEIVSELIRYRSDRRPTFYVPTDWEIVTMVTGETERTVGRGLKVTATVRKALSARVFCQLESGLDAVLERDYVADEDQAPVTSCDEVFKPRQAIKGVVIMPEPARFQVRISTRPSDLRQGVDFVQPFKDEEYNNKDRRDAAEAATAAKKQRRAGKAQRIVNHPNWHVLNSGQAEQFLASQHRGDCVIRPSSKGPDRIAVTWKVDEDVYQHIDVQEIDKPNEYSLGRILMVGGQYRYSDLDDLIINHVKATARKFDEIQMHEKYKPEHELDAFLKNYVQAHPGRSIYGFSVDSDRPGYLKLCFLSKPTKDGGVIQTWPVRVLPGAYKLGNAIVPGVTELSNAFKMQYSEKLAEQGHQGKTPGIYLGKTPMHLGGRTPALGSRTPAMGSRTPALGSRTPAIGSRTPALGSRTPAQGGPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0L1</accession>
    <name>A0ABR3C0L1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PFA4</name>
        <name evidence="15" type="ORF">I308_101528</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616369.1">
        <property type="nucleotide sequence ID" value="XM_066756083.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988386"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="92"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="280"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0254148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="740" mass="82909" checksum="A5BD4CF0338DDD02" modified="2025-10-08" version="1">MATRNWSPVWVGGTVVLISFIAFSSQIFVIWPWYGREISLDLLKLLVPLNLAAFMIFWNYRLCVITSPGSVPEGWRPNIGAMEGMEVKKGTHTPRYCKTCEHYKPPRAHHCRQCKTCWLKLDHHCPWIGNCVGFYNQGHFVRFLLWVDIGTTFHLIIMVRRVLYMAEYYHQEPTLADVLFLVFNFAACVPVWLCVGMFSIYHVYLACGNSTTIEGWEKDKVATLIRRGKIKEVKYPYNLSIYKNIKSVLGPNPLLWLWPQKMQGDGLSFPVNSAAGDHRAQYFWPPQDPSRLPNPPPIPANASPFIYGNNGFNPNLRPTNALRARRSSTPRIEDENVHSHDQDRQYSSGEERDYGSNSASSSPEPYLSDYDHYGDGPMYPGERIMAPGPRVRRGSEGWEVAPGGGWNAYAATMDEEVGWDDEAGYDEAPEEGLASIPEDDDFTFISGSSGLSDTPSLTPLATPHDSPSRLSLASGSDLEMVASDGIKFHTCSELLQAASSVFAAMMRPSKSGSPLTIYFTDSYVEASPTITHFLHLLSSQSNSSLPTPTVQSFTHYETLILFLKKFQCDRALLEKLSKMMRGWLEEGCISASRIFKAGCMMGDEALCKFAVQAGNEWTWVGDSRSGSSPYPPGNKRQNFNFSSSEFDLHEDGVFGAPALDITAMPYAFFRSLPDTHKFALLRATRNVVGAMVMLDQCDWDKVAEEFEKILSRVKRCESIAIFSKIKADAIPLRGPLLKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0T2</accession>
    <name>A0ABR3C0T2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616464.1">
        <property type="nucleotide sequence ID" value="XM_066756178.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988482"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0254243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="81" mass="8438" checksum="7B8A7227CEC5E2C0" modified="2025-10-08" version="1">MGACHSQHAHRNSRPRHPPPNGPIRHRPLVLAPIPPPPSQRHATSAGAGGRQKKSSPSSPSSLGKFGRSKNGSTGGGRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0T6</accession>
    <name>A0ABR3C0T6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101612</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616452.1">
        <property type="nucleotide sequence ID" value="XM_066756166.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988470"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="270"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0254231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="553" mass="59426" checksum="5E3A1EAE5C5C6E1B" modified="2025-10-08" version="1">MSLADALLADLDGLSDDEARSPSPGREASSSSMPPPNLPNHGKRSASAMEVDDGEGGEDEDEGDDMKLEDGTSAVGFVPEGGVRPADELDKEEVEKTDMKGVEDVKKVAKLAGSHKLQDILADIAKYTESPTDMSSSAGPLEENPEYHLVVTANNMSVEVDNEILIVHKFIRDHYAPRFPELEQLIVEPWTYIAAVNAIGQSEDLTKVTFPNTLPAATVLSITLTATTSRGRPLKPAEWETVQRAIVVAQNLRSAREQIFSYVESRMASVAPNLSAIVGTGIAAKLLGLAGGLQAFSRQPSCNVMLFGAMKKTLATSHLSAASQQRHTGFIFQSPIVQSAQPEDRRRAQRAVSAKCALAARIDAGKGSRDGSYGRKCLADLQKRIEKMAEPPPNKMIKALPIPQETNRKKRGGKRARKAKEAYAQTELRKLQNRMEFGKAEEEIGVDDETVGLGMIGSAGRVRGEMADARSKAKLSRANKLRTQLLGRSVTSNDAASGMATSLSFTPVQGLEIVTPSLSAAQRVQAANDRWFAGGTFTHVKKGGSILPGQGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1E5</accession>
    <name>A0ABR3C1E5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenoprotein W</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616445.1">
        <property type="nucleotide sequence ID" value="XM_066756159.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988463"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0254224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23562" checksum="FF07B868FEA1C03C" modified="2025-10-08" version="1">MSEICKDCDQSRTQPASSETMSQNVISPESSLPGADVVSSPTSSYVSPQNQAQIQTALQPPLEVRAGQAKVEGIENKNESTGTSTPLTPGTTAQTGQDFKSPDLREVKPSVIIEFCDRCRWAPRATWIQTELFLTFPNPILRSITLMPLNAPETGGRFRVWVDVGKGKGDELVWDRKTEGGFPELKVLKQRIRNLVQPDMGLGHSDVHGKNSEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3K4</accession>
    <name>A0ABR3C3K4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Enhancer of mRNA-decapping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EDC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616501.1">
        <property type="nucleotide sequence ID" value="XM_066754600.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986878"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.100">
        <property type="entry name" value="conserved c-terminal region of ge- 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044938">
        <property type="entry name" value="EDC4_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="727"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1032"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="734"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="785"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1231" mass="130972" checksum="26DC364B0DB48CB5" modified="2025-10-08" version="1">MDHQTRLFQMLNAATSPPPSKSAVTASSPREPQPTLPPPTLQSVSLNDLFKGIQLQASSPSVSANGSAAGTRLEKSNASVAGPTVGLSHVGQHTPGTRSASQASVGSVPVSSPPPASGPGQDQRSKLLGMLSFGGSGAGTPVNVSTSGVPTPLPGHVQPESQAGAPFGGIKSPVIDHSNPPQPTIAPVQEPAIVSPPVVESTAARTPEPSQPQDQAEQPRPKSAVPNFSFVSPFDAFDEPTPVTASPAKEEKNPEPEVVKQEEKMQVPAPAPKEVKSKKSKIKSPVPPKAPELPVVAQEAGVKEGSVANNTHQGQQGSGPKTTQSHITIDLSKPNLDSLVPTPDLLYIQPTTLLKVDVAYKKGRKVGLTRQFVAYTMSKGKIRLIDSRSGARLMLQTTTSTPGPIIDIAVCPVYVAALAADRSLWIWRVPAGWREDNPPVDLTLVSHTADGAIGKAFKVGWVKKNGADWVIVAGDEGVAMFDPTREGRGVKKAEETFAGKTIFRTMGSVVDFCVNNTQSAMGILSSNSTFSLYSTQSLNRVWQRSIPSSSPHSPPSSAHFVESNVLIGRDQNTRFDLVQITVSLAVLSSIHFIAPPGLDASSHYAHAMYDPFSGLLFVTPFARSSLYAFRYALKDTEPVRDAGSPDGPQVVAFDRMAEFPLTQQGSSGTGVVTIGMIAHLGRDPGPGREEGDLEWFYGTAEGFASAGMGKQAMGLVKGDVLASTITSPVADASAEPKKEKEMQPERKEKKRSAQSTPTSKTFPLPQNLPVPQPVPSLGSRTDSTAGSVVEDADGAAAAAASTGTNSRKLKKEKRKEERALARAQAAAEAEAKIEAAWGAETLAAVPEIKSEREVAIGEEAIKQMEDRLSTQFQNLLTASISPLSAQLNTIASPSFSNNIAAQVERSLRPHIMSSISSELQNTLKGLMPQLINEMKNEVQKEVKSCLDKVPKDLEKGLGPVVSRTVAGVVQTSVEKMVQQAIHSHLLPTLTQSTSSLTDTLLTELKSEMLQIRKELTPIPPPVAPEAKRGVGEDELLNKLQEVSQQMEALQTAVKDIQGKNFNGINHAQSAPNLPITQGSPPSIQNARLPTPAQLEDTFLAALTAQTVPATLQLVDDHLGLTDYCLPVTGKSPLSQAVLLTLLHRTSIAIAEIPALHPLFPHLVTWIRRTVNLLDPSDPNIKEYIVRLHPVVQTHLSNVIASVQTSRNPHLQAQFLPVLKEIGDVLSAKVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3U6</accession>
    <name>A0ABR3C3U6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100089</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616569.1">
        <property type="nucleotide sequence ID" value="XM_066754668.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986947"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="674" mass="75138" checksum="08D43E3992A12AB3" modified="2025-10-08" version="1">MSRSSSSAPKAIGKARTKQGSLLAAVQLVPDGDKPYRRSRTGCLTCRKRKKKCPEQYEDNSCLRCKAGGWKCIREEDVSGGSSRSQMADTSPKTRGSPAIQQQQLQTHQRQLQKHQVAETGPSQIHQLQDALHSPSDGASSERSSAAAAQVYPNMDEKSLSMAVHGASAGHSNLVGDYRSNFLPDNIWMDQPLDAILSATAPTFDISFYGSFGDPNAPDPFHFTPALEFDTADSGSGSGHRDSTFFDNLPSELALEHISSEEELLYDFYNRYVVPAWSLTYPSRTRKAVIARYYEVTNAHRVTQLCRLAVAAVYITFLRRRASHQASWVGHSGLPMNDVPEKYLSLKVDAEEMVRKATLLVRSPRDLNITMEAHFWALSDLHMAVGSFCDSSRAYAIMDLAEGLLALTYGLHPEVDFLSLNGYIPFYLRAFAMIDLNRSICQRRHTFFAFLETPQMGGVGFLNDGSHDQWFGLPAGLAVCLASLSNLIAEVRDPSCSLSPSDISSASKRIEANFKAYQSPFAVHDVSLDRHPIAWAAELSVETEIWRHLGLLLLWRLVDQQSVLITPMRDTIHLVINLLKSLQYVSAPRVERENNVIDFWSLNYTTPAFLIGTLLVDRDDRAFCKRFLGKLGGEKNLEDMIVALETTWAATDRSGQVADWFEECTRLDLAVTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C455</accession>
    <name>A0ABR3C455_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-1,2-xylosyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616694.1">
        <property type="nucleotide sequence ID" value="XM_066754793.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987079"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="385"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="693" mass="78633" checksum="17805C12650840A9" modified="2025-10-08" version="1">MPLNLPFSSALKLPLPRRFIILILSASILILFLHTFAPSTLPPVLTPNLQHHEPDASYFSPSKWLPPILNPNAPTRPLEFDEEGQCLFLSPFDALSAAEKARAQVLSLNEISPGIVRAEAPPAEGTDADPDFDDEFSELSNATRKMPTGLTHPILGLLRDGEAKWNSMLARQSQTLEEAVNVYIERWGRKPPKGFDEWWHFAKANNVLLPDEYDAIMNSLLPFYALPIETLKERLTEAEKIPETFTLIVHDGKVELQWNDDYSRDTWWASRPRADSQINLMEPFIKHIGTFRATFTIHDQPSVLLDYERQKELLTAARQGKISTHRNEIDRAEQNWKKACAPDSPLNKGEEELEASDSFISSHLAAMDICQHPSYLENHGMLLEEKNADTHPKPHTKLYPILVPSKTALNGDIPVTPIGKDGRRDDVGHDPEWSRKSGKLYWRGLATGLQHNKKAGAKWRQSHRERLHFLANDKSDAYTEVLSPVGSSGEAELAQMPLKELGQYYMDVKLAGGNWQCDWGDGTCEEMEKEIDFAAKDSSERSNDFKYVFDTDGNAWSSRFPRLMASNNVVIKSTVFPEWNTNSLPEWYAYVPSKMDYSDLFSIMTFFRGTPSGRGAHDEVARRIALNGQCWVERTWRREDLQAYMFRLYLEYARLTSPDRDNGKMDYVPTPKKISNVAHGVPVAADVEPPVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C472</accession>
    <name>A0ABR3C472_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">V-type proton ATPase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100235</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616708.1">
        <property type="nucleotide sequence ID" value="XM_066754807.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987093"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="71" mass="8124" checksum="3DA9D24CE4F56938" modified="2025-10-08" version="1">MSFFHVVFVAFVIAAIGAAGWFITPKGKNQTLLRTSLLLTLACCYLMWAITYLCQLHPLITPRRSDLRMEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4G7</accession>
    <name>A0ABR3C4G7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616641.1">
        <property type="nucleotide sequence ID" value="XM_066754740.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987025"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="616" mass="68180" checksum="159D8CCE554F7288" modified="2025-10-08" version="1">MNPSPNTKNQSSLSFHDLSPLVKEDNGENEQCGLQSHWSDCGSERAGRKKDARFSGSLKRMFTKSGKNGEVGRSRCSSADFLVRQLKGRSSPVKDIESPIRRGRPATEYFPNFLKISSYTPVRPHTRLTDSHGAGCGPRSIERSMSKHKKTPLRTSNIISLHWKSGDRARIPSTARSSESRSPSPMIKRRGSLVQRLQSLDNLPDSRYPGPKAKGSYGTPTPERPRPVRPPSQSSDVLPRLGSQHSSPQKRIRETGKLEEDVFSAPASQQESSRRKKSATQPTCGSNHHEQPFREPSRSFSIELLSEANVSYQTNYSVSPLAQHHRQGSLDRAEALVMLERMKSTGKLKVANPDPPKVSNSSTATHQLSPSPRTKPVTTYSLYGGLAPDSDDSLTVNKTPQRSPDKYFTKERQDNSPVKSYATPSRNQEYTSFQRVQSSRKGTNTLTPTRPERSPQRPVVGSVATGKSQSHEQEQDALFEPFVDTLAYLACPQSPSHSLARTSTGNMSVFHDSHINSPSPKSNHEKEEEEELLLDSDASSVDSGDYRASWGSERRLSMGNVSVTDMYLESFYGDDMNDQVGTGDKSPGRRTVEDDGPLVPKSLRKTKKIGDRSANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4P7</accession>
    <name>A0ABR3C4P7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Short-chain dehydrogenase/reductase SDR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616876.1">
        <property type="nucleotide sequence ID" value="XM_066754975.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987262"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF7">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE (AFU_ORTHOLOGUE AFUA_2G00830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35722" checksum="3F5CF4818A6EDC18" modified="2025-10-08" version="1">MASSEVLHPKAVAVITGAASGIGLAAALRYAKEGASIVLVDIDPAALDPAVEKVKSVEGVGTVFGIRVDVGNVKEVAGLRDRVLEEFGEVHILMANAGTSTQAPSFSLSTPLEELQSDWNKVLNTNFFGVLNTAQAFAPFMAKQENSSVIIITGSKQGITCPPGNAGYNVSKAAVKVYAEQLSHELRSDPDSRCTAHLFIPGWVFTGLTGANKMGATKPPGAWTPEQTVDYMVDKVFQEGDFYVICPDNETPTSLDKARIQWSMEDVLQNRPALSRWHPSYKARFEDFIQSKQGLAARSRSRGRPAQRDGSQVPSVVSIPSETDLLAFRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4Z0</accession>
    <name>A0ABR3C4Z0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear pore complex protein Nup160</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616836.1">
        <property type="nucleotide sequence ID" value="XM_066754935.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987222"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056536">
        <property type="entry name" value="TPR_NUP160_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056535">
        <property type="entry name" value="TPR_NUP160_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23354">
        <property type="entry name" value="TPR_NUP160_120_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23347">
        <property type="entry name" value="TPR_Nup160_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="5">
        <location>
            <begin position="62"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 middle TPR" evidence="7">
        <location>
            <begin position="958"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 C-terminal TPR" evidence="6">
        <location>
            <begin position="1230"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="825"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1480" mass="163431" checksum="AB767A151E066218" modified="2025-10-08" version="1">MATYVPHHLVHAHLPAPPSIPASIPELHVPVNESVPIPDGAYEEPLHPDHAVSVVHDTANNILARNISNGYVLELRPFGPTIAKLRQNVETGSEVIRIFFPEPLRPLSPGLIQISNEEDRLFIIVISQANVIYRLNFPLGTFRRGTDDRFIFTTQGEEWLEDWEVPEHLIGACGGVGATTVFNRETIVLGGGDGGIVIVTRSGNYSPDSGHWEATHYRASSKFRLPSLFSRSANSAEQIVSFSEFVKEGHVRIIYTLSRDRKLRAWNAETGTCLRTVDVRSSSQAVILRGSDNSAFNSEDGSVSMIRVVHHPFASSRYSHLVVAFFSTQQSASSAGSFAVFRASTNSYGVSDLSFAGEKLCSLASAGSELRGLEVLPPVKLHGVDNGWRLWTVWDRDGSSACEVVTIDDVFQFTTYIETNHPPLLSDWQVVVAPPNVEQFDAAYFDNLLPPSPPNPAEPEDNGDIPATFIQHLFHPGRFSTSTLQTALEDYTYQLSRKNNRAQVSGPISSLSKRFGAIVGSQLEIEVSPDTGAPVVDVYRKQLKLEWLGIWATVRDLDRQSRWPVSTSTIGQSLFVLTREGISVPVPEEAAGVVDRLGRSEIEANQFLNLPEGALRRVYPSLGGSDARVAVLSVTMSGEYIAGLLKSQEAQSGESDVPSMGSLLDVLIRNINDTLAAGLQGPPELVAGSLWDDFLDPVLTEDERMNIRRILSETSSVDRGLVQCVEILEDCSFAFNSSEPNSEPSTSFSGLGNALLSSTLSQIIESRYALARNVLFTSLFYLADSFDPLDDSEKSEELIEILTRVIVAYHRYRVLKWVAGQTGEETGERKQATKAQKAGRSKRKLGDDGQTDVLGGLKVKEMEDNERDTDEFTTAYSLLHCLVARLLAPEVPGSDMTLSVLLQAAMNVLDQVHLLSSNQIDIAAQSPDVVLGNKIFIDGHPLLAGAYSDLYPLSSGIAYLKGRAYLEAGVLDGAVQYLEKAAVGCKDGSLASILPFASGPNGLSSYYSKVCDIFQSHGISKAAANFGQLALDTASGDAPPSRDLWTKVFMANLELSLYEEAYAVLTSLPFVDMKRDFLGHLISEMCEKNEVGRLNSLGFIGFQTDVEELLRFKARNSDPLRKPNYYKVLYSWHVTRGDYRSAGEVMYLQGRRFVEGSSSKYPIFELSAMQARSYLAAINALSLIEKRNAWISVPGAPSKSLKGVKRRKMSSYVPEEEFTKGKSPVDIITLEDIEMEYTVVLSRLRISSHIPDMYDHGVAISPQEIVGLFVQRGMYDIAQSAASSLKVDMTDLFQSLASRCVELSRLQEHAGDISAAAFLQTSPVTSRLQGPPATLALHYLRVALQRHDSSRTNWRYREAVADTLFQLNKDKRQGWNMPSWLVQWEMERNAEGWIGRALRWGWVSEALDWSIENLRQVTPPELLPKEKSNAVCLPYNLFDRVLAAAGKGDEIEEALVQQKAKILRKEVSRRLEALESLDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4Z9</accession>
    <name>A0ABR3C4Z9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616978.1">
        <property type="nucleotide sequence ID" value="XM_066755077.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987366"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF10">
        <property type="entry name" value="DUF1115 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G14750)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1078" mass="121375" checksum="9274072E04B85989" modified="2025-10-08" version="1">MMISTDIQLTPPAIRQSIYNKAIIDLRHTVGIEYVAWMEDIAARVFDQFTPLDTTIFPETFGPRDEDPLIHFGEWLNTYSQNNHHVHDHFETPKQSVEADKRMKDRLRQDVINRHKEARVMGPAERIIISAVEHPFPSYLHPQDVLMTVRTMRETPSFEGGKVGPKEYAHLGDEGDLHILIKLKNSLPKASKIEEADALDLHLNFAKKDLKKAADMVKTMKCKLQEPLRGTDGISSLCAIWDKWEKDSKAKLQQLPEPLSPKLFPRCLTKEPGHNQLNTFKDIEQLVTPTAANGLKLPIPREVMIQSSSRESVMEGRNDFVEEVFRLKNLDDFDGVPFAPLTPNSVVKYSRIPTSVSQRYNHLPISPPPTAERKSKMPWDQDPRLGKSIVKIKSNVRLEIPVMPARISSSYMNPDSVNRLFTAVENPSPPARTRSFESGSAAATLSCSFKDDEDVNTPSEAQVFCDLLVNGGTQARVNRSGNYGRAEEEAMAYAMEEQLDTSKTSHMPAYGDPSNDLPKTFCELLEGSKNQGLEADKQMFIKYPGLNTALASELSWIPFSTVSDAALIEEGAKASPMPNNPPQSITVPSTDLLAQTTPHPSEMILRKMVERSPKSMTPARPRWMTIQDMDKLKGSVGDVRSDELFQAPSPAPTATRRKKRKEVPQKDPGEVDELFEEGPDLPQKPTAANNNPEKAMWINLRKKTKVKDVLQSNPRKTSLDDITEIITSRALTRARALTKNIQETSLTMPDDASNMKNDLSTIKGFLYLQKLDHLIIEEQEPTYKLPPNQSLSPIFEDEEPMDWRLDPILTNPEWFIQIRALQPQSFETPMPLMATVSLFQNRPLIRMLESRGLYLLDSFPSLQGADLVISPTTALVFRPLSSLPDIHVGLLEELKLAATYYQRVILVFETISYAASERYTKTSNNFNPLATAVVHALGSLSRGKKAAWGARNIIGELHIVFAYKGAGEIANSVSKILQEDEERLRENMGEESYLQYQGREWIGHEPIVEHENTMVEMFGINTFSARYALATYGGAERLAYEMTEDERMDQLGPIWGQTTTARFNDTLREILAAEVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5D8</accession>
    <name>A0ABR3C5D8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617114.1">
        <property type="nucleotide sequence ID" value="XM_066755213.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987504"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="170" mass="19682" checksum="63B5E735C904F341" modified="2025-10-08" version="1">MSQPPADTPQDDWQVAYVWAFITTFNLRHRIPRLESQQDLEYSLRQPVAIRPDDLLESTLICFLSNLRPALRNLNAENIQSYLSNYISDQLATTSEWTVWDRPWPINEENRGPCCNDDPDRAELGRLRHQGEPAADRAQRNPLKKMEEKGGVSGLAVSSNSFRTYPRYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5D9</accession>
    <name>A0ABR3C5D9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Complex III subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100647</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617115.1">
        <property type="nucleotide sequence ID" value="XM_066755214.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987505"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="149" mass="17552" checksum="718B0675C4C1A734" modified="2025-10-08" version="1">MPSIAKMVFGNGPLGPSFAPLIRQYPGVQKYWARWSNLYKHAAGYRQKGYLLDDLVIEESKTVQKALSRLPERVAYDRVWRHRQGIMMSMHHSDLPKDKWTPAEKDEQYLTPYINQVLAEEQERADWDHSVVERIKQRKAGRKNPFERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5K5</accession>
    <name>A0ABR3C5K5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_100713</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617179.1">
        <property type="nucleotide sequence ID" value="XM_066755278.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987571"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="11">
        <location>
            <begin position="4672"/>
            <end position="4888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4019"/>
            <end position="4547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4021"/>
            <end position="4030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4064"/>
            <end position="4092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4102"/>
            <end position="4112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4127"/>
            <end position="4145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4161"/>
            <end position="4180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4194"/>
            <end position="4220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4236"/>
            <end position="4283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4344"/>
            <end position="4356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="4375"/>
            <end position="4388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="4402"/>
            <end position="4413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4419"/>
            <end position="4428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4471"/>
            <end position="4485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4507"/>
            <end position="4534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0255902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="4900" mass="544812" checksum="34DC1976D00481A0" modified="2025-10-08" version="1">[encoded data, 4900 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5L1</accession>
    <name>A0ABR3C5L1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617182.1">
        <property type="nucleotide sequence ID" value="XM_066755281.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987574"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="377"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="808" mass="83762" checksum="BD0E20BB86A2139C" modified="2025-10-08" version="1">MAGPAKRTRHHDENSASPADSASSTTVASAAPTAADSSTPTATPPTTRTNPASRRPATRSTQSNSTLFTVATRQTNSALNATGSMPAPSGSVMRGVGRAGVSGGSGRAVPAGPSTRSGGSGMLLRTQSAPVIASPVQIKTAAGAGGGEAAPPKGGHDGLGLGERRFGKGKENIPPKKDEDQQPEPARKRMRVTSRGSYSGQGGRKRSGSVNSVRSETTSSSRHSSLAPSSFSSSSISGWGGPCFPSPSPSQASSFDASHFDRLSVSDKAGHAAAHTSSKNRPVTRSIAMLPTPPPSTPPEEVAAAADVLGLGFVLETLEASDTETEKAPANPYKQLKSFLRLSTSFAAGASVDETIIGRQEEKSAIRAYISTSEAESDVGMYVSGPPGTGKTALVTAIGRELAEDGWKVVEIGCMGMKATDMWKEIGGMLSCGKTEKDIKEYMTQEENKVLIVLDEIDSLMPPAPATAPPAVSHLFAKLFALPLTSSTTKLIAISNTLDLTIRASLVLPNSMHPQVLPFKAYGQTEMSAIVNSRINAAKVEGVKVDTTAITLLGKKVEAQNGDLRMCLGVLGSAISLAEAEWTKKISQAANDPEPKPVAMTKIAVSHILKALTSYTTQLRAAAGTSSSAGSSSATGKKVKSVQLQGKMVLVAMLVYLSRTRAGMNGCPAMGNNSGASTSSSTPTASSGTDIPAPALYATYSHLLSHTTSPFPPAPESDYRDLLSNLETLGLISLTSGSGSSRGGASASASKVGFCVREEDVKDGLWSAEGKSKGTADEEVKKIWEREEAKVKRVREKKTALVKADNDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6Q6</accession>
    <name>A0ABR3C6Q6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617102.1">
        <property type="nucleotide sequence ID" value="XM_066755201.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987492"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046655815" evidence="1">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="94" mass="10315" checksum="2BEBB766853C51D3" modified="2025-10-08" version="1">MSFSLPLSSFLPPPTFALSILFHLSVLLLPDSRPPSASYDRSQQANLYSGDRVHVGDCASPITHLAEGHQPLIASWCDSLTIVREVVRNVDEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C8B7</accession>
    <name>A0ABR3C8B7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616991.1">
        <property type="nucleotide sequence ID" value="XM_066755090.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987379"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469:SF1">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="7">
        <location>
            <begin position="97"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="728"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="741"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="826" mass="90687" checksum="A941F60D28250241" modified="2025-10-08" version="1">MMVPAGFLMFSHTVSKVFRQRVYHIMRIPIVLTAAALFGSTLISAHTLTSTPPPNLHVVIRADTNEPAPGNGTQTWSQGDDWIPFNIVIDPAYGIAGAVLILSGIPVAVLGSKNRWSSLAVASGLAFFLFTLVMILRFGVEPNLAPPSPHPPSATLRGLYLLACLISSFIGAGLGIFFFNFTKYAISAAGGFTFGWFLLALRQGGLITSVVGRWALLGGLTVVAFIASLPKQTNDLMILVSTAWIGATAFVLGVDCYTRAGLKEFYVYNLGFHDLFPKLDGAKYPLTQMMIIELGILGAVVLIGAAIQFRVIGMLQKRLNRLRDEEEARIEEEEISKAAERFKNVGAELVEWEKKHGGNPVSESGLDGTEKSGSAGEASFPSEPYAISFKGNRSSVLLPQLEFKASQEPEILNKRASSSLSLLGHDTSPQMRRSSSLSLPRIASEFGEGSENLNSYTPTNSMFLGIEELKPEEPFVGVGRDSSDLESKLKLLEEIKKARESVQGSLELLRSGTPSGTQSVAGPSRAVIPAELGERQRRHSSVSTKLLDVAKAQTVPGASNRPPFQSHMTETPPQHSEWDTYLAERKIISPVASPSPNSAFLSVDPQCTTIPVSVVKGIGNRRERTMSMLETKVSDFGPAQQEQRHGTFAGRSSVAYVPDIERRESVAHHDYLESGIPSRPLAVNRPRMSYSGPTKVVSASDLHPASATPYRSSAAKIMSIEELAERHRQRLSKMQQPVTSKLKESEQIEEARKEWEKQRAREKDEMRRRETERGRENEDNQGKTREVVRRTDQWRRSIVVDPELQAGGERKRSGEKAKKQGRTLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHL9</accession>
    <name>A0ABR3BHL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_106753</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610712.1">
        <property type="nucleotide sequence ID" value="XM_066761172.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993606"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="37"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="125"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0240204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="169" mass="17909" checksum="07990573545954FC" modified="2025-10-08" version="1">MFTSRLAPALRALPRQASALRIARRGYAEAAATDGKLQLSLVLPHESLYSSSGVIQVNIPAATGDMGVLANHVPSVEALRPGVIEVIEENGQQGKKWFVSAGFATVHGNNSLTINAVEAYPLDKFSLENIKSGLADANRVLGSNAPESEKAEARIEVDVYEGLQAALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI95</accession>
    <name>A0ABR3BI95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610871.1">
        <property type="nucleotide sequence ID" value="XM_066761046.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993478"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF64">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="143"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="484"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="378"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="633"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="838"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="877"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="891"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="916"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0240372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="925" mass="96001" checksum="137DD3D1ABDCC9CF" modified="2025-10-08" version="1">MPRVVAEGQKGFYSYYCKSPLLLSVSYSFFHPSSQPLHSNSPPLFTSQSSQPSQNIHSAFAASSHMSSLFEAAAAFEEAAAHGANPVILERSGKGHTPVVTMTDMSANAPPPPPSDFSSDINRSVTPLMTNLLPSAVGSDGRVNLFVGNLPYRVRWQDLKDLFRKAGTVLRADVSLGPDNRSRGYGTVLMGSREDAARAIDRYNGYTWQTRTLEVRPDRLPPEYEPQSHPIHPNANPRSSLYSFHNFPGPSHTPFSIPGHLTPQSGQAWLAGQISSSRPFSAGGLIPGGMGVPSSSGAVGLTSSTPIPGAQSPPSVFGALPLSVQNTGLSAFHALSQSPLAGSLTSGTGTAMPTGVNAARRDSLTPFGASLTTFDPAAAPLPGNASPNMAVSRPTSSSGSVKPSSPGGSRAPPGTLGPLPPSLFAGIKPAPAGDAIAGAIAGDIPAAQSPNGGAGRLAAAPIPQLEGLANQGMGLGPPSTLHDRVIFVSNLPLSMQWQDLKDMLRPAGTIIRADVATDAHGKPRGFGTALFATEADATRAVLLFNDREIGGFRIRAHLERDTHPEVSQRSARNSVSGESTYLGIQDHLIGVPEGVKDMLQSNGITPIDTSVPSIKPSSTSPIAKLPWSLNTSLQTHTAPGHDRPSSHGKSSPTSHTPLFRHQHHPGPISMPPFHMEHGNTISPLHTRGLPPMTPSMPGFVFNYPETPPVHPHGPHFMSPAAGPFSPGIPVTSPGAFQYNPFLNPAPGAPVNRFPPTPGNHPQAGSAALGTPTTQAFPNGPVGYGQYAGAPGSALQGLSENSQHARQGQDYFANAIPPQNATSITAGNRTLGVGALGGKEKLRSSPLSGGGDQGDSDEETKVSSSLVGEELAKMAESLTVYDESKNGESVRRSSSGLNLSDMGSNAGAVSPGGGRASMDDGKLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIA5</accession>
    <name>A0ABR3BIA5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">allantoinase</fullName>
            <ecNumber evidence="5">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_106580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610829.1">
        <property type="nucleotide sequence ID" value="XM_066761004.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993435"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="57"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0240330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="467" mass="50247" checksum="85ECC2FE534EA4BA" modified="2025-10-08" version="1">MPSQTILAPQAILPDSLRPQPATIVFDTDSGIITSVTLGIHQGKGEADVWKIGEEKVLLPGLIDTHVHLNQPGRTAWEGFRTGTLAAISGGITTLIDMPLNSIPPTTTLSGLATKKASAKEVGVSCDLGFWGGIVPGNEGELRGLWDGGVKGFKCFLIESGVEEFPCVEEQDIIKACDALKGTDALIMFHAELDAPTHTHTHATHPTSTDPSEYSTFLESRPQQWEISALQLVLRIARSYPDLRFHIVHLSASDAVPLLQSALLGDGDTSPLKNLTVETCFHYLCLQDTDIPPNATQFKCCPPIRDESNRLKLIDALLDGTIQYVVSDHSPCVPELKKGDFTSAWGGVSGLGLGLSLLWTELGVGVGGRGRGRVELGQIVEWMGGVQAKQVGLQGKKGVLQKGAVADFVVFDPHATFEVTAETLRFKNKVSPYIGKTLTGVVEKTYLGGKLVWDHGRESNETLGKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BII2</accession>
    <name>A0ABR3BII2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106641</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610889.1">
        <property type="nucleotide sequence ID" value="XM_066761064.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993496"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="730" mass="78937" checksum="2B728EE88B2DCECE" modified="2025-10-08" version="1">MSKLPGVKHKVIGLVSGGKDSCFNLMHCIANGHEIVALATLTPEPGVDELDSHLYQSVGTHLLPLIAQSMSLPLYTKIIRGKAIAQGPEYGSRLRLGAGTGQIGDETEDLLDLLSQVLKAHPEATALSAGAILSTYQRLRIEHVCGRLGLTSLSFLWQSEQSGLLDRMLSSGVEAVIMKVAGVGLGENVVGKQLGQIRPLLAKLESQYGSHPAGEGGEYETLTLSTPLFSHRLKLVKTNTVVTDPEPYTVAYLKVEEAVLEPKEGWVKPTVEELREMLGLEEEDVGMEGLDEEGKERLEELGEREVEAVSEEGRKVGEWSGGDVGGEEVQFLKKKGWFTASVQGVTLPSEDVGQELEKCFNAISSKLQSENLSLPLHSTHITLLLSSMSLFLPANEKYKTYFGTSPPSRATVAVPLSSGRVRVEVIGFDDTSPSSEGAGGRRGPVGNRSALHVQGQSYWAPANIGPYSQAVLVASRLHIAGQIPLIPASLTLPLAPAYPRSPYPHQATLALQHVGRIVQALRSRNATGGGWEGWVEGGVGWWAKSGDGKSGDGVGVVRDAWRIWTRRNGGEDAPIAFVEAKELPKGALVEYQVNLHTGRRDYTMHDEKEEDDDEDEEELGPVYESGRGQGVWWESCYTSGKVQRGSRGLVFVQDMDAFANLLKDVQPETKLGCLLCKAVSIRVYHLAHLDPARLSSVVLSLGGVCTLIPVFSVHDRDGESVRVALEVFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIV1</accession>
    <name>A0ABR3BIV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611009.1">
        <property type="nucleotide sequence ID" value="XM_066760737.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993159"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="176" mass="18998" checksum="B0E8BBA42B26BFA9" modified="2025-10-08" version="1">MNPSRSLLVLTSSFSRLAMRSAQPAFARPAAMPAIRPAMGLERGFASSSRCEATINQIMRGARKSTKRKSSVPLLDGCFQKKAVCAKVYTTKPRKPNSAVRKVARVKLSNGQMTTAYIPGEGHNLQEHSVVLVRGGGAKDLPGVRYKIVRGTMDLNGVAGRISARSKFGVKKPKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ25</accession>
    <name>A0ABR3BJ25_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611187.1">
        <property type="nucleotide sequence ID" value="XM_066760915.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993343"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="151" mass="16844" checksum="EED496DC3BF84FF0" modified="2025-10-08" version="1">MSDIYSYSVEFPKSTLPLSELKGKTLLFVNVASKCGLTPQYKDLQALHEKYGGKGLAIIGFPCNQFKAQEPGTDDEVLQFCQLNYGVTFPIAKKGDVNGENTQPIWKYLKENAEPPVSDIDWNFSKFLVKDGKITWFPARSTKVSDVEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ82</accession>
    <name>A0ABR3BJ82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611241.1">
        <property type="nucleotide sequence ID" value="XM_066760480.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992886"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="139"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0241859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="24777" checksum="AC278903F5F3539B" modified="2025-10-08" version="1">MAKDIPIPRYDFYQTPNELILALYVKGYDKLKDAVKVEFGTDYVIITLPALASSTEEQCITLRPLASTLSPGSTYRVLGTKIELKLLKAGGVMWPSLLAEEGKGVIVPQQQAPGAETSRSATGSGSTSGSKADAVTGDAIGQEKKNKKKNWDKIEDDDEEPDPSDPNAGGDAALQKFFAQIYGNADEDTKRAMIKSFTESGGTTLSTDWSSIGKQTTPVRPPEGVEPRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ84</accession>
    <name>A0ABR3BJ84_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611239.1">
        <property type="nucleotide sequence ID" value="XM_066760478.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992884"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0241857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="69" mass="8061" checksum="20010BD93AAFCC41" modified="2025-10-08" version="1">MFTHVHYHGVILWFNPTSWKLLIEKQYHQCLLKSLFMSSSSLTRANTNVAHSSQCYPHSLLIVKLSQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ95</accession>
    <name>A0ABR3BJ95_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611255.1">
        <property type="nucleotide sequence ID" value="XM_066760494.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992902"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0241873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="415" mass="44598" checksum="AE268108D8CB7698" modified="2025-10-08" version="1">MLGKLSSAISSFTSGSLPPDHHAPEREKANAALAQKLAEADVPVSESDCISCGLPCPAGASTESGAGTVAEAYSGKPYEEYVEEKYGEIEGLPKGFEQDWDTDLAGSAKGGKGRVVVISTGKSDWERDHTDEKDSLAQFLNAAIESAPSIKGDKNEDFLPYISSSLFPPPSQPLSNPITAPPSLYSSSLISQSDDPTDQSVLVFPDWKVVHDVETSKEGADEFYGSVLSGKLGRAGKEGKGKEGVERRRSWVMPYRAVILLCSHKRRDKRCHIAAPLLRSALHTCLTTHDITIDETGSSLVNLEAPPLEEVSGTEEEREREVGRRIKEIEGVDGGDGGEVGIFNINHLGGHRYAGVMLILLPSGAYISYGRVTPQEIPRVVEDTILKGKIVPGLLRNAVGVMRKGGKADKGFLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJA2</accession>
    <name>A0ABR3BJA2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611258.1">
        <property type="nucleotide sequence ID" value="XM_066760497.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992905"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="208"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="247"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="286"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="325"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="364"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="403"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="520"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0241876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="604" mass="66876" checksum="576C7E2F5113ADC0" modified="2025-10-08" version="1">MSDPNSDLYPIHLLMDELKSEDVVLRLSSIRRLSTIALALGPSRTREELIPFIQYQLDDEDEVLLVLAEELGNFVEYVGGKEYAHVILGPLENLTAVEETLVREKAAESISKISVLLSAQDLEQYFLPIVKRLATGEWFTSRTSACALFATPYPNASSSSQEEMRKLFGALCHDDTPMVRRAAAKALGPLIKVVSETSGQHDIIVSELIPMYRKLAGDDQDSVRLLTIPDLIALAAALSDEETKVNLLEPMRASITDKSWRVRYMVANEFVGLAESTGESIIREELVGAFVGLLKDNEAEVRTAASGQVPGFAKLVDKEVILARLLPCVRDLSTDSSQHVRAALAMEISGLAPLLGKDATIEHLLPLFLQLLKDEFSDVRLNLIGKLDMVNEVIGIDRLSQALLPAIMTLAEDKQWRVRQAIIEYIPLLAQQLGVEFFDDKLGSLCMSWLGDTVFSIREAATINLKKLTDVFGVEWAKTTIIPKVLEMGNHQNYLYRMTTIFAITTMAPSLNTAIIQDTVLDAALNLANDAIPNIRFNVAKCLETLASVLAQTPEGQELVHRRVVPALRKLQEDQDADVRYFATKAYERTTGDDVRGAEPMILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJC7</accession>
    <name>A0ABR3BJC7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106744</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610704.1">
        <property type="nucleotide sequence ID" value="XM_066761164.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993597"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="335" mass="36764" checksum="1A393A1807F91E1A" modified="2025-10-08" version="1">MLVRRLYSSASSHPAPSALAHIPAPRPHTRGRIRPRLALPKAKKHATTTTTTTAASATLARPLRPLDTPGKGRKPRYTYSEPASASAQAQAQASSYPSVPEPPSSSIPHTPRLHFTHPVPALNHTNEFRPIYLYPEQFKLHHAFTHPAHPLPLHLGTKIYTSPTLPPQANEAGDDLFAPQSGMKLPSSEGMSALTEHLRVVSSQPVLVDAEMEHQLFGTPEMESSSITALLENKSASLKTRNEHEWQDVLAMMEGKAQGKTVAADGEKENVQVGSKDADLNQVVGELAGVLARLEMDGEDVSMDSVKRKRRKKISKHKHKKRRKATRALRKKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJM1</accession>
    <name>A0ABR3BJM1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610960.1">
        <property type="nucleotide sequence ID" value="XM_066761135.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993568"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06152">
        <property type="entry name" value="YjgF_YER057c_UK114_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="139" mass="15812" checksum="24395DDC25056055" modified="2025-10-08" version="1">MSDLTYYNYKGWGEKAQGSFSYSQAVRVGDTIQCSGQGGWANEGKFEFYKEINAQIDQAFENVQSALTAAGGKGWDQVFRVNSYHVPLNNEALEAMVRNFRKWMPNHQPLWTCVGVTRLGEDDMRVEIEVQAYDPVKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK29</accession>
    <name>A0ABR3BK29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611158.1">
        <property type="nucleotide sequence ID" value="XM_066760886.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993313"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23248" checksum="67BBA871A141A340" modified="2025-10-08" version="1">MSLPYVDDQLPADISAPWPHVDQSPKRLGKHCVQGIINLAPNGPNDGGLMVLESSLPLYAAFFDTHPELEPTEGWPERDFFMFREEDIKWFEERGCKWKKVEASPGDLILWDSRCVHYGAAAKGETPRVATYVCYKPAKDINPEKLGEKKKAFGEYSGTVRFSHDPLEFTFTGTNAYGPATPDEKQQPYEPAVLSERAKKLAGLIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK40</accession>
    <name>A0ABR3BK40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106473</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611173.1">
        <property type="nucleotide sequence ID" value="XM_066760901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993328"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="459" mass="50106" checksum="F792346B4BBD16F9" modified="2025-10-08" version="1">MFPPAPVPFHTLRTHSSPLASLHFSTSTPNSLLYAGDQDGWISVLDLKVRRVIAFWKGHEGGVLGLGEWQGGLISHGRDNVIHFYEPLKRPYIPIPTSSTPDPKSYQPSIKRSLPTNALNFCRFSLVAIPAHTATSVDKKQKEAVMAVPSLIDSELVDIYHIPSLKRLHASINFSSKPPPQTPTNVDLPGTSRTGLVMSLHLFHPPPTSFCADGEERSLGLVIAYEDGRLELLSAPLSSLDTPYDAKMTTSTSTSKGVSMNPWKLRWCGKGHNEAIMASAVDSLGKRGWSVSADHRLVRYEFDLVWQRKCEKDDENVMKPYATKQIGNSSIAVSADDKVVAIGGWDGKIRLFSAATSKPLGTLVSHRETVHALAFAHLAFSPSQPITFADNETSSAETETAATETTTEYPELTVDLDDDDDSDVDDDVDSIPPRERWLASGGKDGKVALWGLMDFSATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKL3</accession>
    <name>A0ABR3BKL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_106130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Golgi apparatus membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TVP23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611338.1">
        <property type="nucleotide sequence ID" value="XM_066760577.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992985"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0241956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="247" mass="26817" checksum="315C4A78B1ECC372" modified="2025-10-08" version="1">MSANAPLLSGTIEPDEEAPSVPQGNIGTSSSPRPSQTPVVLVPGTQTSGIGSVEEGGIRGILKQSSHPMALAFLYLFRSAAIAVYVLCGLFTDNYVLSIVLVVVLLSIDFWNTRNVAGRTLVGLRYWNEVDEEGESAWVFESRDPSRPANPIDAKMFWIALYAYPLGWLALLVVSLLKFNVSFLPIVVLALVFNLSNLLGFTYADRDAQQRWANRVVSGNVFGFDLGGLSGQMVGGLVKNSFGRVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKP4</accession>
    <name>A0ABR3BKP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-nitropropane dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611736.1">
        <property type="nucleotide sequence ID" value="XM_066760432.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992838"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0242354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="37632" checksum="D0333266287DBC3D" modified="2025-10-08" version="1">MSVISTPITKLFGIKHPILLAGMNVAAGPELAAAVSNAGGLGVIGGLGYTPKHLRGVIKELKSSLKSPDLPFGVDLLIPSLEPSARKTNYDYTKGQLNDLIDVIIEEKAKLFVCAVGVPPKEVVEKLHGAGIYVMNMVGHPKHVTKALAQGVDIICAQGGEGGGHTGRTTFSILIPACVDLCKGKKSPLTGQPVHVIAAGGIYDGRGLAASLMYGAQAVWVGTRFVASTEAAAPKKHKELILSADHGDADTTLIYTGRPLRVRQTDYVKSWANRQDEILQLTKQGKIPHDVELQKHPEKSLEGRPWLMGDVSALIHDVKPAKEIIDEMVSTAKQCLEHGYASVSGGQSHSMAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL18</accession>
    <name>A0ABR3BL18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_106081</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611289.1">
        <property type="nucleotide sequence ID" value="XM_066760528.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992936"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="572"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0241907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="991" mass="108452" checksum="C2FE307BC23A3719" modified="2025-10-08" version="1">MSSPNPGRSSSPLHFPTSSVGGTPRASRVQQLSGSGAPAASSSPLHFPTSSPQSSSHAARTPGGFRSEAPSSAAVRRVRDETPLFFPPSGGSTPRRARRGDIHSSFPHSSPSLARRQAQIPADSLSLRASSPGMGTDADGLGTPRVFGSAAPTLSAAAQSQVNAEGDDIDGMVKFIWGTTISLQESMNLFRDFLRGFKPKYRAVYNSEQSKQAEESGGVAPPLMTLYDNLSAERADVPLYETYLNRLRLTGETNLNLDALNLLAYRPTKKLYHQLVNYPQEVIPIMDQVLRDVMIELGHEELEKAQTKFAEGNLSQLELSLITNEIRDVESRVYKVRPFGGEKTVNMRDLNPGDTDKLVTIKGLVIRATPVIPDMTTAFFRCLVCQHTVQADIDRGRISEPERCPRDVCGSTGTMSLIHNRSEFTDKQVIRLQETPDAVPDGQTPHTVSLCVYDELVDLVKPGDRVIITGIFRSIPVRVNPRQRGIKSLYKTYLDVVHVKRTNTARMGFDPSTRAGEGKPPGVGVGGEDDEDELLARQDVDAAMDEDLESPVRSAAAEMEQRIIELSNHPDLYNILASSLAPSIYELEDVKKGILLQLFGGTNKSIARGGGGGGPRYRGDINVLMVGDPGTSKSQILQYVHKIAPRGVYTSGKGSSAVGLTAYVTRDPDSKQLVLESGALVLSDGGVCCIDEFDKMSDATRSVLHEVMEQQTVSIAKAGIITTLNARTSILAAANPINSRYDPTLPIPANIDLPPTLISRFDLLYLVLDKVDEVNDRKLAKHLVGLYLSDVEDQPADNIIPLETLTSYITYARSKIHPVLTEGASEALVQAYVEMRKAGMDSRTQEKRITATTRQLESMIRLGEAHARMRLSDRVEEEDIREAVRLIKSALRESATDPLTGQIDLDLINTGAGQTMRRARADLKREVIRLVVEKARSQGIRWSATIDELNKQSSVPVDHAQFAEIIRELEEESIVKVVGERERRVIKSLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLB5</accession>
    <name>A0ABR3BLB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611959.1">
        <property type="nucleotide sequence ID" value="XM_066760013.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992414"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="797" mass="86007" checksum="F1F8E83504F65312" modified="2025-10-08" version="1">MITPAQPPEPPRRRFGSFGGSRPSAPPQRPSSSASNTSTSPVPTPSPNLMPPPPQRTRSASSTSSNQANNAAAFDITQAADKAHQWLSTWAPRGEGRGREFLISGLNGVASVASTVSSGLNARHERDRDVHRSLSFLGPSASNPISPSTSPEGRFHVSTSPPGPIHTQSTPQFGMSQPDLLVSNGARKVLPPANMARLGHATTTNSTPTISSGPSAVHQQRPASLHLGSTASLPSTSYRSSIHGPSHLGPMSPTHRRTSSSHSNHLPLSFANGSHGMNNKSPSVSRSSSVTGVSAGPYMRNTGMPYKVGFQPQGVRSDRTEDYMGARRAVEANREIEEGRLSRRWAKLVDLHFNPTVSEAAAPTLTRSSSSNFSLSSLGQDRRRSLLSIEGALDAMRPKDIFRGFKAGSGPGGDEGRKRAAEQAIVKWEDDSEVRKCRICSSSFSLSNRKHHCRLCGRIVCSLPPTPPALLAVQIQLFAPADPNATSTQTQAGLPSGTRREKCSLLLVADWKTGRGEEVEEGFVGWMRIEDGDGSGEGQAIQRRLKSQSGDGVDAVRSGDPSMRDIPLPQQPKEVQVKGMRVCRECWAVVSRKQKMQDRQRVTGFARLYQALCTLQTEIEDLAADFEEQLSELASSADIEPTNELFTLHRQLIALFTQYEQLSKRISNLPCQENGSQASVQSAIARSAAVFMTKEMVKLQAIQALQKRSAEAKRKGLVISETTLGQLEKVGVASDAGGDVVEDVAVMLQPLLEQEAQLESYIADATAQRKYEDGKALQSALREIRAEIERITEKASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLC5</accession>
    <name>A0ABR3BLC5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610758.1">
        <property type="nucleotide sequence ID" value="XM_066761218.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993653"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="283" mass="30420" checksum="7A4746246FD32201" modified="2025-10-08" version="1">MFALRMFESPAGNMHWQNYQYNGPLTPEMEITFKTEASRALSSIGSGSLGFSVSTSVTTVNGVTTGLTEFQVGKGTPWTAEETAMLDARFAALAPDGRMVGPNGRPLVMTGSQHPKTIPIEDTPIAAPRSIEAPPLVYAYDYTPFHHSQVSPRYVRSSRSQHSRKSSSYAPSVNAAPAQPAQLYYNPTSPSFYAQPQQAEPTLLHHPTPLAHPTIPRSALSHHSHHPTHANDSSHPHAHFAPSLTEGGTSASRRLSKTPAPGTPAAPASSGSFKSITSRFKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLE2</accession>
    <name>A0ABR3BLE2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611989.1">
        <property type="nucleotide sequence ID" value="XM_066760043.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992444"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="236" mass="25327" checksum="B80771BEF34F26D7" modified="2025-10-08" version="1">MSSSCPSHPASRVVEHPLSPTSLSRTHHQLHPAGERSTTTYDSSGQDVGNIQTRPLETDPMLLLPATTHTSSSLLVSSTDPITTMGQLDRGVVEGYQADQTIETAASSPPLPPSPSSPALPFSKRLFHAFAHKPTLSRTWEKKSFMDDEKKSAPAAMGGGASLERDDHDLDSDGCLASPSAKSKSRSRCRSRPMSLYASPAEIAAFKPLPLMLDDERNVQGHTHMAQMGMLAVTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLG1</accession>
    <name>A0ABR3BLG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105602</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612002.1">
        <property type="nucleotide sequence ID" value="XM_066760056.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992457"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0243635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="384" mass="42317" checksum="CE60A37F0516C82A" modified="2025-10-08" version="1">MSMSSNILVLDGGMGTTLESLGADISSPLWGSEALRTNPDVIRKVHEGYVQAGADLVETATYQLTPQNLCDHLHCSREEAERILCSGVKLVASSITSCSSRNQGHNDKDKGNNGSKVVLSFGPYGSTLQPGQEYGGIYPPPYGPSTSTNAFPPGYNDKEEEAIQALAYHHLDKLEAINQDDAAWREVEWIAFETIPVLHEVRGIRRAMGIMRRKLSALYTRGDNGSLWWDKKFWITSPFPMGQHPQLLPDGSHASIPQVIDALFSGPDPIPNGIGINCANPSYLRSLTSLFTSHLPFEFFGKVEMVIYPDGGQVYDTTNRTWVLAPQSPENSEKWAEVVGGMAKELRGAERDKKRVWKGVVVGGCCKSSFDEIRALRRFVDSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLT3</accession>
    <name>A0ABR3BLT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612122.1">
        <property type="nucleotide sequence ID" value="XM_066759475.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991871"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0243755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="314" mass="32697" checksum="710A1F5C890D86A4" modified="2025-10-08" version="1">MAFGDRGGRGGGRGGPRGGGRGGAGGRGGFGGGRGGGAARGGGGGRGRGAPRGRGAPGGRGGGRGGKAGLGRKGPGAVTLEPHKHEGVYIAKGKEHLLVTRNMTPGESVYGEKRISIATTNADGEEEKVEYRVWNPFRSKLAAGILGGLDNIHIKPGAKVLYLGAASGSSVSHVSDIVGPDGVVYAVEFSHRPGRELIGMAKKRTNVVPIVDDARHPQKYRMLVQMVDVIFADVAQPDQARIIALNAHHFLKNGGAIVISIKANCIDSTAPAAQVFASEVNNMRKEGIKPKEQLTLEPYERDHAMVVGIYQRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLU3</accession>
    <name>A0ABR3BLU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612126.1">
        <property type="nucleotide sequence ID" value="XM_066759479.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991875"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="343" mass="37199" checksum="BD52E2EBAB9E060C" modified="2025-10-08" version="1">MLKPFSSINKLLSEHVIYLHPLFLWLTRHPLSPHPLSLNPSFSLPFRRSSYSVTSLVLGSCVVQSSIRRGSLEKVSELVCWICLVGAHKCGLRLFAGGLHFAGQTKRRRAHCATNAFATSHRPVLQTSSLPSFLTYNNVGVLSLLTFKIQSRTTDTAKHCVSLRLPPRMQPPHKCNGCVALIETDRAMEVTPPTLTRDSDDLNVIAGGAQASMALSSWKPQFSCQIFPPSGSNVLHPLASPLIPPHPPTPSSQPPTPSSYPQAPSSPGQSSLMEDDEAQDDPALLAHSLLSCAICAIADVLMALAMLGLTWATLRGHPSLRTALEAVGLFCLVWCFLISMLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLY1</accession>
    <name>A0ABR3BLY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubulin-specific chaperone D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612170.1">
        <property type="nucleotide sequence ID" value="XM_066759523.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991921"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="3">
        <location>
            <begin position="348"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="3">
        <location>
            <begin position="448"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="2">
        <location>
            <begin position="903"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0243803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1176" mass="129381" checksum="479ADC6524CDB7D3" modified="2025-10-08" version="1">MSSAALVDDWDPTYTHFSHRTEFLDLLQQFVTLDLCKESTEKEDEDEDVVVACLGAILDYYLPMPGLLDPSLDEIVRPLMQLLEKSLHTIVEEDRHTSNPVNPKRLERLGRVLNWVVKVRGWKAVVPHFPSTIPNLPILIKLFSPITSLSASTSPVNPHHHVLSSTTAWELRAVLLLWLALLLTVPFNLSALSDSDDFVSSIPYGIDLPSSELLFPTATSELAQKVTFLTVPLLHRPGREGAYAALVLARLLSREDAVQGLGGFFAWATSEIEDGDRESESHLIASLFNLLALLPSLLKSSHLPLVEGFLGEKLLPHLRGSRTAAESGLIRKLAIKAKGRLWVSKLGKKYSNDDDVDLPEGLEEILDDLMGGLSDKDTIVRYSSAKYLSRISALLPPGFSSQIVLATISLFAGTEEEPVQFTSFGTVIDPGGSSASGGTMGFGGSEVQRGEARWHGVCLALAEMGRRGLIWGEAVEGAVKWVVKALTFDLRRASHSIGANVRDAASYLLWSLSRACPPSALEPYVITVATSLVCVACFDREVGVRRAASAAFQEGVGRTGVYPEGIDVLAKTDFHSVSVRRTAFLTASQAVGVHHVYRTAMIEHLHNITLRHWDCSIRCLGAQALRKLLEQDSKEMLEDALQRELKELVSLDSANVHGALVALKEVAEMFGDDDPRNQTIFDALATIRAPTLVSQQAADILMALCDLLSIILNVSITSYATTQPVLARYIELASKRREVEVHESMARVYRRLSELRNCEKDVAKLINDLRSFRVTQRQSATLALGHIQYPTAPSSMAEKTVVALLGLLKDPTKTEVESRRWAVRSLGDIAVQRRDGSLVVESTTLNMIVRAFIKGLEDYSTDQRGDVGSWVRIASLDSIGRVLASLSPPSPLSSIVEPGIYDEVIGGLVKQGVEKLESVRSASALALARMRECGWWWDTQGAMSVSRKQLDEEGFRYVDQEEWFQSAMPLLETRFRKELVTGLTFTIGSQVVTLSNAALRPFIGYLTVHTSTIVPVLQTLPNLMADNFNSNRIFIPTLQTLHKLLSANVWEKIDAKDHKAGADALMKSLSAATRGLGNIKSIERITAAMRVVIACLAAPSEVRSKATSLISLFLAHRFPRIRAMASEEIYLALSEVNDDMDEELEQVLLEVDWVGSGVEQQAERVVQLLQGPKEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMN8</accession>
    <name>A0ABR3BMN8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612058.1">
        <property type="nucleotide sequence ID" value="XM_066760112.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992516"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045405425" evidence="3">
        <location>
            <begin position="21"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0243691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="545" mass="60426" checksum="17EB849AC89045E2" modified="2025-10-08" version="1">MENSWVTLAALCILAQLSVQRKVLRTVWLLLNVIDTFRALRLVRANGRRIGVNTRRKSMRDALVCWIVYLIGTTLSSLISTLLGWIPLYSPIKSVLGCFFLILRLPCSMMIFKSLVPLVKPYETPVDITFHLFESLSILIFHFGVQLPIVRATTWIKFVGKVDFKRPVEILQRWQRKLLISLRMVSLPEAVRRMSNPKNPPSQIITLPTPPRSVPSSPAARQTSAVRPTTRPRQPRQSKRKPLQPIIISPSPSPPPSPPAPMLVIAPSTPARKMTVEEPAVIRKNGFLDVEGEVEVRRSPRKNKGRRKDDAAANEMEAQRELEKATEIEDGSQRLKSKERVREDDEQPLSHLAKSIAASRTMDGPGVNEPPVKGADVQPSKLRVKKSVSSLKGGAIMSNVSNLRAGKDIQYGGIIAREPKRPHIPPSRLAASLSEQNASSKATMPGFTDKAASLQQSTSIPIAPRRTRKPKTLAITSSTRRLQKSAPDGVAEPEKPLISAAGRARAAKAKAKALMQEEDRKRAGEKRKAAGEGQNELAEKRTRMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMP0</accession>
    <name>A0ABR3BMP0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Transaldolase</fullName>
            <ecNumber evidence="3 7">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 7"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612425.1">
        <property type="nucleotide sequence ID" value="XM_066759778.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992177"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0244058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="323" mass="35329" checksum="80A2E5F6E60ED030" modified="2025-10-08" version="1">MPTSLEALKASGTTVVADTGDFASIDEFKPQDATTNPSLILAATKMPAYAKLIDPAIQYAKSKGGDIEVQSENAMDRLLVEFGTEILKIIPGRVSTEVDAKFSFDTQATINKAHQLIALYKEQGVDKDRVLIKIASTYEGILAAKQLESEGIHCNLTLLFGFGQAVACAEAGVTLISPFVGRILDWYKKANPDTTYTSETDPGVQSVRKIYNYYKQHGYKTIVMGASFRNTGEIAALAGCDFLTISPKLLDELNKSQDNLPKKLDASSTGEPIPKTSYLNDEAKFRWALFDDVMAFDKLHEGIRGFAKDGATLKHMLIEKLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMP3</accession>
    <name>A0ABR3BMP3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4396 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612100.1">
        <property type="nucleotide sequence ID" value="XM_066759453.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991849"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025509">
        <property type="entry name" value="DUF4396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14342">
        <property type="entry name" value="DUF4396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4396" evidence="2">
        <location>
            <begin position="67"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="189" mass="20646" checksum="2ECC072C15DD81CC" modified="2025-10-08" version="1">MPLSDVYSDQTSGIAVAYDHVPRATSMLHSQESASNDTATVLSAHLLVSNTPLAPSIAGFILEKHHIGDLSLMWYLMSFHPQMDMTISMALSMTAGISTSIMLETALLHLGKDRMPLTVAARTACGMSLVSMLSMELTENMVTLGLSDNNMTLASKEFWLVTCVSMMAGYLVPLPYNYIRLKLWGKACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMX9</accession>
    <name>A0ABR3BMX9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612190.1">
        <property type="nucleotide sequence ID" value="XM_066759543.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991941"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="252"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="484"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0243823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="617" mass="68635" checksum="5FD9219601020A36" modified="2025-10-08" version="1">MPFNDELDTPAFRAWLSRTIEPLCDADPTVLSDYIVALMKHDASMTEDEWKTFISRELVDFLESSSGPFVETLFQTLHSKNYDLTQTLPAPAAHPITTGPAHPIPTGPAAEVALQPSAGPSIVQDAQQKEQKDVTMQEMPVGVSGRRKCRDYHERGYCMRGANCQYEHSADMLIPTPEMMFQGFLPPFMPGMPGMPMQYPGMQPMGPMAMHGPGFRDGPNSRNRSFGNRPPPSNEGESFEGTSRPPSDHGKTTLLITDIPDANMSVVAIRNYFQQFGTITSVALEGRGNRALVNFASNLEAYKAWKSDEAVFGNRHVKVLWHKPRPGQGAAGQKALEQSKKLLTNLQKMEAGEELNQGVKPKLSGPETRLQATLAELEHREKQSKKEPLIAEQKVLLKRASTGTKEEKVQILKRLREITKELEIINNPPPKPESMDVDDAKSRLDRELAAHGMEMGGQDEEELARLNAQLASLKEKANTLGVNASARYSPYSRGRGGRGRGRGGPPRPMRLDNRSRTILVSGDRFADEEARRVVQEWYEATGGGVEFVDGNLRITYPQREMAEKALALGTNELREKAGPIRTAWEPPKPVERYQPSDVEMTVHMGEEELRGEKDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN13</accession>
    <name>A0ABR3BN13_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="9" type="ORF">I308_104580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612537.1">
        <property type="nucleotide sequence ID" value="XM_066759050.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991436"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0245453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="284" mass="32011" checksum="6104370F879D4110" modified="2025-10-08" version="1">MLPTHSTRSPISTYPPSFSQLISPRTSHSFPCSQLPDHPPALPQNSNRRSSRRKRKKFTLKTFQSVLYHSSFWLCIIIETALLVGAAWGLGEQAWHTGPQQGWNIVVLAAAYAVFLILTVTHAWSRYLSVKQIMKTMPKPYMPIKPDDLPEKVSRHIATEYSRTAVISHISQATQGEQDGWGRPGTKWEATWLREYILGTVGVMKEALGVGDGPPLSLTPFYEAADRLDDSGAVRLLVNSWAKYVEKARYGKKEPNEREAGAVERLVEVVVLTMEIKRQKKENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BND7</accession>
    <name>A0ABR3BND7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104712</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612664.1">
        <property type="nucleotide sequence ID" value="XM_066759177.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991568"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="9">
        <location>
            <begin position="1736"/>
            <end position="1888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="2021" mass="221092" checksum="EC06660F7793F8BF" modified="2025-10-08" version="1">MSSLAQQLQSIASLDATRLTSAYGAPSGKSYVFPPDVASSHDIDSIFDLAQSGFDELLSLDPEMEEFEEELFSEAAKRTDRMVLSKEENDNLDRTLGRCLRRLSKWIRLMAGGKCIEWLVRRFRVHEMNVDEVLRAFLPYHESPNFPRILAILTIPKTSPYYATFAPLVKNAQPIPRSYIVTSISPAKDKSLVLLGDIASMVQQAIKEDVVHHALLTFWTATMVDLLEGARHGKGANEGVVKQLVESFVTLLETPKAGEDVNAAVYPPLVLLTRTVPLADEPFLAIVSSLLTPGTGSNPSQRMLTLLVILNDRPVWSLGLGEHATENLAKVSQLGGILVAAMNKYKFEKALNIVVKSMLEKPGLHAKALATVLEHESLPVSVTELASTNLLQLGSSTDSEEVKAACKSLLTNLRERHPSIVDTAFLQASASLEIDAHPVDHDLVQKPTEEVAFLDVYAADISSRVAGVKSVIKMAKKGEEIESSITALEARLSDADENVVNALYEEPKALLEILPVEKYIAGVKPVFWAVSPIPHIIGLHLDFISQYLLASHPEAGKQIYESLLFPTFLSTEKRQPLTKSQALKLLNGGFKKLDKLNKIGPEIGKAREEGMKGAQRGNLVIARALADATVASSTFEDDVSFLIAQLDSTTSSARLLAYLILHSLVITIRGPRQLSTCLSILKYLSPRLAGHFLRDLKHADENVNTVYMESVYKKTEETRTTLRATVSILAAMSKVTKPGGQIVWLSGESKAKDASYKTFAQQIYLWANTAILPANVAQSLLRSLLTQLGEEALLFLSSVWTSSTSPAPLRTSALKHALAFIHAYATLPTTPAAQGQPVDFQVILPQILIALQDSDKDVRRVAVDVLRSVEGGEGMGDVYALDTVYGDQSEMTQLLKSIDRKKYIETLVEVAEEFVIDPLRLKAFHTEVLNMQSGKNRKESAHRRAIIGFLMSHVASYRAIHARLVLLSLLSDVHDTSILRSAIPLLASLLDDKSEESIWLSSTPDGQQGLYLQALMGSLKVQSISVLGEAGGEGWEFLLNLLDASKSSRFVARLRILSFKSMVGGVFSALGPQQQIEYITALIQCIHALPTNDALDTVKVLEKLDIQPSILIELIEHLSDPLEMSVNRKRQRQDAADDDKPTQAVHELTTLVDSRNWPSIPASASLVASLMSILSALLTKRLIIKEGIDYLEQEVLGAILALVERITDAQEIQRAHVGIEVVIKVIRASTNPRTAQRALLVASELARLIPDAVLHNVMPIFTFMGASDFQRDDAYTFGVVEKTVSRIVPVMTESLKEKAQSSLELYTESLTFLSIFTDMAGRLPRHRTLPFFVHLVKSLGASDYLAPVCMLLVDRATTKAGRNKESVSNVLELPANLAAAFDVSVKTEALGEIVQELARLIGDLSKTDKEAFLSQTISENDATDRPLRQVTYLLSFLSSLLGQLRGKACSQAPVQSVVRQLMVLAASTSQPVMATTDIPANLHKALASTMLLLSADNFLGVTAELLSDGSEQDIIMSLGVFAERLPLIKSEVRLRCIKIIAEILKKIGGLLVAPGATVSAALEAVKSVTKTAIAQEDGSLASVLPAIVGCVGKVKESAVVVAALSLIELLIRRLAARTIPIIQSILDTSLNLIKSTKSAAAVTNRAFVTLSSVIETIPTFVSSKQLSAILITTIDYRTVEETSPSSLFTTLAKKIRTKSLFPVLIEVWKTVQEKGGDSEMKGFFDMLRLTLKNATREDLPSMLKPVFAFFLDVFDLRHRLQLKAVDTKVINDVEESAIGSFLELVTKLNEPTFKPLFIRLYDWAVIDLAEGKNVDNERLTERKIVLLHVMMGLLTKFKNLLSPYMGTLLPHIQELLPAFSTGSIRSEPLWTLLLNVLGKSFEVDSGAFWTDALEIELLPQLVAQVPLFLSIAPSSQNPRPISSCLASLAGSTTAENVLRRLNTAVCLATRSDDPKARLAALDALGAIWDAQAEEMVGLVPETVSEFLAELLEDESKDVEIAARVVLAKIEKVTGSLTEYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNK4</accession>
    <name>A0ABR3BNK4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612724.1">
        <property type="nucleotide sequence ID" value="XM_066759237.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991630"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="393" mass="43907" checksum="A0DADC40F44F9DF7" modified="2025-10-08" version="1">MTVIQQSKLFTPIQVGEYELKHRIIMAPLTRLRAATKTAIPSEWAETYYAQRASDGGLIISEGTFIAEELRGYENVPGIYTSEQIAAWKKITSGVHSKGGRIFCQLWVLGRVADPNVVPVIYSAGTIRDDSPSYIAAPEPGGERKPLTPVTEADMDRFIGHYIQASKNAIEAGFDGVEIHGANGYLIDQFLQTNSNDRTDQYGGSVENRMRFPLRVLNAVCDAIGPKRVGIRMSPFSEFQSMRMEDPLATFVPWAQAIVEAQPTLAYIHAVEGRGFMTPQNEWFIQDTLNPIREVVLNKGKSVRFMAAGGYMPDTALEHAEKNPEDLVTFGRYFISNPDLPNRVRNGWPLRKYDRTTFYSQSSVGYNDYEDYKPETEALAQDEAAPKEGTTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNR0</accession>
    <name>A0ABR3BNR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612791.1">
        <property type="nucleotide sequence ID" value="XM_066759304.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991698"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="302"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="956"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="690"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="883"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="963"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0245707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1109" mass="122649" checksum="ECFF20E0B3CC91CD" modified="2025-10-08" version="1">MSISGPISRRRIGSGSRRGNESLPQLDIQSIQMPSNPQNALALKTAALSTSTRSLHQICSILKKRLLCADGFQPFLEQPPNAEPLDVVSHMCHLFRLGSPLCHLYNLLIPSFIDPSSPLYADLPAPPKLEYDFPQFYDSPNGVRNWAKRPENAKPCQRYIAAFCMAMTKRIGEGRWTSDMWALHELWGESTGEAIEAYDSTGLMKVLSTVEEMLDNLPESAMSPMSPHTPFTTSGSIAQRAQSRQSYDLPFSMGGIGPGAGAVAHMAATMNGGVHIEAGPTDNSPTAVEMQRGLSTSLAETNAFKSVEELVASEKSYVQELEILVRCSQEMLEAQLVSTETNHQIFSNLSKILDFHRKFLSKLETEYEPIQERGPGAWAEGIWGRPFILSEAEFNCYGPYCANYLDAITVVNEQMTILMRGQELPPAERPCLEPQRELQAFMIKPIQRITKYGLLLDAILYATAKHEYPFRPELEEASAAVKRIAAGINEAIDFKAKQATVRELVERVENWKGHDVGKFGPLHIDDHFTVIKADQPREYHVFLFEKMMLCCKEIIPEGKKQNKNLRKDQGTSETEPPEKNKLDLKGRIFVSNIKEATILPSEPGDAYGAARLLVGWTIPLRNQDGYHNDQKNSFVMIGKNEEQMRKWSEKVMELANNERKIQEDMRVARMKAGRFSGSERQYYQHSSFGPPTPATEHPPTPFNMPPLPNGAATPYYSEDEDAEGLRSGRTTPSIQGSYPHAYSGQPSAGRRVQSQQSMASVMPTELRARAMTEDQYGPNMTQWRTQQPMAPPLPRLTSAMSGLSMASELSFGSGPNSASVRTGMVRQMSSTRLPRTTEVEQGGLENPMDPRDSYGRYGSLRGMTRAPSHALPSVPHPPPLRNRSASSPNVYQQPTVTGAASLPYTAGPTGTWTGSPLASTLQMSTHPYVQSTPVPGFGPSSSTTLVGGTAYFNKRVSNGKRSSGGSHHSTTTTDTSDQTSPATPYGSGSGDVRGSLRQNSGDNVSGSVLVKLRFGSDQFILGVSQEIDFLTLYQKIHKKIRLCSSVNRPANEHDKLQIRYVDNDGDEIQVKFDADVELMFEDARDQAGHINLIARWADDRRGTPQGEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNT2</accession>
    <name>A0ABR3BNT2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_105890</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611643.1">
        <property type="nucleotide sequence ID" value="XM_066760339.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992745"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="146"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="12">
        <location>
            <begin position="1317"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="606"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="775"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="838"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1059"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1218"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="612"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="792"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="849"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="912"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1059"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1074"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1091"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1111"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1220"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1251"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1294"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0242261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1370" mass="148848" checksum="552731F5FF78D230" modified="2025-10-08" version="1">MAQPQVYYQQPSPDFYPQVRGHNAHIMASNSTQAGPSQSAGNSAFAMPDVRQPKSARPRPPPSSATMPMIPTSLADSSMHSYVPVQAPAAQQMRTANRRSHNPAAILNSPSAPRPEELTDEYVLHPSVYAFKQEYPRRAMVGLGPYIVLQTLGEGEFGKVKLGVHADYGVEVAIKLIRRGDLQEEAHASKVEREINVLKTLKHPNIVRMFDVLDTHKYIGIVLEFAGGGELFEYILANEYLKDKEGQRIFAQLISGVDYLHKKGVIHRDLKLENLLLDKNRNLIITDFGFANQFDLSKGDLMSTSCGSPCYAAPELVVLDTPYHGSAVDIWSCGVILYAMLAGYLPYDDDPDNPDAGNVVELYRYIMNTELHYPDHVSPMGKNLLQHMLILHPEHRIKIPAIVKHPWIKSYHDMFNKSVEECEAAFQDAMYRKSKQARKELQERRRVQIQARESLQAERAHVQRSQSVAPGTIITAAALDQIRRRPHSAIPGSAPLHETIAKHSESVDDAPLTTRPATPSTTLSQSAEIRSIRSSAITEAESMAPGLSFTTSISVPTAMTVETPSPVPMQSPIDTLPPVVITAVQPLMEAVPAARDHQTRHTIPVEYAGKTSYDRPKGTFDDSHGRVEGSTETTSTADTVMVASSLLDVKREESSDVEMESGSSDSEQPKTASDDKSQQTGEKAMASLIVPTTAPLAPPADFGTATATNHSSQAVEPLEMPMPVPAVEHGSDAIDEMMSPSTPRISTFVEQEPVNVTPRAKMRTAQIATTPKASVVNERKKHGSVPPPMGASSVSISRPESSLTDIGLPKPPKKDRNRKGMSLDKFGLAKLLGHASQAHTTVHGEGKMAPPSASSSALALQHQLQQHGGQSQATSESDSVKKSRRRTLQFGFHSRKDSKASSAVTTPGVPLTDKDTNDENRLSSTMRDKRRKTIQVGLSTQSEQKDTAVNVSGLPSSGHLVKNPVAESLQGVSVSPGVGTKASAPEQSSPSVVAMDAFASQQGPYSSYRGSFSRASKVMDWFRRKTLVKETLPEPKSPALKSDSQSSFVRIGEVASTASKAQESAQASTASHGNTDKTEETKETFDSTTDQENNTKTTPTKSSVLSRSIDATTTTPSVTVTPRPTAATTLTIGTSTQQSPPTTIRTRSASTLFDESRIRVHNGLVDQSALSTKPPQDVFMEVMQVLRGMGVEMKRESDFKLRCTRAKKKAAGTSIGLGSVISTGSGMSPFSIMNNASTSKTDSRGLPMPTSPSVANRSSTGIKGLLRRGSSRSSARPARFNRTDDEVPNPPSQSTPNLELTESSTTSKPEPLYGKELMDAGDEVKFTVELCKMKNLPGLFILKIKRTKGNLWSFKFIYQTVIERTTTLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNW3</accession>
    <name>A0ABR3BNW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612847.1">
        <property type="nucleotide sequence ID" value="XM_066759360.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991755"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="932" mass="99605" checksum="B31D235B65B2F8E2" modified="2025-10-08" version="1">MNYLKSITTSVLQSTGVTFPFSVGERIPGLDSHSSIWEIREGVKRDDGTPLTLFIYDSTLPPFQPGSKDRKVLFQLAKNALKKLRTIRHPDIIKYIDSVETETHIYIATERVRPLEGVLRDWETGGALASGAGRAKGKENWIGWGVKSVSSALAFLNSPPLSQHHSYLLPSSVFVTPSLEWRLGGFELLTGKDDVGGILWALGGVAPGDVGEICAPEVRKSGWSALRETDPAQHDTYLFAVFLFTLYNPHSPLPPLSSQPTPSSSGALPKVLFPLWKRMLNPSPRTRLTTISFTDEAEKAGFWTSNPLVSLVKGLDNFELQSESEKLSLLRIIKEATQAGTLPGPFTTYKVLPSLLHSLSLPTAPSSAMLPLVLELGKLIPSSDYPKMVLEPVVRLYTSPDRGTRMALLEGLNEYVDKLDNKTVTERIWPNLITGFADTVPVIREATVKAVYPLASKLSDRILNNDLLRVLAKMQMDTEPSIRTNTCILLGRLAPILGHNTKKKVLVPAFARSLKDPFVHARVAGLMALMASVECFDREDLAGKVVPNMSFTLVDKEKLVRDQAFKAMNMFVSKLTDMVKDMPESTLPPDQNSSQGPVTTTSASISSNQGGAVNSAAGAAGALAGWAISSLGKQLKTSEVHSSMNSSGMPGAFGASAPPVKVSTASSSPAAPASSRVSEEIFRPASASSSLKGVSTRPTVVNTFGRTTTSPSLSGTSGGMKLGGAKKAPGKSLADQLAGEWEEEDGGNAWGTDDLIDVNADDDDWSAFESAPVPEVVVPPPQPYYVSAPKPKPTSSNITTSAALRSKPTLSPAISATSTIPTHAPESVKPTSSTSTPLIPSSPALSSFSGAKSPALSSNAATTDADRGQIDSAPASERSSPQLSVKAGNGTGTPQPSLANMSKEEKEKEMARRREERKARIAAMKEQKKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP06</accession>
    <name>A0ABR3BP06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_104628</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612580.1">
        <property type="nucleotide sequence ID" value="XM_066759093.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991484"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="202"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="449"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1036"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1165"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1326"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1369"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1407"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1036"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1177"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1377"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1416"/>
            <end position="1426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0245496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1426" mass="160386" checksum="3C367FC364CD218F" modified="2025-10-08" version="1">MDFEEDQPLWGGSRQEEEEDFEKSGPAEYEFPHHPDDSPTPRYKIGLPSRSFRPEQNLIRFGASQFNPSRHTPSPLISGSHALLTGVTLDRNTRRPTPENSLDRSRSIILKRQQSENYGEEIWEDEEFVEAANESYNHEINNAKEYDPVITAETVRDREELRNNAIFNKNGKPLVPLSRLPMDQRKLFKFPCFNKVQSEVFGDVYESDENLVVSAPTGSGKTTIFELAFLHNLSFRTPNDSPKPLAVYIAPTKALCNEKAKDWQERLGQALPDVICTEITGDYGNTSTIYNSIRGADLIVTTPEKFDSMTRRSRNLGNMAQRLQLIMIDEVHILRESRGATLEVVISRLKGLSRDIRFIALSATVPNIDDIARWLGPTRNEYGQLSRGVLVGREVINAKEKRALTVDDMPMAKVYKFGEEYRPVPLQRVTYGIESAGNDWALANRLDKELYPILLKHTAGQPVLVFCPTRKSCQATVESIFQSYEEARAKGLKLPWKHPPGVRLELQDKKLAELSTCGIAVHHAGLDYADRRAIEDGFRDGKLHMIASTSTLAVGVNLPAHTVVIKGVMAWQGASSGFQEYSDIHIQQMVGRAGRPQYDTSGVVVVMCERSKVRKYQSMLNSQTVLESCLHENLTEYINSEIGQGTIKSVSSAQEWLKNSFFHIRIQQNPKYYALSDAKDKPVEGAWEEWLDHYVEKDGFIERSDDDTLTPTETGKIMSSSMISYGTMCSIKAMSPRSTVQDLLEILAGSTEFKDLRIRQGESSFLNKLRTNEEIRFPLAEAVKSYADKVFLLLQVTFGNIILEDIAKKTELTSPIQTLMAIYNHGPRIAKAIVQFTLNCEYGVAARSALELHRVVVGKAWEDLPTVFRQIPSIGPKSIRVLGQNGVTNFDQLLDVESEKIQLWLNRGHDFARAIHEQARRMPRFHVTMEEENMDYDGTYNVLNLRVNIAPKTKVIATESKSKRGGFITQYNLSTLFLSQTGRFIGYRRLELKKLIKNKDNSFLIAVTLNKRCDSVTAIVGVISFNTDLHESVYPEDLEDDEDIEPPPSQRTLVEPTSGPKEELLSNGNLKIEFVRDAVCRMRQGSRMSRSPSLASNIQAVIDKVQIISEVPPDTIAHIVRRTISPVVAAQPRSRSNTPIVPVRAVRDIANGKIKEPLFLPGSDGQYNVKYEDDPSQKSSARSKALTGSTSRYFDQSTASRNAKNALSYKTPTTPDALVASHPSILDLLPEHATIKHDSDVNSHSFRPMHGIFSDDGYETVRESPDMKHSRTFPRPKPSVDRYTEEIMQDDLEEHMEANKSHGVTTKKQAPENWEFDIEEMFANISGSPSSPKELEEAPKSVPNTKLSPALKRPARLIIGGFGRPSIKRQKLHEDQYSTSYSPAQPSTQSENPDILCADAKLLAAQGPSTSVPQNEMEEFENWYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPS0</accession>
    <name>A0ABR3BPS0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612991.1">
        <property type="nucleotide sequence ID" value="XM_066758543.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990919"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="7">
        <location>
            <begin position="326"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="328"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="682" mass="75556" checksum="CCEC9352CAAD61D6" modified="2025-10-08" version="1">MNMPIQLTNLYSIIIAIHSPASETQQQERQHPQGADWRLGDITVDWVDFTREKSVGKRDMPRNQHYSSQESKNRLTPQGRSVPGSSTAVSNSKPKTSRSQTPTQHKPSKDDPDSLSLQPLLAHFPSPTPLSSSYAQGISYLGTGVVHLFRHAPPPSLIADIDNHPFGSSSRSAGEASSKQGWSGESAEGEDGSLIAILAVPAWMRPADFLEFIGGWGTCLEGVRMIREATTPNRSIVLLKFRDPLQAQDFTVIFTGRGFSTLDARETCHPIRIHHLVLHKLDQDQAMSQKNSIAIPAFPSSVYASRAKQLPELLSGVPTEKRYELPSCPVCLERLDSTVTGLVTLPCAHTFDCDCLRKWGDSRCPVCRLSHLLLSSSSSSAAPSHSLHEREITRLTKCIGCGRYEPGKGHARRHWEESGHVLAMELETQRVWDYKGDNYVHRLIQTKNDGKLVELPSASSLVTPSVPRVMPLGNSQRPTSPTSAARSMDICSTSEHQSQAHVQGHAGPSSNDIDKISTIESITLEYSYLLSSQLESMRQHYEKSQSTLETRLEELERRGRETEEKLKGLEKAEKERQKAERKMEKALELSKGLQSALGAERAMSQGLSDRVKVLERERDEAVKGKKDKEAECQMLEETVRDLMFSLEAGMKIKELGGDSGEGGDLMVVPGKESNKGKKKTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPS6</accession>
    <name>A0ABR3BPS6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613157.1">
        <property type="nucleotide sequence ID" value="XM_066758709.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991087"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="329"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="676"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="76489" checksum="CFAC018738781770" modified="2025-10-08" version="1">MNPPAATESLSDPLPPNAARRPDGTLAAPEQPSVSSSSSSSSNLATPAPPSRPSTLAIPNAPMQNPAAKGIPAATPASHATPLVGRGDAETGGSVKGIVDLSEFDPYATPGPTTTISAGAKKSSSGGGGGGGGGADEAVKALKGLQAKQDGDQEKQEENVRVEEQGVDVDMSPTGPSQTVAARPPSKRQVQASNNNRPTTPAPAPATGSTSTARDQEASDKEKEPVFNFQGFLKDLKQKSAEPVARYLKSFLSNFVKKPFTVNEQIKLVHDFLAFISEKMVQAEPWKSQSSAEFDNALEAMEKLVMNRLYNYTFTPQLVTSQPITTDDLERDRVFSQRVRLFGWIREKHLDVPEGEAAQGFLGFAEQELLKINHYKAPRDKMICILNCCKVIFGLIRNVYGAESGGADAFIPILIFIVLRANPENLISNLEYIQRFRSTPKLQGEAAYYLSSISGAIQFIETMDASSLSNITQAEFESNVEAAIQALPPSPSAAAAPARNGNGNSTTSFGGFRTPGRDEGRERDSKLISLSPFAATTPGDEAARPLSMASAAQATSKWFARTGNLAQEAVSKPLNAIGKIWEGMSPADTRQGSEDGSGGEGEREREGERPGGGVVPRDVFGSRRFRASTPESPSRRPIFGDEGISRTGTPSSELPDFSALDIQSTIDASQETYAQTRLANVQTLHQMFPALDEEIVEAVLEGCSDDLGLAIDRLLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ43</accession>
    <name>A0ABR3BQ43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104334</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613259.1">
        <property type="nucleotide sequence ID" value="XM_066758811.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991190"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0247298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="227" mass="24801" checksum="C8DE5844943E2B3C" modified="2025-10-08" version="1">MAKNTKTATKTAPRVVTQSSPVQPAPAPTDSLATDPLPTVTVNNANIAEIKSALDDIFKTYLLDQSFTPSLLHPTVHLALGYSSVVLALSSVLYSLRVSFEDSKPVLWVAVVGYSLLQTALWGWKRWVEKDEVFKGKRRRMVKRIETDHLQVITSTQLATRYVVHLALSTTSNNGKSLIHKSRVVVARGVGELVDEDGGVEEGEVKRWLAGVLREAGVVGVDGLKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ66</accession>
    <name>A0ABR3BQ66_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613295.1">
        <property type="nucleotide sequence ID" value="XM_066758847.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991226"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF6">
        <property type="entry name" value="EISOSOME COMPONENT PIL1-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="688" mass="73783" checksum="BA72F9301CB4CBE5" modified="2025-10-08" version="1">MSVRNTSGKFSLSSFGRKVSGIDRASSPTRDSGSNEDDHSPVRESHGAGFDGLGKKLKGSLAHNNLLPALGHKDLRALQDIISSEKGVLQMSEKLAAETSKASASLPPYGIQEGPDLQNILTQSSNLLSNLSTALNVFAGHQAEMRACLKRVREREEALMELKSRRKSTGAKAETAERKLAKMGPENKSLPQQTELLERLRSDMRQMDQDITTEETKIGDFKRQALKEALSYKFGGLEELGEKMCIIGELGKLLLEEVPLEETPVGYGRAPYAGYEKTESAVKEATKCLATVQFHAASSNPKPPGLPEPGFAAPLRTTSIPHDERSIAVANEYADYPANTPISPEGKGKQRETYPMDAADPYGGIGKDPYSPETTNGQHKIYSEFGGTRQVMFQDPNNDHPSTSELAIRSAPGPSGTGHEEEKVHGYEYEQQKQMDAEDAWKKLEAEEAAWKSQETVETQSNPHSPTETIPATVPAPAPQEDGDMYAPWQPLNLKKENSAESPATISRDGPVPVAHSPTLAPIPLGEPTNPAPVETEDLPPSELVPPQPAWRAGATPTPGASEFHTPLSSPNPALDNTGLNSGSVDKEPAREYFPSNMGTGGKISAAAFRKGTKPKTSLGPEDSPNTSVGSPVTSIGEVRRLPIPPSGPAGIELPASPVSGTAKLGDGYEEGRMASPPPVYQSEESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQG3</accession>
    <name>A0ABR3BQG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612480.1">
        <property type="nucleotide sequence ID" value="XM_066758993.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991375"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0245396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="276" mass="31867" checksum="D3F5833949931722" modified="2025-10-08" version="1">MADKPKAERPSWNKEEFATKAKEKDQEAYEHAKAAEESLAKGHAPKKQSQYDDLPKPTELLKARTEDLGLTKNLNKTMLVTTSTTGKGPRGAGFYCELCNRTFKDSLAYLDHVNGRLHLLKLGQSTHVERSTLSQVRAKIASLRAATRQKVTAKNFDFQSRLKAVKNAQEAEKERRKEERRKKRMERERREERRRMGILDDDDEGNGDEKGEKMDVDGAEKHAKNGKKDKRQERKEKREQQERDQQRDKEVEKAIRENEDMSTMMGFGGFGTTKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQH9</accession>
    <name>A0ABR3BQH9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066758952.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991331"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="59"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="376"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
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            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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        </location>
    </feature>
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        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="427" mass="47258" checksum="FFA854DAC97E671B" modified="2025-10-08" version="1">MPKPIPQPVAPFSNPHQDEERTVHTVYEAIAPHFSQTRFKPWPLIARFLSTQPPGSIGLDSGAGNGKYLPVAHQAGCEMIALDRSSGLLSHARKMGFGGLNANRQEDGKEGTEDRSELAECVRGDMGVNVWRAGVFDFVISIAAVHHLSTPERRQHAVQMMLRPLRLSSQPPYGRFMIYVWAYEQGERSRRKMGSAASAAASKPGSEVPCSVVSPLQEKDEGEEQEKEKIQDVLVPWVLAPKKGETSKKSKQPKQPTSKKPKQAMEKHHYLKEPIPGGKSLHNDSSCPLSGYELQSGSSFSGPTRLSEPQAEPEPASKPEPEPEPQVFHRYYHLFTTGELQLLVEAAGRAEGFQVIPSQDGGDDGNQTKIEIETEDEGNRDRVEGSVVEKEEAAGKWEGGREGKWLRVRGVGWEMDNWWLEGEVGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQM7</accession>
    <name>A0ABR3BQM7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613461.1">
        <property type="nucleotide sequence ID" value="XM_066758059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990421"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="880"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="357"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="578"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="880"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1263" mass="135761" checksum="767D3E2BF05B2D50" modified="2025-10-08" version="1">MSDLYDDDDDFFDNPETLNLLVQVEERALQASQAQPMASQLPLRHNTVATDNYSSGRPKQLGTRRTLPQPQNATSNTRSQWKPPIPAGVGAGAGAGIGGSKSGHGEDEPPPIDIVMDGAGRYDLANPAGSGEEAVVTDNRRSKSLALGARLGLGHGRSGSTSSIGTAPRGSQGQDGRSAASEERRRAITQALSGGEGGKVLSRSNSTSSITAPRPSHTPAAPGQASAPPPPHRGSHAFNPTRQLSRSASVGSHAGSQVFGGGGVSNRPSPLQGNVRLLPISSGGGSQGSQNQGYGNNQAEELKKERERRVALEMELARLRPGAGAAANPIPIPSASVSVSTNANASNGPKVTVGPEADDLEKKVKELQAQMWAAKGEAETIRRAQKEEKDRFKAELERLQQAVAEKEAQVKEKEIQSKRMIETVRHQAIFTNHAVQASAVKPRPQASQRASTSSQFPRHLPTPARGNSTGLGGGGGGGSHVNATPLRGAGHGMSPAGFGADPDVTPLARGARESHNRRPLLGQTPGRPSSGTQGHAAFYNAFAATPKLVTSVGGPRKKLKTSHETDERDQDRERERSSPQQQPSPSRSQPSQALPTRSQLFRDSHSSPTKSPRGSPSKAGARGSPARHLRMGGKGKERAREGRESSPLRSSPSRVSRRGSSPTASTMEMDDEEQDVDWEGDGEREETDHRGELLYQLFNHTPLSSYQPCLLSYTTEPSLYRILTYHPPIQPSPNHLHMAEAPGSHLPQDQNHRPGPKWGQKYTMQCYELLKTCGTGEMDDFAVLAQGVVRCLGGMLEALISAILSDWEKRGEDEGKKDISYYEITALSNLYDLLSSLAHLFPLIITYISEISVIIPATQRLVVELFSKEGKLEEMDARLQAERKRERRGSRQEEMKTDEAEGEGKKNADENEEEEEQESEEAKMEGRVFGAWGVELGDGIAGLCEAMCWYGDGPGIWQGSELVDIILGLTSPPLNNHTVRRGLEVFFAAAIHGNQFASLMSPTESIPGLARQPPLIERLSRYLISPHPNASSEEMLRMKLMIVKGMCMMAVSNTDAVVLMGSRTILVPALVLVLQEESSKIWGIHAYSTPVEDALALLHPSLSLLHQLVFPFPPFDSSSPSATLSSGSAANPNPTPQRYRLRSSQIDSDAPIGIDLVQVLQQTSQVKEFNGLQHMFVSAMGCMAYGIFGEGIGSQEGVGEADLRAIQVLSGDLLENVVEGPEGDVIYELYVPNEGAPPGGTEGDGDKVQVDEDVYQEMDVDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS04</accession>
    <name>A0ABR3BS04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613889.1">
        <property type="nucleotide sequence ID" value="XM_066757505.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989859"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032633">
        <property type="entry name" value="ThiJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF22">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17124">
        <property type="entry name" value="ThiJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="174" mass="18907" checksum="527CE84B2C912759" modified="2025-10-08" version="1" fragment="single">MPPKKILIIMSDASAVPLLKTSQCGETTTDQSTGFFLMELAKPLSKFLSAGCEVTFASPLGKTPTPDPNSESLMAFALNFYERKRENDLIDRMKRENGFTSPRTFQSISDEELDGFAAVFIPGGHAPLADLGSDPELGRILAHFHHEGKPTAVICHGPYGLLSTKATPEGTFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS29</accession>
    <name>A0ABR3BS29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Oligopeptide transporter 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613648.1">
        <property type="nucleotide sequence ID" value="XM_066758246.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990621"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="690"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="79076" checksum="2BA1AF85AE0132BB" modified="2025-10-08" version="1">MNPVSPPSSRGMRDYIPQSMEDEDLDGEYLDMEVPIEGDFTLRATLAGLGVGVVLCMTNIYFGLQTGWVSMMSLQSALLGFAIFRVPAFLPRLFPSMKPFTPQENVVLQTTAVATGTMPLAAGLVGIIPALSMMSPEIDGREPLFMGWADLVMWCLAVAFFGVFLAVPLRKQVIVKEKLVFPSGTATAQLISLLHQTTPVEVHGTPTRAYRRLRRSSASVSPSRSRRLDNDEDEEWGDAREAEGEEEKGVEIMTGKGWWALGTSFVASGSLTVLSFLFPILFSIPVFDVLSLPFGSSLAASWMWWFTPSLSYIGQGIIMGFPVTVSMNIGMVVGWAMLSPLSKHLGWAPGPVSSTTDGSRGWILWVALAIMIAESIISLLPITVSYISTALRRYRQRNYRSGIFASEARSPSRQISGEEDYFNPPDKDEEPEFEPPERLVPSSWVSWGLGVSGVMGVVLVWVVFGSDGIHPWATAIGLLLACILSLIGVRALGETDLNPVSGIGKISQLIFAILQPGNVVANIIAGGVAEAGAQQAGDLMQDLKTGHLLRASPRSQFYGQMIGSLASVFVATAGYKFYTSAYTIPGPEFAVPSAGIWLNLARLLNNGHLPSHVIPFMLGFGALFAFVSFVKVFRSSFPASIASSRLIGHLPSGIAFAVGFLNSPSFSIARLIGGYIAYRAAKTTGTGETPLLVIVVASGFVLGEGVVSVITLGLTSAGMGAISCWGCGINGGGYCSGGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS60</accession>
    <name>A0ABR3BS60_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613678.1">
        <property type="nucleotide sequence ID" value="XM_066758276.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990651"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="85"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="492" mass="57564" checksum="52F70C6CEF6B1223" modified="2025-10-08" version="1">MGLTQSTMRPNGPRRGFLKVSGKDITLDGKPIRLRGTAIGGWMNMENFITGYAGHEHQVRDALKQVLGTEKYNYFFDKFLEYFFAEDDAKFFASLGLNCIRIPVNYHHFEDDMNPRVFKKDGLKHLDRVIQICAEYGIYTIIDLHAAPGGQNFDWHSDNPTHKALFYEHKDFQDRTVFIWENIARHYKDNTWVAGYNPLNEPSDEQHVRLVAFYNRVEEAIRDIDSKHILFLDTFAADFSRFGKPLHNCVYACHDYSIYGFPNPPSLYEGSKEQIQFHIDTFNRKTEYMRKHEGPVWVGEFGPVYQTSEDGYPDWKHINDTRFDVLQLQLDIYAKARASWSIWLYKDVGFQGMIYAGEDTAYVKLLKEFLHKKKFVAADKWGADDRAVRPLFEPLESWLLKTVPSISDRYPQDWSVGEHLSRLVRNMLLSEELVKEYAENFRGKSFEELNELAKSFKFSNCTKRKRLNDVLKSDSEHGTDEKKSLWQVDEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSK2</accession>
    <name>A0ABR3BSK2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-binding cassette transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103233</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614117.1">
        <property type="nucleotide sequence ID" value="XM_066757733.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990089"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03369">
        <property type="entry name" value="ABCC_NFT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1056"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1098"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1185"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1234"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1288"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1312"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="349"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="713"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1078"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1376"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="443"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="949"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="965"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="986"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0249930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1650" mass="182622" checksum="BFAAEE22AD689F05" modified="2025-10-08" version="1">MSHILPIASTALIPFITLTSFTIYLTTHPSSPIKHIIRQQRIALPVHNGEALDGTLDDKDPFDIDDPIVCEDGTPVEPQQFWTSMWKRKLAVIGLMIPPLICNILLLTFSLLAPSNDVEDRQRNIILPALLLPSQAVTLIVAFWHLSQNEVSSHWPTTIHNAIDIFTQFIILAFLALLPSSPLPSPPASPKLLRAALPDIYSSSPLALSKALLPVLYLPPLVAILSVRRGPPLYLPLDAIYPSKIISSVPPDAQSLNPQKANVSPEVQATIPEWLLFSYATNVIHKGYVSESLDVWDLPILPRTLRALYQFKRMKRAYGKTKGHRGRMEGFNLLLTVARVNSGLLWAQTLLAAATAFGYYLPHYLLKLFINFLENDPGRTEPAWGWFLCFGLFTSNALIFIASGVTWSICTTYLQGKIRLQLNTMLFKKTLLKKDIAANSGDTGQVGGVQEEAAKKKKKKEETGDSNTEDEEAVTSKTQIMTLFTVDVDRVTEFVFHLFAVIDAPLEIVVASFFVFKLLGISAMYGLLTAILSLPLNHFASKIVVRAQENLMKTRDQRTALMNEILQGIRMLKFMAWERSFERRVQSIRKNELSWQARNYQIEVAFNCIWALTPVVVTVVSFLHYTLVRGQQLTPSVAFTSVAVFAELRYALNAIPETFIQALQGFVSCRRIEKYLCLDEVAAIEENDGESDIILSSATFAWPRGETVFTNELATNAVSNAATPKTAFTLADLNLRFPKGKLSLICGRLGSGKSLLLAGLLGEADLLTGHVVCPRSAPDAMSKRSAKLPEDIWIISNMVAYVPQQAWLQNASIKENIVFSSPWDAERYQQVIEACSLLNDLDILEDGDETEVGEKGLNLSGGQKARVSLARAVYSRAGVLLLDDVLSAVDAHTAHAIMTNCLQGPIVEGRTVLIVSHHTALVSPAAAYIVALENGDVKFSGTGEEFVASNLSDELDEEDAQARPTDSEQKEEKTIEENSVKPANKSVLNLSSACTESAAPDSETSSLAPEDDKVVNLTLGDKQKTPRKLIEDEKRARGRITWAVWKTYFNALGGPIWWLLFILSLGMAMLVPVAEKGWLGYWTGSSLSPSETGHTTRYYVMGYSVITIVGVFASNLQYCIIYMGSLRASRRLHNSMLKSVLFSTLRFHDTTSRGRLLNRFGKDIEGLDSSTADNFVRSVAYGLNVVVTFISITYVGGLPFVIAGCVILVVYYQAGSIYGQTSRDMRRLDSVTRSPLYSLFGETVSGVAVLRAFGASNMALQNMMKLADTNLLAFAWSWTVNRWLSARFNLLSAVLVGLTAVAVLIAPNVNAAMAGFALAFAGTVCHDLLFVVRRFVQLEQSMVAIERLKEFTELLQEAPEYVEPRPAASWPEHGFIKVENLVIKYAPDLPSVLHNISFEVSPRQKIGIVGATGCGKSTLALSFFRFVEAAEGRIVIDGVDISKIGLTDLRSRMTIIPQDPTILSGTLRSTLDVFDEYDDVDIYAALRRVHLVKEENPTTSLGEQNDVENRNKNVFEDLSNPVSEGGDNFSSGEKQLICMARAILKRNKILFMDEATASIDYETDVLISKTIREEFSDSTILTIAHRIHTIIDFDKVLVMDRGNIAEFASPADLLRDHKSKFYSLCKATGRTEFKNLKEMALEAERKRTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSL8</accession>
    <name>A0ABR3BSL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613629.1">
        <property type="nucleotide sequence ID" value="XM_066758227.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990601"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40759" checksum="F5650FF67450749C" modified="2025-10-08" version="1">METPSPRSPSNKEIGHDGIAAECKVNPVRFQDMPYEVTKVIIEHANPSDRYNLLFTCKSIAMVAGEMLCEGRMIAWRGHYGLSTSQVQAIGVQELFAGIENTHSTEEKPFGRELKLRFLRFITYLNLENYSQAKFDENAVEMIIKALQELRDMGIEPFPNLVSVELSASPLSPPRAPELQREFDLTLVSLCRPKQVIVKSGYGFLELRSENVPYCDLKFAGGHLPIEVLHQPFSFHIIPMVCYGTRNRVNPPRTVTDSVEKSAEYVLRVLHQVHPELNDVERKHYPEDQLEKREKTTWVFSWELSRMNGLPWAHHDVSKVRDAVLKELPKMRDRICFLPRKSLQSDWAQIINCGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BST0</accession>
    <name>A0ABR3BST0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614198.1">
        <property type="nucleotide sequence ID" value="XM_066757814.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990170"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="91" mass="10249" checksum="F2909D54BE250771" modified="2025-10-08" version="1">MSRCVMRYAGGALSQAVQAPTECGAGYRRTLCCLMRQEKNMAPFTRRQAQLISQVHGEETPITGIRRLESFNAELGGFNRISEEHIMWKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT83</accession>
    <name>A0ABR3BT83_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase inhibitor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614348.1">
        <property type="nucleotide sequence ID" value="XM_066757964.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990325"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="31851" checksum="13B443FBFEE36AC1" modified="2025-10-08" version="1">MSPNATYASTHTHPSHIDIPPVSGDPQIAEDDLVITPDDGFTPSAAKPPPTRGILKNPLSNFIGSDGERIAGEHLQWDEANIALTEVQKDSLMKIDEPKTPFVRYDAINDRVLPNDIDVPSFDLENDRAPRSPTAPQSPRNSIGLSPDQVARNTFMNSQPPRRPSSSTSTSSRSPSFSLPTKDHPVRPGSSSPRTSTGSIHSANGSVSGLELGATAANTAANSGEVFSDSEEEMDEETKARHKEFEKKRNSHYSKEAAFAMRKAKELLQKEEEEEGDDDDEENAKETMDLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTF0</accession>
    <name>A0ABR3BTF0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA repair protein RAD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_102393</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614407.1">
        <property type="nucleotide sequence ID" value="XM_066756938.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989250"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="602"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="984"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="1146"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="281"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0250220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1324" mass="146883" checksum="74728B046F1AEF93" modified="2025-10-08" version="1">MQLTTAALSKLARKTLELEGDPTTPIPPFYVDLLEKHLRKCPNDTNFIAELAEPQNPNSTKGGNGFGLIVCMEDQCWKEVILSADPFRDDGGRKEGFGSFWNYQEHCKENDHIKGRNERCKKMGIPIQSSSFSVPSSSSHASSSRTSSTLNPLSTPASSSRTNQSYPIASASSSKSVSKKTSHPSILDALVPSPTARSVHSSSPMPSPQVFTTPGTTPAVISHNAAPHAKTIRTSASKKVYSSDTHRPASSKGGSRALTASPSSSSDIVNMVEEYIANAGSSTSRTFLSDRTPLAPLRQNANGVVPKREPVRQRNVSGTDDDETSLPSVIEQDMAFYQMVAPKREPIAVTATPSVLTTGVFASASADRTSYAPTGLPLRDFYSLLLNELKLGRNGLGIDAIPTEDKEQRYTAELQHLLKALAGGYVNPPIDITLIFPSLRSIIENGRLIMSRMMTNATGQLLKVPCGCGDASHTCDLRALSKDSGNLHWREPSAALHGSQSAHVGPVMPMSVGRAYATYSDDDMSDNDDPRDPRGLMYRYTQSVAESLAAFFSDNLKDFHADTDVDKALQKLGLSSLSDFLPGLKIKLMPHQVLGVSFMVEKERDQRYRGGLNGDSMGLGKTVQSIATMAANPSQDVKCKTTLIVAPLALLSQWKNEIESKTTEGLMKVFIHHGPKRATTVADLKQYDVVLTTYGTLTSESPSDKPSKNKVKSVDGCKEEGDIPVKNVGPLMKVKWYRVILDEAHQIRNKSTRATKACWALRAHLRWCLSGTLVVNSLDDIYPHLHFLQISPSAQWEHFREHISKLQKRYPKLATNRVQAILRVCCVRRHKESELNGKKLLELPPKTTKIVDLQFTDEERQIYTAIENKYKITFNSFLRKGTVMKHYSIMLVMLTRLRQLTCHPWLLRRKPNDICDVRDVVVTGNDLLAGLEAPMMDDISEQARASTLVGPEYVDRVKTLLAERAKRLEEAPLDGIDEAGDGECSICYEQYSDERITPCCHSFCAECLENIFNSAQGNADLNDDDVQVGRRKCPLCRSVIDKAKIFRASAFMPFENDDEDDEDDDWGSQAEEVDDEDDICAKLEELNDDDMSEKKKGKRKAVDSFVSKKKKRKFKGKDVEGAEDKLQDVNDEVSIEDVLPSTKMKKLGELIDAIIEQDPSQKIIVFSQFVEYIDLCSIFLRRRNIPHAKYVGSMKQDEREDTIKNFNRPMEEDKSPRCLLMSLKCGGVGLNLCIANHVICLDLAWNAATENQAVDRAHRIGQIREVVVHRLVVENTIDQRLMELQQQKQALSDGAMGEGAAAKLGRLNINDLIKLFGVRSHDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTP4</accession>
    <name>A0ABR3BTP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613989.1">
        <property type="nucleotide sequence ID" value="XM_066757605.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989960"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="400" mass="43594" checksum="D664EB2E2FE50566" modified="2025-10-08" version="1">MSTNVALLGSGVFAQASYVPALLSLARFKTLVLHTIWSRSESSAQTLHAKYTSSGAPSPQLLYGEDGLEAVLANKEIDAVLFVLPITKQPDLVRKAWKAGKHVLSEKPLARDVQEAMELIEEYERDYKPKGLIWRVAENYAHEPALRFAGDILAKTPELGPVLFWDIKFTAYVEDGSKYHATGWRTIPDYQGGFLLDGGVHWAALLRTVLPPAALPASLIGFASLHRTHLLPHDTVQAISLPAPSSTIPPNGPKSKLNSAVHTEKDLASQPGQSTPRGQITFSFAKPDMPPEGRTSNGLVVTLLNGVLTVEQTFDRQFVSTLIPAEGSGLEKKTITTKQVGVEVEIEMFVNAVQAAKEGRENKEENFGEPRGALWDLSVVEAMLKSDGKEINLESLIKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTZ6</accession>
    <name>A0ABR3BTZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103459</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614338.1">
        <property type="nucleotide sequence ID" value="XM_066757954.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990315"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="11">
        <location>
            <begin position="105"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="10">
        <location>
            <begin position="261"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0250151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="363" mass="41157" checksum="1A8ACEE57283E7F9" modified="2025-10-08" version="1">MSEQAGPSQITGDPQRRKSYSLRDEFHGATQTQKRHKVTDVSEIFQRPDAEEQKRLNKEYRALQSKADELKANLANATARDLAQALQKQALLFQNVKDTGIGTLDANLLRTNTENAMGLAKRFKIDGVTFDVDEFLIKMKGHLGLDRVELLDAEVNSDEEEEGAERQGRRGALGDWEKIGWMAARYYRRIPGVEFLYGPLQAEPKVRKVAQRRAKADIPLETRPIEVQNQTASAKSRDEFTANVKTVMKTLARLDPDGEGVNFFRLVVNPDDFGQTVENCFYLSFLINQGQAGIYVKKDGEVMARSTIHEEIGEGGDQAKNQAVLEMDMETWEIAKETFEITHSEIPHRDYAEIRIQSNSWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUA3</accession>
    <name>A0ABR3BUA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RraA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614712.1">
        <property type="nucleotide sequence ID" value="XM_066757243.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989559"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27341" checksum="BB1E9700B4F550CC" modified="2025-10-08" version="1">MTQRQTFDSLEELSTCEISDALIKLGVQTGGYLPELHLYSPSDGRKLKVVGPAFTVQMVAENVQREDEPPKSKEHFVDACPSGRVLVISAPFIRNAGCWGGLMSTAAKAKGLKGVVIRGGCRDLAEHRELGFPVYASYHTTLGQKSFVRPSLLSVPIDMSPHYYSSPSIASLYSPSFEYRIIVKPGDIIVCDEDGCVAVPPDLVERVVEKGKEGRDIDENVRKDLEKGKGVKESMAKWRGEEKRDGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUA7</accession>
    <name>A0ABR3BUA7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylinositol glycan, class F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_103330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614214.1">
        <property type="nucleotide sequence ID" value="XM_066757830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990186"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32298" checksum="BEDA16DFCC2FA237" modified="2025-10-08" version="1">MAPVLPLPEYFTLLLYLAILLIAAFISLPHSTSYFLSAPLAQSSSADRPEHAFLTPITSRPLITMAWDVIGVGMIMFWWGGKMKGWWEGKPDARKQEVVGESDMEERTSRTTKMFARFKEAGMATAGMTGIYYLFLFLLGAPLNSHFSHSLLLALHLSILTVWTPVYSLGIPSLYDQGIFARFRMTRLFCQFEPENPVERALVYPVIGTFVGAWIGAIPIALDWDRPWQSYPLTVAFASILGFIVGGFASWTHSVGEDLYEEVSAEGNAKENEKMGKKKKNKKKKSIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUJ9</accession>
    <name>A0ABR3BUJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613965.1">
        <property type="nucleotide sequence ID" value="XM_066757581.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989936"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0249778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="320" mass="36951" checksum="97654F90A3407CAD" modified="2025-10-08" version="1">MILLEPHNVIINDVLSDRFERPSRADIQFVDYDNVRFHLSTPSSKTQLLLSMGIQCWPDLVKYGAREHLQNEYQGYLLSEADTEPEYDVSLLIDLERSPESPEERVALISKIAHLKSTAMSSPFLAAFAEQASLQASYKEPAGAQQADLQPSEVKGDLKVVKYREEEAIFIQASHDRVTIIFSTVFKEETDRVYGRVFLQEFVDARRLHSLQNAPQVMYSNREPPLEIRHLPGLKNGEDWGYVTFVLFPRHFANPSQALATINRIQLFRDYLHYHIKCSKAYMHSRMRYRVAEFLKILNRAKPEIASEKKTASGRTFRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUN0</accession>
    <name>A0ABR3BUN0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102579</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614593.1">
        <property type="nucleotide sequence ID" value="XM_066757124.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989436"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="31"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="552" mass="60091" checksum="E2F66228FF0131FE" modified="2025-10-08" version="1">MPSVPGGAGVLSAPLSPERVEAPVTIKAYLLCVFASFGGIFFGFDSAYMNGVLGMNYFINMMTGLPIPGPDADQATKDAFTLPAWEKSLITSILSAGTFFGAIIAGDLADYFGRRITIVSGCVVFIVGCCLQTASSGLGLLVAGRLVSGFGVGFISAIIILYMSEIAPRKVRGAIVSGYQFCITIGLLIASCVCYGTQNRTDSGSYRIPIAVQFAWALVLGGGLMLLPESPRWYVKTGKVDEARKALSRVRGQPMDSEYIKDEIAEIIANHEYETELTPNVTYLSSWAACFSGGIRNPGSNLRRTLLGITMQMMQQWTGINFIFYFGTTFFTDLGTISNPFLMSLITTLVNVCSTPVSFWTIERFGRRPLLIYGALGMFICEFIVAIIGVAKPGDATVVKAQISFICIYIFFFASTWGPGAWVSIGEIFPLPIRSRGVGLSTASNWFWNCVIAVITPFLVGTDKANLGSKVFFLWGSTCILCFIYAYLFVWETKGLTLEQVDRMMEECTSPRHSPGWKPHTTFAAEAAHDKPVIEQQEKIGAATPTELLEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUR9</accession>
    <name>A0ABR3BUR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102863</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614867.1">
        <property type="nucleotide sequence ID" value="XM_066757398.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989719"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="252" mass="27892" checksum="B0BEA026595F3947" modified="2025-10-08" version="1">MSASQIISKRRKFVADGVFQAELNDFFTRELAEEGYAGCEVRVTHARTEIIIRATHTQEVLGDKGRRIRELKALIEKRFKFPENALELYAEKVQYRGLSATAQAESLRYKLLGGLAMRRACYGVLRFVMESGAKGCEVVVSGKLRAARAKSMKFTEGFMVHSGQPARDFIDYAVRHVLLRQGVLGIKVKIMKPSDPAGRQGPAKNLPDDVQITEPKAEGVIEIRSDHKNPPVQAIPPTAAPAPEAQAAEAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV48</accession>
    <name>A0ABR3BV48_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615000.1">
        <property type="nucleotide sequence ID" value="XM_066756223.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988527"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="201" mass="23644" checksum="514152BF932AA890" modified="2025-10-08" version="1">MGAYKYLQELYTKKQSDVLQFVSRVRCWEYRQLAVIHRASRPSRPDKARRLGYKAKQGYLIYRVRVRRGNRKKQAPKGATYGKPVRQGVNHLKSPRGLKATAEERVARRCGNLRVLNSYWVNQDGVYKYYEVILVDPSHKAIRRDARINWIANPVHKHREMRGLTAEGKKNRGLGKGSKHNHQPQKATWKKHNTLSLRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV59</accession>
    <name>A0ABR3BV59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I308_101646</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614977.1">
        <property type="nucleotide sequence ID" value="XM_066756200.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988504"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009805">
        <property type="entry name" value="PRK13289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045559543" description="nitric oxide dioxygenase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Globin" evidence="16">
        <location>
            <begin position="80"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="230"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAL0252257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="503" mass="55599" checksum="E54F0C0DAB73C818" modified="2025-10-08" version="1">MDAKKATIAVIALAAAVTAYKVMSTTQEKKNTEGVCPATGQKLAGSTGCPFSSGMPLPDPAHRCDPNSIQEEYKVPDVPPLTEAQKDIIKSTAPVLEKHGVTITTHFYKNMILAHPELKDVFSESAQKLGHQPAALAAAVYAYALNIHDLTPMIPVVERIAHKHTSLHITANQYGIVGKHLIQSIVDILGDAVTPEVADAWYNGYWNLAHIFINRERQLYDSAIEAGGWEGWRQFKVAKRVKESHEITSFYLKPVDDSKPLPKFKPGQYIGVQIDIPGLGHKQARQYSLSDAPNGEYFRISVKREDGVAVPTADNPEIPLHPGWTSNVLHKDYQEGSIINVASPYGDFYYAPSSSSPTAPLILLSAGVGQTPVMSMLNAQLVKNNEPDAPVKPITYITVARSPKVRAFKEHVKKLSDVHENVKSRIFYSRPTDDVVEGKDYDFKGRMDLDKVKEDLYLGDKTAEYYICGPSKFMLNARDKLESFGVDPSRIHYELFEAGNLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVN9</accession>
    <name>A0ABR3BVN9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615184.1">
        <property type="nucleotide sequence ID" value="XM_066756407.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988714"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="358" mass="39031" checksum="26B255EBADF127FB" modified="2025-10-08" version="1">MSHSPPPLQHPKPTHIAYPPPEPPHTPAQSTDSSPYSQPQRISQDGYLRYSSPPASEPLASSSGFSSYAPPLAQGQQSAQPRQPYGQGGTPGVQGVHGYAAPGYAWPGMNDATAQMGMQFGKSAVAAGQEYVEKNFTRYLPLQLIKVSFSVTNTYVLKKLRLILFPWRHKPWSRQSRRSTDNGTVEGWQAPRDDINAPDLYIPTMALVTYTLLCALASGLQSRFHPEVLGLSLSKALAVVITEFCAIKLGCYLLDVRNSGASGVELVGYGGYKFVGIIATIVVSLLGLGKMITLGVFIYTFAANAFFLLRSLKYVLLPDASVSSSVTTLSHSQRSRRVQFLFFVAVAQVLWMGWLSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVP2</accession>
    <name>A0ABR3BVP2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615178.1">
        <property type="nucleotide sequence ID" value="XM_066756401.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988708"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="272" mass="30368" checksum="E27A77346AA06EEB" modified="2025-10-08" version="1">MSSSSPTPSSSSQPFPSQFAGDQQDRPGSFYRNLFYILIGILCGFSIFSFFTLMRARRRRRAIINEALRLGVMVPGVPGYLPLQDREALLWMKSDGNQSPDWWEIEKLKDPYHPPPLTEDGDSNGPMDQQNSVAQPTGDLPQWQENQEYSSSSHNFDSLQPLATIPPVATEASTQPMPISNLKYFPNHLAYRPSAFMPPPGRFMDLNSENMTEKLGQLKGNAVEVVVVIRMPVPSSTRTNTDDEGVEVFKEWGGIELGVTKLQVASEPHEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWB4</accession>
    <name>A0ABR3BWB4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615398.1">
        <property type="nucleotide sequence ID" value="XM_066756621.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988928"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="584" mass="64743" checksum="7D0A8E1353070E90" modified="2025-10-08" version="1">MPRSPSPPPRLPRRPFIEDSPQRFRDRDPRDDGRYRGEPSRYRSPAGFDRDRRDPRDRDWRDRDVERDYDRGSRFGGRQSWYARDRDAERMRERDDRDRIRSPLPARPGFTPIDREERPREPREGSTKTRSEGTPEEGQITSPVVAAPTISGLPPRPRSPPRSPPRRRSRSPPPFRRFERDSWRDRERDRERDRFYRRRSPSPYSPIRRRRRSPSVSSASTPSRSSRFSPIKRGISPTERSRRTRSPMSEKPQRLTSPEPRSPEEPSRPLSRASVSGPTRPQTPTSHPPTLSTPQPPVPSLAHAQPSSTPLVPTFPKRPPPTGPRSERLGLAPPSGPRALAHLYGGRPAAPRVPYATPIAGLSGANPTPTATVKNDFQESTTPETPSATLQAHAPPTGPGSGRLSWSERKNVLSQPHPTPTSEQISGVNPYAPLPSRNGQAAHRQGGSSPPVPAPHSSSSVSTIPLPPVLTPAAEEPTNVEESVVAEEELAEMKAKEEKARILAELPPVLIGFGTATWETELASHIHHYTSLVQNTLRLQAAQRLAAASLADAEAERIAAIERSKICDEQLMSGTLGGGIIGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWE3</accession>
    <name>A0ABR3BWE3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615186.1">
        <property type="nucleotide sequence ID" value="XM_066756409.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988716"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00677">
        <property type="entry name" value="S15_NS1_EPRS_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_uS15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="269" mass="30034" checksum="76587287DD98737C" modified="2025-10-08" version="1">MSPQNLLYTSFRATLAPLAGPSTPRAFSSSQRSLVSTRKLVAKRRKAANLALQASRVRKPDSIDPVLGRVQYKGEAPTNPWEGCRLQRVLLDYNAIAYSMPPDYTAGEQPRYLLPGVSKEDAELLFNAVPHASTEIRYASGQGSEKTEQEQARQSEMMMRILDLRNASKDAINILNRQRVIDEFGAGVDSGSSAVQAALLTAKIHNLLSHIEGNPRDTSNKRALRLLVQERARHLKYWKRKQGEEAYDKLLTDLGLQREAVEGELFIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWI6</accession>
    <name>A0ABR3BWI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450 monooxygenase pc-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615468.1">
        <property type="nucleotide sequence ID" value="XM_066756691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988998"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="63212" checksum="8B8FD595E3B0BF02" modified="2025-10-08" version="1">MKRGRFLLLALFKTLILPPLIAALFTHHFPSLSLSLTALIYLISFPALYVFRSYVSLVTSSRKASALGAVDIPRVKGAWPLNIDVLLNWAKSGTEEEVGRMMVLMGRQYGETYNTRVLGEDQIISSDPKVIKHVLIDDFDNFVKGQKFKDRAQDFLGDGIFNSDGDGWKFHRSLMRPFFHPTLPSYGKAFDMQACIGQLALELAIMWLCGEDMSADASNVERTEEWGKAKREIGWAMTEAQKVVGKRVKIGTVWPLFEIIHDPLERPMKVIRAFFRPIISQALNRKRQRCKLDDQEDAYMIDRLVEATDDIKLVEDQLINVLLASRDTLASLLTFSVYAIALHPHIAARLKNEIFSVACRESEVTKDTIRQLRYSRAFINEVLRLFPPVPLNIRRTLRPSLLPTTNHLAYMPANTSIILATILMQRDPAVWGGDALVFNPDRWLGGGLGKERESFASWNLGPRMCLGQQFALAITHTFLVYFFRHIAHVGTLAGQNTTIQLALDAQPPETVLPKRWMTSEGSDGRTRGGRDRVWIVADVVLAVKGGLWVRFGAENTEWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWM7</accession>
    <name>A0ABR3BWM7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615502.1">
        <property type="nucleotide sequence ID" value="XM_066756725.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989032"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="169"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="721" mass="77367" checksum="7046D38FB7059F68" modified="2025-10-08" version="1">MDNRQHPPQQQPLPPVFSMTIAMPGPPPSRPSPLPDGSDAQQAPGSDQQPAQESTIYWTFHIGPGSAHDNQPSNEHSATTGPDGRGGEPRGPAEGGGDASNNAPPTWLFPPFFQFFMPRREPQPNPAKAVELLRSLPTVRKRLLHRVNNIVAAQDVDSYEDDDDRGWKCGICLEGIPKEKFEKGEDKEAVGGAKTEGEKEGDKGTGVKALPCNHLFHADCLEPWFTTHHTCPTCRLDLDPLQTLNVPPHPGPAHPNSLRPLRTGAGRPTSNVHPYSRDQSRNGERNQTGTGDQVSADRSGSVDNSGSNTPQGREQRSSLTPHLFIFAGPHHPQESQQEHSPEATNDTAATLDGPTPPPAEPSSTNLPTGGEASATPGENSGPSASHAPLFDPAEILGAIFGGRPSASPMPMHRHSPPLPSSPRENPTQRSNVPPSDNTEPTSTSPSGDTEAQGGSSVGSQSAPEQPAQPPPSGRPQPERRAHIQIIQEALGQLPFIFNSQNNVLPLPTTFPFPGMTPTGERPGAERPVTPNGVNDMTGGSTAGAPASGDAAAASDTRQPHTQTSAKQPFVPQSLESWIEEKEKSLGWRCDAPECVYGPSVSEEDDDTDAYPPTADDELGEGRRDKEMVSIFSAVQPPLSSAEAIEARETDHSFTLLACTHRWHRRCLEISERSARRMSKDDGDGRVWVRCGRCRKSGWITPVAESTESGVGRKRKEAEMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWY7</accession>
    <name>A0ABR3BWY7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein STU1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615623.1">
        <property type="nucleotide sequence ID" value="XM_066756846.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989154"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="311"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="765"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="645"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="805"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="822"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="854"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1248" mass="136338" checksum="1DFDE2CB278DEB29" modified="2025-10-08" version="1">MPKTLTESEVEATLVKLKAADPDKKVDIIQFFGLQLEDVEELPTNIIDPFLLILPPLIRTPHSLLLSSVLSSFLPYFLPLIPKHPTTHLRLALIQVLPALLEKLNDAKERIHSAAGNAIVILGELSWEAEPPVPTSNLNSSGSLKPGSLSSSTNTKSKPHETLPHLWERHLKDVLQGKAWRSKVEGMKVLARVRNKEGAKMGLKSWLGILVDLLEDGDGNVRDQARETVVELLSPPSTPSAARSDFKRLLVARNVRKTIADDIITRILSGEPADRSAPAVVNSEAGKEEGASRSGAATPALSQTDDVDIVYIASPHDLEREFHSMLSFFEGKETEENWAPRERSILRIRGMMKGQAHVKYQAAFIAGLKDGIVEGLSKTVLSLRTTVAQQSCYLLKELPEGLGAAFDNFVEYLLPILGKMSGFTKKLIADRSQTAVTSIITHTTIHPRIFINHIASGIQEKNVQTRAYSVNHLKTFLIVHCHAKHQIEATPGLSDTLDGAVRKALADVNPGVREVARQAFWRYHEVWRSKAEVLMNSLDGQARKQLEKANPRLTASPVASYPSSSSTDAPSSANTKFQSKKVDLKTMLAERRRAVKEAGKRAQETNAGSPRVVSNPVPASSGVQHASTTGLPRSSSAVGIESHVHASSPSPVRSPTLSSSAIRTRFSPSPKPIQFPIQKKTEVDSPLRSRSTSLTPDLGRSPRKSPSPSSRPGLESDESPLRQVSIYPAAGGRYSVGEGRRAVSEFAEVARNGGELEVEGLMLSEGQGGGLEGNTNQEQPPAVQEEVDQDEQSQQPGSEFELEQPVSQQGDIFPTSSSGHVPSTPARSTATPTATPLPSSRNENVNGEKVVGSKVNSEAFQTPLNPRTNALRGGGVIRTPAWKDSPRPEAVTPQMMQKLKERRHERSWWVKRQELLEKASPLKPLTPSPSSAILSDIEALELGAPTFRNLQKIALFCSSHPVRPQPVVEEGEEERRAFEEEKSVWTGLFDRVMDGVIDLLRPDKDKELLEQGLVVLWEIVQHQWPLVDDTQRLCHGLFRLRESHDAVILESTNALTSLLVQISDPMLLLFNLRSSLDRFLTNHPVPLSSFADSPDPVTSAFSQLSVSSSKESPEKMTRNSGYLLGLTSIGMCVLRLSAPVVVSEGPKLGQIVMEAIKDSSSIIRQAAHSLLLAIQCVIHDSRKTLAFVPALSQGQKDLAVYYMAQNGVLEQIGLHKKAANEGETGGEEKRDNMAGELAGLMSRGVIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX24</accession>
    <name>A0ABR3BX24_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615664.1">
        <property type="nucleotide sequence ID" value="XM_066756887.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989195"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="1">
        <location>
            <begin position="60"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="259" mass="28767" checksum="62A85A0B95E7000A" modified="2025-10-08" version="1">MFGQKQYDQAQFNDLLSQVEISKHDLNALVLDYLLIEGFSDAAVEFARETGLPADVDHAQVAERMEIRQAVEDGRVEEAVRRVNELDPEILDGNAPLLFHLHLLRLIELIRTEDLDTALAFATEELAPRGAQNPEFLADLEKTMALLAFPDLAKFADDSPAADKPTLAPEALTLFEEPAFEPIIALMKRSQRVKVAKELNAAILENQGYGMETKLSGLVRLMAWGEEKLVEGSDVVIPEEEQRKGRAWADAVLSGEVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX79</accession>
    <name>A0ABR3BX79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615200.1">
        <property type="nucleotide sequence ID" value="XM_066756423.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988730"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="908"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1555"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1338"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1387"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1555"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1565"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1579"/>
            <end position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1675" mass="182229" checksum="BCD96BCD28C00A19" modified="2025-10-08" version="1">MDRLFRKKSSRTSGKRLNSSKGKSKQSAALSESTTNDGSKDVYGEKRVPGVAPSLDVEIRNSLILPSLSQRFSVLLPPLATAPEDSLRTLLASQRARMHGPALTEEEEELLFAELKATEGNEWDLMPPKSNCDSDAIRTPNSKANITPNTFSPVIETSASSLSISVSDDGQSSPLHSDTIQLISSPSPMSNSFSSFKTFGIASSPGQPTLGSLKSKDLESGMVNSMGLRENAYLRRLPEQSGTNGLKYKSGKLRGKKEQNDKGDMPTVTLMGTVTGRDINPQPRIPAGSMESRSTVASLSFVDGPHSHGTPINNTLRPDLESPESSNIADRPRQTYRRSLLSGLTPAQVKRISMALEEIGGELKRGGNNMENNMSKGRTASDEEEVLASGESRKDVSGDQDEMGEERPRRPSDVFSEGSRSATSSVFPFKASPTNSTFTGRSAHTLTNTDPASPSRLPSSPRSLNLRAVVDEDVPPVPEPILTPTRLQPVKVKGTPSNNSAASTPTPSLVLHNPAYIPGQPRPIRPVHHGEVSLSSRAATSNGQLCFDILPNPRSATPDSQSPLNTLRSSTAYSDATQSTSTSPSPLLHYPIFPAKATALSRSYSVNQASGPTHRNSNQSSITHRRGGSIALGEIESGRGLNHPSEVRSVLQRGIAEEDEQVEKEDTRSRERLKENQNDRRPTLELGDAISQHNLEASSYDSEKIIDEKESFQSGRKSQVRDVVERVMFSQDALRTDDTTPEGTNSSSAIPLQHLSSDSIDSVFDLDQDVSQWMVIFDDQDFVPVDSKIDISDWQERPELVLEKITGLGAEELVLLQEELVAKARREREAMGLGFSPLISETPTIPMQYCSSKQRQSSLDMEGSPMVDVRTPNPITMEGIFPITSAMEESWSMASQIADSVPCAPQLSTLDTSLRPAPAPPSHEAPSGETFSSAVSMHGNVIDSTTVSPETEKENDFRTRIAAATAALNRNHSIQGARLERKNTKRGAAMVISSPKLLSSTAKVPTVPLTPPDHPVAADSILEKSLEKTSGSGSKMSQRWKKLMKKGPSISSSEALNPVEPISGADSGLWNPNSVPHPAPVPLLQRSNSQSVSRTLEAPIKLRQGIPLSSAPPDLNSFQFPSRTDQREASKAEYKNCPPKISHVPVSQQAQSPSEDTAVLNFLQAGRKLGLTEDQLKDVLIEKEMSSGSDAIRSKDSALPSAKPILKSSPSSSARQQSPGPIWQTQRQSTSIKQKKEGLFRSLSKKAKELPNRLRTPELDQKEAMTPGFVPDPLHDKVVLRRTMIFPDGLFVVPSAQMASDVTPGSPNSSNVGRRPSQRKPSIRRKPLNLSKEDRELVSNSPPAHQMGFSFNASPSQTPESIAHESHGFSFRYRNPALPTNDSIKPRGLTSATLSRRSLSGMSERSSTAGSLIDMYGDDQNGGEEMLLKKICEYADGQVIWSVVDALRTSVTGSVDEDDYTFDRRLSQSSSVYSTNKESVFGEKCDLFAGTKSMNGSSGANVGGYNLRHLPGRKSVIKPRPPTDVYFTSSRDVADLIDHLSRDLESSRGRIDIISSHDSSVDSDGPFHHTPFDMRQLRTPGSPSGNSQFEDAPSPASPPQKILFAQHSHPFGSKARHYPGEISPGRETSLKYHVGHPVDQPSNSTSFADGESKHLEYRLRELMDRMRNANPDERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXB3</accession>
    <name>A0ABR3BXB3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102954</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614925.1">
        <property type="nucleotide sequence ID" value="XM_066757456.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989810"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="548" mass="59866" checksum="0193079ED3E51E75" modified="2025-10-08" version="1">MSVDQINPGQAVYAQDENGRPFIIVREQGKKVRTHGLEAIRSHILAARSVTNIIKTSLGPRGLDKILISPDGEITVTNDGATILGQMEVEHQIAKLLVEVSKSQDDEIGDGTTGVVVLAGALLSSALSLLDRGIHPIRIADGYEKACEIAVAELDRVADTIEFSKDDVSNLMKTAKTSLGSKIVSIAHDKFAAIAIDAVLSVADLERRDVDFELIKVDGKVGGSLEDTSLVKGVVIDKDMSHPQMPSVVRDAKIAILTCPFEPPRPKTKHKLDIESVEEYKKLREYEKEKFLDMIKRVKDTGANLVICQWGFDDEANHLLMQNELPAVRWVGGPEIELIAIATNGRIVPRFEDLTADKLGHAGIVRELTFGTTRDKMLVIEECANSRAVTVFVRGSNKMIIDEAKRALHDAICVVRNLVRDNRVVYGGGAAEICASVAVSKRADEIPTIEQYAMRAFASALDAIPLALAENSGLSPIDTLADVKSRQVTEGNPRLGIDCLGRGENDMKKQHVYDPLISKRQQFLLATQVVRMILRVDDVIDASAFGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXT8</accession>
    <name>A0ABR3BXT8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chlorophyll synthesis pathway protein BchC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615071.1">
        <property type="nucleotide sequence ID" value="XM_066756294.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988598"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08234">
        <property type="entry name" value="threonine_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="174"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="349" mass="38068" checksum="5710AC790436BA59" modified="2025-10-08" version="1">MVAKEMNALLYSEPRKFEIKKVPVPEIGPEEILLKVDICGVCGTDQHIHEGEFIAKFPLIPGHEAVGRIVAMGDKVKGFDIGDRIAADVGETCGYCHYCRKGTELFCENFAPAGVARDGGFADFIKYHFAKCYKIKNLTDEEATLLEPASCAIHGMDVLKMPFGARVLLIGAGPTGLILAQLMKMGGASHITIAANAGIKMDIARKVEAADEYIDLDRSNPGPQWAKLKEDNPYGFDVVAEATGVESLVNDAINYVTRGGTLLVYGVYEDKARLPGWSPTDIFVNEKRIIGSFSQTYCFPRAIDLLDSGKIKTTGMVTDVFPLSDYQGALDKMASRKALKIAIKPEHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BY66</accession>
    <name>A0ABR3BY66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615485.1">
        <property type="nucleotide sequence ID" value="XM_066756708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989015"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="256"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="738"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="877" mass="94267" checksum="644B5C991B84E04E" modified="2025-10-08" version="1">MPSRWIPSGFTTPSAPSSRASSPTRTGPAPRSANMLSSRRRDGTVDSGELGDYFSAQPSPVYDASAPTSPSLWSGPAAPSAMSTPGGSSGHTLEIVLDSDQLVLRGQGGDMNPAYLSGRVELNLLEATNIKEIMMSLTGKAKVQFSDGSGTSSKHRHYSHLITSHDWSFLQGDRGHSHTLKAGRHTFPFTHTLDGNLPSSLRTYSGDALIVYKLRAVVVRSGFASNFSATKEFKLSRMFTPEALEFNQTLEIENTWPGKVMYSLTLPYKAYAAGDEIPVNIKFMPLAKGVRVTTVVSVLKEYTLVHTKHSSHPDTRVDSCVKHEIRRGQAEEIAREPIRPPQHWVDAHGHSSRSSANTSRHPSPSQTPAVNSRARLPTTTWGARPRDSYFPSQTSDAPEQAQAGPSSSRDSASITESTETDIEVGDEEVDTFFNVPIPAWVTPSHAIHPVFVTHKIKWACSIANPDGHVSELRCALPILILDHSLLNEARAAGASTRGLLFGNTQPEEPQVDLPSYSNHVYDRVAIADSSTPAGWISRSINPTPLHSPHDDTPPRSRAPSRPGSPTRGRSGDSTPEVPPRRQLSQFVDSELLLSLGALRTHSTDTSPHSTPPDSRAPSRPLSRRNSRSNLSSRVSSRPGSRAGSRASSPERGSQPSSTSGSYVEEAHLRPGYERHRSSGLHGLFHLPLKPMRPLSHLSGSHISRPILRNGNQSNVNLPAADDVIPRNSSVPGSLNSTGASNSGMQSSASSQNHVSFASHAITFEPDRSSTRFEVGAPDTPSETEDDIDPLMQVPSYDIASRGFLGGGVVPIDTRLPTYDASEMSMHRTRSGTDLGSSGSLVRPRSDSALVQLGAQAAAEAEERANDDADDTGAPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYM1</accession>
    <name>A0ABR3BYM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615717.1">
        <property type="nucleotide sequence ID" value="XM_066755431.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987726"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="6">
        <location>
            <begin position="308"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0253496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="744" mass="81027" checksum="1D70B3884D848101" modified="2025-10-08" version="1">MSLEISGSLARAYVNIHRHAVGGRNFENYSEDPYLSGVMASGYIQGLQGAGITSVTKHFICNDSETDRRTVDVIVGEQALREIYLKPFQIAFERAGPRGIMTSYNKANYLGNDPQFIQRLLESVVRGEWGVEDLTVMSDWWGTYSVGRAIMAGMDLEMPDSFHRGNGKLLAAAQDDESLAKAVFDRARNVLRMIKRAGGYSLEPERPEIAEDIPETRQLIREAGAEGMTLLKNTGVLPLSPKTKAVVAGTYATVALAHGGGSASLDAHRKITPAEGLREAMDEVVVVPGPVPYLYLPLPQSDVFSSSGGAGTCKVDFYNPGGNLVDSRTLTTTFLTALDRYPKNLVTGWTAKISSKLLPKTTGTHALTMASPSSAKLSINGQYVCETDPDPARRDDFMQLAFHKCCVNTTYTFEAGKEYDVVIDYVSTEELFYSTACALNGIRFGYLEYIDDDAAIQSAVKVAEEVGTVVVCVGHGSDYETEGFDRDDISLLGKQNAFVQALADSSAKVIVVVFAGSPIAMPWLDAVEAVVYGWFPGQELGHSLADILTGKINPSGRLPVTFPKVIEDSPAFGNFPGVNEIIKYEEGVFVGYRHYSSRQIPTLYPFGFGLSYTNFKVTDMALRGAESFGPGKKIEISVKITNTGSTAGRHTVLLFAQPPAAEDRPTLSLVDFVKSSELKPQESQTLTMTIGGEALSVWEGSEAGSWVVKEGRYWLQIRDSVEARPMPSAELRIGQGWKWHGLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYP9</accession>
    <name>A0ABR3BYP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615744.1">
        <property type="nucleotide sequence ID" value="XM_066755458.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987753"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="130"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="689"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0253523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="888" mass="97894" checksum="A3B78B3142B0817B" modified="2025-10-08" version="1">MELPFPSLLSQQASGMPTSDLPLQHASLHSLPSPRNSSHFSRESTSQTLPSIVPPGVSPSYALSPSSKALAFPQANSNSKSTSDQAGPSKMKSSPDESSQLEKPTKKRRKKGSEADGDEKKKTRPKTGRACDACRSRKIRCDIQTDQSPGNNFGQTVCAHCRANDLECTFFLPITETRFKKKTIQPDINPELRHSPAVAQRRTSPSHSPNYENMAGEREREGPGIGRIEGPTSISFLLHTSLPANQSEAYDLRHHNSWEVLEDGNGFIRVNAPPTATGYADADPQDPTKAHNRLNKPVLSAQTMSLLVNAYFNEVAPILPIISRAEFASKSNPSPLMLYSICGLGATRRQFPKEIFTGVRGVINGILRSNDILSDARIENVQALLLLAQVGDLHAQPSAPTASASLIRTGAAIRMAQDLGLHRELSHRTESTQDLMFIELRRRIWSACVIMDRWYGAALGIPLTVDILDCDVLLPASYEIIPDVEPSKWPIELSYLGLTEHLKLSILMGRVLKTVYSPTGLKNTTDMILGQLVSDLNQWFENIPESLKFKGNSSSSVEGLLFMAFVAVQFLFWRVFMRMDYQCPQHLTFTLDISKWTQLVTWSRQALEWLDSNDSVLDTVFIYPYAATSCSLIQYHTWARRGDMEALDTLKKVKGTAMRWEGIAQPDQMSIRRKTCETMTLLYEAALKTNPSGNDKPQPSGNPTAGVQLRKEPARLIFVKDPSRPGGGFYVADSEKERASFGLGLRKGDIVLASELSSNEAKASQSTAAQPFESPSLPQGAQIMRAQARARSAQQPFMQTHTDDLGHIIGVDGVLQNMQNVNPQLGSGELGQAMDFGYQVTHAAGDTSSVLDPSFLDSLPLSTFDWDSWSTYFDKVLPSASNSFETMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYW8</accession>
    <name>A0ABR3BYW8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615809.1">
        <property type="nucleotide sequence ID" value="XM_066755523.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987820"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="277" mass="30154" checksum="50F6B1D987110492" modified="2025-10-08" version="1">MPRSSSPSLSSSRRPSYPSSFPSSPFPTPPFERTVTCHRLLSSKTYVRTSPYPSPSPSPPPRTDAIRPGPPKRTHSFCATDPTSTYALASTSSATHLSPDKRFIIAPPLERTLSSLGTVGDWTSPRQQMAKPPGIYDREPENLETPKKNRDPPSSEGPVLREVKRNPRSVPSSPSPPIFISSPPVIPAILVHPTTTPPRPTLSIIQTNTPSNSSSRSSSYTLNTPITPGGMLFGVIEETEEDLDMTPSKSKSDRKFMEIERSVKGVTSEINELSLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYX9</accession>
    <name>A0ABR3BYX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615431.1">
        <property type="nucleotide sequence ID" value="XM_066756654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988961"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="104" mass="11519" checksum="4F8803A1449749FD" modified="2025-10-08" version="1">MVKAIESYDEWKTLISGSDVVVVDYWATWCGPCKMISPHFAKLEGKFPNVKFVKVDVEEQEEIAKEAQIKAMPTFIAYKDGQVIETVTGAVPAKINALLDKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYZ3</accession>
    <name>A0ABR3BYZ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_100987</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615834.1">
        <property type="nucleotide sequence ID" value="XM_066755548.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987845"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="159"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0253613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="527" mass="57960" checksum="F92376337F20E2DC" modified="2025-10-08" version="1">MSTEQPVPTEIPAALLPLLGALSSLLYTLQSLFHKVPGSPIILRYIKSSYQNDPWRSLLEVLLVAFALRTLLKGRTRGDEEGKNFIKLTEKEIDELVDDFQPQPLIDEPAEIDSFTLESVPVIHGPNGARVKLSPNGKTVLNMAIPDWVGFVEDDKMKEVAIDTLKEYGVGTCGPSGFYGTIDVHQQFETRVAEFLGTESAIIYSQSFSLISSVIPAFAKRGDIIVADRGVNFAIHKGLQLSRCQIKWYAHGDMKDLERVLQNVDKERKRKGAKLTKMFIVAEGIFENDGMMLDLPKVIELKKKYKYRLILDESQSFGMVGQHGKGITEYYGIPAAEVDILLGSMASGLATGGGFCAGSKVVCVHQRINSSASVFSASLPSMLATTATHAVNVLASQPQLLSALQTNIAIFRQQLARLEPSEEGDKLNKDAIISIPSHPCSALIHIFLLNPPPTMEEEERLLQDVVDEALNSHGVLVTRARRLRGQEIFEPEPSLKICISAVWSKKEVEKAGQGLRSALVKVVGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZP8</accession>
    <name>A0ABR3BZP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616078.1">
        <property type="nucleotide sequence ID" value="XM_066755792.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988093"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="115"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0253857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="487" mass="51837" checksum="C610A4C01DBC2D94" modified="2025-10-08" version="1">MPAHEPSTLAKAHPDHPTLSELVSDRPDSTTTTPLGHDIASPQQTTTPTSMSDVDSSSSSPKAALRPGGFSEGPNARSKSVTVASGEDTFGALNCHPAPGSSTVVDGNLPAESFRVGVSEDRNRRCRRTMEDAHSFVYDFAGVKGQGYFAVFDGHAGKHAAEWCGQNFHEYLLDGLLTEPDTPIPDLMNKTFHLVDKRLSHLAHAGGTSSGCTAVTAFLRIEEMDDSSHKGFTNPGLQARGLAEGKGEDELESQTSLQPSSRRSSMGGGTGGQMGGASTPGVNGRTGSLARRLSSKKIRDFVKGLTSGSDKNDDDVIAEDEGVVSAADGTKVEAIEPQSEKGIRRVLYTANVGDARAVLCRGGKAVRLTYDHKGSDAQEAKRITDAGGFVMNNRVNGILAVTRSLGDASMKEFVVGAPYTTETTLDEQDEFLIVACDGLWDVCSDQEAVEIVHLITDPQEASKRLLDHAMSNFSTDNLSVMVIRFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZQ3</accession>
    <name>A0ABR3BZQ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101029</name>
        <name evidence="2" type="ORF">I308_101031</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615875.1">
        <property type="nucleotide sequence ID" value="XM_066755589.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987887"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0253654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="181" mass="20561" checksum="029ABE50E320D559" modified="2025-10-08" version="1">MALLFSRKVLFAGIFTFSFFAILTHLGISGSGKIHPGLTRFGLLPSSWAAKRSPYVRADEYPETEYVLGVAGFNYFRNLYFCNGTFLALTTNPSSFPEQGVNYIFSGLMEVDDPHRQHFAAEEDRFAIMTPKEAMDRGLLQPAAIRKEGITMFFNDVREGKHSSFLNHYYHFSTCFVLRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZV4</accession>
    <name>A0ABR3BZV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_101090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615935.1">
        <property type="nucleotide sequence ID" value="XM_066755649.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987948"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="13">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0253714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="253" mass="27172" checksum="FB33399E0B5F9B37" modified="2025-10-08" version="1">MAPSFVHEHVRSHAAPLARPHVTLTWAQSLDSKIAGVGGKRVILSGAESMLMTHHLRAIHDSILIGVHTLVLDDPRLQTNLLPPTHASPPPQPLILDPSLRFPLTSRILNEWNTKPALRGQTLKQPWILCGSNVSSERINEVEQAGARVVPVPLDSNGRIPPSSLPSILTSLGLRSVMIEGGSRVLSSFLHTLKRDDGSKLVDTVVVTVAPTFIGEGVGVVPEGEDKGLPALQTVHTETMGKDSVMVCTVDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZW2</accession>
    <name>A0ABR3BZW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615524.1">
        <property type="nucleotide sequence ID" value="XM_066756747.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989054"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="568"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="645"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="774"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="973"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="720"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="779"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1037"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1171" mass="130546" checksum="3748185D17787CAE" modified="2025-10-08" version="1">MSKEKQRELPKHKEKERSLQEVGEVGSATISLRVGAVEDLEEDDDDDGEYSTQLPQTHPSSLPQSQSYPTRRLSTFTTHQNKSRRERSNSLQTPTRPISLDRSFYLPHYSLDKEYSLPRKEKGKDKDGRTPKLELGLGDDFNTSFGEAMRLGNEGKELPLPKEALMMLSQAKEQIGSATKTKQGRKGSMGMGLFKESHAAAKVDLKRRPEEEAIEEEEDDHSGQTSSVKTRSRAETRSSRSTLASEPTIAGPSITPASPRPICGAGQSSDHDGISPTEHSPTATSAGLVSPQQHFDDLEEQFDEDDESWTTTSTESFTSEPEEEDRHWMSEGDYGSEEREEEERMTVPLQPFSHAVGGHSSIYKFTRRAVCKPLVSHENLFYEEVERLAPALLAFIPRYLGVMVVNYRRQRAPQEGGTTPLDSPCAASPYPSHPSTPADAPRSDNQRPMLQQALTGATNQSHTSNYSREDVEIPEVALDFNRHVVPDWLFNWEEKGKGRSGRPWETSEEEGPRRAMRPSSARSQEFMRYGSGSPGSSWQSSFGMSPNLRAPALPSPTLSKAIPEHQYAEPFTPAPSPSTSLQHRQGHLHHTASSPVLPYRSQFNNSSTDCHPGYSSPYLFGGTGSTTVNTKLKDHVFATILKKLKRRGVGHKQDDEADDEGDDCSYSVSSRRRGRRQHSGGGSMDLREPSEADEGIRRTRSSGVLTELRNKSTRAQTGRETARQVREHSAERGMFDMEVEDEPPLEIKRKVKVPLGNGLHPMTAVRADSHSTYLAEDQPSFGPSTSSFAPSSAPSSVTESGRPGQSSSGDPHTVPNSPPVYPDDNPRQELFIFMEDLTGRLKHPCVLDLKMGTRQYGYDATPLKKRSQRKKCDATTSRTLGVRMCGMQVWNNDTQSFVSQNKYVGREIKTPEFTNVIRSYLSDGDHLLIDHIPVIIQKLHDLASIIHQLDGFRFYGCSLLFIYDGDKDTQDTYSRQMNGGKPLDALEEEDEGETAEQVPVQDGKEAWVDSNRQHERSSEKDKVRKSGRSRSLEKSARHSSRSRSRGRSPNQSTNTHQHRKLRGEVNIRVVDFAHTTTGRDFVPFPTDHVDPPNLGKGYDTQFDEATGMVMARFPPKHPGKPDMGFLFGLKSICESLEEIWGAEKGGEEELVAKRNADIFDLVFANGADLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C006</accession>
    <name>A0ABR3C006_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616133.1">
        <property type="nucleotide sequence ID" value="XM_066755847.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988148"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0253912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="452" mass="48785" checksum="CAC2699A3F94F68D" modified="2025-10-08" version="1">MLLDTGVVDDPKKTGFYAGLIESMFAVAELLTVFQWGAASDRWGRKPVLLIGCAGAALSSVLFGFATTFPTMVLTRMINGLANGNVAVLKSVIGELCDETNQSIAFTFFPLSMAIGTILASAIGGYFPRITDRFPKLGQTIPIFDRYPYLLPCLVAAVFPLISGLVAWIWMEETLPPKTRDIQVEGQSQSRSQVRHAHPHTTVHYSSTDEGDTRMEGATDHHNTWTPPEHIDDQEDDAPVSFRDLLTPDINALMTSFGLLQLQGISFLGLLPLFCFTPVPSGGLSFPSGKIGLAMSIRGVSTIAVQLFAFPWLSKRIGTVKLYKVLVILFIPAFVLLPLCNVMARVGRDVGVWIGLSGSMGLYAAGNMAFACNLIMVNDAAPNRRSLGAINGWSQAVSSLMRAIGPGTSSALFALSVDKHVLNGQLIWIVISALSVVSALAALMLKNDHRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C066</accession>
    <name>A0ABR3C066_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101351</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616193.1">
        <property type="nucleotide sequence ID" value="XM_066755907.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988209"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13481">
        <property type="entry name" value="AAA_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="7">
        <location>
            <begin position="95"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0253972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="391" mass="42504" checksum="3D694FD0A39B1C3E" modified="2025-10-08" version="1">MPHLPTPLSALPLQRNLRIALTNAGYTTVEDLTKISPEDLSTELGINILQAEHTIQQAKQWLSNAPPDGPPSALSQHAQAHVQSSTAADLLSTSALPHFSTFSSSLDALINQFNSSTDVLPLSKRGEEFNHSGSIVPGMSIEISGPPGSGKSSIALAIAMSARLSSGNFADSVRPHDQSEKGEVLLIDTEGSMTSERLFKAAHHVHGDTNTLKSFLKGFHLVRIFSQAQMIAFIYSLSDWLESHPTVNLVVIDTLSFHLRQPGLDLAARRKIMELCKQTINHATALRRCAVVVCNQLATKLFTAESKPASFETSDRAVLMPQLGDWWTTNKTLRLVVFRGGSGDELRYVYASMSGSNKNIPWAAFDISKDGLPCDVPELTYQSCSQAHMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0P6</accession>
    <name>A0ABR3C0P6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616421.1">
        <property type="nucleotide sequence ID" value="XM_066756135.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988438"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="183"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0254200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="710" mass="78355" checksum="7DE1D4457DA0BE04" modified="2025-10-08" version="1">MALFQPSSYPPPSASPFGRLNLPHHTSSHHQRNDSNGSSYHPNNRPVSEGWLPELPVSQSRAYVSPDPSPRDEDAFLPHWGHHHPNVNQHAQSHSQSHQPRLPIPVLVAYSAPPTLPKMQFPHRPGLLASSDMPTGSGSVGDGRRHNGMGERDMTPEMDPFYNPTMPPPEQSSKKKKKKAEGKQPTFLTKLYSLLSQPEYSHIIRWDEAGESVFIENPEELADKILPVVYRQSRFASFSRQLNIYGFNRKLSLRNVVKGICDPDASSWSHSFLRRDSTKEQILSFKRRVPPRPSQARKRLMSIGLGVGIDTSYARTSNGDDQVSPTSSEHSLDWQSPPDPYQHHLLPDVDEESPFVFPTRHYFSLAGYGSVGYEGWKQNGAAAGSVQCVASQGEEEFSPTTIHFDYGTPPGRDRLNEFMASSQVRHGGSPKGLATNNPPSSHPFNHHTQQQQQVKPSLPVPCQPLLPFSLLGQKLPADLIPQSAPANTGSFPIPIRVTQQHVRTRSVQGEPPSAMLFSPFDGELREVPEPAGFSQNLNGTESHGHQPGTMDPPVTPAAPTYDPSDPSTRARRGFIDFNTAGFSDPLPFNPMPTYARLATWPHSLPTDMDPLHQQQTASPSELMGQSISSTLSDDSPKMVPPGTYQSGFSLPVCQSSYLQKRISSLNPPARARSNLTSNLNSIAGFEKSPSMNNGHIVRPSPINPMEQVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3F8</accession>
    <name>A0ABR3C3F8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616477.1">
        <property type="nucleotide sequence ID" value="XM_066756191.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988495"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0254256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="690" mass="76367" checksum="9DBC937C3A608638" modified="2025-10-08" version="1">MPKVPSLRSQSFGDGDSKKPPIPPALSITCAPCRSKKIKCDSTKPTCLNCAKSPDSCYYPPKQKPGLRPGTELLEDRMEGYESRLAEYEARLSQMHVVGPPIAYDLDHTPLSDPLHQSNPQGMYPPPPPGHPGHMSSNSLSGGIGIPTQQIPTSISSVISNPNPFSTDLSPSTTGGQFDRPSFNVSTSPNVNMSSPASFMDPHVLPSDDIVRDLIGLFFTHIHPWAPILSPSPPDFHPPWNIVHHAIVVVSLRLSRDPRIATSKQLIKQKAKQHVLAHAIESTSISSLQALALLALDLIGSDQGPSSWGILALLTRSAVHLGLSTEEDPNPWLGRTPMPSLSRTSIIPPPSTWHEDESRRRLFWLIFALDRYVCVSTGWDFALPDFDIKRRLPCSDSIWAQSEWYQTSLFRSVLHQEPIDLKLEDVSPMAHLVEALDLLGRAHTLQGEKIALGDARGLESRKDMTLTLTTTATRWFSMRPINRIQQPGMRLMIHAIYYSTLLKLNASYAYPALSNGEPQEPYVSTCLSSARSMAKLANTARSIGWATASTPLFIWGCWVAARVLFVHAFLNHHTQPDEDFEGIITSLKEQSEYWDLATQYVKLLGRAKRKWLNTLSTNPSSSLPDAIHVLLDLRRTAYSAVNTNVQETPHVSPPEPDLSQVPAWAVQPGLEDLYSWFDLPAGLFQGEAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3L8</accession>
    <name>A0ABR3C3L8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616516.1">
        <property type="nucleotide sequence ID" value="XM_066754615.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986893"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="331" mass="36479" checksum="D2A8FA1E0E7E0ABC" modified="2025-10-08" version="1">MPRSSNPRAPSSSNNPYSRSYQVVEAASIGPGSTLPHKSNVRCRCVLCPRGGRTMQFRTYINHRINLESSKAPNQSLSSSSGEEHNVAAPNLSSARLSDDISIPRHSPPVGQSPSLPDYACPLSPTGRQPHPYRDGPIFRTGPATRSMPLLTTVLAVLSVFLTTFVGVPQRLGDMVKAVIQIILELAIAEDRQALRRRVSDDRNLSPDMREKIHDILNLPFETSSSRFRKNVKTLYAQLDIDPSMAIHPKCPTTECQNVFIDVVDKDGWDKIPDNYPECGTALREGGRLVTEFFPRPTLQAELEFGVPLLSWWCRTACGGSTNLALSTKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3U1</accession>
    <name>A0ABR3C3U1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-binding Rossmann fold oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616570.1">
        <property type="nucleotide sequence ID" value="XM_066754669.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986948"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="149"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39162" checksum="67C7F1C841C95F41" modified="2025-10-08" version="1">MPTNVALLGGGIFAVDAHLPALAKLGTLASLKAVWSRSESSSTRAAEAWKSLTGQQVTRYSEDGSDDLENLLSRKDIDAVIIALPILSQANVIARALQAGKHVLSEKPVAKDVATAAKMLRDYQKNFQPQGLVWRVAENWEVEPAHIFAAQALKAGRIGNLNTFSISSVLFVDNENNKYFETEWRKKPQHQGGYLLDAGVHNAGVLRTVLPSPITHVSAHTALNNEHLPPYDWLSVITRSEPSNIHGQMLIDYGARGREPVWELRLTGSDGEIYSEDVNDNGVDSIKVQIRSGKFGRTNTEVKIFPKTGVYEEQRRFFEAIAGKPDGYGSVRGALKDVALIQVALTSNGNEVALNTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C420</accession>
    <name>A0ABR3C420_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616491.1">
        <property type="nucleotide sequence ID" value="XM_066754590.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986867"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF90">
        <property type="entry name" value="CNNM TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="4">
        <location>
            <begin position="154"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="916"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="965" mass="103592" checksum="FC4C41712C7F83E8" modified="2025-10-08" version="1">MVEDNHNEPPPPNIPTLTLPQSATTYTALARSTTVDSEAEPADEEEGDHRPFAPHTSTIDEHLTVFYQDENVERHVGRVRRSFAPLALFPIIALAFIPIASATNLDPYTSCPALPQKSTPILSAAGYIFNHVADFVGLHDSLVGQHAANVKRGLDNTAIVEACMVPVLVLLSGMFAGLTLGYFSVDQTQLQVLAISGTPKHQEYARLIMPVRKDSHLLLTTLILGNMIVNEALPVVMDGLLSGVVSVVVSTAMVVIFAEIIPQSICSRYGLLIGARMAWPVRIMMWVAYPIAWPIAKLLEWILGAHHGIIYRRGELRELIKMHAAGGEGGGDLDFDTVQITQGALDLARKTVKDSMTPIEQVFMLPIETKLDYETLGHVVKSGHSRIPVYQMVEIPDIDLSTPPIGPTKTKMVKKVLGSLLVKSCVLLDPEDATPLASIPINAIPSIPFDEPLTNMLNVFQEGRSHMAIVSRHVRRVGPVDPEDAQSVMTAAAGGLRQRFFRKVAGISGNRSFSDSDSSASGEEDLEKGEGGKKKKRRGKKAEKHDRAGSGSSNDHNAIRPTSNDVDDLTEAGEIKRMAKEVQEAEMKHQRGKESKKGSLVQAAKLTQLEQSVPADAQLSNDAVENFFDGLEGAPLGIITLEDVLEELIGEEIYDEYDEHGVPRSAASAFVPLEAMLAARKAALARQELAVAQSTPLPHVNDADFEQVVTAPTPGAGRRVMARIQIPKFSLKKPPSQPGRLRAEHLGANETPAATPPVGPPGYSSRPDEKSIYSAQVVTTPVELDEQPLACAQSDNRPVNHRLSTPPDSGAATTPSPQPQHGSSTPVLASAVPTRLLTAGATGSTPTAMPASQQSSLLNEAIFIERERRRMAASHPGQVRGQSSGPIVPSPRQLTPPMSVSNFGIQVTGVNGERVEGQGVVSPQPIAAQRKKVPKFKSVPTPVATPSSGIDPVAGSKSSSKGEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C479</accession>
    <name>A0ABR3C479_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_100229</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616702.1">
        <property type="nucleotide sequence ID" value="XM_066754801.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987087"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045752262" description="CFEM domain-containing protein" evidence="15">
        <location>
            <begin position="19"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="98"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="102"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0255425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="292" mass="28656" checksum="0F81FAFA59127D72" modified="2025-10-08" version="1">MRVTTLVSAASLLAVATATPLRRQNATAPQCAEDCFANVDTIESVCSSGDIACYCTDPMIVGYLRSCLSSSCSTADVNNAIYYGEEVCAANGADVSMRNDGSSTTGSSSATASSISSSTSSSYESSSSTTGQTSQVSDSVTPTTLSASSKANSVSSSVAAEATSSNSATPESQTSSSSSAETSAVAAASTSTSTSTPVSSSTSTSSSSASSSAPSSTSSDSRASSNAASAVSLISSASSKTASTTASGLAASSGSTSSGERVIGGVTSVMVAAIRYNLAIAFHGRCWAPFHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4A5</accession>
    <name>A0ABR3C4A5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616737.1">
        <property type="nucleotide sequence ID" value="XM_066754836.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987122"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="166" mass="19602" checksum="661BE179A5BF1B2A" modified="2025-10-08" version="1">MDRKKRTTQKPASSSRRDKTLPLPSPNSGSRTSASPEQPIVPPLGDSTSIFDERWDVYFHAFLLHETKHSDCYYYKGQWWFPENRRNEQTLHMFVAARWAPLEQHEPKVATLITWQYYNLHLPNGKIMENLMFRYVGQSNPQEEWLHDYVGYNLNLVTIDMQVMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4B4</accession>
    <name>A0ABR3C4B4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616750.1">
        <property type="nucleotide sequence ID" value="XM_066754849.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987135"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="12932" checksum="C8AA310691DC6623" modified="2025-10-08" version="1">MPPAPTVQQIQSLYSATVTASQRFASYNFHKYFLRRTDEVFKPVLASLAPPAGSAPSDPIDPSTLARFYEHQKTQLEILERASKVNRMYEGPKLVVEHARPITSGGGAGMEASAGGGGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4P8</accession>
    <name>A0ABR3C4P8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616879.1">
        <property type="nucleotide sequence ID" value="XM_066754978.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987265"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1439"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="895"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1440"/>
            <end position="1453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1567" mass="170364" checksum="D686575CCA7CAF2B" modified="2025-10-08" version="1">MSTSPKYYHASCSSSRSASRQDDRPPSPQTRAQVRSEAIARLKRAASLPRSPDGRRPLQRQAAARTDDRSGDAEGSPGIMPVPVEVSSLLGPDSPSRSANDEQEVLSPSPVQTAFDHARIYPSIDPMQMQRSASASPSYNMTCNDFPPPTNGVNPEWHTMQLAQSYVPSLAPHGSNSLQQQVPLAGRNTPSPLPTLGELRTLQRSNSQAARARAMSKLTGGTGISMNDDVSLHLSLSGSLQRAGTLGASANPMLSMPSRTGAGFSTPSAQDSRQATAFDAPRPRLQRSFTVSSSNMGEERRSAVGRRMVERLAERRAARHKEEEEVRRLWEGRKAAADLIGKGQSHVIDRPGKEEQERHQVTPSVSKPPGDDERPIQAAATAAPNMLLAPERPVSGGTMQSAQFEYEDHLRRSLSSRTARGAMGAVSEPVPAVTMTNVQSEATDQDTEQLDTPTLPQNPMSPYPESQAFGASVLDLDEPLLPPHPPFITPSRHIAHDSTSTIHGSNNSPGSSSTLGGSSILSGLDSMMFVAGGTGEHYAQSASRGETNWPVEAAESSDWGTPGKEIRQTNLISSPSSSTRIDRPPSSTSEIFSTQISETGGTENGHYSPKSHDPYGMSSTESAMPSWEEVSRKEEQVYKAPVNHSYHARSESVGARMKRTMKSAMRKGSQSQSSMTSASPPMSPRRGSGASATPSQGSAAKSWPKGEPVATTRIAIHHPSISSLSASQADSAVASSSSLIQHQLSSGPSQVSLLPRANLNDPRIHMSKLSPFPGLEHLESRAAGYEGFPGKKPKLVQQVSDSVIPSYASALTPGGTPATENIYALPLVARPEANKRLSDESVTKRNWLTKALTPRTSLSRKISYGDVRSRGNSLGQGAMVISSDVDPFASPSTGAVPTSSAPSIPSSMSAGGKPRVASPTVSTVPEMSEDRTRATRPIHLRQGGNAPGIMQERVQMRKEAMLPKKTLDILRRMDEVLALGPEHPARPEMLDDPPRKFLKSSQILQVVNANIVKDRFLFLFTDLLVIAKPILAHNVHATLDTQFIVKNVVSLDKLVISGPQGESPADSGRHLVVDNFVDKFKQNPVEACRYLVEKCSPKVDLATLAGLILKTSELDKTQVGLLLANNEGLTRAFVDRFHFRNIRIDEALRIFLLSLRLPTDPISCETLLKVFAERYYVANHEHLAYNQELAIELVLTIMQFNDALYSTFDCASANNVITRETFITAFRSKDPLGLVPDDLLSQIYTSVRSIRLSQALASSELRIERRVIATLPHTSTKLTYNVWSEKIYISIPAPDSKFRVKLLGEGLEFDPPELDFANKTEESFRVKGTSLGMKALLFVRVGDNAALYASLGSIHHFNVERAFMRHTFQIAFSNHVGLKRKYCFSMNSSVSCQKWRELLEKHIKETKGTKSIKGSSSRDVARQAAEAVSLQVLRDALISTEETAQPTEENTTFRPRGNAAAQPESDIGPRSRTGSISAVYAQFALKKEYELVSLQPVQGENDMDKASQKGNTRTGKELVLLCRQNSLMPGLLNLLLAGAEYEPEDAYAHEGSVDRDANVLRSKGKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4U7</accession>
    <name>A0ABR3C4U7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616927.1">
        <property type="nucleotide sequence ID" value="XM_066755026.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987313"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="169" mass="19326" checksum="A6211F051B00756F" modified="2025-10-08" version="1">MSNTLRPYLNAVRATLTAALTLSNFSSQVVERHNKPEVECGTSPEVVLHPLIISRNESERVLIEPSVNSIRLSIAIKQADEIEKILCHKFTRFMMMRAEGFVILRRKPLPGYDISFLITNFHSESMLKHKLVDFIIQFMEDVDKEISEMKLSLNARARIVAESYLSTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4Y7</accession>
    <name>A0ABR3C4Y7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pheromone-regulated membrane protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616955.1">
        <property type="nucleotide sequence ID" value="XM_066755054.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987343"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="780"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="860"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="896"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="950"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1074"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="678"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="972"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="471"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="615"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1108" mass="118799" checksum="CD3C253E3D7C95BA" modified="2025-10-08" version="1">MSIPDNPFQPPISTSPPVLQTEATSVDDRQTINSDINDVSGGLMPSGSPHSHTSPLPGSVSPRPALSNLQQLGGGVKTPRRVQWTSHPHIVQLQPTEPAPASPHTLDSSNIDEFRNALERHQYGATGTSGARRRPPSQLSRQSSASESVTRQGTDDEEDYDYRTDVDPPMRPSIERHDTDETTYEANLIDNGMRGHVFEYIAPGETDGLPNIPQMANENQHDAARDLVRAHTGKWGVLRRRVRGAGAVKGALSAASSNRKRDGKEEEQEKRRSGEHDRESQEAFAARYPEPGRSSSAGGFGGGPIPGGASVLSSLLALYGQQNGQHSGNTSAASSRRGSEDDYSSGDEQSSQKGGRHAWRNIGRRSADEGLPAFAVHDQPHPSNVQAPRVSEGSLDPSDPTSPTSAGFGPNSGPDGEYSRSQSGYNGTVGSPGFKSFFQRAKEQLQYHRPDAAKNAGGVFGALIQNTQNLSGAATPAGSTLAPAAKRPGYQLNRYSLPDVGADTRRGPWRPPSRPGSVAGSRGDSRPASIHSSTAVSGNGDSPKDDNGNPFGGKKAISSDDLMSMRKANESTLSLGRKRPKTGLHLESLAHLPVAAVKGGGKQIKNAEKWLLHGKTSLGTPDEKGGPDYFSRPLTEDERRRKEWEAEKKKRKKAREARKKQEIFIIQHVAAILNRQQFLLKLARALMMFGSPSHRLETQIQATAKVLEINCQVVYLPGTMLVSFGDDATHTSETKFLKQSTGLDLGKLQATHHLYWNVVHDKMSVDQASKDLDVLMTTPVYYTWWQTLIIGAFCSAFISVLSFYGSFVDALMSMVLGATLVGVQMLAARNDMFSNVFEIAIATLISFVAAALGSTHVFCYTALVSGGVVLILPGYIVLSGALELASRNITAGAVRIGYSVIYSLFLGFGISIGAVIYSKITQKDVLNSNDYTCGNTHYSGVPWYMKTPSAWWYFLCAPGFSLGLSLRNQQPLWAKELPVMVIIACAGWTSNHFSSLAFPGRSDLTSAIGSFVVGTLGNIYGRFSNGSSFPVTVPGILIQLPSGLSNGGIFNFAAESSSGSSTAYSDGFSVAEQLVSVAIGLTVGLFVSAAVCHPFGGGRRRGSGIFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C527</accession>
    <name>A0ABR3C527_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617005.1">
        <property type="nucleotide sequence ID" value="XM_066755104.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987393"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="279" mass="31718" checksum="8838862B29F039D2" modified="2025-10-08" version="1">MHSLVSILIHHLFSIATSVLLFLLSLGPIPQHVAFVMDGNRRYARELGQQVESGHTEGFNALRRTLEICLRLRIRAVSIYAFAIDNFSRSEKEVGTLMNLAKQRLTELCQHGDLLEEYGVKIRFIGQLDLLPPDVLQAVRNMEAMTQGNKNGVLNVCCPYASRDEITTAMKEIVQRAYEGDLAPSDITAKDVFDSLGVSKAINTVDKSLFVNPEEPEKLDILVRTSDVKRLSDFMMWQACDDTQLHFVKTYWPEFGLSDMLPILLGWQQKVWMRKLGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C578</accession>
    <name>A0ABR3C578_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617047.1">
        <property type="nucleotide sequence ID" value="XM_066755146.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987435"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="617"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="617"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="807"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="821"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="917"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="975"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1012"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1084"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1126"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1151"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1194"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1219"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1314"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1331"/>
            <end position="1347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1519" mass="158582" checksum="7CFA76C6073CBF2B" modified="2025-10-08" version="1">MSYPYLARTTLKYKSPHATDLSFAKGDTIRVTGPSPEDEDWLVGETLDGSQAGGFPKDFVEVIDEGSAEATENESKTVEETAQEPQPVTQDSSKQLEPPDVQSETDSKAEEVPSELNIGSSEPPAPAPKVEEAPSEPSVGASEVPPAPAPAPAPAPAPAPAPAPAPAPAPAPAPAPAPAPAPAPAPVSAPQSESHDDEAPRPQSMKDRLAFFTAAQNKPPPPPPVKPKPAAGGLTWSQRQKLRQEQEAKEKESTIATSPTTSTPIASSGPSIPESKQKDDAENKEEQGTAMSAADALSSISKGGSLKERMAALQGVGAFGGAEKKPAPPAPTGKVWKRPPVQEKEPEPEGDMAAENQSPETGLTHKPLPSSEEAREPESDTKDEVAKEEETEEEQEKARRAAIAARMAKLGARGPMGMMPPAKPVKKPTRETGITAEDKSSTSAGFTSETAKDDTDQITEAPGVDSKPSTLSKPGSVSAPTDAPVTAPPQSIPISAMPRRTAGPRRRTHASSANPSSEDVSTPAETHPVPLPSTEASVSQDAAAPAEAEAEPDDRLETINSEGYPVPPKQRMIYDEEAPLPKTEEQIKQEKEAEERGRGIGGLEGAKAAGIAVDKIHGAPEELAGHRDEPQGSLEDVTHVDEPVADSGASQDMSRGIDTATTDLGSGGSKASVEEQSIQGGVDREDETSIAQDEDLKASESTPAHVAESDKVGPMGTVPLTIGADVGSPVGGGTSSRGETTTTMEEKLLYELEENDSQNAGEEPALESPVSDSEISKEDEETAPPPPPRSVRSAVSAHDTAPDVPSRSLTGFTTESNPTEAHAQPQPQARASPSPPPPPGAAQLGEENPKEDISESVGNDASEARSEGGDAVEVVGQEGEGTRVPPPPPRIRKAASPVELRGESPTSEEEPAPAPIEETKEKPSETARDGVEETGVPKEDEEDAARRSGIAARMAKLGGIKFGIPPPHPMKSHSVDTAGSESIPSRSENLSPVENEPPPPPPSTGVEAEQQQPERDDQGKEEAGSEEETPEQEAARRRATLARLRAGGALGFGMFNQPSPMEAEDVGQKDDALEAKDADTKSNEEEEEEEVGEDEEASVEGGGPPPPLPSGRPGQGMPPFNRDVGTGEEEATEEQEGQGDQSQDEDEEDLAPPPPPPPARPAVNTMYGGNDAPPPPGAGTLSPVDPSGISRPLVSEREGQERSDTYESTAASTDNRRLPPIPSVPPAFSPPPRHQGVGEEGGDENPPPPPPRAAGHRGSVHEPSMPGASMPGGSMQGARQASLEQPRSPRGSVAPPSQMRMSPEPYTGGGGGAFVAPASASAGAPPGPSSQTNPNPKQLSGDSQETSVPLGRYVSASRQGTKPGYDQLKEASVNYGQGLVRVARGIFAQGKKGFYGDGSASGFVAVVMDNAGVPRPSGNAWGQVIFEQEAGSILRRYDEPRPGDIAAFYDAKLKGKKGLHTYSQHVGSVEKPLVGVISEFEDRKHKLRVLQVERGVPDEVSYRCEDLKGGKIVVFRAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5G3</accession>
    <name>A0ABR3C5G3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase I, II, and III subunit RPABC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617139.1">
        <property type="nucleotide sequence ID" value="XM_066755238.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987530"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9282" checksum="8A642D24146FDB3A" modified="2025-10-08" version="1">MSQPQSRYTQQNPNPMPDRNVKAPETISYICGDCGAQTAMQPSEFIRCKECGHRVMYKPRTTRIVGLIRYIYDTLNDKPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5Y5</accession>
    <name>A0ABR3C5Y5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_100700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617166.1">
        <property type="nucleotide sequence ID" value="XM_066755265.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987558"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="214"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="458"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0255889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="610" mass="66343" checksum="168BF8049DF84A6F" modified="2025-10-08" version="1">MSPILKRDIADQIRQTKRLAAAVIGSSYLEDESYRSPPFEEQPENQILKLENTKDGDRGGPAFTSSSSARQGMGVHRNEIEQDHDYREAKWLNTKAAAADGKGKGKAVSEDLGNLPEDEMDQLVSERPSVDSWKDNGPLDHGFPGESFGYAEPELEIMSSSTRGDKWKDMMSLFLEATPSILLSLVGLVFTGQLLEHLARWRVFRRVDELFILVPMIGNLKGNLEMCLSARLGTSANIGELDHRVTRRTMLMANMTLLGLQSLIISSVAAFISFVLGLLTIHRLGDIPEDASYGNSTNPGLESADQEWHEGYTRPGWKQLVMVLATGMGSAGISSAVLGSFMGSLVIVSRWAGADPDNITPPLAACLGDLLTLFILSLLGTALVGAMDTVIPLLAVVIMSIAAGWFTRRVVRNVWVKEVAKGGWVPLIGAMLISSGTGMVLSKGVGKYRGFALLAISMTGLTGSIGAIHANRLSTQLHALLHPTHPHPRPVASLSSLHGGHSGLTPFHRGITLFLIAYPCQGAFLFFVTWVGWVDTSLGWTVWVAFSAITLMSLVIAHYLTLFFWSKDLDPDSYTLPIHSALVDFMGQLLLMLAYETCISLGRDVVVKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C678</accession>
    <name>A0ABR3C678_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribitol kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617256.1">
        <property type="nucleotide sequence ID" value="XM_066755355.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987648"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="5">
        <location>
            <begin position="323"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="67885" checksum="08BD77400A780E08" modified="2025-10-08" version="1">MSDMEYFIGFDVGTGSGRACLVDRNGNLIAEHAEPTLTHRSPTDARIFEQSTGNIWKSLSICSKKILAESGVKPEQVKGLGFDATCSLAVVNKQGKPVSVSRTGQTEEDEKEANIGLEGQWNVILWADHRAEEEAEKINSTGEGVLGFVGKTMSLEMEIPKTLWLSKHMAHERFKQCMFFDLPDFLTYHATSDLARSTCSLACKCSFVPIGAIMTHDCDGGKEETSTQGWSARFFEKIGLQDLVKEDFASLGGIPGKNGLVLTAGQPVGKGLNKLAAKDLGLLEGTAVGSGVIDAYAGWIGTVAAAAGEDQAQPTLEDASARLAAIAGTSTCHIAQSKDGILVPGVWGPYRDAVFPNLWMNEGGQSSTGQLIDFMMQSHPAYPKLLELSKSSGKSTFELLAERLETLQKEKGAKTLTHLTKDLHFYPDLHGNRSPLADPRMKGMITGLVLDDSLNDLAAKFNVTLEAIALQTRHIVDEMNAKGHKIDSIYMSGSQAKNGPLMRLLATVLQMPVIIPPQPSAAVVLGAAMLGRYAYDLTTERHGKPISSQQEAEEAKEKDGWRLWDVMVQMTRPGKRIEPRNDKFGASEKKLLDVKYKIFREAVEVQRKWRQMITDEVKDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6F1</accession>
    <name>A0ABR3C6F1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Metazoan SpoT homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Penta-phosphate guanosine-3'-pyrophosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100527</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ppGpp hydrolyzing enzyme involved in starvation response.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MESH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616997.1">
        <property type="nucleotide sequence ID" value="XM_066755096.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987385"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052194">
        <property type="entry name" value="MESH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46246">
        <property type="entry name" value="GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46246:SF1">
        <property type="entry name" value="GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13328">
        <property type="entry name" value="HD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="7">
        <location>
            <begin position="94"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="287" mass="32211" checksum="A8236A61AE35DC28" modified="2025-10-08" version="1">MPNSISINSPPTTTRLLQESSMRTQYYSEIELIRTPPPRSFTPTPPMSRSHSPNGLPTAPTPGRLHGESDLSLLLRTLDFAARKHSCQRRKDVDQSPYINHPISVANYLSSTGVTDIRVLQAAILHDTVEDTCTTLEEIADQFGNDVARIVEECTDNTALDGLQRKVEQLQTAPSKSKQAQQVKLADKLHNLESIRRSPPVGWGIKRVQAYFIWAKKVTDICAPAHPPLAERLQHLYETAHTRVNGTYFPCHPEVCGPLTEEEKELVDKRLRELKDGDTVCPEPLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C7M8</accession>
    <name>A0ABR3C7M8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein mago nashi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616781.1">
        <property type="nucleotide sequence ID" value="XM_066754880.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987166"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="18076" checksum="4DA7346EF070D9FF" modified="2025-10-08" version="1">MSTEDLLRDKFYLRYYTGHQGAHGHEFLEFEYSYGRIRYANNSNYRNDSLIRKEMFVSPAVVEELKRIVRESEITKEDDVSWPRKNVVGKQELEVRIDKEHISFETAKIGALAEVNDSSDPDGLRVFYYLIQDLKCFIFALIQMHFKIKPIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHN7</accession>
    <name>A0ABR3BHN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BING4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610730.1">
        <property type="nucleotide sequence ID" value="XM_066761190.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993624"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="321"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="7">
        <location>
            <begin position="409"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="494"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="624" mass="69667" checksum="59660C80891D73B7" modified="2025-10-08" version="1">MDALLAAAGPLPQRKGRPDKIHQRTPHPTAHKTVARGNGKDDIDPSTQSILSSTRLPHSFHRSNLATGSSSSPIRPDGTLGRIGDKKLRAKIALQDVGNKRAKVERDDVNEWINKAIAGERGGIDVDEDLGEKTWRVKQEEIVKEVAMNVRGKKFDLKMEDMGSYKVDYTRNGRHLAIASSRGHVATFDWQAGKLHSEIHLKETVRDIKFLHSEAYYAVAQKKYVFIYDQNGVELHKLKQHIDPTHMEFLPFHYLLSTVGNAGYLKYHDTSTGVMLTQIPTRLGSPHSMAQNPHSAIIHLGHANGTMTLWSPNMTTPHVKLLAHRGPVNGIAVDPSEHSAGRYVATSGMDGTVKLWDGRMWGKEVREWKTRNQITSLAFSGMGMLSVGGKSGVTVYQDLYKNTHRPPSPYLTLPLPSLTASATRFCPFDDLLCVGHERGISSLIVPGSGEPNFDSAEADLYETRTRRREREVRGVLEKIRPELITMDTNFLGKISEGRGGETHEEREGRSFRQLGRLQRLHLTGKADEPEQEGDNDEDVGLDDGEADPNSGERSIREKKERRKMKGKGGSTKRYLRKKAKKNIVDNSLLQMKAKVAAQRASEEKKRKVERGEIVQETGALARFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIC1</accession>
    <name>A0ABR3BIC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_106690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610937.1">
        <property type="nucleotide sequence ID" value="XM_066761112.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993545"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="273"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0240438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="364" mass="39486" checksum="270C0BA806D5FF55" modified="2025-10-08" version="1">MAPKDRTSEFHSTLNSIKSRSALTANRAKGKQQDREAKQPLISNGPGQTGAKSEFGKMAGGIAKDINSTTLKLQKLAQLAKRKTLFDDRPVEISELTYIIRQDIASLNSQIAQLQAYIKSSKGGKGGSAASGGKGKGSGGKQEEEHNNNVVMLLQSRLANMGMGFKDVLELRTQNMKASKDRTEQFMHTAQGSSVLAPAENSLLFNQPGDRKGKSRANTPTPNPNSAVSNLGSKRGEKEGQDFLALDIDGDRGESGIGMGGDYQQMQLVEQQDTYIQSRSSAIESIESTIAELGNIFSQLATMVAEQRETVQRIDADTTDIAANVSGAQRELLKYYASVSSNRWLMLKIFGVLIIFFLVFILVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIE6</accession>
    <name>A0ABR3BIE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610967.1">
        <property type="nucleotide sequence ID" value="XM_066760695.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993117"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="686"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="885"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="4">
        <location>
            <begin position="1092"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0240468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1281" mass="140413" checksum="AA68C5D0BBE87F08" modified="2025-10-08" version="1">MASDSTVFTNQSGLAPPVSPHSGSITSLASITMGQRSNSNASRASGTSAESEAVNKDELDRLGYRYSLRVAVLHHHLCNAALSPRKRLSSSSSMSHRSHVSGASVPPLASPPATGNSPNSSRFTSLAYNTPPHTPEPPSPSTTPPILRRKSSAWALGKHKDDGDAVKLPKDFLLEFWGTLGAEEGDLGWESAVKGFTSIIKKGSKTASGLNLREIPTLLEVFSSYIPPAGPGCAAKHVHQSHFLQLLYNVLPRSSYFSPMTRTQTEKEKELLARLRTEVQSYMLSPSPLPNADTGSSGLVTPGKKSSVSIGRPTGQDSVRRKPSPVWDGDVNEMMNTVGQVWGVRKETLDRDVSEITSGKTSIEQFYMADLKRAMTILSAQPPPLTASQKNRQTYLSQALSNILKEFPDLATPIPATDYDSPMSPRGGASNTFFTPPRTVEVFGRLATRAAEAGHGSKTRDLLERCREVWGISSKREKEKEIEELIARWEGSIATKEEFTIAKNIADGIGLIAIGLRPGDPLPAVLSQILNRLLEMASKSLASIFPTTSSTPLAPPPSLLLIFNSSPELFASQPEAAKVLDNLSDEIKASAIGEYVAAVENYLGGIGMSDAQVLKIGDSGKDSVVEGLEKVAAWMEKEVSNVKKVWGRGLQTILDPACIIIKCQLPLFLAEIHSLEKPRGSASDIFTLYEITGKLLDLWDDLSFEQDHGFDLDGFFEPHVRAWLKDTEANRVGQWVERSVGMDSWVPEGENRHSQSVIDLFEFVRGSAQVILHELPLSEYKRAVYLIDYSRTVSYAINQYASIVLGLFMRDMNPVKAPTPASELQGKLGGKAGSWFAKGQQAVKNLERKKIEGFLIPPAACVKLTDMGAAKTCLEDMSFAMEAEDTARIIKAHHLSGAQPDKAIRHVFTVSILRGENLLGKSLVKAADGFVVVLDKQSGERCIKTKTVLGTEDPKWDQSFEISVGAVKILELQVYDRQLVGKHDLIGISTFKLDPRLFADYPTRDVVLPLNPRGTVHVRISMEGGEKHDVQYHLDAASRICDRAAEDMVREIVDKMGEFIKAQLSVATLQTLTKPLKDKKRTKTALTEHDIEYSLGLLFEYLNENFSIFSVTLTFNTRIRVMLAIWHRIIEMTISLLVPPLSDKPYLAPPLPPQEVDIIFRWLQLLKSFFNAAEDGTELGVPLSQLQSGPYKDIIMLGQYMDLPTPTLKERCSAAVRAAGAGRSGGLSNGMKGSSLEGNDNERMAEVLLRIARTRPDTAEFLTHEITLLTKTRVEKQAGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJD7</accession>
    <name>A0ABR3BJD7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611292.1">
        <property type="nucleotide sequence ID" value="XM_066760531.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992939"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="270"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0241910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="491" mass="54785" checksum="804747D7353BE96D" modified="2025-10-08" version="1">MPPKGPNTLPLPYSQVPAQPKREQRQPTRTSKLGSKLKVLPTQPETPTIPEEEEDDDEGTGRTVADHDESEGVEFYTPISQIPKGTARRDAQRLTKSEKAKLPRVTAYCTAATYNLQAMQAYLASRPAYHRTHPRMFDTECLHTPYLPPPTPGPHGISSLSAHRNSPRLKPASGAGHVPEGDLLNLGNDYSSGAAAAHKRATSPSRSNQNQNQSPNELKRRPGFSKRPGSGRKKSASGSTTTKDSTAADGMTDSEREEDDDLEEEWIPDVFLFEYGCVVLWGMTEKEEKKFLASIKRFEIERLSAEDVEMEDLNFYYADYSRIYNDVITLRKGSSYMTKLSLSHALSQSVKISLFEELIMGTIEQTKDIPKSLSETGKIGLPRSEIMKQIGNLFILRININLVGSILDSPEFFWTFPDLEPLYNAARSYLEIGQRVELLNARVDVLQDMLKLLKESVNSSHGERLEAIVIFLIGIEIVLGIITILVDLSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJZ5</accession>
    <name>A0ABR3BJZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Formamidopyrimidine-DNA glycosylase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105732</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611486.1">
        <property type="nucleotide sequence ID" value="XM_066760182.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992587"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="11">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="263"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="329"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0242104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="482" mass="54401" checksum="1934B6F7EDBBA031" modified="2025-10-08" version="1">MPELPEVERARKLIEDSCKGYKIASVDAQEDRIIFTGGTDHNEFAKEITGRTITGCERKGKMFWITLSGEGRYPVMHFGMTGMIQLKGQEPTWYRRRPKESVDVWPPRFYKLVLRLEPQKGSIGDEPLELAFIDGRRLGRLRLVSDPVSSYPPVSELGFDPVLSHPTLEEFTKLLVNKKGTVKGVIMDQAFSAGVGNWVADEILYQARIHPSCPIPALSEQNIKDLHHQLRAVPLTAISVNADSKLFPSDWLFRWRWSKGTTQKKQMEKDKKTKGKKVVDGEGGEDVEPEDKEFLELPDGSPATIKFIEVGGRTTALVEELQKMPEGVKVKPKIKKGGKVAGAKRKKPTKEEESDEDSELSDQSEPEEKEPERSFTARQRAAAEKKGVNNDSAWQTKSEDTKSSAAERRTVRARIGKSKHHQDSQVKKEEASKRPRISKKQLEAVEEKPRKVKPQRGRKKAASTPESSELSDVPEYFQDTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJZ8</accession>
    <name>A0ABR3BJZ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105742</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611496.1">
        <property type="nucleotide sequence ID" value="XM_066760192.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992597"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="158"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0242114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="411" mass="44539" checksum="ECEFE6F24EBF8D11" modified="2025-10-08" version="1">MPDRKDVHNFAAGPSPLPSTVLEDAAEGLLNYADTGMGICELSHRGKEFKAVIEGAETNLRKLLAIPDNYTILFSQGGGTGQFSAVLLNLLSAHRLAHPVAAEEFKPPTIDYVLTGSWSSKAYAEAQRLVLPPFPNCPGFATPRIAATTKSTGWTSLPKREEYDFSKDAAYVYYCENETINGIEFPPASAQDSAYAFPFDLVPEGVNIVADYSSSFISRPIPNIEKHAIIYAGAQKNLGPSGVTVLIVRNDLLVDTTAAAKLGCVPATPITYEYKILAENASLYNTPPTFSIYVSALVLQHLIDAKGGLTGLEATNREKAKLLYATLDAAEVKGKVKTVAREKDARSWMNVTFEIVGEGKEKAFLEGAEKKGFKQLKGHRSVGGIRASIYNAVTLDSVKALCQYINEFCEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK46</accession>
    <name>A0ABR3BK46_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611356.1">
        <property type="nucleotide sequence ID" value="XM_066760595.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993003"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019084">
        <property type="entry name" value="STM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09598">
        <property type="entry name" value="Stm1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="4">
        <location>
            <begin position="133"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0241974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="345" mass="36592" checksum="D772F68BACF82DAF" modified="2025-10-08" version="1">MSVVSKNLFDLLGDDESPAPAAPKAAPKKSEPAPAQRNVPGAAPRGNANRGRGNNNRGTHTVTRDDRVADNEGTVTAGGFDGERVPASRKGNHTRDAHTKGPRGSRPAKTSGGHTSAGNGHYRGAKVPAQAGERRQFERRNPTGTTDSQKKVEHGWGVNSGEAELKDEVEGEKDAKVEENAPQTPAEGVVGEAEAPAAEGEAEQEPEEVTKSYEEYLAERAQQNAAISALGKKQTREVASEIEGKAFVREAIDDFFSGKSKSTEAKAKPKKEKVFIEFDGQFAQPSRPPRRDREGGERSGERSGRGRGQRGGFGGQRGNTRGGARASRPAPINANDTKAFPALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKA1</accession>
    <name>A0ABR3BKA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611416.1">
        <property type="nucleotide sequence ID" value="XM_066760655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993077"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0242034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="121" mass="14548" checksum="71CEFF167BBF0C7E" modified="2025-10-08" version="1">MLKHQLDLKRFLVIQLFSLREISSDLVQHGFFILLYCLRQFNIFFHLQRKLGRNAKQRYRTRTFGFTGITRSFVASRLFFREAVSIFTAWKPFALTVVTHREKLRRGASGIFRRVYNTDHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKB8</accession>
    <name>A0ABR3BKB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105853</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611606.1">
        <property type="nucleotide sequence ID" value="XM_066760302.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992708"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="714"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="450"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="883"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0242224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="943" mass="105106" checksum="7B3D8431A064ADBD" modified="2025-10-08" version="1">METELVNHGDVFSSSPGRAPEHEQYRRTKSDDANSTVETGFAPGNKSQLSIERIFIPKKKKPLGMTRRQGAPTGSQSSAGLYQGVAKTSAMDLRRQRQMGKDKGEVELRTLGAISRAESESNKEERKAKNNRERDEGNGRFKKEALQPSRASRSCSAVHDSSDESDSKRTKRFKKTSPSSSNREADSVFEQLLATERKLEKLYNQTTSATRSGVTSRKVVDATRKKGKGRESEPGDLPSPAKRPSTFKSSNQTTSNNRAESGARSSTAFRSTSSSLSFSAHKIKKASKTKSRNTFDGIPRNPFVSVTKSKIKDPLLSTTVRVSDTENDEDDELALGSTPPNHQSNGYRDKALVAPNSSLSSDVDAFNLMYGSQSSTKATKNVRRPSGRDSDVLVSTSEESMVFTPKPSRALAKSDRVDTVIKIAKTKATKRGSSNSSDNDESMVGMFKGKKRALSVEDSTPKARNAKSIREGAPRADAKVQDEESDEDYVVHAKKPPVKLGKTVVSHCYGKKTVNSDDERTTPAPLTLQELPETPQKKREGTARQLLARDNDKGFYFFETLSSNMDSSDYDEFDDEFLDGPSILVNAEDELDAETMALLGEDEFTTKEREYLLSFMDWTNRCPYCNLPLPNEPSQHHEYLKAKLHKLSTPAPTDENPNARALSWQKAIEFCSLHRAETTIIPLGIRAGFPVDINFGNLDRRLESGWIRNELDKIVRQPEKSAVFRKVKKEVEKVGRIKWGSLAHQSKEERLAAVKPGYYGELGRIIITDHFQLLRRLNYMMPNIPPAKSSSELTQDVVTAIDPLSPSDFIANVLVPEAANFLIMQDRGQKEFDQTTYEAASKTRAESSKYGEWKFPEASKSSKTVLEVLRCSIDDKRRRLAKIRGKKKTKSGKEDLETESESGYKQEDANAVDESPKKLCRSSSVYDEGWEEDHWESAAKLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKG6</accession>
    <name>A0ABR3BKG6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611624.1">
        <property type="nucleotide sequence ID" value="XM_066760320.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992726"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="8">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0242242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="364" mass="40173" checksum="F15C4DE700C2CD0D" modified="2025-10-08" version="1">MDKSHPLLANFDDPPPFPETYPQLRRLDRSVVCQICKEPFTAPVSIACGHSFCSHCIRSSLDVQKKCPSCNEPASEGSIRRNRALEEIAEAWEQSRPTLIDLSKPVSRKRAAPDADSRPSSSGTIKRLKDQDGKRSQSPALAEPIDSEEEDEIQELTENDEAPCPICMARMAISSIPMHVERGCPLPPKTIKASAGGGKGNQKADWKKVFSGQTLSASKGKESGKGREPEMKKITKPNYSLATPADLRALLSQYSLPTSGDKVALIARVQEWIILYNANLDTSRPSSLSALRAKLAEAEASRKRDKEKGKDELVEQLGSKDGLAKYAQEKRSEFERLRKEIMERDKKRKAEGKGSGRDSAIEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKQ7</accession>
    <name>A0ABR3BKQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_106187</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611395.1">
        <property type="nucleotide sequence ID" value="XM_066760634.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993042"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="67"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0242013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="575" mass="63543" checksum="A1F601A241431F82" modified="2025-10-08" version="1">MSSAIEKEGSIRGRTSQEIVSASYDPKKSGDGVDTVVTAAHGEKGGYEDEGIHPGEGTVRRQLKQRHMAMIALGGAIGTGLFVGSGSALASGGPVGVWLGYIFMASMVYSMMVALGEMAALYPVSGAFTHYASRFVDPSLGFALGLNYWYSYAVTLPTEVVAASIVISYWDTTTNVAVYITVCLVLIWFINFWGARAYGEAEFWFSSIKVVTIVGLIILGIVLMCGGGPNHDVIGFRYWRNPGPFAQMTINNGDGVIPGAWGQFLAFWNVFVQAAFSFIGTEIIATTLGEAENPRKTVPRAIKRVFFRLLFFYVFGIFVISVLVPYTSPNLLNGSGTATASPFVIAIENAGIKALPSIVNAVLLISAWSAGNSDLYASSRTLYALALERQVPRFLRRCNKRGLPIWCVVITGLFGFLSYMNTGGETATKAFDWLYNLSAITGIITWWAILLSYLRFYYGLKKQGLSRDDFPYRAPLQPWLSWYGFIFFTLIILFNGFTVFLKGNWDTSSFVAAYITLPIFAVCWIGWKLVKKTRVVPLAEIDFHSGRRELDELEALDEERFKPETKYQKIISVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKV8</accession>
    <name>A0ABR3BKV8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610875.1">
        <property type="nucleotide sequence ID" value="XM_066761050.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993482"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF4">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="111"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="770" mass="86476" checksum="3B0140EB82A5613D" modified="2025-10-08" version="1">MADKEELQERIKAAREEYREYLQLAQQLQGDLREDAEQLRVQDGWDEDMWNGVEEWIDDLGSIWRALRRNRYDQDKTHSFLLTALSTRLSLSLHDPIPSMLPYSESPLFHILPLPSHTDKLNRPIVVLTVRGVVRDEQGMLDDLKEWIWWALEMCRRTSKDWWSRGMWDGNGVDGYGRGKGKPRGEGGEGIVLLVDAAGAGYRNLEVDLLPTLLSVGHNSFPGLIEAVYVVNVGWTGRSMWAVVKHLLPKSALERIAFIDSKESLAEVFELEKIPQAYGGDSPYTFSPSNNPIYTYYSHHSSHSFLACVSRSPSCTSIADVYYTAHNTPFQSRRTSPLISRQNSASGGVMKAGFRAGYGTDLRMTKNIDERSQKVEGDDNDDDEDGMTTVVSSPDVAAVRPMTGLVVQPLTEREDPRPTLSRASSTLTSRSKSSARVYSSPAVSRIKSLSDFHLYLSPSRLARIDILSDSSDSEDEVLSPPSIPLPPRKVLRPALLEKSLAGTPDQREKRANRPALRLMGLPGHLADDDPVRSYSGRLQMHHAKWLEGWKGTPEELGLEDNYKGGGVVHGEEENAPMPRTISVSPPIDRPPSPSGTLEPSPSPSPIHSPTLTPQPHDIQPYSTSNPFFGYPVVQSGNSIRPRYPRNRKRDLIKTLLFLFMLKLQSWRDSVERALGLNRLRIPSLSQPYCTSSLYTPGPNRRNPAEGLVRSAATPHTYFKQVARNRRWDKDWWWMIIGMLLLRGTWGRIVLAPLEALGLGLSEWKAMWGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL36</accession>
    <name>A0ABR3BL36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611873.1">
        <property type="nucleotide sequence ID" value="XM_066759927.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992327"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045713124" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="28"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0243506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="213" mass="24555" checksum="9634944EFFEAA827" modified="2025-10-08" version="1">MRISQTLLALPLLSVANALHFYFESNEKRCFLEELPSQTIVEGHYKAFLWNENEKQWKKDEAMGIHVAVEELATSHIVVDTRGPPEGRFTFTSHEPGDHNICLHSNITGGWLSNEHIKMYLDLNVGSSRFDNAADQTHVTTLSSKIRELNSKVADIQREQRYMREVEANFRDASESTNARAVWWSLLQIAVLIGAAVWQMRHLKVYFEDKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL73</accession>
    <name>A0ABR3BL73_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611906.1">
        <property type="nucleotide sequence ID" value="XM_066759960.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992360"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0243539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="172" mass="20313" checksum="2A7FA69873FB5D7A" modified="2025-10-08" version="1">MARFTEYSVVGRTLPTEADPAPKLYRMRIFAPNEVVAKSRYWYYLRQLKKAKKAHGEIVALNVIHEKKPLKVKNFAIWLRYDSRSGTHNMVKEFRALSRAEAVEAMYQDMAARHRARFRNVQILRVAEVEKKDDIRRPYIKQLLEPGLKFPLPHRRTKSKAWYAANRPSTWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL85</accession>
    <name>A0ABR3BL85_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610713.1">
        <property type="nucleotide sequence ID" value="XM_066761173.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993607"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="576"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="839"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="387"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
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        <location>
            <begin position="742"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="956" mass="106585" checksum="03B7657F8ADD3284" modified="2025-10-08" version="1">MARQSKPFTASTVSQEKPKKQVIKKKKLDPANAYTYLPSLPKRHRTSAFQNSLSYEELQQAKESSKGRHYDEDDEESMQERVRKVAMMIASEGPQEVDSEESEVDSDEAWESDGSDEERWGDVFKELEKGKGKKKAKDVVRKPAKPLTVNLDESDGEAPKKTAKKSSAPTPPESAEEDEDDDDDEDEDEGEEENEDEEMSDEEDDSEDDDEDEDELLELSDEDEDPDTLADLDAFVDQLAASDKKRKATETDNDSSAEQKKRRVLPVKSRQEIKDDTALKSNQKLDISALISSHPSLASASALIKPTKPSSTKSILKGGVLAAPLPTVQQERLDREAAYAQTKTEGQKWSSLMKRVKEAEHLSFPLQAKERGGVKSANEILAGFKPQNEMESAVQALLNKANLTEDELTKHEDLQMEAREMTEEEIKARRAELRYQRELLFRAEAKAKRVAKIKSKTFRKLARKRAAKENPEMALEDLERLDPEAAQIEREKIERERAIERATLRHGAKNRWARGVGGEADEDERMAKEAMLDMKEKLLRKIQGKDEGSSSEEESEDEDEDEEIVKAKAFDQLAQLSADSSTASQAQGKKGLMQMKFMQKAQERRMKEVAEQEKDARMQIELFGEDGEREEESGSESDEEPAVVNVGGNEGRLKFTGPTPGTNPPESPALPTSSGQDPTPAPKPKSIFARVPSSPTEESNPWLTSTSSSGPSRKRHAQLGSQLSNETKAVKSIKKASKRREDEEEDEKVDIDVEAPIASKSMEISSKMGKAKSKAPAAAVTAQTAQAEEQEEDEEITDLLPASGVKAFKQRDLVAEAFAGDNVVEDFAAEKARQIEADAPKVEDTSLPGWGSWGGKGAKKRKTNPKFLVKTAGIEPTARKDFAHSNVIITEKKDRKASQFQLKDLPYPYTSKEQYEKSFEVPVGNEWNSRSGFQRGTLPRVVKKPGAIIEPVRRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL93</accession>
    <name>A0ABR3BL93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">STB6-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611921.1">
        <property type="nucleotide sequence ID" value="XM_066759975.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992375"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="3">
        <location>
            <begin position="67"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="800"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="636"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0243554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="921" mass="101751" checksum="59C3BC61280B50F4" modified="2025-10-08" version="1">MSYVLSPSTLFPASHANTPTTPCLSPSPSPNAEHLLRPSSNGLLIPTDRTQDVLETKWLGMLGRLRVEREVILKGYALYSLRTWTHFAHTIVTQTGKPNDQISAYLLVPSAELSESEGDEEVANAIQFLSSETRSQPRRTELGFLLVTSPSAFGQDVNPVPGGDFRVAKSYIVVNTALRRLGCGGRAVLGLEPPIAALRRKFHDLYRVPVPVHSGPMHVRNSSPSASPTRTPSISGSPHDLHSIHPLAFPPSSARSPVANGHDINSDPFTYLVIELVKLIQAALALWGMFQHVGEDIHGRLISLGMEVDGLFCDETKSAIFRWRREMGMEYEGSLKIEKETSGGCIDPKTLASLLSSITSVHYQLDALDVERGDHLRVQRLLTGVAQTASHLSANLKGGGGEETSLRWREHQHRHRLDEQQLEDPGMVMIIPDDEIGSIAPPDAITTHLEAYIKCILKSKEKEWDVMGARRIAELWNGSLADSVEGRRKRRGTLTLSLGRGGSRERGKGVLRKRTSSRDDTMREEEGREEGDLRGTIKEISERAGQALRGGMGIMSRKGIADETSDSETGGPGPSSQLAALIRKKHGPVPTVIEPDAVDENHPEPPSVSPSTSSRQLPSQLAPSPFSIPSKPNLLSHTSRTPSRTPSGRPPTIIIPSGNESEVWSRVSGYPGKSPGEERSDLDLGYSHVKNNKIGSVAGRGTSNAVSKPASERAIAWRNKGRSTVMLRSSSDGADVALDETGMEWEVRNPHGTGKREGEAAKLVARRHSFNDLDDYKGARMLSPQHLQIDVEMCLVALKLRQKERQLAQKVKDVKLLEEAVYTAASQLGMASRARHAHIETLKSQAEILCASLEALKTEEDLEEQLPYDRFHYYLSEETHRAELLDDLGRLKEMWENVRKEGDERRRKLEKKDAKKTWWFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM09</accession>
    <name>A0ABR3BM09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612203.1">
        <property type="nucleotide sequence ID" value="XM_066759556.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991954"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09257">
        <property type="entry name" value="AP_muniscins_like_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="2">
        <location>
            <begin position="590"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="879" mass="92885" checksum="4ADAD9DBA8B969C1" modified="2025-10-08" version="1">MSDTLPDDAWVNAFLAAPPRPLLTALQKRLHTSTAHLGALADIYKQRAAVEAAYADGLQKLARTAEQGALTGKTGNDWPKSSGEGRLWDSVISELAEPIREIPTKVVAWRRIGDQDANLDKTLKDYEKVSAKLEKASSKAKSNKVDGLQSDLNNITQALSSLSPMVYTTYQRLDEERLRALKEIIVRWATVKGDMASRDGQRAEAIISHLLQWETSDEVMNVGRKLGGAGGARVPERSASVATSTATTPQSNRRLSTVTSTTAAHGDFSPRLPSSRPNGSSGNASQGTPTSSFTGGIKSMLGRSKTMGGGRNRGGSDATSTRSATRGENFEVIGEEEPPRMRKSSTAPPVDEEGFSVAPSDRHRNPWEDPNELIPTPAGQTLLQPQAPVVPTKDATPASAVPAPAFSQTFNASPNASDENLGTPTSSQSHQQQPRKNLSLAPVPIQESEEERQAALEKMQKTLQLPPSQPSRRSTIARGRRDVRNTMFAGSTDEASNAVFGAGAGAGLVDGVSKSAEPEEKLVDSPTFARSPIHAGAFAATNRDIPSPSPVVRRTSLSSVTSNNPFDSPSVGIGGTMTPPVTAVSSSSDQPGLRANMNESVNVIFRNKQIQRIQITGEIHLSLRLAAENSASSLGGGGPIHIRLAAFERLEKIAPNPAYLAQVPDKPGEYFLNSEVLAAATAKGAGAGAPTATASGGPLLFKYVVHVQPGKELATVPLILDPAFQCKSGETRMILHYAANPSSPIQVLPQGGKNAAGTVVAAFAPGGPNVINVQAKPAGGVWSPTTRRMTWKMDSLPSGSTDGSGKIIAKFTSEPGQEALVPQGVQMSWAVEGSLLSGLGLEVVDTTGGELEGNRHWAFEEIRKSTTTGKYFAEPVVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM15</accession>
    <name>A0ABR3BM15_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612199.1">
        <property type="nucleotide sequence ID" value="XM_066759552.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991950"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="673" mass="69774" checksum="4814E110E1E4BC52" modified="2025-10-08" version="1">MQDEQPPQGDTRMNEDAPMHTPTSPQGNISDESNHHPQSTFPLPLPRFATSTNAFGLVSSPSSSSSSQRSNDHLGSANGSSLGSIPGIAVAAASDRKVRRPSMLSLAQNASFLSEGSGDGETTPMAGVVDTAGEAEKRGAADMVEDPSSSKAINQFTGNNGPLQPTPRWPSSGSFQSSLLKRSTSTSTIRMETLKTSTPVQIELVGEEARRDSDSEMTTDWLKQSSNEKGKAREGSPSNHDTKLHPRPLPSALLQTLISESAPLEHEIQSEARLQRLLISHPAKLPLTPRAPRGSRGRFPDQVGGDDDDDDLGLSAFSAAARRWGTGRPWSKEDSDSDSDDGLAAGEVNAAFAAGMDMDRPGSSSSNANTVGTGWGAMSESGKSTPGQGERRRSDSGSRSGSGSAGAGAGTGTGYPFPNAMLTPGAGSQVQPQGQGQGQQPISAIKGSSRLSMSGMVSSPGNGLPTAFGGLGMGTGTPLASPTVERNELVGSPNAPMTSPGLMQYRESLGGSASIRPGKRKAQEDRFDPYKRPRAASPSLLSSPAFPLSPSRPTSIPIPASPSHAPLYPSALSTSHPRSVGGVGAPTHPSSSRPNHPYTRPMASRSRAASPALSVGSGGTSLGRERYLGQHVQNGTNGHGGQGALGGLGLLSLANKVREEDEKEERGEGMEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMC6</accession>
    <name>A0ABR3BMC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Allantoin permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106221</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611415.1">
        <property type="nucleotide sequence ID" value="XM_066760654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993076"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0242033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60392" checksum="4457F24679652FD1" modified="2025-10-08" version="1">MSIKFSKPDPKKWFTSEYWHLDTPPASYATHDGWSNADVDVVPMEQRNWRAVNYLFLWLADGANVGTMQQAASIISLGLSWREASVAIAIGNIIIAAAVTLNGVIGSRHHIPFSIASRASMGFYFSYFAVISRLVLGLLYFGINTFIGASCTLICLEAIWPQLKTYNNTIPASQGVTSNKMIAYFVFWAIQFPLVMIPPRKMRWLFFVKSIFAIIAAFATLGWAVKQAGGGGPIFQQHTALTGSARSWAWLAGINIAISGKTTLAINIPDLTRYARKTSDAYWQVIFIPVVYWVFSFIGLVIASAGQDIYGKLYWDPTSIVALWTSRAGAFFVAFAFGFATLGTNISTNSIATSNDFAFLAPKWLNIKRGAFITSLLGGWATCPWKIQASATSLTTFLSGYIIVLAPLAAIMIGDYWVVRKTRLHVPMLYQNEGIYKYTWGVNWRALVTLVIVIPINLPGLIHAINPKVPIGNFSYFYKASWLTSFFIAAGIYLILSSIFPPTSSLVDATVESMDEDISEPTADSKGWEMEKVRESDRSHPLVNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMF6</accession>
    <name>A0ABR3BMF6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612341.1">
        <property type="nucleotide sequence ID" value="XM_066759694.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992093"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="333" mass="37253" checksum="CE182DB6902450F9" modified="2025-10-08" version="1">MAPASHFTLNNGKKIPSIGLGTWQSETGQVAKAVESALKSGYRHIDCAWAYGNEKEVGEGLKASGVPREEIHITSKLFELHHHPEHVELACKDTLKNLGVEYLDLYLLHWNINFQVDAPKGTVPKWEHAVKADNGKIKLDVALADNVIPTWREMEKLVEKGLVKSIGISNFNIHRTEKLLKEAKIKPVADQVELSIQCPQPELVAYLKSKDILPQGYSPLGGTGKSNLRENDVVEKIAKKYGVQTANILLSWLVMRGINPVPKSVTPERIANNLKLVDLSPEDFKELEKLAESHPPNRVCDQSQDFEPKYDIFQENDPEFSDKAQFAKLGLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BND4</accession>
    <name>A0ABR3BND4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612657.1">
        <property type="nucleotide sequence ID" value="XM_066759170.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991561"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="1">
        <location>
            <begin position="430"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="533" mass="57999" checksum="410FC2726D408385" modified="2025-10-08" version="1">MRIPLDVAHSVVRALHAIRDDSGGNVTQTSVHVPGNQPAWAEWLSPNLAAFSIEMDRWPDWAGQKVGQPNQYVNQVLTNLGERTGVMPYLRVGANSEDRATIDLSFEVMNATFPAPTAEVPVPEADHIYIGRDFYALSGNLPPGTPFQWGINLASLDRNETIAQAKLVAEAFQGDRADLTASVWLDGLEIGNEPDYYGTGKPGIDATWTPANYTQTWVDYAHGVSEVIQLGGDGPHLTPGAMTGFNTPIWTPQATFEAGIVEDEGLRALIKQYNQHVYSGAFGYGYPLTPVGGLMDKSSVRANLTIRANEVKAVRSQGLSYVFAEGNSYGNHGQPGTSNTAEGALWALDWMLQLASMGIERMHFHHGVGFRYNLFQPVATDADHDDGTNMTQRAHILPAYHAALIVNEAIGTNGNSFVAEISTANDNVVAYGIWEDEDLVRMVVTNTEVYTTDDEESQKGRNKFEVNLLGAEGRNATVKRLFVPQTTAQHGITWAGQNFDTEDGKPTGQVTEESLDNGVLEIEASSAALICFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BND8</accession>
    <name>A0ABR3BND8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type ATPase assembly factor PKR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612665.1">
        <property type="nucleotide sequence ID" value="XM_066759178.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991569"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251:SF1">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13431" checksum="3B55F3B9B74D612D" modified="2025-10-08" version="1">MSEAATTHFVEDEPTKPQEEPGFVGLLVKSVFEPGANPAVVIAMNVCFFLLILTLFALAFLTQWNKHVLLLLGVTLLLWGSMAWFVLELTRVQNRPDNMPPLIDLDSFEDSPADESKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNF7</accession>
    <name>A0ABR3BNF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612511.1">
        <property type="nucleotide sequence ID" value="XM_066759024.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991407"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="75"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0245427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="512" mass="56694" checksum="E34A89CE1F307FD1" modified="2025-10-08" version="1">MASTPRDEVIIPSDVVSDKDMDFKEQVEHVEDRSGGNIPVQDGAIAAEIELLRLMSPEDFAIEERNLLRKIDFTLLPTLFILLILNYLDRNALASARVQGIEKSLGLVGTQFNSAISLLFVGYILGQIPSNMILSKTRPSIYLSVCVMVWAIVSLCTGFVKNYHQLLAVRILLGFTESPYFPGALFLLSTWYTKKELAYRTAFLYTGSLLSGAFSGLIAAGVQNGLDGKLGMESWRWLFILEGAITGFAALISIFVLPDYPSTTKWLSTREKAVAVYRMEKDGGSRDEDDQGLIHSLKLAICDYRLYLLATVIITKTTAGAVTQFFPTVIATFGFSKVITLVLLAPPYLVTTGLSLLISRLSDRKPERCFHLALPLTVGMIGYIIAVSTLKTGPRYFSLFLMLGGLFGSYNVALAWISSTFPRPRAKRAAAYAIINSLGNIAQIWSPYLYPKSDAPRYTTAFATNSAMAAVAILFCFVLRFFLKRGNEKMDREDAEAEARGEAVEERVRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNG3</accession>
    <name>A0ABR3BNG3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase GET3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612370.1">
        <property type="nucleotide sequence ID" value="XM_066759723.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992122"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="9">
        <location>
            <begin position="21"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0244003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="325" mass="36177" checksum="E1C0CFB70E16F364" modified="2025-10-08" version="1">MSDLEPLDPTLQNILDQKSLKWIFCGGKGGVGKTTTSCSLAVQLAACRESVLLISTDPAHNLSDAFSQKFGKDATKVNGFDNLYAMEIDPNGSLQEMIESSDQSGGMGGMMQDLAFAIPGVDEAMGFAEIMKHVKSMEFSVIVFDTAPTGHTLRFLSFPSVLEKALGKLSTLGGKFGPMIQQMQSMFGGGAPQEDMFAKLESMREIITEVNNQFKDPEKTTFVCVCISEFLSLYETERLIQELTSYEIDTHNIVVNQLLFPKAGDNCEQCSVRHNMQQKYLKEAYDLYEDEFHIVKLPLLTEEVRGVEKIKEFSKMLIQPYTPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNN6</accession>
    <name>A0ABR3BNN6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611598.1">
        <property type="nucleotide sequence ID" value="XM_066760294.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992700"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="743"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="949"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1031"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1127"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="968"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="995"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1151"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0242216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1167" mass="124763" checksum="3AEA3D2651EA63FB" modified="2025-10-08" version="1">MRRISPHPLRQRLAPRPSPARTLQTTTAVHFPRSPTPRRTFAAASLPAEPHPPPPPPPPPPPPAAAAAAAAAPAPTGLLSYTTEVVPPPPPAALPPDLRPALTHLATAFLPRNQHLAPDPVSSPFTHVISFPPAAHGRPQTEPSADAEDSGPLPENVLALASPFEGGDIYVQDAVQQLANQMDADVVRLDLVMGVALDGVAGPLGVYGPPPLSQSLNPLYQSAPSPFSGFRREAREAEDQEDGMGLGFTSMPVAVLGGGGLPIPHMGHVGPQEEDIVAGRASEEWVSFFSRIINADTAEAGKKRIVVLESPLAMSKTFPVWWPSLVEAVQRRRRGLITPGRKKMVPKNGSVEPSLVHPTSIVLQCTPSPLLPHTSPSMFAPTEKEDHELAAEEHVDEVDEQEEATHAAISALEDKFRSMGFNVHHHVEVVKPRSGAKLWWGNEESDPAGRREGDQSRLKAILGKGLASVLPPFDQSSDSGNQPRNPLQRLLMTRLAHLHPRSDQTESSGSAPLVWKAFPIVPLHRNFDAEKESRTLRRRIYSAALITRAVYQLGGELQDPLGVLKLSESTGKPLTRKTGPSSVAKGYGNTVVSWSDALHIASIAVGRAVQTGQVDGDAAIVHWADIVAARQAAVEEKSMTADHLSKHIPSASLKDTPPKTTTTTEIKEEGIVDPVVEKIRKDKKLSQHEKRLLNCIVDPSKLASTTFRDVHLPEKTIDGIRSMISLPLLFPEAFRGGVLKDHATTGALLFGPPGTGKTLLARAVAAESGARMLAIQPSDVNDMYVGEGEKLVKAVFSLARRLSPCVVFLDEVDALFGARISRGSSGSMSHNLILTEFMQEMDGLSSAIANKDKRVVVIGATNRPFDLDDAVMRRLPRRLLVDLPDVQDRKAILEILLRGEQLGEDVHLDQIAKETDGFSGSDLKHLCVSAALSAVKDTVNVPWRHLSPLPAASSSSASEQRPRTPLPGAGGGAGRGGGGRGGGGLGNEVLVMAPGEGGSGGGGGGGGGGRKKVRVKKEKASATAAQLIVSTAREAPASDTPAPDEEQQLGTSETPERVEQEQLLSADRTLDTSPIEDTPEPAKAPMQEEETIPKRVLMQKHFKIALEEIRPSASEEGSLPELRKWAEQFGEGGKRRGKKSGFGKGFGFSDEPVKDRDTGYGKVKQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP13</accession>
    <name>A0ABR3BP13_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="6">PME-1</shortName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Demethylates proteins that have been reversibly carboxymethylated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612889.1">
        <property type="nucleotide sequence ID" value="XM_066759402.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991797"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="125"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0245805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="424" mass="46214" checksum="18C004620E58D3F1" modified="2025-10-08" version="1">MSDMFRKSMLNKLPQLPPTRAPWADEPDVEDIDEEDEENEQGDAIGELGPVTMGPSKHNTQDYSPLSASTFFAQAAEVQPPSTPCTFRVYLTPPNLPTTSATAGTLPGPSGMRTQQQTNKHGTYLVCHHGGGASGLGFAPLAREVKAKGNGEMGVLAFDCRGHGKTSTRDPKLELDLSHDTLLSDFMALIEMVFPNPKESPSLILLGHSMGAAPVVSAAPELQKKGYIIPGVVVLDVVEGTAVESLPAMKSILSKRPESFRSVIDAIYWHVSSNCIRNVESARVSVPHIIVPAPMSPSSGPAASPGYKQVWRTNLLRTERYWEGWYKGLSERFLRAKCARLLVLAGEERLDRELMVGQMQGKFQLEVMSDVGHYLHEDNPARLAALLITFWRRNTRVLVLPPKIGTAGSGDRSGPVEVKQVGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP37</accession>
    <name>A0ABR3BP37_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612751.1">
        <property type="nucleotide sequence ID" value="XM_066759264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991657"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0245667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18455" checksum="1FC61576255AED65" modified="2025-10-08" version="1">MAESSNIIFDDRFTVDTVDKDGKKFDRVSRITATSHSLSMSLTLDIANELYPLEPSETFTLTLARSLVPSELEALDNADGDEGEDGNEVRRVKRELWRSNEQGLAEDYDYVMYGKIYKFDDSAQGEAQTTAYFSFGGLLMALRGSYRHLAGVVVGENIYLLMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPA7</accession>
    <name>A0ABR3BPA7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0246998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612959.1">
        <property type="nucleotide sequence ID" value="XM_066758511.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990886"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="526"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="526"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="426"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="611"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0246998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="729" mass="79186" checksum="2D4CC96E49E63F65" modified="2025-10-08" version="1">MSPNTTSSSSTLNYPPSFDPHHTSSRYPLATHFAPYSPYRPGEYGRSERGLASERTRIERKLFADGQEEDGEARKARGSSPLAPAFEAKMVLRNGASIDLISWLRTNFHHVPPPHTPLVPSMPLNGIRHLILERFPRAPEAQEIHKAVLAAFPHSQWDYPPPESSEPPTIRGLIWHGKDIVNDDEVEDRPRSTPKDVATHNARGRVSGGIITSANSNPTLKGKQSSRSPTQSTLVSPISSSKRHLPDTPARSVLEEFAEIATLAEKTPVSRTKSLPGEPLVTSPEQEVAHLSHNPFEQSMLLRGRGKRRASQSPERGHRRRASTPDKLHGLLAAAEAVEGSPITSVLGHKRRRTIGGPVPARELMTFPRRAMSSRGTMSPPPTRGLAMLPHVEENIDYLVPLNDTASAGSRISEEDAASNALPSIAGASTARRAPTSSSTASQSSAISHHLASAPVAGSSGSMHSYPLDHIRDHGLSLSHAHHHSSSQTQSYPLNLPRVHAPRTGGGGRKVNELPTEGERPGYDCKPPYPYHEMIRHAIENAPDRKLQLNQIYASIAERFPFFKTLDEKKTAGWQNSIRHNLSLKKMFVRVNKVDGIPDDSGGKGGWWTVIPGVPDEGRPGRKAKARKAKLEKEAASKEAASRVGKENDARGLGMGGVLPTPDGHAVPPVSSGTGSGLDQNYNGHGHGHDYGQGLGSGHGQGQGALHEKWVEENRVQEESVDELEDDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPC7</accession>
    <name>A0ABR3BPC7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612459.1">
        <property type="nucleotide sequence ID" value="XM_066758972.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991354"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0245375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="862" mass="95090" checksum="2F44BF8947906EF2" modified="2025-10-08" version="1">MAVRSDQQTSAEIQTGNGHENVGMRLPHTPGQQHLESVPIAATSRAPASSSSIKIAACLACRAIKGKCETPDGVGPCVRCARRRQQCERPIIHRSGRPKGSKNRHSSLERAFKVIERGVHQSPAQSRKRPRLDRDGQDNSEGSHIYDQSGLAQSPITQPATSPQQPPYRRLPESSFCPAPFDFPALDAVEPQRPSSSTASLSITPYTNQQQPVIPMSARSYDSHQSSHPGGEMTREHDDGLSNPVRLLAEAAEEIGASEQSGHFSERTIQAATTQEPILPPEYNLPETLYAMLTDGEMDPISNTSGLSPEYLAQGLEILLSDGARRKLSDEDRVFFNPPLKEVKRDIGDEYCPLALALLTPREVKAFFATFYLKLHPMLPVLDPVVHTPEFVQSRSAFLFTAICAHGASLTAGAEEATKRLRIHTQRLADQISPRGFISVEIVKAFLIWISWLPSSVPFQEERLWHETKYAINMGLELELSKPLPSDLRDLRKDPSWTACLEGISMDDWDVVERIIRSRQRLWIHLFLWDSSLNLAFGKATRFTQDHLIRDETWCFHRLATKGDAVTTACVNLRRLSVCSVVRHASVGATHPREHDFGMGGRKNRRGAESLACILVPALRWVSVSGASISAHTAVDAQLRPSGAHVAIGVCRGSHKGYLFGGVAQLRVSLRAAAGFEGIMGKAHLLSSYEFVMLTYGQGFPNTMGPMLSFEALLAIRLLPQDAGTTLAFRARLFGVLSQLSLLLEQVGTTPSHRLGTAAVYGRHLQVYIRRRVIDLCVNHHQYETGQLHGDGSDHTAASSGSQAPLMREAEASINQLFSSDWISPTDQAQANMTLDGINTLNFFDTTAGWTDDFFRLFGKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPF4</accession>
    <name>A0ABR3BPF4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613040.1">
        <property type="nucleotide sequence ID" value="XM_066758592.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990970"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="415" mass="46696" checksum="4AEB063C15542432" modified="2025-10-08" version="1">MSWRTSPAHSYKFPTTISLRATLTAPQLATDARDKDLSQFFETPGLSSKEVSDVLQEFVLHSIRRGKRVREWCKEVSLAFSRAHSLPAICDALTTPLLSTLLPFTRLPANSYFPTPEPPLPTSLLPNSLLSALTRNQLIDALVRLGKDDRLISNRIHYGQELVLELCLEYIGRRWRSSEAVAENVVDDISRKLTKIEFETRIRGYPPVVRTIISPILHKVRFVLGFIISSQLVTRLNSSDRSTYLHSGSRPYQNITSWIERRLQAGMVYPLILEECKTMKQEVNDENGDTIMDVLEQFGLAQSFISGNYSSYHLVRKSLHSPSLRPKLSPKCFSHKRAHSSLSKVDCPNPYQQPSLSAIHSHNGAATLSHIPYSNSSHSSSSSSLAPGDDVYAFLGCANISEARSILFWRLLDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPF9</accession>
    <name>A0ABR3BPF9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613043.1">
        <property type="nucleotide sequence ID" value="XM_066758595.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990973"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="70"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0247082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="225" mass="24567" checksum="5F355A291400EDD6" modified="2025-10-08" version="1">MYSQALDSAKVAFIEAAIEHGVLLFGNFTLKSGRQSPYFFNAGLLYSSSLLSTTAQAYAKILSSSRIPDFDVLFGPAYKGISLAAVSAVSLYQQTGKDIGYCYNRKEKKDHGEGGTMVGAPLKGRIVIIDDVLTSGKAIREAIDILKASPEAKLVGIVQLVDRQEKGQSGSGKSTVQEVEEEFGVPVEPIIGLDDIVKYLESSGKWEKELQEVRKYREEYGVQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPH7</accession>
    <name>A0ABR3BPH7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613054.1">
        <property type="nucleotide sequence ID" value="XM_066758606.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990984"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF6">
        <property type="entry name" value="INTERSECTIN-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="409"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="629"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="11"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="285"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="725" mass="79679" checksum="0FC252C595D72FDC" modified="2025-10-08" version="1">MGLIGIIANKASSVSAQGAQGERDENSGISPEPAAPTDAEPQSMSTIPEVTKPMEQLAQGYQDAEIPDSLQPTEDSRRLSAHNIPSLLRTRPRAISTLSVASTAMSHTPSFITDNEEDEAEFSSDDSILSFWSSDESSSESEDESEAEAEPPVGDKMTDVEQPKKERRAAPKPPKKETDAERETERKKREEQRQAILAAAGLQLKREPSGAPMQRLGRVASRRRPAPNVPGRKRRHAPAVPESKRKELPSPPTKELQPDRLGTQDAYARYEAFLAQSALVQSQPLPRPEPVRAESQVLSPQLTGPAGGAPLSPASTTTSLPTSTLSLGKETGGKITGFLRSMMTPHGHEPKRPSISGPTITRVDERPVSPAPGLGILGSGEEVDAGFGKTWSSLVGPSVLETMDKKERKRQEAIFEFIATEISYNRDLQLIVEVFYASLLSLLDEKALTVIFANIEDILLFNTGFLSALEERQKAARLYIDRIGDVLSFLNEAGVYMTYCVNQHQAIKLLQSLREEKPELDAHLRHIQATNSSIRGLDLSHYLLIPMQRITRYPLLIKQIIAYTPYDSSDLTPLQSALHAVEGIVSRINESVREAEGQERLRVLSANLWIGGEGRLDLTAPTAFLGPRKLIKEGPIFKAKSGRKLSLVLCNDIIVLLEDNSLYRMPLALHEVEVRQTKDSMGFALKADQRRGGDTIALKAASASDAKDWMGKIDKARRRVLATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPQ3</accession>
    <name>A0ABR3BPQ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613131.1">
        <property type="nucleotide sequence ID" value="XM_066758683.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991061"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31213" checksum="D91FE6B31BD0D5FB" modified="2025-10-08" version="1">MSDGSKYYHPPTMEDDLASTLKLHDNYSQGDIQLLSADSVLFITYAWRLARVSAVFRDMMEVSRPSAVVDSSFNSSGLSTTNNKDPIEISHTSTLLERFLDIISLSGQNMIEVPYEEAAGMFDLCDQFDFDKKIVDKIRRQVVKQGRSNPWELLILGSKLDDKTMGLQALRMMDHDVFIKGKPGHKFWATMEELENGWRPKLFDLVFKDPGEIASAPEFSGHDISRSSTVGPQHASRPLPVSYRGSYNPGRSGSSATVLLFKDNNWASVCERFLFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPR3</accession>
    <name>A0ABR3BPR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Splicing factor 3B subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104642</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612594.1">
        <property type="nucleotide sequence ID" value="XM_066759107.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991498"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="11">
        <location>
            <begin position="170"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="532"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="12">
        <location>
            <begin position="932"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0245510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1154" mass="129924" checksum="887C14928C007B61" modified="2025-10-08" version="1">MSDEGYPQLQSYTAPQEILDEHAELADEDDTPDAFQDKAKSKQVAARQSDYHLRRFNRTDGQGEGEDESYEERMRRINLEKEEEKVRRYKEKMEKEEKERGEMQVDDKTPPRELRGDETPPRKALIGDETPPRAQAGDATPPRKKRRWDSEPEIKQEVKEEVKEEVKEEEPKKRRSRWDQTPAEAPPEKKRSRWDQTPAQTASTSVLAAPTNLAKPSGIVLVEDKRYRRMTDEELDSLLPGSEEGYVVVPVPHDYHPAPSVRKMVPQQAEAGFMMQDETEAARARAAAGGLQGTTEQTEIDGIGTLQFLKPEDTQYFAKVLGEGGGEENDAEYTLEELKERKIMRLLLKIKNGTPPVRKTALRQITDRAREFGAGPLFDKILPLLMERTLEDQERHLLVKVIDRVLYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLAHMISTMRPDIDHVDEYVRNTTARAFSVVASALGIPALLPFLRAVCRSKKSWQARHTGIRIIQQIAIMSGCAVLPHLRNLVDAIADGLKDEQQKVRTMTALALAGLAEAAAPYGIESFDNVLKPLWLGIRQHRGKTLAAFLKAIGYIIPLMDPEYAGYYVRECMPILIREFQTSDEEMRRIVLQVIKQCASTEGVTPSYIKEEVLPEFFKAFWVRRMALDKRNYKQLVETTVELANKAGVAEIVGRTVNDLKDESEPFRKMVMETITKVVSNIGAADIDERLEVLLIDGIIYSFQEQTFEDTVMLDGFATVVASLGPRVKPYLPQIVSMILWRLTNKSAKVRMLAADLTTKLAPIIKSCKEDVLLSKLGVVIFEQLGEEYPDALGSLIAAEGAIANVVGMTEMNPPVKDLLPRMTPILRNRHEKVQEATINLIGRIADRGAEYVPAKEWMRICFELLDLLKAHKRAIRRAAVNSFGYIAKAIGPQDVLSVLLTNLKVQERQSRVCSTVAIAIVAETCGPFTCIPAILNEYRTPELNVRNGCLKALAFVFEYVGEMSKDYIHSVVGLLEDALTDRDHVHRQTACAIVKHLAIGVAGLGYEEALTHLLNLVWPNIFETSPHVIGGVMDAIEAMRLGIGSGVVLSYVLQGLFHPARRVREVYWRMYNTLILGSSDAMVPFYPALGSESDLASGQDYTRHQLMMWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPZ5</accession>
    <name>A0ABR3BPZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613221.1">
        <property type="nucleotide sequence ID" value="XM_066758773.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991151"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="278" mass="31006" checksum="3157377F0084BD4B" modified="2025-10-08" version="1">MFASPKSICTSKSINLFPDELCKTAQGDELTWLGDSTFHRPPIAFIPSPLQISVKLFDRLAYGNPSYSIGRSSPPNQWDSPTDILFYHHRLSEHSPSRDTSEGDSMATWTTQSYTATLHQAKIETLMRKERAGLFQIQTIQGSQNMLELFPYTPTILPMKHSAESSTVKDGGDQETKGSDLLIPVLDSPMTPGGFQETKNGTGLLANRIAITNRLRLKESYSTEADEDTLIVFYDRQPSHGFNELQVDEKTTPGEKDFMKALVERTGRAAKKARMANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ03</accession>
    <name>A0ABR3BQ03_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613214.1">
        <property type="nucleotide sequence ID" value="XM_066758766.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991144"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15314">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15314:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="245" mass="27101" checksum="D07122ACA135FD09" modified="2025-10-08" version="1">MSSAVKKLPPPVPPKQRSSAHPSAWTHPSHKAPTVPLKPLQGVTKTRGDAGKAGHGRECIFVTRKTALGALMGRCRSLVVDEGYTSLTLYALGPAISHALLLLHALLDLLPYPKGEKGMWYEIRTGSVECIDEVGKMKDGQTDDNNAVEKEDAWLNDVGSVEANVPERATRVKSSIEITIHIAPRPASKSLSTSKEKKKKNRPSKKTRLARWNRLKEEERLREEEEEEEEELEEVEGDEEAAINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQA4</accession>
    <name>A0ABR3BQA4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612420.1">
        <property type="nucleotide sequence ID" value="XM_066759773.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992172"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0244053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31761" checksum="00AF67906A4A53E3" modified="2025-10-08" version="1">MLLYLVRHGKTSLTSNNSNLVQGTIDAPLSPGGYTQAQKLAEHLRLVPFTEAWTSPLAAAQETANVILSQQPSGKAQLHVDDRLGAKCMGITESKHCGEVNGDLVAHKAEDGDTVKARLHEWLTELLNTHTPSVSTPQSPTSPFPPLSPLSCTLPRSPASTGNFTPSDLIRALPRPGFPRRPSSRSSSGATGLGGGSGSGVILVLTHQECLEKLFEMLNVDESVDEGDESEGKVKKVPLSMYVTEGIDMENSSLGNTSVAILRVWWERVESDEEMGSVLEARGRLEAWGMKDHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQC2</accession>
    <name>A0ABR3BQC2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-hydroxyisobutyrate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612183.1">
        <property type="nucleotide sequence ID" value="XM_066759536.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991934"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="180"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="1">
        <location>
            <begin position="354"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="476"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="63661" checksum="FD08608FF524652C" modified="2025-10-08" version="1">MTCEQKPVVGWIGLGAMGSGMAASLVSQGYKVKAYDVYPPSLKRVAEQGAISSSSPRDAAKGVQVLCLMVVNAQQVEETLFGKDVGVAEILENGASIIVFSTVPPSFLVKVAERLDKLGKNIGLVDSPVSGGSTRAAQGQLAIMSSGTPSSIATARSVLDSLTLPPQGGLTLVGERVGIASDFKMINQVFCAVSIAAQGEALGLAKALGLNVRTVYEIIKQTTGDSFMFGHRAPWSIRPDPTPKSAMTIINKDIAIVMGEARRDHFPAPLSAAAEQLYTAALAVGLEKEEDGLVSKFWEKLGGEPIAEQGTEEEEIEKARELVVKPGKKVRKVLLATRNADSRISSLKEVLKKAGMEVVEQGKDADAVIVSDRSAAAVEEVLANILSAGLSEGTPVILTSNVLPSSRLLQLAAEIKPLQLIDAPTAGGYKEAKGGSLTVFASGETDALSASHSVLSALSTQGGNATNLHFIGGGAGSATKVKAVNSLLEAIHLAVTGEGFAFAKHKKMDIERVFKVLSGGAARSFIMSDRFPRIISGASQDEPENTVSALWNDLSITLAEAKQHKCPFFLTQAAMQQLERLYGCGYADADDSSIIKLWEETGVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQD0</accession>
    <name>A0ABR3BQD0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trehalase</fullName>
            <ecNumber evidence="2">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613357.1">
        <property type="nucleotide sequence ID" value="XM_066758909.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991288"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="778"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="778"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="816" mass="89324" checksum="7F03A0A9708C2E69" modified="2025-10-08" version="1">MNMPPGTPAFLLESPGNFFGGNDDLRAASGYTLSGQPRIYPICFHFPPFDFQPAMSLLFSWAALFLLSLTAAQNITQTTSFSFSPTPVSTSVPSPTAPLDSIVPGQGNYPPVQGLCAGGANVPFCPGILLQDVQLSGIFSDSKTFVDKPTVGTVNETLSAWDALGGNVTVGEVETFVEQYFKGEGLELSQVQLQNFVEDPAILSNIADPVFKAWVKVVNGYWTLLARETNQSALCNGNCVSSLIPLNHSMIVPGGRYREIYYWDSFWVLEGLLKSELYDYAWDLLQNFMDLIDIYGFLPNGGRKYYLNRSQPPVFVQMIDAYIKTTNNVTILERALPVASAELQWWANNRTSNFTSPFTNQSRIITQYSVTNSAPRPEGYAEDFETVMGASPALSETEQAELYSQLATGAESGWDYSSRWCEQPLLNTTDNNPALRTLNIKSIIPVDLLSLMAGDHALLANMYELYANSTGGEKYTDNEKKPKRDGQSGYDTASKVAYHRQMAQEYRDSILDLCWDSEKSWFYDFNMTSSSRSDVFHPGGAWPLWQNITPSEIAGNESAALSFVSGFRFLLGHYSGVPSVATLLFTGLNWDFPNAWPPHAYTSIKAFETLGRMLPNATVLSNLTIPFDSVTKNQLGLSESELQPQPQSTVGNVSLNTETSQDKPWPLALSIEFANRYLDAAFCSWYSTGGEISGLLTQLPLSDLNATGTYTAGQAGVMFEKFNVTDTDAAGGGGEYTVQIGFGWTNGVALWAAGEYGQYIPAPTCPLIPILEVNATSGSNTSDNSVYNATDEDRGPTASDTAKSASLFVGYRIPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQE0</accession>
    <name>A0ABR3BQE0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613075.1">
        <property type="nucleotide sequence ID" value="XM_066758627.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991005"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="132" mass="15243" checksum="EF88E530EC20B076" modified="2025-10-08" version="1">MGRTYRIYLAGEAVLMCRHCGNHLAVSEGIISKQFTGQHGRAILVHTVVNTYSGEAEDREMRTGRHTVRDIYCQVCHTTLGWKYDFASEQDQKYKEGKYILEREMISEKPERRDIISGKPRIEEIPAREILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQK4</accession>
    <name>A0ABR3BQK4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613093.1">
        <property type="nucleotide sequence ID" value="XM_066758645.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991023"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="74"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="188" mass="21067" checksum="869FF4F2F9F2D8E5" modified="2025-10-08" version="1">MSQITDFFWQPFSSGALKLLPKRDVGIRAKSKRADRIPDDPQRPLVTDYHSINDPTMRVRVPKKTPTPVKVEAKVWFANERTFISYLSMGLLLSTIASGLLFGSRDSPASSAGVLIYGWAIFQKRVTMISARDSGNFDLLWGPIFICLALFIAILANFIFRLHEAKKHTGINPLSFTYAWNEAGTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQM5</accession>
    <name>A0ABR3BQM5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Expansin-like EG45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612540.1">
        <property type="nucleotide sequence ID" value="XM_066759053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991439"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0245456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="36147" checksum="9E5CEABE58BC82C2" modified="2025-10-08" version="1">MGNTAWRNFYPFTSLVVASMALTLPATAGSIFTRSNVAMTFYYDVSEGTSSSEACGSSADDPVPSGWATSSGINGGVPYCERSRGYSLEKIGTNNIVAFNSALVAADPAQWCGREVKIYNADGSEFTYSGGNLYIWDGCDACSSSDSGILDLSAPTFVALKGGTCAGNNPTGLTYEVLDNYIINPSVGLGAGFSKGAGSDDTKAGSTAVAASSSPVAVTSATRAVITSAQPVAVTSAQQAVTSPELAATTDTAVRSSFRYSFSTVVQDADISPSATSDIVLVAVQSPGCTESSAVDAAETSRTSTCTFGAWQCSGLELQVCNYLTVDSLGWETIEACRTSCSFTVSGSVDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQS2</accession>
    <name>A0ABR3BQS2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103616</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613507.1">
        <property type="nucleotide sequence ID" value="XM_066758105.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990472"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="463" mass="51619" checksum="2A917A01C955B5BD" modified="2025-10-08" version="1">MSSRPDSVRGLYTEEWVFLPPTVSPPPPTSSPPTHLPTPFNPDDSQLGDDLVLPLMGRPFNLFLSEYLTTAMGMPFEVGKTLLQVEYRPKRRFEPLEEADQGVKIELEKFKEKFKEEDELSNPEEAEMYFTDRLAQSSEPVVPATEQVLETDAAGYLADLHPTWLLKDDPDVSRGNGVWGMIRRIRYTPSEGLPALWKSQLVSTLHSFFSTLLQPSVHSFLQILTPYPPLSLDTPLTAFPNPSLPLGIQVASHLLTHLVLSPLEIIRTRLIVMPVSHPSTPSSIAIFREMINEEGGFVNMYLHPNVLFPALLEHTLRPLFALSTPLLLERYLGISPDISPITYSLADLSLGLAHLLILLPIETIRRRLQLQSRAPGGGKRMKTVVKVRERDYVGIVEGLWRIVTEETGVRRTRIEKGEEGGWFAGVRQLYRGFGMAATAHATVFGLGLVSATLSGGDGGWKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQV8</accession>
    <name>A0ABR3BQV8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchor transamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613535.1">
        <property type="nucleotide sequence ID" value="XM_066758133.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990502"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047209471" description="GPI-anchor transamidase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="46751" checksum="3BE8F0EC65D55A5F" modified="2025-10-08" version="1">MRLLHILTAVSLLLAPLISSLSHEQFDPQLSNLFGNDTTTDGHTNNWAVLVCSSRYWFNYRHMANTLAMYRTLKRLGLPDSNIILMLADDVACNARNAFPATVYANAGKMLDLYGEGIEVDYKGYEVTVESFLRLLTGRHEATVPRSKRLLSDASSNVFIYMTGHGGNEFLKFQDNEEVSAYDVADAIEQMWEKRRYNKLLYVIDTCQANTMYSKFYSPEIIATGSSSLGESSYSHHNDMDIGVAVIDSFTHNILQYLETVGKTSRNSLQEFFSTYDPAKILSHPGISTSLSNVPPERILITDFFGAVARVEVSPQSAELRLESRLIASKDGWEPTNLGIDDGSITEEIPEVLPRKMEEVKKGSGEWNQPLVIKTSEWGFLLPYLIGVVSFIWLYISLGDKEDKDDRQEVSEKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQX2</accession>
    <name>A0ABR3BQX2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613550.1">
        <property type="nucleotide sequence ID" value="XM_066758148.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990519"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="715"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="602"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="432"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="679"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="982" mass="109779" checksum="0A858FBBF4F81FBB" modified="2025-10-08" version="1">MDRLHRTRSQHFVSSPRKTASPLITRHTLYPRHPPKKRRLGVTTFAASCNEAGPSYTSVLEDDPEKAVMKMGESSSALAGKTSRSRTQSRPARRKSDGKIWADSLPNGKDGEDGASPKKRKRSRAGSLSTEDSWVETSGDEWEPDFIAESDRNLINYAPSTTLHRLRKAELVRLWKVAGMWDNEDIPDDTNEDEMAGDMGKKELVDGLIAARIHQTGRLISPLPSSPNRRIRRQSTLSPIPATPPPSSPLAKSSSPGATPKPRPRTRSRVRLETPLVRRQPRPSRPTRTLTKRHTKSEARSRRIRSQLAKKVNGKSENGDESELTELSDSDNGANGVEHTPIVKRLRPRGVRGAGSFMKEPSTDVTDFEDDAEEADAEATEVEEEPQPKERKSRSKSISQANLSKYDGDVDMAPASEQRSSKGLPTRGAKKKAIERMQGIERGREDEDIQMDKEGDIEMEKGTPTPQPATPPRRGLPSHPSTPKLDQDSTMVDSPTLSVATETETTTPRPVHTTRSGKAFGAIQNRRLQLLQEAWNDPDMDDEDGSDEEDGELEPDIDLSEATMASLIRLLRDELVQMCEARGIEVGGTKPQLAKALLEWRDEQKGSYPSSTSTARPSPPRTAMPRRKSKSKSRARSKFKSNKHVPAIGTAAHAPGKPTPVLLRSHIHANDPETPPLSKGEEGDVEEEKKGTEAELNLDLQELGLEDSVIKPSQLTKLEKIGSGGFKDVYVGKFRGRKVAISEFRSHLSEMDIRELKLLAEFSHPNIVRFRGICIPEDSTHVPCMLVSELCENGDLFDYIRNVPCPTLKRLLSLMLDIARGLEYLHTRKPSIIHRDCKSSNILINRSGVAKVGDFGLARVKNSTRSMIRSLVGTVNWQAPELWHPTPRYDYKVDVFSAGMVYWEMMSGWIGEKKYPWEGHNEHYIYDAVGTKHRRPPVTGMRKHWGSEPVNLMERMWHQDPAERPTMTDVVHDLESMLAELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQX8</accession>
    <name>A0ABR3BQX8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Formate dehydrogenase</fullName>
            <shortName evidence="5">FDH</shortName>
            <ecNumber evidence="2 5">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 5"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613553.1">
        <property type="nucleotide sequence ID" value="XM_066758151.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990522"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="35"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="128"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="310"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="398" mass="44059" checksum="F67255C18A304CEF" modified="2025-10-08" version="1">MVKVLAILYSGGKAAEEESRLLGTVENRLGFADWLKKEGHEFIVTADKEGPNSEFQKHLPDTEILITTPFHPGYLTAELMEKAPKLKLCVTAGVGSDHIDLEAANKRKITVAEVSGSNVVSVAEHVMMSILLLVRNFVPAHEQIQADDWNVAQVARNAFDLEGKVVGTVGCGRIGYRVLQRLQPFQCKELLWFDYADLPAEAAKAIKARRVEKLEDMVAQCDIITINCPLHEKTRGLFNGELISKMKPGSWLVNTARGAICDRNAVKKALESGHLRGYAGDVWDVQPAPKDHPWRHMANPLGGGNGMVPHYSGTTLDAQTRYAEGTKEIIRRYFAGEEQDPSNLIVIDGDYASKSYGDRAGKKKEQSQVKAAKKNEFNELRLSNPMLVLSYYVRSISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR57</accession>
    <name>A0ABR3BR57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612735.1">
        <property type="nucleotide sequence ID" value="XM_066759248.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991641"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="8">
        <location>
            <begin position="163"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="246"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="653"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0245651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="697" mass="75284" checksum="F18773E74C75DE02" modified="2025-10-08" version="1">MSAGHPVLDLPPTMPSASVHIMPSSSATVDDEDDITFDSPEEEIAHYREKYRQALDMLTDTRAELEEFQQSSKELEDEMEQELAANDKQQADLRERIKRLEAEKEEWRTKHIALQKMHSSTASAMQREMDNLRSERDKTLIALRDLEMGNDELERNERVAVSSLLDLESKYNRAIEEKTLLEQDLAQKDELEAETQRLKDELREANEEISILKDQLARAAATPPSSVSTSSPVHEATCDLSRIHLSDDINASPHPPPIPNKNKPITPQGQSPRRGLSRSGTMSSIPVASPSSKRFSQHIPHSPSVSTLSRSTTSRNLAAAAVTPGSPALSRSRSGIPQASPARGPVLASHQQTKSRGFKLLHDLQARLKATDDKLGGAKVPRRNVSNPASVFGVGRRVSSATLAASSNTAVPAPHARITALAKDHNTTPTAQSQPFPGSGIMSPGWVLVGEGEGEDTPTGPWSMTLPIEPDSPLDPTFRSSSTTSNRSLPSRPGIPSPLASGSARSITSSTAQRQTGQRPSSRLGLRVSRRESEARPLSPSMIPVPLSSSRPMSPDAYQPLRSATPTSAFSSFSASASTSNPLRPSSRTGKRNLIGRGPPPLSSSTRLHHQRSRPSLSGAVSTPTTGADKVERAKRGPRRSSFSNMDKPRLTPASTPASAGSRTPSGRPTSVHVFRETPPPVPRIPSAILKESGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRA6</accession>
    <name>A0ABR3BRA6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="2 17">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">I308_104538</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IND107</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="2 17"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612498.1">
        <property type="nucleotide sequence ID" value="XM_066759011.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991394"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 17" id="KW-0288">FMN</keyword>
    <keyword evidence="16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 17" id="KW-0520">NAD</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="10 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="16 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="276"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAL0245414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="725" mass="80808" checksum="02D2B784F8406CF3" modified="2025-10-08" version="1">MTDDPAATPRPETSINARPAISGQAPIRAEYLINTTPIVESASAAELNNIHPDDAAEGRTDPRDSRDDRDGRDNKRRKPNKQDKKDKKGQNKGRHFPVIREASVRICRAWETTGICDRADKGDCRYAHSWEGYFEVKPNDISYRPDWLLVGEAPFVVTGERVVGGEDVVGKTLDLDTVCPVLKDLGYCPFGWRCRFLGAHVKRTTAPVDGEEKEKEAGPEKRMGDWQIEHWVQSEVENGWKQKETNWPEQEVLNALRRSTASFPFSEAYLKKVDPDKPFTLQNKKPTKQPQKRKNIVLDEEEAANGPTAVASAGDDEESAMNAAGNEQNEEKGRVYGETEAIDVPPRPEEKRRLNWEGGRYLAPLTTVGNLPFRRLCVDYGATITISEMALAQPLVYGAKEEWALVRRHESEKMFGVQVAGGFPNRMVPAAEIIANTIGKGGGVDFVDVNMGCPIDLVFNQGAGSALMDSPGRLGKLLVGMNRALGEIPLTVKFRTGVAHGKPNAHKLIPRFATEWGVRALTIHGRSRQQRYSKPADWDYIKTCVTTLRESVAEANLPPVPIFGNGDCFSAASYYEEMEKSGVDGVMVARGALIKPWIFTEIKERREWDISAVERLEGIRKFAEFGLSHWGSDTQGVNTTRRFLCEALSFQHRYIPIGLLERLPGKLNERPPAYRGRNELETLLASPFAGDWVKISEMFLGKVDEGFSFVPKHKSNAYGGEEAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRR4</accession>
    <name>A0ABR3BRR4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_103931</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613814.1">
        <property type="nucleotide sequence ID" value="XM_066758412.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990787"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme synthase central" evidence="9">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="8">
        <location>
            <begin position="195"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0247853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="310" mass="33719" checksum="82550A6A6BE73C0C" modified="2025-10-08" version="1">MSTEGTKPLLEPSVQATELPKEASLASLPSKSYPEIHQGASLLLALRLQGRPILLIGGGVVASSRLYFLLESGAHITLISPLPVDPSISHYISHPSTASQITHLARPYAGRSDPVKVKDFDLVLTAIDDNDLSREVCEMCREERVMVNVADIPPQCDFYFGAQMRQGPLQILISTGGLGPRAGAMLRDLIVDALPDDIESSLEGVGALRRDLRERAPGVGGEGGKKRMDWMKATCDKWGLGQMKKFNDETVRKRILDEGWEKGIVLGPEHLERKGDDWAAITGKVVGNLLALGMAAGFAVWLRAYNTAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRV3</accession>
    <name>A0ABR3BRV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103961</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613844.1">
        <property type="nucleotide sequence ID" value="XM_066758442.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990817"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="5">
        <location>
            <begin position="449"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0247883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="888" mass="98528" checksum="8197E59A1D0208F5" modified="2025-10-08" version="1">MVQSGVEPFTSKQAIPTNAVTFKGRRIPARIDPEVRISSIVEIMAASFAIEEHHITLCLRDEEDNLVTQDNLPCKVYNHDTLKLCASPTTEALIVVASLKSTCRKSLTESMPAILLAEDILPLKLALFNFQKFVGEEEFAAEFLLKGGMRTLIKILDLEGGLRGNALAYALQGIRGVLEYESAWADLTDTFITRILLLLIHANQPNVLRPATAIVRKLVTSLPLSSHHSNQPEFSLSASTKAPGFKPGLGPGPRQDVIGDRQHHHQDHLSYGFDKVYTLIKQLNIVSSGENDEGSVTNAEYLLKILVKRLGTTGDLELVAESLGLINACLRWGNQEDSRQYYELVWILENLGICRYVSRLIPTSTNNIISPHFLDFQSRLCVILQQKRLRSVRPGQYKEHEKMLKEIWEAGKLGELAKTEEIEGGGEEGGREALSGGQLGMSTRSGLGAKAGMVMGLGKFGLGLGEIDRGAEGWKMIGLGEEDQDGVLEEAAMFRDVGELGLECLHWFATHEERFCNLVMEQQAKSAERRCPIGKASAECVKLLCEHYKISQAGTGHHAATSFQPFLLNFPKLHDLVLKFFLRMWQESNSRIPDFYRLIQLIRSHLTLTLSPATTSLIAATATNTRSFSSRTVLIDESLPEFTKNWFDLEQDLLTTDYRTIRDRQMDLLEKEGGMMRRSAVRDLKENVGKEAWDVVCEQRVGCMLQGGWFNTASLLVPDVAVMARANPSKPLRFLRLSKDRKTIAWDDFTQRSGSPSFESLTHRIKITSISSVKQETSAPVNSLSPNLTSKLSFSLISSLPTATGEAYENSLLDLDAIHAAQLAEWSDGIMVLKDGRMTSQDSANYVKILTELALNVRLLDITGNNVEVPEKVAIGAAPKSIDFVFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS16</accession>
    <name>A0ABR3BS16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613080.1">
        <property type="nucleotide sequence ID" value="XM_066758632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991010"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="216" mass="24207" checksum="B14E96E83815A16D" modified="2025-10-08" version="1">MSPAGVIPICTPLHPIWAFDVLTAHLEHTAHTDPPFHNPHDSYSLFVSWHVAKPGRKHVLRGCIGNFLPMPLAEGLKDYALISALKDHRFSPIKAAELPTLLCDVSLLTPFVTIADPLDWTPGEHGIHITFTHPTDHTRSYSATYLPHICPEQGWTKEETVLSAISKAGYKGKVKVGDKVWKRLHVKIYGSIKVEASWQDYVEWKQSMSESVKTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSH5</accession>
    <name>A0ABR3BSH5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103197</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614081.1">
        <property type="nucleotide sequence ID" value="XM_066757697.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990053"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="18"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="492"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="319"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="391"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0249894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="531" mass="60640" checksum="5C577B09FE064B75" modified="2025-10-08" version="1">MAASLQHFGRGALRVAKNYTKGYTDTQTKVREATSNDPWGPSGTMMNEIAQLTYNQNDFVEVMEMLDKRLNDKGKNWRHVFKALTLLDYCLHAGSENVVIYFKDNIYIIKTLKEFVYVDENGKDVGANVRQKAKDITNLLQDESRLREERRSRGAMRDRMLGTIEASGLRGDRDYGEPRSPSQQNEYSRPSPRPNRSRDEDDDLKKAIEESKRMSEDEARRRSVLTQEEDDLQRAIRLSEEEEAKRKREQESATQTALFDDSLNLQSQNAYTQQPDLFAQQTQQMPVQPTGGWPLVDVGWGQQQQQLQPQYTSYNPFYAQMQQQQMQQQQQQMQQQQQEEYMRQQMALQEQQRQQQEWMQQQQYLQQQQTSLLSQPTGYGSNNPFAPSLGSQQTGQIPSPQPQQQQPSFLPVPNVTAQSQSPTPQTQIPEQQPLEPQATARPTWTPQSKTNDGQHGQLASLLARGREDGLDTFGNMGNLRIPVGSTFHNSNRVAVQQTGAGSLGPNNPFGQRQAQQGQQQGQSSEQPFFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSM8</accession>
    <name>A0ABR3BSM8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_103269</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614153.1">
        <property type="nucleotide sequence ID" value="XM_066757769.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990125"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="791"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="872"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1131"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1159"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1186"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1230"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1271"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="13">
        <location>
            <begin position="588"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0249966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1332" mass="145890" checksum="10C09DA045AC3500" modified="2025-10-08" version="1">MPATSSKSRTGRGICAMRGTCGRTSMFGADLPCPDDNDATVPDQDLLDLMSSVCGPSYSIPDHVCCTYDQLSTLSDRLQQAAPLIASCPACINNFRSFYCDFTCSPDQSTFLSVTATQKTTEGKDAVKAVDYEVSSDFKQGFYDSCKNVQFGATNGFAMDLIGGGATNASGFLKYMGDLRPGLGSPFQINFPDNDDSAYGRAPLSCSDAEDINARCACADCPSVCPSLPSIAPPSSKQCHVGAVSCLTFSLLIIYSVTILIGALLYIWKQAARHRQRRYERVALLDPPHSPTIQNGQGNGLDGLMGRNDDAESGPSGSIHFRLGRGASLLDPMEHLQPKQNKINATLRRFFYRLGLTCAKRPIEVFAITAFIVGLFNFGWKYFEVETDPVRLWVSPTSESASQKRFFDDSFGPFYKSEQVFITQSSGSPVNYDTLDWWLKVEAEINALKTSDGIGLEDICFAPAGKGTPCVIQSVSAWLGDDMEVWGEEWESRVSDCAARPGECLPPFGQPIDPKLVLGGANGDWLKAKALIVTWVVSNYNDERAEPAEQWERKLRDYLGNLKRPGIKISYSTGVSLEEEINKSTNTDVKIVVLSYLVMFFYVSLTLGGGLPPSMIQAFAHRVYRLVIRVGVLLHLVNDASLEESAPPPDFRVIPTLLSVNSKFSLGLFGIAIVLIAVSSSVGLFSLLGVRVTLIIAEVIPFLVLAVGVDNVFILVHELDRQNSLHAAQQPDDDESVHSNGAQPSGTFLAPEERVARAVARMGPSIMLSSVTEVVAFALGALVPMPAVRNFAIYAAGSVLFGAVMQCTVFVSAMTLDLRRSESMRIDCFPCIRLRPPVGLYDNEAPSRESMIKKFMRTVYAPSLLRNEVKQLVLVAFGGLFLAAIIGMQHITLGLDQRLALPSESYLVPYFNDVDCYLDVGPPVYFVTEGGDPSSRHGQQQLCGRFTTCLDLSVANSLEAERKRPDSSFIASPPAAWIDDFLQWTNPAFESCCRVKKRDPSVFCSPRDAERLCRPCFEGQEWDSTMNGLPEGEDFMRYLKQWLISPTNDECPLGGQAPYSGAVKLVPSNTTVAASHFRTYHTPLKSQADFINALAAARRISEDITHRTGVKVFPYSLFYVFFDQYEHITSMAIEVLFLAFVAVLVITSTLLGSWRTGGTVTFTCALAVINVMGVMGYWGISLNAISLVNLVISLGIAVEFCSHIARAFMGAGSGLPLDKLDGRKERDERAWTALVDVGPSVFSGITMTKLIGISVLALTRSKLLEVYYFRMWLSLILSGALHGLVLLPVLLSYLGGQGYPLEDTDEDWVTSQMRRPMDYEYAPFADTDSVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSZ0</accession>
    <name>A0ABR3BSZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613975.1">
        <property type="nucleotide sequence ID" value="XM_066757591.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989946"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="120" mass="13124" checksum="B78C1AF9CC661EE0" modified="2025-10-08" version="1">MGDIADLTAKAYNIARLIPPGRVTSYGHIAKLAGYPTYSRHVGNALKMLPPDSEVPWQRVVNSKGIISPRGDLGLGVARQKERLEDEGVEVETLAGAGGERVDLRRWGWFPETLRQDGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTD1</accession>
    <name>A0ABR3BTD1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614396.1">
        <property type="nucleotide sequence ID" value="XM_066758012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990374"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="88" mass="9008" checksum="A0DF59B8F4874661" modified="2025-10-08" version="1">MASLLGGQGQGQSEQGSQNSKKGLGGILGGVTDTVGGVTNTVRHLLLSRVLARTSEAQSKTSVVARPRNLPSMRPGEPGIGNKWRGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTJ2</accession>
    <name>A0ABR3BTJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614452.1">
        <property type="nucleotide sequence ID" value="XM_066756983.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989295"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33517" checksum="238DDA07188817AE" modified="2025-10-08" version="1">MEGTAIRALKRTLNPFNTLRPPSSLSFLQLSSRRASTTSTTTVGTHPALQRRGPALQPRLPSVTNWPWRQIPSPSPDTTVLERTVFARPSDFSPPLLLFAAGVWGLFVISWYALPDPPKRELTEEEKANIEAEHAKAGFWLQLGNRVSGSVYSSAQPILMGGVSLILAGFLIASTRIATRITMVQMRPVNGSGEGKAFLKLTTVGHEMVKRVIKPKEVRIEDCSAYFPSAERATTVRLRVLKPDGQPFKYTLDRFPYNLDFREIKEDYNVVDKEIVLSIPRLQQTFGAILKGKPDYAKAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTL1</accession>
    <name>A0ABR3BTL1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_102460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614474.1">
        <property type="nucleotide sequence ID" value="XM_066757005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989317"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="902"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="927"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1071"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="976"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1083"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1098" mass="119560" checksum="0B727C3DECD012FC" modified="2025-10-08" version="1">MSTHGNLSKRPPLDGTVHIDTQEPSAQSSSNNNDVTGVLRRNQACLQCRRRKLKCDAARPHCATCVRSYRHLLRTSPNTNPVLCCDYDDGTSNHAEEGDSQNKLNAGPSAASANDEGETLGAANGSKKKRKAMGEGRRKKKEEEFEEEIDRLTKQIQELQSRLADKPRAPAPAFNSSLFQNTTAPSPNTFINFFTSNPSQQPASTSQVDPIWGNANSLEQIQSQHTHLVNLGSSSANISHDSRPSPANQASETSRRSSSLHNNTSTPNLTSGESSAGANILSPGEIFNFSPADISNDPWNGAVPDADDRSEPKNWQSFNAKDFSSTTLDPVKGQAQWQGLESVSATFTTTVDGNVAVDTQMETEISMDGLETDVDPAMQQQILMDLFWPGWPAKLPEPNVVNDLIESFFDLVPNLPRTLHRARLLARMALPPTHSNFPHPSLIHAVCAAAAARCPEEVYSKSARDKQWANLGFSVNVSTCNSENIITGFGLRQTMFAKEAVQEGLNTGDRLFDVVRAMIILCRVFIDDTRMLECWAYAGLVARMLLPLGLNVRSAELSLKSIMLPPPVDALEREERRAAVWMAFYHDTVASAASGWGTSMSLDELTVALPVSAKEFENGSEFMEPNPQDIESPDLFLKHPVVDSFVMVTKAAILMNRTNRFVRKWKNRHLRPNDDMDGMDKPEFRELANSITCFQMSFPPALRNACKFNSRRRLDADLVNAHLLPHAAIICLYEPFADLDNPSDQPTRRLISATQGIVGIVQQLASVIGGEEEKFTSIMHPSASICFVTAARTSLLFLRHALNNGDEASASSHRTDCDVVRLALSYFGTRFKIGQHHAQLIEYFLDRASNPTFEKLQAHYPDHPRPGAPALTPDADFGLCVENALNIKRGYWRIKARPSFNGTRFDESSANSGHSQSYSSFSQTQTYFNEVHPPSGPGGGAGISPIGSGNTPGSHGNEGSAPGSGVGGASLKDISMDSSPASGLNTESAASASAGGGQGTADSWQDQFYALSDQLAADSSQAQQSSTQKVEFMNCVPIPCLSDLTKPPAPVPILMSDFEAASMRMAFVPPGTNDAVNTTEPLGVRDEHGGRERRGRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTQ7</accession>
    <name>A0ABR3BTQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613680.1">
        <property type="nucleotide sequence ID" value="XM_066758278.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990653"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="491" mass="53684" checksum="1DCA2BFB85F3F5D4" modified="2025-10-08" version="1">MAQIVPSITSLPVDSNAAPSVEDLQDRLPSICVDYLSHDWSEEDVWASWRNMTRHKYEIANGVRLENASWRTWQKQRNNLKTINPETLNWLKDSDVTWLYGPLHTANVEPVRAPKVASTDERLGIDRPNPAAKKVTKPILKHRTISEMLATSMPSSPVLEGVAGDPVPPTVASVSDRPKIPQTKSDTNVLQTQGVMPRNKSPPRLPNLREELPIDSPLSPSESQQSANKKHISFNTFVEQCVAIADPSQPQPQENNRPDVLEMKPAHQRRDSHGSRPSLSRQSSSTSSAERLTISMLAPTTLKPGPGTNPDLQMVYAPPVEYQSPDRDDRGDAYDFPSPEVNPKTGLEDSEKEYGKDDYFGPAGPAKEKKGIPIPGRESSPIQPKQQPSSPQQDKVEPVSYSPSSSTSSFNASSSPLPGRGILKTRPPSHKIPESETPPLAEFDYNPSAATGIGGMRGSGSSYDYASGSSSPLMSPEAVGGALRRVQSRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTU8</accession>
    <name>A0ABR3BTU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GC-rich sequence DNA-binding factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103397</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614278.1">
        <property type="nucleotide sequence ID" value="XM_066757894.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990253"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="458"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="817" mass="90237" checksum="FB03C9E28F7F3C88" modified="2025-10-08" version="1">MFVKRARPRPSLRARDSDLPDTASTLSPLAKSSITANDAQNSDDSIEIDSNEGSGSILGRKKGLKKEKTKDRLSKKASTLSFGGAADEDEGMAFKPKKSLLSQQVKLPSTPSTSDTTGTPSTMRTSGVYSREYLSELKAATPTRAPRGVTDTVEDDDAEDSSGLSRLAREKYASSFAQDTTAGIPDAATIAAAKMKRQAAMGGNGPASASAENEEDYISLGSGDGKIAIYDAQQGPHPESRLMREEDEGGEGDEDLADYTGAKDKLFLGKNANKAAARRLRGEIGELIADREAEDEDDEETLEWERAQAQRSGLWAEKEPDKVVKKGYTPAPIPLARPLPNISSAQSRVTKALSDLEITKSHNDHNLDVVVQELADLEKQERELRIEVEKVEGKREYMEEFRRWVEMLGNFLEEKFPRLEEIEADALHIVQERSQSTNKRRADDDSDDLALCMGVAAPKEGEQEVDELGRARDATRVTGASSGVRRSRREQRESRRSKRIARKANTGDDEGYSTDSTLADADAEDYAAAQNRLAHRTYALLDDVKAEDFRDPEKGLAVRFGGWRKRDEEEYVNAFGGLALVQAWEFWARGEMVGWEPLRGSAFLDSFRWFHSLHHYCRPRQPRADEDEDLDEEPPLSPEGDLVASMVSTAVVPLLTKIFEAGAYDPYSAPQTRRAIDLTDVVADLTNKDSRKFVALLKAILEVFHSHLLELSSAIIAVTAPDAIPPPAFNPASRSALSRFIHRRIKLLKNILMWKREAPQEVRGLVVRLVGEILRPVLSRTWESGGKELAQDVLSVATGSLSPDLVGFLQQGPSSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTX8</accession>
    <name>A0ABR3BTX8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PIG-P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614461.1">
        <property type="nucleotide sequence ID" value="XM_066756992.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989304"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36485">
        <property type="entry name" value="OS01G0939000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36485:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="10290" checksum="4B3AA93A057ECC3D" modified="2025-10-08" version="1">MSPPITFEPLPLRPRSLLELYIGAACMFTISFLSALLAVSYFYCPAHITWIRPLCEDEHYKYLVPLLIPVTTWFAIANWVGWEYFRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVB1</accession>
    <name>A0ABR3BVB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gram-positive cocci surface proteins LPxTG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615046.1">
        <property type="nucleotide sequence ID" value="XM_066756269.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988573"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01167">
        <property type="entry name" value="LPXTG_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00746">
        <property type="entry name" value="Gram_pos_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Gram-positive cocci surface proteins LPxTG" evidence="4">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="90" mass="9698" checksum="52C63C943492DD82" modified="2025-10-08" version="1">MVFVRAAARSLPRTTKRYASTVPPAGSTPSTSGSSNNNGLLLGGGAIAAVGLYFYYLNNKKKVDQKAEDLKDKTKHDLEDARQRTAKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVU7</accession>
    <name>A0ABR3BVU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protoplast regeneration and killer toxin resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614133.1">
        <property type="nucleotide sequence ID" value="XM_066757749.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990105"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="52823" checksum="5D20171C966FEBE4" modified="2025-10-08" version="1">MAATNAEIYQQSQMPIPMPTPSLNPNINSAPTPGPNAMSVYEDCQSPLDTSANGMYPGDRGSRVVSQPAPLLDQSHLRPGNQANLLSHDRTLELYRENAKKTNDPELIFEFSAFMIDAAKAMIPPEQENDPNPSPAVIKQMEKREEIIKEATSLLKRLADRGFPDAQYFLADCYANGIGTARGKQDFDRAFPLFILAAKHGHPDACYRAGTCCEHGWGCRRDSGKAVSFYKKAAVGLHPGAMYRLGTAELNGALGFPRRPKEGVKWLKRSAEHATEEFPHALHELALLHERGIENVVFVDNDYAAELLAQSAELGYAPSAFKLGECYEYGKMGCPVDPALSIHYYNISAQQNHKDACFALTAWYLVGSPGVLPQSDTEAYLWAKKAAELGLAKAQYAVGYFTETGIGIEANSQAALTWYKKAAEGGDKRAAKRLATGSRSSALDRRLEMEALKEEKRLGAARVAQRSGSGSGANGKDGKDGCLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVY8</accession>
    <name>A0ABR3BVY8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615024.1">
        <property type="nucleotide sequence ID" value="XM_066756247.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988551"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="223"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="365" mass="40046" checksum="80DB125D7CF970D2" modified="2025-10-08" version="1">MSASAEDLSSFFFSTGTVTPDGAVVPSDLFFIPTQLQNTEFNTQPWSISNNELPATEPQAEFNLGQDALAGDDDLFVSYFANLFGNENDADSVGQIDTQQGDWQPSVNDHNIHTEEPFELFGQKKMNEFIGWDFNISVPDANLPPIAPALVSVIPATQAYLTILSKPSIPETPKTPSKPRRTSSSPKAPRIPKSPSKKGSFKDALFGPRVVSSSGPKTRGAISCLACRDRKKPCDGVYQFKCERCISHGTCCQWAESGRGVKLGRKQRDEYIRFIAAQGEQLGQREETTMTMDSMKAPKLPLDFQLDLSSFLSTSSGLGLSTSSAYSSLESLVVQTPDATDMDLTNSTAKVESFKEYRDLNQFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW02</accession>
    <name>A0ABR3BW02_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615192.1">
        <property type="nucleotide sequence ID" value="XM_066756415.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988722"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="82"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="233" mass="25413" checksum="496726E86A2CA782" modified="2025-10-08" version="1">MSQSNKAILFVFTSANKLLNGAPTGWYLPEAAHPYYVLSSHYRIEAISTKGGPVPVDQHSVENFQDEESQKFLKDPEAQKLVKNTKKVEDVKAADYEAIFVIGGHGPLIDLAKSESFAKLVEDFYVAKKPVSAVCHGPGALILATNPTTEKSIFDGARATGFSNSEEAQTPYNDFVNILPFSLEDKIKELGGKYEKANQDWGVKVIWDQGILTGQNPASAGPLAVKLKEILEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW47</accession>
    <name>A0ABR3BW47_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615330.1">
        <property type="nucleotide sequence ID" value="XM_066756553.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988860"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="244" mass="27563" checksum="B0DD9B732B14B33A" modified="2025-10-08" version="1">MEAELQTYRDQLAYVNLSLESDPSNDDLLKLKAELNELIDLTQQAMGHTGAAKGVDAGKEKAKTKGKEKEKEITNWQDQGPYKAGMDCMAKYKDGKWYPARINAVVGSQESPLYAVTFKGYTSSTNLPLSSLKPHDPNAPIPQPQKRRADELTEKEKEKKKKKGEKWMETQKQRAEEVKEKKNAWEKFGKKAQKKGIHISGLEGRSVFRTPDNPYGRVGVVGSGRGVTEYERMGKHKFNEEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW59</accession>
    <name>A0ABR3BW59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_102003</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615331.1">
        <property type="nucleotide sequence ID" value="XM_066756554.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988861"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="26"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="467"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0252611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="569" mass="63397" checksum="16E1F12765C626B9" modified="2025-10-08" version="1">MPDPSIPVVYRKTQHKLVGHNLLYSVSVFLSIGVWLFGYDQGVMSGVITGPYFKAYFNQPTSTQLGNMVAVLEIGAFITSLAAAHIADNYGRRMTLRIGAMIFTIGGAIQTFCVGYNSMLLGRFISGFGVGMLSMVVPIYQSEISPADHRGLLGSVEFTGNIIGYASSVWIDYACSFFQSDWSWRLPLSVQCIGGFVLFIGSFVTPESPRYLVDTDQEVEGLTVIADFQGKALDDASVQAEYKEIRDAVLADRAVGDRSYTALWRRYKGRVMIAMSSQLFAQLNGINVISYYAPLVFEQAGWIGRDAILMTGINALFYVASSLPPWYLMDRAGRRPILLSGAVAMAIALTATGWWIYIDQAITPNAVVICVVIYNSAFGMSWGPVPWLYPPEIMPLPFRAKGVSLSTATNWISNWWVGVSTPLFQELIGWRLYPMHAFFCALSFILVYFLYPETRGVPLEEMDKLFGDESDEDEGDSDFDEDEEAESEISSLVGNPRHQRRSASSSLRPSLPTSRKSSPMPSREASSSRGLFGRITDSELARLDKRNPERHFETMGQFEERPERHLEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW70</accession>
    <name>A0ABR3BW70_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615114.1">
        <property type="nucleotide sequence ID" value="XM_066756337.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988643"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="253" mass="28164" checksum="CD827E7F81342B28" modified="2025-10-08" version="1">MAPLDLGNVGDAIQGAGESAVNGAQGVVASGAGAVATVTDKAAGAVASATAIAGDVANGASQAAGLLKWMKTIQDWITKIEGYWNEYKNLVIFSWWDPTYFARAGGRYELPEDPMERAKWHWWGHEEGWVHKGVESILQCLGTTVDKEKRLMEELSSAAGRDEHFTKLSQEMSRAGGRLREEGEDLKERINRQWAERKGLVHELNRKLTKAEKRMVDRAQSRLEKKMQSEHWNSDDSDNEDEKPRKRDTGGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWG8</accession>
    <name>A0ABR3BWG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_102014</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SQS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615342.1">
        <property type="nucleotide sequence ID" value="XM_066756565.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988872"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02646">
        <property type="entry name" value="R3H_G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034082">
        <property type="entry name" value="R3H_G-patch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="1289"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="1420"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="436"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="592"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="708"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="777"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="834"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1124"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1183"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1229"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="780"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="870"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="981"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1053"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1190"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1229"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1240"/>
            <end position="1249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0252622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1464" mass="160586" checksum="98983D7EE8D1EBD8" modified="2025-10-08" version="1">MSQKQSFADFLASGSPYGGKNRGRGGSSRGRGGGGREGFYGNASKKAYNADYSNVPFDYDKINSQHYKKLEPASVAPYGHRDTSSSHSGPDRNVSSSSSHVPRLAHTPGTATPNKIHGLGFHTPGQLSESGSARPSIEVTKAKTRGSSRGLNGTCWGGGLAPLFIKAGELFKDGEVDVITHEEDKGIDAGHYHMPGASGTRMTDTKHQANVRTFQAEDVDNTSDAVTDGKGEQLKISNQSGSSLSPAASDDSSIFQVVQYTGELSISPSDTNSHQDPVERDGSWKEQVMELPVSGEDQVTGLNTSTKPGPDIVSSFNRREHVDRVISEADSQSHQEDTLFFIDTNPDPDSAPCQTPQYNTIIAPPIGASSPDSDEEDIVFVPRAYNQQKAIGPHVSSLHLRHGMRYQNQGSSKYQSYIEIIDDLNAQPLLGATQRIQSSAEDATSTSQPPQVSVSSYNEELPDSILSDVNAPAASYTDEKMTKRQKKRVSKNAKRLARRAAARGGVPRDDSDIEWGSDGPPKLAGGEQDRTSVSDLVGGGKAKESEAILRDYLEGVRLSQMADEDEDKSGDDDDMAALSKWANRINVLDAEANLDEDSDEESSSALIEAGPNEIYHGPQDKKKLGQDEKDDDELRELEALRSFANRIHDLDEGQDLSEDEEITLVQPQAPKISLKLQGKRREQQKKLGDGDVPDEELMELEALQEFVDRINGQGNGSDFSGDDMGEIEEGQNQPPSKARVKQVKFSSYNQEITHEQWEADEEKLALDKWALRVNTLGGDDCNDDYEDEDMGVSLSSQLDSRRQPRPMECSESSSEQDEEEAELYALDAWVSRVNSHSQGRDLSDDELDTAYAPSKPKLKKEALPKMKQITPPNQSSLYQQPQHVSAEELSQPTELRDSEAEAEATEDNPWALDPKEAEGDNPWAAKEPKKEHNPWSGEVIYEERTFTQSTSLHPRPHNVCSADVSSDLPQKQYGAVVCSPSKERLAEQRSESEDGGWSHGKTASKALDEVHGQEGDSEGDDSSGSSTSEWRYFEDKQEGDMFNGANHWSEGNGSEDDSDEEGSEIGGENDSDSDSHDESEEHEEDEMEVDDYDQTEWFINAMEDALDGKGINFNDPRAKMFNTVNQDSYEFSPTPAKKGKKSKQLKGIPMELQVQWEKDRQTKAEKKRQRELARHLEEFESTIVSGSSRNGKKKRYAKKGGKDSKQIYQASVAHLIPGSAADVADMFSEEEGLSDSENEEYYRPSDRGEMVGVDSFSPSLKPKNARFSMGFKKNKKRSLGKKAAVGPEWRTLDWVDDLIQAFLKDKKSESMSLPPMDKEGRKKIHMLAECYGVGSTSRGSGKKKSISLYKTKRSGADVKEERRERLLTAAPFSGSMFHKTLYAKSSHGGAKTKGRDWASGATAKPREGELVGHGADKIGTDNVGHKLLSKMGWAEGNKIGRGSGSGIDAPIVAVVKNTKSGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWM8</accession>
    <name>A0ABR3BWM8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial proton/calcium exchanger protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Leucine zipper-EF-hand-containing transmembrane protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_101948</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LETM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615276.1">
        <property type="nucleotide sequence ID" value="XM_066756499.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988806"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="14">
        <location>
            <begin position="262"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="113"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="484"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0252556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="730" mass="81777" checksum="8A4CA9110B18E73B" modified="2025-10-08" version="1">MSASTTTAYARLAPPHALVRGAPLPLRLRHPAHLSAVRAYVRSPQALAFTASAPVPLATLAALRTTRPQLLQLVPLASVRHVSTQPQESSLSPHSYPPPLQPQASAANRINLTEPAIGTPPPLPPTPQGSLPPKVTDLAASHEKAVEKEDEKKKPTGPLPARVWASVKKEAAHYWAGTKLLGQEIKISGKLQWKVLNGGTLTRRERRQLRRTTIDLLRLLPFSVFIVVPFMELLLPVALKLFPNMLPSTFEGEFAANEKQRKLLRVRIEMAKFLQETVRESGLKADSVVRSDEFKEFFRKVRSTGETPNQTDVVRVAKLFHDDITLDNLSRSQLVSMCRYMNINAFGTDNFLKHQIRNKLEKVRVDDMMIHAEGVESLSTKELQQACQSRGIRFQGVSPARLREELEKWIELHYINGISGVLLVLSRAFNFEQKGDDIMESLVTTLSSLPENLLNEAELHVSDEASYKQKLEVLQQQQELIEDEAEQEKEEQDARKEEKEKKELEESARREQEEAAKAVEISPAAKEEEPVKEHVEEPVRPAPEQTDARMTKEQLSELAEALSILTAKSSIVKERDELKSLLEDNLLSEAESKERQEGDSPTVAVSKRVRAMIKKIDTQLEKYDEKVGSSLNVIQTTPNGQIALADLKKALKVIKHRPADDVIEGLGKKLDVDSDGYVELDHVVELTQDHGLGIVLEDEEAQNLLASGSDIRHSKDVKEIKPKREDILQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWT5</accession>
    <name>A0ABR3BWT5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615568.1">
        <property type="nucleotide sequence ID" value="XM_066756791.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989098"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="27"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0252848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="378" mass="41839" checksum="2C7986BCFE5731C2" modified="2025-10-08" version="1">MRGADGKRLPLWLNTRTLTSHFFFGPYVLFPIAAALTWLGGILALLGLWVVAGKPRYRRNEASVVFISNVGATHQALFIAICCTVAAFYIASMFAERWLRHVDRLPTNIRRRELIFDWLAIFWCVVGSVGLILLSCFNAFTHGTGHWTMTVVFIVGVAISAIFQSAEIWCLHQEHPDRKSLRRNSVIKLIIVLLAIVLAICFGATYGVCHGDSFATNGHSADTCNRITSAAAAFEWAVAFVLTFYFLTIAADLWPAGKSSPRYMRSLAQWQERHGEGHDFTGRRAFGIYPERWQDKEAIMRENMLARNRGLATQVNNGSYTSYDPANGYVAPIGDGVTPLPPAHVHNGSIDYSAMGEGTEARTSMAGSDAPMMRQSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWV2</accession>
    <name>A0ABR3BWV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615592.1">
        <property type="nucleotide sequence ID" value="XM_066756815.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989122"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0252872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="293" mass="33295" checksum="7F0172B414F0CDCD" modified="2025-10-08" version="1">MKYLQGCNTREQLIFPPFHFHKWRAVDDGVRGGSSVSHLTPVKIDVQGQVTGAPELEESRDVFGEKRHNKGDKNMAARFWGNLDIKTLGGAGFASQAFWYGPYPLHLPPIRYNGIVISALPDPLQPTKARAPCSKKPMEFTFVIKTTPTSHIPKHPKVPPPRRAAKLTYEVRFTLAEAKNQGKTPGEQKFYFPWRDFKATYRGREVKEGDDPKWVPLDTSSIYEVNLMCRSGFGQQEGEFGVIVTGIYAWEKEEKDQKVAGCWQGVKEWFRYVTGYDVGVKLEESDYEKQFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX67</accession>
    <name>A0ABR3BX67_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_102101</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615429.1">
        <property type="nucleotide sequence ID" value="XM_066756652.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988959"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="12">
        <location>
            <begin position="11"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="11">
        <location>
            <begin position="387"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0252709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="591" mass="62175" checksum="C2E27E7BD43FF354" modified="2025-10-08" version="1">MAPAQKHLLNTPQTLVVDSLRGLATLNPNVKLDEAQRVIYTPPSESKVALLSGGGSGHEPAHAAFVGPGLLSAAICGNIFASPNVAQIRRGVELVTREKGSLIVVMNYTGDALHFGLAAEQHRSAGKVGDVRVLMVGDDVAVGREQGSIVGRRGLAGTILVYKVAAALSDKGGDLDSVENIAKYVASRLGTLGVGLEHCHVPGTRAGTSHLGANEVEVGMGIHNEAGTYKLDMTTVSELVGRMLTQITDTTDKDKSFVPFKGDGSDEVVLLVNDLGAISELEMGGITNEAVKWLQSRNIKVRRVLAGTYMTSLNMPGFSLTLLLLPSASEKPPYSAHEILEYLDAPASAPGWKWHAGREPGTLDVKTEEAPIPVQKDNAVLPSTDSKGFLAAITRACKALIAAEPELTEQDQIAGDGDAGLTLEAGAKGVLKAIEQGRLKGENVVQDIKIIAEIVEEDMGGTSGALYSIFFAGLGKSLRDAATNGAKNTTPEVWSKAAAGALDTLYKYTRARPPSRTLVDPLDAFVASLPSKGLSSAAEDALAAADKTKELVAKAGRGAYVNQEDLKKREVPDPGAWGIWRIVDGLRGFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXC6</accession>
    <name>A0ABR3BXC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipid droplet-associated hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614688.1">
        <property type="nucleotide sequence ID" value="XM_066757219.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989535"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38732" checksum="186CE0F93449F08F" modified="2025-10-08" version="1">MDPRLAFLRLTEDITFSLPIICSFQNRTSGAVGQVELNYWPPRNGASKAPDHLLLFILGNPGLLGYYPHFLSHLHSLLPPSHAILATSHIGHSTRVPGPTVPLSLSQQVASKVELVEAIRGYLDDWALKEGQSKPKFSLMGHSVGAYMACEVMKELNTEKARPVCAGYLLFPTLGWIADTWNGWTLWPIFHRPVKPVLPYLSPLLRPLFSFVNLPETSQSLLLSPVILKDVLSLSSDEMRQIRELDTEWFKAQGTGQAGESEGLFGVWTKGNGDGWVGKDGPLVQECLGGEISGRVKVLEGVPHAFCLTREHSEMVAGIVARWICPNGFRPETPSVPAEQPHHPLGSNIVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXK7</accession>
    <name>A0ABR3BXK7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614996.1">
        <property type="nucleotide sequence ID" value="XM_066756219.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988523"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="125" mass="13861" checksum="307CD95F8B5E864D" modified="2025-10-08" version="1">MRHPLTSLFPSEEHGPETETSANSLHGGQDLDFSLHPSAVITHRAKNLNSKRALSFVITSISFITCIQFSHIYAYQSPALSKKTYCTSLVESLLGKQLLLLFSLSHTSGEDQVFPGRDTEEILLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXY2</accession>
    <name>A0ABR3BXY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BNA5</name>
        <name evidence="7" type="ORF">I308_102082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615410.1">
        <property type="nucleotide sequence ID" value="XM_066756633.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988940"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="6">
        <location>
            <begin position="97"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="453" mass="50964" checksum="F48857BFAC845E07" modified="2025-10-08" version="1">MSSDLPTKEELVKWDQDDALNWTRGEFEIPNSKACGGEADGKAIYFCGNSLGLLSKKARQHIMEELDVWSTSSVTGHFKHPYQRPWKHVDEPLTPHLAKLVGAREEEIAHTSTLTSNMHNLFTSFYRPTEKRWKIVIEKGSFPSDWYAVHSHPRLHDKVLSPEQIDNAIIALVPREGEDTLRTEDILKVVDDNKDSIAIVWLPIVQYYTGQLFDISSISPKVHEIGALLGLDMAHGIGNVECKLNEWNVDFAVWCTYKYLNAGPAAIGGFYIRSGLDDGGRRLAGWWGNDASTRFHMSPNFQPTPGAKGYQHSCTPVLSSIPLLATLQLIEAAGFSSMVEKGRRLTGSLEALLKASRYYVHPADPKGKIGFRIITPAAPYRGTQLSLVIMPEEEHVMPNVFDRMLRMGLVGDERRPSVIRLSPVVLYNTFEEVGRAVEIVEEALREEEEERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYU3</accession>
    <name>A0ABR3BYU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615386.1">
        <property type="nucleotide sequence ID" value="XM_066756609.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988916"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="33"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="149" mass="15880" checksum="C8E41B341E8F4DDA" modified="2025-10-08" version="1">MSDAGSETASNHPEVEAQEVEVAAQSGPMSVEDALEQVIKTALVHDGLARGLRECAKALDKKEAHLCVLVETVTEAEYLKLIEALCTEHGIQLIKVSDAKVLGQSLAALALSSPTTVRTLPLSRSSLSTSRPAKCLASLLLDSIRFCPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYW3</accession>
    <name>A0ABR3BYW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615179.1">
        <property type="nucleotide sequence ID" value="XM_066756402.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988709"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="9">
        <location>
            <begin position="59"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="10">
        <location>
            <begin position="328"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="569"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="507"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="597" mass="64462" checksum="CA21BD04F1049FBF" modified="2025-10-08" version="1">MYPRSFTLPPARPRPLSYVFLSLARTLIPQPPPPLVSSRPLPTNFKKPSPQSESNKLFMEGLIRETETLRAQAKEGGGQKVLDRWKAKGTGKLSVRERVSALLDPASPFLELSPLAAHDVYPDALPGAGLVTGIGMVAGRKCMIIANDPTVKGGTYFPLTVKKHLRAQQIALENALPCIYLVESGGAALPYQAEVFPDYDHFGRIFYNIARMSGMGIPQISVVHGISVAGGAYMPAMSDVVIIVKDQGRIFLAGPPLVKAATGEIVDEEALGGGDMHTSVSGVADYLATSDSHALRLAREAVRDLSPIPVAQTLPSASKATGIKEVIPPLYPTEDLNAIVPADPKQSYDPREIIARLVDGSEFREFKKEFGKTIITGFAEVHGYTVGIIANAGVLLSPSAQKATHFINLCSQRGIPLVFLVNVGGYMVGEKAERGGIAKDGAKMVRAVARAKVEKYTFIVGGSYGAGNYGMCGRAYSPRFLFMWPNARISVMGPDQLSTVMHTVQGKRAQENEKGAEEAERKRQELRDAIEKQSMGIYSTARLWDDGIIKPSDTRDILGLTLELAHEERAKRPHGGQGTRGEIGADGDSGDWGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZD1</accession>
    <name>A0ABR3BZD1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prephenate dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100907</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615755.1">
        <property type="nucleotide sequence ID" value="XM_066755469.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987765"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0253534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="318" mass="34743" checksum="D99EEB83013F8952" modified="2025-10-08" version="1">MDTTSSSEPPAKRMKETKRVEMAFLGPRGTYGEQAARAFATRYSDPIDLVPCTTITDVYNHSAPLIVLPLENTLQGGVLETLDCLLSVLKPSTFEDPKPLERKIVADFALPIRHCLVVRKGTKMEEIRWVRSHEQALGQSSSFLAERLPGIKLEKWSSTAGAAVSLLQNTGNADDKGAAICSKAVLDLYPDHLEVLHEGTQYGNENYTRFLLLTVPSPNILPKSDRQLPSTDRTSFIAVPNPSLGAMLLSFHPSSSICSSTSVTAIHTRPAGEGVIYKDEKFPRWCLLEVVNGATNTVEDAVNLGSLREKLGPELLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZR0</accession>
    <name>A0ABR3BZR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="3">SDH assembly factor 2</shortName>
            <shortName evidence="3">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDHAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616092.1">
        <property type="nucleotide sequence ID" value="XM_066755806.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988107"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="175" mass="20274" checksum="3EBCF637E865267B" modified="2025-10-08" version="1">MSVLRTLPRVARAVRPALPSLRPISTTKIIFKSPTADPFPLPFSDPELAHANNALPSNAEEWPLPEPLDRTGEDEKTLRARLIYQTRKRGTLETDLILSTFARDELPKMDFEEMKQFDKLLDEPDWDIFYWSVEKREPPARWNGSPILEKLKKHAKNEGKVVRMMPELMQKEPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZZ4</accession>
    <name>A0ABR3BZZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616118.1">
        <property type="nucleotide sequence ID" value="XM_066755832.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988133"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF23">
        <property type="entry name" value="ZF-C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="230"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="437" mass="47732" checksum="6C73C3AE4AB28D61" modified="2025-10-08" version="1">MSPPHTSTLTRPSSPSSNSGTEVVLTPTTRGEESRTTVDVHMEQAAEESAQGVAERASKKAKISDSSSFGQENDIDFAGITNQRFTVFPMFTGAWNQATESNSTSPIPMHPANAMQSPSHQQSQQQNGLDPLLALRSPSATHSTPQVNVDVGLTPELRFPDETLASATAGVSQEAPQGDHSPIQVDESSQQQPPPGMLAVPSSRTGPSSTSESGQATKKENNPSFSRSPELRVSHKLAERKRRKEMKDLFDELRDELPADRGMKASKWEILTKAIEHIKHTKSQQVEMHREIEHLRRELEIARAGNAHYHPHAYPTYSIPYPPGPFAAHPHHAQAQPPTSGATSQAHTPQPQTQTVAQPQLQSQVAQQPQQVQQQPQSQPQQQIQPAAHVQRIPQVQQQQQSQPQQPQQQSQTSGLQTPAQEVQQQPLSAQGTPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C068</accession>
    <name>A0ABR3C068_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_100918</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615766.1">
        <property type="nucleotide sequence ID" value="XM_066755480.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987776"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="191"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="395"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="18"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="561"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0253545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="641" mass="68289" checksum="8829415676FFAD24" modified="2025-10-08" version="1">MAATDVNGLASQMNSVNLNGAAQKPQKPAYVPPHLRNRAAPPAAAAPAAPAAYRPSPTGLPTPATTPPTRHSVPAALSEDDVGGWGAQPRVRKTFEHGAPPGFGSWKNGQHVVGARNMRMEKEMYGEVGDGLHQSTGINFDKYADIPVEVSGKGVPEPVTEFTNPPINPVLLENVKYARYTTPTPVQKYSIPIVADGRDLMACAQTGSGKTGGFLFPILSALFTYGPSAPPVEQDTGYGYRRTKKVYPTALVLAPTRELVSQIHEEARKFAYRSWVRPAVVYGGADIGSQMRALDRGCDLLSATPGRLVDLIERGKISLANVKYLVLDEADRMLDMGFEPQIRRIVDEEDMPGVLDRQTLMFSATFPREIQNLARCFLKEYIFLTVGRVGSTSENITQRVEYVDDQDKRSLLLDLLLAEQSGGLILVFVETKRMADTLCDFLCSRRHNATSIHGDRTQREREAALYAFKSGRAPILVATAVAARGLDIPNVTHVILYDLPNDVAEYTHRIGRTGRAGNVGTSTAFFNRGNSNIGKDLIELLKEANQEVPQWLVEISSERSYGGGGGGYRGGRGRSTGGGGGRMGGRDMRQGGGGGGGGGYGGGGYGGGARTGGGYGGGGGASWGNGGGFPPAGGDSGASWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C097</accession>
    <name>A0ABR3C097_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5 13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I308_101424</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IND107</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5 13"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616266.1">
        <property type="nucleotide sequence ID" value="XM_066755980.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988282"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="15">
        <location>
            <begin position="11"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="16">
        <location>
            <begin position="226"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAL0254045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="379" mass="42971" checksum="C33F566FBF87456F" modified="2025-10-08" version="1">MSPAHLEIPNFEPTEHPHRRYNPLIGKHVLVSPHRTKRPWKGQTEEPVLTTLPEYEATCNLCPGNERSNGNRNPMYMDTFTFENDFPALLPGPLPSLQQPSKVNPSDTLFASEPIRGRCKVICFHPKHDLTIARMNINDVVRVIREWKNVYMEEGRMLEESSGQGYVQIFENRGAMMGASAPHPHGQVWSLSYVPDEPQMELNNLAASTLMSSGNAPVRGDGCPCLLCTYAAEEVGRKERVVEIDEESGWVAVVPFWAVWPFETLLLPYKRHVPSLIQLNDCEVIGLARILQRLLVRYDNLFSCPFPYSMGLHQSPLPPSDPDSDVAHIHFHFYPPLLRSASVRKFLVGFEMMAEVQRDLTPEQAAERLRALPGVHYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0I7</accession>
    <name>A0ABR3C0I7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_101520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase d subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616361.1">
        <property type="nucleotide sequence ID" value="XM_066756075.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988378"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0254140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="173" mass="18865" checksum="DA95AFE112FD857A" modified="2025-10-08" version="1">MATKSAASVVDWSKIYTGLGLDKQTLTSLQSFRARHSAALNKNSALKATTPSIDLSHYKSVLKDQQAVQLAEKVLGEFKPVDYDVSKWNGVVEAFEGKAIAAAKETVSKISTEEASLQATLSNIKDARPFEDLTVDEVAKARPEIAKAVETMVKKGKWSVPGYREKFGDLSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0L3</accession>
    <name>A0ABR3C0L3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616391.1">
        <property type="nucleotide sequence ID" value="XM_066756105.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988408"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0254170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="262" mass="29403" checksum="CF91BC87DDDB7147" modified="2025-10-08" version="1">MSWGGFKKAATRAGTSIMQKTGQIERTVDREFAEEEGRYKTMEKETVNLQKEAKTYLDSMRSMAASQSRIAETVALFYSADRTSDGAMAGHAYKSAVDELDAGVGRELDAPFRATVLDPIGKLNSYYTNINAAITKRSHKMSDYDAARAKVRKLVEKPSDDSTKLPRAQSEHDEARDIFNILNDQLIAELPVLVDLRIPYLDPSFEAMIRCQLNFAQEGYERLSGVQRYFADNIRDDYANGALDAQVETVLEEMKELAIFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0S1</accession>
    <name>A0ABR3C0S1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616439.1">
        <property type="nucleotide sequence ID" value="XM_066756153.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988457"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0254218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26242" checksum="F54A5D66816ED74F" modified="2025-10-08" version="1">MPRVTRKQKESGKAPKPKPRAKSAPNASAKHGFKTAPSRAPKDAYLGKAKKIKTDLIQRAKVKKQFAKVLRAEGMESERLGDGSRRRNEREEGDNKRKGRTGDSMGKERREREERGEEDPDMARIRARAGPSSSTPFSRPNKPFNKSHNNKSYDRTTRKPRIEEAPPKPKVRALSPSPPPSAPSSEPKPSIRTLKKEGFSKYHRVKDTTGLSKGRGQPNMGARMGVLLEKIKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0V3</accession>
    <name>A0ABR3C0V3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616474.1">
        <property type="nucleotide sequence ID" value="XM_066756188.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988492"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021755">
        <property type="entry name" value="TF_Aft1_HRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020956">
        <property type="entry name" value="TF_Aft1_OSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11786">
        <property type="entry name" value="Aft1_HRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11785">
        <property type="entry name" value="Aft1_OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="540"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="565"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0254253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="619" mass="64429" checksum="F61ADDDF4ACBE850" modified="2025-10-08" version="1">MAAVAQAPPSMPHPPIENSVTRPSSSASNSKRQQSEAPVSKGSEENSNLAATVTVTESTPVEDKENKESGNAEAGSSDKDKPADQASEVQRPPIRPNAVARSRLEQEPNPFEQSFRDSHGPGRPGTSDRDTPPRGTDATSTRHNALPPLSSLTSPAAADPTQFPWLANQSLRSGPLSPAMLTGPQGANQSSTSNNLRSNEANADGGFESSSFRTGFTPGTGSGFTPGYNSFINSSLNSLPIPSPNTAAFLNSITNVTPLGESSEVAQAAAAAAAQAQGQTASNSSSASQTSQPATEQLQPPSAIPPHMQPHSHHPHPLSHAHSPANNHSAHPGQDTITPNTLNALTGVFGDMSRAPAGAPGQNQFFAPSMSAHPGHPGHPGHPHTAHPGMPGVAGVPGVHGVPGHPGVQLPMGYVDYAQHNANAASQAANGLFLLSQAHQELSKREEAEGTPGSGIGGPTGRSTRGGKGANTPTPQTGSKRKSDGAARGNAKKGKKATGAAAAASIQAQKKGGSTSGSGNGSEDEEDGSDRKDQKFETEEEKRKNFLERNRQAALKCRQRKKAWLNELQSKVEGLTMENERLQQTVQQMHEEVSRLTAILMQHRDCGLGIPAPYGGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0Y4</accession>
    <name>A0ABR3C0Y4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616463.1">
        <property type="nucleotide sequence ID" value="XM_066756177.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988481"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="4">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0254242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="403" mass="43125" checksum="B02EDBDC948F68F1" modified="2025-10-08" version="1">MMSDPSSPKPADAPAPSSSSSVDPQAIRAEVEKLVAEGKKAIALHEWEQGVDRYATALDRMRLLVGDADPEMAPLLLAYGKALYDLASSQASVMGREEPVRQEDDVPAEINNPNFVFSGDAPSDDEGEADEPEPEVGPLASSSSAPAPAPDAAEGDEMEELEDDYNAAWEVLDVARTIYQKIVDGLKEGEGNKERMLLSDCYLALGNVSCETENFPQAVQDFTAAVDIQNTIIPPSFRDLASAHYQLATALEFTPSPQSRTSALTHVESALSSLVHRKEELLSSDESTWSEEIKKMTSKEKEAELKDVEALMGDLQAKIEELKAAPPAEDLIHESISHLMGQSGEASGSGSNNVESGPVNDLTSMVKKKKPKATPAAPVPVVEKRAAEGGEEPAAKKAKNDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C2R2</accession>
    <name>A0ABR3C2R2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616045.1">
        <property type="nucleotide sequence ID" value="XM_066755759.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988060"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="231"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0253824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="516" mass="56850" checksum="C43AB918BB265E4F" modified="2025-10-08" version="1">MLRQSTYRLLSSTPRSSRLISTTAPSFIRIRTQSSEPSPAERPPPVPENVNPSQPFEPEVSKPVGTTKAVETQEAEEPAPAGTPLTPPQPEVVSGNTQSAASVAPETEAHVENPDYSKLPSLDIDPEAAAIPEPAAGKDQETESGGRKKTGAGKKEYVSSQEKSRRMWIRAGYGALAVGAVGAVLAMGSEEAPGKKQGGFVETFQNNMTELFDFFNKPAFKTLLPDPLPPPHQRPYTLCIDLEGLLVHSSWDRTHGWRTAKRPGVDYFLGYLSQFYEIVLFSSQPLYTAAPIAEKIDPYQAFMPYRLFRESTRSVKGKVVKDISFLNRDPSKVIVLDVNPEHVALQPENAIVLQPWDGSSRDKGLVDMIPFLESIGIFNPTDVRPILQAYAGKDIPIEYAKKEAEAKAKAIEEWERSHPTAITGAGSGFLSSIFGSVAAPGSSRPNQPMTYLEQKRAQAQRIYQEEQKYWAEHADEFKKLIEEDKQRQLAEMKGSILGYLGAPKMQDGPKEDVLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3Y5</accession>
    <name>A0ABR3C3Y5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616624.1">
        <property type="nucleotide sequence ID" value="XM_066754723.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987004"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF74">
        <property type="entry name" value="AGR407CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045909522" description="Peptidase A1 domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="278"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="599" mass="62802" checksum="0CA7B59F62296F0A" modified="2025-10-08" version="1">MRPISPPTLLRILLFLIFALSFVLGAPAASFQMTCRQTGQEHSYLVERLIADSSRSYRPPTRKSVVARIGRRAVVKGTYGSKVVPRQNGASEKVPSSAISAAATSENVVASQPDFSASFPGTEGLSQSSAGAGVTDSSTDMGQPSATASASVTNSVTTSATEEARGLQSSSDFDLISRILALSSIEPSATDSVSNVNNDFESNGGALTVTSSTGSISSKGSLFFVSATGTDASSSSGASSQIDTTSALTTFAQSIWAQPLNSSASLTGVMSQNNAIVYTIDVTIGEGGITLPVLVDTGSADIWVAASGCDNCTAASMVDSGLILPEACEEENKGYGSGSVRGCFVNTDIIIGAYELKQFHVLAASDSQGFDGSYMSGIFGLAMNKSSIGNQATPMDTLSQLGMISTPEVGFYLTRTESESELVFGSPHDNPHADQSKKITLPKSTTGDGLYRVIMDGFISHGYMVQGSNNSVSMEKIEVILDTGTSDIRVPEDMLLPIYAALGNGTYYLDTTTGDLVVPCKSNDDAALALQFGGQQFYLSWQDLIANPSSTDANYCYCRVQASPSVISDYLIVGSIFFHNVYHVINTDTGDITLYGLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4A4</accession>
    <name>A0ABR3C4A4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616581.1">
        <property type="nucleotide sequence ID" value="XM_066754680.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986959"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF60">
        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="561" mass="59817" checksum="A5FCF149772D1B34" modified="2025-10-08" version="1">MIRTAVPTARALSRSKVLLRVATLARPGAISASRYINTEPVKGSPSDLKSVPSQGTHGRSRITPSEKSKVWPDAKTAIRDIKNGDTVLSAGFGLCGTAETIIKAMRESDLKDLTVVSNNAGNAGTYGLSPLITSKQIKKMILSYLGTNKGLQDAYLSGEIEVELCPQGTIAERLRSAGAGMPGFFTRTGAGTDVETGGIPQKWSKPDANGKQAIAIPGVKKDTKVFDGKKYLFEPAIHGDVAIFRAWKVDKAGNCVFRYTTRTFGPLVARAAKLSIVEAENIVEIGELDPMEIDLPGIFVDRVVPATEDKQIEIFTTREENENISPGSGEETSVKKGAGQAQRETIAQRASRELYDGAYVNLGVGIPVLAANYLPDGMKVWVQSENGILGMGPYPTKEEVDADIINAGKETVTLVPGASVFDSSESFGMIRGGHVDVSILGAMEVSANGDLANYMIPGKLIKGMGGAMDLVSNPDETKIVVVTTHTDKHGRPKIVESCKLPLTGVAVVSRIITDLAVFDVDRTGKNGGGLELIEIAEGTTLEEVKEKTGATFRVREPLGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4F4</accession>
    <name>A0ABR3C4F4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_100291</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616764.1">
        <property type="nucleotide sequence ID" value="XM_066754863.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987149"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="13">
        <location>
            <begin position="42"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0255487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="446" mass="48437" checksum="B7ACA79AC22DAB13" modified="2025-10-08" version="1">MSAIRAINMRKTASALKAPIAFKRTLATPVNSLYTPILPAKIPAALHLKSGQSYYGSSFGSENSKFGETVFSTSITSYTDSMTDPSYLGQILVFTSPMIGNYGVPSNVSSQFPGIPFLESEKIQCTGVVVSDVALKYSHYQAVESLHEWCKRYDVPGITGVDTRAITSLLRDQGTTLGRLAVGDEAGKPAPQESEYWDPSKENLVAQASTKKPYVLNEKGSGPRIAVFDFGIKANILRSLVRRDAVVTVLPWDFDFNAVRDQFDGLFLSNGPGDPKMIMDTAMRIRQTINEWNKPIFGICMGHQVLGLAAGLEAYRMTFGNRGHNQPVLALASSGSIKAGRVYVTSQNHQYALRLTEDFPEGWAPFFINCNDSSVEGIISTPESGKRIWGVQFHPESAGGPLDTIEMFSDFVNECDVGRMGFNASAMVANEVKVDGHAAKAASVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4P0</accession>
    <name>A0ABR3C4P0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616861.1">
        <property type="nucleotide sequence ID" value="XM_066754960.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987247"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF3">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35437" checksum="105F474E48A74263" modified="2025-10-08" version="1">MKVIVLGASGFIGYPVARAFVQAGHFVWGQTRSESIAASTLSPNEILPIVCDPHSPEGQKKWGELAKDADIVVDCIAASGPDNALAAFNTFLSAVKDRPKWGPKPTYIYTAGHWVFSRGAGGLDKWTDERRPALAALNSPTIWRTKVMEPVLSNENVNGIVVAPTCLYGRSGSYFAYYHFDAALAAVEKGEKEFETIMRDDSRLLTIHQDDLADLYVRVGERSPACKGQVFLAANPSPESLKEILDSVIRVTGLKGYKAKEATDPYEKFWVSTLLAKPSLGTALTGWRPKRLPLTDGMDIYWHSYVASKKRTVTTCSQIDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C555</accession>
    <name>A0ABR3C555_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amine oxidase</fullName>
            <ecNumber evidence="5">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616577.1">
        <property type="nucleotide sequence ID" value="XM_066754676.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986955"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="6">
        <location>
            <begin position="83"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="544" mass="59830" checksum="09F29503D1E8F79C" modified="2025-10-08" version="1">MDLSRGGWSASAHCFGTMSPQTHPLTLSLSLNSVRYPQSPPTKNPFQTSLFIMVTSVVSSVNDSFDGLTIAPEADVVIIGAGLAGLCAARSLHEAGKRVVVLEARGRVGGKTLTVTSKSGGRVDVGGAWVNEHTQPEVCKLNKEAGNILFKQRVLGTTCWELSEDRQLRYYDDGGVGDNSPIPLEGEELEDYNRIFKELDRLSRTVNLENPNSTPDAVEYDSITVANWLNQMDAGQISRQALTPLVRALVGAEMHETPLFYFLHYAKTAKGFFDLIAADETGGQFQRTRYGNQTMSTWIQNHVLPPGAVKLNAAAHQIIQSPDGESVRVITRDGRQFTGRRVICAIPTPLYPNIVWQPSLPVDKTLLVQRSFLGTYTKVVLLYEKAWWLEAGFSGFALSSEWPLSLVFDTCDGWYGSDDPSLRPRQHSLSCFVVAANGVAFSELSRDRREQVVKQQVARMIGSPELVNNTIEVLEFQWIKEEFSQGAPCPVTATGAFTLYGDSLARPHGLVHFAGSELSDVWKGYMEGAIISGRNTAKEVLELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5H6</accession>
    <name>A0ABR3C5H6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617154.1">
        <property type="nucleotide sequence ID" value="XM_066755253.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987545"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="404" mass="44583" checksum="99C25EA31F7384E8" modified="2025-10-08" version="1">MSAAAASEAGPSSTNPPAAEGKKQPVVILCIGMAGSGKTTLMQRLNSYLHSKNTPPYILNLDPAVSHMPYSANIDIRDTVDYKEVMKQYKLGPNGGILTALNLFTTKFDQVLGYVEKRAETVDYILVDTPGQIEIFTWSASGAIITDAIASSLPTVVAYIVDTPRTASPVTFMSNMLYACSILYKTKLPFIIVFNKTDVQPHEFALEWMTDFEKYQEALNDKSRDEHGEGSYVNSLMSSMNLVLEEFYNNLRAVGVSAMTGEGMKAFFSAVEEARKEYETDYKPELDRLAAERAAQTEADKKAQLERLMRDMSVSDSSRSGLGGNPFGPHARNDREDRYYDDEGEANDIDEEEQEAIRRQMEEEEEDAEAEELGKLDVEEPEIGGLASGAAAAANRGVTWPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5S9</accession>
    <name>A0ABR3C5S9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617106.1">
        <property type="nucleotide sequence ID" value="XM_066755205.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987496"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07627">
        <property type="entry name" value="BAR_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06861">
        <property type="entry name" value="PX_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035803">
        <property type="entry name" value="BAR_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037868">
        <property type="entry name" value="PX_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="515"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="807"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="896" mass="98430" checksum="12729977128E8CAD" modified="2025-10-08" version="1">MDEEQTFANLISSTTLPSRPTWDAPSTSPSHDADPWANPFSADTTTLPTAFSSPALPSSSPKRTTVSPYVEQLEKEATARPFPDPPSVIAAREQELVQKAEALAQQRNVYASSAFASPFESPAINAGPAADDPFGNPFAQSSSMAQGRDPASILFPPAPANEPLPPASSSQAEEQGKEILKNLIDDGLAEDGDSGRSLKRAFKKSAQVPREKREVGSQRSKAYVFSPKKKDSGEETKQKSLKDDMQADKVADGVEELSLSGKNALEEDRKKEDLDQHQPQETSIDIPSPTTPKANIRTPRSPTSVPLPISVVTTPVATRQSTPAPPTENSPIHTKAQTKAGKEKDETSPVTLSTPLSNRVSVSPLDAPSVEESYKNLSIGDSSPTQTHSSRSTWNTPQPEESQPPVSTTATRFGGRGWGSLDEDDNDGLFGKRTLGLTSGSVTGAMASWGEEEESGWGEPGLAGLDGSTTLSSDERSDEPTPSQPKLEPEPPYASSASSDSTTAHTLPTKRPTLPYFEISVSDPTRVGDPVRGYTVYTIRTRTSSPHYRQSTFSCLRRFSDFLWLFEQLGHNNPGVIVPPMPDKHSWGRFEDQFVETRRLALERCLKKITSNPILQLDPDLRLFLESDNFAYESKERKHQIAVQTSSTEKGGLLAGWTGAKFVEQDEWFNSRRAFLEALESQLKSLGKAIEISSKHRVELAVSLADYAESLTALAESDLGASLSSALSQMSSLVARERDYAEWHAKSEVGELLNLADEYIRFIGSVRSAFAARVDGWKVWQEKDKEVARMKAAREKARVSGKLGDRVQSSLKEIMEAERRVREASLEYDRLTKLVKSEFVRFERERVLEFKETLERYLDGLIEKEKEMIKGWEGLHSVVARVMKKSQGGQSVGQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5U5</accession>
    <name>A0ABR3C5U5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617270.1">
        <property type="nucleotide sequence ID" value="XM_066755369.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987662"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="550"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1048" mass="114662" checksum="230AD2EB415F0A2C" modified="2025-10-08" version="1">MPVPTFLAQSVTELISLRAETQANDAAIHTGSSEYGEKLMTLTYSDLSKAVDRLAAHYAALNIQPECGLSEVPPERIVAVLTSTAIDETLLEIALAKLGLASLLLSVNNSTAAVAHLCKVTKSAFLIYGPKFEETAKDAQKLLAQEGIEIGVIPETRYPLWGPEGVRESKVAPHPPRLTPQQESKRTCVVLHSSGSTGFPKPVFITHYGLLANAAQSLPKTGFSALPLFHGFGHFSVFRCIYHGKTFTLMPPNLPLTSANICRIIRSSPTPPVQHFAVPYVLKLLGETEEGIQTLANFEAVSFAGAAVPDDLGDRLVAAGVNLISFYGTTETGALMTSRRDFDSDKGWNWLRAEGPIADYLELIPQGSDTFEAVVKDGWPAKIMSNREDGAYCTKDLVLRHPQHKTWFKYIGRLDDTLTQTLGEKTNPVPIELAIRGNSSLIQECIVFGDGRPQTGALILPSEQGAELSKDKKAYIEAIWTVIADANSHAPTHSRILPEMVDVLPYGTEIPVATKMSILRPACYKKFAPIIDAIYERFERGTGEPKQDISSKPEMESFLNSTILQALGDKAGPDLSPSTDLFSYGVDSLQATRVRNVITKSLELGDAKIGQNIVYEYPSISQLADYLLEVKSGKTGQNGPEKDYKTMWEMVERYTAQLIKGDSSSAGSDVSSNGHFSHVIVLTGATGSLGAHILDQLVRRPDVSKVVCLSRAKSHEDSLLRVQGSLSQRLRTLTPECESKIVSYAADVNRPDLGLSAEEYEGLRRESTAVIHNAWPVNFVLSIDSYNEHIGGATNLLNLTLKSPKKVKPAFFFSSSVGTRQGQTELVVGEDFPESPETAHALGYGRSKWVVEKIMEKAGKETEARCGVLRIGQLAGDTENGVWNETEAWPLMFKTVDVIQALPMLDEKPSWLPVNQAAATISEVVTSTSITSTPSSAEVYHVLNPYLASWSDILSGLSAAGLKFDIVSRAEWLDRLSKSNPDVTVNPTYKLLGFYQNRLGKKDERPTLEFKVGRTEKESATMRDQVKKVGPELAAVWAKRWRQSGFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C763</accession>
    <name>A0ABR3C763_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_100138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616616.1">
        <property type="nucleotide sequence ID" value="XM_066754715.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986996"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1174"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="655"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="804"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1466"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="659"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0255339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1498" mass="167497" checksum="73013E740F2115FA" modified="2025-10-08" version="1">MSNPTSPANAPDTSPSASNVASSSKTGHRSVRLFAPDEEDSSDEDGLIGVPTETTFKDEEIPPANQRSASYPGPPAHTSPTSKISSIVSSASAAQPKLARTVTYVAPNAISSRPAYPLIPTGPETSIHASYETWRKTRYTLEPYSRGHKPDGKHAAQRGRSYTDPDIGYFSADGGDGAWGSDDEDELRSPGWGMSHHNMDSGGKTDGSPQLPIKPADVTEDEGQERLDWQGMLESVLNSDVLKVEEQRIYNSMPTDSFREEIGKTLWWQIRAKLRGRTEAEEKKRVQERRARVVDPVLEEVNEFKYDPNINLLEGEENGDADPHDPTSTATPQSKALSQVNTILAKLHAVKGLYPNLAAMRADKALYTNEEFRKRADALTSWSIIVTSLQTQLKLLQKWTGSDELDITKPNTTHEKALVGKHKYHSMDSNKGTTPGGDAADDSSFLDRVIKEDNLQRTFERRAFVDMINLVRNAKETVINYLPQFQQQNLPDFQYEIVRLIGFPGRLIIEAVKVRLDAASRLLDPNPMVVEDFIENLRLSISLAVLIRKQYDEIMAPDPERRWKIPHCLPTEYNDVLLDALRTFFKLLHWRLRGVGKASYYKETEVLEEEAPFLYEAAEAIVGGDMVVAEQYCALSNKLLIRSANYLDQQLRVPLQSTSRDKEQRSGGDKERDGSSSAQRGDRDRNRDSSLPAPSKYMTVEELFSWYSKLLDSARMRHRKTQRFCRKLTQRFDNSAEYSIEETDVDMLVETLQETGHFLVYTGKFEAKGTYIVADGSLWGQPDDVRHLLKRVFSVTIPGSRVRPRQVTSQVSGGGGGASLSPNGQVAAHQHNPADPYPEVDDVDDEALATYILLISPRQNFVWSGAVMTLNVDYTEYDLPDNRVRLIADGPTKRLALCKHYFAQALIHPDTGEKVDLPCVIEAQAHLPTIQKQLVKIAKSSYRLSECIVQSAPLVRNAFRGKSGSQELVENWYSFATEHGTRASIHVEPNAWDRFSRLLMRLAISWISFISQECNPTDRKTFRWTVAALTYAFNMTRGSNILALDRSEFSLLRRYVGVCVSLLVSHFDILGARSSMEAKKEAERIEAMRRLQRLQENLDDEFLPRTPIESGGQPRIDRSIRLTVEERLRLIAELEARRSELATAPVGQVLDEEVSEDRALVFLAASKSNISMRWQQGAYIGGGASGSVYLGYSLQDNTVFAVKILPTVDLQSSPALYESIKRESDVMSLLSHPNIVGFLGLEVHRNRVCLFQEYCEGGSLAGMLEYGKIDDEEVIGAFTIQLLRGLEYLHANRIEHRDLKPENILIGANSVLKLADFGTAKIIKSNKTLARTRGGGHAKMEGLEGTPMYMAPEMIKNQRTGKLGACDIWGLGCIVLQMVTGSKPWSFLDFDNEWAIMFHLGATKEPPPLPNPNEMSDQGIDFIDQCLSLDPEARPTASELLQDEWLVPMLEQMAELEQEYPDVLAMTQSDSLAPPPENASLTSNAPTLQDDITPPPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C774</accession>
    <name>A0ABR3C774_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617282.1">
        <property type="nucleotide sequence ID" value="XM_066755381.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987674"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09813">
        <property type="entry name" value="3b-HSD-NSDHL-like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="320"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0256005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="444" mass="48895" checksum="0374B9E08460667D" modified="2025-10-08" version="1">MSNSPPTFESYLVVGGCGFLGRHIVEQLLARGETQVSVFDIVQRHFDSNVNFYIGDLSNPQDVENALVKSQATVVIHTASPTHGMGRALYEKVNVTGTRTLLDAILSPSSTVSKLVYTSSGGVIYSGKEDICNADERLDYPAVALDAYNETKVAAEKMVLEANEQEKGGEGGAKLLTCAIRPAGIFGPGDRQMISGFYSVVKNGQTKWQIGDNTNLGDFTYVGNIAHAHLLAADKLGSAYPYHALREPLPAINNTLGTYRIPTSAARPLGPNEHPTQADSLAAKRFESGWVDETDLRPVLRTKMDQFSAEAQKEEGEEGEGIPIAGQAYFITNGEPIYFWDFARTIWRQLGHVPPYTIVLSTMIGLILASLAEFFSKLSGKEPGFTRFRVSQATQQRFYDIEKARRLLGYSPVVGMEEGMKTWTTWYKGELEKQNEVQESEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C7I5</accession>
    <name>A0ABR3C7I5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616736.1">
        <property type="nucleotide sequence ID" value="XM_066754835.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987121"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046502762" description="SUN domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="64"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="561"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="667"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="752"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="695"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="813"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="836" mass="93766" checksum="EA9450661D7E5282" modified="2025-10-08" version="1">MRILSWLPLLVLPLPLAAAAPSTPADPWALFRYQCPPSPSPPAPPPAIVGFEEWKRTVAPANNSSRPPPPPDNKPPPAPAQHPPPPHHSKYNYASPDCSARIHSSSPLTQHAASLLHKSRDRYMLTPCRASEHWVVVELCDEIRIDAVEIAVWEFFSGVVREVQVSVGGEDEDGQADGGGEAAGRGHVWKQVGSFIGKNVRGSQTFTLSQPTSFHRFVRLDFPSYYGSEYYCPVSSLKVYGMNQMEAFKWEQKQLHHNREKEVFREEEQVRRAKETQEREKKERERDERDKQQQREKELDELEKLLHEQAGRLVPELLADGLFTEEATGVASTTPASTLIREDEQRDDSSLPPTNDSLAAATPISEASTTSSSTTPVYTRPRSDSSESIYAFIIRRLNALEGNSSLVARYMEEQAKVMRSMLKRVEVGWDEWKGEWEDEDRGRWQQERMRQEDRLGRVLSQLEQQRIAFDAERKSIETQLRVLADQLGYERRRGIAQLIIMLIIILLGAASRSSTINAILTPLVTEARRRQSDYYHRKNRSGPLAGLHIDMGAGRPPAVIGQARPKSPSAHTHTHTHAQTPTHRRVPSSTSTPRLKTSLSRTGSAHTSLKRRSVVPQVSIPVPSYYRSVSSSEFTFPPPTDPAASASALALASPPLVNVWTPRTMRGSVPLSPPPPPASASAAARKAAARSAHLHMMETGDRDRDRDRVRPGERERIYQDIPTPPKYHPTSNTSLLLDLENVGMNTKRRRRLRSVLNSVDPTPRKDVYNDEEEEGERERMERVAGDTSQGEWGTDDFDTETSAASGSASEVEDQVRQDTKEEAMDGDTEQRVREKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C8G3</accession>
    <name>A0ABR3C8G3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ferro-O2-oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_100854</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617318.1">
        <property type="nucleotide sequence ID" value="XM_066755417.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987712"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046067248" description="Ferro-O2-oxidoreductase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="29"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="160"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="407"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0256041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="70275" checksum="9E8B057E97B56FF6" modified="2025-10-08" version="1">MTLISAFLATIPLLTQAVSAATIEHWWNISYAVANPDGLFERRVIGVNGSWPPPPLLATQGDTILIHAYNGLNDPNIGTALHTHGISFNGSNYYDGAVGITQCSIPMGEMLDYVIDTNLQAGTFWMHGHYLGQYVDGLRSPLVIEPQNATGRSDDVTWDDDYTLVVSDWYHRQHLDLLTNDFLTWENPTGAEPVPDSAVIYLVKDGKYYPSAESVASGAAVNDNLSIPFEAGKTYKIRVINMSALAMFYVALDQHDISIIEVDGVEVEPYSVDALPLSVAQRYSILVKAKNETDRNYAMTVMQDVGMYDYLPNELVLNNTIQISYSSSNSPADEVTYPGEFQDIDDTLFTPLLRIAMAPADIEYTLHVNFDTYDDGTNRGSFNNVTFQEPPTASIFTALTMGNASLLPSVYGAQTNAFTYPHMANIQLTVYNWDAGSHPFHFHGHEFQVVQKSFDVTDEEDEGNGEIVEGQDNPMRRDTITIPSTGKVVLRWRADNPGAWFFHCHIDWHLSSGLAAVFIEAPEKFQESTVVPQTIVDHCKYWGLPTSGNVVGLNSTTNFDGQPWGPFPLVIGWTPAAFTSIFLCVTTALIGIATVIWYNQDTLDSRDMEEHIRRKIEAKKRRGGLLRRLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHI7</accession>
    <name>A0ABR3BHI7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610687.1">
        <property type="nucleotide sequence ID" value="XM_066761147.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993580"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047011407" description="Cell wall protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="24765" checksum="D49A29D4ED85803F" modified="2025-10-08" version="1">MKFSALTLAPLLALPLAQATITPTSPDGSTTVKVGDTIEALWTADSTDGWTDVEIQLMTGDNLAMVPLAAVATGIDGTSATSFSFVAPDVSPYSKIYFLQFTNGGNMTGATWTTRFTIAGADGSTTEPTNSTDFHGQTVEWGTGQLLSSVSSSSSNSSSSSETNSTSASAVAAAVTASASSSSSSSSSSASSESPSASSASSESDAASNSTTHSASSANASSGSSTSSGSRVQVGLVSVFIASALGLAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHQ0</accession>
    <name>A0ABR3BHQ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_106786</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610745.1">
        <property type="nucleotide sequence ID" value="XM_066761205.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993639"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="281"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="359"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0240237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1955" mass="214641" checksum="DFA24C0211FD5827" modified="2025-10-08" version="1">MFSLPSFLTAFSFTLPSLPSISLPANIQRRFLSYVLKRTLGRFVSHQALDAERIQAQVSEGWVEIENLEIECIEINSYIPPSLPLSLTSGTLNKLTAKLPFPNLWSDPLQVSLDTLTLDFTLSSPSPLSRGGTATRPEHHDLAESVTSAADDFLHHELDAYEEKELEGSIRQSLILSQADPFISDVPGGFPLGSPGEISPGQPLPVNMESTTVLAGMVERILARLEFRVEKIKIRLVVEDEEGVVELTVGTIQYADESESQTNDDGKSTTRAIRISNISLDIVPSQPNPPLVIPQRQSREPSVSSSNSTISTSPGHDHSDMFLSQAVFDLRQSLLAPGQISEPANEQSVHESNMFYSAMSQPDESEPDANTRTKRSGISWNPESANEAEEGLGSATPTETKPQPSSIPVLSFGQEDVILRMRTTRPLISVEHQTSFNNNKPAVEVNISIGTITTVLLPSHLKLFISALQTVQALSPEENIPTAKDKLAQSASPQTRLTATTKLKAFYLSLVYDLSAETSINLHLTLASHLTRPTNPLPYSHLRFRLDTLVASYQSQGHYSPSCTASTRTTSSMSTANLRRRSSGHARFGSPPPSLTVDVGDISFFEWMGEGMTAPIILFDPGLKRQYDLPSPAPHQGQQGFPGFECKDWREGKKTGGEKAWRVRPRSKGILKGEAREITEDEGPVIHVRQDLGSDSAAVVNLQPLHVFVDLSLIERLLPILRSVTPLIHPPEPTPAWLQSAQSQSIREEVTPESIISSLSAPPPPVRGKKMKADIRCGLVRLSVRCPAPPPEPSERQIGDGCQLRSGIICVNVHDLRARFMDISNTGTEPASSEIANVEFEQTLMFFASASQHYAHPFLIFAPLSPEPGEEDIPLLPSISLSSLPQTSSLTASSIAKTILVICKIPAIRASVHHPTITGLQYFADDVTRWLDVAFADGSAKPRDELKMIGSRFFGGSKGSEASSEVDELYDVEQVAGGMKIEIEINEIDMGLFVPRLDGSGEKIFNFKASDLGVQMETHPERNETVLQLSIMDLDFSDVSSTPLRILGRTTPFTLTAHQAPIVYLQFVSSTDLLTTLKESNISIVLSHFTFAVHKEITWLHEIAEFAKPPKGVFENLSPTDLTRLSISLSSASFLLVPPNLPGSIVILVRGVEGKTEIPKGATDSILEVGMSGLGVLAVEGESGPLEVAGDLVDVWKKAGYAQLAEVMVLELQLTRELVGAGEVSLDITQAQFKVTACADSLATFAEMATDFGRLFPNKKEEYVKLPSMGQSINVFDSLDENVFNLMPEIVSHSDTDMIEDDLPHNLDYLDRATRISKHYPSMDRTTGESLRAWQTPGEDLEEGEWGNGESGETIRTFNEETEEEEGYWEGLPVLNDAYSADQKPGKIRIRVIDASLKIFLHDGYDWSRTRKAIEDEVRAVRRRLERIRQLLASGQKADESIENATSSVLFNSVYIGLEQKGEMGLSRMGMGKMDEKALIAAIDEELDEMETGSTSSWQTLPAGIGAGPSAVHQAHKKTRLKGKRLTRSKKPQIEINLLGIKADVDLYPTEEPTSSRVHFTAKEMEILDHIKTSTWKKFLTEMKADSRGNIRETDADMLRIELVGVRLKEDEEEMRLRAKILPLRLHVDQDALDFLKRFFSFKAPTTTTAKPVSQKTTSSTSGLYFQHVEIFPIQLKLDYKPKRVDFRALREGKTIELMNFFHFEGAEMTLRHITLSGITGLERLGTTLQDLWTPDVKANQLADVISGVSPIRSMVNVGSGVADLILLPIEQYRKDGRIAKGVQRGTNSFVKSTALEMMKLGARLATGTQVILERAEGVLGGNLSKDVIGQVQGLSANDFGVGSGMTEGGSSSEDEQEVISRYANQPEGMREGVQAAYKSLSKNVNAAAQTILAVPMEVYERSGDDGPLKAVVRAVPIAVLKPMIGTTEAVSKTLLGMRNSLDPSARRELGDKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHX5</accession>
    <name>A0ABR3BHX5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_106563</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610812.1">
        <property type="nucleotide sequence ID" value="XM_066760987.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993418"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="211"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="261"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="308"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="479"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0240313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="61276" checksum="D3E68818ECE1FFC9" modified="2025-10-08" version="1">MEGFDLPLSFGKKSKAGNTNLKAKVENTKRADIPTLVKEERAEREVPVPSVSTTGRVAEADEEDNDEKIGPIPPSTTGKRKAEEESDTSDDEQEAEEEVDKLPISHEIILKDHTKVVSALAVDPSGARIATGSHDYDTKLWDFGGMDHRLKPFKSFEANGNYYVHDLSYSPDGQQLLVISGTVQPKVFNRNGEDETEFNKGDVYLRDMKNTNGHTAEINAGAWHPTDKSIFLTCSNDSTLRIWDVTNKRKQKQVIVVKSKERGARTKVTACAWSPDGKWIAGACLDGTLHIWDTSSNFARPKYSCEIAHPKNTETTGVAFSRDGLRVATRGGDDTVKLWDIRSIRNPLAVAKNLDNLYPETNLIFSPDDTQILTGTASPKGQKGGLVFLNSKDLKEERRIAIGEGSVVRVLWHSRINQIFATLSTGGVHVLYSPHSSIHGALLPLSKLPKTAPRDPSFSTVDLKPVIYTPDALPMYQEQGHRESLHQKEKRAKKMKPMEPVSGVGKAGRLGASETQSFVHSMYPETLKFEDPREALLKYASKEEQEKKKQEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI20</accession>
    <name>A0ABR3BI20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610850.1">
        <property type="nucleotide sequence ID" value="XM_066761025.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993457"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13437">
        <property type="entry name" value="SPFH_alloslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="115"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="377" mass="40395" checksum="FCA5BD2470A1C1FD" modified="2025-10-08" version="1">MSDSAPGHSKSSMDGTTINFNSAKGQNEPLPIPENNELDRYVTDDLPRQPRMAAKPQVPDAIMAVQPLRKNEMQPSYAQDLGTSTIEHGFYGSMMNALGECIGALGMIPCCPCPNPFHNVSQGAVGLVSRFGQFYKSVDPGLVKVNVCTEDVRVVDVKIQLTSVPRQTVQTKDNVSVEVDSVICWHVISPYRSAFGINDVRSALVERAQTTLRQVVGGRVLQSVISDREGLAHEVAEIIETTAEKWGVAIESILLKDINFSVELQQSLSSAATQKRIGESKVIAARAEVDAAKLMRQAADILASPAAMQIRQLEALQNMARSSGSKVVFVPMNLGTMGAAGMHDVAHQIAASGHDERTDTGPGSATNAGIISSMAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI86</accession>
    <name>A0ABR3BI86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Asparagine-linked glycosylation protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610909.1">
        <property type="nucleotide sequence ID" value="XM_066761084.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993517"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="55641" checksum="597332AA9F7E4666" modified="2025-10-08" version="1">MFLFRFVSLPIVYLEISHLSVMSQTRASHHMTSGLLHPYLDRAMKPVCPKYLYPLFIGTQMIVFWAITLVHTRMYQEEKPHVHQVERFAQGEFDYHDEDLHTPIIWHFFVSLPFYLLRATPTLSTLRLISLAQALILPTVITLVTNPTPSPRPLVFQRVIDAIRDPSDFGLVCGLNPLAILMAVRFTPGLSCLLCLLILWRLSIKGNHWIGAAVAAGIGLLRAGVMFWVIFVIGWTAHEISVSAPQKLATTNYYPYLFTLAVWMGFWSQQPIQFQWSGFYDIVSLLFLRFPITPVWDIYSPIMLFKRFRWTGLWALTTLFTYTVSGTTINNQVILVDQCLPIFILRLYLLFLQGKENAEWQERRMEMLEEGRGEVRLEGTGVNGQLPDVTLYTYGQHANQTEAEASNLPEQREEEHESPVGLNTGEEQRTAVVEENVSESTEDIEVEGQEPQQRVQEMHIGRIELGWYLLSITLGALIILLVGNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIA9</accession>
    <name>A0ABR3BIA9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (Uracil-5-)-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610928.1">
        <property type="nucleotide sequence ID" value="XM_066761103.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993536"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="65543" checksum="59C0B209AB355F83" modified="2025-10-08" version="1">MTTSPIRSPPAKRLKQELPADFTHITEAPVNALFTEPSKSQQPKKQTKRDRRKGRKPLPEPFSPADVMWHDVRDFLGRDYVDEVLGKKDGGEWEAPNELGSFAVVELSAGAFTVSGESLSLFQSGDKKWAIITPFAHPGDRIRAKIYKHDRLHCLADLVEILEYSDTYRGGEGDRRVNPDGGCKYFGECGGCQLQPVPYHLQLQHKLRTVQLAYERFSTLPSSLVPTILPTIGSPKQWGYRTKITPHFDAPPKWAKEKLTKLQAEAASTGEEEALNAEDEARKGWECRVGFERKGKPGVMDIEECPIATSVLNTQLTLSRAQVKSSIMSYKKGATILLRDALPEPNPLPTAENPWNVQEAGEEQHIAVTDHKAQVYERVGPWLFSFTAGSFFQNNNSILIPLTTYVQEAIFPPNPKPNFPRPTHLVDTYCGSGLFGVTLSPSFTAVAGVEISSISIEAAKRNAEMNGLKDKTTWLCGKAEDIFGGLAEQGFAGGHSCVVVDPPRKGCDTPFLDQLLNFRPLTIVYVSCNVHTQARDVGYLVHESNKRGQASQGKEEAVKGWKYTVESLRGFDLFPQTAHVESVAVLRLEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIL8</accession>
    <name>A0ABR3BIL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611006.1">
        <property type="nucleotide sequence ID" value="XM_066760734.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993156"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="112"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="195"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="477" mass="49383" checksum="E197E0AE50D87094" modified="2025-10-08" version="1">MTEDIYKDDLYGDLDLEDLDASQLEELVEPPELDTAPTSTPAASNAAAAPSQPAVTASSSTSAPVESGSQQYNHQPSYDATAPYQQGQQDSNFGQQQDGQDRIKPSDMPDEGKMFIGGLNWETTEAGLSEYMGQFGEIDACTIMRDPSGRSRGFAFLTYRDPASVTKVMAQTHHLDGKQIDPKRAIPRAEHERTAKVFVGGLAPSVTGESLKSFLCQFGQVMDATVMFDKETGRSKGFAFATFQDEESVGRAMAASGVELEGKQIEIKKAQPRGTAQGSKFGANMNPRFNQGAGFNGGMGGFGGGFDPSSVAMMYQNMMKTGGNMMGGFDPSAMAMMYQNMMKSMGNAPAINPSLAMRNNAGGAAAGGAVGGAMPMGMGMPGMGGMGALGGMGGMGGMGMGGMGMGGMGMGGMGGMGMGGGMNRMGNNRQIPNAPRGPAAMRGPGQQPMGGAANAPQGSGPGAQRYSTQGNARARPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIU6</accession>
    <name>A0ABR3BIU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611120.1">
        <property type="nucleotide sequence ID" value="XM_066760848.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993274"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="223"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="423" mass="47662" checksum="E25A54836D063121" modified="2025-10-08" version="1">MASDTPTSEKLDQAASVFDKDPTTAGRLYKEILQDDSQPANEDVLRDKEVALVKLGTLYRDSSMLDKLAQLITDSRTFMSHIAKAKTTRLVRTLLDLFPQDSKDMQMKVIQENIDWARTEKRVFLRQSLEIKLINVLLDAEKYQEALTITQTLLKELKKFDDKIILTEVYLLESRAAHHMHNHPVAKTSLTSARTTANSVYCPPTLQAQLDLQSGVIMAEDKDYKTAYSYFFEAFEGFSQAAERDNRALSALKYMLLCKIMIGTPNDVFSLLSLKSAAPYMGKDVDAMKAVATALEERSLDLFKTALQNYSGQLQKDEIIRSHLSYLYDTLLEQNLIRVIEPYSAVELSWVASEVGQSLQVIEDKLSQMILDQKFCGILNERMGTLEVHDDYSNEGICSTALGTLKHISDVVNGLNDKAAQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJH1</accession>
    <name>A0ABR3BJH1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611131.1">
        <property type="nucleotide sequence ID" value="XM_066760859.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993285"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF142">
        <property type="entry name" value="FAM86 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="574" mass="63045" checksum="C4FC23E61C7114F7" modified="2025-10-08" version="1">MSIPSTFLPHLPRSQYTLQSLNPTELLSHIALLRELYLPPIHGGFHAADVFDDEDESRIDASEESKKKGRQVKKEIIEIKRKRRFSAGLVETMEGMGLGLDVELPANPETIIEDKFNEEKEDNEEKEDIEVEYEEELETPHLDPFEREWAEKWLSGVVRRAQGWLEENEGDEKMDKIKETEAILRDATAVLAMMAGTSAAGSLTRHLVFPIADYLGPALSQIRSKIIPNPMHSPSTTTFLASFSTSPTSPITFRTRLPTSPTTSTSANRGERPQKTKRALLPILLHDAPMGDHLSVGVQTWGSAILLGRQIALHPSDYGLFLPSGVNRGVRVLELGAGTGLLSILCRKLLDLNAISSGSHPGLVVATDFLPSVLDNLKICVDLNFPPALTSNGIESTTDVARNEGIHIAKLDWTTFPAFMARGCQGDTEQIGVFSMDGTFDLVLASDCVYDETHAKLLREVASWVLRLPEGENDQGGTFHILSPLRPTFAPELESIDQHFPPLSTYAPLSERSATASSSDPSAVAPELRGEGLGISKGLKLGTRGEGKRGVKGRKGEGRIDEAQGYWWWEVGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJJ7</accession>
    <name>A0ABR3BJJ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611279.1">
        <property type="nucleotide sequence ID" value="XM_066760518.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992926"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1284"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="984"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1364"/>
            <end position="1393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0241897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1634" mass="175408" checksum="A3FF7A480FFE777C" modified="2025-10-08" version="1">MSANGHAPSPAPQQKKGFFRRLSLASGGSNSTAQVQPSNKLVKQNKEKETQVQGQAYEQLDTGSAQSGFKATGDMKRTKSKDRGFWSRGAKSATPTPPPVSQSSKPPVQPPLASSYGRPTAFTQLDSSLGPYPSFPTANPSHQQQQQQSYRQQPPFGGFSQEGPYPQIRQFPQPQIHQPQAQYPQTQHPQLPQQMYKQQAQFKPFRTPSQIRAPVHPALASSPSPVLNTTTSPAQRVNPTGSGAVRSPYGSPQDGRAPGAFGGSVLGQEVGRPANGREEGVRKARLNGEEVRAPPQLQPINSAPRSSSRTYPDMRSPPPPQPLTSPPPPVPNTPSGEPSMPNLANVASHNPNASSNSDGSWKTMMPNAGARAGAGAGVNGNAGVTHTRERSGSLRPQPPPLIIPSDPRQPQAQAQSYPPVRPSSRVESYSRPQSQNQPLTGTQNVQSSQSQSLSQPHAQIQGQMERSHRAEQKLQEVQRGRNQNRDSRFEDADHFEIPREAPPAYTPSPARERVVSPVASLSLPPGAAPAHVGGQSSHVQQPQPQPQLQQDLATAAARPREPESQRQPQPLVQSGPSTQSHISSQTPPRPAPRKASSSSPTVPTRATQPQSHPQNYTQPPTTPTRPRSETPRRRDGDGREPMSEASKYARAVAVAMRSDSLSSSDTGARHVTVTSRGVGAGAGVWDFAAEKPSTPSKMERLHTPRTSLSSPVGSEQGDGSPRKRPLPHVPGGGSSMGSGVGMGQRGSMIVPISSKALPQVENQVEKQRTPERKLGKEIRKEEPPIIREEKPLPVEKIEKEAPLPLEKDSLRPPEPIAKSPKVGRPVSQTLAFEFPRSPTLPPLVDPRNAPPSSTTSPLATPAHQGSEQEHDPISKWTAGTEKSDETTKTNGTPLPPLWGGDALPPRKSSIQGLGVQSGLSQPPPGKRTVSSPLSGRSSPMFMSPLGGMSSPLVPSQNSSQYSRQGARSVSQPLPTLPNSSSIPTLPPLLPSEPIPELAPRGPRPKATITFILAYSSIQAALLPYLSINSFLSLTGSSEQVRRRFTGEMVGRWVMREWGMGVARTKGGAGGKGGWPNLTVWEGFLESLLHDPASFSTYPAQWYSLLQHLCLSHTLVTLHLRSLPNNLFPNPPPMAFEDDFALAAPHLPFSSSHNSLSNQGRPRSRVSSFAGSDAGSVSGPGGALKMPKAERLVEIVMPEPLAARSADEADSPSSRRFPPSAASNRRRRGSNGSLTSTVSMPFMRKRPSNSAMSISEMPLHLSAAPMPASGKANLPPVSYPSAKRYGFRRHGEPSRSRASLNDGASGRAGSIFSVASSPSIQNARMWSAASSRASFALNRNAPPASGFSGAADLPMPPPIGGSKRGSFSSLSEHGRSSQSGNNSPVDTMSKQEFYTPSPPATKRVEPAFDKPMPYSLEKAPLLRVFVPLTEIVQKWPSVEGAAAAVRELEKCGAMRKLKLGDLIINTAIRAPKTTEHVLIYVPFTQHLLLPLSYTFSPTGHLPPLVNALQLPPSYYYPFLPTPQIVYLDLAPFGEEALASLRLAYDRRDMIVASGARVSAKRYLHVAGFQVRSGDGAEPGWEGFVSLESEGTAEGKNDIEKRLVGARGGRPIVGPWEVVRDKCMVGNIWLKLVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJU4</accession>
    <name>A0ABR3BJU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611442.1">
        <property type="nucleotide sequence ID" value="XM_066760681.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993103"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="120"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="515" mass="53526" checksum="A0689B8512F49419" modified="2025-10-08" version="1">MVSNNSLHRLFSFGQSQAGDWQPYWPTHNSKSRDEGMIPNQQQSVEQDDWEIDTQEVPKKLTRQPKIANPVGYAPDTYSNAIPPSQNAGPTYGGAAELAQANRGVGDANEDDDDWFRGDRPTTNRQIWDSANARSSSTTIIAPQALPTPAVQLLRRTPNSASSGSNSPSNGVIGEKKGKSMEERAEEYRLARERIFGTAADPAASDASSPSVQGSAGQNATTPSCSTSSPSAFAKLSLNPSDKDRRQDRRSISGNGRQRGRNPSGANAGNNNNSNNSSNSRFGGNGGVTGNGRERDGSYSSYTQRDGSYNRFPADTPRGLSSAYTSTPTSSSSSSSPSLSATRMTDRPFAGLVPSQVRTTLSPNPTNPANVINPTYPIYPNNPMGRPATTGGNGNPGIRGGEYSSSTDMTPGSAAGPGLATGAQGGVVRQPLGPGAGQAEGFGIEFGGAGARIGGEGSLGYGNGYGYGYGYGYGGNDDRSASAGGNRGYGGNGINGSGNRGAEANYSPGFRNARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJY2</accession>
    <name>A0ABR3BJY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_106412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611113.1">
        <property type="nucleotide sequence ID" value="XM_066760841.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993267"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0240614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="364" mass="40599" checksum="8FFBC08C75CAA4A1" modified="2025-10-08" version="1">MTEYWVSKKQYWCKYCNIWIRDDAPSRRQHETGLKHIGNKERFIRDLYRGGEKAKKEKSQEAAEMARIDAAAAAAYAHDAASGAVRPSSLALSSASPAPSSSMAKARDSRPKDKFSNYSTAAQLGFVDPDAEKSTYEIEQEIKGRAGEPGQWEEVVAPPPLTEAYSTSINGAKRNREEEDEEGEGWKFEHKGKKPVHDPYDDDWDPSSLKGLKVKKMEETLFGGKRMKVEGEVVKQEPSTQVWQQVQPKDEPGLQKEGWTGKIELKPKMKESDKVFIPGGGWVKVEKSLAGEVETEGSETAEDAKADADMKKLEKEASVETTAVTNEAIKEEPDLKPDISAPEPTASGESMFKKRRPPPLNRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK15</accession>
    <name>A0ABR3BK15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610914.1">
        <property type="nucleotide sequence ID" value="XM_066761089.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993522"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047404212" description="Ricin B lectin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="3">
        <location>
            <begin position="34"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="209" mass="22369" checksum="1303A3B0C568F10B" modified="2025-10-08" version="1">MIFTTLVALLSIASLATASPLPEARSLNKRYTRVQIQSYRNGECLVPEGAKWGNGFQVITKPCYQATWWDINPGSGSILLSGTSMALDAGTGTENNEIVKIWQSYPGLFQQTWYLTPDNRIAITGGDQCLDQGDNGPQTYQCTTGNTNQIWYIIEGGGSGSTTTLPADGSAATTVSSSDAPDPTTSSAEVSALTSDERIMPDEATQRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK31</accession>
    <name>A0ABR3BK31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PH-response transcription factor pacC/RIM101</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105773</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611526.1">
        <property type="nucleotide sequence ID" value="XM_066760222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992628"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="157"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="628"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="686"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="889"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="751"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="776"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="798"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="895"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="906"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0242144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="916" mass="98973" checksum="8451D74D559769ED" modified="2025-10-08" version="1">MAYPTLPPNLLSTPNTYSDSVSPSDPEPITPELISREPENSAQKVAKTAVNNTSASSKSTDSKGEALPCKWTGCSHISESPDELYDHLCTIHVGRKSTNNLCLTCGWENCGTKCVKRDHITSHLRVHTPLKPHPCAVCGKTFKRPQDLKKHERIHTAEHHQLHKLSKAPTTTDPEFNSRVSLSSATRTDRPRSPLSTSVSPTSTSSHSLHSSSSPFDHLLAAGFHTDKSVSPTPSALALLHKKQHEELAAYQQKEMLVLQQLAFNQQQSQAYAARLAAEPYNAGAGAKRGQVDAFHELLSDVKKRKVEPVYDQDMIHRLNALVPPALPTSFPALPSLGGYNQYRTFPSFGGYPNLPSLHTGIYPTIAPQTQYSNQSPLPIPEIKTEADLAMFNEFMISLGRDAAANKAGPHPMTQSASGSGASNGYSASNSGTPLSETSGGVEDLFNAEELASLGLAGMPGISVHSGDLHNSNDESTHSVSDASPPTVSFGGLYPSLEAMRNRNNSAPDLSALPSAAKRPIAGLPRGSMGNVHGASVNQPTKPSYLSGMYGFNSSQQYDETTHDYLHGLSNGHHNDYSHSANNGATNPYASFDSLARNKQSLPAATLAPKMFHNKVYRDVAPLGTAVSKRARESAERTNMEDSDSEDLYDQSESSHGYAVSNERVREERTPKIPVRSLIISTRALSPSTASGKEDDLKLPAISPSHVEPGTDLPPLHSIQGGHGSGLYRRTSSLSSNSTSTSGSSSFNNSLAPSNVASGTTTPRGSTPLRGVPTKRHTEDEIVRGVKRLELGPAEPLRSTTPELVDSATTERAASAERDQKPDISALSSSSSSPPPSGNPLPSISTAGEERKGITMEEMRRRHAALIKSWLVAVNLQWRRTKMEEMQRKQREEMEEREEEEEVMNVDERERVGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK72</accession>
    <name>A0ABR3BK72_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611561.1">
        <property type="nucleotide sequence ID" value="XM_066760257.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992663"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="9">
        <location>
            <begin position="137"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="417"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0242179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="463" mass="50866" checksum="E688A96814B6E88C" modified="2025-10-08" version="1">MARAITSAAPKCERSASSPLTDLEPEVPTLMAVKPKRAVRSTKTKKEEDKEKDNGEDEPTPAKKQRVSKAKAWPPAELEPMLHLPRQGYPAFKLPSSTASPNGGIAPPNDGSQPMLLGAHVSAAGGPATALLRAGLAGANGLALFVKSQRQWKSKPYEDDTMQRFKELMKSKEEGGMGYGPESILVHGSYLINLGNPDPIKWKVSYECFKDDIARCHQLGIKLYNWHPGSTVGACTKEESFALIAKAINQVHKDVPEVITVIENMANAGSNIVGTAWSDLSSIIELVDDKSRVRVCIDTCHTFAAGYDIRTRETYAETMRKFDEVVGNKYLAGVHLNDSKADLGANKDLHENIGLGKIGLTAFRCIMRDPLMAGIPLVLETPAPDSPIPAEHLSIWTKEIALLYEIQAIEDEEWEAKKGEIEERWRKERDAINPPKEKKKPVARGKTKKAQKAEDEGCSHDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL08</accession>
    <name>A0ABR3BL08_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105747</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611500.1">
        <property type="nucleotide sequence ID" value="XM_066760196.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992602"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0242118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="263" mass="29720" checksum="A879A28025DB616B" modified="2025-10-08" version="1">MDNNRSSTSKSNQAKQPKQNNPKNQPQTLKQPVQPQILNKDLFQRINYTYQAAIFLQNIGVDAGPSSSRSKRDGDVHVVMDRKGKRRAVERKGDQGAFKKLTRMSMRETKTMVVHNQLKLDPSLKRSICRVCSTVLIPGLTSRIRNRPNLNTFNKINQTCLTCFTVLSIPSPPVALHNDPTESAVTQDRGSLDGPVRAARREKIARRSKPAFHECERQDEGTKGHVLWRGEEKLGKWGVYKHVEEGIVQQSDAEDRKQTTPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL96</accession>
    <name>A0ABR3BL96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611937.1">
        <property type="nucleotide sequence ID" value="XM_066759991.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992392"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="2">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="559" mass="59860" checksum="D188E5E87A5CFF12" modified="2025-10-08" version="1">MSSLASLPSFIPQQPSPESAQPVTSSCRISCLPPPPTIPFAGISQSEQRYLYFGVRRGFVSGVYTDWKEAQKQIVNHPEPALKTFSTRLAAEAYVSGWDGAGRHSLPPSTPRPLREHLAMSFPGSVNVQAPGSQRRPSYHARLLAASSTELGSLALDTSPSPIRPGLSSRSSYRSSTVHISSPLRQQVDDESDDSNGEKSSTDNKHRSLRKAANYVGAGGLLSPPQSPERKAKRLGDSVMERERPTQRRALTDSKTCSSRTHSEFPAQSGSRPLSPPTSPINRSHTRRPSDYSKSSLWADSVPQPEPVTPESPQPDFADPTIPKFSRSGLRKSGVVMPVAAKRSSSSLSLKSRGSLFSSSNDSSSSIGSSSSKRSDKTMRRPSHSRQPSSSHLSKPQFSSLDRLATLAETSKRELQLNDEDLDAIPSLSPPRPAFMRRVSSASSIGSNDSFGSMGSMGSMTSGSSAQTSSLESCEPIVEEAEPDVHIQQSKDNESIPEHALVVVSGTCTKSDGDASVDSGSMKHVKAGKSKGGGMFKRLAKVLGLEKKKSVGAGRRGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLG9</accession>
    <name>A0ABR3BLG9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105609</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612008.1">
        <property type="nucleotide sequence ID" value="XM_066760062.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992464"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF62">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="82"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0243641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="511" mass="56368" checksum="5AC9DCCFB17DC237" modified="2025-10-08" version="1">MSHLDNHGIAPAATNVINPPAGGLKLTQSRTNSINKVCVDHVEDVEKIPEDHDANIKADQFGTNTEYSKEERALLRKLDWHIMPIVFCMYFMNKLDQNAIANARLNHFEKDLGLTGNQFNICVSVLYAGYTLIQIPSNMIMATKKIRPSIWMSCWMMAWAVVSACTAAVHNFSGAFAIRFLLGFAEAPFYPGAIYLLSLFYTRREIATRISILYSANIIATACAGLISAATFATLGGVHGLAGWRWLFIILGVVTFGISIIAMWLLPDHPRTTRWLSPEEQELAHFRMEQDTVGLQESKSTLAGLKQAAADPKLWLLTLLQTLHLAACGFNSFFPTVVKTLGYSTTLTLVITCPPYLVAGIFSIALAWSSGRRNERSVHITFGMVVALVGFIMAAASLKTAVRFISLFLFATGAYSANSIIIGWVAATCGQTPEKKAGALSIMNCIGMASFIYTPYLYPASDGPRYLMAMSANAAFVMGVIICTWIMRFWLQQVNKKLRRGDATTRLLYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLM3</accession>
    <name>A0ABR3BLM3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_105972</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611725.1">
        <property type="nucleotide sequence ID" value="XM_066760421.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992827"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0242343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="66" mass="7640" checksum="18B2D54D3FE1F2CE" modified="2025-10-08" version="1">MPGIQDVIYNTFFRRNSVFVATTFIAAFSFSMGFDLATTAFWDSHNRGKQWKDIRHKYLQGAGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLN9</accession>
    <name>A0ABR3BLN9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-catenin-like protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612077.1">
        <property type="nucleotide sequence ID" value="XM_066760131.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992536"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="7">
        <location>
            <begin position="95"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0243710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="644" mass="71696" checksum="25103826EDBC3F5D" modified="2025-10-08" version="1">MDIDKMFKLPALPSGGGNKRKMGNLPDPETLKRYKPSEPQSASETMPPPLGGLNGKGKERAVTVEDEDIEAEYSRGEDVYDGEDDEEGRFFGGGLNREQEQILDIFDAAGEGEQGPTLDLPALRRQIGKFERVVLKNTEQRGKYPDDPSKFIDSESDLDTSLKAFLPLTQNPSLFYPELVKSSIIPILANLLSHENTDIAMDVVEVIQELTDEDVGGEVDDLENEEETGSKTRMAMGQLIDELLNNSLLDLLVSNLSRLDESEDTDSQGVFHILGVFENLLSFMPPLADQIVEETALLQWLLQRIKRKEYDSNKQYASEIMAILLQDSRANVLKLGELDGMDVMLQVLSQYLKKDPGDSEEVEFMENVFNSVCSSLAQPEMKKAFLNNEGVELMVLMMKEKRLAKTRATKVLDYALQTESGSPACERFVQALGLKTFFSAFMASASSSKAGGKKNKSKLGAAAATSAIEDEEHMLGILASLFTNLASDSPERIRVIAKFVEGGYEKVERLLEVREAAEGRLGSVIKEIEHERKVMQANEEEITDIEETEWYLRKMDAGLASLQNADYVLAWVCMEDDGAMTHARLLLSRKNMNFKTIAAVLSEFKDNVGDNDEPDQEDGQRQADDAVNTQKMILEHLIAFLEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLZ4</accession>
    <name>A0ABR3BLZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612182.1">
        <property type="nucleotide sequence ID" value="XM_066759535.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991933"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40296" checksum="C4C618AB42ED2846" modified="2025-10-08" version="1">MPTPLSRQTESFNSSTGTIVPDRWGPARNTRSAAAAAATAAVDNEHTLSLSQSSQLTQVSNSGSSSSRALQPQSSLERRINNVIGVGGGDDGLMGMLQMQDVPGNSLAGWSFLGDSQPKISHAQTADQEHRVEDFLKKIDAETVPSPMPSDSSYDRAVHLQHPSVDSYRPSTAASWHSTPSSIDHSELYSSTDVDTEDEARSGIMSHSNVGDLGVGGMDIDNLQDVEGQRSWPTEHAMTALNTAVSPQQLYANSPIPSSTGDSVSSRRRRSNTDKAVSASEDERKRLDRLEHRRDINRRSAQKHRAKRKEEIETMNRKLYVREQRIRELEMLLEAERGKVVSLEGTLQKVLGGLGRSEGNGGPDRENGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM71</accession>
    <name>A0ABR3BM71_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105158</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612262.1">
        <property type="nucleotide sequence ID" value="XM_066759615.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992014"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="252"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="316"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="486"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0243895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="565" mass="63034" checksum="955DECA1FA18D5D3" modified="2025-10-08" version="1">MVAIDYTPDAAGQESYILCADCGTVISSANGAGLCVGCLRNTVDITEGIPKEATLNFCRGCERFLSPPNTWVTVQPESRELLAICLKKIARPLMKVRLIDASFIWTEPHSRRIKLKITIQKEVLAHTVLQQTFELTLVVHTGQCPSCTRLAAKNTWKASVQVRQKVTHKRTFLWLEQLILKHNAHKDTINIAEKRDGLDFFYTERNNAIKMCEFLAGVVPVRVKSSEQLISSDTHSNTSNYKFTYSVEIVPVCKDDLVCLPKSLARAWGNISPLTICSRVGNTIHLLDPMTLQQTDVTAPVYWRQPFDSLATVADLVEFIVLDVEPSGPVRGKYVLADAQVTRSSSTGNNTDDDGMGDDGIYHTRTHLGGILQPGDTVLGYHLTNTNFNSDSFEALESGRIPDVILVKKTYPNRRKKSKPRHWKLRSIAKEAEDVQDGTVGRGALGRRGGVDQKNVERDYELFLRDLEEDKEMRAVINLYKADVQEEGEDETMAVEKKSGSGLHGGKRRNGLEKQAQRGMDIDGDEAMGGGEDEVDDEEDFPEIDMDELLENFEELDMGDGEEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM88</accession>
    <name>A0ABR3BM88_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612274.1">
        <property type="nucleotide sequence ID" value="XM_066759627.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992026"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="511" mass="52174" checksum="E51AD5B00648EB0D" modified="2025-10-08" version="1">MSSSAAATSEAASSAVASSAAASSAAASSVASSAVATSTVATSTAATSAATSAAASSSAAAASSAAASSAASSAASSAVSSAVSSATASSSAAASSSTSAVSTASSIAAVSSSSSVSKAISSATSESIVDSPNRSRSNGISGGAIGGIVVGIIVGLTVIGLLWTWWRLRKTRGEKVPPPPKREMSYNIDPSQKRPSMMGTPYNSFSHHRRASTNASLLAPPGPPSIYYHSRQPSLYQISPLVTPNTIRSNDASPVPASGSSHSPGESPSLPPTDGNNSPSQGDTLGEKLSLTPVSTSVGTSEESEVQPSRTKSPRRPTGRSASTPAIRQQAYESVPSTESQTPRDSPHNSPRGSLNSLPTNARGSSMSSLRAPAMSHRPTSVNSLSSSRYLHLGPTGGAPHQGRPIALEMPRLLSAKPDMNGDYFNSVGVQKVQESQSFGLGLDEMGRMRRSSSRLTNSYMDLTISPTHSTFPRSAADRVTPRQLEAGQKKARTSSIQNNRLVVERNEPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMA0</accession>
    <name>A0ABR3BMA0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGT1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612290.1">
        <property type="nucleotide sequence ID" value="XM_066759643.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992042"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="773"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="810"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="921" mass="102906" checksum="9C4DD38AE9EABFFC" modified="2025-10-08" version="1">MANPIPLPTVPEDTLHYTIHLPTPEEPLTAALLVSQHVHSLLPERWLWNKDPWELKVATDGDHKLEGRMRVGDAVDDEWLVVWLLTQVSKKWPEFIISIRDTDGEFLLIEAANELPSWVSPDNANNRLWLSNGHLHLLPLSVHSPSSPHQLPDDLSFDSSIYVSETDAHRAVQTGKYLAPKEVESAVWERLKGYPEAMKTHLHQAKIYLPVDIAKALNKKPELVQKAVEAFYVRDPAQLRAASRMTHFSPSPSILSRVTLTRAAYAQLQGQVFHPPRVFGPEWNVRDSLSSDAGEGTPRNLENERRWRDLGVKLATGFEIMYREGGRKSRSGATGESVDRAEDEEYAVFLEGIRKAGWFGNEVEGSQKWKEREEEARKGYVNAKSVDIASQRPSFAYLVDNAIASCSLSLDQLVISENAPEDNDDWLQISPDELDSMMLHASGQAKRSDRQDEGQGKKKDVELTEEDGKALGDLVKKVQEFVGGQGDLQGARFVDELSDEDMDSDSDDEDLQAHKDKLEAEKQARMDNLVPTLPASDWGRKVHPSEQSHQPPVATNQLVGSSNADAKKIDPLGFISSKMRPPRFAKQEFDGVLSDSGSDSESDLPVEGTWGRKVAQMKWSEFPPVDSEDNQQARIEEIEEEDEDDQQRKAKLRLGEDINLEEEMQRRVWGGGEEDGDEDEDMAAEGEEELDVDMEDETEEFLKFSREALGINDEMWEGILGDRRARGAFVPQLSGKTKPKDELPAKLQPLSSTSKRVQFAEGKVPSKSDLQPSSSTQSADQSSTSLDSFETVMRAMDEALARSRSEPSISQPSQSKSFNKSNKKSTSSANPLPLVSQTDDVDLDAFSEDDIAAMDRELRSVLKGAGIDPDDSDDDIEEAGELDLDQKREYEMMRNFLESFKSQGGESGVVGNLFGRLSEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMB0</accession>
    <name>A0ABR3BMB0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105198</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612302.1">
        <property type="nucleotide sequence ID" value="XM_066759655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992054"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0243935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="567" mass="61399" checksum="105EFE3DFD3FB476" modified="2025-10-08" version="1">MAMPGGMPMVVMNTGPERQSGRKAQTANIVAAKTVADVIRTCLGPKAMLKMILDPMGGILLTNDGHAILREIDVAHPAAKSMIELSRTQDEEVGDGTTSVIILAGEILAYSLPLLERHIHPVVIIRAFKSALNDALETIQRISIPVDITSEAEMLALIKTSIGTKFSSRWSDLMCKLALEAVRTVAVTAEAENGLVGSGEGGDKVNIKTVDLKRYARVEKIPGGEIEESRVLSGVMINKDVTHPKMRRRIDNPRVILLDCPLEYKKGESQTNIEITKEEDWNRVLQIEEEQIKAMCDKIIEFKPDLVFTEKGVSDLAQHYLLKANITALRRVRKSDNNRIARAVGATIVNRVEDLRESDIGTQCGLFHIEKMGDEYFAFLDQCQNPKACTILLRGPSKDILNEIDRNLADAMSVARNVVFNPILAPGGGATEMAISVALGEKAKLLPGVAGAPYKAIADALEVIPRTLVQNCGGNAIRTLTELRAKHAEGQHLYGVDGETGKVTDMKAYGLLESASVKIQTLKTAIESATLLLRVDDIVSARRPGEDGGAGAGVQTMGEAGPEGMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMI0</accession>
    <name>A0ABR3BMI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_105258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612362.1">
        <property type="nucleotide sequence ID" value="XM_066759715.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992114"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0243995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31099" checksum="9E2515E6A7CE0EEC" modified="2025-10-08" version="1">MSVPRLLVVGGNGFLGSAICKAAVGKGWEVSSMSSSGKPYTTPAGHTPAWVPKVSWHSASAFSPSSYSSLVSSSTAVVHTLGILLEDQGYKRAVKEGDLLSLAGGFLKGLGGGDGNPLKTAEEKRQGYEGMNRDSALEVLNTMLSTLHPSAPNETVKEKTFVYISAADAFRPLVPRRYIESKREAELEIAKRCSETDGVRPIFIRPGLMYHPHTRPLSTLPAFLIDLSSKLNAALPTPLQNIPSLFSPQSAIRGALEGARTFPLHVDHVASAVLNTAMMLPWNIKIQSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMR6</accession>
    <name>A0ABR3BMR6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612454.1">
        <property type="nucleotide sequence ID" value="XM_066759807.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992206"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="189"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0244087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="418" mass="45983" checksum="BD802B08F8237CCD" modified="2025-10-08" version="1">MAITNTNAITSDNADLDQILQTVHEEILQYAEKLKQVSMYMFENPELAFKEVKAHDCLVEFLKQEGFEVDEHFHLATSFKATFKHGEGGHTFGLNSELDALPGIGHACGHPLIAVAGVASLLGLRKAMLRYNIAGRIILLGTPAEETGGGKLKLLQANAYEGMDVCMMVHPGQSQVGQASISPTLAVQSFEVEFHGKPAHAAGAPWDGINALDAATMAYASINAMRQQLHPADRVHGIIVNGGEAPNIIPKFTSMKYFLRATTAEGMERVKEKVMPCFEAAALATGCTHSVKFNDLLTDIRNCKPIGELFSETMSTMFNIHTVQRYHDWSGGGLSTDFGNVTYAMPSCHPFYGIPCDPKRMNHTAEFEQNARADKSHEETWKVATGMAAVGLKLFRDPSFSKEAREWWEKDMRGDFMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMR7</accession>
    <name>A0ABR3BMR7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612419.1">
        <property type="nucleotide sequence ID" value="XM_066759772.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992171"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0244052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="29645" checksum="B68ED27B958ED371" modified="2025-10-08" version="1">MSNFSSTPNAPISQAQQQQVQPQHQAAPSQSQPMPFAPVSASSSVLTPVTSVVGVSAPASASISPQSALGGSTGSPAPAPISSTVNGFTTPTSTSTSVAGPSVGASGTQATITSAPNAIPVSGDQSSTSALISSSGPTRGPTGNASTSAPAATQTEAQPSSQDSFWAARREEEIARRDRSLAELLVMLDGYKPLIPEEVTEYFLQRSGFDCSDPRLKRLLSLVAQKFISDLSRDAFHFSKLRVNGATAGRGRPSAGVDRNRVVLTMDDLSLALGEHGVNLKAPDYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMY4</accession>
    <name>A0ABR3BMY4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-malate dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="4">1.1.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_104552</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:18365"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.83" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612512.1">
        <property type="nucleotide sequence ID" value="XM_066759025.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991408"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050501">
        <property type="entry name" value="ICDH/IPMDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275:SF1">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="11">
        <location>
            <begin position="24"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0245428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="374" mass="40877" checksum="D3156533776A7D12" modified="2025-10-08" version="1">MSPVRVPSHGDGWASTPETKQVYSIASIPADGIGPEVVEAAITVLKAIAKKRGTFQLDFTNFDWSSETYKKTGKYVPDNHLDILRKFDAILFGAVGAPDVPDHISLWGLRLAICQPLQQYANVRRTRILPGTESPLRNCKTGQLDWVIVRENSEGEYAGHGGRSHTGYNHEVATEISIFTRVGVERIARFAFQLAQSRPRRKLTYVTKSNAQRNGMVMWDEVVNEVAKEFPDVELDHMLVDAMTVRMVLHPESLDTIVATNLHADILSDLAAALAGSIGIAPTANLDPSRTNPSMFEPIHGSAFDITGKGIANPVATFWTAAEMLEWLGEKEAGEQLMEAVEAVCVDGIKTKDLGGSATTKEVTDAVVKRILQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN07</accession>
    <name>A0ABR3BN07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612527.1">
        <property type="nucleotide sequence ID" value="XM_066759040.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991425"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF11">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="398" mass="43157" checksum="D8EB8AD52C59BBF3" modified="2025-10-08" version="1">MSSAVRNVIVVGGSYVGSKAAQELAVVLPPTHRVLLVEPHSHFHHLFAFPRFAVVPAHEHKAFIPFASVFREPAIPNPSLHAVVRAKVNAVYPTHVSLDRAWQGETDIPYDFLAIATGTKLPAPGSMQSEDKANSVEYFKAYQEGIKAAKDIVIIGGGAVGVQMACDIKEVSPEKNVTLVQSRDHVMPKFHPKLHEIVSNRFKELGVNLVTNSRVTVPAEGFPNDGSTFSVTLKDGASIPAQLVIRATGQIPNTQLLSTLPPSSTDSLINPVNGFIRVRPTLQLQDTKYSNIFAIGDIADSGAPKAARPAMQHVGVLARNVVAMIDGKQPDQEINIEPAAIHMTMGLVQNIVFRNPDTGAGHIEPSYKFRVDGKPDMGIEDVWARRGVVVNDPSEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN32</accession>
    <name>A0ABR3BN32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612559.1">
        <property type="nucleotide sequence ID" value="XM_066759072.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991462"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0245475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="60696" checksum="D95D0EEBC8E6B91A" modified="2025-10-08" version="1">MATLAEHRAFLNSILDRQAERRRLIDPDTLHIMMKAKAREEPARIMLSTMSRRKRLSEMTIVNEGEDICSEYPALKKLMNLKAQLVSSNSHPPLYVPLSHEPLRDSLLSTFSNLRFDVIRINPSLNWAGIADLPIKQISSDPAVVFLWVGRGDQEGLERGRECFARWGFRRAEDIVWVKTNKNKNSDESAAASGALFANQKEHCLMGIKGTIKRSVDVRFAHCNVDTDIIVWEDSGDPEGPRYPPYLYTLIENFCLGTRRLEIFGRPNLARPGWVTAGLEPFSSSASTPRQNSVQLFDSQTYTSFIPESDGKPILPFSPEIDQLRPKSPVRKPQRYNNPSGGNPNNLSGGGIGNTGSRNQGGSAVNGRPSPAPRFAQNGGSSGSGTPMGNRPNLVMPNQPSPIDFSQTQGRMSPVNPMMMQGGPSMEQIMAANMGMGMGGMGGMGTGMNGPMNMMVGMPVGNQYGYGMGINGGQPGFGPPFGAGMGMPMGMGVGMGMGMPMGMDMGMGHMGNMGFDVMMPGQGHVFGHQQQQQLPQIFGNPQMGPRFGGWHGPGGQGQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN66</accession>
    <name>A0ABR3BN66_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_104637</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612589.1">
        <property type="nucleotide sequence ID" value="XM_066759102.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991493"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1198"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="1295"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="1591"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="863"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1861"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2154"/>
            <end position="2207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2297"/>
            <end position="2348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2700"/>
            <end position="2722"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1176"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="863"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="921"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2160"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="2193"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2314"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2709"/>
            <end position="2719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0245505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="2939" mass="330386" checksum="F6EAC6B7BBC589D5" modified="2025-10-08" version="1">MSKPQGKAGPSKPYGRPQKPIHKTVDLLKKNQTAAAKGKGKENGVLGNVMSLVDEVKRLPGMISVEKFVQTRAMEIHAFQTAIKTAAAQGSTRAFQSLPRHLRRRAASHNPRRVPKRLRSRAAAEIDAGDTIAKKHRKIAKLRAKGNLRDRLSRTAIFRIRQRSKRWLPTHIWHAKRYHMTNIWGWRLPVTPTLKSFRSAYRAGKRKAIAWDMSYYGVIEVEGMKEGIVKLLTGVAFGKFAGDKFENGARVAEVLVYQPESFPRGLIGPAEVLWQPLMQDKSPLNDARRIWIRIHPSMFEQVFSILKAVSGNILAEESLSKRVQALQIRDLRGELESFEIMGPKSGEVLRRVLRLCKSEKGVKFKFFNALGDPAEVPSRTIVGLNVHDPRLHFPPPQINEYEDNLSNDGVLRFNDTLPSSDLAQSELWDPTARELASEVTYTKYQLDVRRHKLGIPGTRLHPTSSDNRIPLILFQRSTHPPPSTTPQSFHGFTLLFPSSWAQYLLTSIAYTGTLIGGLNERKVQHREAGTPSFPEHFGQVCVAGEEWEKSKAEEAEERWNRKPPAKRVAFDKLGTSHPWIPDWSALMGKGVTTSEETAVNGELSIHPYLLPHPFTAHLDASLTPSKLLKNINIFRSQRGLSALPSAKQIELFREAAVHVELNVLGRGSPGDMAVICGLIEEERKAWIEAYEGESDEFGLAGEVSELQRLGEARAPEENIIGYTSTGNISLSRGKGHALGMITLAGYLDLLKAAGAEVKGNKWDGRTLVCVRNRDGRIASIRPSTLCVVFCFAGTYALSQGLDSCMEMNDMEYSPCVSTTDLIEQLLDTVYYIKKAKTTMDTYPQQHLPSSMLASDTQLDVGLAASSSVGSSQSPSSKPSSAPKITLRMPQQPEAAADFESESESLTPGPEEIGNGQGVGEEVSDQEGAGDDESEGEGEAEQDDFNYDDEEEEDYDEDEVMEEADDDDDDEDPSFGERKKKIKKARAKVESDRPVKQKKSSGAFPMRKQVDESSDEDYGTKSHKKKYFSKTGVSRRATPGTPYSDDNAFRRGAAKKVVTYNEADVDYGLESEDEAADTGYYYTAGAPAEAEPADEIDQVMFHWRDENHKDDPKDIPQTNLRFHIKWKDYSHIHNTDETYAFLKNYKGFKKVENYITKVWAIDQSYHHPAPDAAWKPTQEEMEQYEIDKERIKELQESYKIVERVLDEKEEKRKDGRVTLFFVKWTNLQYNDCTWESAKEGIEEFHQRQARTTVPARSINYSIDNRPVYQKIPENPPYLACGGALKPFQLTGLNWLAYVWSKGENGILADEMGLGKTVQSVSFLSYLFHSQHQYGPFLVVVPLSTISAWQSQFKKWAPDLNVICYMGSARSRDVIRQFEFGPLKNLKFNVLLTTYEFILKDRQDLQQIKWQVLAVDEAHRLKNHESQLYDALKSFWSASKLLITGTPLQNNVKELLALMHFLMPEKFQLANDFDLNDASEDQGAKIKDLHDKLTTLMLRRLKKDVVKELPTKSERILRVEMSAMQTHYYKNILTKNFAVLSKGGTQQVSLMNVAMELKKASNHPYLFEGAEDRNKPANEILRGLVMNSGKMVCLDMLLSRLKSDGHRVLIFSQMVRLLDIISDYMSARGYVHQRLDGTVPSDVRKKSIEHFNAPGSPDFAFLLSTRAGGLGINLETADTVIIFDSDYNPQNDLQAMARAHRIGQQRHVSIFRLVSKGTIEEDILERAMRKMLLEYAIINKMDTTGAHINGSSTPKDKNGDLSKEELSAILKFGARNMFKTDDNTQNKKLDEMNLDDILNNADAFDTESAAAPGTTSLGGEGFLSQFAAIQDVKADVDNLSWDEIIPEDERSKAEEEEKAAATAEIVAASSRKRAAAKAPGTYQDMDFDDHDGSSKPGSPNDKKPKAPGQPKKTPAQRALELKDRDLRVLIRGIQKWGDIRSRYEPIVKEAKLENKNRVVIIQTCEDIITHGEQAIAAHKAHIRDLQERGEPISSSLRQKAILFTYKGVVSINAETVVARYYELKALVEHFKRVEDFPSYTIPHDSLKPTMNWTVEWTAREDSQLLVGIWKHGFGSWEAIAHDPELQLSDKIFLEDPKAAKLDPNAPKPGVPGPVHLQRRGDYLCGIIREYEENRRILVEQQAMIASLPAKEGFGFEHPPLPSIAGPSKKPSPSIASSSKDRDAGKGKRRKTPEYTDSEDESSYESMDEDAVKELLRPAKKHLKKLKSGTENLSREEKIVALKECLAGIGARIDEVVAEKAADGQNATKWRKHCWVFASFFWPRQGVNYSKLMEIHGKMVSESAPTTSKSKAKPKRKTEDDPSKPKKKPRPSDSQKEVKVEGSSGEQPRGTYTVSRAYNVSSAQAISTFTSASYLSSKLLYILRLSIVTFPQADMARFPYVRILLRGNTPAKFLLLFFAIVFFFASPFSPRYTSIFADPPFREKAEVAPLSELANVYDQVRLGILDARRFNGSHAAEKLRAPKTLPDGTLNFDPDLEAYVRRLRSFVDNYLAGAPAHIQIAGSNTLKNLIRRLPAKHRDGEFPTKVWATHPRGMDGVESGFELWGELLPFPLPPSLANQLSRNQEVEFLKPARAGKDWGVEVLDDDGLDGAMSEWTGEKIHRGITGEGKWSQLWGKLDKGVLRADLFRYVSMLMEGGIYSDSDTMPIAHPYVWGLHAPSIINQDLKVLQDLMAVSLLPKFPPNNRPPRVEAQSGSDSDNSTYAPPYPGVRLSRRAPVYKIESPNPSSILNPSISMVVAIEWDSQIGRTLRMWKQWTWFRIARSWKDCCFPRGLQMVQNLLVSKPFHPIMMDIVATIAQLVEAGVYKELSPLELTGPGPFTDAVFRYLLVQYGITPDDLRALRGPVRVGDILILQEEAWHAPEKAIRRLKAFPLAVRARVQRLEERRSAGGVSWFDWHRELSGRIMGISICANRTIDLDRPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNL0</accession>
    <name>A0ABR3BNL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_105326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612430.1">
        <property type="nucleotide sequence ID" value="XM_066759783.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992182"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="44"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0244063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="205" mass="22659" checksum="5F2BD3814BF93A39" modified="2025-10-08" version="1">MAAIQALPTEVQKVANEGTVKLFGKWESEGVEVKDISLQDYINVNHAVYVPHTAGRYAKKQFAKGRMPIVERLVNALMMNGRNNGKKIMAVRIVQHAFEIIHLVTEQNPIQVLVDAIINTGPREDSTRIGSQGTVRRQAVDVSPLRRVNQAISLLTIGTRESAFHNSKSVSECLADELVNAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNX5</accession>
    <name>A0ABR3BNX5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein transporter SEC13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_104896</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612844.1">
        <property type="nucleotide sequence ID" value="XM_066759357.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991752"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0245760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="312" mass="33738" checksum="41E9D92A9A1758B1" modified="2025-10-08" version="1">MSAQASKPVPVETQHEDMIHDAQLDYYGKRLATCSSDRTIRIFNVIKGEAKGEPVILKGHTAAVWQVSWAHPSFGSILASCSYDGRVFIWKEVGQGQGKGSVNSIAWAPYDLGPILACASSDGKVSVLSFQNDGSIEASIFPAHGTGANAISWAPSVLSTASGVSRSQQPSNSLTPQRRFVTAGSDNLIRIWGFDEEQKKWTEEETIKGHEDWVRDVAWAPNIGLPGMYIASASQDRTVLIHSRPSPSSPWTSTPLLPSLPQSQDPHFPDAVWRVSWSLAGNVLAVSCGDGKVSLWKEGVGKGWECVSDFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP43</accession>
    <name>A0ABR3BP43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vesicle-fusing ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104581</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612538.1">
        <property type="nucleotide sequence ID" value="XM_066759051.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991437"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="10">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="165"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0245454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="48467" checksum="BA67EC14BF419ECE" modified="2025-10-08" version="1">MSNSNFLDKAIALVQKAIDEDVKQNYAEAYKQYQDALDYFMMAMKYEKNDKLKELIRKKFTEYLDRAEKLKEHIAKSEEKRSKAKVSAAGASAGSTAGGPDVKGDDGDDPEIKKMRQGLQGAILSESPNVKWEDVAGLAQAKEALKEAVILPIKFPQLFTGKRTPWRGILLYGPPGTGKSYLAKAVATEAKSTFFSVSSSDLVSKWMGESERLVKQLFQMAREQKPAIIFIDEIDSLTGARGEGESEASRRIKTEFLVQMNGVGNEETGVLVLGATNIPWQLDPAIKRRFEKRIYIPLPDIQARRRMFEINIGSTPHGLTPADFTHLAEQTDGYSGSDIAVIVRDALMQPVRKVLSATHFKEVEADTPEGPQIKLTPCSPGAPGAVEKTWTDIESSELLEPLLGLKDFEKAITVNRPTVSTKDIEKHIQFTNESGGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPJ1</accession>
    <name>A0ABR3BPJ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612519.1">
        <property type="nucleotide sequence ID" value="XM_066759032.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991416"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1039" mass="115827" checksum="7ED04D807DB428FF" modified="2025-10-08" version="1">MNRRTPTPSSHLTSSPALSYIWSDTSGENGMRPRKGNEAPSTSTSVWSDEGTAVPRHGNGVKEGKLIDYDDEPQPHQREMAPGDKLRDLLRQMDEEVRRTAPRQPREAAVPYQWTGYTRPRQFQPDTRDEETEDEEKPDGGLEEEREETSSARSSFVSEHEGPPTPPPRFGNPYSRRSERRGSPAFAQGRLPSRAAVLLQSTSHSDEGSQTVKEPEPVANYQKSPRSQLHAYIASHPEPGSSSSSRAHQHVSQSPSSMSGRKGREIEQDREFEHEPSPPSPHQFERELSNSASRRHYRTDYSPSHASPPLDVLPSSGSPHRSPVLPRTLEPKRQRRSQPAPPTPRRLSIDPLPSTHDEFAMHLKGLEVRAEVELDLDEGVSAVGWEESTVEGDEEEVRYEDGVDMDGDRDRSGTARPGWSRRESPYTHSQSRERLYQSALRSHPSPLSRRLPSRSPSPPALPDLPSHSVSGSEEEEEVDTYSSRRARMFSGKRKGKVPMVDGEGEASASASSSKSYSRSLPGRLDEGKDKESTRECRKEDEEMKNDVPEEEFLEEGLEGERVTMEEREQSNYHSPDQHSRTPLSTNHHHTPSPVRLPLHQNRTRTSLTASQTGTITGSTTPSPRQRQPHSLSSSRSLLQSQSQAQTPKLPPSFSSSSSNANPSQKQLTTPSQSHSQTIALGPTPRPPGAWNVTPFPRRLRREHESPRHRDQVPSGDRAGRVRFSPLRYETTIHREDYERDDEKGEKGRKEEEGGDVSILTLSLSPRRKSAKSTKSPKSPKSRMSPEGRAKEERMEEDVGDISWTAKLARSVTSRIPIPMRSTTYNAHLPQLTSAHTHTQMVSSKLQGAQQSWLAALSSVSTSSDPYLHQHNHQTSSNFPASLALRTSQNLGKGMNKAIRWSRWVWWVLVEVILLWAVFRVTLDYAGSGIYLGRDPFHPLSRPLGLGPPPSLSSPPSLSARGMADTMEGGRETERMTDAQRQWAKAPRYVNLEIPIPGGLRTLVGKQGSANFFDLVESWGWGTAFFGEGEPAGGWIGVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ36</accession>
    <name>A0ABR3BQ36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104185</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613111.1">
        <property type="nucleotide sequence ID" value="XM_066758663.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991041"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1201"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1523"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1632"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1161"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1295"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1487"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1171"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1318"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1373"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1419"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1453"/>
            <end position="1462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0247150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1724" mass="191533" checksum="D19C24380282FFED" modified="2025-10-08" version="1">MADEQLAAWFTLTHQRNVLHLDFSGVITASAFLTIQPTNPSLQAIYLHASPHLHIHSIFLSSPTPKEPLLSNPASFALSNPYQPLPVREPPIDIKSHPEIKRKTWAAMGESDEGELAISVSGGWVRLVESQNIAGQDAQVTFAPIQVQIDYQLVVGGDVVEGIVFRRPGDGGNEYQIPHMFLSPTTYNSARVWTPCIDSLFERCTWELEFIVPRYLEGGEPVDGEEGYPVMVVSSGELMEQITHPHDPHKVIFYYLQTNPTSVQHISFAAGPFQMHCISADDTHKPILGFCLPGDLDLLANSTSFLPRVMAFTTELGSYPYTDFKVVFVNNPRSECSTSATLAIASSDLLHPPSVIEQAISVRQTLSLALIQQWIGINIIQRNYSDTWIVNGLALYILGQFIRHLLGNNEYRFRLKKDIDRCVMQDQGSQWPLCVPGQVDPPDSATTAFINIKAPLVLHILDRHLAKAGTSLGLSQVIPRILMAALSDDLPGNTLTTSYFLRQCRKVSGLDLQTFQDQWIFGSGCPRMSIRTNFIKKKFTVEFMVSQTQPAAEAINEMSEKQRKVAVWRRPTPFFEGSLTVRIHEADGAPFEHLIDIKTPQKTFPLPFNTKYKRTRRSGHIAARFNKMQDALDAANEPSNDDEEEAKLEAADRAGVFAYPPWDDEEERRRWKVAEWGEGEANAMLGEGGGYEWIRVDPDCEWLAVFEFIEKPWCWISQLQGDRDVIAQLEAIQNMRMYPSPVIASELARTILVKNYFYRVRMEAARALAMYNNSECDYIGYFLIMKIFQVFYCQPSSGNETEPTEIRCFPLPNDFSNFADYFVKKSLIAAMADLRDPATRAVWKHVRITLLDLLRLNDNTSNQYSDSFYLAAIITAISNAFTVGSAAQGMLSETEIESEQLLQKEANDVLDRAMTVDRLVPSYHNVVTKAGLEAQMKSILAGQRTNDSREFLSYTREGNFEAVRMVAFDGLLLCKPPGRSPAVDKYLLDVITNDQSLTIRRFVARNLSESILVSLALGEITGALPLPGVVDVTNETDQMREQRAEGQNNAIVKALRKDFGAKLEVKRLVQDNLIESFTMPDPEVRFALLKVAEIISSSTSEPLPGNLITLSTPTVETPAAPQPPKIRISVSSAEIVPDSQDYGFPTSENPVVTPRTAAKIVLNPNAPTPSTHKKKDAPKAQRKGLSDNDFKAIVIALNKLVTDKRSFFFRQPVDPVRDMAPDYLTVIKKPMDLSTIRAKLDNGMYTSRQEFVSDIRLIITNCYTYNSTPASPVRKAGEAFEKLFNTLWAKTENTLSAQRSSHATTPSKAMPPPPLPQAEPTASTSVKVKVKPPKSVAIDAAPGPVMPPPPLPIAKKLPAAEEKKEKQVKKRKEPGEVGKSDLDDLLGAEVDAMGSKVTSSDPLADLLEEPKQPAKKSKLPLSSKPSKSTTPKEFSAASSSSNEKPSVKKAKIKVPSGSSSSPVPKPPVPTEEPSVSQALILPPIAPSATISAQPQPPSDLPPTKSNSMSFKTKRAKALLTTLQKEPSAILFLRPVDPILDGCPTYLEEIKHPMDLGTIGKKIEQKKYKTMGQFARDIELVFANCRQFNPPGEITALADRVEEVYWKDWPKTVSSKMTGDERKSMVSMLNQALKNPLSEWFRLAVDPVALGIPQYFDIIPPEDARDLGLIKSKLEKGQYQTAKQVDEEVELMLENARVFNGEGPVVDAANALGKWWQAQRSKMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ57</accession>
    <name>A0ABR3BQ57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vacuolar assembly and vacuolar traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612744.1">
        <property type="nucleotide sequence ID" value="XM_066759257.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991650"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016902">
        <property type="entry name" value="Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
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    </dbReference>
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        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="7">
        <location>
            <begin position="143"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="5">
        <location>
            <begin position="723"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
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            <begin position="57"/>
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        </location>
    </feature>
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        <location>
            <begin position="90"/>
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            <begin position="120"/>
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            <begin position="693"/>
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            <dbReference type="ARBA" id="ARBA00009582"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
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        <source>
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        </source>
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    </evidence>
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            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1046" mass="117379" checksum="B901A6843712A0AC" modified="2025-10-08" version="1">MLSSNHSSASSPSKPASVHDTTEAGPSVQSQRPRISSLSSASSSASRKGKDRAAVPDGDDGDSELSGTESEEEDSEEEDDDDEEEEEKEEDQRSERSGHESENKDKSSINENPSEHGDEQVEDEEEEEDSEESSDEEEEEPALKYSRLKGRIPEILTKDTAATISVSPRSVALGTHNGMVHILTYEGVKTNSFRPHAASVTCLRMDESDDFVATSSVEGRVVIHSLSTPESYAFDYKRPMRAVALEPDFAKKKSRAFVCGGMAGNLILQEKGWMGYKEQILHSGEGPIWAIEWRRNLIAWANDLGVKIYDTNTGQRIGYIDRGASAPRAELFKCTLQWKDDQTLLIGWADHIKVVRVRSRPSSQASGNLPPLTVEMTAIYQVDCMVSGIAPFGGSYVILAYVAPDRYENEATDDPIEQRRKAANRPELRIIDKGEETNADALSLANYHMYGCNDYSLVKSQKPGEEAFLVISPADVIVVRPRDEADHIEWLVERERFQEALEAAEEMQKKHGSAFDIKGIGLKYMRHLVSKEQFEPAAELAPKILEQDATAWEKWIDIFVQHQQLPAIIPYIPTQKPRLGRRVYEMVFTHLLINDKQALPKVITSWPTEIYDLTTLVEAIQGELQASHDDPILLECLGELYLINRLPAKALPYFLRIRKPYVFELIREHNLFTAIRDQALQLITFDQERKKARSKVENQRGEKTDDTEIESVEGDKSKHGAAIQLLVDHVHSIPIDRVVHQLETKPQYLYMYLDALLDKDPQYSLPYGDRMVELYAAYDVDRLMPFLRTSNFYDLEKAYAVCKERDYVPEMVFLLGRMGNNKQALMLLIERLGDVERAIEFAKEQADEDLWEDLLAYSESRPDFIRALLEHVGAEINPIRLIGRIRNGMEIPGLKPALVKILQASNLQVSLLEGCQHILNGDCAGLMGQLQKGQTNGLKASSTSTCAVCSKPAFTNQASLVLIYLCQHLVHAECVLPEGIDLPVRQENASVAYLLADEGRMGRHGGAAWKTRNLGTRLGYAAAVRVRVRQCPVCEQAGTLDKRHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ81</accession>
    <name>A0ABR3BQ81_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066758861.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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            <end position="117"/>
        </location>
    </feature>
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        <location>
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            <end position="178"/>
        </location>
    </feature>
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        </location>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQJ3</accession>
    <name>A0ABR3BQJ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066758630.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991008"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="828" mass="84109" checksum="18C829F3D5137891" modified="2025-10-08" version="1">MASSFLLHHLFPGIGGATMDNKVRLIGPLWGLTSLLFVTPLALAQSSGIIKFSSTSACIIVAQIASLSSPSTISAMMPICPDSDDTAIAWPLTTNGDGASSSIAIYAHTTATDGGVSVGCVMGLSQMQAMYLLGRDLTWNDSAGTLYDNTAGGNLLDPTTYATITCGSSDTLLPSGLVLPDPSSNAAGASVWDQTITLNAGAKVTGGSDNTITTSTIVKVSSAAAPASSSIPMTPAAATTSANLVTSAQPVTSPVRMTSAAADELPTSSESLYTSDPIPNYQASSSHLQDFTTTSAQSSDSASFSATDENDYSFVNGDYDSTSVIAVQTNSNLKASSSVVPSDNQHVTSFDASTYPPSTTSTLSSVYHTDDTYEGNSDSNLSDPEVASRTSPSGSSSGPTSVPAAIASNTYPIPSHRSNGGITITALDARPSSTTQESSSQSDSSEAGSLSSSVSETSPTRNDDNDSPSETDQSQSQYFEPSSSIVSFEQFPTPTFSHQPTTYALFHVPAPSSSASSDEPFVFTIGGITIGQFTEAGVGAVLAAQINAISTTGQGTHATAVAESSVWAEATAAEDIEGSARASASVSAVIVTLAAPTGSSLVDANDGSSVTLANGSVSAGAPTTSGGARETSDGNRSGEDNFDSYTSASASTRAGEAKATGGSEGDVSTSAAFVDVSSTEAGNRMNLTRVLAAFVSGTQASRGTAKGKHKNYNKESGVGENTAGVTSDSTITAPTESSSLRTLSGSLVAEPTSMSPRVQAFSNNRNSSASFWDVIVSASSFVDGASYSLESGSPQKTVVAVGQSSGKTCSRKRKEKARRARALLMEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQV4</accession>
    <name>A0ABR3BQV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612999.1">
        <property type="nucleotide sequence ID" value="XM_066758551.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990927"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="663" mass="74994" checksum="4E3F514C1F618CC2" modified="2025-10-08" version="1">MASMLERLLAKTLPKQTPPTDDQPDSTPYRPRREPLPYEIPDPKGTPWLLKLPDEVLERVFSNVDRVTFVRCHRVCSQINNFLSGNASMKLRNLLQTSSLILNPNALLPDAVNTHLVPPSKAQLLDTLRERLTRFRTFSPKSEETIKFQEYEGRLYEFLEGVLVRSVPIPYTRQIGNEIGVYEFGKMGEWEDVKNKPGDGKDGGGKDGDEDDAMGEIIDIEEGEEFGNIRRTHKFGFQMLDFAFDPGQDLFVVAEYKPHPQDPTINLHLFTLSTFQPHPRAKEHILTWPSGTLYGRAPSLGFQICDDGLFVLKNHHRGSKDMLCGWQWTTGRLAVTLIAPHTSTFESFICLTPSSLAIPSVSTTLNPDSEILGDLTDPSDLIFSHHLNIYAFPPLSSMTVNEHEPVPPPHTATHVTTIDLPEFVIDFENNLPPPRMTIRADPAPRYNLPIHPIGSPQPFIPDPESGIVVLEFYCQPTEDEEGHLQTTHYVMFVRKKTLLGYLPAPTSPLLFSAFPRPAPVVPFANIAAKVRMLGPHQYVPSWVCYVYQDRYVTRSDVESEPCIQLYDFDPMRVRQAQFDPELKDGGNSFELITEEADVPSHQEYRHSTLVHSVRTGAELPCTVAELELPDDGVHTIIIDAERIIAFDDSEDENDELFMRVMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQW9</accession>
    <name>A0ABR3BQW9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613552.1">
        <property type="nucleotide sequence ID" value="XM_066758150.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990521"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0247591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="642" mass="71218" checksum="F03AFAEC70E7652A" modified="2025-10-08" version="1">MPLEPLADSIPPKKRARAEKTTIRSNISIACQSCRLKRAKCDGKTPCAKCQQHNLTCMYENDGRRGNSLHKQLKTLSDENELLRSILENYGISRDEAAAGVEQRPIRSIPVSSVQRSLDPISASNGFYKDNRSGQVIHHGSSTFHSILGEQDATSPHAPASSSHAYDNFPYQLQNIAPDVIGFHNLPSDIHEELLDLFFTYINGYCVNIDREAFMEGMNSGGPSASYSRLLHLAILTEASHLSLHPQLRSDPDDMRTAGIAFQSEAMALLQLEMEPKVTTALALCMFCTTISDCGQIFQSWLMAGNAVRIAQHVGLHLENPTVIGEEDKEARRKGMWGIFFQDKLMSLFMGRACALQYEDLNLPLPDYSASPAMWDSTAYLEQNTFTGMSRLAVICGHIMKDIYGARSEHHLTSRRAIQSLDDALITWAKELPPPIQDAPGGIRSQTPYVLRLHITHQNLILLLHRPFLRQSSGTDGIGRERCFKSATRMAELLYLYNALHGLQRTSLSIAHGAYTAAITLLLLHLDETNPRNMAALTQTFTKIISSLLTIGLSWSTPNRAVVAINFFANKCLGNRTRYEDKELLNVILDAAKKVQPERVESSLGESMGQPTGSTGLAFDLDAYLNGDLFLSHVLDIDFTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR38</accession>
    <name>A0ABR3BR38_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin lateral binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613612.1">
        <property type="nucleotide sequence ID" value="XM_066758210.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990584"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18798" checksum="F700D71BE1DC2FFA" modified="2025-10-08" version="1">MDKIKERFAILGQKIEAAEARAEAAESENKKLNQTLLERDQELASVQHKLQLAEEELEASESKVKELKAASDEGETHRTTGENLARKVQLLEEELDKAEKDLKETTEKLRQVDVKAEHFERQVQRLEQERDEWERKHGEAVEKYQQSKRELDEVVMQMESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR80</accession>
    <name>A0ABR3BR80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066758254.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990629"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="362"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="662"/>
        </location>
    </feature>
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        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="720"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="983"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAL0247695.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1149" mass="121233" checksum="0967621F52BBA960" modified="2025-10-08" version="1">MSMHFAPQWAKPIKPSGSTTTTPTTEVPLRKSTTSSPFPALSANPPSASPTTATHPTLSYSRVTHTPSSPNVATEGYFPNQDLNGGEVNAHPFRYSREQILGLFDESKFKERPIELVEMAEGGGVLVSLSLNRPIGTRDLTDAEKKILSTSVHPALSTRRQLNQTNTTGEHATNGLPARRNAGFTRGEGGAFSGSLGKMGSFGGGVLSPGGIDHKAPGALGGGFGGVAKRMSRRNEDSGGESRSSAATWRSGPKTPVGNFEGVLGFGNSAAPLSPSGETSEQKEVGQRKWRIAAGLPTGESDKTLDVPISNQAGVSASVIATPSATPIPDRDATVLDLTPAPAPTSQTPQAPIQEPKEDLGAVEWFYRDPNGQEQGPFTGTQMHDWYSHSYFTDDLPLRRASESGFSPLSELKAATGNAVQPFLSPIRPRQLPPNLPIPIAALQQHAMNNLPENFRNLSVQSPIGSDPRISPQPPVPSVPGAAPYIPGYDAAFSHNYPLGHQSLDQVASPGYAPSPTQGWNALAPQPSLRVGMSPLTPAPFSNISVPSPIGSAPLQYMQQQQQQPQQPQQHPGYFGGPQQMTMKSAPGDIYGQPQPWGVQGLQQQAGGFPQQMGYQPQTQSQPQPQSVPVQWDQPQIPQQVLPEQIQQQQQQQQEIEQPLPVSESMNEGSRPEQVEETVEIKVSPEPEADLLPEIAESVKEQVAIDLDQEEEDEVEELTPVESPVTSTLPSKPAPAPTTSAWKKTQTPGREDSLTDSVDPTPAQAASVKPSKPTSKEESIEIIPTPVQLPKVVDVSTPGPTADASASPSLERSSSKPKIAPWAIKNEERVAPSPSLRDIQEAEAKRAEARRVALAEARAATASPALVSASSEDLPTSMSWGLPSQTGKGIVRSHSPAAPSTPGPAVAAWGGAGETPKKTLKQIQEEEEKRKARAAQAARVAQGQAAGVGASAVSTVGSTRRGYADLAAAPVKREEAPPGWTTVGASGRAASSSGVPRAATPIKPTPAPVVKPAATPVPVKKATGPSASTVDDGAPSVEFIRWTKQALTGFKGDVDDFISVLLSFPIDPPAASRADQMEIISDSVYANSSTLDGRRFAQEFMAKRKADAARPGGAAGKKISSLADVVKTQPKQTSDAGFKVVKAKGKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRF9</accession>
    <name>A0ABR3BRF9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GLTSCR protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066758328.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990703"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015671">
        <property type="entry name" value="GSCR1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15249">
        <property type="entry name" value="GLTSCR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLTSCR protein conserved" evidence="3">
        <location>
            <begin position="137"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="508" mass="52442" checksum="12D9F58C61EC50C6" modified="2025-10-08" version="1">MEIDPKPTQSSSGEGIINGGGNITSGQGVGGQRKDVTGGGAPSGAVTGMDISRTSTPGAGPSTTPLPSKAGTPGATPQTPVTAPEEDQATAGSSAGPSWEVQLAGRKRKWSILGFTKEEQDVMEHDSLSLQLALAMDQEATLYPPSPTAFTSYEDAVQRLLPYHVWQVYDEELDTWEKADVAKETKEAEGILDKIKGLKERFAKARRREDDHLSPLPSTISFFQSSTSNIREDLTSLQTNLRTARAELSAIEQEQKKIAEERRKEKMEEEGRKAVAAMAMQQAARQQLMGQAQAQKSNQALSRAATPGAQLPGFSPVSTPSRTGSPPKRGRGRPPAALGKISGPPSGSFSARSEAPGTLTPSGVSAPVAPGTPQSSAAVGGIGAGRPPGQMVNGSGTSTPVRPPNPPPQGPVSITVNLSLIPQLVAIGLIAVPPNTAPGAPKPPGIIIKSLDDKKSVVIQINLAMCSKPQLLGLAKVLNVNTVKSATPSAPSTPGGSGSGSGAGPSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRK9</accession>
    <name>A0ABR3BRK9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613791.1">
        <property type="nucleotide sequence ID" value="XM_066758389.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990764"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="89" mass="9632" checksum="6DB2220620CFDD28" modified="2025-10-08" version="1">MSSSTVKQRHYSALASRIRTLHANLAETEGLLEMMTHQLDATSKMGVHCGSQFMAVSRLLDKELKDLMDAATASEPQSPSAAPSPERSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRQ8</accession>
    <name>A0ABR3BRQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613838.1">
        <property type="nucleotide sequence ID" value="XM_066758436.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990811"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="263" mass="28593" checksum="B139A834C37D724F" modified="2025-10-08" version="1">MRLTHDFVSNAPSHLNPLKERELELRGLQIPVIENLASHQGTYDTLNLNENSITVLGNIPNSPRLQAIHAANNQISSISPSLPPNIPNLVTLILTDNAISSLASLIPLETLTSLRHLSLRGNPVTQQEHYKEFVVWKVAKGNLHTLDFERIKDSVRESARKLLTDPLTSLPNSLAHQLSIPTTSNVPGSTLSTKTLLSSDAQKGPGAKGRLMTPDEKRRVVEALTRAQTADEVRKLERMLADGLVPEGGVDEAVEGAVEVNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS64</accession>
    <name>A0ABR3BS64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arf/Sar family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613988.1">
        <property type="nucleotide sequence ID" value="XM_066757604.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989959"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046655809" description="Arf/Sar family protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0249801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19969" checksum="708A23FF638489DA" modified="2025-10-08" version="1">MASIFSGLFNWLLSLFFAKHLEVTIVGLQASGKTSLVNVLGSDQWSEDVVPTVAFNLRQVRKGNVTMKIWDVAGQPKFRGMWDRYCRGADAIIYVVDAADHQSIPTATSELHALLHIPALASVPLLVLANKNDLPGAMGVDELIKEMRLGEIGGRAVSCYSTSNKTKHNLDIVLAWLTQRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS66</accession>
    <name>A0ABR3BS66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ketosynthase family 3 (KS3) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_103085</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613970.1">
        <property type="nucleotide sequence ID" value="XM_066757586.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989941"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="675"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0249783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1438" mass="157533" checksum="3CEDB32C5B288A0B" modified="2025-10-08" version="1">MAAEGMDKESIVRRELTSRCIAIMNRADPALLEYMKYHIDNADPSKGPTFKKIKEFGQILLDNCKEVVDKPPVYRDVALPTAPHTEVSAKGDIIYSEVSRQNVRKLESYVKEMASGGEVEPAVNLEKVQSDIEKLWELVNSQPSITAAQKSAIKSMYSEVIKSLGQSSGSAVEDAESPAIARTKGTKQRRSSSQFLRPNVEDRTEVEETHLPFLHLKRKTGTSFSYSAKLTNIYFDVLTEIATSGVTFAKKAALLTGVGKGSIGVEILKGLLSGGCTCIVTTSRYSRAAVDYYKNIFHELGSKGSKLVVVPFNGASRQDVEALVDYIYSTLQIDLDYIIPFAALPENGREIDSIDDKSELAHRLMLTNLLRLLGAVKQKKAARQFVTRPTQVVLPLSPNHGIFGNDGLYSESKISLETLFNRWSAESWGEYLCIAGAVIGWTRGTGLMSATNFVAEGLEKLGVRTFSPKEMAFNILGLMHPLLFDITQIEPIWADLNGGMDRVAGLAEVMTSIRVDINRMAELRKAITLDNSADFRVINGGDAERLHQKVAIAPRANFSFDFPKIDGDDILNELKHLQGLIDLDKVIVCTGFAEVGPWGSSRTRWEMEARGEFTIEGCIEMAWMMGFIKHLDGKLGNGQTYVGWVDAKSGEPVDDKDVKTKYEKEIIKHAGIRLIEPDLFWGYNPEKKGFIQEIELNHDLEPLEVAAEEAARFKREHGDKVDVWAQESGEWFVKFNKGARIFLPKAVKFDRVVAGQLPTGWDARRFGLPDDIIAQTDRTALWALVCTMEALIMSGVTDPYELYKYIHPSEVGTSLGSGMGGMHSMSAMFKDRREERDVQKDILQETFINTVAGWVNLLLLSSSGPVKIPVGACATALQSVEIACDTIISGKAKVMIAGGFDDFSEEGSFEFANMKATSNAETEFAMGREPNEFSRPMTSTRAGFMESQGCGVHVMMSAKTAIEMGASIQGIVAYSSTHTDKAGRSIPAPGRGILSTAREITPKEALPLLDVKYRSRQLAFRRKQISQWLENEHELLRMELETRKGGDNEEWFQNRVAFIDDEAKRQEKEALATFGMLEGSHPNVAPLRRALAVWGLDADSVGAISCHGTSTKANDKNESGVYNLQFEQLGRTPGNAVPVIAQKSLTGHPKGGAAAWMFNGMCQTINSALVPGNHNADNISEELRAFPHLFYPSKPIQHVRLECGLLTSFGFGQVGGQIAIVHPRYLFAALQAHELEAYKKRRQDRELDTYSRMSSALVNNNMVQIKDGPPYTAELEGGVLLNPLARAGPSKNSFAFQGKLPTKVPVDIKNAETLKAMFDQAGALSGVGVDTELISSVPTSETFRERNFTADEISYCNSAADPVASFAGRWAAKEAVFKALSVPSKGAGAPLKEIEIVSTPSGPTVKLSGDALAAAGGKSVKVSLSHSDTSVVAFAVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSA2</accession>
    <name>A0ABR3BSA2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_103635</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613524.1">
        <property type="nucleotide sequence ID" value="XM_066758122.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990491"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="838"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="884"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="934"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="997"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1037"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1196"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1236"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1282"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1327"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1381"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1415"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="281"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="360"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="454"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1465"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0247563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1506" mass="167011" checksum="ED5BEDA78F27B9DB" modified="2025-10-08" version="1">MAEDINIFADEEGDVCRVCRLGEEPDNPLVYPCKCSGSVRFVHPDCLKQWVAQSQKKHCEICGHKYTFTKVYPKELPTVIPTAVYLRQGLLFLRRRVLWVLRAWLVVIVWLVILPAWNIGALFFMSLLSDLIGLKASPSEKAIDSATNATIVESTLAANTTAVTQNFVSIPSFIASPFLYANDVVRSSFQKWLQGEENTAVGFVLRGQILSLSMAAVLIGLVLLREWVHQHNWQEAEQPPRHIEPEPNPDEWFILHGVARRQVDVIARVLEATQNRAPLSLRTARRNFPPADVPTEATGGEAESGDDNDTVNDVSERLLIGGGQELNEEWWERQRSWANGLPAEHRGTFHEILTSLQATADAAQKAESEGQNQDVPSAQISTNNPLFQEPGIPPRIWVEAPQEKQEQAEISNDRSDGEESGGASSEAIELGDPMAFDPLAEYRRFHALREQQQAAVTLDSADDNDGEIRGRAGPSRPAWSRTATAVGDEEREERDRVAYSAPELLKEDEVEGKGKAPASDEDVEHKEEETSFERTGGPWKPLFDPSESDDDTLQRKTEEEHGGEGDNDGDGEWEDEPDARPNPFNFDFGNLQVPVANEAALAPLRDQQNINGLENFNLAAFNDRPPAFANMPEEGIRLVRPEELGFPAAEDGANVEFVEEEEDQWDPDDWNGVLEVVGLVGPIHGLFQNLIFALFIMGFGVILILGVPMLIGKLFLSFDFFRTALGVSSKILIIIRKVTDPVVDIVLEIVKDVVVLPLMASGRAAEKIVAKKLGLEVGYRLGSSSGGFSRITAGESASRFSPIVEKAIDYIATFGQFCYDSYNSILAFEHRIATSTSFSGRAACVATGYAFVAGLITLIAIAGRARLTRTATEFTETLNQHSNFVKVAFFMTLELVAFPLCVGGMIDLCFVPLFPGATILSRWENLLRSPFGTAFIDWLVGSMFMFSFSTLLGQVRKVTRPGTMFFVRDPGDPNFSPVKDIVDKTTLHQLRKLGSSAIMYSAVVFSLFGVASWGLAYVPGGFLPLKMEPTFGPITSIPFDLLFLHLAIPPTIDLICPQTRARRLFTQWWRAVTTRYRLTNLVAPVPNENERSETPTKLENALWPICDWICQKLFGKYRIEATDARVPASDSVILMPIEQRRKEGGVFVPLDGSGIPYNRADKLRLLKQDKIAREAGRLPTSDYTIVWLPKYWRTRIHMFVATALASMSIVIALAAFTPLAVGRMMWKALGMDVHDGYSWFAGAYILYFSLTLGRRARKYITSLNRAERLRASIFSKRVKRGLLRWIAGTYGVITFYLVVPALVGMVIDVYLGGLWSNRINMGRVIHVWDAWALGTAFCSIVVGVVGLLPRARRTGFHNICERFREPAAKNFKSTTRLARPVLVPSVILLVVPHVVGTALVELLPESAIQEENNAILFRSAILPVILVLSVTYATSRYLEAEASTIRQKVIEAEYVVEERVENYVPPASNGAQSGKLESAGAGPGSIGDNTEKAAINNEGDDDWEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSC1</accession>
    <name>A0ABR3BSC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_103164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614048.1">
        <property type="nucleotide sequence ID" value="XM_066757664.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990020"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="610"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="777"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="841"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="886"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0249861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="957" mass="106356" checksum="2C7A04FC0A96474F" modified="2025-10-08" version="1">MKFGTLLELNSNIEWWDYYVDYDALKKLFPSTPLDPSYRATHRNNESSAILPFRRASNKYASPEEFKQALDKERNKVTEFYKSKFEELTRSFEQLEEEIAGLEERDLHDDTIKEVDEEEEDAEEGQGERQDIPSTRETDNLLGHSSSPTRARSPNRARSPLPRPRPSFVGRLGSSFNFGRRKSAALPNPRDPDILEASIQPTYRSSQSANATRPRMSDSMTSSYFDEHAPGRVPGPRSGRRVSDFDSSADDIRTTPGGHDRRASMSSLSSHEGDFNWHRRRYNSLGLVEMDPSTVPDWAVTSVGDVEEGRNGFLHGPNAKQAVFVWTANNDYATVLRIGLKKRISKVWLDAYALKQYVELNMTAFEKILKKYDKNTDSKLKKQYISEVVLQSVPWTETSKKDIEEFLTRILFLYRRVVAGGDDDIAREQLRSQLREKVVVDRETVWSQMVSGRNRSEGIFRSVTPDQIASTEPNKNVLKTPCGSFRVPTWLTMKAAMVILATVCSILIVHLQPLDRVEESNCMAMLVFCIILWATEAIPLFVTSLAVPFLTVTLRVLRSSDGEDERLSAADATKYIFSQMFSPTIMLLIGGFTIAAVLSKTRLDVMTATRILNAAGSNPSVVLLVLMSVATFASMWISNVAAPTLCYALIKPITDELHPKSNFSKCLIIAIALAANIGGQASPISSPQNLISLGAMDPPLSWLQWFAISIPVSALSVLLIWAFLHINYRWESDLEIPKMRKNTDSLTVTHYYVLSVSALTILLWCAEKSLEDWVGDMGIIAIVPLLAFFGTGILSKEDFHSFHWSIVFLAMGGVALGKATLSSGLLDMLNSLLEGLVEGMGLYSILIVFSVLALVIATFISHTIAAVLLVPIATRIGDSLDEPHPRLLIMATALICSAGMGLPVSGFPNMTAITQENKLGQRFIGASDFLKNGILSSILAMFVIVTVGYAIMRTLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSD3</accession>
    <name>A0ABR3BSD3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613861.1">
        <property type="nucleotide sequence ID" value="XM_066758459.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990834"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1516" mass="165125" checksum="0B5AEB2485C03D29" modified="2025-10-08" version="1">MAKSLTLFSPYSILTYDPPSSPISYVGLYRQRELGASESQSPQTIPRESKSSGDNPDKTPSARAKVLPWVQGVQMSEGSIPDSLFGPYPSRPQSKAEPQSQFGHPYATMASLPFGAGHRLGEDPAAVLELMKNQRPGSGAFSRGAGEEAGMKKSYIFGKAGADTPGGLSETSPGMGTFGLESKDVASKVPTTLNPVRFPKSTRQDAPQSKPDSDEEIQYRIHKPHHEFPFSHSKAEAKQREGIEDARAAALAQLETAQHNVDADLKRGMMEILGMMSSAGLSEIGAASAQDGNGLKGPRQTFDTSTRGPSFGHILHQNDVPISARPSMHVGPESFGPGHSLTGVSEVFRIPFGVPIGMSIPGPLMVMRDSAETPGGLGFGMPTLLDIIEGHGGGSPFGRRPEDRSAYVETVEDEGEDLSPIHTEVGTEVQSKAPFRADVAAAGFRSTAQSFPQDDVFPAKTESNVLGDPGTAKSNTRGTGYTEQADTLSHPTRPSTEYLMASTVRPLKASTHRAHPPTAAPFKVDSKTPDAKSKARSEAGSKAHIKAANKAPTASEAPTAGMPSMGSQVTNVQPPPAAYTKSQKGPTAMPHAHAYPQSQVPGHIPLPRQSHYEHPIVSEVADPEYRVQPRPQLDQKAVYSQVQTKNAPTIIPGQLPIQEHVPSTESIDDAVRRHHEFEEVQGATGERESVTPSHHGSVAPTTMSNVKRLVEASRYHDETLCQLLDAARLNLIGEEAKKALQRAARARVIELRELREAGEIEVGSLDPTVVLPSHAERSPKKRERRKSKEKGRTVSGKSAKSAKSEKSAMKQGPPPWVQDIMKRLSTFDQRFTALEIQKNIQGSQVSQMSRDTPNELIDELTFNHLPSTGFTNGNIMSHLLTNSDLFGQSMSPMCAARAAEHVSSAVEQTQRVESGMPSLYSHKPLSHHVIGGASSAQDAETQAPTQVSATQCAPIQPFATQYSQQAGATSQARTVAPFTESAQGDLIWGSDVELPQPKEIISFPHIRGPIINILPPTESNMGKNKASTRASPQSRTVSASRSHPPPVAGGKMVPDEDRIDVIAEQSLGSVAVPDPREKKLPPQPSESVKIQPSHSGLFGTNGAAQRIRPEIVIGSTMSKSMAQSAYSYGPPDQYPPPAPRLRTANTQVPSTADIGANADIVPGPMYGTTVEPPTASFFPEQTMYHTAVPGTTAAPAPAFTMHPAPVPSTSRDLNEPRSTVHMRLHETISCPLTATAPGKSVSPPRDRIRVVDSLYPPMAGWKPWNMLTQRLYSWALIMKEKSFVKALEDISLGRQVEAFPLSVFLMLAYKRWVRRNSSVTPAAPCDKLFVPPNMAIAINIAVHNRRYHEAKEILLELWDCLGLKESPRIIVALAPLGNETDQWAAHRYDLTSKHLTTYRVSHLAEIQTDGRSFWWWEAIRQAWPELQVPEMQDLEKRSGQRIINEHRPPEYKRDNSLYAANISRNLLVGRGYRPERQHDLVKQRQIIWTEVKRLLHKKRTGRLVVEPDSPEDLYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSM4</accession>
    <name>A0ABR3BSM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_103267</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614151.1">
        <property type="nucleotide sequence ID" value="XM_066757767.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990123"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="9"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="238"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="272"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0249964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="324" mass="34041" checksum="145A18E7A2332121" modified="2025-10-08" version="1">MSTGSRCLVRGSINIDEFFHLPHIVRPGETISSTGLTKRAGGKGANQAYAVGRAGGQVELDGAIGDDGMWVKEMLESAGVGTDKLKVVKDEVTGRAVIQSAADGENSIVLHAGANYYLPSPTPAPSLSTYTHLLIQNEVPLSSTLAYLTAAGQSSPPLTSVFNPSPMLTPSQLREFPWKHLSWLIVNEGELGDLLLAFGSSANPGEAKADELQARASAGILELHENEYFSKNVGIICTLGAKGILYYEPGKEVGYLPAAKLQNPVKDTTGAGDCFAGYFVAGLMSGKSLQDALKACLVACGICVENEGAMESVPTLEAVNKRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSZ1</accession>
    <name>A0ABR3BSZ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614256.1">
        <property type="nucleotide sequence ID" value="XM_066757872.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990230"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="50527" checksum="B6086D72CDDC48B4" modified="2025-10-08" version="1">MAVQYLRRTHTRNSLPYDLLHIIVNLLISTESLGTLAILQRCSQAYYDLITPLLYTHVHIHSDDQLQRFLTLPSESRTRRKSKGFTLLSPKTIKRARSGSVQTSEKKLQALTLVKSLTLDAYPSRTSLKLASKLPQVIPAKFLTLTSSAVLSLHAKLLRSQAPRILATFWAGLLPSLIQPQQVTINYSSLDVRTLLQGEKKENWWNTFGGLSVALQHWEKLEKIELRGEVWGLIVPSPGVEMEMVHTSFMPNEAIIDEATMLDEGDESDGNNDMPQDAIHNSIPMQIPNPNLTALPQVANNNDNDNTDDTLTPRQKLLKDRKEAILLGLLANYQVVQHTRHQALATHPNHLTSYVPQHFITNGRRSRMLWKLRYFLPPPDSDVDEDGIEWKSDDEKREELENDRKEVAAWLINELDQQCPELARDYGRMVNGRRELDCLQWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT00</accession>
    <name>A0ABR3BT00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614269.1">
        <property type="nucleotide sequence ID" value="XM_066757885.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990243"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045477337" description="DH domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="60"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="432" mass="48360" checksum="83146A446D31C8BD" modified="2025-10-08" version="1">MGFCQFLASLLCVSKAQADTDSIFPITKDFITSCSSISSASTASTRTSNRPRQIPDTASGRTMVLQEFINSEKTYVDLLEQFDDIYIHSACAPLIFHTGGKLARELTFDTALTADERKTMFNGFQEILNLHRKLVLPKLVTATQVLLAQGDDLDGVRSTHAAFEACQVICKFADWFKMYSAYSATCDNATAKLTQWTNETDMARQDKNRVQAYLAKCTANEKHSQVNMTGYLLLPVQRLTRYKMLLEQLEHYTPAPPSGARDYIGEALARIATILVYVNDYKRDLDARSRLCHWADRISSVGPSPLVQPHRTLIREGPVKFIARGALPQNTSRTLRHRLVDESKRSIIGTVNKTCMAVLCQDLLVLVDNVASKQKGKSELIDVVRLSAMGKARVEWGNVVVFEASDLSYYLRVDHEETAQGWVDAINKSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT10</accession>
    <name>A0ABR3BT10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614272.1">
        <property type="nucleotide sequence ID" value="XM_066757888.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990246"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="478" mass="51000" checksum="36DC5710E2A7BBC6" modified="2025-10-08" version="1">MSILSDMPPRSTLPAPRQSHRSHVPLSQPKAPATQPSSRPATPSRSRGDIPRKLSQPPSSSRPYSPTIDMSDNPPMTPSPRPQRKRRGGNKPSTQRAQASAPAVMAVDDEIVDRESGNSGEDYAQEDEDALFDLLGVVSPPKSVELHAQLESRPGLIVLPKGEGPNAVKMPRKARKSKKTAGQGSDLFVKDDDGLQQHAGVPVDPAPKKKSKKLTKPPLTATASAPPGPVQTTGPTPTLDQLLASAIPTAPSPKPRAQRVQRAQDDSTFEMSSLSQNLPSDLEGAGNGQQKKGKSKKKENASAVWDMPDAAGGDELTWQQKLAQTETPTRASRKPFQSERSERKGKSKLSTLYDPNRAANNCSSVAQDRQLSYDSIPTQLAQPILTAQQRLPVSAFDGHIPFHTGFNVHRAPQTPAKSVASVHGNLLMGEGALPVIPGEFPRINGAGGVPVGGPKYAGPTFHNSPHAATLSKPDLEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT19</accession>
    <name>A0ABR3BT19_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter ABCC.6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_103398</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614279.1">
        <property type="nucleotide sequence ID" value="XM_066757895.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990254"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1004"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1043"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1131"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1219"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1257"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="328"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="678"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1046"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1339"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="914"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="930"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0250092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1623" mass="181023" checksum="5FBC6D4663CF3805" modified="2025-10-08" version="1">MWPQALPTWPVVVDTICVAAVLSTVLISLLQLIVAWVKNTRGGHIQLSESFEPKSKKELFETKLLYHVAKETPEDGEPVEVASFWKGTIFAKALLTLVTFSSLAIQIVETIESPPYRGESWLYFLRLITVSLTNIHLVALSTHYLTTRNLNRHASLTKHICTISSTLLLHWYFQTLGQYLWLSTNVHIPWTGYTSLGLAFLQTVMSGLIPVGPKLWVDMTMIYTKAVRAKVEDSAAITFGGNLIEETSCSIFEKLMFTFVYPMIIKTAKMHQVDIQDLPALQAEMRTQNMYHEFMGPKTAEENRWKRHPTLSLLWTVWWPQRRAVGKAFIFMFALCPLWYLPHICLQQILSILDDHTAVRWGAVAFAALMVFAKIGNMIITIQQYNITMSYVGPRINAHTSFLLYQKLLTRNLFAIPEKKEGDKAVHTKADILNLISSDASSVQRVGWTFTNLFRSAVEMALGCSYVWILLGPSGLWGLSTLILTCPPAYLLTKWEYSVFEKRLAIRDERVSLMQEAVQAISMIKMMATERFWYRRINRVREREFKKLIQAQVLGYISGLLYSAAPTVIVIVAFAHYTLVAKNELTATIAFTSIAVFDELRPALLDLPSSVAELLQEILGARRIANFLTTEDVEYFTDTSFNPSDPSSSENGPLYVIGTVAWDVPKVYLAPPSNPTADASSDSSENSKIGFRLMDLDIKFPRGKLTLVAGKFGSGKSLLLLALLGEARLIEGEISYMVSPIMDPQKIDKNDWSLFKNGVAYAPQTPWLLSQSIRDNILFGLPLDMERYRSVCFATGLMPDLELLEDADLTEIGERGKLLSGGQKARVSLARAVYSRASVLLLDDVISAVDAQTSQHIIKHCFSSSLMSGRTVILASHAVESLASLAAHAIYLDDGRCLWQGSGRQLLETGHMAHLKSESRSPSRLPNRLPSRERLKAEPKINRKDKKKSEKPESLDVQAAKGKFEIREAIPKTPKQLVIEEERAVGAVDLIHWKNLLKFNGNGVYWGAAFTLMMAVVLAPVCERKVLSLWTGTEGEISTNHTVVFWISFYAALSLARIFLDTVYGLFRFWGSMRAMKIIHGQMLESTLHAKMLFFTKTRAGSIIQRFGKDLNDILDCSNLLTEMIEGGMNIIISLISVSVYGGWTFCIVTILLLVAAWTPGKWYRASSRQVRRLQAVLPGPINAIYGETVAGATVIRAFGAQSVFIDELLRWSNMKITATIWTIAIARWLFLSLQVMDVIVRITALSLLLARASTTGAVAGFVLTFAGSISTYVNWMLVHLRNFELKGVSLERTSEYRTLPREDGTKLLADDTRYATDRQELDEEEDQLLGSWPEYGELKVEGLCARYGPDMPEILHDVTFKVKGGERVGIVGATGGGKSTLAKAFFSFVDITKGKVEIDGQDISTIPLGVVRSKLGIIAQDPILLSGSLRLNLDIEGKYSDEQLYTALRQVQLLKQSDSCPDLLSNDLTSSSTETSSQQENIFSNLDFEVKGGGENLSAGQRQLVVLARALLKRHRVLILDEATASIDSATDAEISRVVHEEFTNATVLIIAHRLRTIMPCTNILLMDKGNLIQQGSPLELIHSEGPFQDLCMAAGKEEYKHLIALAEEHDPSNKGDLVDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT51</accession>
    <name>A0ABR3BT51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614309.1">
        <property type="nucleotide sequence ID" value="XM_066757925.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990286"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="431" mass="48352" checksum="636386B09C23EB1E" modified="2025-10-08" version="1">MPLRTSLPRLRPRPALRLYSTRPPPPPPPPPASRILLGCATTGFLVGLAIQLTNTYKSHTRCDSVAAVDAIETHGFPWHPVHAVENDDPANPMRIRMATWVKSLQDHIVKTMEHIEASAPPNDFSPSSTPPTFLRDAWIRPEGGEGSSCVLADGRVFEKAGINVSVVHGKLPPKAQKAMLPDHPSLPEPTTTVPFFATGLSIVIHPRNPHVPTVHLNYRYFEIEDPEQPGKPKAWWFGGGSDLTPSYLDEADAVHFHKTLKQACDQHDERYWPDFKKQCDKYFTITHRGECRGVGGIFFDDLTTTSPVHAPPTDSPAAGPSAEKIFEFVKSASSAFLPAYVPIVYKHMNDEWTPEEKRWQQLRRGRYVEFNLVYDRGTKFGLNTPGARIESILMSLPETARWEYMCPMGKEGSGTREEKLLQVLKNPRDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTG3</accession>
    <name>A0ABR3BTG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613278.1">
        <property type="nucleotide sequence ID" value="XM_066758830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991209"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15789" checksum="4EF102A835D662E2" modified="2025-10-08" version="1">MSVNLSTPSRTTQSQVYSAHLRNALLPELDNTRQRLSTVETDIAEYALLKDNLVGLQKEQGKEVNTMSEMGAGIWVHTTIPDISVITLDLGFDLHLEMPLADAEEYVKKKLEILKKKRDSLSQKEEFLVWQIGQFQGAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTL9</accession>
    <name>A0ABR3BTL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614486.1">
        <property type="nucleotide sequence ID" value="XM_066757017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989329"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="513"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="657" mass="72719" checksum="7903C2106AB3E5D6" modified="2025-10-08" version="1">MSEAAGPSSNLGKRARDGDSISPVPENVNNDGSEVPEMPPADVEDSSDDEIGPMPGGDVVISNGRKKRRTVLPHEKLYLASLPDTDRYYKSFMHREPLNSITMARTNFLITTSIDGHLKLWKKQEQGIEFVKHYRASLKAIVGVSVSDDGKLFATVSEGGEGRVFDVVNFDMINILKFPYTPKACCWIHEPGAGQPLLAVSDIASPTIRIYDGRGDGKPLYELNKLHRAPVHLMVYTAKYDCVVSADEDGFVEYWQPGEPWGLPSVPGLWQYKSSTDLFHFKKAKTIPTSLTFSPNSSHFVTLALPSRAVHIFNFLTGKLTRTYDESLTAVMEMQQAGTAVFKLDDMDFGRRLAAERELDKSESGPGGLLRTANAVWDESGNFVLYPTMLGIKVVNTVTNKVARVLGKDETLRFLNIALYQGAPAKKGVTTVQMAASANPLLQDKASRDPHLFATAYQKQRFYLFARSDKEESKGERDVFNERPTREEQTVAVPVEEKKRPSAKRCTIHTTKGDISVQLFPDEAPKTVENFITHARNGYYNGTIFHRIIKKFMIQGGDPFGDGTGGESIWGGTFEDEISPKLRHDRPYTLSMANAGPGTNGSQFFITTVPCQWLDGKHTVFGRAVGGLDSVDAIEDAKTDKNDRPFEDISISSITVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTY0</accession>
    <name>A0ABR3BTY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614587.1">
        <property type="nucleotide sequence ID" value="XM_066757118.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989430"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="407" mass="43892" checksum="67A7DC71594985A8" modified="2025-10-08" version="1">MKRAARLVPAVSQPLRPCARPAYILRPTPGPSSSPLALHAFRFASTAPPSAPAQPLESPQDLPPNISFEGLAQEADGEIERALAESDANLATWFPTQSGLHEPILLPVSSLASSTPTLPSDSNVVIALPPDVFAQPIRRDILHRCVVWYLSQLRSGTKSTKSRSTVAYSGRKLIPQKGTGKARAGDASSGTRRGGAPIHPIFPKNWAQALPRKVRDLGMRIALSSKLQAGLLRVVPNLNEAGWKGTNEAKRALADGLAFPEAEASEKVQATKSDVEPLAKDAVEAVEKVNELEGTIPELTPSAIGPVSIPRFGPVKDLSVLFLYSPFKPSDEIADFIRVTRNIPGVEVLSTEEVQVYDILKYRWLVMEGEAVDWFGNDVFGVDGFEGFEDTDGVEAVDLAREEALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU60</accession>
    <name>A0ABR3BU60_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102658</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614667.1">
        <property type="nucleotide sequence ID" value="XM_066757198.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989514"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="158" mass="17134" checksum="070C25CBC85F4784" modified="2025-10-08" version="1">MSDYAFRKIDIDALDEDVLLPSDLYDPDPRGPDGVLEDAKRRSAEVRGLVSRGDVTGALNTILTDPPYGDGVDEAKNLTTSSLLLILNSTRSADIPNLIKNLDQVQQDRLMAYLYKGMAALGQGGEVSGSVLLTWHEKLTEAAGVGCIVRVMTDRKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUH3</accession>
    <name>A0ABR3BUH3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614779.1">
        <property type="nucleotide sequence ID" value="XM_066757310.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989631"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="158" mass="17111" checksum="3589D8B9AD05CC95" modified="2025-10-08" version="1">MPSLESAGSYTTLSGTTAIETGTITHSSTGSASQSTTSTDYIYSYATSKIVKTAVAAGVIVLCLAAIVLFFKVSSWIRVRQSLRRHRLLTLSLKSEQQAAAYEIAAWADEPSTVPARSVGIRGDKEKKSRKERKEELKAWKRGGANAWALQEWEGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUI8</accession>
    <name>A0ABR3BUI8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614530.1">
        <property type="nucleotide sequence ID" value="XM_066757061.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989373"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.580">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="85161" checksum="6631E9AF8F043B38" modified="2025-10-08" version="1">MDTPASNTEAPPTPSPAPPQIPSASTTATTPAPAPAVASAPIKKQYNKRVNKKKVEGLLAYTTAFVPGTYNVKIPAGDYLQKERNADVARQMSLDRAKRGEEELSSKISDGERENPLSKILVIHPGSRNLRLGLASDFYPKEIPNCIARPAEAVQISGARKAPVMGSRVKSLREQHERNKKRKRGEMDEDDDHEEGDVDMSDRGDVGEWVDPVDESIGYLRDYLRNRLVQERLATDWRELTRVKANNSKVKPELLPEHNDPYRIDWTEPEGKPFFIGTDALRLPESAGYTVRYPILHRSLNRRDWASSQTVLDDISTIITSSLSTELSIPPRDYPLFSVLLIVPDHGDRVYIQEMTHLILQVLGFKSIAVQQEAYCAIFGAGMSSACVVDIGAQETSVTCVDEAMLLAETRVKLNYGGDDITSALTHLLLASNFPYRELDLARSQDWLMMDNLKIKLCTLEEHLVANTLWDFYVPRVEGLTQKWMLRTFDENILAPLIFFDTRMIDFDEKNGQGSFRFWNTSDDKVTDEITSAYEEPTSAMKALTTHLLPGPPQTSAQGAQKSEAPSNSESTTPAPAPLAASSNASPEKPNASPSTTTLPQTPVPELNLPSTASTPAPAAGSAADAGTPGAAAPAPALLSLPTLASLAPQPTLSNSQIFTASSQSPLDAAIAASLSLCGTENKIRTLSHSILLIGGSSSIKGLPAFISDRLPSLLKQRGVPGNGEVTIVPPPRGLNPRYVSWKGGSVMCNIEGLGDMWIRRDEWEALGVRALKDRYMWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUJ5</accession>
    <name>A0ABR3BUJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIP1</name>
        <name evidence="7" type="ORF">I308_103425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614304.1">
        <property type="nucleotide sequence ID" value="XM_066757920.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990281"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058999">
        <property type="entry name" value="EIF3CL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26569">
        <property type="entry name" value="EIF3CL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="625"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="823"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="856"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="886" mass="98835" checksum="B02B09E957BA3D8F" modified="2025-10-08" version="1">MSFFAKLQGSDSESSSGSDSEESILSGSEGERQDKKLAAQKKQQKSKASMFLNSDESESEEESSDEEEEEMSDSDDERQAVANKFLMDAGSSDEESEEEDKIIVLSAKDKRFAEMEAAIHNIQNAVKNTDWVLASSELDKLFRFITRHLVTIVASPIPPEGHIPPRFLETLVFLEGDVAKTLAAEKSASKKMAPAKAKAVNGIKQTLKKKSKEFEGVLKTYNEDPEAYASAYEKANAAPAAPKPAKKSTIAAPGEGEGDEFMTIGKGGKTLNLTAEGVFKTLREIFEARGRKNTDRAETIKILTKLLEVSETTYQKIRVLLALVPARLDYSQHLVSIPQESWVAALQEFDQLISILIAEPDYLVQEIVGEYDDLVDRAPEVVDGKKQKVLIAGSLISLLESLDSELTKTLQHTDAHEKGDEYIDRLKHEAPLYTTIVKAQTLFEREHLSDNIARTVIRRLEHIYAKPDIIIEHFESKATQAAAGLKSEITPFDVKRDASGVIHDLAVFIYQSDAPVLRARAILYHIFNQALHGRYHQARDLLLMSHLQDTISHADVTTQILYNRAVMQLGLAAFRLGFIPECQTILSEMFSTMRQKELLAQSVQRYNIQLSPEQELLEKRRLLPFHMHLNVELLEAAYLTSCMLIEIPLLASVDTEEQRRRVTSKTFKRLLDMADRQAFMGPPENTRDHIIKASQALQAGEWEKARDLIVSIKVWNLLDNAAEVKDILAKKIQEEGLRTSLFTYAAYYDSLSLSHLASTFNLPVGRITSIISRMIYADELTASLDQIDGVVIFHRVEQSEVQRLAQQLAERTASMLEQNEKTLDVKLGNQGQGQDRDARAAGGEGGRQQGERRGGRGTYRGRGGRGGRGGFNQGLGTTMGRRVTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUJ7</accession>
    <name>A0ABR3BUJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614545.1">
        <property type="nucleotide sequence ID" value="XM_066757076.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989388"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="199"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="363" mass="39877" checksum="B56ED18DA4A412F7" modified="2025-10-08" version="1">MASKIDLQDHTILVLPFTPSLLRDPSPLYSPILDLLPRSSKKSFTVFFSTPAGAISSEQSAIQSIPGVGSNQEQLYSLLKRAPQESFKTLQSFLGHIYTALWTAQWKCENVLLDVEVHFEGESGELGAKLLRGKNGEEEYQVIKVEGVQETDLVGSLDGIIPSPFTQLSLPFASLSSLRSEPYTISNQGRTPGFPVVALGGTFDRIHAAHKFLLHLGYFLAREKLIVGVMADDLLQTKTRADLVQPLNQRLDGVNAFLARLGDGSIKLDVLEIHDALGPTKSDPNVQALVVSRETLSGGEYVNVTRKKSGLQELELFVVDVIAESEDVDLKEEVDEGKLKKMKMGSTGMRNWIAERGTGEQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUL2</accession>
    <name>A0ABR3BUL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613980.1">
        <property type="nucleotide sequence ID" value="XM_066757596.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989951"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="359"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="640" mass="71275" checksum="2CA4E071C008D882" modified="2025-10-08" version="1">MAHNLSAKLVPSISPPPPAAPSRDSTLESAGQAADIFDLYGANEESMRGSWEGPMDALHEDRDAGQEQLDPLSGTTPNINIITSPPAPPSPSHSQSPAHSRPHTPIKHRFPSIRSTRTDSTTNSPVPYNDIQRLSPANTSSKRGSMSTEIFSGTDGTRSQTSIAASSRYPGEEEDAFHVRSTYARLGSEGVHGDGWDQGVERTRGGPTMADKRVTVFPAAKAGDIGEKERQFLASLDRYGFVNDPHRNRSESRVASIPSASLIKIPKMPTTSPLSEHPPVQPNHSFNPSSDPGPAPKPPKSPRTDSDAEAKKKRKESERAMKWGKMMKVKRRDGGGNIIEWQWSRDGQGAKLPNRVYKGIPDRWRMAAWWTLAEGQAQKWNGKGKGKSTLQELAGDYIEAVHLPSTFDVQIDLDVPRTISGHTLFITRYGTGQRNLWHVLHAFSQLCPTCGYVQGMGPIAATLLCYYDPERAYSLMVRLHDVYGMHEIFEPGFPGLLEAFYVQERLMNWLIPDVYQSFQRNMISTTAWGTKWYITLFVNTVPFSQQLRIWDALWMEGRDAIIITSLAILWSFRDLLAGPNASFESILSLLSSYFVPEDEDVFMQWIKKVLSQKKVRGKMDGWRVEWKGLVEEGKSGSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUR8</accession>
    <name>A0ABR3BUR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Splicing factor 3A subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102866</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614870.1">
        <property type="nucleotide sequence ID" value="XM_066757401.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989722"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="10">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="10">
        <location>
            <begin position="169"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="701"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="569"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="341"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="85440" checksum="A8607EE01C8F36A7" modified="2025-10-08" version="1">MSALNLPKPVNTYAGEDDLRNANGVAGMPNGQAVQQNGDAEEEWVPPKASDKLKIGIIYPPKEIRNIIDKTANHISKSPTPLLLEEKIREHQKTDPKFAFLNDADPYHQYYRYMIVKSQEDAEDAAKGIVKPQEEKKEEKEDERPKATEPKPWEFKVDLPGVTAMDLDILRLTALFHARRGRSFLSSLSVKEGRNYQFDFLRPTHSLYGYYNRMVESYQKIMQPPPGLIDGIVKEANDPNWKWHTLDEARNRAEWEKNRRKRENERAKEEEEEAKAFAAIDWQDFVTVETIEFTQNDEQLELPPPTSVEKLKSMSMAEKRMAAMVMEETGAGPTGETAPLAEEMEMEEDEEEEEARLQRIKAEQEQARAREVQRAAMEQRGMKIKKDYVPRGIQRTNAVATAICPNCGQSIPENELTEHMRIELLDPKWKEQKKQLELRRAQAQQLQQGADVVSSLKNLASARTDIFGDDVDEAERKRREEEERQRRREREKIVWDGHTASAAKTTETFQSQFNLDEQIKKLHNRAGLTDQPANAPGPQIGPGITQQAHVPTPLAAGLSTPGGGTAYAGATISAAPTGPTTREYISTPYDPSFGGTPPPAPGSAPSIHPSRLAAMGGNTPYLGSATPPVAGQVHPRAEDEGAGDRPVFKRPKIEKLPYGQLYTEIDWQSLHPEPVSIAVQLPSMPEKPEWKLDGSVITIPDLPVSTLFSTVRERIRRILDTDVPVSRMRLDYGNKPMSNSSTLASVNLDEGDMLSLVVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUS1</accession>
    <name>A0ABR3BUS1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-deoxy-D-gluconate 3-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614857.1">
        <property type="nucleotide sequence ID" value="XM_066757388.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989709"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="13"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="275" mass="28947" checksum="8A674271BEEECF12" modified="2025-10-08" version="1">MSYIEDLFGLTGKTALITGATRGIGSRMALALAKAGADIILVQRNTSNTSTRDAIVAAGRKADIVVCDLGDAAAVGKLIPHVTKELGRTLDIVVNCGGIQRRHPVENFPDDDWNEVLQVNLNTVFTITRDAGRHMLESRGGVAGEPVPEGGAAGNPRGFGKIINISSLVAFQGGLNVVAYAAAKHGVQGIVKSFSNGWAAKGVCVNAIAPGYIATDMNEALIADKDRARQILERIPAGRWGTPEDFEGAVVFLASRASDYVTGECLFVDGGWMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV07</accession>
    <name>A0ABR3BV07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613833.1">
        <property type="nucleotide sequence ID" value="XM_066758431.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990806"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="4">
        <location>
            <begin position="883"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="769"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="946" mass="106734" checksum="673DB258E098043C" modified="2025-10-08" version="1">MAENILGLLLVTSSSRGRHVFRYPPDPASPNVRLAQPIYPSATFTATEADVEYKHPRAGGAGMRRRPYDDLSSNASIRRSLFGPSTRGSSKTGRDRKGKKKADDIRARYMNTLEEANGSDYEDEDSEQDDSSSDEGSDFEVMWKPATTNGANDATGTGSTKVAHRQASGDDDQRASGVRNLEPSVLDASRRGSTSTTTATITGADRNNDHADKDAKRLAIESQYNYALGWPLEVLADMLTPPRSACNRRFELCVGNVVFLGHPVCASPDGKWEVPPDEDELEERAPSRGRRMRDQGGTMTNLDTVDEGIEAYTSAITQHAKTELEAKRSSDSSHKDDDVPNLTMFHLVLIIDKPDPKPGTESHDEHHSQAMDIYDEIYREIAFKWTAAAFNLQCESNLVAREAWMIVKYKDKCLNEGIGITECCRWTATHSHIDRTLNYLYLRLHQLRTQPANGLHSYLPTTITSRLAHIPIQTVLSPKPVNTDEAWAHWGEMEEMLSDKDSEESLSDWEDDWGGGAVMGMKRPELIVKPWQTLLLIDEDRNQSQEALFFGIVGLPAVIDDDDALDSKANGRKSPVKSRTRRGSKITVEDNVTEDSETVLRRTLIEACDVTKPLYEIAHLLRYDLDGVVIPLARDLVQSKRAILIDVVNPRLRTVVMPTTIDEHNSSFDQYTARFARDFPNLPPFPRFISAISLSPIPFRKVIPNPDPDHATREKYMSALLWLLKQDLVVQVHTRARVFAKSEIKVEAWKRLWYRRRQRWIEITKERTEREKALAQSPSEHSDILTPRASESHTNPLDATTFSSLGTTPIANTFTVPLSNGNSKLEHSYMDYDPALEMDSDEEFDGLNGPQKFSLDAAHPAKHEIPNFESSFIFKPARAQKDEARWLRVIREKADEVWASKFDLCVQYFDGVTTFEEITYRTGLQRKELEKILQLYNGDVVTFVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV61</accession>
    <name>A0ABR3BV61_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613878.1">
        <property type="nucleotide sequence ID" value="XM_066758476.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990851"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047168427" description="Serine carboxypeptidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="63198" checksum="0329148169A6C101" modified="2025-10-08" version="1">MYYLHLLLSSLILPYAFASPTLDPHLHRQLLLSGRPQIGLWKALLREQVAREASSSESTVDRQLQQPFQIIKPSPSIFEPHCFPQLISHFDDSVNGTFCQRYWVDASSYTPGGPVYLLDGGEINAEYRLPFLEKGILDILSNATGGLSILLEHRYYGESVPVSSFSTDDLRFLNNAEALEDSANFIENFKLPSSLVNALPFELEETAFHPNNTPWIYYGGSYAGARAAHMRTQYPDLVWGAIASSAVTHAQIDFPQYYDPIQEYGPRECISTLQRAIIFIDNVLDHPRATGFPQLLKRLFGLGALEDDDFADVISSPLGYWQEKNWDPAVGSTEFYNFCDALTAGGGGSKIGLIRVPASVLNYAKYIKENVVSKCPRTPGEPDSDIEDCFGTKDPEKFRETDLSQIWRLWLFQVCTQWGYFMPAPPSASPRIVSSRLTLAYTSAICPLAFPPGKNFTIPSQPDVEEVNSRGDFAIEANRLAFIDGDRDPWRPMTPQRNGVRGKKGGMDVNKPGWIIYDGVHHYDENGLAQHEAEPARIQAVHEWETKFVSAWLEEWKIKQGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV66</accession>
    <name>A0ABR3BV66_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615002.1">
        <property type="nucleotide sequence ID" value="XM_066756225.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988529"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="193" mass="20981" checksum="B530ACD5C72CEF27" modified="2025-10-08" version="1">MSVAPSRSAPPPPPSEDDSQGASANERLLAAAKTDNEGMLEDALKELSDVNQPDGLGNTALHYAIIHASTNVLEPILCHDTCDVDLKNRLQGDTPLHIAVRNRWDQYEGLRLWLVRSLLEAGADTTMRNRHNERPIDILPRADPNADPSTDNEKIRSALRQAEAEASLALSDAVVDDDDEAEVDPDDVASDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVG2</accession>
    <name>A0ABR3BVG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615082.1">
        <property type="nucleotide sequence ID" value="XM_066756305.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988609"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0252362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="347" mass="37754" checksum="25EC648F104E3FC9" modified="2025-10-08" version="1">MNRPVSTIRLVLSATQPRFVPSPAIIRPFVSSTRLYATHRETVSPHSQSQATSDLLKGLGNKTGTASGTQDTVGPFPLGVGPNGRRKTWKSWSDLNIGGKLVRTTQQTGNLTVILFGGALFVVLAFALTTELFAKNSPSVLYSRAIDMIRGSNALDAYLLPPLKFTHSPHSSAPVRGSPPIAHTFIRNPTSGKDHLVISFWIHGRGKDEEETLGWIKQGWRSAVAWGKQGVEMLVGEKPEDVVKEDVEKKEQLVAKQEPGMLSRWFGGLNLRSPVGSRTSSAKELPPAGTYTVGEARGEYVKDEAGEFQMLSLIVDIPSSKVSYPGRAVIFQSPEAETEGLLGKRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVI2</accession>
    <name>A0ABR3BVI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="10" type="ORF">I308_102621</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614634.1">
        <property type="nucleotide sequence ID" value="XM_066757165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989477"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="148"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="286" mass="31269" checksum="01945099BA981D04" modified="2025-10-08" version="1">MAQQVEEIEQDLSHIHWSWPEAIAANPARSLATPDLAMDYFAYSPFWDSKSNNNVLRTQRRIENPAYGHAEEKVELNAFMSGFEYVVAHSLPPDLFVIHRREVESSGKRDRITGAWFILHEKIYQCPTLFDVMSTRLKNATSLISKTLGTLSENRPPANPRTTTLWRSIPSPVSNQPDGAQSPTSNQAKPDGEKQDGSLRGSSPLDGSDGKASPGGPDWHLFHALQATRASLASLEALAKTPAQTTNPREELKNIEIAMGSQLGGQNQSLSGKGPNVKGGTASVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVM8</accession>
    <name>A0ABR3BVM8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101852</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615180.1">
        <property type="nucleotide sequence ID" value="XM_066756403.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988710"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="404"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="725"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="728"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0252460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="844" mass="92051" checksum="E3FBEF6052A1C8FB" modified="2025-10-08" version="1">MPSPRAPGNESLPLSGDSPGLRVQWKVGPPMSAGQNEKNTARSSTPDSSLSKKKKKREIREKIINGFDSDSEDESDIVEETKPKSKTIGEVAEGPDLDGELAALVEEQEVDELEDDDADAIEQTRQKRSVSIDDDISGELLELASGPPKKRKKQTMAPPSTQRLLTQSERSLSKSQVPPVQVTSHRVPRQVPAPSVVPRSTPSALQHFPSTPNTSMPFIPGFPMTVSILSTGNDPYSSPLQNLAQSLPSPEMQNILFGTFFSDPILTEGLSLLQPQFMDHFNRFMERRSTRPQRGDATTLALTFIILASALRILPEETNRLLLASHGSSNAPSQVPRSLARIISGQSVATADITPLDQRYLDLALLSAQIAEQADTYSIMFVMFKLVSYRYWMLGHRREESVLAGTWLAQGIKVAQALGFGREWEGLPQGDRELRRRVMWSLYVADRQYSFETSLPYTILDAHQGIQLPSPLSEPDLYRVPQDARELPSVPPDSPPTPCTALLVHTHLARRVTAMLDSFATISASNISHDMVHHYDQVLETFQDSLPPFFKVFPMTDSRYDASFPYLPVQRVRLHTALFGYRCGLHRPHLPAYLWPTKSVTARQVVAQISLSSLRVQRSARMLDAKVAFRLFSPVTVFENATTLCLIMYIDKAVSADAGLSPGPLRSAEFMSRRAGVAEALELLDMTGAGADAVAMFSKKATVVIRGMISQIDAPLEPILIPAPALSRRSTNGDIPSPSKSGTMPSGHQAHHMTSDSQARSAGPSPVASGHPAQPGGAPASNVTPVSSVGAKSAGTGSMDGPLGPYSAKAAAWLDSLVQGGPDLERLLREAEWVNGWERVIATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWG2</accession>
    <name>A0ABR3BWG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolus and neural progenitor protein-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615450.1">
        <property type="nucleotide sequence ID" value="XM_066756673.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988980"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047205">
        <property type="entry name" value="RMP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792:SF1">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39413" checksum="E81E2866B53C7459" modified="2025-10-08" version="1">MLPYTSGYSTPVPSSSSLHFHASLPSHLSTELALLQTFIKRASAQHRSQLFLQRMEGILRVGKSMLLHVLKASEERTGEACIAWRWKGENLIKKMIKMLFSGHYITSQIIDLYHFLPLQTTVLSIYARLFTVTVSLANSLEMDVEQLLVVAGKATNGKRRMGPEENQKTDKVATGTLLAGAIKDNGVDVEMGEVIERPGSSQSLGRVSKSKSTPGSISERSAFSPKPPKRGKVVPSAVAALSSTVDSGINLENDCLEKETTIVSKSVELPASLQIDQLLDNIPSTNIAKDKKKKRRVETGINVSDAKAPKEDVSIEDDSFNKKKKRIVKDEEEGKSDEKTIAKKKKKKKDAMDDIFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWM3</accession>
    <name>A0ABR3BWM3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614685.1">
        <property type="nucleotide sequence ID" value="XM_066757216.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989532"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047089966" description="DUF7729 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="3">
        <location>
            <begin position="58"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="272" mass="26770" checksum="813916FFB0B78917" modified="2025-10-08" version="1">MRVVSTFLILAASTSYAVALSAGCTTQLGVLALGGLGSCLQLTSLLPVLTSSGSVVDPLNSYLKSLCSSSTPTCSNDTLTSASSSLNSSCSSDLNDGGTNGAEVKALLILLRDYSQVHAAACSTNSSTGDYCVTDTLNTIQNASGSNVTLSSVASIISGASSDTSNITSVFSSGQLCTQCVSGMYYEALQANSSVGNTEIGKALTSKCGSDFGKTSPNTTATSTSGGSSSPATSSASSSSGFVSAQYAGLAASAGIAGSVLGAVIIGSTFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX29</accession>
    <name>A0ABR3BX29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615673.1">
        <property type="nucleotide sequence ID" value="XM_066756896.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989204"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF24">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="77"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="525" mass="58335" checksum="B56BBB39B8C0A388" modified="2025-10-08" version="1">MTEKSETQAAKPQDVEHFDESHHYNTALEDLGLTKEQNQLLSDNYAYVWKKDDSGNLLIKSAKGDPTNPRSWPSWKRYAIVGLASLLNNLVCLCVSGYSTGIEQMQEKMGFSSEVGTVGLSLYVLGFAVGPMFLAPLSEYWGRRPVYIVSWTIFTIFQIPLALAQNVATILVCRFIQGVAGSTPLANTGGVVHDVFAVKEAGYAVAIYALSSADGPPLGNVVSGFLAQNAGFRWLFWAYLIIFGFFLIVIFFFLPETRSTIILARKSSKLREATGLPFYGEHELAKKAPGHLWKVTIVRPFKFLFTERITYLCAGINGFVFGMIFLSNEAFPLVFGSGNNGHGWTHSGVVNLTFGAYVVGSFLGFCLTPLQEAWYHKASKIKGHGDPEARWWSALWATPFMPLGLMIAAWTSYPNLPWIAPIIGFTMFGFGFYIILAAILNYVVDGYGHYSASALGGVVFIRNIIGAIFPLFSAQMFKGMGNQWALFLLSMVSFLMIPIPVYLYYRGKVVRDRSPYCAKHYNDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXE2</accession>
    <name>A0ABR3BXE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ornithine decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102176</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="6"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615504.1">
        <property type="nucleotide sequence ID" value="XM_066756727.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989034"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="10">
        <location>
            <begin position="113"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="511" mass="55304" checksum="E5407B3E9B86CDE9" modified="2025-10-08" version="1">MTNTTIRTYMAPAAPVSTQQSPWAEQQPLQSRSTVSNLVKTLDPAAQIPYIPEVALPTPPATATPSIISNNEEHPALAPVADIPVHQLVQQTIAASTGVDIDESAFFAADLSAVYQAVQMWRASPIGSRVEIFYAVKCNPSPAVLHLLSLMGTSFDCASSSEINQVLSLPSAPSGDRIIFANPCKPASFIRTAAQRGVSMMTFDNVDELYKVKRICPNAKLVLRMLTDDSKSLCRLGLKFGAPVDSCPGLLKVARQLGLNVVGVSFHVGSGCKDPMQFADAVWRARKVFDMGKEAGYDFDLLDIGGGFERETFAEMTQVLKDSFDLYFPEDSGVRIIAEPGRFLVSSAFTLATSIIASRRAPKAEASQQAQAVTKEDTKSADVMYYINDGVYGSFNCIMFDHQIVHPHPLTIGHKLATAAPPFPPPPNVQLEVDLPVQMGYKDVEKLVDLPKGMDVGDWIGWGEMGAYTLCAASTFNGFDRSPVLWTTGGDTEDARVVRAILDSFSAACLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXH3</accession>
    <name>A0ABR3BXH3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_102218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615546.1">
        <property type="nucleotide sequence ID" value="XM_066756769.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989076"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045403501" description="CN hydrolase domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="301" mass="32899" checksum="3359293437FAFE28" modified="2025-10-08" version="1">MAKIQATPFRLALLQLGGLTASKASNISVAAKAVASAAASSPKPQLIVLPEIWNSPYAVSSFREYSEKIPEVGSKWKSLKEGEEGETIKALREMARSSGCWLIGGSIPERDEKTDNIYNTCTVYDPEGTLVAVHQKVHLFDIDIPGKQTFKESDTLTGGSHLTTFTTPFGKIGLGICYDIRFPEMAMIAARQGCIAMIYPAAFNTTTGPMHWTLLQRARAVDNEIYVAMCSPARHPEAPYQAYGHSSVVNPVGDVVVEADHEPTTIYADIDPELLATTRRSIPVTVQRRFDVYPDVSSSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXX3</accession>
    <name>A0ABR3BXX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101772</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615101.1">
        <property type="nucleotide sequence ID" value="XM_066756324.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988630"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0252381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="257" mass="28774" checksum="679AF427CCFA20AE" modified="2025-10-08" version="1">MSEQTFNSPVVLPKTDQYDPRGSIPNTVFAVGLIAAILGAVGGSSLALASQSLLNVFSGAWARPQLGIYLGAMCVFHLMEFFTTAGWNPQKLSVDAFLLNNGRQYHYAHAIGLAEYFLSSWLFPGKWDTFLGSFPWLTLVILGMVVAQGIRSLAMIQAAQSFSHIVKSKKHDDHMLVTHGLYSWSRHPSYAGFFYWAVATQLLLGNIVSTLGFVMVLNKFFSARIVDEEKWLVKFFGSDYVEYRKRVGTKLLFYFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYQ2</accession>
    <name>A0ABR3BYQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615119.1">
        <property type="nucleotide sequence ID" value="XM_066756342.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988648"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466:SF1">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27983" checksum="EDD1A85B04789665" modified="2025-10-08" version="1">MCAHSLFASHTELALKQLGLCHILNGETCPPISFAHFASFLTNNDYTSENLVFVLWYRDYKSKWKLLDKAVRIRVPVPSTSLGHRHDPFGYLRHGPELYLPGLVNEKRETCLEASTAPESFLPVLEEIYHTLESQCLPRFLEGVKSNINRPKQLFWYRVGAVDLLIGLTIFLLLTFLLPPSPFSLRTYRLFSTIFVSFGIMQVYSAYRRFCSQVWRRSNRQVWPWELDALEDENSEVGDTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYY1</accession>
    <name>A0ABR3BYY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615824.1">
        <property type="nucleotide sequence ID" value="XM_066755538.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987835"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF7">
        <property type="entry name" value="ZINC BINDING OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="17"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="359" mass="39365" checksum="B55409B86640CDB5" modified="2025-10-08" version="1">MVSDSIPQTMKAWTQNGDDWLSINQIPVPRLKDNHVLIKVEYAPQNPTDWKHAANISLLGDILGCDFAGTIVQLGPNLKVPLKVGDQIAGCVNGGWSNVEGSYAEYAAIESDMCFVVPEGMKAEEAATFGIGWVTAAQTIVYQQGKSFPPGDTKVSGNPWYIIYGASTSVGLFGISLAKALGYRVLGVCSPHSFDLVESYGADAVIDYHDQQKAIAEALDITKGGVEYALDAISEGDSFKIIVGMMGDKGKQLNCILGVPEEVYRINPKLKIEWTLMHTMWGVEFDWAPRSEKHEIWPVRPKDRAFGEEIFRRTPELIAKYNIRPNPISMRGGFEDVEAGLKDLQSGKISGKKLVIKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZZ0</accession>
    <name>A0ABR3BZZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615965.1">
        <property type="nucleotide sequence ID" value="XM_066755679.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987978"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="5">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="321" mass="35540" checksum="71E6968A9FC29696" modified="2025-10-08" version="1">MQHADPLPPYESTPVFFPDFADASQPLLQLRACRPNGLLPCPAAPGWSLDVNDLLILHPDAHKGDKAYTAWKLITCRVCGKTYDGKNGRSVARRHLQDKHGMPLAAQSRRSRWDLLRMTADEHRHEPGVKRKRLSQQAKLERIYAGFLERFGPRGLFTPFGVSLIAPKFRDEARDGSGSKPDDEAKDYLDGSYGSVIIPEEILRGVAAMRDDWDEDEDEPTHRSSSSSLPREGAPRPLNPTAQPIPTPTAASSTTVPIHTNSFYATDKSSGPPPLAQSQPASSSSRKESEVKRARIDPGENLEEAEKRVKAEGLIRKVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0G3</accession>
    <name>A0ABR3C0G3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Charged multivesicular body protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616112.1">
        <property type="nucleotide sequence ID" value="XM_066755826.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988127"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22173" checksum="A32FB829C5746C44" modified="2025-10-08" version="1">MSNLEKSLFQLKFTAKSLQRQAKKATKDEAAEKNKLKQALAKGNTDGARIYAQNAIRKKNEGLNLLRLSSRIDAVASRVETAVTMRSVTNSMGSVVKGMDKAMESMNLERISLVMDKFESQFADLDVQTSYMESTMSDTTAMATPQDQVDSLMQQVADEAGLEIQHGLGEAKVPAKEPTLGEATKEEDSNLAERLRALRPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0K1</accession>
    <name>A0ABR3C0K1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly protein subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616389.1">
        <property type="nucleotide sequence ID" value="XM_066756103.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988406"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0254168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32763" checksum="064081760243A38A" modified="2025-10-08" version="1">MASLAGFSSRAALSAFSCPTCTPRFIRSRSNFLQTVRKYSTFPSPKNAASPVGSRAQPRITAEEARRAVEAARQRMYQERAKKNRSIMLYSAGSLFLALGITYAAVPLYRAFCSATGFAGTPMTDTSRFTPDRLYVTPETEGRKRITVHFQSSSAESLPWKFEPVTKSVRVLPGETALAFYTAKNYGDKDLIGIATYNITPDKIAPYFAKVECFCFEEQRIRAGEEVDLPVFFFIDRDIVDEPQLDNLDDVVLNYTFFRARRNDMGHAVPDAPEDVIQKSQGFENYELAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0N6</accession>
    <name>A0ABR3C0N6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616408.1">
        <property type="nucleotide sequence ID" value="XM_066756122.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988425"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="356"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="525"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="718"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="857"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="865"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0254187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="947" mass="97312" checksum="7F43259A5E802735" modified="2025-10-08" version="1">MSPSPPEFEASDAYLALLARLARTEAQVSALSAQVATLSDLVRSAIPARTTSTLPAPSPPKRPVFAPFDSDPPLTAAPAAFSAQPTSYLSAPPKTPTGTSPTQQAAPSISALTQQITALSTSVAQLQRLQHTQTQQQSLTRQPPSSVAPSLHPQSSQQAVQQQQQQQQLGSSSLGGDRHPGSLSLGVPRLPSGGIDSFLGNNGPLTMPNSQPGGVSGTNPSSIPFGRAPSPNPNRPGMNRSFSSSVVQADGRGAHGHNYSGSGSHGHAHLSPGHLSLGGHGHQHQLGHGHGLHGHGPSALSRDWPSPGGQQQVQSGQKDGSTTPGGAAAPGGGIVVSKWEHLNLKVDLLRSISKYGIGPPNKIQTRVLPFMIKGSDIIAQAPPTTERIISYVIPALHICQGLPPPSGPYAGPAVVIITTTVDQAMQCHKLVRGVGGPIGIRSAVAAGAAGSSNVQNEIAQMQRDQIHLLVGTPAKICEVMTARGGLGGGEVRLLILDEVDQLIARNLYENVLNVVKHLPPPRGFGGALTPGGPPPAFSPGLASPYDAGQHSPFNPASKTPFPNLNAPHHPSRFGAPGQGAVGSSGAGAGAGAVGAGAGAGVGVGVGVGGGTGAGGESTTSGGLSAAGGASTNGNGIERQTCLFSNTIPTDVINFSQSLQVRDPVRVLVRREGGTNSQESVSSVTPGINLKHTYVYLTITGNAQQSGVAPVSVEVGPGTIGSGRIQHGQQGGKTSQQLSEEQTRAKEYKLDMLLKILDDYPLWQAIIHVGSFTMLEAVVYKLQTRNWETLYLTPEMPNAQKKAILQQWRISVSGSGPRFLVVFDVNVKPPEVPWSPLVINFDLPRSVEGYAQRAAAAVPPASATGSNGGNGGGGGGGGGKKNRGEGRGEGRAEGGASQGQGQSGQVNGVIVSFVQAAGGDVEMLRSTECAYRFKSAEIPTVFHDLFQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1B6</accession>
    <name>A0ABR3C1B6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101574</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616415.1">
        <property type="nucleotide sequence ID" value="XM_066756129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988432"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0254194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="64776" checksum="008FB424FB4DACE3" modified="2025-10-08" version="1">MFSMMLEQLPSLQLLTTTESILLALTVFALLWLLHVFVYKPFTSPLKNVPCPPGGTGSQGHIAEIMDLQGTKIHDWIKAYGSTFMVRGPFGVHHRIFSVDPRVLNHVLKHTNIYTKSDLLRDLVRRYMKEGLIAAEGERHKVQRKVSQKLFSMGGLKSMGQVVQDKSNQLRDILLNLCANPTASNPYSPVNPTLSPGCREVDVYSTVRDLFQKYERMQLLCPGAMGFRMLLSLTWPLIDKIWPSENTKRVNDAMGSLQKFAKEKMIERQLELATIDSKKGDVPDRKDLLTLMLRHNMAQKINAADKLRDHEIFGQLSTFLFAGGTISFDLYDLARHPDIQSRLRAEILECCDNLPFDHQIDELPYLDDVVKEIMRINPSLPGTVRQAQKDDIIPLAKRVTLTNGKVVTDIHIRKGQLVHVPIEHLHTSEHIWGPTAKEFDPSRFFTSAQSSAFSDQPTLGSHSAATSSARRDALPSYVPEGPGIWPNFMTFIDGPRRCIGYKLAVMEIKTIIFTLVGEFEIELMKGQHILRWNMMSNRPFVANTLWSKGSRLPLHFKLYKGGRQYEESGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3I9</accession>
    <name>A0ABR3C3I9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101458</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616300.1">
        <property type="nucleotide sequence ID" value="XM_066756014.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988316"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="163"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0254079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="675" mass="75139" checksum="89FD5A4154DB0851" modified="2025-10-08" version="1">MSNRKSVTQASAGHGYKQKSRYPLTAAMTEGKPVTQHVEEASSEKPTGIPRTSTDNSCSQGHPKKAIGDTLGPNGSNKVDLISNTNAKLANPLGDLTDEEVMENAAAFAAANHLPVEAFRKGALVGKRPNGFEQMSILTENDKAKLRREITHPYSQTKTLYNLVIACSVAAAVQGMDESVISGAQLFYPQQFGIGATNPDPKYANNHEWIEGLVNGAPYLCCAVLGCWLTAPLNNWFGRRGTIFLTAFFSFITCIWSACMNTWWLLFLSRFFLGLGIGPKSATVPVFAAECTPAKIRGSLVMQWQVWTAFGIMLGYVADLIFYHVPDKHNITGLNWRLMLGSAGFPALIVMAQVFFLPESPRWLMSKGKHEKAYKAMLRLRGDELLAARDLYYIFVLLEEEAAIVRGRNLFSELFSVGRNRRAMIGSTIVMFGQQFCGVNAIVYYTASIFTSAGFSEISALLASFGFGLINALFAIPGMLTIDKFGRRPLLLVTFPIMSLLLLFTGFCFWIPDREARVGCVALGIYLYCMAYSPGEGPVPFTYSAEVYPLYIREVGMSLATATTWLFNFVVSLTFPKLLTAFTPQGAFGWYAAWCALLFVLILFFLPESKGYTLEELDQVFSVPTGVHAKYQLWNIKWHFNHYILRSRESFKPLYQFDDDDEPSNVRHEKHDGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3U0</accession>
    <name>A0ABR3C3U0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616576.1">
        <property type="nucleotide sequence ID" value="XM_066754675.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986954"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="250" mass="28006" checksum="252FD8C8E2E2A3DC" modified="2025-10-08" version="1">MSKKTHIDQIVLIGDSLTQFALGERGFAAQLANQFQRQFDVVVRGFSGYNSRWVLEMARLFMPELKRIRLAVIWLGANDALLPPEPRAIDPEAYKANLAKLVSLVPLSAKVILVSPPPYSLKGKAKDLGLEYYPGINLDRDPAHSLLYNLKALELADNLNEAGDRKGNVAFCDTRSPMEKAALADSPGDLEGGLFKYLRDGVHLSPDGYQCMYEALLHVIKSRFPELVQEPYFFADYETVDHTQPEKYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C400</accession>
    <name>A0ABR3C400_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor 2D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616635.1">
        <property type="nucleotide sequence ID" value="XM_066754734.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987019"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
        <property type="entry name" value="SWIB_eIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26291">
        <property type="entry name" value="SWIB_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="3">
        <location>
            <begin position="412"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="514"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="66203" checksum="2164CE1E6313E5CF" modified="2025-10-08" version="1">MFKKPLAHQSNATPIRSSARRQLLSAILEQYPSLFAQDETDDDSKKELSKLILPEGVRIATFETSTGLEGTFWLSPNGDPLWMTLGRNSKEYIPTLFLLSLPLPRPPLPIIQIYHPLPPPILTGAPLFIPAVRNIDKPHRLPAVNKNQLVAFVTSPTKDDSVHYIGVGRVAAEGGMKGAWERRVNNLMDGGDREEGKFSDILCIVDDHLWDLGSKPTLSTFTLPPPQNPLAAPPEGFEPMPKSSSPPAIQQLSISAEDGSKASIPVSTPLSASEISSLLSLSLLQALSGLQPSAFPMSASLLYSSHILPSRPAYIPKAERDEVVIGKSDWKKLAKWMKEASKEGIVKIKESKGEVTVVSFDSRHPSLQAHVDYMTIAQEEAKASKKAAREAASDQSTNGGKSSNKQSLEIEELWKPAGGAISFWEACGISKSDYHSPPTLKQALDGYITSHNLLDPTNHKFILLDDELGRAVGIKKPEAGEKMARDEILNKLKNGVSWVVSIGGTIKKGALQPITMTVKSRGGRRTVTHVTGLELFNVDIESFAEDMRKRCAGSASIQPREGVSPKLGLQEVLVQGSQQKLITEALLERGVPKRWIKDERDKKGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C435</accession>
    <name>A0ABR3C435_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA polymerase</fullName>
            <ecNumber evidence="13">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_100192</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="13"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616665.1">
        <property type="nucleotide sequence ID" value="XM_066754764.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987050"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF42">
        <property type="entry name" value="DNA POLYMERASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="15">
        <location>
            <begin position="202"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0255388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="558" mass="64010" checksum="61F90FCEC2BAB5C5" modified="2025-10-08" version="1">MPSRPPIHPYTSSSTSTGVHGDQKATPHQLYKLFANLTFHIVAAKLEDDLPRIYECIDELGGKCMRPEDAWVIITALKGRQRLLRSLEEKWIETKQIVDVSYIRDTYQACLEHAVSPKTSTPKLPLRDDYLLHILPKGKFPIKSSRSTESGDANISQPSAKRRKVNDGYVATYRDDMTPLKEDVRLEDIPSSCAQRPCPLVCINQDIVNAIKPIFEEREFEEAQQKNSNVLSYRRSLSVTVPRRITSGKEALRLQGVGEKVASRIDEFLQTGEIAESQEILASPRYNALQTFASVYTIGHFRAKELYERHHCRTLEDVKRYFADMEKDGEAEQGRGKDRRRMRGGMKEYEIVEEWMKLKNELDQKIPREEVEEIAACVLENLEAFIPNCEYTICGGYRRGKTQSSDVDIVFRPPKDDQDIGLLRALYLRLSELRIVTHVLHVTHRDPNQPIRAAAQNFDNLDKAFVIFKLPGKGRLHRRVDLISAPRDRYASAVLSWTGSMMFERDLKRYAENETGHKFRAGLIKIATGEEINLETEREIFDYLGLRYIPPELRNGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C476</accession>
    <name>A0ABR3C476_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616710.1">
        <property type="nucleotide sequence ID" value="XM_066754809.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987095"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="100"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="308" mass="32858" checksum="1D628057C3525764" modified="2025-10-08" version="1">MQNKPEQDRNQEATVYLGNLDEKCTDALIWELMLQAGPVSNVFLPKDRISQAHQGFGFCEFMSEADAEYAVKIMNQIKLYGKPIRVNKASYDKKQVDVGANLFVGNLDPNVDEQTLYDTFSTFGTLADQPKIARDPTTGLSKGHAFIAYNDFEAADLAIENMNGQFFGGKQITAQYAFKKEGKGERHGSQAERLLAAQAKKRQLLPSTGGPALPYQGQYANALVANAVPAAPSGVPAYPPPPPPGMPVYQAPAPDAGYAGGYAGHSGAPAGYVPPPPAGFPVAQYQMPVGAPGQATPAPPPIRMGFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4D1</accession>
    <name>A0ABR3C4D1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616765.1">
        <property type="nucleotide sequence ID" value="XM_066754864.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987150"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="4">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="5">
        <location>
            <begin position="184"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0255488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="56064" checksum="1146C964E1751E71" modified="2025-10-08" version="1">MIPARPWSALSPIQALVEQTCDPTLPVPNDIANIELAELINRKKANSAREATTALLPHINSRNPNEALLALNVLDYLVKHCGYPIHLQISTKEFLNELVRRFPERPPMVIGRVMGKILDLIHEWKNTLCVTSKYKEDLVHIRDMHRLLSYKGYRFKQFDAARALASANPNENLKSPEELEQEDRAAKSAKLQELIRRGTPRDLAAAQELMKALAGAEPEKAVDYTAQTLKELDKVQAKAILLNDMLNNAAQGEKIGIEGDVYDQVAGACRGARPRIQKWIEDDNGEREGMMERLLLCNDLINTALERFEACKVGDWTKAQAVVERNNPNQKVADLISFDAAEDEPASSSFGGVTLPADNIPSTSNVGMTTAGLPLDLFAPSPVATPSPAGSSTTGAAGQKQMQDPMAFFNTVSPQPQAMQQGSQSASGFGGLGGLQQPTPNMNNNNFGFGGFQASQSSSPAVGYSVSPKPAALSSQQFIQPQQPQQPQQSQQSQPQQQQQTKKDAFADLVDLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4X5</accession>
    <name>A0ABR3C4X5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616951.1">
        <property type="nucleotide sequence ID" value="XM_066755050.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987339"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="168" mass="19116" checksum="F48CF9C823DE7783" modified="2025-10-08" version="1">MPTRPGDLPTGRLDAGSRWLRESFIMGRVRTKTVKRSSRILIERYYPRLTLDFHSNKRILDEVATVPSKRLRNKIAGFTTHLMKRIQKGPVRGISFRLQEEERERKDQYVPEVSALAASEESPLEVDAETKDLLKSLGMDDLSVNVINVTANAPRERKSRFVPGAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C592</accession>
    <name>A0ABR3C592_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617070.1">
        <property type="nucleotide sequence ID" value="XM_066755169.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987460"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.60">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="8">
        <location>
            <begin position="835"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="208"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="385"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="531"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="618"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="886" mass="98672" checksum="B9F2D5269CD7B550" modified="2025-10-08" version="1">MFAVSLQDRLKAAVNSLEATGSSLQARALNANQHPHDTKDSGPQDATNANPPPAPPSPTFQHSSSSKQDVRPQSVPVYLNQAAYTGATTSQLAENALSGLRKSLQFGRSSLDLPNSVGISSSLPATPNGQEVKDISLPSLSASVPAEPSAFAGKSPTASSLEISDATDGPTEIHARSIPLRALTDPISIPLPPSPTLSSISCSLEADPLGASTSDDGVDETTIPRTASPSKNDHKELDIVEKPSTNEDGKDLGQPDEEVVSTDVKKLADLGRRYDDLSNRFTNLLTQTHQANKIFRELTRLESGISDAEALEGWVRMMVGKVEMMGKEMKRLQDNLTLQDSRIEELRDTHRLESASQNELVSKLRSDLSESESKLSTYSSTVATLTQVRSDLAKSLTQVKEEEEKRTKAISLLKTVRLKLVKVEKEKEELEKDRASERAERSRLTEEMEKARIEKEKEVSSLKKGFERELAGAKERYEKDLKDKKASWELEMITTKAAHAKELSQKSTKISGLEAIIKELNTNKQTIHALLQSKQAEAESARAEMEEMQTKSKELEFQLREANERCSLLEDSMRDDVVRRGQSVGLTETGTDSLSPNRNSSLSGAGPMEIQRLLAESESRAESKLSDLRARIRSLECERNELEEEWAGKMQERVKELEKMRRVLLDKEKEHARSLEGLRERESRIQEVEQKTRDLEAEISRMKLRMEEVEGDKAVAAESERTAREELSSLQHELVDLHSQLDDSKSHISFLKSTNKTLRDEMRKIQSSIQLMEKQRNPGVGYWAAAGGQRSNMVSPPMSNVNLDSPAPGRKSAESIRTATGTEIGSELGESKRTPEEEDLNLEYLRNVILQFLEHKEMRPNLVRVMSVILRFTPQELRRLNAKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C593</accession>
    <name>A0ABR3C593_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617059.1">
        <property type="nucleotide sequence ID" value="XM_066755158.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987447"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046106148" description="CCHC-type domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="228" mass="24167" checksum="C355B55FA38AB21D" modified="2025-10-08" version="1">MLKPVAFLLLGGVATCTCWWRRRPPPPPPGGIIVCLTGRSKTKTMFGAAAVPGSRQGCFKCGNLGHIAENCQAPGRLCYNCREPGHESTNCPQPRSTDGKQCYACGGVGHVKSDCPSMRGAFGPGQKCFKCGRPGHLARECTVPGFVGAFRGRGGFGGAFGGRPRPPVNPDGTPVKCYRCNGENHLARDCLAPRDEAAILASKKCYKCQETGHIARDCTKEDVSPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5N6</accession>
    <name>A0ABR3C5N6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5745 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616757.1">
        <property type="nucleotide sequence ID" value="XM_066754856.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987142"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044039">
        <property type="entry name" value="DUF5745"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19016">
        <property type="entry name" value="DUF5745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5745" evidence="2">
        <location>
            <begin position="48"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="281" mass="30375" checksum="67E580685E21C4CE" modified="2025-10-08" version="1">MPTPPLPLFHQLLTALRIPITPPSLAAIPPSLLLLTLEIILNTRLSLPHSTRLCQTSDDELVVIKCVLGVLADDILGMDLSVVDPMNVVRGGEHEMAVMIMALVVAARRRGIHVTLPPPAKAVGNGRRCSSKMGVEKVSSWLDDDDDDEEDWENSTLLRSALPPPILPDVSLSSETSVLDTSAGTSFTMEQPDDEFSYLKVSPDKRGYERTQGGFMTPVMNSTGVSRGRPPSPSRHMITPTPGPRENFSAQSPSLRSSVEQGSGRTVLQYMLDELGLSLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5T9</accession>
    <name>A0ABR3C5T9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100791</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617257.1">
        <property type="nucleotide sequence ID" value="XM_066755356.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987649"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF10">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="796" mass="85116" checksum="DB38301F2E3E1383" modified="2025-10-08" version="1">MDGAIGHDRTILGLYDESPAIILHLGSFIVSHTSLFISFVLLFIAYSTPIYILTTANTDTDTHHTPSHNSSLATELLSTSLVHPVSIGLHLIYIVNHPQATLSTMATMNSPSVAFSQGDIDMTTHNDIANFEELFNFEEFVSAGESSTHGNSPATESNATPSPLPTQDPLFHSTSFDFFDTSMDTDFPIGLSLGDSTESKPAFTNEIVVKQEPVDYPVFDTQSSAPTPAHTQSAALSFGGLPVDQQAALQQLMENIINYQKKFGAELPGMAASPAEGNAQTIEPSMLFTNSPASDSAAAPTQPMAVAPVAHSAPATTSNTPALAVAPSPVPVPFAAPVPSTTQSCEKSEEPLRSISEEPNRTRGVSTISFEDLDSRIERLVPLPEIFSAGKGKGGKKGGGMSSVVREEGEDLDDDESWRPSPEEYKKLSSKEKRQLRNKLSARAFRTRRKDYIGTLEAHIKDRDMVIDEMRNELVSSRNENQDLKKELAALKASTMSILHPESASKSFSPALVSALAKSPAITSAGSSATPNGPVRRPGTPLNTYNPRKDLPSSLKGGWGNDNMFGGGSTICHTIMTPDLVLPSSNPAPLRSLADLPRVNLNPHLYEPGPSTLPHTLSNPASGADGSSTFSEWSENTPWSLRSMDSYRMQIWSRLAKEAAADKANLAGDLRPKFFVEGPSTLTPSATDVAGAATSHITSKLAASFWSAFTQGSSKSLDTDKLAAVVTGQAKLKVVPVIQKEDEEDVLATLMGGLKMQSGVSPCERRRAEGARENPLVSSGVKSLTGFPSAFHHIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5Y7</accession>
    <name>A0ABR3C5Y7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617314.1">
        <property type="nucleotide sequence ID" value="XM_066755413.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987707"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="5">
        <location>
            <begin position="57"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="6">
        <location>
            <begin position="947"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="651"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0256037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1006" mass="110078" checksum="43E6BE9E8C7FFF11" modified="2025-10-08" version="1">MSEGERPTFDIAVPAKDPEPKEDDKPKHAGDKGKARDDGKDEGPEMSEEDLQLKAELEMLVQRLRESDSGLYQPALESLRTLIRTSTSSMTSVPKPLKFLRPFYEEMGKIRDGWSESLKEQRSLLASILSVLAMTYSDTGKRETLYYRVLSGSEEAPGLWGHEYVRHLAAELGEEYAATYAALGEDTDIPQPDTKYTTHQLRALSIELVEFFLKHNAEADAVDILLEVENISAITNYVDDKTFERVCRYMVSCVPLLVNPDDNAFLETASIIYSKYDRYPEALALAVRLNNPELIRKYYEAPTNPVMKKQLSYFLARAQIPLHWVHTAEDAEPNDAIPTQTDDVLECLGNVKLSTHFRNFGKAVGVEEAKSIDDIYKTHLEPSSRNTVIPDSARQNLASTFVNAFVNAGFGNDKLMINAPEGQSWIYKNKAEGMMSATASVGLSLLWDSESGIDHIDKYSYSAEEHIKAGAFLATGIVHSGIRSDPDIAFALLEEHVDSQSVPLKISAINGIAIAYAGSERQDIADKLLPYVQDESTSMEVSSMAILALGFVFVGSSNGDIASEILQTLMEREESQLASEWTVFACLGLGLLYLSAQEESEPTLATLKAIEHPIAEIAQTIVSICANAGTGNVLKIQEMLYICSEHAAEKKDEKKEETAAEGEGESPVAVSEVPGAIPAAGPPVPPTAAGVPGTDIEGDVDMSEVAAEAGASDGKAQPTATGEQGEKEKEIEKEVKTAEQLKHQAFATLGIALIAMGEEVGAEMALRQFQHLMTYGDPVIRKSVPLALGLISASNPQLSILDTLSKYSHDSDLEVAINAILAMGFVGAGTNNARLAQMLRGLAVYYAKEADCLFMVRIAQGLVHMGKGTIGINPFYNDRQVMSKTAVAGLLSVLVSFTDARKFVLSKYHWMLYWIVPAMFPQFLITLNEELEEIPVTVRVGQAVNTVAQAGTRHGISGFQTHQSPVRIATTERAELGTNEFFPYQSVLEGLVILKKNEQYNAEDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI40</accession>
    <name>A0ABR3BI40_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610865.1">
        <property type="nucleotide sequence ID" value="XM_066761040.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993472"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="686" mass="76468" checksum="4F36325D9B241081" modified="2025-10-08" version="1">MPTRLNQPAALAPTRILEPKRHSSDKSFSATKARIRQRISQLSINKNKVHNESQRRNTGEHQEKEEEEFHYLHVNAVMPSEAYVWEKNVARKPSRSFDSKDAHKLKVIASLPSISTSPSTFSFPEQPLRESISKSIDLCFNEAKTDSFISTSTMDNPPPTPPPKITIQSDEQATPKATQVAFSRATVARKAPSVNSFTGNGSFLGLPEEADMFYRSNAVWGDLDISQDQQASHKKCVATQHLSPPSANQQKRLKVADLQFADADLEAGRTNGKGSCDLNDTMEKSEPLDKPLPHLPDSNGSSEYSISTYSQWSAVILKATRSPDVSRSPDSRPLPQWKSSTPRRSRRPLASTNFCDELVEDGDEQGATVANQTTHSSSEREQPRQEVHVERESTRTRHGRSGSVSSRATANAIQQGYRPAGSTLTRNLIHKISPQEASRSVIDHSIASAKPIMNTMTKRINSGKGSESTKRSFELDDNAAVRPKATQDQAIDSLVEDDDVEIIGDLTFTSSRPPSVSSSINTMKATSFASVTATHASRLFARSQYPHNTSSQGSRTYPPVRVRSQLEDSVPHCPLGISIIFPQSKRVPTRKGHKSIFDPFSSFDPHVPIVPCKTVPNDNWILITNTAEDDILRNGWKDVEMRWMEGESFREWMMRRIRGEPWNTVVLREKRADEQLRMMELSDGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIE0</accession>
    <name>A0ABR3BIE0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610916.1">
        <property type="nucleotide sequence ID" value="XM_066761091.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993524"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="335" mass="38606" checksum="438DAE9AABFC2133" modified="2025-10-08" version="1">MPTRKSPNQISGDAPSVNLSSSLFARLLPVQHLIFEQLALINPLTTLRICHFSYRITIPILYRDVTASYGLFRGLKQQTEDYQRTVKALSFTRVLRLENFISMDAVYHLTFDVEDPDPETEDKYPRPYQNLFPKVEKIVYNWPAIQSDYHEYIDVLESSLLDFVVGRGSRLRSQLGERFREVEVHLENGRIDYWLEIEQFMFFNGPKDVVIHIDVHNPTILASIGDFMPLAWANAEKLRVIIRSEGPASNGSSSKEKYVEPLAESLAKYASRLTQGDNPTDESEAGPFQRPKKVFFTFPDQREVLEELFELVIGEKEDEEAAVLKEVIKEHTVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIF1</accession>
    <name>A0ABR3BIF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lactam utilization protein lamB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_106264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610969.1">
        <property type="nucleotide sequence ID" value="XM_066760697.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993119"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003816">
        <property type="entry name" value="PRK05406.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292:SF0">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBGL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0240470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28047" checksum="2520166781C65B1E" modified="2025-10-08" version="1">MTSVAAVFPRVSINCDMGEGFAKWKLGPDEELMPLIDFANIACGFHAGDQNTMLRTVRSAIKHNVKIGAHPGLDDIKGFGRRAFAVSEEEVYALALYQIGALKAIVEAEGGKLSHVKVHGALYFILRDHPSLLRSFLKAQISFSPDSPLPFVGLADTPHEEISKEMGVPFVPELFCDIDYDKSGKLLSVPESRAPTEALIRDRLARVLTKGETLDNDNNPLKLPVLGRSFTICLHSDMPTALANVMAARQIVDEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJC6</accession>
    <name>A0ABR3BJC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_106079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611287.1">
        <property type="nucleotide sequence ID" value="XM_066760526.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992934"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="386"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0241905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="822" mass="89786" checksum="B541340C39727E7C" modified="2025-10-08" version="1">MITMPKRKLSLDRSQSPDPLSMSVHGSDDDGDTSLEEQIIVKSPPPRKHAIKPTPTRLQAVVEIDVPVHRLRSGAVVSSPSRKTPVKTPVKTSAKTPVTTKKIRMASDVPSPTPNGKGKGKGETVPESGAGLTSSSLKVAINPTRSCRKPRTPARTPATKASASASKALANNTPTLASSISKPLPTPSPALLVSSARKRPRLDKFAAKTLDFDNGIFSDPDDELEQGKSGVVVSTEVFRANERLKKQREARNFTYEGEANAPRMMRSGRALAEVNKDQGDEDENMDEYGPRLEEENPLAPQAPVIPDIAVQQLLITPSEPLLPSTQAPSSPCIIIPAFQKTYLHAMLNTLTSQNISINPPPFDDEEHNETLHGVLNLMKGTVERGEGNSAIVVGPRGSGKTRTVARALNLLPCSSSTSPIIVRLSGHAQTNDKLAIREMGRQIAEVEGRKYGGEGTGEEGEDVDDDDDEGYAPTTLPSHLLALLTAPSPRAIIIILEEFDLFTEHARQALLYCLFDVVQSVKTGLTESTPRGIAVLGLTTRVDTLLLLEKRVKSRFSHRIWRVASPLASAPASNKVNGTSGTDGMDGVKEEAGWKRLVQRALVLWKTEEGEVDDEVGKWKGDWEYSVDEILRTPTIERNFDRLASLTTDVRNVYRPFIEPLIEVINGKTEYLQLDKILNNVVSQVESAGWGLQSSKLRGLPHPALGILIIAKHLAYAGREEFNFAQVEEEYMRFSRTRLVGSGKVRWPIGVLKRSFDYLQNISLLIPTTSTSSTSLNRQQPQFARVRCALAPNEIVAWFKGEGKDVLGVEMGNWGRMVGGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJF9</accession>
    <name>A0ABR3BJF9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611312.1">
        <property type="nucleotide sequence ID" value="XM_066760551.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992959"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0241930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1017" mass="111386" checksum="4DD1ED53ECAE6339" modified="2025-10-08" version="1">MFPFGKKGIAVPKAREDRDAIQYANYSARKVANHGPPLLRTYAGGKGGHDNTAGAENKSISTLEDANERGRFFTTSAGLWQRSSMGSPALTSSKGGGSEWFETSAVQYNQPSPGYESQATLFKKRIPTGPAAMVSQDPRAIQPQLSTHAERPKDPRLTAPADVAPDVALNPVETPQKSVDPRIYKTNPCQPSQPIQPPRDLRHPPSGQIMPSPERELNRATPSLPMEGAQRVPLCSGIPSNPSMVPSAMKDNSALASIPASRISEEESRIATSAGNNNGHLNLLETAAKGGGAQTAMDASKDSAPAAEIVDVKPTLEELEIATGAAVPQVRDEDRLEGCVSFTRSELPTGFWSKDAAERRDLRNKLRAEQEKELEKMGRKLVKGHWRDDGVAFDWVLSRKNAGGSGTVKDNEVREVAEVVDASSPRTGERQDQLEEERFIPLETQTTPLSFLEPSDISGPAQNTVTGPVASGVSSPQPSSAPQMQQPSQESQSGEKIASSSAIAPPPAPAKYSKAETKWGPPIIGKPPVRGRINRIYKYDIPVPKSMKVGDRFAPEFQAWKLRHRDEACCFDTRGCPTREAFLNHNSAATCDHLSMKIVPIDMSNPDSWPVSMFPDQVSVPIPASITPGEEFDAWSAIICDRISEPDWRGRPTRWVRPLHIPSSTGQFKIKLRTKTREEIESYNGPAIFLSQASPLELSPKAADKVDNPLSSSFATPKAGASGKLNQSLSEQQKKRISNMLEAEAAEVAKKKRRTSESYFEREWDREKRPGSPVFKEERSSKMQKKDTGLDKSRGREKEKEQEREQEKGKAIEAEREWQRGRALESNGERGQSSPHYSKFRTVVSNRTLDVAGARSESVVSSSANIPALPQAVQRADPESSSARLEVEGMVTELPTAESTHSFPAHSTASPFTGRHYRAPDLMPAPSAASHLAKSHTSSPIPSAPLSATGSVPVISSHLQELRKKIRQKMAEITKWTLLLEDFPDMADTMNVQIQRTQDEIFGLHDDIRKEEAKLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJQ8</accession>
    <name>A0ABR3BJQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611407.1">
        <property type="nucleotide sequence ID" value="XM_066760646.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993054"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="275" mass="30267" checksum="9C75268A68B3D8EA" modified="2025-10-08" version="1">MARTLRNDDVVRESGDYHAIYSKWLTDSLATYPDTAVAQRTHLVVDPYDVVDKKEYPPLERLQYGAPDAYDCVMLTGSKHTAYDTANPFIPPLIQFVRSLASSPTYQHLKLIGICFGHQIISIALGGACVQGENGWEIGVYGCHLTDQGRYWWTGDVKGQGGAHKHKDHVPSLPPGCTLLLSTPRYPIHSFFKPHPESTPSHPLAQILTIQGHPEFTPSIVNHVVNARDAAGVFDQATTKEARRRAGGKHGTGGEGFGRIGWAVWRVLLQDLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJU7</accession>
    <name>A0ABR3BJU7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611452.1">
        <property type="nucleotide sequence ID" value="XM_066760691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993113"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF61">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0242070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="122" mass="13114" checksum="97F73547D062EBB4" modified="2025-10-08" version="1">MATVMYLTDAYEKYASSALSAASLGRNTFAAFLPLASQNLFNNLGFHWAGSLLGFLALVLSGVPILLFFKGRYLRSKSPFIAEATFDQGDSEERHKTNKVEKNKGLGGPAGQAKPTAPTIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJW4</accession>
    <name>A0ABR3BJW4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611466.1">
        <property type="nucleotide sequence ID" value="XM_066760162.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992567"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="303" mass="34665" checksum="A720CBA3A67EEFE7" modified="2025-10-08" version="1">MVPDKCLKAGWPATVKRKGWKPFRSVYEVEHNVKVVSLQYICTEHGVYSPSADNYWEERSRNEGVLIVENILQLHILHSRRLETWFYAAALHERTRMSFFNKSAEPFPMMLPRAQIDKDDEPFAISINRVLSLTPYEHATNTLWQGSVNMEARSTFPLCRVANKASVQRIGFLGIFPNNSSSFRAALASSHHVFVMNNLLRQREALYGVPQPLLLNVAPHHRFGLVPRQPPGEFNGDPEKRYKFLKENLRTIHEKHGGGEEEDKDGIGGVRPLINSLSPQKVSPYCIISHVEEGQANRQKEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJZ2</accession>
    <name>A0ABR3BJZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105738</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611492.1">
        <property type="nucleotide sequence ID" value="XM_066760188.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992593"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="382"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0242110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="845" mass="92612" checksum="0D50FA5340C8751F" modified="2025-10-08" version="1">MQPPTTPTSNRRSHFPSSCRSFSAGPATAPRRSGYQSRPNSFLRLFIGALAISASKTWVVDSHGGEGGGAGWLVLAYWASRLFVEGKRVWDGRRRKGSRLDATSTGIGVKDYIFSSFSYVLQSLAFFMSLGSLGPFRTSIIGLTGSLLATSQLTTIRSFGLLLPLILASGYALTQQIMSKNLQAVSTSLVFASTTFVVQGRFFEPKAAGGRETVNGRHSLYRIIVPSFLATVSVIALYLMDFIPIPFPVSSTTSQCFGSFGAAFLVSNIPLSFCQKSPSSAGLLLKTWRDKVTFLISIPILQFFALHPIPTTVDVVVLLPLSVFSIWAVSVANAQAEVAPLWTFSSHNLTTAKHSWSFLSLVPAGWRPHLQTIISTPTSSRIFYFLLLNLAYMGVQMVYGVFTNSLGLISDAIHMLFDCLGLAVGLWASVAAMWKPDGRYTFGYSRVETLSGFANGCFLILISVFIIFEAIQRVYNPPEMETHQLLLVSGIGLAINLWGMWATGGHHHHGHSHGHDHRHIHAAPKMEMPKQGVHKDDGAHRHEDHGHHHKSSASSQVSPRPASKLQKRRSTGHLKDSGPRPITPHKASNGHNHAHEHEHNHDEHCSHEHEDHSHPHDHRHHKSTDNLATHNHVHSHEDEYDHAHAHGHGHDHDHGHDHAHSHNMRGVFLHVLADTLGSVGVIISTILIRFTGWTGFDPIASLFIAALIMASVIPLVIDSGRILCLDVGQAKESEIRSALTELSSVDGLASYAAPRFWPRCEGEIVGSIHIQLAPSSSSFDPTRLSTPPNSTRPRKGDAFYANSAKVVGRVEKVLKKRIKGLTELVVQVEGSEERSFCTCMTGGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKE0</accession>
    <name>A0ABR3BKE0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611263.1">
        <property type="nucleotide sequence ID" value="XM_066760502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992910"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047484935" evidence="1">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0241881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="115" mass="12458" checksum="BD11D210CF40EDCD" modified="2025-10-08" version="1">MLRFASIIFMLGMLFTSGRAVWLFNQASSNPTGSSLSVLSAETTRSCLLPGEVLTLYASRTFDSRPFLDGNLFARAKAASQIIAKGPYTPSHSFLTIPKASYALPWTFGSTQLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKZ6</accession>
    <name>A0ABR3BKZ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610920.1">
        <property type="nucleotide sequence ID" value="XM_066761095.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993528"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="426" mass="50187" checksum="B9C6FF67661DB02A" modified="2025-10-08" version="1">MGEYDVRPSKIKLKETKADRAEKIYRREQRRYRKEQERISRANGYAVSPPRPYREESISPPRKQPKQRPRGFEEEEDCEAGWMGGYGRRAREEVEKREWDDKMRWMANEASDPFGDWPTFGRAGPSFSHIPERWRPSSPSIPRPPGFGPFPFPPFHNHHIHSTHQAHPIHHTHSTHHTHSARRNPLDEVDPYGIPIPSLGHMTDNEYTNFVREGMYARRRAEEMFAAERHRREREAREREREIEREKRERKEEKRRHRREREEYERRRARSSESSSPIPISHPHTAPHSTLDDPAKYFTRWDSLQTGGEVESTELRFDDIPWPVFRPSARGGSSGLRESILLDTITLENVRKFMMAVANHSSHLNSSSAGGIMGNLRKTVRETIRNFHPDRFDSRVLKRVRQKDREKVKQGADLVSRVLNDLVRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLP4</accession>
    <name>A0ABR3BLP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611911.1">
        <property type="nucleotide sequence ID" value="XM_066759965.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992365"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF45">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="319" mass="35268" checksum="0B0B7EBBA0EBE0AD" modified="2025-10-08" version="1">MSLGSEFDGSKGWKSLEERGISTEALEGLTIESRECLERLTNSDSHSVHDFGIVKRAAVLVVLFQREADEKLHVLLTTRAKTLRRHPSQTALPGGKVDPDDRDATHTARREAFEEVNLPLEHPSIHNLTVLEPVMTILPLNAHMKNHITVIPVVCFLSDVSLLEHLRPSPDEVDAIFTHPLKGCLTGMVEGKDLEGLAEKGSEWWPYEEEFHSIEDRIGTTGGYRMHRFRTKKTPIKGLTSDVLVHAASVAYGSPPAFGRFAPNQPPFSSAISNVVLELPGVIDQSITASVPGEPPRVLEWGGTEKGTRIISQEHYELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLV3</accession>
    <name>A0ABR3BLV3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612143.1">
        <property type="nucleotide sequence ID" value="XM_066759496.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991893"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="602" mass="63930" checksum="51C20A32819B637B" modified="2025-10-08" version="1">MTMSSPSGSPRSSVSSATTNVCGAPLTPVYELDGAAGEMVVRDSSTVDDSESEPDILHEHIAVEQAPKRINLSLAVPPPTFSAFTFPTQITAANGVPLSEEGIALPREGFSFGTCPSVPFLGTPVAEQGPFEYPDMTGSRSTSRPSSIKGSSQSRSNSRSPHFHGRPLSISSQQSLGSQSDIPSPPGTRRESTVSDIATIPVAARRPSIVHPATIETSVPNSTFASSSNTSPTPSVTHLPSPAPLSHHGSIRRPSTLSFQQKALPAPIPPSLLARRGSLPAAQLFGLPLSELSTTHRSRPSANSIPPLPQSPALTTASLYQRRQSIATETGGVVHPRGTLPEKVRTSSISAGSDSTGYTSSDRRGSLPYIHPAHSLPSSRNAVLSRSGSTSSQTSRRSFKSSSRTPPTNHSSTIPSSPQNQPASLLPPLSVPPSPAFTRSSSADAVPEQTRSDHHYSRKSKSRSSSDEDDELPTPAVDSLSISRSVVGGPGMNTDMVSAGGGASEDEVVYLGGPGSSQVLVESPTAMRDERICKKPLPPSSWPVQWCGWREEIDRRWQRLNETAGIFNPIYVAEPIRTRAYRLSKRTYNCCSKRSQDPTISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM79</accession>
    <name>A0ABR3BM79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611370.1">
        <property type="nucleotide sequence ID" value="XM_066760609.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993017"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0241988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="286" mass="31773" checksum="AB92F290C7CA9F1E" modified="2025-10-08" version="1">MRLTVRDTKEQVGNYIGNYIANRINSFVPTSEHKNFVLGLPTGSSPLPVYKRLVELYNEKKVSFKDVVTFNMDEYVGIPRDHPESYHTFMFKNFFSLIDISPNNTHILNGEAEDLYQECEEYEASIKAVGGIDLFLGGIGADGHIAFNEPGSSLTSRTRIKTLAYETILDNCRFFNNDLSLVPRMALTVGVQTVMDAKEVVLVVTGQNKSLALSQMIEGGVNHMVTASALQTHPWALVVCDEDATLELRVKTVKYFKSIEKVQDEVEAKYGPVASVRLGLRGPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMN4</accession>
    <name>A0ABR3BMN4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612411.1">
        <property type="nucleotide sequence ID" value="XM_066759764.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992163"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="526"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0244044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="558" mass="61336" checksum="0A4B287540E337E4" modified="2025-10-08" version="1">MGSEKYQIQRKIVDLDTGVRSNNLLAEKPQQGEVNETSSMAPQVQPPYPPSPFVPLSESHAQSAFENPSASPDEIDYFTETRKFRLRHAMEEDGCGMMSSSAPPTLLTKITGEVWKELRPIMDIGTGFLMLDAQSQTSVQVRESQGIYNRDKYEYYAAPAIDLETGYRYDRLLRAKLEKASSSDQSTPPPEHSTHFGHTGLGGWTTPHHTLMPFPPPDQLTDLQQTSIYPPLPRSTVSPPVPPLKEQRAVIEWQPSLLPLPAVPLPSLHASLDVSVAALYRPASIFGPFAGELPAAPQPVTHHPPQTELCVAQVPSQELIRQTTCVNMQLHGCSQTHIHPDLVAPLPPNAIFLRRVVSTQGGTQGFYGLSAHENKDGQYVSVSATNDGDHLPPNYPHGSYLSPSPDHVPPSIMTNHRHSLSVPGQGQNDAPPVLKVHVHQTEGMPLIGVGMLYPTPPNPNNPVEEGFASLPPLPKKKRGSPRPSAYPNYLVEKSNGEDRQGKRPGECIGQEGFQFGRRFLPKTAITCNFCRLKKLKCNGQSPACSHCKRQCNSECVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMU3</accession>
    <name>A0ABR3BMU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612462.1">
        <property type="nucleotide sequence ID" value="XM_066758975.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991357"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0245378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="94" mass="10706" checksum="E5FC753FF8664481" modified="2025-10-08" version="1">MKQIHPKLARRVPGLILYRQNLLCQSPGPESSVDSEFDACSEYTYVSEEAYTKAKGTEEWKALDRDSKEFIRDRGHIDSFSVQSSVSWLPVPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMU9</accession>
    <name>A0ABR3BMU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Asteroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611949.1">
        <property type="nucleotide sequence ID" value="XM_066760003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992404"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="809"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="857" mass="95249" checksum="F2A8886BD5B98564" modified="2025-10-08" version="1">MGVRGLQTFVRENRGSLCRSVLLPERDPQGSHRGNIPLIVDAWGVIFKLYLDSLPWASGGEYLRFYQITKQLVTAWRKVGLEPTFVFDGAAPIEKHPTILKRMTEALSTPKLFYATSVASRSEPSFGRGCSIKPLLPPFASHAFIFALHRLGAATHHVPSGEADGACVTMAERIGGYVLGQDTDFLILVGKSEGVAGYVPLDMLNWIEGEVSEEEAQDDKLGQSPTKTFRPAYGRRKKSHTPWQSSLLPPPNYHHPTLVMTVIPPQTLRQRLRLPANYMALFASLVGNDYTPPEALERFYEPSLGVCQRIEKAARVLREQLFSPSANNRRNVNPGDFVVELVSRVVKKLCIWQYDTEPDLLRAVNGIIEAALQYTSPHGGECCSTYPFCGELDPLGCQTPYNRPNIPGSSMSSEDNHSQSHKALEAYAAAQRKGSLLFITHGWLYPNRIYLRGTLEDPTMASPRTWEGSRGLRLASYVIAEEGLGGFRFVDEPLPGVKNGTTPAEEQEDRELRGLLGVELSTESSETSLTSQDAQSVDRSEVTDDPPRVMVEYVRQGSAGKVVPYTLDLPPRKDSSGSIPVCLRTLPDRLQAYLGPMQSDTPAIRLLPSSLQPLVAMIRHCVIEMARLTEKNERATNPAWRRHEAYAVLRAGVGTFAQWRRELDSEEMVGLKRKKLAPISHEDQAKEWPTLERRHAHLIAQLGNAMMDSTSLSESLLLLSTQIPYFTPIQMESLPQPLIGDPIADFGPTHLTPFVFFSGINIHSLLNHEEPPSHLKWRWTPEEDKTLHMCWSALIDDLEDGLMLGLNSSGANDAESLTQTTNTAGSENARRSKKRVAKKQSQGKARGMFDLLGDMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN79</accession>
    <name>A0ABR3BN79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_104659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612611.1">
        <property type="nucleotide sequence ID" value="XM_066759124.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991515"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0245527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="583" mass="62338" checksum="BD4D62A90A2E0B00" modified="2025-10-08" version="1">MTLSERERLLKPAPAPPGTTLYSEPDHSKDIKTTDEHKLSYNKVGLSARRFWILCASMWVASFLNAFDGTVVATLLGPISSSFKATNMASWLGTAYMLSVCCFTPIYGRLCDIIGRQGSMLLALAIFTTGNLLCAIAPSMEALIAARALAGMGGGGLSTVGSTIMSDIVPITHRGIFQGLANLAFGGGMGLGAPIGGIINDSLSWRWAFWAQIPVLLFASYLIHSNVRYDVPSRPSSGAATPNPAAAGMQTAMQLFKRIDFLGCFLLAGWVGAALIAVSLNINSTATNAHNWSDPIMIALFITSAVFFVLFLLVELKWAAEPVMPFELLVSRTPVAVAINNFVLSVVNFAILYSVPLYFTAVRQMSASNAGAHLIPNSFVGMIGSLGTGLVVRRSHKYYWLNTFCACFGVIGCFLISTWNLGTSEWMLWTNMSFTSFAMGAVTTLTIVALIADVGPEHVAIATSLSYVFRTIGQVLGVALSGALTQAVLTGELKKRIQGPNAEEIIASIRESSASIQYLPEPLKSTAIASYQKGLHAVFICTVVLSVITLLSGLGIREVDMKLILSGGKPTLLDQNESEEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BN86</accession>
    <name>A0ABR3BN86_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612606.1">
        <property type="nucleotide sequence ID" value="XM_066759119.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991510"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0245522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="604" mass="66933" checksum="FBB21A20C9D34DD5" modified="2025-10-08" version="1">MSRTQDPDLTYWRDKVERLAALCSRLQRPRQSTSETEIIDILDGLAVALRDESLRTPIGSLGLPDTLTELLEQAITVDWEEVVKQVGRVAANLAVENDFNRELLAESGFIDLVLSPSLLDRNSSHPSDHALVASLYNLVVQGNKNNLRCLCRLAVNHLQQVHESKAVCSMDLTITQWLWSILNAIINNSDNNEGKILNQLPLLDLFNHFRYWIPPEPLSDFVVDSGPESPLNILFSSCQVIGHIFSEHSDILKQLMEDDATLPKAAKHALELILDFVELADLPLSWTSASTDQRDNGEDTSEEEDFDAKKVLGEAKACLINGVVAFSSGLTLGTLPLGFWTRMRSWLDNDVSDRRDLMECALLVYGNSITGDTVAIEYLVGETTLLPRIKYLLKPDVAATTQHAVVGLLRNLSIPDQNKSVLYEGGVVDDLMQMGVWSENRDMLGSVQGGVVGIFKNLCRNQPDIASSLMTSYKEDLISLCERTNDQAIKFEGTRVFVNAARNLPKGMNSQGVNALCDERIVKLLVDMLSNASQYPVLEDEAVLGLAFLSIFSPAKALVIKELTAEREGGTGKTRLEQMVANNDLLKEGRENAEALLSLMRDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNA6</accession>
    <name>A0ABR3BNA6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612638.1">
        <property type="nucleotide sequence ID" value="XM_066759151.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991542"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="371" mass="42851" checksum="A24AE06455BFBD2D" modified="2025-10-08" version="1">MLLPPRLPRPSLPRAKVYRLFLQHLRFLPDPQVWTTTVPRFRKLLETPGPSPSGSNPADNDGARKVNEIREWRREKAMKKAHKEFNKLRAAVACHPHALARLLEESYGQRGNLRWQRLQEISAPYGSILSQDPLPPPLMPLRPPPPPPDESQPRARKRMPACRLRKQAQRLVQRDWNGVQPPIYLPPSSETKGDVDKKERTMVNNLRILAGLSEEPASPLTSGTALDLSPLSSNLSRFFPTNPRRIRSLPLPPYPPPRPKHTRSNPHTWSLPRKLCGRLVRRTYKRLWDKLVWVRPVEGDKWKKCGYRELQDWEQGLIEESLVKIPDSNKGKKSKKERAIERMPKNIDSSKWSCATPEDRQWLSFGKMQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP23</accession>
    <name>A0ABR3BP23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612917.1">
        <property type="nucleotide sequence ID" value="XM_066759430.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991825"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="800"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="542"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="607"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="756"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1095"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="316"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1101"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="829"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1121" mass="127240" checksum="0E1902C602024272" modified="2025-10-08" version="1">MSGRPFKRESWRPAKRHPTFPAASQQPPLSGVNALPARAWGGVPVPTAPKRFEREVKEEAHLSRWDDKGSSSGKWDQRDWDQRDDRWRYGHSSNGKRRQSPSRQPAPTRDERFSSSRRSYSPLAHAPSPADPSNYPATRRPLQAAQSPASHHRTPARVRRLSSDYDTSGPAAKKRKNGVKGRESPDYGVGSREDMASTYRRSPSPLSIRSHSRTPSRSRSPAPSHHSQSRSYSHSQTQTHTYTPPQSYRKRSLSPAMSDRQSSSGKWAKHSRYNIHKYDKYDKDDRNGNEDRNGKFDSRDNGWEEERDRNWRHRGTNRDGHRRDRGAGDREGRQVKDWEQDKEYGYDRRDRERDRDRRRDRDRDRDSGWQASRRDRDYPPTGSRGSTSSASQLRRDYEAAPSSQRPVHVQSPPPPGDFYDRPRDSSGSYSRQNHGYGQRKGRSPMQDREYAPRSNFVTNTNANAIVGTSTPRKWGESGRYPYEQSYQPPSTVSRATSVSRDYPPSPQHSHAPPAATSDTVPDLACPPASAYPSLPMSFAEYIPRTDDSLSDLPPQLEFSLQPLPDTPRPSAELQIRTSPVKISFGQPSVKTVKKGWKSISPKQKARVSLFDEDEEDIQGTKGEKEARKETVPEKEQGTMGEALPHPDTLIHRLTLASTRYTTLLTSLSAPLRAAFDSFSTLPSSPPPPPIDLFLDEYLGRKARDDEVKRVEEVWEAKKEWEREEEMGRRYLEEVGKGGRVEGVNAVPAERGVVRTSPAVIAAPKPEPELEPEPQAPASGAESQPQSQVAIPLPAARTSVYQKLAPVGEGTYGKVYKALSLITHQPVALKRIRMENEKDGFPVTAMREIKLLQMLQHENVLRLMEMVVERGGVYMVLEYMEFDLTGLLAHPEIKFSPANIKSLSHQMLSGLSYLHHRSILHRDMKGSNILVNSRGELKLADFGLARVYAKKRREDYTNRVITLWYRSPELLMGETIYGPEVDMWSAGCIILELYTTKPIFQGSDELNQLEVIYALLGTPTEAEWPSVKELPWYELVKPKEEIGSKFRTSFAKWLSPAALDLVEGLLFYDPSQRLLADSALRTDYFLIEEPAMEKPTQLQGMGEHHEMSAKAERKRRKIEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP94</accession>
    <name>A0ABR3BP94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Bacteriophytochrome histidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_105325</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612429.1">
        <property type="nucleotide sequence ID" value="XM_066759782.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992181"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="830"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="1206"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1607"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="310"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="654"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="705"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="775"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1442"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1565"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="710"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="794"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1444"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1565"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0244062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1782" mass="194933" checksum="91EA3319B367B8E3" modified="2025-10-08" version="1">MIDGHRQRNQDSLQRSISNNSKPLRSPAFSDARQFSTDAAEVLHDGPDADIQTIAQMLQQDKDTSLKGKGKHQPGVVTFVGKAERDRRGSGGRKILGPFSPDASGHLGNLTTTDTNNDSEHRKQQDVPQSSRFEEGANDSLELSHESGRTVQQAAQTDLPTTVQRSSTLKGKIPTSGHMETSFSNYRHFPSEHYSGQRERRFSTVNKVNPPSHNSPSHLTDASHPSNPELQHPLPQHNTQRQHLQAAEMNKRTSSHGSRTSLEVDESGMRSLISDMSGIVLLGEAGSLDSMGDSGASGFKGIIGGSGATRTGDSASIGSAHATGSRGQGDERQPTRASLAARHRHKRQASRQDSVRSFIRSQAGTTNLQDPNAPTPSPMPSSSHLPGDSQDIVVSMEDSANNEKLREQQQEEEEAREDGKEENEQVGQPITAAEDADEHAVTMRFEHVATEEGHHIVAGREGKLRRCQDEPITTPGAVQGFGVLMVLEEDYETGNLAIRQVSENSTEILGLSPKYLFKLDCFTRLLSLDQETILRDTLEYLPESCGESNSVEDGGPSIFLLSGYGEPGSDVKEDGIVGDPEAEVRSIPSSVDGKRKEWTCWVAAHRPEHRGWNKVDEKGEPLPPPDWIILEFELERDVYNPLVHLSENAKISTATADSTSQSLDPESAAAPASASGSNPNTNTLSASTRSGERALDSLASTLAGDRVGVPAGLGSGASSSDASPPDSGSSASDLTSVPKQEERMGLDGLEMHIPLEKILQSTTNHATPLRALERMRRTANHASNETRSRERGRGRGGRQRPIRRKSGGTGAMDIFAVLGQINDQLGTAPDLDTFLKVAVGLMQDICRFHRVLIYQFDEQMNGLVVSELVEWGKTTDLYMGLRFPATDIPPQARELYKINKVRMLYDRSQTTARIVLRNKEDLDQPLDMTHCYLRAMSPIHLKYLGNMSVRSSMSVSIMAFGQLWGLIACHSYGQHGMRVSFPVRQMLRILSDSISRNIERLSYAQRLRTRKLISTVPDRSHPTGYIISNAGDLLQIFGADAGLLVIGDGCKLLGRTEQGQAMLAIAEYLRIMRFDNLKASSSIKRDFPDLVLPRASDTIAGLLYVPLTAKAGQDFIVFLRKGQVREVQWAGKPYKDDKASEEASLEPRKSFKAWTETVTGCSRSWTDDELESAGVLALIYGKFIHVWREKQTAMASNQLTAILLSNTSHAVRTPLSQIINTLELALAGNIDGDVRKMLENSHQASRALLFHVHDLLDLTRIETGNETAFNDPFDIRQSISDAVRLYQTELARRGLEFRVNMTEDLPQYVIGDSRKIKTVVSNLVANSVKFTEKGFIEVYCGIHRAADGGSSQASVGESKEGNTVTIEIVISDSGCGIPTVQLEEMFVTLEGAEPLQKDTGVGLGLAVVARIVEQFEGQLRAESEVGVGTKFYFSLPMIAHETGRSSSRQSSHNSRNTNSSQLRTRTGSSGSKSESVVSLRSDGSGVPEIVSFVQDFSSSHLPALVGDDDQRLLEAQERMSKSGTYPVTDSSYPIRATKINTEDQHVKSAKPKKLRFTAIGSLKCSDSTTTSKASSTSQSSAFSRPSSSSGQGPKRNKKGPNGETVMRVMVVEDDPINSQILQKRLKMDNHVVIAVTNGQEAVDLLEKDRDIDAILMDIQMPIMDGRTSAKEIRKLEARTPHPDNIEPFKVDGRTPIFAVSASLYEDDRANLAENFDGWLLKPLDFSRVRVILEGLENSDKRAAEVYRQGNWERGGYLKAAPSPALCAASTPSTRSSPCTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPK2</accession>
    <name>A0ABR3BPK2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613064.1">
        <property type="nucleotide sequence ID" value="XM_066758616.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990994"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="118" mass="12977" checksum="A67845178666A615" modified="2025-10-08" version="1">MPLFRPRGKKVVTSAVIPHSTLNAGNAASTFRSFLPAACMASFLPSPLLPPCSRVVFFLSSFHKYTNRQSATFPEIRLLQTLSGTLYLSLNTTVTIRGSEYIITTPYFLSSFLLPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPL9</accession>
    <name>A0ABR3BPL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCA2 OB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613103.1">
        <property type="nucleotide sequence ID" value="XM_066758655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991033"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCA2 OB1" evidence="2">
        <location>
            <begin position="496"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="752" mass="83130" checksum="7E6F14D703EB22A9" modified="2025-10-08" version="1">MPTTPSAPPVLNSCASRVSPNDIAEQDIDDLLSGITAEDLDDFASTENENRREDGPGTAERTRAIDLNPLPVKAEESFAGFSTATGKTIAPPSKAALEKAKRLWHQMGEDDEIEVLAANSPAKHQRVDVSVEDKSTTPSAGFQTGQGAPVPSLSSAHSKKAPMIFQEGLTLFNPSVSSSSMASVIPETQSGTSPTDFRIGFQTGRGATIAEPSSSARRKALNMFAEVESTTNCLLDIPSAPDNPQSGVPSSFLLASGKSAPTPNRSSVAKVMSLFADVESSSSPQPTPSQPLRSSAQHQLPASHPSTPLRKPLMATTNTYLSKAKSNAIKTPVTGPRRIGLGVKSTGQRSRPEFVTPFRTAAIPAKRSMTPNAQIQTKPYYPVFDLTKLAGMGIPNDICAISPATAQYYRFLSNENIHVGIDEALAAMRRCRCAFVTTEWTKNHWVQILWKLAGEVQAKPDLLTEKWSWEEVISQLKYRVSLVSHNGHLSGEYWSLQSNSEEADVFEAHKSCRLVLSGNSTSLARWHARLGMQSQPYVSGLSSLSVDGGIITLMDIVIERLFPIAFTNGDRNIRESPWDEEEEKRRQDKWKYAAETSSSGWQEESSDTMESEFEELLHAKDLLSRVRNFSSLQISHLAHYAQLRLSREMEECRIEVEAELETMCPPRDVRDFRMIRFKDGQEGRREAFRRGMLSVWDARALGSTTLKERKRYLVSNLIPGKSGDWRVGRGRTRMAEVYLHTRRDSRWIALQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPR8</accession>
    <name>A0ABR3BPR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613152.1">
        <property type="nucleotide sequence ID" value="XM_066758704.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991082"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23327" checksum="60929FA7C534249C" modified="2025-10-08" version="1">MLYTPGDRHCHILPSHLPSFLPPRPLQLPLHDPPCPANRRTRSYPHRRLQGQSKTVAELAALDQEDESLQRWKQSLGIGAGASGGGEKRVVLKSLFLSPKMLLQSSKRIQEGVEYSVGITFVIENEIVSGLKYLQVVKRSGLTVDKTEAMLGSYGPQQEPYTKVFASEESPSGMLARSGTYVVRSRVMDDDNTIWLDFEWGFKLGKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPU1</accession>
    <name>A0ABR3BPU1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104248</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613174.1">
        <property type="nucleotide sequence ID" value="XM_066758726.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991104"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059098">
        <property type="entry name" value="WHD_MCM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23669">
        <property type="entry name" value="WHD_MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="12">
        <location>
            <begin position="502"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0247213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="932" mass="104689" checksum="71826DEA30200242" modified="2025-10-08" version="1">MSSPPIPPSSQQRPKRPRSRSRSPTAGPSGLRSSPPPSSLPPSSLPPSSPPIPFSDFGDEQDVADDEAEVRRIGRENGDDDEDEEGEDLFNDDMMADYEENAGLDTYSQADLDDRSSVAGPTRAERLAAERAMDLRDRGLSGRRAGRRDHMPAFLQSDDDEAEAFGDDPLAGINVRRRRRQYDERMDEDDVEEDDEEMSLEHLGDVKAASIAEWVSRDAVRRAISKHFKSFLMTYVDAQGNSVYGQRIKHLGEVNSESLEVSYIHLANTRPILAYFLANSPQPMLELFDQVALDAILLYYPSYDRIHSEIHVRITELPTSLSLRDLRQSNLNCLVRVSGVVTRRSGVFPQLKYVKFDCQKCGATLGPFYQDTNKELKISFCQGCESRGPFVVNSEQTVYRNYQKMTLQESPGSVPAGRLPRHREVILLWDLIDMAKPGEEVEITGIYRNNFDASLNTKNGFPVFSTVLEANHINKKEDLFASMRLTEEDEKMIRAMARDDRIAKRIIKSIAPSIYGHDDIKTAIALSLFGGVGKDINRKHRIRGDINVLLLGDPGTAKSQFLKYVEKTANRAVFTTGQGASAVGLTASVRKDPITKEWTLEGGALVLADKGHCLIDEFDKMNDADRTSIHEAMEQQSISISKAGIITTLQARCAIIAAANPIRGRYNPTIPFQQNVELTEPILSRFDVLCVVKDAADPVQDEMLAQFVVGSHLRSHPLFDKEYEEANVSTVVDADIIPQDVLRKYIMYAKEHFRPQLHQLDQDKLARLYADLRRESLATGSFPITVRHLESMIRMAEASAKMHLREYVRSDDIDLAIQVAVGSFVNAQKMSIKKTLERGFRKYVHQATDHEELLSFLLGGIVKEKVQLYRHSHGENPARVFIKVSQLEGRAKELEIYDVQPFLRSRLFSTNGYKVVDHDGARSIEKAFTIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPW4</accession>
    <name>A0ABR3BPW4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ZIP4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612895.1">
        <property type="nucleotide sequence ID" value="XM_066759408.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991803"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0245811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="800" mass="89927" checksum="FA64C5B1FB54F18E" modified="2025-10-08" version="1">MTALLEAGKTPMASQLALQGAEYEQLITSSTTIKEASEFKQKVTVLVWYYMARIDFLLREGNDSFAYDLLYKATQLDETWSMTAQECRLLASKCWTVGNHMLNERNNVAGSIDWLKQGILLIEKLINRGVQLDHLKELHIATLKSLSRAQLMKAEENPHALNSAAAALNELGELVADSDQATLHEMRLLQLHILKTRKAPEGELRIVMEDIMKLTDWTEESVLEILSQLASLIGQYPAFPSQLVQTYLRLALASSAGHPYVRMIMYEGLLFMKALSPPTAGVRIAAGILDMISKDPDYQLDDKVSAIACQTLLWNIGMFNESKERITEAAHWYQLAAHTVFKELGGENISRCFRKAALCHMKMTDWTAALDLISLCPKEEASTHYLAFLAAIRQGREEAAIDAVSSIVECSDFEAQQLVLMTSLANEKGAKHVLIASMRALLNALTDSAVKFDVQIETITVIRCLIRMTAMELAHAEDKDRLVESMIEYLQTAIDILSEDPTRGQGQMKGIAWLYKCAYNVAVQSLNTLSSKSLADLFDASAQLMSIYDVMETSGATDPDLHFVRGSAMFACLCGKIFFCRDLSSGPDKVLLLDQLLDYIPHCREALSSVKSTHPRWPVISHMRRIIDTSEVELQCESNEWTAIPPILQRITKAHSSGEISETNRTLEMTANVLFQYEECPSHTKANDIKLYSRWMRAILRILLHHNGAEEEAESLKYADKALDILKTSLGKSAYPLDEIQWLVATFWNKGLEWFSSSRVSQAKAWCEIAMTIAANTPELNIDRQKMNEHYEHLLSKINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPY3</accession>
    <name>A0ABR3BPY3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="4">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613211.1">
        <property type="nucleotide sequence ID" value="XM_066758763.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991141"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="6">
        <location>
            <begin position="38"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="333" mass="34721" checksum="342108564A84E4B6" modified="2025-10-08" version="1">MFRSLRATSTIARSAAAPRGFATSSVARSYEDTIKNILINKDTKVLVQGFTGKTGTFHAQQAIEYGTKMIGGTNPKKAGQTHLGLPVFGTVREAVREAQPDASVIYVPPPFAADAIIEAIENEIKLIVTITEGIPQRDQIRVMNALKSQSKSRMIGGNCPGIISEGCKMGIMPGHIFKQGKIGVVSRSGTLTYEAVNQTTLAGLGQSLTVGIGGDPFPGTQHIDVVKVLLSDPRTEGIVLIGEIGGSMEEEAAAYLEQHNKNSANPKPVVAFIAGRTAPPGRRMGHAGAIISGGKGAASDKVAALQKAGAIIAESPAQIGGLMLKAMKEAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ17</accession>
    <name>A0ABR3BQ17_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613249.1">
        <property type="nucleotide sequence ID" value="XM_066758801.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991180"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="172" mass="18463" checksum="899F5D4889ECB5E9" modified="2025-10-08" version="1">MGLFDYIPCCGPRKGKAPSSTSPTRENNPLLLPITQEESVISAEGPQGYGSTERLTDEQRVRIETIGRETGTYMLPIQSLPPRSHLSMSRTSTIPRSLSSGSSSRPSSPPLAQSGDQDQSSPLEETKILEGDEKDGDVVRKTLFANGTPMNLGARKTSSGKGRGKAKSKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ76</accession>
    <name>A0ABR3BQ76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_104364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613289.1">
        <property type="nucleotide sequence ID" value="XM_066758841.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991220"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="68"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="168" mass="18248" checksum="D8D54A1704016889" modified="2025-10-08" version="1">MPVATKADQELFQAITASAGFAPSLALSIKIIDADDVPPEDVKGRRKLDGWRMRYEGVVTENMTNLIGNMHGAAISWIIDTLTSAALAHLHTPTFWGPPMMAGVSLSMEIQYLHPVTLGSELIIDVQILKCTPTLANLRCEIKAKNSGKIMAVGTHLKTWKPMGIAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQC6</accession>
    <name>A0ABR3BQC6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613356.1">
        <property type="nucleotide sequence ID" value="XM_066758908.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991287"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="71" mass="8288" checksum="BF9BF661C90FF68F" modified="2025-10-08" version="1">MNYCPASPRWCGDGWEMRKEAEKRMSSKYTANRSVSVGGVNEDNFLLSQLRVNMGFISYHVMIWMYELDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQF8</accession>
    <name>A0ABR3BQF8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="10">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104901</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="10"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612849.1">
        <property type="nucleotide sequence ID" value="XM_066759362.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991757"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="11">
        <location>
            <begin position="112"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="12">
        <location>
            <begin position="480"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0245765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="616" mass="67432" checksum="3B2A108C7D3F68A1" modified="2025-10-08" version="1">MLALSRTRALARPLRSNLARNYVVASQTARATEAPNFGQKKGYPIIDHEFDAVVVGAGGAGLRAAFGLAEGGLKTACITKLFPTRSHTVAAQGGVNAALGNMTEDDWRWHMEAPHTVIELEHYGVPFSRTKEGKIYQRAFGGQSLKYGKGGQAYRCAAAADRTGHAILHTLYGQSLRHNTNFFIEYFALDLLMQDGECVGVLAINMEDGTLHRFRSHKTVLATGGYGRAYFSCTSAHTCSGDGNAMAVRAGLPLQDLEFVQFHPTGIYGAGCLITEGSRGEGGYLINSEGERFMERYAPTAKDLASRDVVSRSMTLEIREGRGVGPEKDHIFLQLSHLPAEVLHERLPGISETAAIFAGVDVTKEPIPVLPTVHYNMGGIPTKYTGEVLTVDEQGNDKVVPGLYAAGEAACVSVHGANRLGANSLLDIVVFGRACANHIKETLAPNTPHKPMDPELGKKSIDELDKIRNASGPLPTSQIRLNMQKTMQTDAAVFRTQESLDEGVAKMRDVYKSYDQVGIKDRSMIWNSDLIETLELRNIMQNAMQTVVSAAARKESRGAHAREDYPDRNDEEWMKHTLSFQHDPNSPDVELKYRGVIANTLDEAECKPVPPFKRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQJ8</accession>
    <name>A0ABR3BQJ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dihydroxy-acid dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613431.1">
        <property type="nucleotide sequence ID" value="XM_066758029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990391"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009560">
        <property type="entry name" value="PRK13017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="6">
        <location>
            <begin position="87"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="7">
        <location>
            <begin position="412"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="636" mass="68613" checksum="D8549FD078C8B903" modified="2025-10-08" version="1">MSNGACEGCTCGRAEQLQQGGDIPINRPERSFTAPADVAPYEGVEPAVPLRSKKWFNDPSDPAMSALYLERYMNFGITLDELRPKNRPIIGIAQTGSDLSPCNRGHMELAKRVRDGIIANGGTPFEFPCHPIQETGKRPTASLDRNLSYLSLVEVLFGYPIDGVVLLTGCDKTTPALLMAAATVNIPAICMNVGPMLNGYRGHKLIGSGGVMWDSRAEYAAGKISEGQFVQQVSLSAPSVGHCNTVGTATTMNCMAEALGMALPGSATIPAVYRERGACAYATGVRIVDLVREDIKPSDVLTKEAFENAIAANTALGGSTNAPIHLNAVAKHIGVDLTGDDWERVGYHLPLLVNVQPAGEWLMEEYHRAGGLPSVIAELIKHNKLPHPDALTITGKSIKENCEGDFSRDRRVILPFDKPLRENAGFLHLKGTLFDSAIMKTSVISDAFREQYLSNPDDPMAFEGPVAVFDGPEDYHHRIEHSPQIDAGTILVMRGAGPQGYPGAAEVVNMIPPGRLINQGIELPCIGDGRQSGTSGSPSILNASPEAATGGMLAYLKDGDRLRIDLLKRTANVLLSTEEIEARKKEMGPYKIPKSQTPWQEIFRETASELSEGMVIKSAVKYQRLAQTAGVPRQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQL6</accession>
    <name>A0ABR3BQL6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613447.1">
        <property type="nucleotide sequence ID" value="XM_066758045.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990407"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="235"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="744" mass="82162" checksum="D89259D7255193FF" modified="2025-10-08" version="1">MPSSTLPPSRPLPLRHLLETYTTSHPLRTPSPLPPSSRVDPKLRQRLPPPTSASPLLWTLPTWWLFIRFVFTKGIHIALALISHFLFGPKRPSWGYRMTFITSFMRNIADHSSLADIALIRRFISLHFLVPLPGDAVVTPITFTVPPRKAEQVARGFLRDLDVAETGGRQLSGEWVVGTEVWKRLRAEKRARQKKQRASPRYNLSPNEENSKQTKIEIEPEALKQKGKASERVIYYVHGGAYYVGNAATHRLVTIGVSKSCNARVFAITYRLAPEHVFPLPLHDVLLGYLRLLSPPLSIPPENIIIAGDSAGGGLSLALCMYLRDEGYRLPAGLVLMSPWVDLTMSCGSWDENADSDVVPRPETDDHLNPVGCYLGPEGIATYLTHPYASPLFGDFHGLPPMLIQSGDSEVLRDEITLVAHKATLAGVNVTHELYEDMVHVFQMFSFLPATMTAINNVGVWVRTTLPKIEKEQRQAAGMDKDQQEVGALDVDVTESMEEEIGKGNRVVAKDGQEIGVRSGRTEVMPEEIDATQDLSRQQASISKKDFSRRSTNERPTVDTDSLAKLDSDSDSGSPTPTNSRLSSPSIAFPREPRTPPRHSGPFMDVQQDQSQSSQPHTLPRLRRVQTTVPMAFALSPPPNPLSSTRRRRPTTSSLLTSPSSPVYGQDTSYPASPTLSASARKRLRSGTLSFQPRPTTRIRSKSHSDIFNLVEGYVEGGAANETTVYAAGGEVKSVGVLGEDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQQ5</accession>
    <name>A0ABR3BQQ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_105199</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612303.1">
        <property type="nucleotide sequence ID" value="XM_066759656.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992055"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0243936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="289" mass="31708" checksum="72910421634D5394" modified="2025-10-08" version="1">MAASTSLLSQGTLIKQGAEAKVYALPSLFPEPTIYNPASSSSSSPSPPTPVVLKHRFTKTYRHPTLDASLTSQRLTFEARALARAAKAGVTVPKVVWVDEKAGVIGMERIEGWSVREVLGGGAEGEVEIIAKQEIEGDVENKIEATPIREEPEETENEGLKALKNLGVTEEHLMRSIGAALARLHKTMIIHGDLTTSNMMVRLTPGGPGPYEIVLIDFGLSFQAQFPENYAVDLYVLERAFASTHPRSEKLYAGVLETYAEGLGEKKWKPIQIKLKDVRRRGRKRDMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQU0</accession>
    <name>A0ABR3BQU0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613499.1">
        <property type="nucleotide sequence ID" value="XM_066758097.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990462"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="140" mass="15936" checksum="9ECA969167599100" modified="2025-10-08" version="1">MGSQSSKTSLEPAPSDSRAPTTLQTPQSKPSKKKKKTKPFNYDKAFNILAAYRPPSYSPPVSTLTEPRGWENSSLLPSERLRRQLEEMEGEIMAKRRMREYQARVGSSNGRRKAVRKEERVKKSGDHELPEYDVAISKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQX7</accession>
    <name>A0ABR3BQX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_104693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612645.1">
        <property type="nucleotide sequence ID" value="XM_066759158.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991549"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0245561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="204" mass="21807" checksum="BB8F64485DEB0717" modified="2025-10-08" version="1">MSTVRTEGIFPSIIFSILAFTLGYQAHSLLSRSTPAVAAPKSPKGTRSPRKFQQQDDYESASDTESDASDNAAALATDLSDIKYSSFEEMKLVLVVNDELKMTKGKIVAQAGHATLACAMTLKEANPKLFKAWQMQGQPKIALRGANTEEIETLAAQARSVNLCARTIRDAGRTQVAPGSKTIVGIGPGPAKLINTITGKLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR02</accession>
    <name>A0ABR3BR02_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613581.1">
        <property type="nucleotide sequence ID" value="XM_066758179.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990553"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF2">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="34908" checksum="D4FDCDF4A4F6FD22" modified="2025-10-08" version="1">MAPETVTSAGTKYNETAVFTADGILFDMDGTLTDSIAAVEAAWTAKAKEFGLEPEAVIKATHGRRASDNLQDLIPNLRKEHIDLEVEKFEQSILAFADTPPRSRRSSSASSTRTSRSGSRSMSGSVGSFAPLTPMNSCTLAAIKPFGTYEALNLTSIKLSKSGEHEPQLDDSVFEDEADDLLDMSVRILPGVRSLINSLPQDKYAIATSGAKTYCHGCLDRTGITIPKVCVTADDPRLLRGKPFPDPFLLAAADLGIDPTRAVIFEDSPSGIKAAVAAGATVIAVCTSHQRHQIEHLDAHFVIDTMDQVKVGQGKHGQLEFTVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR17</accession>
    <name>A0ABR3BR17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">aspartate kinase</fullName>
            <ecNumber evidence="2">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612690.1">
        <property type="nucleotide sequence ID" value="XM_066759203.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991596"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04247">
        <property type="entry name" value="AAK_AK-Hom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041747">
        <property type="entry name" value="AK-Hom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="8">
        <location>
            <begin position="208"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartokinase ACT" evidence="9">
        <location>
            <begin position="538"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="615" mass="66088" checksum="D4A869BC249FF7B6" modified="2025-10-08" version="1">MSSASTPTAPYLEDLIRNSLDQDIPWVVQKYGGTSVGKSLDNITKIVGSYIDNGSKVAIVCSARSTQTKSLGTTNLLLQASREALQPAMSSSGDGQSGSVSGTATPFYPKRVGSGFFGKDQPTSMTSSVSSLSQLDSQLGRSGSPSPFQSSCSRSPPRSPITPSQDPSTSQEPAFHTTVDLIKKGHLQAARASLKEGPLRDELEEEIERDCESLRSFLYAAQIIDEISPRSQDSIVGTGERLACKIVAAALRDRGVDSELVVLDNIVDASMAAASEAVSVDAGDQGVAQLGQEFYDQLSIRLGERLRECGQRVPVVTGYFGPVPGSLLAQIGRGYTDLCAALCAVGLKASELQVWKEVDGIFTADPRKVPSARLVPMITPDEAAELTYYGSEVIHPFTMEQVIRARIPIRIKNVENPSGAGTVIYPDVGFPRGLDTEPPKAERVLEGVDERMPTAVTIKDQIIVLNIHSNRKTLSHGFLARIFGTLDRAGVVVDLISTSEVHVSMAMQDFLNRKRLERLVKDLEKIGDVTVSKDMAILSLVGRNMRNAIGSAGLMFASLARAMINIEMISQGASEINISCVIENKDAIKALNVIHESCLSYPRSPTTTMAGLKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR85</accession>
    <name>A0ABR3BR85_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Swi5-dependent recombination DNA repair protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613657.1">
        <property type="nucleotide sequence ID" value="XM_066758255.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990630"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="69168" checksum="EC429F61BD1117FB" modified="2025-10-08" version="1">MAIIKRPRLTVTHVQKPDPRQDRHDTVKPFHSVSRPWPIDQKKGDPVFILSQGLRQRLYHPWILPIPSFLEIYFPQASATEYITQRPLSPICLSIVDYGYNPNRLITYRNRTTIFTDQTAAQEERAIVELSDYPIPVYKSQVQDSPSVIQPITVRHLVSPTSHSPSLTIVEDSHYEFIMPEYDNPVTDDYDVMDVRSEHDGELFDTARNDFDAKYQTPVQEQTSLVKGRKKRPLVNKIILRPRFPSPDVFLSEEKDEDSNKRRRSYEDDEISYSSEEQWRVGRIPGHQGCHSMSGRKVFGSDSERSGQKRSLSESISGQAGRVLKKPFRPPTRVILPKASPKPPASPLTADTPDSTSDSNITSTPSTSTFTSTSTNTKPFKTPIRSDRSNAPSPSTLSLPSANRRQQAAILTVQNEVMLLKKAVKYENENSATHLKELIIQWRNGGREMVERLFSLIPRPLDDSFLHSSAYAPNTFSSRWYEGPSTLELSPEQQHYLAKASLNKDDEPVDAEGNLLFENEEEQDVVKYLQKMGENKMHEIESRQFRSSNVERAATRTGGSKMDDHLTCKIAEESSLNEWNYGTLMRGLGVDPPLLGWDACVEDWIDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRB6</accession>
    <name>A0ABR3BRB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613697.1">
        <property type="nucleotide sequence ID" value="XM_066758295.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990670"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="40"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="42436" checksum="6203666F3351B8DD" modified="2025-10-08" version="1">MDQSDCSIANDQADEAHVEDYLNANHDARAGNMSTDEKQCRICFSGPEEQDALGRLISPCMCRGSMRYVHVSCINAWRGTGANAKAFMECPQCHFRYQIRRTRVSGLATSKPILLLCTFLLFSILSITLGSILRFLLTHSTTSRRLLSSSSPVSVGTPFDLFGGEFIDRGGGVVIVGGSGALVWDILLAAVKTFVSLADRMTYFQSLLHEFLPGPLAVFLSALVVRFVLGLAVLGSLSFISLSISLSLFGPLQLANALRGGFLGSWGRRRLARNGRDGGIGTVIVVVLVVIGAINTLRQAYEGVGRLAIKLLKYLETQVLEVNPDEIRRNTRPSNERWRAIWHEQWTWNGWKELGYRCYIMVEGWLRSIWALWTPAEHEHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRD1</accession>
    <name>A0ABR3BRD1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U4/U6.U5 tri-snRNP-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_104861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612810.1">
        <property type="nucleotide sequence ID" value="XM_066759323.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991717"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0245726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="77230" checksum="9C66E623FB497125" modified="2025-10-08" version="1">MSMNKESLTVEEAIQLRLQLGLSAPGVAAADGGEPPVDTDAIAEENYAQRKAEMKREKEERELKERIEKARNKSALNAKLKGATLSTASTDDSLDAKSWIKKQKKREKQRAREIAAMQARDKEEQDRLMYGEEDLAGLKVGHGVEEFEEGEDVILTLKDTGVLESGEDELQNVNLVEDAAIKAVKERERKAQQAYTGYDDEEFDENRIGQRADVLGKYDEDFASGKVRTEGFRLGAPVEKKMKIQDEDEGMGIAPAQKVKLSLDYTKEFEVSDYAKEGEAGFKKPKKKKAKRSTRRAEAEEDTMEVDGEPTFTRRVVTEGPDNLVDDDDLQAALSRARRANAKKKPKVKPEDVAAQIAQRKQEEGEQVKEEEDGEDDGRITFDETSEFVRNVSLESRAVSVKRERISPPPSEVTPTAAEVGPSEEPVVVKIERREEGEVDDEDDEMGEEDADLAEIAAREGMSLEEYREKIDRQMKEMEDMKKEAKDEDEPEPTVGHGMAGVLALLRHQGALKARTAEDEERERVQKQKDLWLADYRRRMAQRELERIQARGGNKDQAQREWENRMREQQEARDALDIYKNYKPDVNIVYHDEFGRRMTAKEAWKSLSHKFHGKTSGRMKTEKRLKKIAEERKQLTMNSSDTPLGMTDAFSRRQQMTGEAHMVLSVGNKQSVQAGSSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRD6</accession>
    <name>A0ABR3BRD6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612528.1">
        <property type="nucleotide sequence ID" value="XM_066759041.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991426"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01297">
        <property type="entry name" value="D-aminoacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.130">
        <property type="entry name" value="D-aminoacylase. Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023100">
        <property type="entry name" value="D-aminoacylase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="2">
        <location>
            <begin position="58"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="557" mass="60828" checksum="A254E81EEEEA1B85" modified="2025-10-08" version="1">MSLNQTGSDILFISPTVISGEEHAQPHLADVFVSGGRIARIAQPCTLSDQLGAEVRKIEAKGYVLCPGFIDLHAHSDLYLLTHPDHEAKISQGCTTEVVGQDGISYAPVQTETQMKAIREQITGWNGNPNEEDHPGIGLFEWNTVGEYLDCLERNKTATNVAMLVPQGNLRLLACGPWDEVATADEITAQEKLLRQAMLEGAVGMSSGLTYTPGMYASTSELARLCRVLGEEFPGAFYAPHHRSYGFKALESYAEMLGLGRDTSCPIHLTHATLNFSENKGKAPLLISMIDAARSDGCDISLDTYPYLPGCTTLASLLPSWASSGGPEETLKRLQDEISREKIRRAVEDTGCDGGHGIPTNWDEIQIGSTVHPDLAAYSGRRVSEVARSLKVPSIKIFFDVLIKDKLATSCIMHIGNEENVRKIMCHETHCSGSDAILHGKSLHPRAYGTFPRFLGHYARDLGIMPLPAMVAHLTSRPAKRLGIYPSRGCIAEGSAADIVLFDPATIRDKSTYEEPKQKAEGVRFVLVNGEVAVDETRLTGMRGGKVLRRREDGMVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRF1</accession>
    <name>A0ABR3BRF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613450.1">
        <property type="nucleotide sequence ID" value="XM_066758048.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990410"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="27"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="303" mass="32618" checksum="360A35B901279D77" modified="2025-10-08" version="1">MSLDTSSSAIHLQLPPTSSSIRPPSQITVHPSVIAQILTHHSRHPADSESTRVIGALMGNRSDNGQEVDIRSCFAVPHTEQGQQISVDRPFQQDMVNFLAKNGTKEVIVGWYASQKTVNSNSAIIQEYFSFETNPYPAVHLTVDTEIEESGKGLGVKGWVSQPLGLTSKSECSVFVPVPVSIKYADSERAALDLLTAPQPTLSPALPPLPTLSNSLSQLSSLIDQCLAYVQSVNNGSQTPDVEVGRYLLEGLGRWSASGNEDEGGVKAGLQDTLTVEYLSSLVRSQVELAGRLSLLQQPVAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRG0</accession>
    <name>A0ABR3BRG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I308_104486</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IND107</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613408.1">
        <property type="nucleotide sequence ID" value="XM_066758960.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991342"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="18">
        <location>
            <begin position="885"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL0247447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1412" mass="154059" checksum="64F125441362AC8A" modified="2025-10-08" version="1">MSVNALELTPAELKQRLDRWSSRLGALPSLALPTDYPRPSPAKLVEAYQSMPIPSSLATAFMKLTLKFSTLFPASGLPTPFHILLASFAILLFRYTPDPSLVICTSANASTQPLLLKLDIAAEMTFFDVLRQIMEREQEAQADAVPITKLVDHIKPEGPLYRVRFLDSTQVESDASSSLTTDFTLFLLAAPNDTPATRTSVPPLYLRLTYNSLLFTQSRITATLESLLQLLSSAASHASHGPAHPIGALPLRTPSQSAALPDPAADLDWCGFVGAIPDIFSANAKAHPDRVCVVQSELAEGQTVMDGPSRGRRIFTYRQIDEASNVLAHALLKNGLQRGEVVMVYAARSVEMVVCVMGILKAGGVFSVVDPAYPPSRQTVYLSVSTPRALLVISSAGNLAPSVSDYISENLSLRLLVPAIQLTSSSITGSRSDAAEDILAPYQQYAQTPSGVVLGPDSPATLSFTSGSTGIPKGVKGRHYSLTHFFPWMGKRFGLDENSKYTMLSGIAHDPIQRDMFTPLFLGAQLHVPTADDIGTPGRLAEWMADSEVTVTHLTPAMGQLLSAQATRHIPTLKNAFFVGDVLTKRDCTRLQSLAKNVCIINMYGTTETQRAVSYFAVPSVNEDSTFLATQKDLIPAGQGMIDVQLLVVNRTDRNIPCAVGEMGEIYVRSGGLAEGYLDPSATAEKFVNNWFGQDVERPDTLKEKNPAAAEHWFGIRDRMYRSGDLGRYLPDGRVECTGRADDQIKIRGFRIELGEIDTHLSRHPLVRENVTLVRRDKDEEKVLVSYFVPVEGDELEGLMSASEAAEDDEEIDLKTQMIRGVKKYRKLIRDIREYLKKKLPSYSVPAVYFPLHKLPLNPNGKIDKPALPFPDTSLLAPAPAASTADHTPTQKTIHDIWLSLLPSPPPHIALDENFFDMGGHSILATRLIFEIRKAFVVNAPLGLVFDKPTIAGQAAEIDLLRNADLSGAGEGALEAEKAVDYAKDVELLSKDLPTFSALPDDFATKDLTVFLTGATGYLGAFILKDLLSRRVRKVICLVRAKSANQGLQRLRDSGEGRGVWDEDWVKQDRVEAVIGDLADEKFGLSQAEWDRVAEEADAVLHNGAIVHWVYPYPKLRAANVISTVTALQLCAQHHSKQFSFVSSTAVLDAEAFVDKADEIMEAGGKGLLENDDLEAGRTGLNAGYGQSKWVAEKIIMEAGKKGLSGWILRPGYVLGHSQTAVTNTDDFIWRMVKGCVQLGLIPDINNAIICCPVDHVARLSSLATLSASASSAFNIMHVTGHPKIRFNDLLGSLLLYGYDVKRVEYVHWRTKLEQHVLETQDNALFPLLHFVLDDLPTSTKSAELDDTNAQNLAAAAGEVRTSGVTEKEIGLYIAWLIRAGFLEKPQKQGKVLPVLEGGAMKAIGRTTAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRG4</accession>
    <name>A0ABR3BRG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-1,6-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613746.1">
        <property type="nucleotide sequence ID" value="XM_066758344.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990719"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="56876" checksum="4F5C2E35B7CB4967" modified="2025-10-08" version="1">MSFLGWLNRRSNKYSSLPTSNASSGHPNPELFQSSLARRKKLLQIGLGAVFSLLLFGAVVRHSALPQSLAIGQNDYEWQGGVPAMTGDLSANPNQKNPSEDSGEAALESEMPGWTEAMGWKSSNHKGLADLGEIAEQRYRLNVDAEERGTREYFRRLYDFAVTLPMRLHSPFLSSLHDHLPPACIDALPDYPNSQRYLPSMVSYKNVHMTDKTFDPQSKFIQSWAETNSKDGWRINFLDDQQAQDWVEMNFRRTDVEWAWDFMHRGVLKADFLRYLLPLIHGGVYSDVDTRPIRPIEQWGQLDVEYLDLTATDGPSWRTALSTHPSVIVAVDVDVHSKQGWEHSWPRPLGICQWTLSSAPNHPIFLDAVRRVVNASHVVQAWEVRRDEEITRLERERPRGWSQEVDRLQKLGRSEVMNVMEWTGPGLFTDSVLAFLLARYNVTWHRLRGLEHPLRIGDVLILPITAFSPGGEKDFRAEGPDSPQANVLHNFRGSWKSDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRL5</accession>
    <name>A0ABR3BRL5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-processing factor 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103619</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613510.1">
        <property type="nucleotide sequence ID" value="XM_066758108.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990475"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="380"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="84493" checksum="EE0925B6E0EF0DFD" modified="2025-10-08" version="1">MSGEEKSLWSEYKNAQGRVYWSHAVTKQSVWEKPDELKTPFEKALAKTQWKQYASNNRPYYVNTVTKETKWDLPPELVELKKQIEEEETRNAERQRRKEQGIASPTPSPRESRSPTPEDIRELRASAANAIALYKPSTATPASVPDTPLKPQNDDLPVITMPPGGFETKEEAEAAFIHLLKKAGINETHTWDIAMRIIVLDPLYNALDTLAEKKAAFEKYTNGILDERRAAKDARISRLRPILHKMFAKSGVIKSYSTLKTADRAFGRDRYWQEAFPEERLLLLDEYTSKLRRDEESAERELRDRNIITLTALLPTLDISVSTRWRAAHDLIISSPTFRSDKDLQKIEVLDMIKVYEDYAYKLEQEHKEESRKLKIEATRNARKAREGFKALLKELDHNGELTRTSKFKDTYPKIKNDERYIALLGLSGSSPLELWMDAVDDISEEVERAAEKINNALSKVDKKIALETSWEELEQWCREVHMDTQIAEKLRKEVYNLTHSRLRQIADEEARRIERRKRRRIEDLRYALKKVDAIELDMSYDQALPHMQDLEEFKEIEEEDDRKCAYEKFIKRQKEKLSEAESSKRDYRDRGDSYRDSHRSGDRRHSRDDAMDVDDDVKSRRGDREREKDRDRDYKSSRRDDRDRDRGDRRDRDRERERDKERDRSDRRDRDRERERKHGGEQGEHREHKRRRLSSASSAAPRKDRNDEEIEEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRR9</accession>
    <name>A0ABR3BRR9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613841.1">
        <property type="nucleotide sequence ID" value="XM_066758439.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990814"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="142" mass="16366" checksum="027BDA91BBF70CA4" modified="2025-10-08" version="1">MEGLYNFRELYTIPEESSQVDHCLVINFGTSAFVDSSGSGTGWKLWLRTSYLSQVNVITVIAYGDTTHRWITSPILIFWVVKQVTRFKREPQQAVSGHDRRFAKPWGQDAGLRIQPQSLSFIGWCYSFFIQILGWREDPRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRS1</accession>
    <name>A0ABR3BRS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104728</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612678.1">
        <property type="nucleotide sequence ID" value="XM_066759191.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991584"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="150"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="532"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="859"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1032"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1033"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1057" mass="114389" checksum="76F97036C9365D37" modified="2025-10-08" version="1">MKRAWDSASPSAFSSADSTQQSTNSDQVWVQMPSHPYAAAYSSMANPFTPSPLHSSTTFDAQTLNSASASASGSGRQEKRPRTGGSDGKRNSPQGQSKDGDSEGEGDDDDDDDDDENDDESGGNKGASSKKNNSTKAVKGTDGKQKTKLTRGSRACVACRKIKMRCIPDDAAAGQGNGICKRCKAGGHECIFEESNRGKRSSRKNEAMAAKLSKMEAALKNIGAALSNIDQSSLDSFSSALHSSTDDPDVINLITSHASSAVTPNLAIAMNRNSFPSSFDDRTHGMSHEAGHTSQPPLSPRLHSLPDNVLSPLGLLAEASLQNDASKRNFTKGFGTANSLGKSLARPLPGERLQMQRNGNISMNGAATFRMATSDVRGGRIEDDENFGGDHRLGVSDQNYFKPGGSVAFFPPMPADHRVPELLTILTREEIGELFDIFFDHMSFHVPLIYKEFHTPDLVLQRSQFLCTVICAIAARFYHKKPELHHSLSAYAKRLAFEVPSRGYKSVEVVQAYLLLSLWTLGPEKTFEQDRTWLMLGMAIRMATDLNLHRKSMMSNLDTEEGRARDLEIINRERCWLHCFVLDRSLSAQMGKPYSLREDYIIRNACESVWHQQKFALPSDAALSAYVMLQQIMSRAIDSIYSSTTTVSGLRHDCDYMLIVRSAHEELRRWLADAKNNKLSSSEISREFDSRANFYFAYSSLVLYSFGLENALEKAKMDISFFLTNVYEAATKVCMVVKEEFLPKGWLPYLPDTNFVMCSYALLSLLKLLKPELRPYHDSEESIFNLVTEVADILEDCAADPSHQPAIYAAFIREIVRKTKEMRYGGTATAPASPTSHTIAGHMHGIVPGEAAAMGMAGNGRAAGEAPAASTRNDAETGASAANATVDGAQGAQNGVYDPSLMGQSATNWHPDVLPHETQFTYIPQGGDMLILPSQAGPSIAPSPTSAFLANPTGTSTNAGNASGIGAAAGTGGSHFGTPSGSTGWAEYLPTFMSSDGFDGWDGSMLLPGFGKGQITLSGGLLHSQHGSGIITPLQQTPTQSRMGSRAGSRTQSPHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRS3</accession>
    <name>A0ABR3BRS3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613681.1">
        <property type="nucleotide sequence ID" value="XM_066758279.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990654"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046816980" description="Smr domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="3">
        <location>
            <begin position="208"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0247720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="312" mass="34079" checksum="B6EACDAA2F3B3817" modified="2025-10-08" version="1">MSLVSILTSLLKICCGSQEPTGPQQQQQHQQYGYPGTVNQQQTAYPPQSQPSWANVVAGGQQSQFQHQQYQPQQHQQGWQSPMHQQQGGWQSPPHQNGYPAGSPSPFHLPAGGVIGPHAPASQHMNEDQINATNQHYVELRNKARKEGDEAHRCFAASQAAYQAGDGAKAHELSVQGKAHQRTQDQLDEQASAWIFNENNKDSPAGTIDLHGLYVNEAIERTEAAISDCQRQGREELRVIVGKGIHSQGGHAKIKPAVENLMKKYNLSAYIDPENTGVLVVDLEGKQTGPRSRDIGGMVDSLGKADEGCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRU7</accession>
    <name>A0ABR3BRU7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_103985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613868.1">
        <property type="nucleotide sequence ID" value="XM_066758466.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990841"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0247907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="102" mass="12199" checksum="43F64D4070548242" modified="2025-10-08" version="1">MNDRLLYREALGRFLSYFSPQETHYKIHIYNYARKSTESEEDVKRKVFKISRREYAKKREFDLLCPRKEAREEPGGLQILWAPLNASQSKRGKEIISNPYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSD9</accession>
    <name>A0ABR3BSD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_103173</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614057.1">
        <property type="nucleotide sequence ID" value="XM_066757673.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990029"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045791198" description="alpha-amylase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="15">
        <location>
            <begin position="34"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0249870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="532" mass="57172" checksum="06CAEFEAE7372952" modified="2025-10-08" version="1">MLAHQAALALIPLLSFLPAYALDANAMRSRSVYQVITDRFARNSSSTGDCNVADRKYCGGTWSALAEKLDYIQGMGFDTIWISPVVENIGGTTGEGEAYHGYWTLDPESLNSNFGSADELKSLSSSLHNRGMYLQVDVVINHVAATSSSTFQPSGAYGPFSTSDDYHPFCWITDYNNQTNVEQCWLGDDSVALADLNTESNTVVSYWNNWIKELVSNYTVDAIRIDTVKHVRQGFWPDFVNAAGVFNQGEVLLGDAPYVAGYQKNASVNPFNYPVYYPLVRAFNGTGQSFNELISMASSVNGNFTDPTLLGSFLNNHDNARFESIVTDTSLIKNAQAYPLVTDGIPYVYYGSEAGFKGGNDPDNREPMWTTNYDTTSDMYKFFTSLNAARSAAGNASSTFYTDKMTLSQPSETTLLVAKKPLISVFSNGGSSASNVSVSVDSSSSGWAASTKVIDALTCESFTTDGSGNLAVTISKGEPRVLIEDSQKGSLCSGSSSSSSSSSKDSGAGMTTRVGGWVALAGIFVAGLQVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSG5</accession>
    <name>A0ABR3BSG5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614087.1">
        <property type="nucleotide sequence ID" value="XM_066757703.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990059"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16667">
        <property type="entry name" value="RING-H2_RNF126-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0249900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="536" mass="59090" checksum="99D893541FF0058D" modified="2025-10-08" version="1">MPDPAPFWLCHECGAQMRPVTVDGTPRCASCDGEFIEILDPEINPDPDYGLPPPPPTRPGQQIPSRSDPHLFNFPYPQPEGSSSPGSQRDTNNAGNFLSNLFSMLGTGTRPGNEETPRRPPPAFPGEPSTSQRNGQTRNTDRPGVRTYSFNFGNARGSVTVGTFGANFGRQGDQPSRMNNTSTSPFGNAFNDPDPFRADPFDVRFRRPGDGDRNDNGDTPLPLGASEALQLIAAILDGNPHPNVGNLGDFATSDADFMRILQETFMEAAGPQGPVPANETVIEGLPRFTFDKDYSAKSQFRDCPVCKDDFEIGNEVMLIPCGHIYHPDCLIPWLRQSGTCPVCRFSLVSEDRQPNNQRTPNDETEHTRNAEEERHATPTIPAAVSNFFRNLFGGSEPQPSNPATAAEGGQGSNASQDPHSSVNVVSQPTIPSDVSSRHSPTAMPGALQREQVQQHDEVTSEGSSNDTLIRVLPEHLDENHEDDAIDEEARRIAEQEQQAASRDRLADRVNRDFNERWQRLRREREEDDTVYHPDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSI9</accession>
    <name>A0ABR3BSI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613798.1">
        <property type="nucleotide sequence ID" value="XM_066758396.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990771"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50838">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="382" mass="43308" checksum="2A536FF504A94729" modified="2025-10-08" version="1">MAPRRQPQGSQRKGKQPAHETQDDSDEETQGGRSGSLTREYIQSRAGMLVRLALFQEYKRIPIRRTEIVKQILPDNTRAFPRVFACAQTILRFVFGCELYEIRARGKEESTEDPSQTQKKRKGKEKQSNRKTDAVEEEEEDEDEDEEEEDATATQRVKRETGTKVYILQNILPGEIIQAMSEPTPLPYGIQAEGDDDDSGALLQWDKGDGGIIGHVGLLGIRTLILSLVLCHNRIIGDDHLHALLRRLNLYRETVLPYASKDASDPFLTLDKYLDLLAKYQYLEKIKNPGPIGQPEGGTIEWRWGSREAEFSSIAAAKFMEEIMLGKEGESDSEEEEEDEEDQPRRRGRGAPRERSSRTAKRQKLRDDIIKATGGVPLNGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSM5</accession>
    <name>A0ABR3BSM5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614142.1">
        <property type="nucleotide sequence ID" value="XM_066757758.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990114"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="187"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="429"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0249955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="499" mass="54881" checksum="47F87BED6F17CD3E" modified="2025-10-08" version="1">MTSGAASQDTWVFDSGKGVFYHAPSNTYAVPDSFTGQWTYHTASEFHQASSSNVHQKSLEGPLNRTTMKSDGGRESEEEGEIQDDVGWGGLMEPEKLAEVEKAAKKWGKRNGERGTGEFRQCWTAAEAVSSYRGANSPLPPDISVSDSELPAEPSDYTLLRLVVISTKSPKVSTGQIAVIDTREGGVQIGRDKCEKGAPARIRLREMEVSKTHALIYWRENGDQQIEVEEDSKKNGEGWWIVDLGSTHGTFVSRPDASDQDGSKDAGSPAQKRLSNPKHSSKPFPLFHLSVFVIGSTTFQAHIHASWPCDTCQLKGGNELLLDTGETFVNNTKEAAGHGGKVWDFAMNSQQRRGNREAKRKLEMANLKESLLNRGGSEEGSASAQSMPSRGYIDRSAMRRELHRPSPPRDGHARFIAHTDPQVEIAPVENKFAEDFLGRQGWQRGEGLGKDGKGRADPIMTQTRVRKRGIGAEGCIDDGEDWRTKGKLRRWGDVGGQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSM7</accession>
    <name>A0ABR3BSM7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Superoxide dismutase 1 copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_103263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614147.1">
        <property type="nucleotide sequence ID" value="XM_066757763.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990119"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22814">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="5">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0249960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="298" mass="31647" checksum="FFD16B72F6C23DE4" modified="2025-10-08" version="1">MTLATASFKTEFAVDMTCQNCVNAVSGALRDVQGVERYDIDLENKRVTIIGKTPPSRLLTALKSTNRQVIVRGTSSSANANFPIQAAVAIMESPLPLPVSLASTSNPVLAGLPGGSPKPLPGMNEEEHSQKVFGICRFVQIAPKTVLMDLTVRLPPPSRVGLGTAQGAQDTKYNVYIASTGNLVNPPVTTGKPYFSLGSIAPDKDGYGDMFKEVDGELWEWIGRGCVVQAASEAAPTITQLVAKEAVPGSEQNEATIGRIFAGVVARSAGAWGNDKTVCACSGRTMWEEGREMEGKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSV8</accession>
    <name>A0ABR3BSV8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 130</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614224.1">
        <property type="nucleotide sequence ID" value="XM_066757840.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990197"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40894" checksum="8F4B8421EC79327C" modified="2025-10-08" version="1">MQGFNRYIPPDYDPKRASTLNLHQGKKHALGKRAKDIDKGILVVRFELPFNIWCGTCGAHIGAGVRYNAQKRKVGNYYSTPIFAFRCKCHLCSGWFEIRTDPKNAAYVVEEGAKKKDEDWNPEEHGGFKIHDTEAPSASETATVDPIAHLEKTIDQQEWAKKGTSRLTELTRQSARLSADPYAVSATLRKKFREEKKVMLEKQDRDDAVKERYGLGEEIDLGDETVACGREEWKAGRADKELHILGSSSLPSVGLPFSVKGVDYSTGQQKGNGKGRLSDSPAHLAEVLRKSTAKKYNPFNSPVIGFGSSSPSSTLLKPQHSKLEVLGSRGRMKEMAISKRKKSVEGRVVSVADDSSGNVSFGLLSGYESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT32</accession>
    <name>A0ABR3BT32_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614300.1">
        <property type="nucleotide sequence ID" value="XM_066757916.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990276"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="366" mass="41552" checksum="766576D0C75DF8B1" modified="2025-10-08" version="1">MSDLELPLPLDIRDVAGKGFLLPTARNIEPTGPKHLPKVIHPLHPCRHPDDILLITGDNVGFYVSPALITRHCGFFEGYESLKKEITGKEESSPMESGGKEGCHTERRELPSAKSSGLHLVLDNLRVIGSMTLVAEASPSTVKNLAMSAALDIQAFNDRWPLDAIFQNLAPALQLADAYDIPKFIGYMGLILPKDPWHRYLISALSNNEIFAKEISRETVKYHISDMPPLVVSLLYKNAPSYLWRLRKLHTEKMESYPGLKMAWRCAFPMYDKNEDFGHRCQKGKFGVPLCIPHGDFKGDFGRLRATAADRAFGILKREKSDEEVKEAIKDDLECWISCHRCRRRLVKTFLIIWDNWVSQWRAQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT47</accession>
    <name>A0ABR3BT47_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613809.1">
        <property type="nucleotide sequence ID" value="XM_066758407.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990782"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046813959" evidence="1">
        <location>
            <begin position="17"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="374" mass="38750" checksum="210CC5B314863A9F" modified="2025-10-08" version="1">MKYALFALALAGAVSAQSNSTSNSTESILIPTNITSSCSSFLSELNSDSTLSSCVAPLINATASFSPIAVASTNLTGDTINYTLASICKGKGGCDDATIRKWLGKFYSECYSELTSSTGYNSHVRELYDILYVVNPLKDAVCAVDSSNQEYCVNEIVQSESISNSNSTSNSTASNSTSADDASVALNATTLFANFAAVGSGLSPVEIAASSLYVEITSSASSLKKRFLDTVLSRRAAQSVHMATVITPNVTTYKNTNLPFLFLQPSMGSSALCTPCTREILVAYIKWETQMPYALGLKQSPILGGQSALWSAINSTCGTTYVNAINSEVGSALSSGLNGSSSGAESLLVGQGGLKGLTAIVGATVVAGVMGLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BT84</accession>
    <name>A0ABR3BT84_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614339.1">
        <property type="nucleotide sequence ID" value="XM_066757955.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990316"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="167" mass="18249" checksum="B31A4F209B644F63" modified="2025-10-08" version="1">MSVTLHTNLGDIKIEVFCESVPRTAENFLALCASGQYNGTLFHRNIRGFMIQGGDPTGTGKGGQSIWGRPFSDEIRQTLRFSNRGMVAMANAGPDTNKSQFFITYAKQQSLDGKYSIFGKVIDGLETLDSMEKTPVNPKNRPLQEIKLLNVTIHANPIADQAKGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTA6</accession>
    <name>A0ABR3BTA6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Topoisomerase 1-associated factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613854.1">
        <property type="nucleotide sequence ID" value="XM_066758452.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990827"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="6">
        <location>
            <begin position="58"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="570"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="941"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1040"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1104"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="953"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="978"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1051"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1078"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1126"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1137"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1188" mass="135552" checksum="A4A7FC55883AC756" modified="2025-10-08" version="1">MDLPDSPPPLDAPSPPHFLDAPQDRWNVFYPAVQTLVNALGGYEEVESPPDSGIFETVYRPGDSVLGVLKDLKKLWRKDDEDDERTVARCMHKAELMKELVAILVECAERGEWGRKVALVACDLIAALTWPIDVAQELKEIEDEGPVVTDYASLLRAQLEYKALFLKTTKPLKSILSLMVPCLAKSRKDEKDSRIISLGLHVVRNLLAIKDAVAEGTATGEKEEFAHLQSDLITQLDSLTYLQLFLSLCSCADKTDLNPFNVILLDILHLIFRGIRPTELAQDQERIPIDSLAKLLEKEKKQKALNSRVGSTRHSRFGTTITVKTAEQRVVLHRQTAIIENPGKILDMTKKKKAVAAKSMDDLTVYVNLSSNAMVVLQSFSKSFLEISYNTFIESILRDIRIERTKIRPSDNIRVFYLSSFFIEYLLLLRHKLVEKGDSRRLEELPLGLVAQIAEMDSVKWLFARLRICWDDKPKAWTELQACIECFTQILLLIDDMSTSTNEEDFEVAEILQHQLYYNYDILDSALAVVREYKNQSVAYLDSVIHFAYVLLRMLEKYSKTKAFMFIRKRKNKHKKRKERQAASQANADREQQGESRRIPEEYGDEEEEAFAPDQDAPSYAEHAFTFQSFEKRFAQEAVVNTLLTYLERFLEFDGPEPMRRVVGLMHRQVVKAHAESLYFKVSTLIVFRRILDKKHALPAGPSSRDLITLITYILRKFFKHVAKEPFTLVEALSSKSRGKWKAIREGGSDDDDDGMAGQRGRIKEKIGPVELQFIKKHKFSWSQQMSIAFAIIWGDGHGYLIRWIVEVLEQVLAAKQEIVLTTDGGINGDEDEEDEDGNVRVRRFGRPSDEAISKFTHFDLQPEGNEQIEAVTSNPHFRLMLKLLSFDLPPPPTELDFVEDITSEELALAREKSDSAWFLPANVLPSNIEASIGALKQYMEEPPTLDDDPRKLLRRKTRAARRRRRSPSIESYDSETGETRPDRPHKENSHQKRAKKAVETQNYKSAAFIEDSDDEDPEATRRFFENEERLRREMDELAAQGGHAMMERGVKRKRGKKKGGKDPNDVSVPSLTADISGSEDENTLEGDVEDQDEVFRITTITAEQKAQMERQKAQLTAIREMANGSDDEDGSDDDSELRAKRRAMESSESRMPFFEGSDNGDEDDEPFSKPSAKVRRRVIDPDEDDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTE9</accession>
    <name>A0ABR3BTE9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_102397</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614411.1">
        <property type="nucleotide sequence ID" value="XM_066756942.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989254"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="154"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="433"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="433"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0250224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="554" mass="61727" checksum="733624D754F7F941" modified="2025-10-08" version="1">MSTNHAEEYELPELPPSPEAGSSRRPRPQRRRASTSTKSRTVTLHPTTSTANLLFSAPSGAFPSTRQRHGRTRSQSNIDQSEVPRVHRATFLSEDPYDDSEEVDLPDFGHMLGINDEGEDHFAVASGMQTRWKRKLYLLMEEPASSREAFFVHIMVTGAIIFSAILTTLSTMPAFHMEPIMTKTLFGLDTTIVVLFTIEYLARSLAHSDSWAQYYSWATSFFGLLDLLAILPYYIEVAQNEDTTILFRFSILRTFRLLRVFRAFKHQNQMLLTIEVMYVAVRRSKDALWALTFFIILVLVLFSTLIYFAERGTWDPSLAAFIDADGDPSAFDSIPRTAWFSLVTMSTVGYGEVVPKSFLGKLLTIPLLMFGLLLIALPSFVLGRNFAIVFDAMTRQLPKNVSSSIPTPRASIEQPTITPVSTDNIPLLPLSSQDAQTAAPNGPSLSRPRSTSPFPGSGTANQRAAFGNAPRMWEGGIDGMGEAKKERDLTNTKLAKNQLVLLEQIDSLRQTIDKQGEMLARLTEILNVKNKGKGPEMSKGLQEDHFTLGDSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTH2</accession>
    <name>A0ABR3BTH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102424</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614438.1">
        <property type="nucleotide sequence ID" value="XM_066756969.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989281"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041177">
        <property type="entry name" value="GEN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="115"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="557"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="640"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="774"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="830"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="858"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="892" mass="97513" checksum="4010DAE710CEFDCB" modified="2025-10-08" version="1">MGVSGLWDLLRPSAASATLHTLSREAFLDNKNGLRALTIGIDASIWIFHAAVPQHGENPFLRTIFFKITALLQHPVLPVFVFDGPNKPAMKRNQKVGGKFGTHDYRSKQFKALLDTCGLEWWNAPGEAEAELAVMNRQGKIDAILSDDGDALLFGAKCLIRNSSPTLSGSLASSTKNNSSAGSKRDYDVYTLSRICEEWAKEQDTELTSEESCTIAMVWIALLSGGDYTPEGLYSIGHKISYGLAKIGLSDYLKEYSRDKQAFLKSLPELHARMVEELRTNSCKQQDKRYPDRSNKLSALSPSQLFPMSTLDAYLSPCTSPLDDASQGWPGFGQGSCSMTRGKARREGRGDMEGMAAACEKYFEWGTKDLVCKKFAGESVGVFGAEIMNAAREAVRARDSLSLGVGIGSEKTPSKITSFFQQSVSSPISSKSVGISRIPNPSSQQCDGIPAHIVLIHSERTSKDGTETDYRISFQQDEYVERCRNAMLGIRVDPSELPQEERDRLGLADHGDKDYDDKVSATQTASKSEIRVWLPQYLVRMAWPDLVKDYDDKLAAKTASKSKTPKKKAHPAKTNASGKAKKGRGKKALEADGEDVGAFTSFFSQRPKESSWLDAFDEEEEQIEPTPPRSMATQEIIDLSLSPSPSPSVSPTRRPANKAERKRLARPALNASTSSTPSNGEKGEDSSRTVRHTRKKIHKSSSPLTTIADLSKSSSPERSKAAPSVGPRFSNRTFRKTISSPSAFPPRQVQTQEVIDLCSSSEEDTPPAKPIHRTQVSRSPKISSTPSGILSGPSKANIKSPHSSRSTSVSFPASSSDKPSSRSPREGSILSHPLLSGSSQPSLSPPLPMSPNRQRSTSPKKVKASSPVRRRPKYKIISSTKDGEVIDCTMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU18</accession>
    <name>A0ABR3BU18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lysophospholipid acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102617</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614630.1">
        <property type="nucleotide sequence ID" value="XM_066757161.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989473"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="420"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0250443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57973" checksum="39215DB6099E40DB" modified="2025-10-08" version="1">MFWDPLFTAVSKVVGAPTDQLKLIFSLLVAFPLGSIFVRLPSAHPNVAHLFSIAISTVFLVPLLGLGGGMLHMLFSSLGTYVIVNSMRGKSMPWVVFAFVMGHLLFNLVAFLGYCFFFPSVLVGPSFDYATYDALIHKRLYSSPPPGSSPEQAKATKRRIPYGRKRVAYLHLVIGLFFLGVYALYGDKYSYENVLNPIWTGWGWTRKLSFVQLAGLLARTKYYAVWSLSEGACILTGIGFNGYDHKTGRTLWNRVRNINIKGIETAESFKILFDSWNCRTNVWLRDVVYKRVTKKGKKPGFKESMATFLTSAFWHGISPVAFFMGGLVTSLGRQFRRYVRPYFLPLSETAQPGLAKRVYDLIGWISVQSTLNYLVAPFLLLDFKDSIGAWNRMYWYGHVAVIISMCFMSFGGRKALKRGLDKRKSRIPPSVKVSPPSPPIDHTPPPPPEDEMDSTDLRWVKHDLDNPEDQDSGEGVAMGVAIRDHGFLDKWIEGEETPGSTPGGTPKYEKDDPLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU52</accession>
    <name>A0ABR3BU52_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ER to Golgi transport-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_102657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RER1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614666.1">
        <property type="nucleotide sequence ID" value="XM_066757197.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989513"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0250479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29283" checksum="BE78FDA05C6726B9" modified="2025-10-08" version="1">MNTYPAVNPYPPTQSTPSTGPGSGFPPKSGLAGMTPHSMSSTPVPNMAPGAGVRGGLPEERNVAQRVRENTNVWARKWQGLLDRSTPHVLERWLVTLGLFLLFALNVILRQGWYIVCYALAIYILNLFLAFLQPRFDPSLAEDLAADDVEEGAPGLPGAGPAKTQGGLKGLLNGFSSGEDDEEFRPFIRRLPEFKFWYSATKANAIALLCTITRATDVPVYWPILLVYFFTLFGLTMRRQIQHMIKYKYVPFDLGKKARYGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU56</accession>
    <name>A0ABR3BU56_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_102653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614662.1">
        <property type="nucleotide sequence ID" value="XM_066757193.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989509"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0250475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="103" mass="11007" checksum="4E839C586F43426D" modified="2025-10-08" version="1">MKYTIIAPLRPRLRRHCHAHYHRAILCSLVGDATPAALLTTNPLNSSDVYVTSNSFGIRAVGSAYPSQGIPNTSASVQGTGPQAGSGLALSSLQPLFYPMRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUV4</accession>
    <name>A0ABR3BUV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614907.1">
        <property type="nucleotide sequence ID" value="XM_066757438.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989759"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16612" checksum="66F4CDE3E4CF69C4" modified="2025-10-08" version="1">MSGQEQKNEPSQLNGQLNSASGFVQQAIGNVVPESMGASFWTQSGHKLQKEGQNEVDAAKAQKAGAATVDSGVGKIKSAFGYLTGDQDKQTEGNTQAEKAQWDYKQATSDSIAAIPIPSVEGVKGKLESIVGMTTEDPEKQKEGNIRAEKAAWKDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV85</accession>
    <name>A0ABR3BV85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calcium/proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_102985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614956.1">
        <property type="nucleotide sequence ID" value="XM_066757487.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989841"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="164"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="435"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="369"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="599" mass="63810" checksum="7E615EF1C28FA33A" modified="2025-10-08" version="1">MSRQNALHEEPSLTDSPLSSPALPDYGPHSSSTPITSNGSPEGTTNSDSTGPRRRQQPSRQVTLDANPPSATRRQTTESARTQRSRAGSRRTSDSLDPNTGLVRRVTTVLFTPPKKVGKAPTYWGSLKAAITSTWLNVLLVFIPIGWALYLAKHNGGKDSISDTAVFCCTFIAIIPLAGLLGFATEEAALRLGQTLGGLLNATLGNAVELIVAILALIKCELQVVQSSLVGSILSNILLVLGMCFFAGGVRFAEQAIKSTAAQLNASLLLIAVIAVLIPSAFHFSISSSTSNTDASELANGEGADLLSMSHAVSILLLILYLGYLVFQMWTHATYYVDDAVTGSTQYPEAVTNVSEKLKFRNFHRKKHDEEEGYSTATTVSDGTVPPSARAEGGEVPATHGPGTAAAETGDRVEHEGEEEEEEEETPQMNVVCTIALMVIDTVLVGVTAEFLVDSINGMVASNPSLSAEWVGLILLPIVGNAAEHFTAVSVSVKDKLDLSISVAVGSSIQIALFVIPVIELLAWTIGKPMTLLFDPYESIVLFLSVLIVNQTLADGRSNWMEGMVLMMLYIIIAVSFWYYPGSSTATLLGCKDSSSVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVK5</accession>
    <name>A0ABR3BVK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_103446</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614325.1">
        <property type="nucleotide sequence ID" value="XM_066757941.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990302"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="58"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0250138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="590" mass="64089" checksum="07C4C217FD691998" modified="2025-10-08" version="1">MGKITVAPSREEVPSLSALGIEAHPDALTLAYDDKALANSYGGNGLKDLLASRMVLLAASAATIGGLLFGFDQGILSISLTMPQFQEQFPETNAQVNSSASLNKGVMTALLELGAFLGAFMSGYVSDRYSRKGSLAFGMVWFVIGSVLQSASFSFAQLVVGRFIGGIGIGVLSSTAPTYISEIAPPNIRGALLVLEQFSIVLGVVVMYYITYGSRHLSGDGSFRLPFALQMFPCIILGGFLYYLPYSPRWLALRGRDKDCLASLCRLRGLPNTDPRVQAEWINIRAEAIRNREVLVKAHPGMTDQSTKSEFKLELASWVDMFRSGVIRQTMIGILLMFFQQFVGINALVYYAPTLFEQLGLDYELQLHLAGALNIAQLVAVVIAFFLLDKIGRKVFLIVGALGLTVSHVVVAAMIGSYSDNWPAHKGPAWVGVGFIFGVMIFYGIGWGPVPWAMPAEIHASSRRAKGVAITTCSNWLNNFIIGLITPPLVSGTKGYGAFIFFAIWSILAGVWSVFFVPETKGRTLEQMDAVFKSHTAIEDAQARDDILQIICKEALNSTNNPGQVPKMEVEMVENVDEKKSGTPSTISKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVL3</accession>
    <name>A0ABR3BVL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615130.1">
        <property type="nucleotide sequence ID" value="XM_066756353.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988659"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="1">
        <location>
            <begin position="52"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="1">
        <location>
            <begin position="170"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="382" mass="41935" checksum="0BCE9B4E758FDA76" modified="2025-10-08" version="1">MIMAEASSSASAIHTKQYKSYFSPANVERLSAKQRGKLSVSREERVRQQACGFIDAVGVRCGFPRRTIATAQTLYMRFHLFFPYKDFSYIEVALATLYVSSKLHDTLKKPRDIILASFPIRFPHLLRKGTVDPSVAQAHGLDSERARVLSIERLVLESMAFKFSANDGLRPVIKIGKKLGVNKDFCKLSWKVAVDSYRTPAPLSYPPHIIALGSIYTAALLTMESLSPQIADSVDETGTSKRIVELLGNTGSWEIDYVAGVTHVDEVVHALLDLYHTVLSNPENQALHTPSPVSPKEPLGSAASTLAFSSSGATAFPLSAFWTPQTLTKLKISLRERRGGVTAMPGWATEDAGETDKVAEGMGKNDVTIRFLWDEDLVAMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWE8</accession>
    <name>A0ABR3BWE8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="9">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA4</name>
        <name evidence="12" type="ORF">I308_102095</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="9"/>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615423.1">
        <property type="nucleotide sequence ID" value="XM_066756646.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988953"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0274">FAD</keyword>
    <keyword evidence="2 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="11">
        <location>
            <begin position="8"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0252703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="505" mass="56774" checksum="C19CB999A05FF0E8" modified="2025-10-08" version="1">MPQSRARKALIVGAGPVGALTALSLHRRGWEVEVWESRDDPRCQDAAPSNLRSINLAISSRGLEALRSVDPSIAENFLEEAIPMKGRMIHHTDGRQESQLYDPIGGQSINSISRPILNQRLVQSLPQEIKLRFNTKLNRIDFKNRVAYASHKQANVMPGEENVEDKKQNTENEDGTAFDLVIGCDGSWSKVRNAMMRVERIDFSQSFIPHAYIELHMPSNPAFQGGYAMNKNHLHIWPRHAFMLIGLPNKDGSFTLTLFIPFSSLELLTTRESAAAFFKENFPSAVEIVGEKVLLDDFEKNPRGNLVTINCTPSAWSSHAILLGDASHSMVPFYGQGLNCGLEDVRVLNSILERHHISPTTTRALGETDPELELALKAYSDERQGDLKAICELALQNYTEMRSHVLSPLHHLRRQVDKIMTTLFRSTPQATLSLTDPFPTKRVRGWTSLYEMVTFRPDVGYSEALRKERWQKDVVGYTGWIGSVIGISAAGVFAVTMAKKWLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWJ3</accession>
    <name>A0ABR3BWJ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615478.1">
        <property type="nucleotide sequence ID" value="XM_066756701.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989008"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0252758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="424" mass="46168" checksum="25982D7C8AC0C507" modified="2025-10-08" version="1">MPIASSKPSAEVTLDVGGQANVDQLHRVSRDFRSDTITIPTDAQLLCSLKATRGDDVYGEDPSTAALEKRIAKLTGKEAAMFAVSGTMTNQLAIRTHMKQPPHSVITDWRAHVHKMEAGGIAMFSQATTHQIVPENGLHLTVEDIEPALQLGTNIHIAPTKLICLENTLSGMIFPQEEIVKIGEMARKHGIGMHLDGARIWNVAADVIARRGLNPNKEGDLQTVLTELIAPFDSASLCLSKGLGAPIGSALVGTKEFIDRAKWFRKAFGGGIRQAGGIAASADYAITHHFPRLVKTHELASRLEQGLRELGCDILAPVDTNMVFFQPKPIGLPLDAVMARLAALPDPIIIGRERCVVHHQICPQAIEDFIGCITEMKKEKEENGECKVTTLGQEEKDKLYRFVGPETNDETSEAELRKKAALGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWN5</accession>
    <name>A0ABR3BWN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_102184</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615512.1">
        <property type="nucleotide sequence ID" value="XM_066756735.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989042"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="75"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0252792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="190" mass="21975" checksum="EB74512E62C6B62E" modified="2025-10-08" version="1">MALPKTLHPALTPDELTFLAENDHINIVPLFSMTRVRLISGIYGPFRPPSASRVPLWLGLSLKKKRKCRVVPPEWLSVERLQSFLKDEKENSEGFERLPRRFMEISKILLDIASDDLSQPTLLRSLLKDIREVRQAKIRMGLQSEDVLQNDYLQVTNLTPLELCELKPFLVRAMGLMQTLRPPEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BX31</accession>
    <name>A0ABR3BX31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615155.1">
        <property type="nucleotide sequence ID" value="XM_066756378.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988685"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0252435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="123" mass="14040" checksum="E4F3FA13FB7111BA" modified="2025-10-08" version="1">MIGVDSNSGYRFVSQWQHYESHMIVFKTRHWPPKPGSPSMSPQQHPFAILTFSLTLDLLVHGRQSDTKKHGGDGQRGVVFTRIERCLVSGAKKIKPQAINTLVVRSMYHFCKVDELPALWAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYT1</accession>
    <name>A0ABR3BYT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_100921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615769.1">
        <property type="nucleotide sequence ID" value="XM_066755483.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987779"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0253548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="87" mass="9659" checksum="3232BA838277D675" modified="2025-10-08" version="1">MIALRAATSARVVVSRAPASMFVRHYAPDVRSEGATASSTSFHEREQAKESQYVRQREAEKLKEAKAKLAEAQAEVDKQQKVVDAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYV1</accession>
    <name>A0ABR3BYV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615795.1">
        <property type="nucleotide sequence ID" value="XM_066755509.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987805"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="711" mass="75451" checksum="52068D9A38F547E9" modified="2025-10-08" version="1">MELRPVNPADDSSAQQVFPLRSDMSGEIMPPPNLVPATVETIEAGTSSDAKQFTYPSEIGTFTPSNGNPDTSILVPFTESNNTPTTDTTSSSKTLPSSSLPPHLRPASDGSYSSPAPFAPHYVQGSFPNNDSHPSHVSSTEVSSNRPLFSPTQLQSSVLPDSSAELPTKKVKTYGKSSHAAPLSPINRFDDGLAAPTGISSSPHASRPQDRGKPTIFSSDGEDGGPFTRLGGSAPGASGSAGLRRSSQSPLKHANLTSPDPLDSLAKKRKLLAASRAVVEVSLPDHMSPTKKASVVPKRDKDDEIRKRKRAESGGSEKPASRGKEVEQPQVASEEELLQSSPPHVDLPVETSTLLHAPVNPQASQVSSFSAQSSTLSNTISTSTSEPAPKPKSKKRRFDPMEIPDVDDGVDEDFQPRTRKVKPKPKAKTKPKETKEKNEKKAPAKKGKKAFSSAEVGEEPENLPATGDSAPHDTEQSIVTSNVVEVVEPASTPAPATERTPQLQSLPEPQLPTDPQPALEPIAAAPEPKKTKVSKQKASSKKKATQQPTKVADKENSKSPSKSPAKSPTKPANPLAQPSSSTDTAKSPTPPRQPLARASSNTSISTPQSLSSSSRPMASGGREGTPVDVKFRNPRKDLPSVLAKFGGHKPTGMSKKLKIVSLHSKIGPPAKALPPVPKKPQKKVESEDDDDDVDGEKKVKPGSKEWLMMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYW6</accession>
    <name>A0ABR3BYW6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_100938</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615786.1">
        <property type="nucleotide sequence ID" value="XM_066755500.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987796"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="114"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="12">
        <location>
            <begin position="497"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0253565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="565" mass="62548" checksum="46A226BB6DCEAEF5" modified="2025-10-08" version="1">MAFRQLARAQPLLARQAIAPRAYALLPRALPAQAASFSSTTRRANIPPPNELPKGAEFVQPKPYVLTRGRKFLQTFGRVTLIAILTATGAFLYVTYTQSNPAEQLDSDPSKPTLVVLGSGWGATSFLKSLDTDEFNVVVVSPRNYFLFTPLLPSVTVGTLEARSIIQPTRYITRHKKRKVSVYEAEAQEVDPVKKTVTFEDISDIKGKASTVTIPYDYLVYAVGCENQTFGIKGVPEYACFLKELSDADKIRTKVMDCIETAAFKDQPQDEIDRLMHMVVVGGGPTGVEYAGELHDFLIDDLKKWYPEIADRLKITLIEALPNVLPAFSKQLIEYTESTFKENKIDVLTRTMVKDVKPQSVVVQDANKEIREIPYGLLVWATGNTSRNITRDLMTKLSHVQTQRRGLLVDDNLALLGAEGVYAVGDCTATSYAPTAQVASQQGIYLASIFQKLGQKAKLEKQLAALRADPTADASEIESLTKKINRASKITPFHYSHQGSLAYIGSEKAIADLRLFNGNVASGGSAAMLFWRSAYVSTLYSVRNRTLVLTDWVKVKLFGRDVSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYY4</accession>
    <name>A0ABR3BYY4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VanZ-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615819.1">
        <property type="nucleotide sequence ID" value="XM_066755533.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987830"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30175" checksum="5EF3F2B92CC7D838" modified="2025-10-08" version="1">MPTAYPVPTQMLQQLWDRFTAWVMRSYPIRDSPLNIRPAMVFATALWVIMLGILGMAPLPELPVNDKALHFFGMGFATFLIYFAIEAPEGPGRRVWYIRQAPLILTLFLSFFVGGVISEFVQATLPWKTFQSLDILSNLFGSSVFLYLAHLAHKRHLRKQEISSLYEPLSAGGVGRYRDAQGREHAFDMPSSSGGGSSSGGGVRTPRGVSYANAGAGGDGWRGQRGTGAIWDEESESESVGGGSAETERAGGQGWVPAPVFKIDDDDEETQGRVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ27</accession>
    <name>A0ABR3BZ27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615476.1">
        <property type="nucleotide sequence ID" value="XM_066756699.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989006"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="56852" checksum="7B86E04AAD2BE046" modified="2025-10-08" version="1">MSEVDVIIIPTFPPSPPTTSSSRVISTSPEWFSTPTKRPYKPSPLSISIPINPLAVIGSESDPNMNEEDGPLSSEPCTPPLSPSDTVSSVGMTREVSSSSTSSSGSEGDSEDVIVTPSPRRPSYQRRTSPSSYFSLDPRRTKKGSRSRSLGVPLSGLIEPMWKLEEKEKSDVNVKSTGANRLLEPFKMTLPTKKATDIRYVLDENSFVLAHVPTKIVSLSAFKPRLPRVPRWQRPIVIAVMSVLLFGSLCMVSWFQQSLINAERSIAVRQGEWMVKYAAMAKAESNEMVDTEPGYKPAKPQHHPLKGQWKLSKRVGDDQKPFKEINLHMTKDEELAALMSFIVGTTANTLPPIDPENALSLEGFLPFNPRSPHAKAELEELVRTQWEVNPIMILGNMRDPMMREARALFKRYNVKPAPFYVDIDQRPDSAYLSATLEHILGKQTGPYVLLAGKNIGSTSKLLELETKEALISTVKNTGASIAKKLKRNKHQKEEERKENQRVLGPKRIEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZH3</accession>
    <name>A0ABR3BZH3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_101156</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616001.1">
        <property type="nucleotide sequence ID" value="XM_066755715.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988014"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="317"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="390"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0253780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="551" mass="60396" checksum="AAC17D627B87C342" modified="2025-10-08" version="1">MAHSPPTQADLDILSLLTSDQSALGTRSFQSARLKPAPQPVSGKKKSTPRRDSPLDALMISAVLAGSGPITRHHFGHGLAKPGSYSTCDESRPSSPAAPRVIMKSTQAPRSERLRMEHEARAAFEKGAVDRKILEDQSDMTKIESQQAQATYDRAGKALSPPTSLVKDPSKRRMSIDPVPLTQTLRRASASSFNFFHPHVNAAPQAIPGRIQVRCMARTRIPSPHGELFLHLYHNSHDAKEHLAILLDPIQLDADVRAAAPNSRKEIRSKSLDAVWRDGETEMERIVRGAYTGRLKAGATVSDNGEPVPSGIVGVEDIKPLVRIHSECFTGETIGSMRCDCGEQLDEAIHQIAESQRIPVPLVTPNSYPANSPSTSATFHPESTAYTHVPGRGVVIYLRQEGRGIGLLEKIRAYNLQDLGHDTVTANLMLGHGADERKYDIAAEILRDLGLAEEGIRLLTNNPEKVRGLASEGIKVVERVGMTPRSWQCGDDHSLENKDGTEEEKEYEDWRMRRAGVGLIGAGMASGPELEKYLRTKVERMGHIIDIPKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZN4</accession>
    <name>A0ABR3BZN4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616069.1">
        <property type="nucleotide sequence ID" value="XM_066755783.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988084"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="205"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0253848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="443" mass="48680" checksum="30623308C57001BD" modified="2025-10-08" version="1">MADCITIAPELSFKDQITELAAHLSRSLPNADNQVAVKEFVQGYENQVATEEGKDDVEDAKKKQVVKSIVDKFVELKGGLEAAKESEVESSHFLLQHVLSTTFDQASEEYAQAVKDVNEAVKKGAQETTKITRAEAASRVLKNTYNFLPSNSPIRPSTLLALMSLLASTLDLSALPLSTSTLLPALSSWSIPSSEKVSFLTTASGLYQSTGNLAKALELLTLALKESVEPTVVEKAVLLALAVPNRFELDDVLAVQGVKEQLGEVQGVAELFEGDEVEAIEKGKKWAAENVSLIEGAGIPGFTSETILRKLRLIALVALCAKSETRQLEYAPIAKALAIEESEVETWVIDAVRSKLIVARISQPQSLIRIQSISSVTESSRRFGPNEWQLLEKRLEQWKKSVNEARQVVEEAELVAQQGLGQQRRGGKRREEKKEKEEKEEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZT0</accession>
    <name>A0ABR3BZT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616058.1">
        <property type="nucleotide sequence ID" value="XM_066755772.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988073"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0253837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="962" mass="98314" checksum="B9CDC6508D16EC27" modified="2025-10-08" version="1">MAHRKRERKMLEELSGGLETRSRGISSHPSFALVSFSFLLLSLCLSPYPGVQLTSGHTRRTVQYTAPKKRSSASFVTTHAMSHNASGGWGASGGGFNQLQQPAQGEDDDPAPKSAPSPIADISKPAPATKPTPAPVQDESVKADASETRDPEDASVTSVSVPPSDIDADAGEIQDDNAGGWGDEPVKTSADNEGDWASPNTGNDTSNGWDGPQRVRTGVNDGRKKQPESEPQQDNSGGWGAEPATLKTGNNDDDAGGWGSEEPQQANGGWDAPPPAPSSNDNAGGWGEPQPPVRAPRSQTSNSGGWGSQSQLAITATPVPPAVRPARQSAPPSQSQSINYGYGGGRDASDVGVYIPDAVVSRGPWDKPFVCPQSDNGWAGFAARRRGGAAGASISAAAASGWNAEPAQQSSGGWGAEPAQTFSNGADDGGWGVDPASIKSTPSSASVPIPAPAPAQAQAQAQEDDNAGGWGSPEPAQRTPKAKAKVVDDAGGWGAEPAPAPVQTNQVQSNDDAGGWDSEPASSGTGDAGGWGDASESQSQSNSDSGGWGGDTQSQSQSQSQNGGGWGDEPAPSGGNNWGSRSGGGASHQPSESGFGGSLQGDDGGGGSEPEKHSSAPAPTAPVQEPASADDDHGGWGGETEKIEPEEDDGGWGGEPEKVEAPVAPTPAPVEEPKVEPEDGGWGGEPEKVEQPQEKPSTEAEQPESKDDKESKPASKTEVNHASDSKPTPIAGPVKAESVSSKQGSEHNTPKSVASSIREPSAPPSQGASSPRPFAQPFTPRTVQNSLLFASPVQRHISPAPLIVSAGYLDGRVSPFTPGYISPLAAPGPYSIAAAPIGVPPVPDYSAPVPVIPAVSPPIQPSGPRYFEPAKSDSRVSIKTPNGAPVISPAGSNASLPTSPTVAPVAQSGYYEVPHVPVGQEGGYYQPMNPYDSMPSHVNVPVAVAGQGMSGFVERYRCVGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0E6</accession>
    <name>A0ABR3C0E6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydroorotase</fullName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615841.1">
        <property type="nucleotide sequence ID" value="XM_066755555.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987853"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01294">
        <property type="entry name" value="DHOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="75"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0253620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="353" mass="38411" checksum="98F5CB20CBAE51A6" modified="2025-10-08" version="1">MPQEIVLSSPADFHVHVRQGKMCELVTPQVAKGGVRTAYVMPNLVPPLTSTDAVVSYKADLEKIDPSVQWLMTLYLHPDVTPAEIRKAAKAGIKGVKSYPRGVTTNSSSGIEDYEVYYPVFKAMEEEGMVLNLHGEVPSDADKNISILNAEVHFLEHLRKLATAFPKLRIVLEHATTSAAVEAVVSLPSNVACTITAHHLYLTIDEVAPQPHHFCKPLAKEPKDRKALQDAIKSGNEKFFLGSDSAPHPLSSKAPALTDEGAVSACAAGVYTSPILIPLVATLLESFGALDKLEGFVSGHGRNFYGEPAMKGQELTLRRTKENEGFVKGTFRGDGVEVMPFWTGKRLGWEIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0Q8</accession>
    <name>A0ABR3C0Q8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616429.1">
        <property type="nucleotide sequence ID" value="XM_066756143.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988446"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0254208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="137" mass="15173" checksum="18E0F1F15E8F970D" modified="2025-10-08" version="1">MPVTLTGGCSCTALTYRVSLDSLDDARVTLCHCSSCKKAFGGDFGLTAKIPVSSFRYTQGQATEHKTKNGVKREFCSICGSYILEYGEAAANDFRYIVVGSLDEPAVLPPKGEFFCRNRLDWMPQIPNTFQKQEIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0U1</accession>
    <name>A0ABR3C0U1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid/metabolite permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_101161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616006.1">
        <property type="nucleotide sequence ID" value="XM_066755720.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988019"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF9">
        <property type="entry name" value="AMINO-ACID PERMEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="716"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="721"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0253785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="757" mass="81496" checksum="4FA03ADF07A89B82" modified="2025-10-08" version="1">MAMSKRPPLPSVAASQDDTAYLKSSTSFKIPATPYNSCSDLDASDNPSIPLSHSSTRNLSDAVHDSPLGSDLHIPLSGDTPSSSIRRISVSSHSSSYLLPNPTLSMTKPHDIPYSSRPIPAPPVTIHHDQISNQPSRKISGDAASPVTELSQLSSPPGVKFGMDLRQNESRGSASQEDVDAQRLRALGYNAVLGRDYTFWSSLAISWLNIGALQGTIFAVSGTYNYGGPVMILVAWPISGVLTYFMTLTLSELASAYPVAGAMFSWSWKAARGGIGGERGWAWIVSGFVMGGHVGNLLLVTWEIANIVVGTIGLSLNYQEKNWHNFLLFLGILVIVGLIGSTGWGQSHCFWLCSGAFGFSMWLVLCITLLATNATKHDPGDMFNQFYNTTGWSSKPYVYILGWQYTTIASGADASAHMAEETQNPSRNVPNAMTTSVIATYVLGYISIVLLLLSISPEDAATVKSHSFAFGYILTKAISKPGAITICCLMVVVLMLQVLAQLQASSRFVFALARENGMPFSSIIRKTNNHRRPVFAVWLVVILCLPFACLTLASESTLYSVLAVTACTLSYVGYAIPISLYLVSRINLQTEGRSLWSLRKWSKPVAIIGLLYALALIVTQTFPGSTPVKASTMSWSPVIIAGTGVMCYVTWKCYGDKHFAGPIRAITKWESGMEIDLSTTLASSRSRHSGFPQDQATNDSLKLALSPYYPSGIEGPGADVTVQSAAGSGITSEGEWTSASESDNTISAWTQTGGENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1J2</accession>
    <name>A0ABR3C1J2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_101404</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616246.1">
        <property type="nucleotide sequence ID" value="XM_066755960.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988262"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045324467" description="GPI mannosyltransferase 1" evidence="14">
        <location>
            <begin position="30"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0254025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="423" mass="47491" checksum="B6A2D207576794C5" modified="2025-10-08" version="1">MLRAKTSQIILVSLALHLALILYADHVDSHPERYGGLRYTDVDWRVVTDGARLIFNPSEEEQAKGWLVKKTGFPIGDPYSRATFRYTPLLPLFLSPALIHPLLGKCLLALPSLLIPLLLLSGPDPAPFWPTHLLWTINPLVLSITTRGSPEAAICFFVIALHYFLRLGSEDKKKGVGETRAAIMLALAVSWKIYPAIYIPAVWKELSTRWGWFGARVWRFGFIAASSFVLINGILWSIWGHPFLDHTYLYHLSRLDHRHNFSPYFYPIYLSFFPSPSASPLPSALLAVIRHPLTSFLPQLTVILITSLSISSLGFAMFLQTALFVAFNKVCTSQYFTWFLPLLPPVIPQLHLSRRKTVMLVIAWILAQGVWLGSAYLLELKAQSVYIVVWAAGLLVFGVSIYVLGNLIDGWAPPARTTKGKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C1S0</accession>
    <name>A0ABR3C1S0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import receptor subunit TOM40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_101479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616321.1">
        <property type="nucleotide sequence ID" value="XM_066756035.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988337"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0254100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="40637" checksum="C33CD96C7C157CEF" modified="2025-10-08" version="1">MSTSTEKPAGPSAFTPYLDAVANVFHPVSGPVLNTYARFHGWKENMGLVQPGTVENLTRDVQQVQLANWMFDGARADVAKVISGNPAFQLTHSFSLGSTTRPAAYNFGVIFANAKTFLQGGLDGTGSLTMRANQTWSARDLSKIQAQITDKPGHTMVQFEHDHIGDHYTFSWKSINPNLLDFTGIHMASLLHSVSPRLSLGFETVIQHPEPAILQTATSYVAKLTSLPNAVAALTPTAPGVPSPFVPSWTATGHLQPDGNIQATYYQKLSDKVDVALDFQTILRPQSMLGPAKREALTTLGAKYDFRMATFRGQIDSAGKVGMYLEQRFTPAFAFLVAGEIDHAKNASKFGVGIMIESSTMTQEEMIAAGMLTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3E2</accession>
    <name>A0ABR3C3E2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616255.1">
        <property type="nucleotide sequence ID" value="XM_066755969.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988271"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0254034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="379" mass="39668" checksum="1A3C1BDA1F478F0B" modified="2025-10-08" version="1">MSPPSSPRNIVVIGGGIAGVSTAYFLSTHPRRSPSTTITIVEGTKIAAAASGFSGGFLAKDWHGSSTASLSEFSYDLHASLAEEFGGKEKWGYRTVETLSIETDATSMSKKESPLHWLPKGLVHSSRILGSHTTTAQVHPRLFTTFFSDKFLEQPSTSVVIGTVKSLNIEDGASKSIGVVSPEGEKTEIEADVVVIAAGPWTGGLAGQLLGEKIGSRLGVQGHRAHSIILKTKEELSATCLFTSMTLEDGSMGEPEVYARPDGTTYICGAGDGVPLPPSAADVSPSKSALAKLHKQSQSLSPIFTVEKGAEVISEQACYLPIADRGRPLIGKVRGVEGIYVGSGLSCWGITQGPGTGKVLSEMILEGKARSADVSKLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C3N5</accession>
    <name>A0ABR3C3N5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytosine-purine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100051</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616531.1">
        <property type="nucleotide sequence ID" value="XM_066754630.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91986909"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="57037" checksum="E6956A0079434A7A" modified="2025-10-08" version="1">MSITPPIHDEKDIEAQTYVSPVGRQHNHASTGGILEANDGVPRGKGFFAPLWKAMAWFDRFGVELASHILEYLQMIGVDAKCRWDNGTLWFSVNSCVGTFGVGYLGHLYYGMGLRDAALTIVFFNLLSCAPVAYMCTFGKELGLRQMVLSRFSLGYWTGTIPVIFNLIACCGWATMNTIAGVSCWRAVSTTHQIPAVAATVILALLALVISFCGYKVIHLYEKFAGYPVLIAFLVSMGTSAKYMDLPGAWGPSGPVEAAGVLTFGCAIVGFAIGWVGYAADFTVSMPKDTSSKKLFWVTYWGLAIPLIFIELMGALAVTTFSARPDWEEMFNDGAVGGLLAGLLQPCGGFGKFLLVILGLSTVAVNTPNVYIFTNTFHALSPYCQAIPRPFIALIVSIIYAALAAAGANSFSAVLENLLLFLAYWLAMYFGIVATEHLVFRKNSFDNYVPDDYTNWRMLPLGVAGFFALGLGWTGAALGMNTSWFIGPIAKRIGGGGDVGFELAFGFAVTTFIPLRYFEKKYWGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C440</accession>
    <name>A0ABR3C440_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616679.1">
        <property type="nucleotide sequence ID" value="XM_066754778.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987064"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF5">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="97"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="635" mass="69439" checksum="6D3F61284A1524D1" modified="2025-10-08" version="1">MASATNPGEVPQTSLSSQGQTNLRRQASRLSNTLTHMRSIEAYPPGDDKVIDLPPDRTEPSKDSEKQTLKGLNAIDIEHLPVDDDPREWSNRKKWTVLMIMTFAMLGPMMAPSIYNPVISDVREELRATEAELGLSISLYILFQGCTPVLWAAIAELNGRKPVYLVSYAIYVVALVVASRANSMPLLIVMRILQSTGSGPTVSLGAGSLADMYETHERGAKLGLFYGVPMIAPAVAPLIGGALGQSFGWRSVFYFLAVYAFIMLCCFVMFPDSWRRQRSRIYQRALSKGIERAEKEDAKDLKRKARLAKQPQVLDTIPAAPEGTPGTSPGGSTRPITEAGGRMMSESTMVNVILNNDQKQATGKLGKVKVKMMKWLPFGAKEKRIQAENEVEFKPTFRDLNPLPSMALILKQPTNLLILTSSALSFSAQYTIVYTASITLGKPPYNYGSLNIGLVVLAFGIGNILASLLGGKYSDIVLRKLKKKNGGVGNPEMRLRSTVLAMPILIASFLAYAWTAQEKVHIAALVVCLFFAGFSLLWIYSSTLAYVVDANPGASSSAVSCNSMFRGICACVMSQVATPIQNGIGDGGLYTLFAGILAFACACNLLLMVKGEQWRSPEHRWPWQKKREEGNGEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C447</accession>
    <name>A0ABR3C447_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit 5b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_100208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616681.1">
        <property type="nucleotide sequence ID" value="XM_066754780.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987066"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0255404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17077" checksum="50FD3D134FA33D12" modified="2025-10-08" version="1">MAFALRSLRTALPALRRTLPAPAFTARAFSISAARSAGHGPPQLLGPGAKAGEVPNDENQSTGLERFELLGNLEGVDVFDMKPLEVTRLGTVEDPIPVYSLFPERQIGCTGFPVDSHDTIWLSVNHTLKNHRCPECGSVYTLNFQGDEALLHGGGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C509</accession>
    <name>A0ABR3C509_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ran GTPase-activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616981.1">
        <property type="nucleotide sequence ID" value="XM_066755080.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987369"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="44929" checksum="2B0FD23B7B33ACC9" modified="2025-10-08" version="1">MSKVFSILGKNLKANTKAELEPYISQLEEMEDVEEVHFGGNSLGIEACEAIAIVLKKKTNLKVVDLADIFTGRLISEIPQALSALCNALSEHTSLVELDLSDNAFGGRCADALVPFLQSNTHFQIFKLNNNGLGPWGGSVIAKALLDNAAKCEKEGKESSLRVIVCGRNRLENGSAPDWAEAFGKHRNLKEVKMPQNGIRMEGIQALAEGLSNCRELEHLDLQDNTATKTGTRAIVKHLCSWPNLKHLNLSDCLLGSAGGIALATSLSLGSNPKLESLKLQYGEMDKRAVELLSVAISQHLKELTVLELNGNRFDEDDDCVEELKKALELWGHEEALDELDDMEEPESEEEESEEEEEQKEEEQEEEKETSEPDDGVDKGASGEDNLPPASEKQTDELADMLAGVHVGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C547</accession>
    <name>A0ABR3C547_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617022.1">
        <property type="nucleotide sequence ID" value="XM_066755121.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987410"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="78" mass="8569" checksum="80C5CD0FB33F8614" modified="2025-10-08" version="1">MMHRITAATNLPFAVFRPVFSPKINTAPNIYKPHSSPSASSSPLPPQLPTFPTAYITIRFCHLPLSYLFSSPIVPSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5A7</accession>
    <name>A0ABR3C5A7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleic acid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617080.1">
        <property type="nucleotide sequence ID" value="XM_066755179.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987470"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15614" checksum="9ED0261D2D7567D4" modified="2025-10-08" version="1">MFRPAVARPAASLARPLARSFVSRATFVGRLGTAPEKSTTSAGQPYYKYPLAVSKPPKRDADGKVILDEGGYPVRADPSWFTIFNFNERAEARIESLVPGSLLYVEANIDTITSPAATDGAPGTKQYVFREVSHKVLSKPRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5B4</accession>
    <name>A0ABR3C5B4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I308_100622</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IND107</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617090.1">
        <property type="nucleotide sequence ID" value="XM_066755189.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987480"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="282"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="177"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAL0255813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="346" mass="38123" checksum="61F4339B62DB988D" modified="2025-10-08" version="1">MALPPSLHVHPHFNAEEAAHVVTGFVSSLENLPGEVTFLLEEIREKDVRISQYVQRINSRHMSLTKTAKSLASLPPSTATFPLPIPPESLLPTSHLSQKEAQSLAKIQNEWTQVLTLQDEKVKLAERLERVVSRAKERARHQWVKVGGMEIEEVEKWSGTGELGNGEVVLPPYGLGSGIDGRPAKKRKPNIPSLSTNQTKQTINSSISMPPPPPPSRPSLSARSSHSNVPSASHTHTSSLAQHGPRSRRVSVASDEDADGEPDEGDTDMVDGADAEGETDETLYCICRQKSYGEMIGCDCDKCHYEWFHVKCVNISGPLPDTWYCPDCVARYGFSNDKGNKKSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5F0</accession>
    <name>A0ABR3C5F0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617129.1">
        <property type="nucleotide sequence ID" value="XM_066755228.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987519"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="1306"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="595"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1154"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1378"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1161"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1379"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1398"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1440"/>
            <end position="1449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1557" mass="170437" checksum="2F67F7450154EF74" modified="2025-10-08" version="1">MSPSASNPGYPPFLSPSTVDTHPSQYQPQPQFHQQYFDYTPQHTRYPPATYEYSPSGIASAPDQVPLVKFAGGGQQPFAANQHYSLHQQVAQQQPQLGTPVPSQYPYHLTHDQLPRLAASSHLSYGSPISASHYQQISQVSVSESPSLPSQSQEQSLAPGYQETTQVGSSASWPLPPPHTLPFSETSPRASVLPATIVPSQNGSNSANTSIKIRIRPPLSPVTIPEMVSSRPTRRSSQVHQEEHTVSASGRPQRGATRLAATKAIYKEDDDEELDDAYNSVDDDVDEEADGVIKVAPPVTTRSGRIQKQPQRFEDDFENAPMSASPDMQSGGRIAGGKAKRRVIVDPDEDEEEDAAPPPRNAFPSRSARNSLASANADSARHQPDTGTSYSNGKRSLRSGDRATARTRHSSADADEFEPTGGESTEEHASSDPLGNYDEEPEEEDFVVSDDDDSGYGKRRSSRRRTTRATARNTRSTALPTRRSTRSSAKARALDSDEDSSPHKRPNLRERTSRPNYHIPTLEELSKEISAQEAIAAVAGGSGRAPGGFRGAGGVRYGGVGLPFAMRAKDLTQAMGDPDTSDSDDMDFASPFKSGAAGPSISGGTAVAARGAAGPSDVPNFGRINPKSSTADADPLGVDMNVTFDNVGGLDNHINQLKEMVALPLLYPEVFQQFGITPPRGVLFHGPPGTGKTLLARALAASCSSGNTKISFFMRKGADVLSKWVGEAERQLRMLFEEARASQPSIIFFDEIDGLAPVRSSKQDQIHASLVSTLLALMDGMDGRGQVIVIGATNRPDAVDPALRRPGRFDREFYFSLPNREARKKIIGINTRSWDPKLSDEMLDKLASLTKGYGGADLRALCTEAALNAIQRRYPQIYRTVDRLQLETKSIHVKAKDFMLSIKKIVPSSARSTSSPAIQLPSHLLPLLSVPLKRINSAVDHVLPPKAQTTALEEAEYEDEAHEDFEKHIVLQSLDKLRTFRPRVLVHGQPGMGQIFLGPAVLHHLEGFHIQSLDLGTLLGDSTRSVEATIVQLFVEAKRHQPSVIFIPSLSQWASVVPELSRSTFAALLDGIPPSDPILLLAMADSPWAELPADVKAWFGFARENKIALDFPNTSERCAYFTDLLTSVRKPPTDFPDGVPRRKRVLEVLPLAAPLPPRQPTEAERARDEEKDQAARNMMVVSFTNLVKEFMKRYRKVVASVKDDAMELSRCLVEQAAASAAPTQSAIAVPNIIEDANNNAESQVNEVDGGMNVHPTTENPSESSPGDIANIPAAPVTAANDLTLHSASTSTSAALVPTTIWQAHNVDIDTIQRRLIRHKYYTPEDFLADIRKIEENAIKVGDPERQAKVVEMGANARLHISGFDPKWTPEFERYAERMRAKKAARQRKKEQAKETAEENGQNLAVSESTNPTAEILGMPDSADTTSKRPREEDDGADIEFQGREKRLRDGQPGATEEASVDVPGTLTSQSFPPNIACDPPQLDYPPFILPEQDLQSLQAELEIATADLTVDQLEQLRATLFDKLWADRKEWDRTVTVIKMRQRLQEYIKEVNSWKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5P0</accession>
    <name>A0ABR3C5P0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617209.1">
        <property type="nucleotide sequence ID" value="XM_066755308.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987601"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="15"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="390" mass="41513" checksum="AD20A6C60D4157B6" modified="2025-10-08" version="1">MTANQKSQKAVVCHGAVDLRVEDRDIPAPKPDEVQIKVAMTGLCGSDLHYYLHGANGTFKIREPLVLGHESCGIVTAVGSNVNAGFNLKVGDRVAMEVGVYCKTCKMCRQGRYNLCANMRFASSAKTYPHLDGTLREVMNWPAELVYKLPPGLELPLAALAEPLSVVLHAYRRAHLSPGARILVIGTGAVGLLTCALARASGCTSVVAVDIEQGKLDFAAQQGWTTSTFCLPRGPRVSGVEALEAAGKAWEALKASDAVQSVEGLEDGFDAVFECTGVESCMQMAPMAAAIGTKVLFVGMGTKVLALPCGPSLLSEVDLIGVFRYCNTYPDALALLASGKLGDVSKMASHYYSLDQAVEAFEDLKRGKDKDGRTVIKPMVGNLELCGIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5T2</accession>
    <name>A0ABR3C5T2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617254.1">
        <property type="nucleotide sequence ID" value="XM_066755353.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987646"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="228" mass="24643" checksum="205E7AC06D2858E7" modified="2025-10-08" version="1">MIMSEKPHLHLDFNSPACPAPAYSPPTYFSSPASPPAPFGNFSSQQYSSPFTLSRKSFSGIDSERGELPSPTMSGKSLGSPTRPSPRILMGAVVSVSPRRNSEELSLEVPGIVLTEPHPNPRPFPPPKQTVLLAPTSLPLPPPGSSLSSFQGHYQHSSISAKSLHQFSPAFTSFLNGTPTPYQQHQGRKSRMKALVMLGIVIVGGWHLWSTMMNEGWGGLVEEAVEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6H0</accession>
    <name>A0ABR3C6H0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617208.1">
        <property type="nucleotide sequence ID" value="XM_066755307.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987600"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="152" mass="17220" checksum="2A65F6487A39674C" modified="2025-10-08" version="1">MSEPPEYQKLLTKETESFDVDVEDQAATYPPGPSNSVSRVIFVYAPRFGFDDPKEYVGLVGKTKEETIQNVCRYIPELAEYPTDRISFRLGPSESSHPRYWAVATEDVWFTFESDPPAKLGVMVEPNQKDRDADRARKAKTAFIVITCCLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C726</accession>
    <name>A0ABR3C726_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100381</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616853.1">
        <property type="nucleotide sequence ID" value="XM_066754952.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987239"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="370"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0255576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="791" mass="88150" checksum="CB63715A0D6DBC64" modified="2025-10-08" version="1">MRGGRLLTQQSNMSVTSAHSQNSISPSGVLSAPGAHSAQPETEAAGGDLRVRFARACDRCRHRKIKVSLRAAGVTCTSGMSRPTGVGRQRASRTSFSDMRNNHEAPTEKERTPSSREQRPINKGRKRRRDSEETDKTGSHSNSKITNVLDHLDTAHFFLSQEGMPRFAGSTSGLPILEATRRLLQTKPDSFDNEQSPMGEPNWSWLSSLLEDGEGSSKNDRESLLRRQERDEPEYFPGRDHASEQGREDIFARISEIIPPDLMASLVQTYVGKQWSTSLTQSFFADFYKWTSYSFAALVVSMCMLATRYTNDPRVLAEPDILASAGFQYFELFRQLRAQASTEDNVIQAIQSLFLAAQYHCVDNVPHQIAQGLFAEAAARLLDGGLHREISDIALGDSLEKETRTRTAWACYSWDKQLAAICGKPPLLRIWDYDVSLPEVFEETELTSTQHSENQDEKLCAIFIQQILLSVVLEKTLTSCTHHPEFDNCEMLNRWARSMRLEVEDTKALDDSMRLLTEWREALPLTMSDRSIAGRLASPMYSVEYEQIAIIEQTIEMLIAGRKLQLATLAKARENTSTTRREFARDAILEAGKHTLASAVKMGSAKLLGRCDILLAYRILMAGRFLLASLLSARADCNAKQEEEATRAVRAAVVLLRHFADVYPISLGSAEVLEETCRVCRVNISLPTATSPGHPRHNLYAWHRPLRLRDKDSNQKNGYPSHVRSPTNVMTGDAAADAIASMFSPVDAGFALGSIALPFPETGTEGEKQPDFSWLLPGGSVPYYFPSHPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHX6</accession>
    <name>A0ABR3BHX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TEL2-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610766.1">
        <property type="nucleotide sequence ID" value="XM_066761226.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993661"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016441">
        <property type="entry name" value="Tti1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005250">
        <property type="entry name" value="UCP005250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="2">
        <location>
            <begin position="7"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="3">
        <location>
            <begin position="790"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1126" mass="123822" checksum="8E9EE1FF184AFA12" modified="2025-10-08" version="1">MDPAVINYVLFPITNIMRQSNPASLPDNFLEAAFNLLALMVGAWRKCDGGIDVVAWEQLWRFSAAAVGPRVVSREKDKGKGKEVGQEVQLNAVKLLAALLEPSTENTPILHPSPAMLEKVADSKSPLLPTLFQTITLLLETVLPSPPNLQLQISSLRLLRRLIQSYLPGKHQILAALLPGTVSAMTKLIDTEGKNLKGEAAQESAGVIETVITLTLNDHDLQELGVLRPPAEDLSQLAEEWEAANISTDQVPPPSPAPSNASIAPNPFPPLTASYLSFTATQLLSAIPPVLFTLVPHSSDLARTAASSLASSLVERCSESLPLLRPRALTCLLLLSQDTFDPVRYDARRKLRQLLSTETSTLSLTLVDLLSDAVNSLPRLVTSQQDTRVDEIARLVTAIAEASTELSRSRKHPLRGNAIAALLGPNGNVERWSWALLDCLEFGKPSGWSAAAGTAERAARLGWEGGFSQNSNLLLVNGAVQEQAADEVEAIGSFPHLPLRYIESDATARRMGEMLSALGSAANEAALYSVEYFVKFAKTNRRRHTVKAVSSLWVADRLLSGVMVSQLEGVEGKVSKVTRKMAKEVVKAVIAMEEDGEEEEEDFAYDQEDTSALIPIERTKGIDTLTTLLDRNPLPNSHTATETRRLHLQAQQMLLTSLSLQSLSLSAHILSSSFRPLLLTTLYIILSHLASPHPIVQSYASLTLSHVAQYTGYASPAALVLDNVDYVINVVTQRLTYKRLSATAPLVLIAMIRLVGEPIVPLVHDVVDEIFDALDDYHGYETMTSSLLAVLVILIDVMSKKVKLEVEGSSDEERKRKAEKFSRIGKAPDPASDFAEFGKWWEEKAQRSQETVSEVLERAPQHAWGEEEAVNEDQDETPGEDDAKMEEVEIPATRSQQVATRILTKALFFLTHRSPFLRSKVLSLIADSVPILALGNRESDLLPLIHDSWSIILNRLDDPEPYVVVEAAEVIASLCEHVGDFMSKRVLEHAWPRLLKLLNDQRELDRRSALARRGGMGTESSFTVSHRLHIAILNVAIFIAREVPVADNVLWEMMLSFRAFVDDRVHEDLCGKAMQLYTELGKRDGDALWIVLNGTLGNGVIGDAWEYLSRVKLSIERCASILLEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BII0</accession>
    <name>A0ABR3BII0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I308_106292</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IND107</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610997.1">
        <property type="nucleotide sequence ID" value="XM_066760725.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993147"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="178"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="312"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAL0240498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="352" mass="37404" checksum="7F511CF129CC0476" modified="2025-10-08" version="1">MRRTNGGAKKIPLRGIKTLTFYADKYTAGRRTAPIPQLTCQGPGCKIFQPDVVQCTNMGDDGLGNVQWKCDTDLPTSLRLGKVDVSCEGWSAKGDPDILQGSCGLTYNLYKVNKGLEYGEDPYSTLPSHYNRLFVDKAFNVVFCVVTLIIVYSLLRSLLGRYAGWRLPGLWPHGGGGGGGGGGGPGGWGGGGGGPGGGGPGFGGGQAPPPPPPPYTKHAQTPTQPIFTQPPQAQAGQGTWWNPGFWTGLAAGGLGAWLVNNRTNNNNNNNNDNNNYRARQREDGYRGFLPRRGLFAGREDDWGRGMRFRRVVDDDGDDDNEPWGRGARPGGGGGGGVGEMRRATGFGGTSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIV6</accession>
    <name>A0ABR3BIV6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610891.1">
        <property type="nucleotide sequence ID" value="XM_066761066.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993498"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="80" mass="8936" checksum="D1EDCBA5BCC34A1E" modified="2025-10-08" version="1">MHCIASDYEVVTLATVTPNLASMSLTHTCTNRNPLASTDCPIHVPPTVHQDHPGESHRSRTGIWFPSPSGGWYRPNRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIW9</accession>
    <name>A0ABR3BIW9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Barwin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611135.1">
        <property type="nucleotide sequence ID" value="XM_066760863.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993289"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001153">
        <property type="entry name" value="Barwin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF25">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00967">
        <property type="entry name" value="Barwin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046071773" description="Barwin domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Barwin" evidence="3">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="131" mass="13756" checksum="C844F00AB21AD399" modified="2025-10-08" version="1">MFTKIFVALFAATAVLAAPIESAEKRATYSGQATYYSPSVGTGACGWQNTDQELVVALNAPQWDATANHGCGQMVTITNGQNGQQQQAKIVDMCPGCAEGSLDMSPTLFGALNNNNLDAGVFPISWDFASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ18</accession>
    <name>A0ABR3BJ18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rrn9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611181.1">
        <property type="nucleotide sequence ID" value="XM_066760909.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993336"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59060" checksum="FDF3EE0536DA090C" modified="2025-10-08" version="1">MSTHSHVDLVRALESIDQNVLHNDTLSSHEHTHHGHHDHITTIGHDHEASGRQEDLSEWTREELQAEIVKLRQMAGIANDSSMTAEMLPTSAEGSTDPSLRENSLATLSAEGNNSKGKRKRKSPSNDVTTRKIQKRHSETGKRLEKKRRTELAKMRSSVGMEFNSSPVPQPMANLSDEERGFTPFVPEWRNMLDKDNLAWVDKISKSVQEEAINGLHPQIPEADLIPEIVHGIACTAFTNLCKRFINENSSDGMDRRERYIKKRRRWARKDLKQKRRSRSAASPSISLSLPTSLPASALHIDYMSSEYSSSGDDEPEVHPHIRQMQKDKWREMVEEAQRDVRVAAGTGRSGWKAGHGPKVLEVRKPKWRSQQLNEIYARLDAHADAYADTRATGTRPASSSQSTSAIPRAGHVAPSHNRFCLPPELGRRGKAPRDLGEGWMWVTGVVGVWPEDTEGAGDDVGRVVEVGVDDAEREQVENEKGAGGEEMEVGTGVVDEMAEVTLAQMGQWGTSEEVMDEADRLGLVSALDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ36</accession>
    <name>A0ABR3BJ36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611194.1">
        <property type="nucleotide sequence ID" value="XM_066760922.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993350"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="989" mass="108085" checksum="8D3A3EEEBC43B061" modified="2025-10-08" version="1">MADNPVLQALQTLYHDPDTAAKRRANEWLQEFQHSTEAWQTAHVLLNAHDSPLEGRLFSAQTLRAKITYDLSQLPRESLPPLRDSLLNVLLPLSSPSAPTGSKAVLLQLCLAISDLALQMPEWENVVPSMIERFGTDPAMVTVLLLFLKTLPEEATNPRIPLGQDEARAILNRLVSGSAGRVLEVLTMYIQAEGVTTPIQISVFEALRSWLQAGEVTASQVAATPLFSAAFSALASDQLFDAAVDLLCDLIHETQELNDNMTVVQEIVPRVIALRGEMERYKEDPDRVRGYCRILCEAGECYQSLIVQHPGDLLPLVQAIAECAAYPDLDIVPITFYFWYALSESLERQENFSQNPAYTPILSIFSDLQSIIISHLHFPPDDEQQTAQERDEFRTFRHRMGDTLKDCCHVLGATVCLKKSYDLILSALSQLSPSWQAIEAPLFSMRSMGAEVDPNDDEVLPHIMTLLPTLPQHPKIRYASILVISRYSPWLNRHPEHLTFTLSYVSAGFEMADEQVSAAAAHAMKFICQDCTTHLVPFLPQLHMFMEGAGERLGQEDVVEVCEAIAYIIDGMLPAEAASALSQFCSPLITRIQTLLSLPPSVPSSSVSVSEGDLEKISDMLEQIDAYLSIVRTLSPFPPSCYSSAGRVYAILDVLLEKFGGVYHISEKVGSVLRRGLIFFPAEVLVGSGVGPEGEDGDRSGGTRGGEGGLVSQLIKRMQTSFEETGYASYLWIMGKIVDRFSDMVLSSTSGGETEAAGRMVGELLGRGFESVTTSLGRLLERKVAVEIPDVMDDYVHLFLSYLIHLPPILASPLLPLALSHTLQALTCPATSIILTSVDVLALLSSHLSLSPSPSAASTSSSRASTPKNPSAVRPIFAQYARPTLSLLLKGLIADFPDEASEPIGQVLVHFAVAFGGGGEMEAWVGEALAGVGGHLVLPADKEAFLGHVHECIANGQPEKIKYAVHGLLRAARRMRERGRQSRKSLGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJD0</accession>
    <name>A0ABR3BJD0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF895 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611284.1">
        <property type="nucleotide sequence ID" value="XM_066760523.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992931"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF17">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0241902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="52643" checksum="08E0B88609672E07" modified="2025-10-08" version="1">MAILRYLSQLRVGAARYNSPWTQVVIVGFVCFCSVGMFSAVSGLGAGGTQDTALSDTANGVLYGVFAIMGIFAGSINNILGPRLTLSIGASGYSLYVGALWAYQVHGTRWFLILAGGLLGVTAALLWSAQGSIMMSYSMEKDKGRAFSLFWSIFQMGTLIGAAIALGIQAHSTLPSVSTGVYLAFMIIQLTAIGTSWLILPPHLVVRGDGTIVKLDDAITPKEEARHFLKMFKDWRMLLLFPMFFASNYFYAYQGAITAFLFNGRTRALVSLLTGLGAIIGAILIGVVLDRVPLSRKKRSMIGCLTVIVLNIIIWVGGLVFQLKFTRHTEHTVWDWSDGAATGPIILLMSYYIGDAAFQGLAYYTMSCISNDPFKLARMAGYYKGVQSAGAAVSFGMDAVATPFLTEHLVSWIMLLISLPLCGYVLWSTNETNYETEGVVKVEDVDSSAVGGAALPKGHHMHEEEKVSVDEKVDGHVANVMRVHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJI9</accession>
    <name>A0ABR3BJI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_106136</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611344.1">
        <property type="nucleotide sequence ID" value="XM_066760583.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992991"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="68"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="216"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="827"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="13">
        <location>
            <begin position="981"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0241962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1114" mass="125521" checksum="BA7008E307DBF54E" modified="2025-10-08" version="1">MAANVNHNAPAGAVVVMEKTDKRDYLIDLEKTAQASWAEQQLFETNPPPLPEGINSYSEFFASGKSMEEIHEKNPKWFGTFPYAYMNGSLHLGHAFTISKVEFAAGFERMRGKRVLFPVGYHATGMPIKAASDKLIREMEMFGEDFSRYKEDEPEEVEPAAATAAPAKSLESTDPSKAKKGKLNAKSTGLTYQFQILELIGVPRDELKKFADPYHWLHYFPPIAKEDLSGLGARVDWRRQFVTTDANLYFDSFVRWQMNKLYKQNRVKFGKRYTIYSPKDGQPCMDHDRASGEAVNPQEYTAVKMEVLEWGPTVPEGVKKAIGGKKVWMVAATLRPETMYGQTNCFVGPNLKYGLFEASDNELFLVTERSARNMAFQGIFDRPKGACNKVADIMGSDLLGTKVNPPFGLVKEVYVLPMEGVLATKGTGVVTSVPSDSPDDYRTLMDLRKKAEMYKIKPEWAAVDPIPVLKTPKYGDMAAEVLCTELKIQSQRDKDKLAEAKDLAYKEGFYNGVMTVGDFVGTPVVDAKPKVREQMIQAGLACPYAEPESEVISRSADVCVVALVDQWYLDYGEDGWKTQAFKLLDKLNTYQDETRHAFVGVLNWLNQWACARSYGLGSKLPWDPVWLIESLSDSTVYMSYYTVANLLHQDMFGKNPGPLGITPEQMTDEVWEYVLADGQLPPNSPVDAEKAAQLKYHFNYFYPLDVRSSGKDLIPNHLTFWIYCHTALFPEKQWPKAVRINGHLMLNGKKMSKSTGNFLTMKEATNKYGSDATRLTLADAGDDITDANFEETVANAAILRLHTCSTWAEEMKSTKDQLRTGEWNDFDRGFRAEMDALIKEAYGAFEQMEYKRALKAGLYDFENARNWYRMVSDPVNSGSGMHRDLVFAWLRAHALLITPFTPHYSEHIWKNVLGETSTIQTALFPEPSGPIDPAVLEQTEYLRGVVDAIRSAEAQAGKKKGKKAAAAVYDPSKPKKVRMYVAKNFPEWQEKAIGVIKNHAWDGEKVDDVKLRKGLEEVGLMKDKKVMPFCQAFKRKLAVSGPSAFDRTLTFDELYSLKMLAPLIKSSLRFEEIDVLSVEEAREIIEKDGEKEGWTKEKVEVAEPAVPGVQFWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJJ3</accession>
    <name>A0ABR3BJJ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_106134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611342.1">
        <property type="nucleotide sequence ID" value="XM_066760581.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992989"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0241960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="459" mass="50277" checksum="9AD897422DEE7A22" modified="2025-10-08" version="1">MGKEKLHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKSSFKYAWVLDKLKAERERGITIDIALWKFETPKYQVTVIDAPGHRDFIKNMITGTSQADCAILIIATGIGEFEAGISKDGQTREHALLAFTLGVRQLIVACNKMDTCKWSEDRFNEIVKETNGFIKKVGYNPKAVPFVPISGWHGDNMLEETKNMPWYKGWTKETKSGVSKGKTLLEAIDAIEPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKAGMVVKFAPTNVTTEVKSVEMHHEQIPEGLPGDNVGFNVKNVSIKDIRRGNVCGDSKNDPPMEAASFNAQVIVLNHPGQIGAGYTPVLDCHTAHIACKFAELVEKIDRRTGKVMEAAPKFVKSGDAAIVKLVPQKPLCVETYADYPPLGRFAVRDMRQTVAVGVIKSVDKTEKGGKVTKAAEKATKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJQ1</accession>
    <name>A0ABR3BJQ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0242022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611404.1">
        <property type="nucleotide sequence ID" value="XM_066760643.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993051"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="321" mass="34784" checksum="777350E93E7237AC" modified="2025-10-08" version="1">MGRSKPRTNKRPPPKVRPNPPTQPSPPPTPTQNPSTSDQYATPPSILPPSFPPLPSDILSVPRSTLASADAAAARATATAANLSAALSSWSANTLGRMEPLPKLTESQLSVLAGAAAGIGEANFLSGMSAPRNGQSSGSTGEGQYGGGIPIDLPASLAALFEAKLTLDREKAKLMRMQKELRGQRESIKEVEMHMETEGMASQMSAETMASPPTPMLEEGCTCGQCLAYASESELECYDCEDDCGCDCHSYEEYDCSHGHHEYEEDEEYHERKRPLSEDPARLDETVRELFNWIKAVVWTIEQAAIVSGRRNWKQSSTKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK10</accession>
    <name>A0ABR3BK10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar import and degradation protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611507.1">
        <property type="nucleotide sequence ID" value="XM_066760203.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992609"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="54248" checksum="4C0E934C9BBF3D06" modified="2025-10-08" version="1">MPTESTPSELPLPTPHTPGGVVKCSICGIGNLSQPVSVPVSDYFGGSAIELGERVCGRCAVARGHGESDIQSQSHNENRSRDRERGCEKESEMRERGRGGMKQESERTLDDVHEENETAERKDIVHDLKIPTLSQSLPSQLTRPWTTSKPTSSSSSNARRLTPPPKSEATNRRKEKIDQPPNPLLDITRMRVRSLGRGPLYPGSVFKGTQTSGRSAYDVEVKFLDVDFADSTLSGYLSISHLTDSHPHLTTFFTGEIIGPKYGFITGQRYAATEHDDLRHWGRFEQFRRPSTRADLVGEELFLRDPLPDRSRGETKGKDRDFVFLRIKEQFLVPDHKVKDISGASFAGFYYIMVDMAPTITVPVSQPTTPLSPGFKSPFVPGSPASGRRTSGTGMPALGLGMGMGLGASIGAGMGAGMGVGGAVGMGGEQVSGIDRARPARPPRRESSGRMKEREVRGEATIRGYYFHSLNQEPFQELFLTHVPQKSKRAFEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKG8</accession>
    <name>A0ABR3BKG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_105921</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611674.1">
        <property type="nucleotide sequence ID" value="XM_066760370.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992776"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0242292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="53990" checksum="13BC9637DD99F09F" modified="2025-10-08" version="1">MFPYSLINATGSIVISAVTLISALYLFLVLYRQGKGKLRVRLLVGMVISDLLLGLVILPPVAMYIANRKLATGSAGCNAQAFILIATLFTQHLWTLVMAVSTFLLLRHPLSRATSLLERYSWVIAPVIWGLSVLHAGLWYHYVGFVNAGSLCYYGTRSAKDGLDREICQFVPRAFVFVVVIVLYSRLFTFLRRPDTIQLPSHHASKTSSFTDTRSGQTGPRPIAKFHKLSLTSSQGAKRDPEAPWEAMEFIQVGNVDFLAPDTTTTFIDDCAAMPATTAVPATPPSSSLFRALESSCSSTKTLSPITSPSKTDDPSSTVQPPYDGGAPISSSPKIRSLGVEASQTPTTVASASCKMDPLLGPEEREERVGEGARELKEQGQTMQEFFAEYQMTPAEAKAVGKHVSQQRSAANYFNRQASLLMLYFPIAYMAVFSVSLIRLIYDMSHDTTSPVLYIMSNWTVLSVGIIDGLVYGIAEFMVRRKVRKKMPEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKQ0</accession>
    <name>A0ABR3BKQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611747.1">
        <property type="nucleotide sequence ID" value="XM_066760443.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992849"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="779" mass="86634" checksum="D07948369403E2E0" modified="2025-10-08" version="1">MLSSPRHFLNTFHTPSQRSTNASQTSFTSYAASHTTHDTHRANSISNPNLKPHSQSLSPYVPAPTSMAMAADRDFAPSIYRSTQLGSERGGGGSVLQGSVTSHMSKSSLFRNPFKKNNDLVSQLERAERAEKDRERQKETVKLKEYEKEKENEREMREPLGRSGVMKQGTAMIRRRLSITRSDVRAVVTPTPKARENGIYGYGDEHEEVMITVGSHDEMHDFHSPTQRPFSPIVTRGFLKTPTEVITSLSASLNKNKASSRPSPSSISPPMLTQRKPEDPINLNIFDSSTSFPNYDTDLDVDAIDTFVADATLKETVKSITRQVKMRPKSIYVKRLSKRFGKANDTEVSPKHSNCEIPPALQLPLRAKPLSAEYSLRTASVSVHEASRHIPTKEELMNMALPPHTPQGLPSRYRPNGTTIFDIYPDEDLDYHPIPPPRTPRITHLGPNVILNSTTSLRPHDFMTDINTNTNLSSSPNTDTDTRQRTMGPRSSRVFDIPNGLYDLWQYGMDEPEIMDISLNEEESARKRILPMFVRIRSTGRRLIENARLQSPDPDAQNQGLKMGKDGLARSSNRMLNDLTDGPIAMGSNPFRMEISPASLDSGSESSCNSQLSEVSDESQMSEGTRALGELVGLQGSSESGIGLLVYGKVETASKMSLKYATPRAAGRALAGDMRADDMADNASAMTSSVSQASQISGIWDYAALIDDHDHASSQVKANREKEKKDIPVAVRTGKWHLQMQSRYQVWSSAVILCLSMRFEEIEEWYVFLVGLISSTKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKR6</accession>
    <name>A0ABR3BKR6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferritin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611752.1">
        <property type="nucleotide sequence ID" value="XM_066760448.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992854"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF26">
        <property type="entry name" value="OS05G0151100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045359988" description="Ferritin-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="32517" checksum="2154C6DD29335E8D" modified="2025-10-08" version="1">MKLFTAATVLGSIALAVAAPVREAQHIKRAGEPTDLQVLQYALTLENLEAAFYSQALQNFSADDFKNGGYPDWVRGRISQIAQHEASHAKLLSAALGNNSVAACQYKFPYTDIASFISLAAGIENIGVSAYAGANQYITDPTYRSVAATILPVEARHQGFFQGPVMMSNDWTGPYDTPLGLDMVYTLAAQLITSCPSSNAMLPVNASKPLLNGGSPIFAAAGGATISLTYDGAGANQSLAVYNGLGSTMVAIHNGNVTLPQGLQGYSYLIVTTAADIASVNTNNTVAGPAEVQSGFDAFQSNPGFMNPYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BL29</accession>
    <name>A0ABR3BL29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_105448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611849.1">
        <property type="nucleotide sequence ID" value="XM_066759903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992303"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047287222" description="Bromodomain associated domain-containing protein" evidence="6">
        <location>
            <begin position="31"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Bromodomain associated" evidence="7">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0243482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="481" mass="51619" checksum="E0BAB057069CA494" modified="2025-10-08" version="1">MAHPPAPDAVLHLTALHALAAAGFASTSRAASITLSTAMAHYLRLVAATCVERANLAGRSKVSALDVAEALEALGVRVGELCEWAEEQGEVVFDKGPLSGLDGYLQEGLLVEEGMAQLRLVPESDLEHDEELEDDEDDVMDDARSVKSEQEPIDVKPDLLNMRLQSPDLSWLPLLPNGDDVTSQPTRQLSASLPSVPELSAAPQSIAERYRRAIPYASSQLSQAHPLSPPHQSPPPSVPNSTTSLPSLISTYSAVASDPSISLRQNDLRRQAAELLRRTITPVDAFSPKDTLSTSIPPIRASPIVPSHSDILPPKLVPINPRPDGILSSLVQQLSSPYLPPPLRDRLISLRPPVAQMRHGEPVLYGPAVRGPDDALLAKAKGKHGEEVLPEAFLRRTWNSGPRGAEKYGRRTLPTGRKVICSAEGEPVPRVGQRSLPEALPVQSGDTSQEAKKVLLKLSSRGPTPTPVSDGNSLSPRTQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLA4</accession>
    <name>A0ABR3BLA4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611945.1">
        <property type="nucleotide sequence ID" value="XM_066759999.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992400"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="199" mass="22126" checksum="C2ECB47859AB9444" modified="2025-10-08" version="1">MPAYHSAFNQDTSVRQVGNTAILPITTKIRGPAPLSSDPSQPDIIEESLDLFRANCLFRNFEIKGPADRLLIYLILFISDCLTKLAPTAGKPSPSYQEATKVLQTLSVDNFALPGDAGFPLNSLYHPPASRVDADHLRSYLTQTRCELALRLCDRLYPHEQVIGPDGQPTGQLGPRATKPSKWWMSFQKRRFMGRSLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLD4</accession>
    <name>A0ABR3BLD4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611806.1">
        <property type="nucleotide sequence ID" value="XM_066759860.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992260"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="1">
        <location>
            <begin position="323"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="641" mass="74069" checksum="8C3A852F29229B0D" modified="2025-10-08" version="1">MPPRFKVSRLTFTVALVVLLTYSYFYLSSHSEDNLGLKIGNVRGSRHPLSPLDKSHSPYRGLMHWWSPSASDEPLGALKFTGDGLVRGWDGVYNMLKSGGLKRSEKKKLQLAMETHPILELMGRNHERWESLLASQSKTLPQAVTEYTRRYGRQPPKGFDQWWQFCKRNKVKIVDDYDQINRDIELYFALSPELFRKRVDLLKETPHTSQITLSPTGSSSLYGERAHSARARLLFQLIEPIAQFLPGDITLSLSDHDLGSWLLGDDQKQAALDAIRDGRYLTEEELKAYEKREGRLPVKGLVSACPPGSPGWQRGVAKRDGLEIEELSKETTFIYDPDLTYDYCYNPELLDIHGALSWDFTRETVLRPIFQLSKFARNPEFLTTPLEAYENFTSSAAQKKYAPWNEKTIDKLFWRGSSTGDSYSKRPNGLTWRQSHRPRLALKTQATEGEEDVWVQRGKTWEKETWSVARLNEAYMDIGLTGGPHQCKKEDGTCDEMKQEIIFKDRVAPEDSAKYKYVFDIDGNGWSSRFHRLIMSGSVVLKATIYPEWVSEWLTPWVHYIPCKIDYSDLYDIMSFFAGPPDGRASGHDDLAKMIADQARQFGEDHWRWEDMQAYMFRLLLEYSRLLADDRDEWSYQKTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLJ4</accession>
    <name>A0ABR3BLJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_105636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612035.1">
        <property type="nucleotide sequence ID" value="XM_066760089.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992491"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0243668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22885" checksum="C5878EFC8F7CB3B5" modified="2025-10-08" version="1">MAPKPLNRKLVVLGDGACGKTSLLTVFTKGYFPTTYEPTVFENYVEMMQVDDQVVELSLWDTAGQEDFDRLRSLSYADTHVVMICFSVDSPVSLENTESKWIHEVNQFCPGVKVILIALKCDLREDPALKEKLGRHSLHPVTYDEGLATARAIRASRYLECSAKHNRGVQEAIYEAARVAVGSRARGGGSGGRMKGDSWKEKCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BLP0</accession>
    <name>A0ABR3BLP0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612082.1">
        <property type="nucleotide sequence ID" value="XM_066760136.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992541"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="701"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="864"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="867"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="897"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="934"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="943" mass="104810" checksum="A78204B6891F0AE5" modified="2025-10-08" version="1">MSEPTEQTSPKPGFTRGGFAPIPHRHSDIAPLPSTTSPAPALPLSPSRAEWERGRGKERELPRRELDPEPEDRERRREWDDYPPRRESRGHWEDDFDRPKRRRSPSPLGPSHRPRLNSPSPPPPRFNIPDPASIETLLPFRTFAEWFRTSHPQTARVDEEETRKHKEMIESGQATEQEAKEKVGMAKRYERYRKEFTSRQLYALFLTHRDSAWFKEKYLHFPEYIALRRRLNRQGRIPQVTQYISELRSGAHDQVSYDQIEDVPGVKLDEDEPEGLNRALGDKGEWGEDSVVRVELAPRTKQVFVKTVPPNCSRKALEDLFSKVPGFQWLAISDPSQKRSFHRVAWAQYGEDTDVSQIEGFTFHLTINTSPTIGRVRVAPPSVNTLDRLLLDGTRAKSLALKLEGELLGDDEESVKGEGEKAKPEGDSKVEGEAAEEKPEVPKSLGLREKGSDMVEEVIMKVIEERGLTGEDLDEEQKVQKAKITLDQWIAYLRHGLSTCFYCVAPCAFMEELHRKCIAHVRAHPSSSTNEHVHEHEHEHEHEHDTEEHARAEVEDVVKSEAVHGADEVKAELEVEKEEEKVANGEEVEKEVNDEDREMRDDGQGNSKTLPAAHPSNATTNDRSDRERERKSRKNTFPQKTAEEKWIESHDLRIAPLLVSDLNLPEEEGGLRLGDYGGRDPDEELKKLCAPLIKQEEQSKYRCKECNKLFRAPEFVIKHITTKHTDVTQGRIDDVLYLNNFVLDPQHIQPSVSTLAAIDDKLPASSSNPLNPSLPSSLPLNPFDPSVAGGAFNNSQINGMPMSMGMGINAGGGHGTPSGQGHGQFNLMQQQMMMMLQMQQAMMMGQMGMGMGAGMGGVNASPMAGGAASGGAGGGAMSTPTRGGGIGGGQLAGRMGGYAPSPANLAPLPPPPPGGEDPRARRGRVSYQDLDEPGAGGGGGLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM07</accession>
    <name>A0ABR3BM07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_105058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612164.1">
        <property type="nucleotide sequence ID" value="XM_066759517.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991914"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="130"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0243797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="552" mass="61885" checksum="51FFEDC4A46E5FDA" modified="2025-10-08" version="1">MEHTTDIRVGPSKLTASQSPRKAPEKSASSTPVINDDSDDPRPTPAKATSGLATGGQGDEEEEGEERMDFKLIQSFADKVQHLPTADSVDGLTSRPQIIIPRRGEKDFEPLQETVNLQEMMLEKSRQALFNALIGVRGGHNNSISHALLTPNKPFSRLLVIHGHLLDTMGITVRTPPPADSKGKGKTSLELLPEEALYLLERGSLQIWIGKDPETDEEIEAGVGEWCDDEYGVKGAIEMSVMEGFGAFIGREGLTWERYQAYSYLKRLGYNVQRSRQFIPEYFLAAPPVQLDAQDPRLPPFRTWWLNIPKWIVKFFKALVRGVQRLAGSMASVGLGLRLTRDPFKGTMLNGWRGSTYYSLFSHLRVIPAGHDQPLPPRPSLSPSDDIYAPLLHNPYIPFWHIWKPMTPWSKRNWDKGSEEGLKTQRPDYFAAVIQARTTPLPSIHQLEEIYAMLPDEPKGPIKRYGPQYQRPPRPQASKPQTQTPTRIPSRLQSLLECMGWKQQAKSKPQVPSVNVGALRNGDRGFIVGVNDSGNNAWIRFGRTDFSQTPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM10</accession>
    <name>A0ABR3BM10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_106278</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <topology evidence="10">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610983.1">
        <property type="nucleotide sequence ID" value="XM_066760711.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993133"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044964700" description="1,3-beta-glucanosyltransferase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="13">
        <location>
            <begin position="368"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0240484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="546" mass="56661" checksum="5FAB2EAF83AD6890" modified="2025-10-08" version="1">MRLPSLALAGIQLLTMVAALPNITRTGKYLYDESGHRFYIKGVAYQPEGQLAASSDSNSANGGFPEPSSFYDPLSSPQNCTRDLPYLQQLGVNAIRVYSVNSSLNHDDCMKMFNDAGIYVLLDVSLPLNGSIDRSSPSWSTNLLNSYIETIDAFKDYGNILGFNIGNEVVNLVSNTNAAPFVKAAARDIKAYLKSVGSSALVGYAAVDGQADFRNSLAEYLTCGGDSIAVDLYGLNNYEWCGNENINSSNWNVITEGFSNLPVATYMSEFGCITSPPRLWTEVTALYASPVSDVFSGGVAFSYFPTSDGYGMVTISSNNTSPPNSPAKSSVTANTTDCPAESSSLLASSTLPPTPDEKFCNCINENSLSCIVKQSSANSPEIVGALLDYTCSLLGSTDSSASCDPIAGNGTSGTYGQLSFCSPAIKLSYVMSTYYQFNPKDTSCDFSGNATLSPNRPNTVQDANAAASSCLAAEPSGGVFTPTAPGTGAATSTSSGAASGSTSSAASSDSSASTSGDLRSITVVGGMLTAVVGIAGILVGGSATLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BM19</accession>
    <name>A0ABR3BM19_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanyl nucleotide exchange factor Sql2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_106102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000012">
        <property type="protein sequence ID" value="KAL0241928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611310.1">
        <property type="nucleotide sequence ID" value="XM_066760549.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992957"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056685">
        <property type="entry name" value="DUF7783"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="907"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="1109"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="641"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="802"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="768"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1052"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0241928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1363" mass="149656" checksum="4A30BC88E82F32A4" modified="2025-10-08" version="1">MPHRSDDGPAAIHDFDPSLIASTSSSSSNLYLSFKAGEIIRVHVRDPTGWWDGEITSRVAADNDGRTLRRGWFPSNYIREIDWDPTQRRADSSMSVTSPRSPYKRTHSRHGSVASHQSNASSSSISQIITSPRADIAPLPVAFQILIQPIVQSLSLLDTAIHNNRKSHIQPSTACVISSIRAALSQTDCLSKESQTLVSWPVLAKERKVVLVELSRLVGCARTASGMTDSAGTTSPGGEMEDLEELAKSARGVFQSVKRFLNLAHQCGVQVTLDTQNEGVPMSVSSSASSEIASVSALVNASAKTRASPGSNARLQEAFQKRVASIGDLRAAKQRSESPPPPPTGSSQSSKHAHTRTASKISTPISASFSDVSFPLSSRPFEHRIQGSMDSVFSQGSPATSEKLHAPWEDRTSVPTATAQPSTPCSNSITDIRMRISYAEDTLLSIIAAFIGHIHSHHIHSHPSSHSTLIEMTRETIDAVRTLLTAVETVGRNASIRSKRPKEIESLRIAKDRLYSVAGRLVESAEIVANAPFEEVVEEGYEKEKAELLGAATGTLRAGTECVRLVRICVPEDETINLNATPKQTASAASEQLTPRIDFDDPVVERGGTVGVRGPHTLSSLHRKATSLDHLQKRFMEDGGMVLGQFYGGPQNDSRQEEEEEEEEEEVIDEKEEDRTKRPSQGVMFPPSPDPSSQEVQLYPTPRPSRPPHELLRGFSETGGRGPRVRSTSLSTSPTPRVGHMGHRSPSRSADLDKFTSGEGLKLGTDVRPGEAGETRDKLEASESVTVTSDRLSVYTSISSLPSLANTDSSAKPASENDDQSTPVRSRKLPHGSLRVVIPKGISNQMSALSLQNSAEEPVSTARTSTTLKTLPSRPATFLRTQTSPMPVISYLIQSPTYSPADITYNPDGNMVGASLAVLVEKMTPHDGHVDPNFSSTFFYTFRLFATPADLLEAVQQRWYISPPEELTLSERDEAIWRDAKVMPIRIRIFNFLRTWLEFHWQPEVDNIILDDLGKFGKEEVGGSLPVMGERLVNLVQKKKEGREDEKRTRESISGPTSVSSGTLHPPAVSSLPPTPIISKNLHSLLKKSTASFSSSSSSSVRIHITEFDTLELARQLTIIVSKMFRQLKPEDLLMTGKKTVPELKVLSTHSNQVTGWVADSILNEGDAKRRAALLKFFIKLADKCLLINNFFTMFAVLGGLNSSTILRLKKTWDALSVKYKVLIESLRGIIEHTKNHAAYRARLKQAPTPCLPFLGLILTDITFTSDGNPSTRPSNSAPDLMLINYDKFSKLGKIAIEFRRYQEPFNFHELEAVQTFLHTVLTERGSGSIDALYRKSLMLEPRQGSEKLRSNVEKPSWLIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMB8</accession>
    <name>A0ABR3BMB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial distribution and morphology protein 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612269.1">
        <property type="nucleotide sequence ID" value="XM_066759622.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992021"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0243902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="75393" checksum="269080B923E4892A" modified="2025-10-08" version="1">MRPLLLPLRRLPTSATIGPRRTASADRYLAIHYFFTHHAVQPTISPISRHIPRRLNSSSSKRCLDCPTDQPAPNPDNPTPPPPQGHAQDYAPFIQRLIRQSKAIAPNSPHRPSKEELLEAANGWWQRMRIRLKWFTIRGWRRFNTDDMSAFASWFLVGNTVWILVGTTTFVSAIFALANSLSLQEYLARWLSDYMTYNTGVTVIFESAIVPKWGSSLITFKNVYVSCRPGEGPSYSPVEGSKKQVKAATAKPPTPVPFLSSAISPETYLAAPPAPPEDNYTMYDVNIDQLEVSLSFMRWLDGKGLVKDVRIKGLRGVVDRRSVWWDLSKPLDPADFRHATQKGDFEFESFHVEDALVTVYQPGLRPYNVSIFNMIVGPFRKRWLFYDLMSAEGITGQFDNCLFSLHMPQKLGKSVEKEGGTVKRMARFRIDGLPIEHVQYASGYTPPMSWLTSGKLDAVLDIKFPHHPDDQVDLQALFAEIGRNVATISHGVHPDDPEGDKLKGAIESAENSLVGVIPGQHRLARPPLRAPKKGDYGKEEEERKVVVDIDLRFRDLKAAVPLYTTDLTVTNNALIRPIVAFINANKTLVPIHCQVDADLSNFEGSWTLFETGLMTSISDQIYEAMAFHVSSEAANSRRLRQVSVWGIQRSAEMLIDMLRGVVDPVGAQFATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMC2</accession>
    <name>A0ABR3BMC2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone deacetylation protein Rxt3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611965.1">
        <property type="nucleotide sequence ID" value="XM_066760019.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992420"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0243598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1163" mass="126896" checksum="FA8C222A7EB66027" modified="2025-10-08" version="1">MHPYGKLPQSQGTSNATSPPPPTAAPANGPPPNPLRPSYGLVTDRDRDRERQRNPYSYPSPLQRPDQPSASSSSHLPQQRHQHHHHHHHHPSSASSTGSTPRDERTNPYIPPPPGASAGRKPDMLGVGLGAGLGRLSGGYGLFGNSPFREQEMRDKERQERIQRERERDLKPPAPTSPTQRASISTTPGNSYPHPSLPPSPTNTIRSGLPASTPGTGKPSISPQLPPTSAGSASGSRPSLPLPNFSALGSRSLPSPFERDTGERSTSGSAHPSPAVTSTQEVPPAVAGHARSLSNSSTREIPGLPGNEQSPPKPSAPSTARSLYASGPPPLSGSKGNGTREIQRSPVTRAPTAASPREPPRDIISPSVAASSAKPPPSQAPVAGGPPSGAPASGRGPYTSSYAYPSNPAYAGSFGGFGLSSFGGYGAFGGPRWDHDREREAREAREARERAERDGRRDEEDKRKKEIERQREKEREEREREKWKAAREQDQRERERRSSLSTPSAAPSSGVAAAKPSDPYRRSAGLFEGKPSSGYTRHIEVLNHPDPSAQPVTAPQNATNPGYERETSVIQQVAPTREPRPYGYKPEPVARETPPAQPPIREPTANQMPRESLSSTASRESRPEREYYQTIPASAPVAPPIPVTVPVHPPREKRSRMDAVVEDAQVAHQAQQAQRRSSQAKSKRRKVEEEKMTQAHHGMGHPHASYGTHHAHGRHSPMMDKCDFASLTQLPQKRLEVSSAPVEAWLKGLPSLSRVIGTIDYTGKPFTLAKTGLVKPENEGGVIVVRIGGGFLGRGWRVRGEPGWEDASTKQVGNVVCGAKDPERACWGTDVYTDDSDLGLILVHAGWIRWSALPSLQSPQDRKKDEQEFINVTVRLVPRLVRYTGTERNGLKTRGWGNGHDGSSVVVERVERVKIDRKYLASRKRKARISEWAHQRALVCPVPSSKQEDEEMKETILLTTTVPTESLILSSINVGRKDATVSGAFKYSPEVLKGWLDVPIEGDELEKSLWECKLILEGSGETYQISMNRESTYKHPLVNLVQLLPSDTEPKEIFASHPASGIYLLDEGVAAQIQGEKGMLFKVGKFRWEKLKEEEIGAWMKEEEEAVPAVEDIVDDVPVEEERESAPQDDKGEMAVDTPEVNGSNAINGDVHMKEEQMDVDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BME7</accession>
    <name>A0ABR3BME7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_105060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612166.1">
        <property type="nucleotide sequence ID" value="XM_066759519.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991916"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="402"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="402"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="297"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="560"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="873"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="507"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="732"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="811"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0243799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="916" mass="101595" checksum="D4DE722FC9B23429" modified="2025-10-08" version="1">MSRPTSSDSQHSGTMSSHSVLQNEIVHENNFMTTPTSASYQTQVYYADPYAHASFQHYQGSAYGGEVREHMITPYGGHQVAQGRIAMPMHGQPLHRSPNGAYEEFEFTPFVPEEETTPYLQVPERYHPMVQSPSMTMGQFSHPLSPVDQMTMEHHHFQQSNSMGNQPQQFIVQTGRPQRPKLQTSQSMIGPTRPSTQNSMQRLGMTRHASLRGTTRPDSPYVAGDVFDHVPGQLEESPVYQPIPPQDPSWELSAFEHHYANGQGISPARALGPAPTQPQRFSPRHDELMVTPQANKIAYSGHPPSSAISTAASTSSNFSVTMKHQRREFDSSDDEQEGRTRKPLPPRTVKTRQEEKLPPPPLPLPTRPPPKSASARAPIKPVKVAEDPGVEGIPPGPRSHERPGPSFACIIGQAILSCKAGGLSLEHIYRYVETAYPYFKSGDNAWRNSVRHNLSIHKMFETIPRTEKFPPGKGGIWIIHEDEKCHWPAQDKFIKNFPPGHPHHNVCRQTLHERQKEKDAMEKAAREGRVYIPKKGKKRRKQMLKEELEAEMAKRLAIEHPGAVLSEQKVEEEKEQTPEPVEQEIASEEPVVNEPEARTAPEPEPTAEVEIAPKPEPKQSTPMPPPAVKLEKWALPPPPVDPKGKRKQVESEDDPLFSNSKRVRLAEPLAPIHPFPQESVPGKAEKYDASFVTPERERPIPNGSKLLSSASDFKTPALVQSSSSPGSPPMPTTVTRPTHHPSSLQQAWTHDDMSQTPPRDSSPARPMLDAAFDLKPKSLRTKQVTQEDGFPHSHTDLASPPHPRGPPKTPVTRSSAAADKTQTPRLHHRKTPSMSTVTPVVFRDSPGLPPPSSSALLSTPMWEIGGCLDRLKDHFAPSPTSSIRPIRSPAPPTSPTRYAMMLMETGGSPRKGKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMT0</accession>
    <name>A0ABR3BMT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0244080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612447.1">
        <property type="nucleotide sequence ID" value="XM_066759800.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992199"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF140">
        <property type="entry name" value="PEBP-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047325488" evidence="2">
        <location>
            <begin position="19"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="939"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0244080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="976" mass="101395" checksum="52662CD303134A48" modified="2025-10-08" version="1">MLGYFAALALALPALAQSASNSSASAVEIEGLEANFKQAELTPQLLGTFQPEALLSVTFGSDTISTGDKLDQTAVSSSPTLTVIPASNATFASGQLYTVVMVDADIVGTDESTTQQTRHWLVNSASLSTDAAPHAVNWTGSTSITDYAGPGPASGSGSHRYVIVVYEQPSTFSPPANLSQAGTPLSTMSLSGYVSESGLGNVVTANYFQVENGQSTVTVSSTTAVDSSTLAGFLSTSAASSASGTASGAASKSAASSTGSSASSASSAPASSHSATSGALRSEIGFGMVVGVIGVVGAVLGAGRKGKKKEAPAEHLNSHANSHGLDYFLEKHTTDKVYENSTEGDRPLPVERSQGSVSALVARFQTAANREKEASEREKEKDRGRVSLGEGRRVSDVVPAKDAVGNVDSSSQPTTSASAKTVPIDSSDEKDTIKENAPQAQTHPRPPHASPNATSQSRIDTARVSPSTPSTTPAKSTVISSTKSSLGRASSIRTPARSTPAQIQGQSKANKPRTLSTQNSAKQTSVLPSPSRITSPSSTLAKDNNSTSTPLKPQLTGTPSKPTASSLAKTRSSPSSNPPSNMRMRSPPVVDDPTAARAERRSSSSFGRQDGIKSPLSSSGSLTGRSSLGRAASARLSQTKSPVATSTISRQRRVSENGSGSPQPQEEKKESRSVTEPIGRAAGSRLMQGTAASRARAAANANPHSSLISSSSHTPISSTSPPTSAKITRPRASISTPVSNSKKPMSNGNNDSSAKGPTPKSNPNDEEGNLGVKSVGKNPVGRLGLAAAREKKDENEDDKTEALHPPPIGRLGLAATRENPRTVKEKQERGNVVEPSEQQTHHMGAEDEHEQRVECEVGIGEKEKQKGDGTLSEPTGEAEEGLEEKDRQIDVEVGAGAGQSSSFTIDMKPQGVVTRLDEVEDGEETKCAGEPTEPLESPIEINVQQNNETNEVNEINETNETNDREDSEGEKEEGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BMW6</accession>
    <name>A0ABR3BMW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein transporter SEC61 subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104537</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612497.1">
        <property type="nucleotide sequence ID" value="XM_066759010.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991393"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="12">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0245413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="478" mass="51843" checksum="C2013AFB46DFC9F8" modified="2025-10-08" version="1">MGFRFLELVRPFMSILPEVTAPEKKVVFNHKIAWTAVTLLIFLVCSQVPLYGIMSSDSSDPLYWLRAILASNRGTLMELGITPIVTSGMIMQLLAGAQLIDVDFSLKDDRALFGAAQKLFAMVISLGQATVYVLTGLYGSPSSLGAGVCLLLILQLVSASLIVILLDELLTKGYGLGSGISLFIATNICESIVWKAFSPNTVNTGRGPEFEGAIIALFHLLFTWNDKTRALKEAFYRDRLPNIMNLLATVAVFAAVIYLQGFRIEIPIKSSKMRGQRGTYPVKLFYTSNMPIMLQSALTSNVFLVSQMLAGRFPDNLLVRLLGVWEPMENNPTQLSAVSGIAYYMSAPHSLTSALKDPFHTVIYIAFIVTACALFSKTWIEVSGSGPRDVAKQLKDQNMTLAGHRDASIYKELKRIIPTAAAFGGATLGLLSVVADMMGALGSGTGILMATTIIYGYFELGIKENAGIDASGLGDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNB4</accession>
    <name>A0ABR3BNB4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612466.1">
        <property type="nucleotide sequence ID" value="XM_066758979.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991361"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="29875" checksum="A31DDA82767134E9" modified="2025-10-08" version="1">MASILLGEPNSLPSDSTPEKRRKVPKVAFYVAGSAFALTIGLTAMVIPYVRQAAKTMNGPQFMSHRNLEHLASRRFPSPSSSYSASLPTPPSQTRASLQAASPSSALQSSIPSYSSASISAEIPVSEEDIKHLGEGSQPAVGSVVETEVSPETIKSRLFNAREEKALYGSSLMPLSSDTASKGEGEGEGDRMEGALLGAKALVIATTLVMGFTGLGMWVAGKAVGAENPADFAIKMRQQLILSMPQLVTSVNKPGRSTDGFDGEAIDKWVNELEREEVTRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNM4</accession>
    <name>A0ABR3BNM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I308_104784</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the BRE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612734.1">
        <property type="nucleotide sequence ID" value="XM_066759247.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991640"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 15 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="767"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="212"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="339"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="533"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAL0245650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="820" mass="92724" checksum="4B848018C826515F" modified="2025-10-08" version="1">MNADLKRVRENTLDDSPSPSAKRRLNSNASSPIQPSDDEGMAEWMKIVEVKRKEAIYRQMLEYRRTSERETKRANDLEAQRRVLEASFHAVELCWTQIVAAVRDLAGAEDLQLKEDEVLEPLLDPSTPVPELEKALQSRLPITTQLVTRFVDLVAHNATRPASEADLQARCLKLEAEASALRSNSKLLESEISALKGSRDDAQRDLQRTRKALDRERMEHSKAQEEWKEERTRGDRATPNLRANGSGHSTPNGKIDTEKKFYSGAGPSVVGVLQDTSELEQLAASRLKQLEQLHIERTQLQQEVDRLKILANHPSETALRESPFFQVYLHQLSTSINHAEALQTRFTATECKLDQLRDSNGEFREAVLAEARAQTEALRAQMAKKDSDIARLRGQRDELNGEIMERRAKEIEKCKYTEQIENLAKSRQERISFLTSEVRRLKGKLAAAHGSDGYLSFLRESGIDGDYVKDLEAKVVSSQDQINALTSQLERVSSDTATGRSETEVRAELESAKRLLAGYERILGPNPEAAEDVKYLSQQLEKKEKERASLEMRLEEAEAATNALYSEVEGLSKLWETLDQTVKSKVLELRDGEQKITRLATEKAKADNKYFAAMRAKEAVDMEAKAAQRSVEKQLRLLERAQEVEMSLRSQITANEKGLTALKNNALDLQNQLATVVAEKTQLELRLQQSQSALAEAQQIMHQRVAEASAEKEARAKLQDEADGQMKTIKKLKERQDAVAAASQTGMSDHEWAITQERDKLLKLLKCSCCEQNFKQQVIVKCMHTFCKQCLEQRIASRQRKCPACGLAFAKEDIQTLYWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNU7</accession>
    <name>A0ABR3BNU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_104885</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SPT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612833.1">
        <property type="nucleotide sequence ID" value="XM_066759346.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991741"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="9">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0245749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="113" mass="12634" checksum="703B7FC4BC376729" modified="2025-10-08" version="1">MPPKSGRAELRACLVCSILQSTNDFLTQGCPNCEDILEMRGSAERVAECTSLLYDGMIAMIEPSESWVARWQRIDKRMRGIYAVRVTGRAPQDVIDAIEARGGVYRPRDAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNY5</accession>
    <name>A0ABR3BNY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetyl-CoA transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_104517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612478.1">
        <property type="nucleotide sequence ID" value="XM_066758991.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991373"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0245394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="66377" checksum="9A83E72B17465A5F" modified="2025-10-08" version="1">MSVRGHDGKGVHTAATTARNNMIHRENNTIRPRNVEDINELEEKGLLRRVDDDSHDTSPTRRRAKGREKETRLEKAPVETDYSTGLTTRRDKQAFALLVLLLIDLLQGIPLGLTFGTLPFLLKSHLSYSQLAIFALSTWPYSLKLLWSPIVDAWFVRKWGRRKSWIVPIQGLVGLGLWVIGGKIEEWLNVEEVDIKFLTAVFGSLILAAATQDIAVDGWALTLLSQPNLSYASTAQTIGIGIGNALSFTVFLAFNSVEFSNKYFRSPSQPLDYPLISLGGYMRFWAVVFVGVTVGLAILKKEDPPSEDDPDMDVKKVYKVMWSIVRLKNIQTFLFVHLICKIGFQVNDSVTSLKLLEKGLSKEDLAVAVLLDFPAQMAIGWLAAKWSRPAPSSSHALTAGGGGGESGNILKPWLYAFWARLAMAAISTFVVAGFPSNRAGSSSVGTTYFLLVIATTLFSSLTSTVQFVGICAFHTQIADPLIGGTYMTLLNTVSNLGGTWPKPLILRAVDMLTVATCSPPSSSTSWGSKFSRSFPSSSSDVGECVTEHGKNLCAQAGGECIMQRDGYYIMSAVCVTLGAGLLVVFILPMIRRLAALPMSAWRVKIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BNZ6</accession>
    <name>A0ABR3BNZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_104928</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612876.1">
        <property type="nucleotide sequence ID" value="XM_066759389.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991784"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF301">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="158"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0245792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="458" mass="51974" checksum="9CF20FD1FA3A3A19" modified="2025-10-08" version="1">MTISLVWLFQQLIPPLLLTYFFLSWRVLTFELAPSLSLNVLTWSQSDSGHLSIFTNGIKKIISYSIFFSLHVLPTLLIGTVAILYLRLYLLPSSQSVPPFDPPPEILNKQVMFACFFSQSSSRSRYNSEPESEYGDVLQVIVQEPEVERCYKGRCGGRWKPARTRHCTQCGVCRAGFDHHCPFFANCLTAPYIPTFLAVLLYTPPTVLILSLPLLLPLFHRSIAAYTQACDSSEIIAHWWNWKWSWVVAGGPIGRYAGGIILGWRELDRQDGGGLYRLAVGLLIALGFILSGITAGLAYSTIQVLQNGDFTIDRERSRAQRRILSTIKDLPTRQPIPDELRQDLARFSDRPAFYLPPKNLNQLCPQDQNRKWDRRGRKHSNGCIVQLNGNARPYDHGPRANMQLVLGAPWGEEWGWLLPWRAIWGGIEHDRGESCLFNWPVADGIAKEIEGVMESWDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP28</accession>
    <name>A0ABR3BP28_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_105616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000010">
        <property type="protein sequence ID" value="KAL0243648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612015.1">
        <property type="nucleotide sequence ID" value="XM_066760069.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992471"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049874">
        <property type="entry name" value="ROK_cs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="719"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="825"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="825"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0243648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="99920" checksum="AD3F059648D005C7" modified="2025-10-08" version="1">MVSSDAPPEGRLTSNSLASGSMQPPAVPTRRTSAAESGKAGGKADKGDKEKSGRQSFSCAECRRLKLKCSREWPCTSCEKRGCAQICPSGEMRTGKGKRLILADTAELHQRISLLEVALSQSHAKTSSTPHPLLKSPYLFSPREPRSYGRNNFKFNGSGSGSGAEDELLQGAFGTLTIGKEGQATFVGSFAGSEYLREDGSGDELVEPETGPDVVGGENAHGHTATGERQKALAAPPATAEGRWSRNEQDNSLPRLGLYSSLFGGGEVKHDLEKLRDELPDYDSEGKALVMSYWENVNWQYQPIPRAMFENDHILNAYDTESPPTAHKLACVFLVMALGSMFDLNRPPFHPRGEQLFMLGRACISVAGIEQASPATVQAMHLMGTYILNDKHGNGGEVFWPILGTAVKIAQSLGLHRDGEHYGLSQYEVEERRQVWWEVVSYDRLQALCFGRPCSTSYKWSDTKIPEVPELIGDETGFHRAKYMLMNLMERVIDVQTQVVPVSLTIVSQLDSDLREYKKNLPELLMPNVAISDLPLDPNVHPHLVIHRFGIRLQIAQMRLLLNRPLFARALKDAPGDPSHSKFGSSFVALFENAQEIIHLVKALVIYHPSLVARWWFFWFHAFSSAVCLAAIAIRAPQCAFASPSFHAMSIVCDISAAAREGCRAKKGLPILLRLRKRAHEALVAESRTKNKVAADGSGEEDDLSHLVGSAKLRRVQAPLRRRSVSSSNGTGVAVGTGMTGGVDGTPSPSSGGSIATASTLVDNGLYEGVVPAFSGNQTTPSMGNCYPASSYSLMTSSWGSEDCLNGYIPNNLVSRSVVDPGAGTSRNTWPNVSNSSPSTNIPVSPEYERQMGVDMDMSMALGMNMGMGIGGGLGMPGQHFQGDEGGGQMGHQDGMAGQGAEDQDGDMFGFNFEAFINQMGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BP29</accession>
    <name>A0ABR3BP29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_105980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611733.1">
        <property type="nucleotide sequence ID" value="XM_066760429.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992835"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0242351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="113" mass="12765" checksum="3C4A2F10ECC67CC6" modified="2025-10-08" version="1">MVALSSPLHRDSQQSIPRRLSSKNDRGLPNGAPHISTTSSPTTSQSSTEDCNFEVEGLSTSETLEKRKRKYSEKLYQWTQEMWNNTKRDIELGSSISSSEDSSDIYKAYNESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPE0</accession>
    <name>A0ABR3BPE0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612643.1">
        <property type="nucleotide sequence ID" value="XM_066759156.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991547"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0245559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="286" mass="32292" checksum="EAD4D5F513E66EA5" modified="2025-10-08" version="1">MSSVLSAIWPFLSSYRPNAARDRQAQREKQPLRFGAFEATYKPPGFGIRSPRNDDEAQRLYNHIRTVAYWLDAAPLLADLGLPFRAGLDDIISLIPIYGDIVSGILQLYQVWLCFIFGVPRTILGYMLFNVLIDCVVGIVPLIGDFLDNLFKSNLRNLALLEDWLLTSPAATRSYHILLMPNTTDFIPKPKASKYSTSWFGGGHGKSEEDEEKKRERTTGKVRQTRRMGRDEGEVPQAQSDVPPPEFVHAFVNSPAHNCNHATAIFFWTGAERRMNAVMIFAPQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPF6</accession>
    <name>A0ABR3BPF6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
        <property type="protein sequence ID" value="KAL0243768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612135.1">
        <property type="nucleotide sequence ID" value="XM_066759488.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991884"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="942"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
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        <location>
            <begin position="650"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="818"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1058"/>
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            <begin position="1071"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0243768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1142" mass="125729" checksum="6C3640CB7F282FAD" modified="2025-10-08" version="1">MPSLFQSPSKMSLKDVKGPFKKRRLSTSFISPPIPVSSLPSDRPANHSDSRVNGNNRGWKDDGTWEKLSEIIKLGPAFPPPLPPKSPSPPPVPPKSPPLSLPPPSQSKLPPQTSYSPEKSLPKSPTKNFIIKMVAKSVSMPSLHSAANLRGNENAVRRMHPIEGAEAKGKGHVKNNGRVKYKDKNTKESSSKAPDESKGYHRWKKKEKTEPTSKSQEKEKSPKQGILKFGKKEANPTLHSNSKSEIMEKKKSKGKVMQEVPRKVRFHHVPPTPPVSGSSNGSSDTRRSRGGNATVTAESLRFPIPAVLFSDFGNQSVDSMLDQMLAAQANYKPASPIAFPTAVPTPLEGTNDVSSCPPSEEHAQLRSPLYNRLGKSEKSTFPSSSSPLISASMPCSIDTYSQACTHTSTGNPVSDFGAGYGSISSFPSAEGFAIPSLSISDRLGIETEGINRGMSSMENMPNALDGAIHDSLQSQGMPVISVELIDDEVHGGNSYPHLSSKDNPQTILSSTHSNNITQWYDVYIHHKEPASPALSAVSSSAVIGARPPSPPSHLSPYHSSRGHPSSVGNGNDPRGKFSSIFELISKIDNPKRSELMVDFDIGRPYDEALARVSSGTTPISTRTDGNTSAKRKMSSIPSLPSRNHLKQPHNDNSSTLTPVISPSMSESTAEEILLTPIDHCLRGHALHSMTKISRSAEGVSGGTSGDLLTIEQSLMYRALFARAFQRGFLTADDLRGEKIHIEALIPGGHWSKVDHGVAKEMVTLRRENARLKVSISSSNSKGWYGWQMIANDKCLRKTQLAVSEDIVESQRAELSAFLNSPPSSYSQDPCSPYSSPLNSPSRKQGLKITTDSPNITPRRLPYINSNLAGSPTSRNAKYNNRRSPGVDYLINEVCQLRTELEITRDRQEQWQHRAELEETHRERAEESVAAMQAMFGRVMEDLDEARRRSQMTRTKNEKARLEMEEKRIKGEMTKLELRRRSDKDLLEKEKMKVKVKIMEKKIEGYNEAVRMFKHCLVEVAQLREQRSGLEQELFHLRTDYDHLSLSTTASVNSPSAHSLASFPETKGHPHSQMQHIRRPSSNNISSYEEDGKEKGSLTPVDPTTSKPSQSFQPSTGVSKASVGQSRPSFWKFPLTSRTQDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPG6</accession>
    <name>A0ABR3BPG6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613042.1">
        <property type="nucleotide sequence ID" value="XM_066758594.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990972"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="733" mass="81046" checksum="5EF0F7EB3D1E16BD" modified="2025-10-08" version="1">MDRADWTRVSGVNANVYNPCLADTLALATKNRGHSKQSLNAKYDQILGSVRGRTASLFAKEPEIGQGRDGKTFAGPSLIPSPQSYGVGSKLKRASLASQTRCAFPTHRNGGIFANLISARPVILQQPPPCSPTLSDYNYNTGPSHARNDSSNLLYTPKTDAFEPDSYSTPYVDQQIGSKTEYSRGIGGCAQPISGFASFAHPEDMVHLPHNSSPRSHIYQPSSPSPRPSMTLAEHRVRFQPSHQTQFYSPAPVHLPLSSNMEFSAFPQSSEAYQSHYGTEEELSDFNFAPAWPQPAPTPHQSPLPMAPIFSAPSAPSLPECRFSPVPVQTSLADLAPAATSSDLSSYPNLTMSEIQSPITTQSIYHTDSTISVASIIPQSLAQAHQDILLPRQKKKQKRRDIQQNHYKIKGKEAIRFLEDMAESLSEGEIDPSPLPMPSEVPSDRWCAQAWVPTFEQPLIAYADPFTPEEDESGPSSDTCVASCVADTIDSPHTLVTEEINNASPTSLEKDDVSQDNTLKGMDQDFPQQPHSKNKGNQRKLLKEKLRNRVPTPAPPPKYDSEDEQTAHESESELQLEFTQFCQDKAPNQISPARRLFKSMSDHKFKFKVPFQTAGKDGNSSESSKKMVPFKRKKQPSETSSITEQQEDIEDFSEDESTRPAEMIKEDPTEANDMGKEGKLKPAKAEEGKANGTGTLDEKQDEKDAKYREGKRWVDEGFFNTDGGELGFRIWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPL1</accession>
    <name>A0ABR3BPL1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_104162</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613088.1">
        <property type="nucleotide sequence ID" value="XM_066758640.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991018"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="9">
        <location>
            <begin position="28"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="203"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="274"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0247127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="466" mass="53491" checksum="F217F1111BDDC79F" modified="2025-10-08" version="1">MSAPSNKSGSIPSMEASGEALKDETVVIVLGASGDLAKKKTFPALYALFAQGFLPKDVHIVGYARTKMDKDEFHKRQVQYIKGDQEKIKQFQELSSYVSGPYDQDAGYQELLKHVEELEGDRETRNRIFYMALPPSVFTTVAKGLKKNCYSTRGTNRIIIEKPFGKDLESCRQMMSELKSEWAENETYRIDHYLGKEMVKNLLVLRFGNVFLDASFNKNYISNVQITFKEPFGTEGRGGYFDEFGIIRDVCQNRFVDTRYGTTRFFFCRGYPGREGYLEDDTVPKDSKCPTFAAMTLWINNPRWEGVPFIMKAGKVEIRVQYKDATQGIFMDIPRDELVMRIQPDEAVYLKMNNKLPGFHTRAVPVELDLTYKKRFTDANIPQAYEALILDALKGDHSNFVRDDELDVAWKIFTPILHWIDSKDAPKPEPYPYGSRGPKEIDEFTAKYGFKRSPQTYSWPKTSANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPR6</accession>
    <name>A0ABR3BPR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613148.1">
        <property type="nucleotide sequence ID" value="XM_066758700.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991078"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="313" mass="34379" checksum="BB5B09EEDAB32693" modified="2025-10-08" version="1">MSPSSSLSSAGGSSRGSSPFSRAGTPDVDALEAYERLMASIIPPSTLPRPPTPLLTSKLMLSKDEEGEDSVMGENGVKRPMTKAEKQNAKKKRRKERERAARMEAEAAAKAAADGVEKEQNTANDSLIEFRLFSSCPVKPISLLPPSEDYPLPLNPRRLPLPEAKIQNIQKAAAESAVEFSSLGGPSCIHERWTRKHMSPREVLRESPFEEETPCMFIGVLSRPPASLVGSVTTFSNGKSIPVVPLKTSETSIKQSLTTKRTRRGRRRKTTAAPRFWAPPAGMGGKARGYAFGYRDSMEGRRERGWHGYLRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BPT0</accession>
    <name>A0ABR3BPT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_104237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613163.1">
        <property type="nucleotide sequence ID" value="XM_066758715.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991093"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="226" mass="26057" checksum="A34901B790A394F1" modified="2025-10-08" version="1">MPGINYVSSSLNRTKRRWSSQADEEAYPRPPHGYVRRKPRGMFAYLKPPPPLLREENDEVYDDAEGQIQEEELELHETSQKNERQEDPRQPTPRKPIIQPKVNTQSIDFGFSWAVPLSPAQQRVKAPFGNSGKVNNSGEDRLPSAHSLPWFMVWEDTWIGKADSQSRGREEKPQHYHSTMSSPGRRVREILAKKNFSQLNLSLRPSQSHTQSPYKIQKKSNLKGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ88</accession>
    <name>A0ABR3BQ88_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0246997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612958.1">
        <property type="nucleotide sequence ID" value="XM_066758510.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990885"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0246997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="169" mass="19288" checksum="5A5825B24E9E7A61" modified="2025-10-08" version="1">MRLLFIRQLVNSYVQVGTIHEWHNRAMTVIYWPGPFFQTNFLSIFIKQCKTLEIMAPVTRKSTVAPRRKLEVLLPARMRRMPTNQNPPIMQSPPSPAVPPSPAVAILDSLIQGNLEVFQDQELCLSANEYIMADAGFNSDNRVATMYRRTAELSGRYPEALYLISDSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQ99</accession>
    <name>A0ABR3BQ99_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613325.1">
        <property type="nucleotide sequence ID" value="XM_066758877.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991256"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031">
        <property type="entry name" value="SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031:SF3">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="464"/>
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            <begin position="43"/>
            <end position="61"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQB9</accession>
    <name>A0ABR3BQB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000009">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
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            <begin position="19"/>
            <end position="196"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL0244068.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="196" mass="21382" checksum="12806522D0C7E081" modified="2025-10-08" version="1">MRIFTVLLSFGLLTFSIAAPAPQPKVPSFFFKDPLSIHRRSSIPLPVTGDDEQTNPSNKLLAYDLEVEFIEDSDPAHLTSSSSASTSSSSSKNVVVETEMEAYEVEETEAEDTCANVCGVTRVEGAKSEHEALCSPAGLKATYACAQCIDKVWNDITWENSALAEYEHIASACEGVNRAQRPIRRRNGLDIHSDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQC0</accession>
    <name>A0ABR3BQC0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">I308_104075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613003.1">
        <property type="nucleotide sequence ID" value="XM_066758555.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990931"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="156"/>
            <end position="165"/>
        </location>
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            <begin position="320"/>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="429"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL0247042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="563" mass="61367" checksum="DD34049B30C65B86" modified="2025-10-08" version="1">MAQPSPSYVPRASRPSSPAVAPTSSAYVPRSSSTSRIDRGALTPRVPLERKSSGLRNEMKRESTQEAQEMSEDAKCILKLLSNLPAPLPESLPPTFLPSPSASPRSTSSSSPPRTFTEYVHLKRKRDLEPDESYGTKNSGDSSGIGLGLGLSVAPDKKRKVEDTRGITPSSPMLNGLYKKDKARSGLRNEVDVEVEEGEVGGDGEERVRRDLWKPEKWSQMGTWYRDRALLLKRHGDAYLRAPTAKPDFVRSLPADRLKGLLCLTDSALLYNYSHFCDEKAKAKPLPGIYDSSSGLRTFVRKEWEHEMRRGEGSDGEEGGGSKEKESERERARAMAGLMYLLEAVIMYQTGKDSLAVLQHRGKELHATLASPHDNPSPPGFIATPSPTNPSHNTSTTITASAASASVTAANSNTGVANHSSAQPPNNHSPTSAHSSAHSPSSSTSSVLPPDLLPLIFNSFRQSSEATQYLHVSRFHLTLRALRHYFPTSYGNAIHSKLADQALPAPGDSLGAAREVDPDRPARFAWPIEMGMCAPVAHVVAFGRGMVKEMAEREGRDWKLVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BQZ0</accession>
    <name>A0ABR3BQZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_103687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613571.1">
        <property type="nucleotide sequence ID" value="XM_066758169.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990543"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17231">
        <property type="entry name" value="TGS_DRG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="62"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="289"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0247610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="40884" checksum="88BF53DA5FD06C28" modified="2025-10-08" version="1">MGILEKIDDIEKEMARTQKNKATEYHLGLLKAKLAKYRAQLLEPEKKSAKGEGFDVLKSGDARVCMIGFPSVGKSTLLSKTTKTESVVGAYEFTTLTAIPGVLEYEGARIQLLDLPGIVQDAAKGRGRGRQVVSVAKTADLILLMIDATKSAEQKRLLEIELEAVGIRLNTRPPDVVFKQKQAGGITLNCTVKLTKTDERTIRSILQTYKIHNCDVMIREDITTDEFIDVLLGTRKYIPSLTVINKIDGVSMETLDKMAREGDGRTIMISCEIDLGIDWLLEAIWKELGLVKVYTKRRGEQPDLNDPICLRQGATIETVCHGIHRSLTSHFKYALVWGKSSKFNPQPQKVGLNHLVQDEDVVSIFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR06</accession>
    <name>A0ABR3BR06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613583.1">
        <property type="nucleotide sequence ID" value="XM_066758181.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990555"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="282"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0247622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="460" mass="50126" checksum="DD21E377784244CE" modified="2025-10-08" version="1">MPHNHSLSTSSADFGDFNSAPASSAQTSALSQDDLLGSYDETIRYSPSLKSLPSPTAGASNLDLLLHDHNVEEHRRPEPTYSRPSRPTGVPPDHIPYVRSPRRLSTFSSTSPTSPPSITEAGCDIIFHPSYDHTDDNATRAMQKMQGHGEKLSDKMQLRGPASHSHIALTSSPPHSKLLDTLAATTKMASKWRSVITHPTPPSSADRTQNGQPRPHVRHSETSPMDISHDTPFASAEQIAGSYIPPTGAPGFTQASAAGQKHHGDGTFEHLALIGRKNSTSNVLTSEDAVGLRACLPPRQRLTNQWTLLFSLDQHGSSLSTLYRLIDIYAVNHQSSGNILVIRDGQGNRFGTYMNEPIVKREGAYYGSGESFLFKLTHSCQTIPYRWTGKNKYFALCEADFMSFGGGAGTYGLILDSTFTHNSSATCPAYNNDILCELEPLKSQNARSFQCLGLEVWSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BR86</accession>
    <name>A0ABR3BR86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_103786</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613669.1">
        <property type="nucleotide sequence ID" value="XM_066758267.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990642"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="95"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0247708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25819" checksum="25AB8B89149ED483" modified="2025-10-08" version="1">MPVSHLLAKPTTSRAGAMLTMSLTRPLRLPLALSIARNARSFHATPKRGISHFDTYSFVEKLENNGMTREQAEGVMSVLAEVIEESIKGMEASLVSKAEQEKQRYTEKVDFARLKSELQLHEKNDLTLMKAENDRLMADVEKLKQRLREEVTRTQAGVRLDLNLEKGRIRDESSQQELKIKEVDTRIESEIAGLRTQIEQAKFSILQYLVGVATGSGALLLAYMRMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRB9</accession>
    <name>A0ABR3BRB9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613701.1">
        <property type="nucleotide sequence ID" value="XM_066758299.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990674"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="42172" checksum="3551D687EC3B67E5" modified="2025-10-08" version="1">MTRSKKGGRSSTGSKKAPPPPASDQPHDAASLIDKAHTLLAQSNFELAIKFLERALEVEPTHAEAKELLGIAELEGGDAERGRECLIQLLPPHVPEAPTHPSPYLYLAQSAENPQEALGYYTTAAAMLEKIIGGAEVNARGKGKQALGVEEVEDDVAEERKMAVNALLAMIEIWMSDLCMEESAEGNCDALISRALSILPNDPEARLSLASIRMSQSRFDEAKAIAMGLYNDFEGREPFDPILPPLPARLALARLLLEHHEHLAALDIVSTVREEDILNVEGAYLEGWALYLRAEALIENPALIPADPAPTSTPGEEHEEPEEPMSAAECLSEAMRSLIECAKLYADEDYLDEGIGAHVAELLEELEKKGVTPAMNDVEDDEDVEMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRF3</accession>
    <name>A0ABR3BRF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_104268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613194.1">
        <property type="nucleotide sequence ID" value="XM_066758746.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991124"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0247233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="504" mass="56282" checksum="A4CB3B047677D107" modified="2025-10-08" version="1">MVMGDTERLSDVTKLSAHVTRILGQNPGLMTLQGTNSYLLQPPSNPHAPLILVDTSSPHTAAQYVDLLLVHLHHLALESGVRETHFESSAAQASLRNFKEERRDEVKKIIREKRGAEPRADELGLTEYGPGSTWVKGYEGKTGVRKLPSIEHIILTHRHLDHVGALPLLLKTLQENGCPAPKLWKLPSPDEAELNRSERDRPTSDSSIWQSLPPGAYTPLSPLQPFHPILPGLMISIIDPQYRHLLKHDENGKAKWNEVPEIARVSVRCLKTPGHTADSISLVLTEGEKGVFTGDTVLGQGTTHFTDLSTYMTSLRTLLALKPRVLYPAHGPHIPSQEASISHIQTYIAHRQKREDEIVATLKRFSPFLDVEDGGESIADALITLKKDIHQKKEAENKAKGPLMLDKQNAVPLPDFDEERKALKQIDAWKGVSMSVIARILYESEDERLLFAAAKNVNAHLDKLIKEGKVRKDRVRMCRLIGDEIGDVEEMDGWEWVGEKGKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRI2</accession>
    <name>A0ABR3BRI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_103883</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613766.1">
        <property type="nucleotide sequence ID" value="XM_066758364.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990739"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="62551" checksum="BC36435932132238" modified="2025-10-08" version="1">MSTGNEQLTNRARNRQTETSKMQSLETSIPPPITPQHGIKKGKLSQDLQNGVRSSFDFSLPSHPNYYKFAHKLSPGWLFGRPVDDSDIQYRSFRSNLLPLVVLSCAYLVTSSLQARLAPSPSSRARFIALFSAFMITLLHGTSAIKIIALLALNYHVSKFPTSPLIRKLWPWLIISGNMMILFFNERWEGYKFESLHADLGVLDTYSGLLPRWHVSFNITMMRLVSFGLDYLWREPSDNTSPPAEYRKRVQASAAEQDYSFINFMAYCLYPPLYIAGPIMTFNDFLWQLRSPMSISVREKLNYAVRFLFCILTMESVLHTMYVVAIKDTAAWEGDSPSELSMIGFWNLVIVWLKLLIPWRFFRLWALLDGVDPPENMIRCVANNYSALGFWRSWHRSFNLWVVRYIYIPVGGSKNVIPATLLVFTFVALWHDLSFKLLAWGWLVSLFLVPEILARKLLAADKYGAHPLYRHVCAVGAVANILLMMTANLVGFVLGLEGTKHLLHELTSTVSGWSFVLFASSCLFIAAQVMFEYREEEKRRGIDRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRJ6</accession>
    <name>A0ABR3BRJ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I308_104937</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IND107</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612885.1">
        <property type="nucleotide sequence ID" value="XM_066759398.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991793"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="12">
        <location>
            <begin position="68"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="13">
        <location>
            <begin position="259"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAL0245801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="357" mass="38162" checksum="B1F8153C3FBD3EDF" modified="2025-10-08" version="1">MAARKYKIHVPCTSANIGPGFDVCGIALSLSLSLVVTIPSATPNAEPLPKIIYTGLDSDNVPLSPYKNLLTRVALYVLRANGITTFPPGVAIEAHNEIPFGRGLGSSGAAVIAGVLLGDLLGNLNLPKSRLLDFALMVERHPDNVTAALIGGFVGSYLRELSPQDMSAASIPLAEVLPEYPPDAGPDWGKSPPQPPHGIGHFVRFGWAKEIKAIAVSPRFELATAKARGVLPESYSRKDMIFNLQRLAVLTTALARSPPDPDLIYDAMGDRVHQPYRMTLIPGLPKILSTLTPTSHPGLLGICLSGAGPTILALATHNFEAIANEIERIFADEQVLVDHKVLDIDEKGSWVEDITEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BRW3</accession>
    <name>A0ABR3BRW3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_104788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000008">
        <property type="protein sequence ID" value="KAL0245654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066612738.1">
        <property type="nucleotide sequence ID" value="XM_066759251.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91991644"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0245654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="106" mass="11985" checksum="2CC39C075131AE56" modified="2025-10-08" version="1">MSKAPNKPPKIEPSHIYLQISHLPSQIPSTTLDNPPWQLKYVGQVGELEGEGIFEVVKSDGQPVKRDESLWIQGQKALVEKVKDAQGVKSVKILPEVKRRTKREEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BS09</accession>
    <name>A0ABR3BS09_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613771.1">
        <property type="nucleotide sequence ID" value="XM_066758369.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990744"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="869" mass="95992" checksum="879843381731DB49" modified="2025-10-08" version="1">MQPHQSSEGEQRMLDNQVDQFTNFVTTAFPIAGARRTGSLTQAAPPISQMSEEELERHQRSANGSTPGQPYHNIRRGVFPVPGDRRAHAVVSNAPFDGYDISNASAGPSQIQQTTSQSSLAATQNPSQPLPPGSDTDPIASFLAEMPTEAEDPTRHVLWTELIRLKTRSLELQIAEARRKEKEAELELARLQSGAASKNDNENGKAMAGSSGTAGAGIPSGTSYVLPQQHMAQQQQQQQQQQQQQQSQHVQPVPQEPTFNPIQQLYSGVTQNQSQHAVSPFDLDAMLQTDLTNFLSWLPDLGNNEGVQADGLQNTSDSNIPLGTLQPPSIFGNSTAPQHSPTRRASHSPSNSPPPAKRSKRTIEKKTVVEKPSACIICSKPLARVMIRAPKSRVPDPITVSLKCPQCAPVKQPSTLLDSNQASSATSSSIGTVETRKRMRASMEIDDEEAKVTERRTWCDVCQRIVGSGQVWGGKGRESILHQAEIICTGCDSKYQRCTDCGGGGGPRVGIGKWRMKQVFHPGRKTCSLSHTRLGDRTRELGVHVTPTDFTPEQMKEVLSRCKTLWNEKTLSRLAIPEMLEVDLPASLANPLRDFTDVDDIVTRNWPSREAMIRADGVNPSRFKRLLSLIWAHSKPRRSVRTVDLEEEWSKQADENDEDDMSTVLANVKRTNVVIPAGSELIGMWGGEWDMQNGSLLISTFIPFEGTDGEDSTALSVGEMITKVQGLQQEINAERIARAKRDGTEPELLPPCQHLWTVSGGYIPLVRERFADILIRKRAFVHVEEYLTRHPEFIECIKARPVGLHPDIHRPVPHPDASESSADDQSAPRPLILVRWLGKDFDAEKILEIKQMEFGGGKAKVKKRLRSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSF7</accession>
    <name>A0ABR3BSF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_103182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has a dual role in the assembly of mitochondrial ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614066.1">
        <property type="nucleotide sequence ID" value="XM_066757682.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990038"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0249879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="227" mass="25875" checksum="74E6A544BCB34E52" modified="2025-10-08" version="1">MSDKPTSSPTEPPEQSAAFEKWRSGLAQFTGLGLSESEKAERERLKAQGKLEKDWDKCEGWKRQLVNYSPMITFLLNHLKLAGCPFPSSALQCHPCPENRAGGFSPDHGILLCQDRFFNKKHMEDTLAHELVHAFDHCRFKVDWGNLRHHACSEIRAANLSGDCRFTREVKRGFYAFNKQHQACVKRRAILSVLANPACTSPEMAEKAVNEVWESCFTDTRPFDEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSI0</accession>
    <name>A0ABR3BSI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_103222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614106.1">
        <property type="nucleotide sequence ID" value="XM_066757722.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990078"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0249919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="310" mass="35236" checksum="51DE39E1151B384B" modified="2025-10-08" version="1">MAPFDLDACIDRLRNKQLLGEALIREICEKTKEVLMRESNVVHVSSPVTVVGDIHGQFHDLIEIFRIGGAAPNTNYLFLGDYVDRGLHSVETMSLLTCLKLRYPERIQLIRGNHESRAVTQTYGFYLECTRKYGSPAVWQYFTDMFDYLTLSVVIDDAIFCVHGGLSPSIHQIDQIKIIDRFREIPHEGPMADLVWSDPDPEKEDFAISPRGAGYTFGASIVKKFLHLNNMNHVLRAHQLCMEGYSVLYNDQLSTVWSAPNYCYRCGNMASILEVSPGGRRFFNVFSAAPENERDGPSQQQPGKQIEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSN3</accession>
    <name>A0ABR3BSN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_104080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000007">
        <property type="protein sequence ID" value="KAL0247047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613008.1">
        <property type="nucleotide sequence ID" value="XM_066758560.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990936"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAL0247047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="159" mass="18310" checksum="17FCBE5060985040" modified="2025-10-08" version="1">MPPNLHNLLSSLRSPIFNTISNPTSARMGTKYLRRRLRGPSVASYYPQLTNPFPKLSLLNKNIPENPFAGWDGRKLPSVIKTKKGKVLYENIEWQNEGAMLRKDEVVERGYEEVARRKGLGWLEDPIEQKRIVRVAKKKRFGKGPPKKGQGRRSQMKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSN6</accession>
    <name>A0ABR3BSN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_103972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000006">
        <property type="protein sequence ID" value="KAL0247894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066613855.1">
        <property type="nucleotide sequence ID" value="XM_066758453.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990828"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0247894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="110" mass="12841" checksum="C59413C033A4B266" modified="2025-10-08" version="1">MFQTQPPSPTKSQQAPKERKKWNFRDQEFPRVTPTATVLCERRLNETYANRKVQIHTRNPFRNPQPTTHPLLFHLVTYRITSPSLTSHPLALRFTPIAPIQIYISAFSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSU7</accession>
    <name>A0ABR3BSU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter particle component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_103157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0249854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614041.1">
        <property type="nucleotide sequence ID" value="XM_066757657.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990013"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0249854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29738" checksum="7F8E8C29B6FE0104" modified="2025-10-08" version="1">MSRPSSTSTHIAIAPTVPPVLHILANPPPTLIDVQLPGYLLPPTFDLLRESSAHVIRKKKKEEDELRSEGLLPPLNEKDAKDESRLIEEELSKRIERIGLMVGGFIAEKLTLARPPISAHLDIIKFICKDLFLYVYSKQIDNLRTNHRGVYVLQSNAFPPLVPLSSYKGSAADMDAANTHLIFPQALIQGALHRLGMNAVVSAESSSLPQCTFQIRTLKSSNVPSTPMGGTPNPQPTTQRQAPVPISAAGHGQAAPGSPVMNVAGNSSTTGLGINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSX2</accession>
    <name>A0ABR3BSX2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_103357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614239.1">
        <property type="nucleotide sequence ID" value="XM_066757855.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990213"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0250052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35294" checksum="18215FA7CF3A43A0" modified="2025-10-08" version="1">MSQSQPPTSDDVDIVRTFDSSKDERMVKMIVGQGVMEGLARANNKIFTNPLALLFVFLVGMGINHISSFSVTSNPLSYISPLIGPCLALLPLMGIVEYIHRPQFTARMRKVIGAVDMIKPSAYYAEGKSGIWVFQHKGEVVGVVCLDATKSAGKELGSVLGEEEGQLNEKDIDNDLIPRKEDEKAKNAPDMRRRITRKENEPSSRIAEIRHLDVDQPYRRSGVGSELVLVALDRAFSISSDDLSSPVDRVIVRTNPLSPDGGKLFIKCGFKPITQIEASAAAWEKNGKIGLLGWAGECLSVDKDTWVIKRKELLEQARVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BSZ5</accession>
    <name>A0ABR3BSZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_103380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000005">
        <property type="protein sequence ID" value="KAL0250075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614262.1">
        <property type="nucleotide sequence ID" value="XM_066757878.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91990236"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0250075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="127" mass="14616" checksum="7D5BCE30977144D7" modified="2025-10-08" version="1">MSAKPSSSTQTTAPVVVSVAPSRNGRTPGKAHKSAKTALRRSYISPSVKTPFEKRMEKEKAQQAAKQLEKELKEEKETDRQRKINIIKERRARKEEKQREEELRAKMSAKKLQRMKKREGRSKKING</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTE2</accession>
    <name>A0ABR3BTE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614405.1">
        <property type="nucleotide sequence ID" value="XM_066756936.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989248"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="4">
        <location>
            <begin position="179"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="452" mass="49801" checksum="9864BEEA1EFC9058" modified="2025-10-08" version="1">MSGLKITEFSVHDVRFPTNVTGDGTDAMNKECDYSAAYIVVKTNSDLKGQGMTFTIGRGNEIVCFAIEQVAKRIVGMDLAPIFSDMGKFWDFLVADPQHRWLGPEKGVIHLATAAVSNAIWDMFVKATSFRYITDALTPAEALEMLKAKESGKAAREAEVKKRGYPAYTTSVGWLGYSDEKVKRLTKESLAQGFNHFKLKVGADPEDDLRRGRLIRSIIDDPANMPKDRKPIDPASIANKNAGPTGCVLMVDANQVWDVPQAVEYMKKLEPLKPWFIEEPTAPDDAVGHASIRKALKPLNIGVATGEHAHNRMVFKQLLQLDAIDVCQIDSCRLGGVNEILSVLLMSAKFGVPVCPHAGGVGLCEYVIHLSLIDYICVSGDMERNVLEFVDHLHEHFLYPVSINSEGRYNVPTDNNGGYSIEMFEKSMEDYAFPGGAYWAAVARGETPAVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTH0</accession>
    <name>A0ABR3BTH0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_102422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614436.1">
        <property type="nucleotide sequence ID" value="XM_066756967.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989279"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0250249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26998" checksum="209E42A7E8DF773C" modified="2025-10-08" version="1">MSIGTQSQRPHVVRTTASAPQTPYLGRLFFHVGTAAVMASGFQAMQNATTFGEFVEPQYGGFYQFLTILGLICSGIAMLFSGASDLLPNITLIRLIKRVFLLISLPVELVISSIYWSIILTAPELMLPPTSPDAVQGAPSSSDAGLSLFRIPLWIDLSMHLVPAVALLIDFFLLEKKYPKPFSTYVALFLAAAFGTSYGIWVEHCASINGAFPYPFLTIMELKGRVLTYIGATLGAWGVFRGLNGLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTI2</accession>
    <name>A0ABR3BTI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614447.1">
        <property type="nucleotide sequence ID" value="XM_066756978.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989290"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0250260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="547" mass="60292" checksum="EC6A214C13DF1CAB" modified="2025-10-08" version="1">MTNFVLPPIHDNADGSWGPSTSTLPAQFKDIPYAPFSKSDKITRIADWHDPQAEAAAGTRTSRTTQAGGRRTAYGAAEGTVFGFVHDKDEKSFSLVDSGVRVGARGKAPIRGRSVRGVASARGVRGRGGQRGGFSTRGGRGGARGGYGDWNKPQRTRDSSVTIGPEWEVLEEIDFNRLSKLSLTVEDPEDLASYGTVQAYDKAFDRINTRNEKPLEIVNRVRYNPSTSDDPIISQYAEKKEAQIFATDSVLAVLMCAGRSVNSWDIILEHRNGQVFFDKRESGPLDYITVNENAADPPVDSDDASNINSAGSLSLEATYISHNFSSQVSANSKSKAYTPNPNPFYSPEVESEPPASTLYKYRKFDLAIDEEEQFDVVVRTEADAYLGKKEVLVTVKALNEYDPRVQGGSGKPLDWRKNLDTQKGAILASEMKNNSAKFARWAIQSILAGAEQMKMGYISRANPRDAQRHTIVGVQSFKPVDFARQMNVSLSNGWGIVRTIADLVLKQPEGKFVLVKDPNNPLVRLYKVPDDTFDADAEEEEEEQDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BTT2</accession>
    <name>A0ABR3BTT2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614547.1">
        <property type="nucleotide sequence ID" value="XM_066757078.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989390"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33827" checksum="E031066FE6FD25D3" modified="2025-10-08" version="1">MLSPYSDPFILAQEYVAFLGSVYPTPVNEDSPAILSMPPTPDISNATLTSCYWNTDRPLSSFCGSPSPYILPNSVAMSLSIEPQHLILDSPPHTCTTESWELGPDKEFRKAYGHIEGSLWSNNPIDSDALELEPLDHSHYEPMTPEKGPAAAPAWMQDDEDEFEIVLGEFPVPPAVKACGGKSKPWKRLPMTNDDIRKQNKWLEKKRKLKYRQEEKSQVEKAEGRTKEKVKTSESNNQKVVVFERSVHTGASRDEIRIVRLQWKPRPHPSSVRFKAEEERKRAHAVGQQEQDNSGLSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BU55</accession>
    <name>A0ABR3BU55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614663.1">
        <property type="nucleotide sequence ID" value="XM_066757194.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989510"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRA" evidence="2">
        <location>
            <begin position="242"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="380" mass="41474" checksum="E2212B12277DC4EA" modified="2025-10-08" version="1">MYPHRTHLPSLHQVVLDYVITNAYASTAKSLSQIHAPGGEVLPSDETAMSSDLKAAANSNANGDQTTNGEADGMDVDVEMDGEGDNANSGENSDKSLDQGLALDEQALNMIERRREILEYILNGSIDMAVDLLNRHFPLVLSCAEPMISNYSTAANGTTSNGTVTPKPRLSPSGGSLQSESSINHSIPVLNSSAHPDHIRLNLQIQRFIESFRQMNPYSPSSPSSSTSSPANSQIFNGGSGVTLTHALSAAHGLHSEAKKLPADVRAIYLQEIKDVGALFAYENAEMSPLKGFLEQGRRIKLAEQVNKAILRSEGRAPQSQLEEYAKRLEVYYKVLEGNDIDPTPPWTAKDGLAKEHLASYWKYHELKNFNLHDFASLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUH5</accession>
    <name>A0ABR3BUH5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614515.1">
        <property type="nucleotide sequence ID" value="XM_066757046.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989358"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="862" mass="92679" checksum="6D7621C458920031" modified="2025-10-08" version="1">MADFDYGFARLQTSPATAPNDNASQSVSASDANDEGRLQATSDGNDDAKRDNGEKKGGPSADLGLAEGINSAHGGAQPPADPRYPYANLLASDPIQPSDQFRPDVATGYHPYYLAPDHAASSKPHESSSQPLPSLQNSQTPHRTQISRQQHRLHPYQTSQSNIMNRHTTARAQWDDVSSPDQEVQGQIASANSSAANTPASVPPPPAAAAAAGASEATEGTISKPTGRSGQKRRKKYTRTRTGCLCCRSRRIKCDEARPVCKRCTIAKRECVYPDGAGGSNPASGTDAPGVVNKGIGRSSGEDSESENDRDRKGRPGSPSALRYPPIPNGDLRYGGGSNVYDASALNMAPMPGGLVGNGMGGGMSLMEMGMAQQQQQQQHQQQHQQQQLSAQGRGGFGSEAGKQEWGLEQGGAPMLSTPNFLLPWFPTAEERSLILHYCANAASLLMAIPSGLNPMLAINLPLALDSPRGMNPSADALRVALLGIGAIHQAFLLARSGVSNHQTAAMFQYASTLRDTGKEMVRRAAHMGSTGTTDAALGAATALATIDMFFGGSNWQDNFSLAKEMVRARGGPAEMLKASTPKTLTEGVTVSPARLMLEILAIYETFGCLTTGQEPTLISERGENWWLEASRSTYEEHSVEKQFGMSRVMVLLFVRLTRLINRVAKSNIKITELASSTSSASDPYPQFASLIPTPSSTSGLNGATSFAEDSLIKEARQLNKDVDTWIESLQLSTLEHERVQVGNRAYAYAMKILLLRRVFKYTRDDPRVQSAAQQVLQHCSWSTAALGMSIDLTWPAIIAASCADGSSRQWVMTLLEGFKSQCCFDIDTAARIITEVWRRVDTGEGRADWKEVCDDLGLQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUI2</accession>
    <name>A0ABR3BUI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614548.1">
        <property type="nucleotide sequence ID" value="XM_066757079.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989391"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="275"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="346" mass="37427" checksum="63DEF8C83023AD97" modified="2025-10-08" version="1">MGDPLSEYNLYYHIPVIDHNRNQGTQFRPPIVPNHPHRALYAPPPSYIPIRPTTGLVYPPLPSPGQGFVNPGEIFLPRNTDVSQAGTPSNESVVSDRRPAQLLDSNNHEFSTSGGHDGYGLPPTQFNVPIDPFLFGEPQPGPAALFPQANEPWSFPADPVPGEPLADFQAHALPPSSVIDAEALGDMIVVGEVDKVENEEEEGGGNGNELSEYLDQRSKEKGKGKARQKTPKETVEKRKRGRPRKDASILAKGENPVGQKKKGKGKGTSGKGGWIRRPKACAACNNRHIRCIGGPPCNYCISRNKTCILEGGSLERKQTPPLTTSHPFEGPSASSSSYVPLAQSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUW0</accession>
    <name>A0ABR3BUW0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614912.1">
        <property type="nucleotide sequence ID" value="XM_066757443.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989797"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0250725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="343" mass="36556" checksum="61829FB7019C3CCB" modified="2025-10-08" version="1">MSSSSSSSDSSSGYSSSDFLSFKRSSIDISNLDTFLSSSITFPYMQQTYPPTDPSVVSAVSSVLRGGSFDISVPSDVSTALSERSSAAEREVREIGSGRGREGETGEEGVKKWMREREKRLGDMVESWVNNSATSSPFSSNPSGTFSSMRKLSTASIPSSSTMSTSTSGHVSSSQPTIIPSSSSSSDSQPSCTPSSITATGTLPARELSSASRRRLATTTAANLKPPPPKIDPSTTRTILSYIQSADSSSSSNSNSHPASRPLLNEEHWWTTYHALRSPSAFGAHGVPISLSETLGSMRALGWSDVVSDVRYEREKARMFLGDERFAGSHPQGNGIANWQQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BUX8</accession>
    <name>A0ABR3BUX8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6 alpha-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_102977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614948.1">
        <property type="nucleotide sequence ID" value="XM_066757479.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989833"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="114"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0250761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="191" mass="21204" checksum="538F52F16F9142EC" modified="2025-10-08" version="1">MKDISSIESLVVPEGVTVAIKARTVTVEGPRGKLTKNVGHIQMDIQLVKTAKNSKVVFTVWHGARKHVACLRTVKSMVENMITGVTKGFLYKMRLVYAHFPINALPSDDGSALQIRNFLGEKFVRDCPMLEGVKVSLSDVKDEIIIQGNDIEKVSQSAASITDKCRVKDKDIRKFLDGVYVSERTVVVKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BV92</accession>
    <name>A0ABR3BV92_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615038.1">
        <property type="nucleotide sequence ID" value="XM_066756261.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988565"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0252318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="314" mass="34014" checksum="E7094F90141A1F7A" modified="2025-10-08" version="1">MTVIPQQNADVVALRRGTGILQAEYSSSSSASSSSTSSAASSGGTVVAPYDTTGGGSTTVYLIALLITIIVLAGISAALVFRAYYVRRRLRRAMQESIRTGQPLPRDAAAALGIFPANRFGGGRRRKEERKVGVMPSMWEGAMYRDIEGGWEKDEEEDSLIEKSGKDGTWSGSGWDDIDPLTVVHLIPPSPPLPPEPLIIPQSEMPSFFRSLFTTSRPRRIPQNTTYHSARSNRGRGVNGTEGEGPVGTEEIPKTEPKWTIPPPGEEMILGVMIAMPTQGKGEELWETEGMEEGEEKDLPNVELGLINAKMGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BVD5</accession>
    <name>A0ABR3BVD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_102829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000004">
        <property type="protein sequence ID" value="KAL0250646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066614833.1">
        <property type="nucleotide sequence ID" value="XM_066757364.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989685"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17080">
        <property type="entry name" value="Ubl_SLD2_Esc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="173"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="351"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0250646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="425" mass="47415" checksum="147B0A38B205F6FE" modified="2025-10-08" version="1">MPDSDSDSSTDFFISKRKPNLKASTPPPIHSPSPAPSDSDEDPESSGRKKKKRLNSRKPQSKLPEWARQTSEQKKERKRSSVARASTETRDREGSNSSFTTAAAEDGAGKKKERRRVELTPPPVISEKKNQELRELVQRMYGGGSALDLLDDDDDVEPQPVSPIVSPQKEEVVDIVVKMELDPVKKARAPSVAIRMYERPTTLKLRREETMFRALEVMGDKLQRSPEDIVLIYEGKRVYSRDTARQLGILGGSSVEMKGYEKSYWDRLEAERLRRIENFDLDYSNRSPSPQPILQAQAPAQVSTAFKSKAQSQSQPHGASQLYAGLAPLVVEPPNPSHVNNSPPAVADDSIKLVVRGADGKEARMKVAKTVTAHTVLRFYCKKTDRPKDDANKMELVFDGETMGKDATVGDMDCEDGDMLEVRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BW10</accession>
    <name>A0ABR3BW10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_101960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615288.1">
        <property type="nucleotide sequence ID" value="XM_066756511.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988818"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="170"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0252568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28832" checksum="763CE35F5A3DDE51" modified="2025-10-08" version="1">MAQQLVHRLSPLIEELLQASDLSTVSAKAIRKELIARGADKYEIKNFRAEIDDKITEIYNSLESKEALANKLENPVSSSAKAPSSPSYSPFEPKTVTRKRKIAVSETEETDEQMARRLQGEYDGSRTRQQRSSRSARPAKKARRKSQAQVDSEERNDDKNEDKKKKRGGAFNKELLLSGALADLVGTHSLSRPQVVKHIWAYVKERNLQDSNDKRYILCDDKLREIFHTDRLHMFTMNKILVNHLRDPDDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BWS5</accession>
    <name>A0ABR3BWS5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_102235</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066756786.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989093"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
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        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="103"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="635"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
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        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
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        <location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL0252843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="717" mass="79905" checksum="08B3CC9BF54BDD6F" modified="2025-10-08" version="1">MPGISYDDSGSLASYFGVTCLTLILIPWTLSTLRPKKTKAAKPLCPCSICQQAPARVEKLQQSSRRSAGTKRIFLLLSAWALLGYLVYSLVTAPKVQGGTVYNPFEILGLSSSATEKQIKKHYKKLSLQFHPDKLKLAEGQTMEEAEEKYIELTKAYKSLTDETTRENLAKYGNPDGPQQREDRIAIPQWIVEGSNGLWVLALYGLVLGGGIPWVVGRWWFTQRRLTRDNILNATAERFFHSLAEDTDFTNLIALLAGSLEVAAVVGGNKVSKKVKKAKQSKIEELEAKINEAKEQNGIEEDPLMKVTSRVGVTSGADRRARALVWAHLLRIDLEDSEMRNDQLAVLRVLPPLLNAITNIALAHNWLSVSLRCIQLQPALVQAMPPSVSPLAQLPGFSFEEGFEQQITKKAEGDKWLEKWVRVREGSDKAFEVAKYWPRLEVIDAEFKVDDSKIVTPGSIVSLIAKVRYVYPTTALSSRAKPVPMLPKSEPAKLEKEKEDNEEAKLVEEVKEAVKEVNEKDEKPTVKEMQEKIVEKKEAKEVVNGFAHAPRWPQLRKPHYYFLLGDTKLNKVIVPPIKITDIPLPSPDGTPSEPKEINLQFQAPPQVNLYSFVAHLRSDTYLGEDVQVPIMLKVEEPPSETESDAGDDISEPDEDTLAGQMAMMRGENVKPSKVHGGEYDSEEDSDDVDDASDAESSSDDEGPTRARAYNEDSSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BXC7</accession>
    <name>A0ABR3BXC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_102161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
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    <dbReference type="GeneID" id="91989019"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="29"/>
            <end position="80"/>
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    </feature>
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        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="109" mass="12192" checksum="AE140F77C04E8625" modified="2025-10-08" version="1">MCETRKNGEQPSLTRPGLSLVAFDNYRAAKERRRKKQRTSTLSLTTVTHHTPRLALSHPHSLDPSPPSINLSTGHSQCEYKTGHSLSTTQLLQVKYHRIIHSRNPGGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYE4</accession>
    <name>A0ABR3BYE4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615266.1">
        <property type="nucleotide sequence ID" value="XM_066756489.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988796"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0252546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="155" mass="17338" checksum="A30A5CE217E71CF5" modified="2025-10-08" version="1">MDSNQLPSAFGKRAQYRPTKPIGNPLSPPSSNKGNTDRPRLEKLEYAPSNTRQGRKRTQSATSMHGIEGSFQKHRGNKPLSQPSTCKVGGADRSSGVIPRPSRFDRTPTRIFLNTFCEDPWASLTAQRMASERSQESRCDHEQLVTRCNSIGCRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BYY9</accession>
    <name>A0ABR3BYY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I308_100989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IND107</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="entry name" value="SNF5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZ01</accession>
    <name>A0ABR3BZ01_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="EEIG1/2-like"/>
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        <property type="entry name" value="NT-C2"/>
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        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
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            <end position="559"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAL0253617.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="840" mass="91750" checksum="7DA0DEE893A405F5" modified="2025-10-08" version="1">MTTATQRQSMHDDPATRSGSSTALPSTFSMTPTAQTSSTVTLPRQNEHSRPITRKLKHMFESQKYAIFNAVVVLHEVNNVPQLHGGFAAEWRFRGKRPKGRDSLESQGKSHTGPKIKPSLPNLKMGNPSASSISVRTSSTSSSIPVPLTPRSLISHDSRRLRPPDKAFSLPPAFLGENPTRPEKKRSDPTPLKQFITSSPKGEKLPPVESPRLMEEPQEFFDDISSPDGGMDDSNSRDSKSSKVSKKGSWGSKSSNSQENGGPQINIRKPTFTSPSTPFLPNQESRQHHYSVPFPRAIGTNLRLPAPVRSGTLPSYATLLDPADPVDLQRPLMPHRSASIASVSSSSSDTTDWPLGEQKRPATPRLRSSSGPGPSTTTFKDVDSISTHRKGETPIQPLRSHCCKWDFELRHTLRFPLSKPSPSASSAPKGGQPTLILGNGPMSDSGLELTIFQYPAKPQAQQICSTPSPSLSDGSSPSIAQSAIQSVASGLNAVAGSKPMKKDVKQTRKERRFEKSPIKFGTIDIDLAPFAGKGRMTRRFLLKGSRTNATVKVTVELQWVGGEMNWVAPPMQEGHHVTGVGDLMAENHESIRGDLYLIKTPSSSSSGSSNALERTRTNMTAITSSSWRGGHSVQSLGLTRTRTSGTHYEPYEHHLQNESPIYTPPRETGSPRRCLSPPPDGRSKPNTPPPHPPDSSSASSHLDVPQTSSPKPFPMIPSLQDFPHRVHRHHTHHLPRGRPAKHSDLHDLPPETIIEAIFNPHPSTQAGPFTYVPDEYSDAEGGDSIMEGMVMDANDDVEEPQPEKPAKKEGRRLGWIRGRGRQEKTGRTKGNALSQRAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZG2</accession>
    <name>A0ABR3BZG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_100904</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615752.1">
        <property type="nucleotide sequence ID" value="XM_066755466.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987762"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="18"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="313"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="625"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0253531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="800" mass="88801" checksum="40F4CB5B66AD1056" modified="2025-10-08" version="1">MKRKPLRAMYSTVGLKWWIAIIMKSCAAALQLTYPLITQQLIDQLTKAHAYHNDPANNPPPKSVVYSFGLAFALFAMVQASSLFSYQALQRGSVIGFMMRAALIDLISSKSIKLSPTARVEMTSGKMMTMVSADVSFLDFSAPMTLDLVVQPVQIVVGLGLLIWTLGYSALVGRAVLALAGPLRSFMFAVMVRNRQSQLTYVDARVRLLSEVIASIRAVKIFAYVSFFSNKVTELRKKELVFLKKNGFYRASMNATMAFIPALAAVLTFITYRLTGHSLTPAIIFSGLQYFNVLKTPIAFLPMCFTAISDALVGIERIGALLRAEEMREGVNVQVDASWAVSVKGDSEFEKVSGSKKENGTAETKKEQAKIEKKSFRLENIDLRIPKGDLVSLSVELGRERSASYVPQQAWIHSGSVRDNITFSAKKEEIDSARLNAVLDACALRADVQAMPDGDLTNVGEKGLFLSGGQLQRLSLARAAYAQSSIVLPDDPFSAVDAHVAHHIFEKCIVSGPLAADWVVVMESDGHKVGRMAQMVRYDDLRSQQGPFSSLFNEVGSATRQSRAHTPTLTPTMTSFKPPTLPPKECREYERKTSQGPMEEDRQTGSIPWSIYATQQQWEITYCSVFVYAGLGVGIGLFTFGASYTMFLSGLRSSYSLFARAWEHVMRAPTKWHDQTPSGRIISRFSKDIGMLDDRMAFSWETLLDNGLSAIGTFGLILYSYPWLGLAFIPLTIFYYIARSYYRQTSREIKRINSITRSRIYSSFGEQLAGSAVIRAFGKQSAFERRMEEAINAEGVSKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZJ7</accession>
    <name>A0ABR3BZJ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616026.1">
        <property type="nucleotide sequence ID" value="XM_066755740.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988040"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="116" mass="12987" checksum="594E332336379E1D" modified="2025-10-08" version="1">MDCGLGHRNMQWANASVCQNWKHCCDRPASLGVTRCAHYKWKDSPCLECLVRAPLCRLEKMIEEVVYTPYIDRIAKNFFTKLSKPTAAQWTRGPGSTGDALALGRSRARAQTASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZK6</accession>
    <name>A0ABR3BZK6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616046.1">
        <property type="nucleotide sequence ID" value="XM_066755760.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988061"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0253825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="280" mass="30259" checksum="8253B24205D7FC42" modified="2025-10-08" version="1">MGGEESLPSSAENIGPKRRDPFHRRVKSYFTTEIDAPNSTNLISIYACFLTGFTSAPSFTACYVWCGFQTGNVAQLGVAIARCFAPGSERTFGFQKPDQQALTSLLSFWIGTSLGRFGDWSGARKRTWLGLATLLQAFLAMAAALTAHYSGEDGIASSRGEPSWASPTGMAALGFLSATMGIQGIVGKRIASPMNTTVVLTTTWVEIFNDPLLFAFKYTPSRDIRIAGGFSVLLGAFISRAILDASSSAGTCGVLAGLRMVQFIWWFFIPDKQVKRVEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZL9</accession>
    <name>A0ABR3BZL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulfite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_101205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616048.1">
        <property type="nucleotide sequence ID" value="XM_066755762.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988063"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0253827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="53643" checksum="79DF00AA35941CF2" modified="2025-10-08" version="1">MLCMLERLPQTVARALNGRMASPPDASEITVAESSGRDATLSLPRRVVRRIEYAILNISPAFFSFNMGTGITSILLYTFPFNAGWLRRLGVVVFISNVVLFILIAFASVVRVLRWKGIFLATLKNTSAGLFWGTLPMGFTTIVNMVALACVRVGTTGWSRTAIGFWWIDIILSVIINLGTVYIMITRQSHTTDAMSAAWLFPVITCVVASASGGVVSSAVMSYSPHLARSIVIVSYVVWGIGVPFALFIICHYLHHSILHGTPPVTALTSAFLPLGPCGQGSFGIMALGKAVRELAYNHGIGFGVVPDGVADAVLRREIILRMADAVYTGSLVTGLILWGLAFCWYILATTVLLDHWWNTNRDYFGKESFSIGFTALIFPIGVWTTATTTLAIELDSLAFKILGTILSVQVILNWIYVMFFTIYKVCDGTIYIAPELDIFPERNPPLRWLWPASATAKIYRKEDIELSPNLTDERRAGLVNSHREND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZN9</accession>
    <name>A0ABR3BZN9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar transporter chaperone 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616013.1">
        <property type="nucleotide sequence ID" value="XM_066755727.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988027"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0253792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="123" mass="13613" checksum="615157EC4613834F" modified="2025-10-08" version="1">MSTQPLLQRTAKKRIALPVRVEPKVFFANERTFLSWLHFAVVLGGLAVGLLNFGDKVGKISAAMYTIIAMGVMLYALVIYQMRARAIRLRTGAPYDDRLGPTILCVALLAAIVTNFILKAVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BZR7</accession>
    <name>A0ABR3BZR7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-aminobutyrate transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_102151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000003">
        <property type="protein sequence ID" value="KAL0252759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066615479.1">
        <property type="nucleotide sequence ID" value="XM_066756702.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91989009"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0252759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="479" mass="51841" checksum="A6CCC1EAF48185F0" modified="2025-10-08" version="1">MSPRIATLLSRTIRTSTRSFASTSVNMSAPVRTSAQWSDFGREHVSHGLGRIKDHVIVKGEGLNLHTADGKKLLDFTAGIGVTNLGHCHPAVSKAAAEQINNLVHLQCSIAFHQPYLELIEKLLPVMPHSSLDQFFFWNSGSEAVEAAVKLTRKATGKQNVIVFQGAYHGRTMGSGSMTRSKPIYTQSTGPLMPGVIATPYPYWHSLGVSPSTSEEELVNIAKYQLDLLLRQQTSPKDVAAIFIEPVQGEGGYVPCPPAFLKHLREVCDKHGILLVVDEVQTGFFRTGKYFAVSSIPDFRPDVLVFAKGIANGFPLSGIASTKKLMDTLDVGSLGGTYAGNAVACAAGIAAQEIYASGEIEKNVAARSEQLFTALNKLASSEKTKHLIADVRGAGLMTAIEFRSASDPLTHEGLPEGAKIPKDIGKRVQAYCLEKDLLVLTTSCFDTIRFIPALVINEEEMKRAMDIFTEAVEKVALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C083</accession>
    <name>A0ABR3C083_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_101409</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616251.1">
        <property type="nucleotide sequence ID" value="XM_066755965.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988267"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0254030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="142" mass="15770" checksum="01D8A19991E968E1" modified="2025-10-08" version="1">MLASVSRTLLRARPVVAAPLRPVAFTAVRFASGGAHGNETETYESFNARYETFFKSVSDLFELQRGLNNAFAYDMVPSTEVINAALQAARKVNDYATAVRILEGVKEKVENKGQYQAYLEELKPTIEELGISTKEELYGQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0A3</accession>
    <name>A0ABR3C0A3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoadenosine phosphosulfate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_101446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IND107</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616288.1">
        <property type="nucleotide sequence ID" value="XM_066756002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988304"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="5">
        <location>
            <begin position="43"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0254067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="272" mass="30072" checksum="65D2C747AB2EE88F" modified="2025-10-08" version="1">MSSEDILTPQYTPEEIERFNAELDGKTPQEILTWAVDSVDGLYQTTAFGLTGTAAVDMISKISLSREETHLVPLIFLDTLHHFPETLALAQTMADTYLAPLHIYTPPGVSTAEEFAAKYGENLWETDEGAYDYLVKVEPAARAYKELGVRAVITGRRRSQGADRANLKVLEIDERGLLKINPLIGWSFKEVKEYIDKEGVPYNPLLDKGYRSIGDVHSTAPPDPNAASDAAERSGRWQGKAKTECGLHTNYFEMKKKFEEKAAAAGGASKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0A7</accession>
    <name>A0ABR3C0A7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_101396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616238.1">
        <property type="nucleotide sequence ID" value="XM_066755952.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988254"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0254017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="95" mass="11114" checksum="558CBCD9CEA10E35" modified="2025-10-08" version="1">MPVMYKVLRLHVECRNKFDLLESSSNRFIRSLEKKSRIRQESCRLEANGKLLHAHFIGLSEILYLLRLVTPVTDICLVRREPGEPAYKFTKKAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0C5</accession>
    <name>A0ABR3C0C5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein arginine N-methyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_101411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616253.1">
        <property type="nucleotide sequence ID" value="XM_066755967.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988269"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="63"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="6">
        <location>
            <begin position="166"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0254032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38637" checksum="4B307FDDF97FED58" modified="2025-10-08" version="1">MSPATETATQGLPPVDQMTSRDYYADSYAHFGIHEEMLKDSVRTLSYRNAIMQNPHLFKDKVVLDVGCGTGILSMFASKAGAKLVIGIDMSNILDQAEKIVRANGFSEDQIVLLKGKLEDVELPVKQVDIIISEWMGYFLLYESMLDTVLLARDKYLAPNGLLFPDKATIFLAAIEDQDYKEEKIDFWNDVYGFDYSCIKEIALREPLVDCVELRAVATNPCAIKHIDIRTVKKEDLAFDVPFKLTATRNDYIHAFLGWFDISFSCCHKPVNFSTGPQAKYTHWKQTVFYTSETLTVSEGDVIQGTLHCAPNSRNNRDLDIVIDYEVTGSTPEKGKMEYKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0I4</accession>
    <name>A0ABR3C0I4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_101506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616347.1">
        <property type="nucleotide sequence ID" value="XM_066756061.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988364"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0254126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="356" mass="40841" checksum="B5F4430E873B24FF" modified="2025-10-08" version="1">MSLWVDKYRPRTLDDLHYHDGLSSRLKSLAASGDFPHILFYGPSGAGKKTRIMCTLRELYGPGVEKLRIDQRVFVTPSNRKLDVNVVQSNYHIELTPSDVGMYDRVVIQDILKEIAQTQQVDLNAKQRFKVVIINEADALTRDAQAALRRTMEKYMTNMRLILCANSTSKIIAPIRSRCLLMRVAAPTDDEMTTVLNYVAKKERFTLPSPANNAILETSQGNLRKALLVFEAMRMQRPDLSGDIEVAKPDWETYCGKVADAILQEQTAQRLLEIRAKIYELLSHCIPPTVVMKTISERLVEKVDDTLKPQIVHWTAYYELRMRMGSKKIFHIEAFIVKVMTVYKQYTLMGFTEDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C0W9</accession>
    <name>A0ABR3C0W9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_101608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0254227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616448.1">
        <property type="nucleotide sequence ID" value="XM_066756162.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988466"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0254227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="156" mass="16971" checksum="CF9475AF10371A2A" modified="2025-10-08" version="1">MFIRTLRLAPTLLKTPFTRTLITTSRMSASYQVVATDKAPAAIGPYVQAVTHNGLIYSSGSIPLDPQSMEVVPGGIEAQTNQVFKNISGLLTASGITPAQILKTTCFLKDMNDFVAFNKIYAEFFGETKPARSCVEVARLPKDVLVEIEFIAVAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C2I6</accession>
    <name>A0ABR3C2I6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_101350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000002">
        <property type="protein sequence ID" value="KAL0253971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616192.1">
        <property type="nucleotide sequence ID" value="XM_066755906.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91988208"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0253971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="207" mass="22946" checksum="F59F113645233451" modified="2025-10-08" version="1">MELNGGSVVAMIGKDCVAIASDLRLGNQQVGIAANFDKVFPINDKLYCGLPGLATDVYTLREHLRFRVNMYRMKEEREITPKTFTHLLSSTLYEKRFGPFFLEPVVAGLTTPTPLEPHPKPYISTMDTIGCITTPKDFAVAGTAADKLYGIAEGLWEPDLEPEDLFETISQTLLNAVDRDALSGWGAVVNIITHDQVITRTLRARMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4A2</accession>
    <name>A0ABR3C4A2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Abscisic acid G-protein coupled receptor-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100262</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616735.1">
        <property type="nucleotide sequence ID" value="XM_066754834.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987120"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="8">
        <location>
            <begin position="348"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="7">
        <location>
            <begin position="472"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0255458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="76284" checksum="14DCE47BD3407302" modified="2025-10-08" version="1">MESSDPPPVFASTFSSSPASSPILFDTFLLLLLRLVYFFISRKFLHSTINPTLRGISQPETILPSTVSIPTADSSRRAGVSSVNETEYYEETDDTGFTPVSSYPGSPAPISLALASSSNGSRREDNPGYSSSSLPSYPSQGENTIELQAVGQKLKDASSGVSRKVLQLSHGKRSGAGTKRVKKATRGLHRASRILFSVCFAEGCNLISLVIFHAIGVLNARSRQVNFSVSLHFILALILVVVPLVQCLLFTYRSRDSSSTSTTPSQSSSLSFTSRLLISLIPFTLYMFLFTRIPPYITAVPVNFQVVPTPSVDMDDPSSTASTIDEAIVQWSTSGPEGWEQGGWLAPSLGRVVVLGVVILGSLSGFGAVRSAWNFFEHRRAGSHTLTDNDLLQAERSLYRVRQDLISKKNEINRYVVPSGESSSGWMGRIFGGENNQTAALEAELRGLETMEMQVSRSLKAMKARKRRQDFGHTFRGQIYNILGYVFAVYCAARLVMCLPSLFFAPHTAEQESGEIPIEGKGNTNGDWISFFLALAISKLPRDFADIDVPTWSRGISLILTGVLILSSLTQVMRSLSKILRLTSKTVGAGFLLLSLGQLFATYVISLLIQLRTSLPPTLPESDPFSNHGNYTGMDYDDQSSIDLSQRDDSLLSTLPDFRVFGRLFDIMFLLAAATTALYRYIVLKVASADDIGDIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4E2</accession>
    <name>A0ABR3C4E2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616784.1">
        <property type="nucleotide sequence ID" value="XM_066754883.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987169"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF18">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1310"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1530"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1530"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1547"/>
            <end position="1558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1558" mass="169143" checksum="773621E14DCFE381" modified="2025-10-08" version="1">MKGHQWPQRDKYQYDHHQDHQRDLPPPSEVADSYTGTSPPLPTLPPISQILRSPPPTKKLGPTWTVRSPPPSPSSLALSSAGPYPPAQTLPPLTSFHRSPSPLLSPPTTSLASPNPVYSSPNRPKWAIRPPSPQPLPSSLDAMLQRGAGPHSQVSATRRFSASHPGAHRSFSRTNGSPYSASSNKVQILGRSEHSPLQPLHLPGTEVDREELLPKANANDGTSLSISSVQPPEPSLHMPPLDEPLEVPRPPTPPLPPPSPAHPPSDRPPTPPLPPNLASPLPTASPHPPTPPLGPPPEVIPPANHLHPPNRPVDNTKATGLNGDTLTHAFSLENYDAGRYVSATRTQPQPHHPLNPRKRKSSISTSSRSHTSEINSLGSKSAATLRHGKQKAKRSRIRQSLPPHDHSISERVPFPLPPRPSRYPENAAPNGPDGPIAPSTSSAGRDSVASRHGAEKNKNKKGRPSSLPPGSVEGRSMGSISDRSPVTQTVTTLPNGGSALPPVIPVHPPVPVSRPVPVDPRIPSKPHIPVDPRIPCDPRFPVDPRMAGGSRVFTDSRALVKPHPLYIPRAPVDPAVPLDPRTPVDPRTGRPGSRPVSRQTTPAPIINGKPEANHLAQGPTSMHKSENKGTVVVPPRNYHDKQSAQQTTLPHPGVSYVPANIQSTSALESLQKKPLSQSEAFLAAKAEIEARKFSGNAHTHITSSNVNVSGAADGLPRSAGSISVTGQKVHPDALADDDNEPKHFRLPKHLLALFKVKKGLTDNVTDSTTSPDVNPPKAAMSATVEPATVEPAVVEPTAVEPTAIEPTAVEPTAVEPATVDAVAVVPTPKMQPIDNAPVAEPLRPSDPETSQVPLRVDESRELHKAQLPLLAGAKPDARPSAARKKPSASANGGRSPARPPKKRKEGPVTTRKRKQAPIPPEPSHAPPARKSEPQARRKIKQVINISSGLFPPAIIEEIGGLPIESSFTFKGVDFGRRGEGPDDCKIHDHTSPVDPENLFAGSRDLSPSVSSQATQPSQPSLERVREPLFLSRSPTPYSESPPQKISFQNGTAVQVKEEAEIAFDRPDPAVSADPEAEPSSIGMRSAQVDENGVVTVNDQWPDDSRAVVGLSGADEADELLKRYQLIVDRESTPTSLDIVLSRSSTEDELTDVCSSPEIPLASLRFKNLQAWSWRNKSHGTLDRLSVVLPISKARRRKLIQRGIYDPFEDDASEEEVGCPARPENAHRQPPMTAAPHEMTDRQRYAQTATSRSSLRTLYVVIPPEGSPYNVRVRSPSPLGPRLRPDVPSVPEMYQDVLNETLLDRCTARECRWDDCDAILGSENTLGMHVHRHLANEKGAEGRWKMQLGVSSWIFTGLDSGRMKTEAVPNEYLYKCLWRKCDEPCFTTKEKLLQHMLLKHVSDKLICPYGWCRYACPSANTLARHITKIHAKTSDQPRPMLLPSSLRRLPPPTPPPLPMFVPSYLLQCTALPRPCRSVRELKRIREEITDFCATPDDPVMAAWEEDDDDVKMKHMLDASSPVKDPMAYIDHYEHVPGDDTSDSEQKDGGSSSFEESGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4E9</accession>
    <name>A0ABR3C4E9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-type H+-transporting ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I308_100304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616777.1">
        <property type="nucleotide sequence ID" value="XM_066754876.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987162"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAL0255500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="12835" checksum="7140BF06FB0E6174" modified="2025-10-08" version="1">MTSILRLSAQKAPMAFARSFSVSAVKMDLVQDLYINQLKSYKPAAKAADAHVGSVRSFAAPKAPSAPSLPTDLASELSKFDATEPTIGGSAPKTVASSEGGESVEQYLAFLEKDLPKADAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4M9</accession>
    <name>A0ABR3C4M9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I308_100388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616860.1">
        <property type="nucleotide sequence ID" value="XM_066754959.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987246"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAL0255583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="359" mass="39557" checksum="91B861E0412680E7" modified="2025-10-08" version="1">MNRQVLNNGVYTLSDLEEESKKTLPQMVHEFYNGGAMDMITCRENVEAFNQYRIRPRILVDVGNIDMSVEIFGQKVAAPLGFSPTAFQRLAHPDGEIATSMAASKAGIPMCLSTYSTTSIEDVVTAGQGAIPYVMQLSVMKSREANLEIIRRAENCAVLGRRLNEARNNFTLPDHIELPHMPADCDWRNLVVEDDRLKYDASCTWKTLVDWARSHTKMQIWLKGVYTAEDVILAIEYGIDGVVVSNHGGRQLDSVTATLDALPEVVEAAAGRIPVHIDSGIRRGTDIFKALALGADHVWLGRAVIWGLAHDGEAGVSLAINLLLDELRTTMTLAGCANIKQITKAHLARRGLDGRLHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C4P2</accession>
    <name>A0ABR3C4P2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_100402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616874.1">
        <property type="nucleotide sequence ID" value="XM_066754973.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987260"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="105"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0255597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="347" mass="38756" checksum="AFCCD16581BEBEE2" modified="2025-10-08" version="1">MLSSNTALTIAKRSLIYPSGFPEGSRSVVPKPIEVGCPYEDVTLTCSDGIKIKAYVIMARKKPLMLSELRGLSPTERKERAQYEMEAWAQEMGDEKAIEYSKSRPTVVIFHANAGNMGHRVPLARHFNVDYKCNVFMLSYRGYGLSEGKPSEFGLQIDIQTAMKYVQAHPILGQTKIVLYGQSLGGAACFYAASKHRDTVAGVIVENTMLSLKTLVPLVMPQIPKFLLPILLTEHWDAHKTVPLIPSTTPILFLVGKRDTLVKAEQMVALRELRGSGRTRWREFDGEHNDTCLQPGYWEEIGKWLREEIEDDGIEDDGIEDDGIEVVDQNDGGKENSVKVTEEDAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5D5</accession>
    <name>A0ABR3C5D5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I308_100641</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IND107</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617109.1">
        <property type="nucleotide sequence ID" value="XM_066755208.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987499"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="34"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="471"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="525"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="610"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAL0255832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="700" mass="76161" checksum="E1C240A17EBC256D" modified="2025-10-08" version="1">MSTIPPDTEILNPTDEEFYASWGLCILCLLLIGALISSYYLQVKRIRAVHETVVSIFAGMVVGLIIRLSPGHMIREMMSFKHTFFFNALLPPIILNSGYELKQENFFRNFAVILTFAFLGTFITAVGIGVLVYIWSFLGLEGLKFTLLECLIFGSTLSATDPVTILAIFNTAKVDPKLYSIIFGESILNDAVSIVMYETLSHFHGEDIYLSSIFHGVGIFLFSFLVSMALGVSFGLACSLGLKHSHLASYPHIESCLITLVAYTSYFFSNGIGMSGIVSLLFCGITLKHYAYHTMSRRTQRTTKYMFGVLAQLSENFIFIYLGLNLFTQDVQVFKPLFILVSAIAVMASRYAAVFPLSELINWVFHTRGQRAEEIPHSYQMMLFWAGLRGAVGVALAAGITGDNADALRTTILVVVVLTVIVFGGTTSRMLEVLGIRVGVEDEEASSEDEEPWTTHQGHLALQSGSISRRYPYSSQNGRGWENPSEFDLQSPEGSPYNQTLKLSQSRQARSSSYGQGVYGYGVRSGFSTNSDESDEEVLPSAGPSGSYGDGYDPEAGAPGSSSDSRAGEGRGTGMIFRDGQWFTALDERYLLPLFSNSVTARRHHAKKAVRKGAMAASGAGGGGTAGSGSKSGSTAGTPRRESLELGDDGYGGDGESENGKNKGLPRTFSGSVSDFFFSKTEPSSLPSASLSLDERENRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5J4</accession>
    <name>A0ABR3C5J4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Solute carrier family 25 (Mitochondrial dicarboxylate transporter), member 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I308_100707</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617173.1">
        <property type="nucleotide sequence ID" value="XM_066755272.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987565"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="100"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="196"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAL0255896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32346" checksum="59630CFDFBBBB7D9" modified="2025-10-08" version="1">MGPTQQKYPFWLGGAAASMAACCTHPLDVMRVRMQTSTTKTTFVHAVRTVLTHVGVRGLYTGLTASVFRQMTYSVTRLGVYDVMKNTMSNNGVKKLRTGDMVICASVAGALGGVAGNPADIILVRMVADPTKPVDHQVHYKNAIHGVYKMVSNEGIASLARGLAPNIIRAILMNASQLVSYDFFKDHILAANLMENGMPLHFVSSALSGTVATTICAPADVVKSRIMNMKAGAGGHGPVGLLLESLTHEGPRFLFKGWLPAWIRLTPNTICMFVFLEQLRNAVDLFRNSSARSQPAAQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C5V6</accession>
    <name>A0ABR3C5V6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I308_100819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IND107</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CSM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0256007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617284.1">
        <property type="nucleotide sequence ID" value="XM_066755383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987677"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="8">
        <location>
            <begin position="177"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAL0256007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="388" mass="41926" checksum="02FFB954149EE0B1" modified="2025-10-08" version="1">MAGLQDLFNSPPRPPPPRSIHSLSPSTPARATRPNQNPLFFSPGQSPGFEPAGRGTSGFDDSTRDVPAFGRSPSPPTGPQVIRVEEQREQDATNGIVRIRQAVNVLPDGDSALRGGGSGTFTAGTAETAGGGRAGGWNNGVFVNNSVIRDPLAGLGADDDEDGELGDGIEKKRVIAKVDADRLLSEKGIPALCRAAKKFKPRGKGHEADDLRRVLNMYQMWAHETVCRSRRMESALSGFRDAFKPRPPTPPREFSNPPRASRSRSRSPSRARSRSDSPSRARSTTPNSNSNSFRVPTYTTTAMTTAQRHVMEQLLKPADPRNELNDGLDMYDLMAMEEEMAMEAEMAMEAEAAAEVERAMADAEAGTRTGAGVGTRKGEEDEFEGLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C6B0</accession>
    <name>A0ABR3C6B0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_100681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066617148.1">
        <property type="nucleotide sequence ID" value="XM_066755247.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987539"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="235"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0255871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="418" mass="45591" checksum="921C28DFE495DBA9" modified="2025-10-08" version="1">MSSPPTVHPRRPKPKRLSLSLPLSPETAPSPARPRPPGPRRPSLLTLITQPPAAYPAPAPASPSSSSPTASTSTTPTTSPPLPPTFTVAVGTAYPFRQTEPYQHGPVQVLPGIWLGAEESVTRWDVWATSTTGNRVRVVNVAQEVEDPFDPGLSRVSGWPAPSGLPEEMPRRKLKLKAYPAGAVAVGDGARPIPHVEYCHARWSHGELGLADLPEGACLRDVLYPRAPENNERPWRFWETIRWMEEGRQRGIPILIHCQCGVSRSATLAIAYTMALAAAGAMPQYLGHIRVMQDAYDFVKGKSCWIGPNHSLVFQLVDFARSLTTLLSSHYATTPNALVKTSFPTAAESELSEAEWARRRREFDEDDMGEYTTDLSTTASDGQTAVESCMSAEEAGEEARRLDAAMLARREAAIKQGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3C887</accession>
    <name>A0ABR3C887_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_100491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000001">
        <property type="protein sequence ID" value="KAL0255684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066616961.1">
        <property type="nucleotide sequence ID" value="XM_066755060.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91987349"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0255684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="834" mass="89750" checksum="10289E42F1BF7C21" modified="2025-10-08" version="1">MSPPLSLSLPIAPLSASLSAHVTALKTLSLSLALLPAAGHHSARIPFTAKASLPATVTDTQHVLVCLGTAGAGGDHAQGEQYWVKMSPHEAADYVERRRERLLLQQARAMDGVSNFVAEEQEENVDQEQELWPFHPLFHNIPSAGPSQTEKLSTIAGLERVITSVTESPVPPVKQQPEQRPDPDPTVTGKAEPSSIAVIPSSSQGASSSTTDDLIEIMTEGAAASAREKGGAEKDETIFNEEGLPFHEIRETLNGETIGSLPPATADPTANIEVLANDEKDGYWSEDAIARRAALRRKIFHEGEESDGEEEFIEQVEQQPQVASPSLPSDPPAPNPEPTQLPSYPSSPKAELHPHSILRHHEPSSQPKSILKPPIRKKSVTFDPSIPPASPDSPDVAPSSVKPHKFGFPLPLALDDHQDWAPKPVPTITEPKPKAKKEDDFAGFKKGFLGPLPKVRTAAEVDQNPTIISEQVPPESSQETLKPKPKKKSLFAQRLAHPEIDSSAPATSSSTPATASPRSINLPRMAESKGTSAIKGAVVEKPTTTPVPNTSSSHTSGSVVERNIIQPVASSSSTSKQDPSSGISVTKQTSNDDGDDSNDEDSFAEYSSGSEDEYDLDDALLAREVALEYHRRHAYTSLNRDPRDAPFEEEDDNGGEGSVAGMGAGVMLGLPRISDLQGQDGRPVIVNPTPDDLKRFVRVGRLENGNLVLAPGQEGLSDSEGDDGEEEKEGVDDEAKERRERRLEVKKRREQVRNRLMGLPVEGGDIEPQKNRDSVDESLKAMLPPAIQTEVAERQVAVPTPSAQIDTSAAEAKETPVPKKKVSRFKAARQAGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BHH7</accession>
    <name>A0ABR3BHH7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I308_106725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IND107</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000015">
        <property type="protein sequence ID" value="KAL0240177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610685.1">
        <property type="nucleotide sequence ID" value="XM_066761145.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993578"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="1209"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="690"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="779"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="853"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1088"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1281"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1451"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1529"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1647"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1766"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1825"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="853"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1096"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1281"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1466"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1479"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1553"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1572"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1647"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1669"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1786"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1827"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1844"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1861"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1899"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1943"/>
            <end position="1964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAL0240177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1977" mass="217617" checksum="E0B20DACDC39CF02" modified="2025-10-08" version="1">MDDLAPLPTTFDPDNNDDFDADNSRDVGHGSGDGDEDDVDLLIVHGREEEEDQQQEEERNEREGEGEADGEDQTNLMEYIASLQQIGEHDNDANQDQDHDPETGHMLTQPYEHEAEVELGPEEEEPEQQMVVDAEEGKERELGESDRNQNSVPNPSSPIPTPRSTQLQSTQHGQGKEKESSQMGIDIGRDEQMDVEMEEELGESIEVDPGPESGELHEPEPEFERDASSPLSDLPDLPDELEFSPPPSPGPSGPSRSRQRRQNSNGNISIGTGLDREVDRDSSLTPLYDHDEGEDELRSRSHAQSSAAGARRSASISNVNANTNKRGGNKDSRDRENQGRTRGLLLSSSPPLESIEVAPDISPPLSPVQSSSSRMTMTGAAGAGGKKRQRGRPSKETLALRQHGNGPSDGEGDSEIELVPKPTKRSKSSHPFSSSHASSSHPASSHPSRKPLDPISTGLKLPGPRALPPSRPRALNDQSIKKILVGKTEEVQLGVCLRERYKKWGKCTQVFPIDPKTTEITGPGYFKSTTWPEPLTPLPTKFTSPLDGDKVEEIQRTVAGVLLPLITGEARHCFWPFHLQGQGRQEGEREGASDPTHHINPTNAITLHRGVDTALHRSVCDFCSSTIFGGYYFCKKCGRDYCLQCERYFPDSMEAVGESPWELTDAARPRLLKCIKQPWEEMMNGGGVEIGGNESIVSGNGNGSARTNTNTNTNGERNSGSTGKSGRRREKSIAWHVRGDLQPVSRFTKEEIERHWLSLAEFAIGHGFGPDAGSSSGLGFLFGAGAGDKGDEDEPEREKKEEERSLQREGMLRVMGLQMDEEVKRVLEQWRKEIRVVREKEKEKERSLVAHFETNTSIESNPKTNTNLHSVSNPESSSDAVDSQASIEKTSSSIPGSAVTTTKDENKQEQKVDEVEDLEMRELNNAGEMLKNIMETEDEGQKLAVLTDRTAPLNSVASAYEIVRSPTPITSVKSPVATNVSSTISSSNSLQVNTVEKFSAPVTFTLTSIPTSNASPKAAPDPKPNQQQNLEQISFSYTKYTHPNPPSDPANLSDCSLPFIYLPSPEGLDNKAFDELWSKGEPIVVGGVNVHVGGGHGERRRGEGEKMGREGEEWGPEKFIERFGEEQCSVVDCQTDTPLVSTVGAFFAAFGENVSRPRGMEGMGEKRKEKKRQGILKLKDWPPGDEFVNTHPELYHDFCAALPVPDYTRRDGVLNLYSHFPPGPTRPDIGPKMYAAFAALETPGGFGSTRLHMDVADAINIMLHASPIPDDSSTLEVTTSIDPLSTSPPSLPETISPTGSKIQPKPGCAVWDIYPAQDADKIREFLKEKFDKTHNFVDPIHSQMFYLDAKSRKELWERKKVVSWRVYQYPGQAVFIPAGCAHQVCNLSDCIKMALDFVSPHNVPRCQQLTKDFRRENYLKAWKEDVLQLYNILWYAWLSASETVARREKEAAASEARRGQLHPFRSNGSGSPPFQSKVPTSSSTPTATSPLDLDSSSRMGYDRLSMSMRIGERGMEMGLGRVGMGSWGNLSSVRDEPPRGGPMPLVLNGQSEKISRGEVAEDKGSGESISEMNRRKKEDHEGKSDQGEQLTSDSSLSVNSFSSFLPLKIAKSLFTLALQRDETNPSELFVPSAAAMNHRPRGTSLLESQSPIARPQSSSRPLSAHTVHGRSSQASASVRTKHTKEKENKNAPPKKLKNPARPLRTSTLIKLGAKRMDEILELARGDLGEGETSGNALGDLGNFAQLGAVESHGGMQGWAGLRAISESSKSREDGGREASPLVSINDVHNSNSSPNAEADTSMPFDDAIDRTDAETAADIAAEILSMDIDHQEHETNIEDDGDLEGLRRIVERGILEQGQDQGEEREQEDDERDNELGEEGREAIASIQRLQAVEEEERERDILVKEEEREREMGRPQIVAANGNGEKEEDEQTERERARQREEEEEEETEGEGEGEDAGGEGYEEISKMGVDFGMFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI45</accession>
    <name>A0ABR3BI45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610769.1">
        <property type="nucleotide sequence ID" value="XM_066760944.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993372"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="253" mass="26759" checksum="03D9E747136AB5AE" modified="2025-10-08" version="1">MSHVEGANEKGTGKTEVRLRNLKNVEGIKYGHFITSFTLPTSPSSNLTLAIVLLANESTVTMPPRNDQVRKDDISRPVGVTSTTGFGSGFTPSSTSNTLIGSSTRQISSPFNVTSTTGFESTSQPAGPPAPARELPISPSAQSNLTDISKSSRLADFYLDERNTSHQTSSLDPQASRWLPSSSERGSPRHERSAWSPDSSLAGSSPRLPLSQSDNTIDSVLGGATSGRTLPRSDSGLLITAPPKSTQTFQTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BI64</accession>
    <name>A0ABR3BI64_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610784.1">
        <property type="nucleotide sequence ID" value="XM_066760959.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993388"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="638" mass="69429" checksum="35C66C8F32AA4DD7" modified="2025-10-08" version="1">MPLFALLQSLLCRADTAPRIDPLPAGYSSMPVATNIPGPTFVPLQLPPDGHMDPGTFKDIIEAKQKTDLVLSHMRLVLAAQTQDGRRTTDTNDWNLIYNCIRDYSEQILTRWLNTYANHTAALRQLQQAGLYPSPCVALSAHMLGDQTMYASVGSRRSSQFIPPPLIRQSPLSVVVRDVTPANVIPAPGTSETQPDSAQPKQAIPPPLPEKTKSFPNPPQTSFQVPHKPLPPLKCEDSRPRPASWQAIPETTGAFFKALKRLSESEGLIPQEYAQLLERACRQEVPPVENQLATGDSVLASPVQSYTPEGSVFAIKTKEEHKTIRRIRPPSRDTVSRGPSDGNNADNHLHKISPTTSNTPISDSGKSTLRAAPTVATFSQDKANYQPLERLPTPPLKTDIISLASMSSALEPSGLPPFLQNEPFPIREPHSTPTEPTQRDSRNSLTTPSQSPARIVANLAREKSSLSTASEAVSLQPQGNELFLLYANVTPDFNLFAENGSINICPIYTRSSEEAKPEIHLEVPTPTSVTPGLTPLSETEPTSIPEPHPTPMDAEQMDLQNALTPPPKALSAASTPGGGYKTPDGSPVRAAISSVNKIVEKAKSSQEPISGHTEKDVQEDVKIRNVIQEVAEDPHQWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIK4</accession>
    <name>A0ABR3BIK4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spermatogenesis-associated protein 20-like TRX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I308_106286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610991.1">
        <property type="nucleotide sequence ID" value="XM_066760719.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993141"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="1">
        <location>
            <begin position="15"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAL0240492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="742" mass="83050" checksum="35AFB8E7155FD664" modified="2025-10-08" version="1">MSSTSATDTTPRLSNVLAKSKSPYLLQHKDNPVAWQEWSPETIALAQKLDKPIFLSSGYSACHWCHVLAHESFEDEETAKMMNEWFVNIKVDREERPDVDRMYMSYLQAVSGGGGWPMSVFMTPKLEPFFAGTYFPRPNFHQLLKKIHNIWEEDREKCEKMGKGVIEALKDMNDTGRTSESLSQLLSTSPASKLFAQLSTMNDPRYGGFTNAGSSTRGPKFPSCSITLEPLARLASIPGGGARNAEIREDAREMGMKMLRSMWSGGIRDWVGGGMARYSVDEKWMVPHFEKMLYDQAQLVSSCLDFARLYPADHPDRLLCYDLAADILKYTLRDLKSPEGGFWSAEDADSAEYKGAKKSEGAFYIWKKSEIDEVLGDDAPLFNSFFGVEPDGNVDIIHDSHGEMRDKNILHQHKTYEEVALEFGKKEDEAKDIIVQACEKLRLKREERERPGLDDKILTAWNGLMLTALSKASTLLPPSYDMCPQCLPAALGIVNFVKSHMWDSSTRTLTRSYREGKGPQAQTDDYAFLIQGLLNLYEATGDESHVLFAEELQKRQDELFWDDHDGGYFTSAEDPHVLVRMKDAQDGAEPSAAAVSAHNLSRFSLLLSSEFEDYEARAEATFLSMGPLIAQAPRAVGYAVSGLIDLEKGYREVIIVGSTKDDVVKKFLKEARETYFSNQIIIHIQPENLPKGLTEKNEVVKALVNDIESGKEKGASLRVCEGGTCGLPTKDFEGAKNLLKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIM7</accession>
    <name>A0ABR3BIM7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611044.1">
        <property type="nucleotide sequence ID" value="XM_066760772.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993194"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="526"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="659" mass="73174" checksum="DF5DF2FB884B48A9" modified="2025-10-08" version="1">MSVVPSKPETRQQAKTKAAGRDDPKDIFSQWRKGINPMGSKTPVANREVLATLRANVGSHNRQTNGNNGSKPLAQGPGAPESRSLFTADQAKTANILEKRPSTNAYTTSASKRARVNTEREATVGKTNKAEEERWTAKWIKVFPSLVFYFEIGAEEGSGKSLKSRVLKMGARVEQFFSTRVTHIIVKGGTTPQKPIKSVSQSRRAADAAKNPFLDGSKSTDLISKAEELQMKVWTVKKLSDILSRIAPIESLTNKDSLTTLLEDERVHGTRERDVTAPRPDYYYFKPGSKYLLIEDATGKHRTIMVKEYSSNQRDGSEWPTLFDSFLRISSSNQTMVPVNKIRDRAWKLYAEREPFEGEQPRELKRSASLHNLPSTPRLPDLPDAQPYQDASGNSVVITSNIASTSTPNTPIIAGGLPTLGCNKDRAIMQMSKRVQVLKGNARLAAAKRQSQNSSLPPAGTSAPNTIPERRRSMGQVELTKAFLPQEQVIRMLQQTREPIHDPTITVAERIRNREKVEMGLKGREQDTASGYCENCRLKYSDLSVHIASKKHRRFAENDANFASLDRLLISLQRPLHPSLLEPSLSPCDGPHTNDADCWRCNPMRGGDSGDEMADGMGDMDTDDILDKAVKLTCDVVRQEYVDGAGDSPQSQWGEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BIZ9</accession>
    <name>A0ABR3BIZ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I308_106532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IND107</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="4"/>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610783.1">
        <property type="nucleotide sequence ID" value="XM_066760958.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993387"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="6">
        <location>
            <begin position="190"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAL0240284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="431" mass="46846" checksum="400F2C73D5043BEA" modified="2025-10-08" version="1">MSNYKVADISLAAFGRKEIELAEHEMPGLMYLREKYAQSQPLKGARIAGCLHMTIQTAVLIETLTALGAQVTWSSCNIFSTQDHAAAAIAATGVPVFAWKGETEEEYLWCIDQTLKAFPGGQALNMILDDGGDLTSLVHEKYPELLNDVKGVSEETTTGVHHLYKMFKDGKLKVPAINVNDSVTKSKFDNYYGCRESLVDGIKRATDVMLAGKVAVVAGFGDVGKGCAESLRSYGARVIVTEIDPINALQAAMAGYEVTTMEEAAPRGNVFVTTTGCRDIITGAHFEAMPEDAIVSNIGHFDVEIDVAWLKANAAECVNIKPQVDRFTMKSGRHVILLAEGRLVNLGCGTGHPSFVMSCSFANQVLAQIALWTNPQAYPLGVHMLPKSLDEEVARAHLAQLGIKLTTMTKVQADYLGLPVQGPYKPDHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ11</accession>
    <name>A0ABR3BJ11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD binding dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I308_106704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IND107</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000014">
        <property type="protein sequence ID" value="KAL0240452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066610951.1">
        <property type="nucleotide sequence ID" value="XM_066761126.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993559"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08635">
        <property type="entry name" value="ox_reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="3">
        <location>
            <begin position="182"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAL0240452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45012" checksum="E7AAF2B619559FDF" modified="2025-10-08" version="1">MRAAPVDGLGHDDEVPSARLQPEPGPDVRVLVIGAGNINFGSDEGPWNHSQRLEQKLGNRLKIVGLVDPATSRAEAVLKAKSLTFAASAYADTPIYPSVKDAISALSSNPPEMILLGSPPAFRGTTDPSKGFNTEVQLTEGFPNAALFVEKPVSTGNVEEALKVAEYLEAKSNLVSVGYMLRYSAAVQKMKQILKENNLEVMMTSARYVMAYEHSAKVAWWTKSIDCGPIVEQATHFCDLSRYFAGEVDLDTVMAHSIEWYEKPGQLTKIPFNEDTLVPEDDRIPRFTSATWKYKSGAIGHLEHGVSLQGTEFSTEITVFADGYQLKLIDPYNRPTLYVRRPGSDVEEVHNFKDDDPFLSEMSTFIDMAGKSSSEIPVLSSFADAVRTYELTWAIRWASEKTRSSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ34</accession>
    <name>A0ABR3BJ34_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_106496</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IND107</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IND107</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611195.1">
        <property type="nucleotide sequence ID" value="XM_066760923.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993351"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="842"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1454"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="521"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="630"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1306"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="525"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1340"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1362"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1402"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1423"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0240696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="1627" mass="176111" checksum="3D6FC7803DEB7A5A" modified="2025-10-08" version="1">MSNHNGGKSPSQGASSTVSTCNKETLSTIDDVEHVMNGPPTTQEEWDRFITGYTLGNFTQQSFPPTTSIHSPSAHGGSIVGQDVKSQTSGPTASPNLPGQMPLTAPPNASSQTFKAQLLKKGAHTSLDDPSTLDDSSQEPSAIHFNTSSSGPSNQDPNIPNIPFTDKQEQSYFTSKAAEAKDKTKKFKHPEGMTRENMEKLGDEYKTETKRGKKGSSKGEKKAKVRPMKGDYRESSEEDAEKPSKRRARRPRSRGSWISRHEQSLDDPFLRAAQDAPLDPALLDSATNSSTSVSLADLNHNYAAERIRVREYFQKNGYLPPPRQTEEASRRRLRVIRRLGLENAETFQVETIDRLARLAVSFFKTNGAVISVIGKSKQLFLSEIGFGARSCEVDMSVCYHAMTMSQAGDKCIVINDASKDWRFRKNPLVDEGRGPVQFYAGAPLKVGQGSREVIIGTLCVVDNKPRDDFEMDQRELLADLARCVVSELELLYSQHAAIESAKLHQISVDFLRRSLKHRPLERAGRSTGISSGSGSTPMGGDRAGNDGSSASGSTRSSGSHKRIEGADEHQNDETVDIYDEACREIRSALDAYAVAVVDLSQFHLFYPAYQNSSTGGGSTRAGSVMETATGSGATTVRPGASSSIDQTTSTTSTVEEEDNLWDSKKKQARPTYSKNDPLAPVRTPQVLFIPSRPRTKPKWYNQNTEQKPSELDTLAVLGYSCAHDNYAFNFTTSPAARKIVADFIAGNVTARKVWYTRDDSEGIAASITHLMPPGTETSLALPVFGFDGQVSFAVVACWKDPLYTYPAGAIQFVETIAGSLLASVLKERLLQAERAQLKFASAASHELRTPLHQIHAAASTLRTSLQPVLQSSDAPDVPPSRLSADDRQEVLAQLDLIDSNSLSLAGILENVINTLDMGRMAESEGYANDHTPDIVTPQDTSRAVSLSAVLEKVVDDAMELESKTRRAVGGKGLEDVEVILEVLPRQRGGWLTVKDIAPLARATEKIIHNAIKFTDKGHVHITVQDVSREVILPAGYDNSVKVSTISIDIKDTGRGMSADFLDREILQPFSKEDPFVSGSGLGLTLSQRIIELIGGKIAIASSPGKGTLVHIEVPLQLLNDDSNSDQDDLGRNDGAPDAIGESNAIRTDGIYLIGFATSKNSALRRVGKSLARQLKLHKCRVVTEINYASLIVTLEGGVTDTELARLCRSARPDVQVIVLESDRIKYGSTYVSSPLHAHTNPVRSHSDPTATLRTPEDQEYLDRIPIIHLTRPLRPSVVRRIMDPASEVPREPERYVSDVVGGDEAKEEAAAAARASIQHVQKPPSASVSRSEGAEHAVKPSSTAPTDPTFTTSTAPPATLEEASSSDIGSGSETQNEDLPSASSTSVSGSDMRSGTEVLSGMSVSASGTSGVSESAVYGGSESSDHSTTEMDGKNERKSDKTSKPPTKGLTVLKVLVVEDNVINRKILTTMLRRASCNFAEAIDGVDAVDQFSIFQPDLVLLDITMPRKDGFAAAAEMRQLETVRHVAEDVPNPPSPIAAELIESALGSLDINAPGSSSASSSAGSSYSIKLKKRARIIAVTAMSAEHQKRKGLYECGIDYWMTKPLSMSVLRSMVEKMKEEINEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJ40</accession>
    <name>A0ABR3BJ40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I308_106503</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611202.1">
        <property type="nucleotide sequence ID" value="XM_066760930.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993358"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="344"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="674"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAL0240703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="883" mass="97831" checksum="32B4D9B5660734E4" modified="2025-10-08" version="1">MIHTLLDYLMKSILEETSFLPQYLPNDSDKGVQLWLVQGSFTENISSASPTAGSQEHDNSASTSIHQSRLLARDSISLPQRSNSNDQPPAQAAPHHSPLRASAPAPHSAASHLPQRRVEQPTATRDHSSSAMDGQHDKEEDGDFAAGVALLSLNSASEPHFLGASSGSTWAKLVSSVWRRPGISLYHTNPIRSGQSHGTPSDVSENQLQPHQCLLPSPGDSEILFKACYMHVQARYAFPDWIELRRWISQQESLLRASVENDVNTPEGKVSRVAMFFILMVYSVGSRLMQATPVKVSTAAAPEAYYASALCYMEVIMMLHDIHHVQALLWLIMYSIRCSEGPSAWHLIGMAMRMALELGMHRRRKRPFDVTPYHEEVRKRTWWALYGIDRWFSLTLGRPFGIDDRDTDQFLPADINCDVQITETPPSAPFVSESPPGPSQVTSMSSAIHMFRLRRIESQIQRYVYAVQKDDISDMGLTSPSSTASVSKWQPVHESLLEQVERWKKMIPKQNNGLGSQPLPCCEEDYFQMKAETTKLLILRPFSASAKSGDRVLSLCGHAAASLCEMYRRVHRRYPATHSLCLADLHGIFLTGLTLLSVLSIDRKALPASIAHRALRACSTSLFIYAQHYPVAEPFRDAFEDLATACSDDSNEPPDPITYQSAIRFANDGPYASRGDRSAPIDLHPTFGGIVSSDGPTSDSSRDRNSHIFNLSTTDQATRMSIDDSSLDCGEAASHLGMSIAASARTQRPSNPQNQSTNHMTFDEHNICPEMRNLPDGRPTREETFALLPNETLYPNPCQQGASVDAGNDSDQLLDGILAASHFPVPPIDRTRPGPESGYQPTVNQVLDQLLSANFYDGFAADNCAEESFSSEIPFDYLSWTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJE8</accession>
    <name>A0ABR3BJE8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_106400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IND107</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611101.1">
        <property type="nucleotide sequence ID" value="XM_066760829.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993255"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF143">
        <property type="entry name" value="CSC1_OSCA1-LIKE 7TM REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="15"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="403"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="768"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="732"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0240602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="839" mass="92433" checksum="E61121E3182608ED" modified="2025-10-08" version="1">MSATNADVQSSTTGSFVAALVVAGITVGGFSTLWLVLHGRKDLQRVFQPRTILPPEGKRPQPLPSGIIAFWKTLFKTPDQDIIVSNGPDAYFYVRFLKVFGLQMLIPYVILTCAILIPVSAVSPNQGMQGLNILTFGNVASSDQVRHVAHFLVTIILMSWTVFLIWREYNHFVDVRQTWMTTPQHLSLARARTIAITNIPESINSSTGIKELAGLVSRIGAGNGSGTNLLALTNPFSRQSIATENTGANGDSEGGVRHVWLTRKCKDIEKVWEERDAECARLEGGVAKLQKRAAKNVRKGKTPMQQGRFDPESSGGDLIDGYVLPKKRPSWKQGLLGLIGTEDLPQGNTAFIRFSSQFEAHAFAKLASKTDKSNMFIRGGVELVPEDIEWSNISMSPYERQIRTIVSWCLTVGLIIVWAIPVAFVGMVSNIDTLCANASWLAWVCRLPSPALAIIKGVLPPALLAVLFMLLPVVLRLMVKMQGEIRKSDIELRLFSRFWLFQVIHGFLIVTLASGLMNALGNLGNTASQVPTLLADKLPGASIFFLTFILTATFSGAAKTYSRLVPWIMYLLRNILAGGTPRKAYMKKYKMDSFAWATAFPPTCLIMCVTIVYSVIQPIITALAWVAFILLYFANKYVIHWCADQPDAGETGGQFYIKALRTIFVSLYIQGVCMAGLFFLSTNENGSRSKTGLGCGAVMCVMIICIAFIQIYIDWFRFTKPYLIYVHRTPSVPNSSSVEPKVGRGGVTDSPSDEDALAGPELGNTSGFHERAFDHPALWKKQPVIWVAVDPHGLGALEVERINDKGVEASLEYAVMNEKGQIDVQRSPPDEAWYEGFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BJS5</accession>
    <name>A0ABR3BJS5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_106315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000013">
        <property type="protein sequence ID" value="KAL0240521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611020.1">
        <property type="nucleotide sequence ID" value="XM_066760748.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91993170"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="445"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="600"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0240521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="759" mass="84786" checksum="8B04C23724FB853F" modified="2025-10-08" version="1">MSAVPEQPAVEALNDKLQSIQLDTSRRAANDRYLNRPYVQLQYPTAQRQPQPQPQPQPQPQPQAQAYQPYAQAYTPYPQHYHQSPYTTYLTYSPYPNQLAWRPLPGSEQTSPIDPTNQHQHQHQHYGLWGSPPMSPVNAPQFLPGPSSTAMFDDFGVGGGVSGAGTAYYGPRPPYGSPPSVWQSPTAPPPSSFFYVPFQQHASVMGPALQLSDWSTFNNNVNLPGPSKPSPVSPTDSKVPERKSYHPQPPSKRSDWVMWVGNVPNNTTHEELWHFFNVTVPITNTQSDAEPWRGPSSIFLISRSSCAFVNLSSQTDLERAVSFFNGKPLRPWDPRCPRMVCRVRRKDDDLKSGVGAQRGTGMHRQWVKKDKDKDKEKEREMEESKTGQMSAVTVSSGPPSPTISAPAPDGPGRRRDSIVGEEKRKFSSGSYASTNSSFLMRHFPRRIFILKSLTTAELEESVKTGMWRTQQHNEPILDQAFRTSQSVFLIFGANRAGEFFGYARMVEPIDKEQAKHRQFSTSTVPRRSTTADSDRFFVPPYLSRVTTMSPGELATPREDSYFPVSTAHRKTDPPKIPNHAAPSSSLAAGEPRAHTFDSKALQRDYHYPSVTLAPAEAETGVPSSDKGSKPVSPELEPSQESSQLMDDQGVLRKDTLPIASSSEQQVDRLHQGEQETLKELSNEGWGHSFCIEWIKHTPLPFSRTRHLRNPWNADREVKVSRDGTEVEPSVGLALMAEWDKIDTVPGLSPDRAQATTLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK50</accession>
    <name>A0ABR3BK50_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus gattii MMRL2647.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IND107</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IND107</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611552.1">
        <property type="nucleotide sequence ID" value="XM_066760248.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992654"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045674113" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="16"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <sequence length="368" mass="38749" checksum="E2033EB63E5B75AD" modified="2025-10-08" version="1">MISSTAATVLGLVLTSVGVQASTPLVRTYQGDSFFDRWSYYGHYDNTTNGDAIFANKSVATSTPELTYVTSDGSAIIRVDNSSTVQYNYKRDTVKITSTDSYPVGSIWVLDAVHLPYGCSVWPAFWSYGAGATWPEDGEIDVIEGVNMGFSNQMALHTEDGCSIGSSGSSFSGIVNDTSCYYEDNDNSGCGVTDTNDASYGAAFAAAGGGVFVTELAESGISIWFFSRSDIPDSISNADNEIDTSNLGTPSAYWGADTCDITKLFGDQSLVFDITLCGDWAGQSSILASTGCSALSGSDTCYTTYVLNASNYDTAYFEINSLKVYSNGSSSSSSSDSSSSSAPSTHSFSALGWLFASVMGVSALIGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BK61</accession>
    <name>A0ABR3BK61_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Programmed cell death protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I308_105805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IND107</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611558.1">
        <property type="nucleotide sequence ID" value="XM_066760254.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992660"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAL0242176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054399"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15635" checksum="1339B01989F78936" modified="2025-10-08" version="1">MSGINLPPGLRPSSGPPQQGGQRGGPSPEEREAAEARARQQDEMKRTMIAAMLEPAARERLSRISLTRPQLAAQVETLLFNMGQQGQIRGQVSDEALKGLLEQVSNPAPAKSTSSVPQSSRTKILGGGITIQRKRDDSDSDEYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABR3BKC8</accession>
    <name>A0ABR3BKC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I308_105864</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus tetragattii IND107</name>
        <dbReference type="NCBI Taxonomy" id="1296105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
            <taxon>Cryptococcus gattii species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="Murphy C."/>
                <person name="Naylor J."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-01" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="Mcginley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IND107</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ATAM02000011">
        <property type="protein sequence ID" value="KAL0242235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_066611617.1">
        <property type="nucleotide sequence ID" value="XM_066760313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="91992719"/>
    <dbReference type="Proteomes" id="UP000054399">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="875"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="610"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="848"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="855"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAL0242235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
  
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